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1. Correction: Spanò et al. Effect of Dual-Task Motor-Cognitive Training in Preventing Falls in Vulnerable Elderly Cerebrovascular Patients: A Pilot Study. Brain Sci. 2022, 12, 168

Author

Spanò, Barbara, primary, Lombardi, Maria G., additional, De Tollis, Massimo, additional, Szczepanska, Maria A., additional, Ricci, Claudia, additional, Manzo, Alice, additional, Giuli, Simone, additional, Polidori, Lorenzo, additional, Griffini, Ivo A., additional, Adriano, Fulvia, additional, Caltagirone, Carlo, additional, and Annicchiarico, Roberta, additional

Published
2024
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12. The Effect of Dual-Task Motor-Cognitive Training in Adults with Neurological Diseases Who Are at Risk of Falling

Author

Spanò, Barbara, primary, De Tollis, Massimo, additional, Taglieri, Sara, additional, Manzo, Alice, additional, Ricci, Claudia, additional, Lombardi, Maria G., additional, Polidori, Lorenzo, additional, Griffini, Ivo A., additional, Aloisi, Marta, additional, Vinicola, Vincenzo, additional, Formisano, Rita, additional, Caltagirone, Carlo, additional, and Annicchiarico, Roberta, additional

Published
2022
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16. Effect of Dual-Task Motor-Cognitive Training in Preventing Falls in Vulnerable Elderly Cerebrovascular Patients: A Pilot Study

Author

Spanò, Barbara, primary, Lombardi, Maria G., additional, De Tollis, Massimo, additional, Szczepanska, Maria A., additional, Ricci, Claudia, additional, Manzo, Alice, additional, Giuli, Simone, additional, Polidori, Lorenzo, additional, Griffini, Ivo A., additional, Adriano, Fulvia, additional, Caltagirone, Carlo, additional, and Annicchiarico, Roberta, additional

Published
2022
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18. Relapsing–remitting and secondary‐progressive multiple sclerosis patients differ in decoding others' emotions by their eyes

Author

Argento, Ornella, primary, Spanò, Barbara, additional, Serra, Laura, additional, Incerti, Chiara Concetta, additional, Bozzali, Marco, additional, Caltagirone, Carlo, additional, Francia, Ada, additional, Fratino, Mariangela, additional, Nocentini, Ugo, additional, Piacentini, Chiara, additional, Quartuccio, Maria Esmeralda, additional, and Pisani, Valerio, additional

Published
2021
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21. Left egocentric neglect in early subacute right-stroke patients is related to damage of the superior longitudinal fasciculus

Author

Spanò, Barbara, primary, Nardo, Davide, additional, Giulietti, Giovanni, additional, Matano, Alessandro, additional, Salsano, Ilenia, additional, Briani, Chiara, additional, Vadalà, Rita, additional, Marzi, Claudia, additional, De Luca, Maria, additional, Caltagirone, Carlo, additional, and Santangelo, Valerio, additional

Published
2021
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25. Evidence for interhemispheric imbalance in stroke patients as revealed by combining transcranial magnetic stimulation and electroencephalography

Author

Casula, Elias Paolo, primary, Pellicciari, Maria Concetta, additional, Bonnì, Sonia, additional, Spanò, Barbara, additional, Ponzo, Viviana, additional, Salsano, Ilenia, additional, Giulietti, Giovanni, additional, Martino Cinnera, Alex, additional, Maiella, Michele, additional, Borghi, Ilaria, additional, Rocchi, Lorenzo, additional, Bozzali, Marco, additional, Sallustio, Fabrizio, additional, Caltagirone, Carlo, additional, and Koch, Giacomo, additional

Published
2021
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29. Relapsing–remitting and secondary‐progressive multiple sclerosis patients differ in decoding others' emotions by their eyes.

