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1. Infants Requiring Maintenance Dialysis: Outcomes of Hemodialysis and Peritoneal Dialysis

Author

Shtiza, D., Kramar, R., Oberbauer, R., Baiko, S., Sukalo, A., van Hoeck, K., Collart, F., des Grottes, J.M., Pokrajac, D., Roussinov, D., Batinić, D., Lemac, M., Slavicek, J., Seeman, T., Vondrak, K., Heaf, J.G., Toots, U., Finne, P., Grönhagen-Riska, C., Couchoud, C., Lasalle, M., Sahpazova, E., Abazi, N., Ristoka Bojkovska, N., von Gersdorff, G., Scholz, C., Tönshoff, B., Krupka, K., Höcker, B., Pape, L., Afentakis, N., Kapogiannis, A., Printza, N., Reusz, G., Berecki, C.S., Szabó, A., Szabó, T., Györke, Z.S., Kis, E., Palsson, R., Edvardsson, V., Gianoglio, B., Maringhini, S., Pecoraro, C., Picca, S., Testa, S., Rudaitis, S., Said-Conti, V., Gatcan, S., Berbeca, O., Zaikova, N., Pavićević, S., Leivestad, T., Zagozdzon, I., Mota, C., Almeida, M., Afonso, C., Mircescu, G., Garneata, L., Molchanova, E.A., Tomilina, N.A., Bikbov, B.T., Kostic, M., Peco-Antic, A., Spasojevic-Dimitrijeva, B., Milosevski-Lomic, G., Paripovic, D., Puric, S., Kruscic, D., Podracka, L., Kolvek, G., Buturovic-Ponikvar, J., Novljan, G., Battelino, N., Alonso Melgar, A., Schön, S., Prütz, K.G., Backmän, L., Stendahl, M., Evans, M., Rippe, B., Kuenhi, C.E., Maurer, E., Laube, G.F., Tschumi, S., Parvex, P., Hoitsma, A., Hemke, A., Topaloglu, R., Ivanov, D., Pruthi, R., Braddon, F., Mannings, S., Cassula, A., Sinha, M.D., Vidal, Enrico, van Stralen, Karlijn J., Chesnaye, Nicholas C., Bonthuis, Marjolein, Holmberg, Christer, Zurowska, Aleksandra, Trivelli, Antonella, Da Silva, José Eduardo Esteves, Herthelius, Maria, Adams, Brigitte, Bjerre, Anna, Jankauskiene, Augustina, Miteva, Polina, Emirova, Khadizha, Bayazit, Aysun K., Mache, Christoph J., Sánchez-Moreno, Ana, Harambat, Jérôme, Groothoff, Jaap W., Jager, Kitty J., Schaefer, Franz, and Verrina, Enrico

Published
2017
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2. Kidney Versus Combined Kidney and Liver Transplantation in Young People With Autosomal Recessive Polycystic Kidney Disease: Data From the European Society for Pediatric Nephrology/European Renal Association−European Dialysis and Transplant (ESPN/ERA-EDTA) Registry