Author

Argento, Ornella, Spanò, Barbara, Serra, Laura, Incerti, Chiara Concetta, Bozzali, Marco, Caltagirone, Carlo, Francia, Ada, Fratino, Mariangela, Nocentini, Ugo, Piacentini, Chiara, Quartuccio, Maria Esmeralda, and Pisani, Valerio

Subjects
*MULTIPLE sclerosis, *EMOTION recognition, *MAGNETIC resonance imaging, *SOCIAL adjustment, *DISEASE relapse, *EMOTIONAL state
Abstract

Background and purpose: Difficulties in emotion processing and social cognition identified in multiple sclerosis (MS) patients have a potential impact on their adaptation to the social environment. We aimed to explore the neural correlates of emotion recognition in MS and possible differences between relapsing–remitting MS (RRMS) and secondary progressive MS (SPMS) patients by the Reading the Mind in the Eyes test (RMEt). Methods: A total of 43 MS patients (27 RRMS, 16 SPMS) and 25 matched healthy controls (HC) underwent clinical assessments, RMEt, and a high‐resolution T1‐weighted 3‐T magnetic resonance imaging (MRI) scan. The number of correct answers on the RMEt was compared between groups. T1‐weighted volumes were processed according to an optimized voxel‐based morphometry (VBM) protocol to obtain gray matter (GM) maps. Voxelwise analyses were run to assess potential associations between RMEt performance and regional GM volumes. Results: Taken altogether, MS patients reported significantly lower performance on the RMEt compared to HC. When dividing the patients into those with RRMS and those with SPMS, only the latter group was found to perform significantly worse than HC on the RMEt. VBM analysis revealed significant association between RMEt scores and GM volumes in several cortical (temporoparieto‐occipital cortex) and subcortical (hippocampus, parahippocampus, and basal ganglia) brain regions, and in the cerebellum in SPMS patients only. Conclusions: Results suggest that, in addition to other clinical differences between RRMS and SPMS, the ability to recognize others' emotional states may be affected in SPMS more significantly than RRMS patients. This is supported by both behavioral and MRI data. [ABSTRACT FROM AUTHOR]

Published
2022
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31. Dual-Task Performance in Multiple Sclerosis' Patients: Cerebellum Matters?

Author

Argento, Ornella, Spanò, Barbara, Pisani, Valerio, Incerti, Chiara C, Bozzali, Marco, Foti, Calogero, Caltagirone, Carlo, and Nocentini, Ugo

Subjects
*MULTIPLE sclerosis, *CEREBELLUM, *COGNITIVE ability, *COGNITION disorders, *WALKING
Abstract

Objective Gait, cognitive impairments, and their mutual influence in dual tasking (cognitive–motor dual tasking, CM-DT) are important to address therapeutic approaches in patients with multiple sclerosis (PMS). CM-DT correlates have been widely investigated with variable and dissimilar results, due to differences in methods. However, although the cerebellum has recently shown to be involved in both motor and cognitive functions, few studies have explored its role in the integration of the concurrent execution of gait and cognition. This case–control study aims to explore the effects of adding a cognitive task to walking in PMS and to investigate the role of the cerebellum in the interfering process. Methods In total, 20 patients and 18 healthy controls (HC) underwent clinical assessments, dual task (DT), and 3 T magnetic resonance imaging (MRI). DT was composed by three 2-min trials requiring fast walking. In 2 of them 2 different cognitive tasks were added. Results Both groups evidenced the presence of cognitive–motor interference (CMI) for both cognitive conditions with a greater effect of word list generation task in PMS. Analysis of variance between HC and patients with high or low performances showed a significantly increased volume in Vermis lobules VIIIa and IX of high performers compared with HC. Conclusion Our results show that CMI is also present in healthy individuals but is significantly more disabling in PMS. Furthermore, MRI data point to the existence of an initial mechanism of cerebellar reorganization in PMS with lower interference. Subsequently, the failure of this mechanism due to the progression of disability leads to a more evident expression of symptoms. [ABSTRACT FROM AUTHOR]

Published
2021
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32. Whole brain white matter histogram analysis of diffusion tensor imaging data detects microstructural damage in mild cognitive impairment and alzheimer's disease patients

Author

Giulietti, Giovanni, Torso, Mario, Serra, Laura, Spanò, Barbara, Marra, Camillo, Caltagirone, Carlo, Cercignani, Mara, and Bozzali, Marco

Subjects
Settore MED/26 - NEUROLOGIA, R895, alzheimer's disease, cognitive dysfunction, diffusion tensor imaging, magnetic resonance imaging, white matter, Alzheimer's disease
Abstract