Author

Levtchenko, E., Haffner, D., Bjerre, A., Massy, Z., Shtiza, D., Kramar, R., Oberbauer, R., Baiko, S., Sukalo, A., van Hoeck, K., Collart, F., des Grottes, J.M., Pokrajac, D., Roussinov, D., Batinić, D., Lemac, M., Slavicek, J., Seeman, T., Vondrak, K., Heaf, J.G., Toots, U., Finne, P., Grönhagen-Riska, C., Couchoud, C., Lasalle, M, Sahpazova, E, Abazi, N, Ristoka Bojkovska, N, von Gersdorff, G, Scholz, C, Tönshoff, B, Krupka, K, Höcker, B, Pape, L, Afentakis, N, Kapogiannis, A, Printza, N, Reusz, G, Berecki, Cs, Szabó, A, Szabó, T, Györke, Z.S., Kis, E., Palsson, R., Edvardsson, V., Gianoglio, B., Maringhini, S., Pecoraro, C., Picca, S., Testa, S., Vidal, E., Verrina, E., Jankauskiene, A., Pundziene, B., Said-Conti, V., Gatcan, S., Berbeca, O., Zaikova, N., Pavićević, S., Leivestad, T., Zurowska, A., Zagozdzon, I., Mota, C., Almeida, M., Afonso, C., Mircescu, G., Garneata, L., Molchanova, E.A., Tomilina, N.A., Bikbov, B.T., Kostic, M., Peco-Antic, A., Spasojevic-Dimitrijeva, B., Milosevski-Lomic, G., Paripovic, D., Puric, S., Kruscic, D., Podracka, L., Kolvek, G., Buturovic-Ponikvar, J., Novljan, G., Battelino, N., Alonso Melgar, A., Schön, S., Prütz, K.G., Backmän, L., Stendahl, M., Evans, M., Rippe, B., Kuenhi, C.E., Maurer, E., Laube, G.F., Tschumi, S., Parvex, P., Hoitsma, A., Hemke, A., Topaloglu, R., Duzova, A., Ivanov, D., Pruthi, R., Braddon, F., Mannings, S., Cassula, A., Sinha, M.D., Mekahli, Djalila, van Stralen, Karlijn J., Bonthuis, Marjolein, Jager, Kitty J., Balat, Ayşe, Benetti, Elisa, Godefroid, Nathalie, Edvardsson, Vidar O., Heaf, James G., Jankauskiene, Augustina, Kerecuk, Larissa, Marinova, Svetlana, Puteo, Flora, Seeman, Tomas, Zurowska, Aleksandra, Pirenne, Jacques, Schaefer, Franz, and Groothoff, Jaap W.

Published
2016
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3. Identification of subgroups by risk of graft failure after paediatric renal transplantation: application of survival tree models on the ESPN/ERA-EDTA Registry

Author

Lofaro, Danilo, Jager, Kitty J., Abu-Hanna, Ameen, Groothoff, Jaap W., Arikoski, Pekka, Hoecker, Britta, Roussey-Kesler, Gwenaelle, Spasojević, Brankica, Verrina, Enrico, Schaefer, Franz, van Stralen, Karlijn J., Coppo, R., Haffner, D., Harambat, J., Stefanidis, C., Shitza, D., Kramar, R., Oberbauer, R., Baiko, S., Sukalo, A., van Hoeck, K., Collart, F., des Grottes, J.M., Pokrajac, D., Resić, H., Prnjavorac, B., Roussinov, D., Batinić, D., Lemac, M., Slavicek, J., Seeman, T., Vondrak, K., Heaf, J.G., Toots, U., Finne, P., Grönhagen-Riska, C., Couchoud, C., Lasalle, M., Sahpazova, E., Gersdorf, G., Barth, C., Scholz, C., Tönshoff, B., Ioannidis, G., Kapogiannis, A., Papachristou, F., Reusz, G., Túri, S., Szabó, L., Szabó, T., Reusz, G., Györke, Zs., Kis, E., Palsson, R., Edvardsson, V., Mencarelli, F., Paglialonga, F., Pecoraro, C., Picca, S., Roperto, R., Vidal, E., Verrina, E., Jankauskiene, A., Pundziene, B., Said-Conti, V., Gatcan, S., Berbeca, O., Zaikova, N., Pavićević, S., Leivestad, T., Bjerre, A., Zurowska, A., Zagozdzon, I., Mota, C., Almeida, M., Afonso, C., Mircescu, G., Garneata, L., Podgoreanu, E., Molchanova, E.A., Tomilina, N.A., Bikbov, B.T., Kostic, M., Peco-Antic, A., Puric, S., Kruscic, D., Spasojevic-Dimitrijeva, B., Milosecski-Lomic, G., Paripovic, D., Podracka, L., Kolvek, G., Buturovic-Ponikvar, J., Novljan, G., Battelino, N., Alonso Melgar, A., Schön, S., Prütz, K.G., Seeberger, A., Backmän, L., Evans, M., Kuenhi, C.E., Maurer, E., Laube, G., Simometi, G., Hoitsma, A., Hemke, A., Topaloglu, R., Duzova, A., Ivanov, D., and Sinha, M.

Published
2016
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4. Infants Requiring Maintenance Dialysis: Outcomes of Hemodialysis and Peritoneal Dialysis

Author

Vidal, Enrico, primary, van Stralen, Karlijn J., additional, Chesnaye, Nicholas C., additional, Bonthuis, Marjolein, additional, Holmberg, Christer, additional, Zurowska, Aleksandra, additional, Trivelli, Antonella, additional, Da Silva, José Eduardo Esteves, additional, Herthelius, Maria, additional, Adams, Brigitte, additional, Bjerre, Anna, additional, Jankauskiene, Augustina, additional, Miteva, Polina, additional, Emirova, Khadizha, additional, Bayazit, Aysun K., additional, Mache, Christoph J., additional, Sánchez-Moreno, Ana, additional, Harambat, Jérôme, additional, Groothoff, Jaap W., additional, Jager, Kitty J., additional, Schaefer, Franz, additional, Verrina, Enrico, additional, Shtiza, D., additional, Kramar, R., additional, Oberbauer, R., additional, Baiko, S., additional, Sukalo, A., additional, van Hoeck, K., additional, Collart, F., additional, des Grottes, J.M., additional, Pokrajac, D., additional, Roussinov, D., additional, Batinić, D., additional, Lemac, M., additional, Slavicek, J., additional, Seeman, T., additional, Vondrak, K., additional, Heaf, J.G., additional, Toots, U., additional, Finne, P., additional, Grönhagen-Riska, C., additional, Couchoud, C., additional, Lasalle, M., additional, Sahpazova, E., additional, Abazi, N., additional, Ristoka Bojkovska, N., additional, von Gersdorff, G., additional, Scholz, C., additional, Tönshoff, B., additional, Krupka, K., additional, Höcker, B., additional, Pape, L., additional, Afentakis, N., additional, Kapogiannis, A., additional, Printza, N., additional, Reusz, G., additional, Berecki, C.S., additional, Szabó, A., additional, Szabó, T., additional, Györke, Z.S., additional, Kis, E., additional, Palsson, R., additional, Edvardsson, V., additional, Gianoglio, B., additional, Maringhini, S., additional, Pecoraro, C., additional, Picca, S., additional, Testa, S., additional, Rudaitis, S., additional, Said-Conti, V., additional, Gatcan, S., additional, Berbeca, O., additional, Zaikova, N., additional, Pavićević, S., additional, Leivestad, T., additional, Zagozdzon, I., additional, Mota, C., additional, Almeida, M., additional, Afonso, C., additional, Mircescu, G., additional, Garneata, L., additional, Molchanova, E.A., additional, Tomilina, N.A., additional, Bikbov, B.T., additional, Kostic, M., additional, Peco-Antic, A., additional, Spasojevic-Dimitrijeva, B., additional, Milosevski-Lomic, G., additional, Paripovic, D., additional, Puric, S., additional, Kruscic, D., additional, Podracka, L., additional, Kolvek, G., additional, Buturovic-Ponikvar, J., additional, Novljan, G., additional, Battelino, N., additional, Alonso Melgar, A., additional, Schön, S., additional, Prütz, K.G., additional, Backmän, L., additional, Stendahl, M., additional, Evans, M., additional, Rippe, B., additional, Kuenhi, C.E., additional, Maurer, E., additional, Laube, G.F., additional, Tschumi, S., additional, Parvex, P., additional, Hoitsma, A., additional, Hemke, A., additional, Topaloglu, R., additional, Ivanov, D., additional, Pruthi, R., additional, Braddon, F., additional, Mannings, S., additional, Cassula, A., additional, and Sinha, M.D., additional

Published
2017
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5. Kidney Versus Combined Kidney and Liver Transplantation in Young People With Autosomal Recessive Polycystic Kidney Disease: Data From the European Society for Pediatric Nephrology/European Renal Association−European Dialysis and Transplant (ESPN/ERA-EDTA) Registry