\ud Background: \ud Amnestic mild cognitive impairment (MCI) is a transitional stage between normal aging and Alzheimer’s disease (AD). However, the clinical conversion from MCI to AD is unpredictable. Hence, identification of non-invasive biomarkers able to detect early changes induced by dementia is a pressing need.\ud \ud Purpose: \ud To explore the added value of histogram analysis applied to measures derived from diffusion tensor imaging (DTI) for detecting brain tissue differences between AD, MCI and healthy subjects (HS).\ud \ud Study type: \ud Retrospective.\ud \ud Population/subjects: \ud Local cohort (57 AD, 28 MCI, 23 HS), Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort (41 AD, 58 MCI, 41 HS).\ud \ud Field Strength: \ud 3T. Dual echo TSE; FLAIR; MDEFT; IR-SPGR; DTI.\ud \ud Assessment: \ud Normal appearing white matter (NAWM) masks were obtained using the T1-weighted volumes for tissue segmentation and T2-weighted images for removal of hyperintensities/lesions. From DTI images, fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AXD) and radial diffusivity (RD) were obtained. NAWM histograms of FA, MD, AXD and RD were derived and characterized estimating: peak height, peak location, mean value (MV), and quartiles (C25, C50, C75), which were compared between groups. Receiver operating characteristic (ROC) and area under ROC curves (AUC) were\ud calculated. To confirm our results, the same analysis was repeated on ADNI dataset.\ud \ud Statistical tests: \ud One-way ANOVA, post-hoc Student’s t-test, multi-class ROC analysis.\ud \ud Results: \ud For the local cohort, C25 of AXD had the maximum capability of group discrimination with AUC of 0.80 for “HS vs patients” comparison and 0.74 for “AD vs others” comparison. For ADNI cohort, MV of AXD revealed the maximum group discrimination capability with AUC of 0.75 for “HS vs patients” comparison and 0.75 for “AD vs others” comparison.\ud \ud Data conclusion: \ud AXD of NAWM might be an early marker of microstructural brain tissue changes occurring during AD course and might be useful for assessing disease progression.

Published
2018

36. Brain Connectivity Changes in Autosomal Recessive Parkinson Disease: A Model for the Sporadic Form

Author

Makovac, Elena, primary, Cercignani, Mara, additional, Serra, Laura, additional, Torso, Mario, additional, Spanò, Barbara, additional, Petrucci, Simona, additional, Ricciardi, Lucia, additional, Ginevrino, Monia, additional, Caltagirone, Carlo, additional, Bentivoglio, Anna Rita, additional, Valente, Enza Maria, additional, and Bozzali, Marco, additional

Published
2016
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37. CSF β-amyloid as a putative biomarker of disease progression in multiple sclerosis

Author

Pietroboni, Anna M, primary, Schiano di Cola, Francesca, additional, Scarioni, Marta, additional, Fenoglio, Chiara, additional, Spanò, Barbara, additional, Arighi, Andrea, additional, Cioffi, Sara MG, additional, Oldoni, Emanuela, additional, De Riz, Milena A, additional, Basilico, Paola, additional, Calvi, Alberto, additional, Fumagalli, Giorgio G, additional, Triulzi, Fabio, additional, Galimberti, Daniela, additional, Bozzali, Marco, additional, and Scarpini, Elio, additional

Published
2016
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38. “I Know that You Know that I Know”: Neural Substrates Associated with Social Cognition Deficits in DM1 Patients

Author

Serra, Laura, primary, Cercignani, Mara, additional, Bruschini, Michela, additional, Cipolotti, Lisa, additional, Mancini, Matteo, additional, Silvestri, Gabriella, additional, Petrucci, Antonio, additional, Bucci, Elisabetta, additional, Antonini, Giovanni, additional, Licchelli, Loretta, additional, Spanò, Barbara, additional, Giacanelli, Manlio, additional, Caltagirone, Carlo, additional, Meola, Giovanni, additional, and Bozzali, Marco, additional

Published
2016
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41. Brain Connectomics’ Modification to Clarify Motor and Nonmotor Features of Myotonic Dystrophy Type 1

Author

Serra, Laura, primary, Mancini, Matteo, additional, Silvestri, Gabriella, additional, Petrucci, Antonio, additional, Masciullo, Marcella, additional, Spanò, Barbara, additional, Torso, Mario, additional, Mastropasqua, Chiara, additional, Giacanelli, Manlio, additional, Caltagirone, Carlo, additional, Cercignani, Mara, additional, Meola, Giovanni, additional, and Bozzali, Marco, additional

Published
2016
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46. CSF β-amyloid as a putative biomarker of disease progression in multiple sclerosis.

Author

Pietroboni, Anna M., Schiano di Cola, Francesca, Scarioni, Marta, Fenoglio, Chiara, Spanò, Barbara, Arighi, Andrea, Cioffi, Sara M. G., Oldoni, Emanuela, De Riz, Milena A., Basilico, Paola, Calvi, Alberto, Fumagalli, Giorgio G., Triulzi, Fabio, Galimberti, Daniela, Bozzali, Marco, and Scarpini, Elio

Subjects
MULTIPLE sclerosis, CEREBROSPINAL fluid, BIOMARKERS, NEURODEGENERATION, DISEASE progression, PATIENTS, DIAGNOSIS, PHYSIOLOGY
Abstract

Background: Neurodegeneration plays a major role in determining disability in multiple sclerosis (MS) patients. Hence, there is increasing need to identify reliable biomarkers, which could serve as prognostic measure of disease progression. Objectives: To assess whether cerebrospinal fluid (CSF) tau and β-amyloid (Aβ) levels were altered in newly diagnosed MS patients and correlated with disability. Moreover, we investigated whether these CSF biomarkers associate with macroscopic brain tissue damage measures. Methods: CSF Aβ and tau levels were determined by enzyme-linked immunosorbent assay in CSF samples from 48 newly diagnosed MS patients, followed-up clinically for 3 years by recording their Expanded Disability Status Scale score at 6-month intervals, and 45 controls. All patients underwent magnetic resonance imaging at baseline and at the end of follow-up to quantify their lesion load (LL). Results: CSF Aβ levels were significantly reduced in patients compared to controls (p < 0.001). Lower CSF Aβ levels at baseline were a disability predictor at 3-year follow-up (p = 0.009). CSF tau levels correlated with T2- and T1-LL (p < 0.001). Conclusion: CSF Aβ reduction is a promising biomarker of neurodegeneration and may predict patients’ clinical outcome. Therefore, CSF Aβ should be considered as a potential biomarker of prognostic value. [ABSTRACT FROM AUTHOR]

Published
2017
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47. Network-Based Substrate of Cognitive Reserve in Alzheimer's Disease.

Author

Serra, Laura, Mancini, Matteo, Cercignani, Mara, Di Domenico, Carlotta, Giulietti, Giovanni, Koch, Giacomo, Marra, Camillo, Bozzali, Marco, Spano, Barbara, and Spanò, Barbara

Subjects
ALZHEIMER'S disease, COGNITION disorders, NEUROBIOLOGY, MILD cognitive impairment, NEUROPSYCHIATRY, PSYCHOLOGICAL aspects of aging, AGING, BRAIN, BRAIN mapping, COGNITION, LONGITUDINAL method, MAGNETIC resonance imaging, NEUROPSYCHOLOGICAL tests, RELAXATION for health, ATROPHY, NEURAL pathways
Abstract

Cognitive reserve (CR) is known to modulate the clinical features of Alzheimer's disease (AD). This concept may be critical for the development of non-pharmacological interventions able to slow down patients' cognitive decline in the absence of disease-modifying treatments. We aimed at identifying the neurobiological substrates of CR (i.e., neural reserve) over the transition between normal aging and AD, by assessing the underlying brain networks and their topological properties. A cohort of 154 participants (n = 68 with AD, n = 61 with amnestic mild cognitive impairment (aMCI), and 25 healthy subjects) underwent resting-state functional MRI and neuropsychological testing. Within each group, participants were classified as having high or low CR, and functional connectivity measures were compared, within group, between high and low CR individuals. Network-based statistics and topological network properties derived from graph theory were explored. Connectivity differences between high and low CR were evident only for aMCI patients, with participants with high CR showing a significant increase of connectivity in a network involving mainly fronto-parietal nodes. Conversely, they showed significantly decreased connectivity in a network involving fronto-temporo-cerebellar nodes. Consistently, changes to topological measures were observed in either direction, and were associated with measures of global cognitive function. These findings support the hypothesis that CR impacts on neurodegenerative process in the early phase of AD only. In addition, they fit with the existence of a "neural reserve", characterized by specific neural networks and their efficiency. It remains to be demonstrated whether interventions later in life can modulate this "neural reserve". [ABSTRACT FROM AUTHOR]

Published
2017
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50. Mild Cognitive Impairment: Same Identity for Different Entities

Author

Serra, Laura, primary, Giulietti, Giovanni, additional, Cercignani, Mara, additional, Spanò, Barbara, additional, Torso, Mario, additional, Castelli, Diana, additional, Perri, Roberta, additional, Fadda, Lucia, additional, Marra, Camillo, additional, Caltagirone, Carlo, additional, and Bozzali, Marco, additional

Published
2013
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