Author

Mekahli, Djalila, primary, van Stralen, Karlijn J., additional, Bonthuis, Marjolein, additional, Jager, Kitty J., additional, Balat, Ayşe, additional, Benetti, Elisa, additional, Godefroid, Nathalie, additional, Edvardsson, Vidar O., additional, Heaf, James G., additional, Jankauskiene, Augustina, additional, Kerecuk, Larissa, additional, Marinova, Svetlana, additional, Puteo, Flora, additional, Seeman, Tomas, additional, Zurowska, Aleksandra, additional, Pirenne, Jacques, additional, Schaefer, Franz, additional, Groothoff, Jaap W., additional, Levtchenko, E., additional, Haffner, D., additional, Bjerre, A., additional, Massy, Z., additional, Shtiza, D., additional, Kramar, R., additional, Oberbauer, R., additional, Baiko, S., additional, Sukalo, A., additional, van Hoeck, K., additional, Collart, F., additional, des Grottes, J.M., additional, Pokrajac, D., additional, Roussinov, D., additional, Batinić, D., additional, Lemac, M., additional, Slavicek, J., additional, Seeman, T., additional, Vondrak, K., additional, Heaf, J.G., additional, Toots, U., additional, Finne, P., additional, Grönhagen-Riska, C., additional, Couchoud, C., additional, Lasalle, M, additional, Sahpazova, E, additional, Abazi, N, additional, Ristoka Bojkovska, N, additional, von Gersdorff, G, additional, Scholz, C, additional, Tönshoff, B, additional, Krupka, K, additional, Höcker, B, additional, Pape, L, additional, Afentakis, N, additional, Kapogiannis, A, additional, Printza, N, additional, Reusz, G, additional, Berecki, Cs, additional, Szabó, A, additional, Szabó, T, additional, Györke, Z.S., additional, Kis, E., additional, Palsson, R., additional, Edvardsson, V., additional, Gianoglio, B., additional, Maringhini, S., additional, Pecoraro, C., additional, Picca, S., additional, Testa, S., additional, Vidal, E., additional, Verrina, E., additional, Jankauskiene, A., additional, Pundziene, B., additional, Said-Conti, V., additional, Gatcan, S., additional, Berbeca, O., additional, Zaikova, N., additional, Pavićević, S., additional, Leivestad, T., additional, Zurowska, A., additional, Zagozdzon, I., additional, Mota, C., additional, Almeida, M., additional, Afonso, C., additional, Mircescu, G., additional, Garneata, L., additional, Molchanova, E.A., additional, Tomilina, N.A., additional, Bikbov, B.T., additional, Kostic, M., additional, Peco-Antic, A., additional, Spasojevic-Dimitrijeva, B., additional, Milosevski-Lomic, G., additional, Paripovic, D., additional, Puric, S., additional, Kruscic, D., additional, Podracka, L., additional, Kolvek, G., additional, Buturovic-Ponikvar, J., additional, Novljan, G., additional, Battelino, N., additional, Alonso Melgar, A., additional, Schön, S., additional, Prütz, K.G., additional, Backmän, L., additional, Stendahl, M., additional, Evans, M., additional, Rippe, B., additional, Kuenhi, C.E., additional, Maurer, E., additional, Laube, G.F., additional, Tschumi, S., additional, Parvex, P., additional, Hoitsma, A., additional, Hemke, A., additional, Topaloglu, R., additional, Duzova, A., additional, Ivanov, D., additional, Pruthi, R., additional, Braddon, F., additional, Mannings, S., additional, Cassula, A., additional, and Sinha, M.D., additional

Published
2016
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6. Paediatric nephrology

Author

Shi, H., primary, Wen, J., additional, LI, Z., additional, Elsayed, M., additional, Kamal, K., additional, Shi, H., additional, El Shal, A., additional, Youssef, D., additional, Caubet, C., additional, Lacroix, C., additional, Benjamin, B., additional, Bandin, F., additional, Bascands, J.-L., additional, Monsarrat, B., additional, Decramer, S., additional, Schanstra, J., additional, Laetitia, D.-B., additional, Ulinski, T., additional, Aoun, B., additional, Ozdemir, K., additional, Dincel, N., additional, Sozeri, B., additional, Mir, S., additional, Berdeli, A., additional, Akyigit, F., additional, Mizerska-Wasiak, M., additional, Panczyk-Tomaszewska, M., additional, Szymanik-Grzelak, H., additional, Roszkowska-Blaim, M., additional, Jamin, A., additional, Dehoux, L., additional, Monteiro, R. C., additional, Deschenes, G., additional, Bouts, A., additional, Davin, J.-C., additional, Dorresteijn, E., additional, Schreuder, M., additional, Lilien, M., additional, Oosterveld, M., additional, Kramer, S., additional, Gruppen, M., additional, Pintos-Morell, G., additional, Ramaswami, U., additional, Parini, R., additional, Rohrbach, M., additional, Kalkum, G., additional, Beck, M., additional, Carter, M., additional, Antwi, S., additional, Callegari, J., additional, Kotanko, P., additional, Levin, N. W., additional, Rumjon, A., additional, Macdougall, I. C., additional, Turner, C., additional, Booth, C. J., additional, Goldsmith, D., additional, Sinha, M. D., additional, Camilla, R., additional, Loiacono, E., additional, Donadio, M. E., additional, Conrieri, M., additional, Bianciotto, M., additional, Bosetti, F. M., additional, Peruzzi, L., additional, Conti, G., additional, Bitto, A., additional, Amore, A., additional, Coppo, R., additional, Maldyk, J., additional, Chou, H.-H., additional, Chiou, Y.-Y., additional, Bochniewska, V., additional, Jobs, K., additional, Jung, A., additional, Fallahzadeh Abarghooei, M. H., additional, Zare, J., additional, Sedighi Goorabi, V., additional, Derakhshan, A., additional, Basiratnia, M., additional, Fallahzadeh Abarghooei, M. A., additional, Hosseini Al-Hashemi, G., additional, Fallahzadeh Abarghooei, F., additional, Kluska-Jozwiak, A., additional, Soltysiak, J., additional, Lipkowska, K., additional, Silska, M., additional, Fichna, P., additional, Skowronska, B., additional, Stankiewicz, W., additional, Ostalska-Nowicka, D., additional, Zachwieja, J., additional, Girisgen, L., additional, Sonmez, F., additional, Yenisey, C., additional, Kis, E., additional, Cseprekal, O., additional, Kerti, A., additional, Szabo, A., additional, Salvi, P., additional, Benetos, A., additional, Tulassay, T., additional, Reusz, G., additional, Makulska, I., additional, Szczepanska, M., additional, Drozdz, D., additional, Zwolnska, D., additional, Tolstova, E., additional, Anis, L., additional, Alber, B., additional, Edouard, B., additional, Gerard, C., additional, Seni, K., additional, Dunia Julienne Hadiza, T., additional, Christian, S., additional, Benoit, T., additional, Francois, B., additional, Adama, L., additional, Rosenberg, A., additional, Munro, J., additional, Murray, K., additional, Wainstein, B., additional, Ziegler, J., additional, Singh-Grewal, D., additional, Boros, C., additional, Adib, N., additional, Elliot, E., additional, Fahy, R., additional, Mackie, F., additional, Kainer, G., additional, Polak-Jonkisz, D., additional, Zwolinska, D., additional, Laszki-Szczachor, K., additional, Janocha, A., additional, Rusiecki, L., additional, Sobieszczanska, M., additional, Garzotto, F., additional, Ricci, Z., additional, Clementi, A., additional, Cena, R., additional, Kim, J. C., additional, Zanella, M., additional, Ronco, C., additional, Purzyc, L., additional, Peco-Antic, A., additional, Kotur-Stevuljevic, J., additional, Paripovic, D., additional, Scekic, G., additional, Milosevski-Lomic, G., additional, Bogicevic, D., additional, Spasojevic-Dimitrijeva, B., additional, Hassan, R., additional, El-Husseini, A., additional, Sobh, M., additional, Ghoneim, M., additional, Harambat, J., additional, Bonthuis, M., additional, Van Stralen, K. J., additional, Ariceta, G., additional, Battelino, N., additional, Jahnukainen, T., additional, Sandes, A. R., additional, Combe, C., additional, Jager, K. J., additional, Verrina, E., additional, Schaefer, F., additional, Espindola, R., additional, Bacchetta, J., additional, Cochat, P., additional, Stefanis, C., additional, Leroy, S., additional, Fernandez-Lopez, A., additional, Nikfar, R., additional, Romanello, C., additional, Bouissou, F., additional, Gervaix, A., additional, Gurgoze, M., additional, Bressan, S., additional, Smolkin, V., additional, Tuerlinkx, D., additional, Stefanidis, C., additional, Vaos, G., additional, Leblond, P., additional, Gungor, F., additional, Gendrel, D., additional, Chalumeau, M., additional, Rawlins, D., additional, Simpson, J. M., additional, Arnaud, G., additional, Anne, M., additional, Stephanie, T., additional, Flavio, B., additional, Veronique, F. B., additional, Stephane, D., additional, Mumford, L., additional, Marks, S., additional, Ahmad, N., additional, Maxwell, H., additional, Tizard, J., additional, Vidal, E., additional, Amigoni, A., additional, Varagnolo, M., additional, Benetti, E., additional, Ghirardo, G., additional, Brugnolaro, V., additional, Murer, L., additional, Christine, G., additional, Degi, A., additional, Szabo, A. J., additional, Reusz, G. S., additional, Vidoni, A., additional, Ramondo, G., additional, and Miotto, D., additional

Published
2012
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7. Gender Disparities in Access to Pediatric Renal Transplantation in Europe: Data From the ESPN/ERA‐EDTA Registry

Author

Hogan, J., Couchoud, C., Bonthuis, M., Groothoff, J. W., Jager, K. J., Schaefer, F., Van Stralen, K. J., Shitza, D., Kramar, R., Oberbauer, R., Baiko, S., Sukalo, A., Hoeck, K., Collart, F., Grottes, J. M., Pokrajac, D., Resić, H., Prnjavorac, B., Roussinov, D., Batinić, D., Lemac, M., Slavicek, J., Seeman, T., Vondrak, K., Heaf, J. G., Toots, U., Finne, P., Grönhagen‐Riska, C., Lasalle, M., Sahpazova, E., Gersdorf, G., Barth, C., Scholz, C., Tönshoff, B., Ioannidis, G., Kapogiannis, A., Papachristou, F., Reusz, G., Túri, S., Szabó, L., Szabó, T., Györke, Z. S., Kis, E., Palsson, R., Edvardsson, V., Gianoglio, B., Palo, T., Pecoraro, C., Picca, S., Testa, S., Vidal, E., Mencarelli, F., Jankauskiene, A., Pundziene, B., Said‐Conti, V., Gatcan, S., Berbeca, O., Zaikova, N., Pavićević, S., Leivestad, T., Bjerre, A., Zurowska, A., Zagozdzon, I., Mota, C., Almeida, M., Afonso, C., Mircescu, G., Garneata, L., Podgoreanu, E., Molchanova, E. A., Tomilina, N. A., Bikbov, B. T., Kostic, M., Peco‐Antic, A., Puric, S., Kruscic, D., Spasojevic‐Dimitrijeva, B., Milosecski‐Lomic, G., Paripovic, D., Podracka, L., Kolvek, G., Buturovic‐Ponikvar, J., Novljan, G., Battelino, N., Alonso Melgar, A., Schön, S., Prütz, K. G., Seeberger, A., Backmän, L., Evans, M., Kuenhi, C. E., Maurer, E., Laube, G., Simometi, G., Hoitsma, A., Hemke, A., Topaloglu, R., Duzova, A., Ivanov, D., and Sinha, M.

Abstract

Inequalities between genders in access to transplantation have been demonstrated. We aimed to validate this gender inequality in a large pediatric population and to investigate its causes. This cohort study included 6454 patients starting renal replacement therapy before 18 years old, in 35 countries participating in the European Society for Paediatric Nephrology/European Renal Association–European Dialysis and Transplant Association Registry. We used cumulative incidence competing risk and proportional hazards frailty models to study the time to receive a transplant and hierarchical logistic regression to investigate access to preemptive transplantation. Girls had a slower access to renal transplantation because of a 23% lower probability of receiving preemptive transplantation. We found a longer follow‐up time before renal replacement therapy in boys compared with girls despite a similar estimated glomerular filtration rate at first appointment. Girls tend to progress faster toward end‐stage renal disease than boys, which may contribute to a shorter time available for pretransplantation workup. Overall, medical factors explained only 70% of the gender difference. In Europe, girls have less access to preemptive transplantation for reasons that are only partially related to medical factors. Nonmedical factors such as patient motivation and parent and physician attitudes toward transplantation and organ donation may contribute to this inequality. Our study should raise awareness for the management of girls with renal diseases. This large European study finds an association between female gender and a delay in access to renal transplantation in children, explained by a lower rate of pre‐emptive transplantation in girls, and explores other potential explanations for this gender inequality.

Published
2016
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8. Copy number variation analysis identifies MIR9-3 and MIR1299 as novel miRNA candidate genes for CAKUT.

Author

Zivotic I, Kolic I, Cvetkovic M, Spasojevic-Dimitrijeva B, Zivkovic M, Stankovic A, and Jovanovic I

Subjects
Humans, Male, Female, Child, Child, Preschool, Urogenital Abnormalities genetics, Infant, Genetic Predisposition to Disease, Vesico-Ureteral Reflux genetics, Case-Control Studies, MicroRNAs genetics, DNA Copy Number Variations
Abstract

Background: Congenital anomalies of the kidney and urinary tract (CAKUT) represent a frequent cause of pediatric kidney failure. CNVs, as a major class of genomic variations, can also affect miRNA regions. Common CNV corresponding miRNAs (cCNV-miRNAs) are functional variants regulating crucial processes which could affect urinary system development. Thus, we hypothesize that cCNV-miRNAs are associated with CAKUT occurrence and its expressivity., Methods: The extraction and filtering of common CNVs, identified in control samples deposited in publicly available databases gnomAD v2.1 and dbVar, were coupled with mapping of miRNA sequences using UCSC Genome Browser. After verification of the mapped miRNAs using referent miRBase V22.1, prioritization of cCNV-miRNA candidates has been performed using bioinformatic annotation and literature research. Genotyping of miRNA gene copy numbers for MIR9-3, MIR511, and MIR1299, was conducted on 221 CAKUT patients and 192 controls using TaqMan™ technology., Results: We observed significantly different MIR9-3 and MIR1299 gene copy number distribution between CAKUT patients and controls (Chi-square, P = 0.006 and P = 0.0002, respectively), while difference of MIR511 copy number distribution showed nominal significance (Chi-square, P = 0.027). The counts of less and more than two of MIR1299 copy numbers were more frequent within CAKUT patients compared to controls (P = 0.01 and P = 0.008, respectively) and also in cohort of patients with anomalies of the urinary tract compared to controls (P = 0.016 and P = 0.003, respectively)., Conclusions: Copy number variations of miRNA genes represent a novel avenue in clarification of the inheritance complexity in CAKUT and provide potential evidence about the association of common genetic variation with CAKUT phenotypes., (© 2024. The Author(s), under exclusive licence to International Pediatric Nephrology Association.)

Published
2024
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9. Kidney Transplantation in Small Children: Association Between Body Weight and Outcome-A Report From the ESPN/ERA-EDTA Registry.

Author

Boehm M, Bonthuis M, Aufricht C, Battelino N, Bjerre A, Edvardsson VO, Herthelius M, Hubmann H, Jahnukainen T, de Jong H, Laube GF, Mattozzi F, Molchanova EA, Muñoz M, Noyan A, Pape L, Printza N, Reusz G, Roussey G, Rubik J, Spasojevic'-Dimitrijeva B, Seeman T, Ware N, Vidal E, Harambat J, Jager KJ, and Groothoff J

Subjects
Body Weight, Child, Edetic Acid, Graft Survival, Humans, Registries, Kidney Failure, Chronic diagnosis, Kidney Failure, Chronic surgery, Kidney Transplantation adverse effects
Abstract

Background: Many centers accept a minimum body weight of 10 kg as threshold for kidney transplantation (Tx) in children. As solid evidence for clinical outcomes in multinational studies is lacking, we evaluated practices and outcomes in European children weighing below 10 kg at Tx., Methods: Data were obtained from the European Society of Paediatric Nephrology/European Renal Association and European Dialysis and Transplant Association Registry on all children who started kidney replacement therapy at <2.5 y of age and received a Tx between 2000 and 2016. Weight at Tx was categorized (<10 versus ≥10 kg) and Cox regression analysis was used to evaluate its association with graft survival., Results: One hundred of the 601 children received a Tx below a weight of 10 kg during the study period. Primary renal disease groups were equal, but Tx <10 kg patients had lower pre-Tx weight gain per year (0.2 versus 2.1 kg; P < 0.001) and had a higher preemptive Tx rate (23% versus 7%; P < 0.001). No differences were found for posttransplant estimated glomerular filtration rates trajectories (P = 0.23). The graft failure risk was higher in Tx <10 kg patients at 1 y (graft survival: 90% versus 95%; hazard ratio, 3.84; 95% confidence interval, 1.24-11.84), but not at 5 y (hazard ratio, 1.71; 95% confidence interval, 0.68-4.30)., Conclusions: Despite a lower 1-y graft survival rate, graft function, and survival at 5 y were identical in Tx <10 kg patients when compared with Tx ≥10 kg patients. Our results suggest that early transplantation should be offered to a carefully selected group of patients weighing <10 kg., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2022
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10. Association between pet-keeping and asthma in school children.

Author

Medjo B, Atanaskovic-Markovic M, Nikolic D, Spasojevic-Dimitrijeva B, Ivanovski P, and Djukic S

Subjects
Adolescent, Animals, Asthma epidemiology, Asthma immunology, Cats, Child, Dogs, Female, Follow-Up Studies, Humans, Incidence, Male, Prospective Studies, Risk Factors, Serbia epidemiology, Skin Tests, Surveys and Questionnaires, Allergens immunology, Asthma etiology, Pets immunology
Abstract

Background: The role of pet exposure in childhood asthma and allergy is still controversial. The aim of this study was to investigate the association between pet-keeping during different periods of childhood and asthma and sensitization in school children., Methods: One hundred and forty-nine children aged between 7 and 14 years were enrolled in this study. Seventy-four children had current physician-diagnosed asthma, while 75 children did not have asthma. Pet-keeping was investigated by questionnaire. Allergic sensitization to pet allergen was assessed on skin prick tests and specific serum IgE concentration. Logistic regression analysis was performed, taking into account potential confounders., Results: Early, past and current pet-keeping was not significantly associated with asthma. Neither owning a cat nor dog during childhood was associated with asthma. Early pet-keeping, however, was significantly associated with sensitization to pet allergens (adjusted odds ratio [aOR], 24.11; 95% confidence interval [CI]: 3.28-177.27). Further analysis showed that only early cat-keeping was significantly associated with sensitization to cat allergen (aOR, 51.59; 95%CI: 2.28-1167.07). Keeping a cat or a dog after the first year of life was not associated with sensitization to those allergens., Conclusions: Keeping a cat or a dog does not increase risk for asthma. Keeping a cat in the first year of life, however, increases risk of sensitization to cat allergen. Considering that this is a relatively small study, larger, prospective, birth cohort studies are required in Serbia to accurately assess the relationship between pet-keeping, asthma and sensitization., (© 2013 The Authors. Pediatrics International © 2013 Japan Pediatric Society.)

Published
2013
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