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The article reviews the theatrical productions "The Threepenny Opera," "Life of Galileo" and "The Parasite," performed at the Staatsschauspiel Dresden in Germany in June 2013.

The article discusses the launch of the public appeal for a sculpture to honor the memory of the deceased famous theatre director and writer Joan Littlewood. The engagement of Theater Royal Stratford East in East End, London in England is mentioned. The success of Littlewood's theatrical production "Oh, What a Lovely War!" is highlighted.

The article reviews the theatrical production "Mercy Killers," written and performed by Michael Mulligan at Van Fleet Theater in Columbus, Ohio from February 20 to March 10, 2013.

Objective To measure nursing workload and timely completion of essential tasks in relation to the staffi ng levels recommended by the British Association of Perinatal Medicine (BAPM) in Staffordshire, Shropshire and Black Country Newborn Network. Methods A prospective observational study was conducted measuring the time taken by selected nurses to undertake the necessary tasks for babies receiving different levels of care in the Network's six constituent neonatal units. An independent observer was used. The unit and individual's workload was evaluated against BAPM standards. Delays in essential predetermined tasks were recorded. The impact on quantity of care given and on the number of delayed tasks were compared between those with the recommended workload or less and those overstretched. Results Between October 2008 and February 2009, 89 nurses were observed caring for 244 neonates over 534 h. 54% of nursing shifts failed to meet BAPM standards. Nurses with workload greater than the BAPM-recommended levels demonstrated a 28% decrease in median time spent on clinical care per baby. 92 (17%) essential tasks were delayed >1 h or not done. Delays/omissions were more likely when BAPM standards were not met (53% vs 40%, p=0.049). In nursing observations without delays/omissions, accommodating for adequate nursing breaks and working in the same area, nurses could cater for no more than 1.2, 1.5 and 2.7 babies in intensive care, high dependency care and special care, respectively. Conclusion Understaffi ng leads to measurable problems including delays to essential treatment and reduced clinical care. BAPM standards are not aspirational and should be regarded as a minimum. Further research on optimising nursing care effi ciency with limited nursing resources is necessary. INSETS: What is already known on this topic;What this study adds. [ABSTRACT FROM AUTHOR]

Uncovering pathways underlying drug-induced toxicity is a fundamental objective in the field of toxicogenomics. Developing mechanism-based toxicity biomarkers requires the identification of such novel pathways and the order of their sufficiency in causing a phenotypic response. Genome-wide RNA interference (RNAi) phenotypic screening has emerged as an effective tool in unveiling the genes essential for specific cellular functions and biological activities. However, eliciting the relative contribution of and sufficiency relationships among the genes identified remains challenging. In the rodent, the most widely used animal model in preclinical studies, it is unrealistic to exhaustively examine all potential interactions by RNAi screening. Application of existing computational approaches to infer regulatory networks with biological outcomes in the rodent is limited by the requirements for a large number of targeted permutations. Therefore, we developed a two-step relay method that requires only one targeted perturbation for genome-wide de novo pathway discovery. Using expression profiles in response to small interfering RNAs (siRNAs) against the gene for peroxisome proliferator-activated receptor α (Ppara), our method unveiled the potential causal sufficiency order network for liver hypertrophy in the rodent. The validity of the inferred 16 causal transcripts or 15 known genes for PPARα-induced liver hypertrophy is supported by their ability to predict non-PPAR-induced liver hypertrophy with 84% sensitivity and 76% specificity. Simulation shows that the probability of achieving such predictive accuracy without the inferred causal relationship is exceedingly small (p , 0.005). Five of the most sufficient causal genes have been previously disrupted in mouse models; the resulting phenotypic changes in the liver support the inferred causal roles in liver hypertrophy. Our results demonstrate the feasibility of defining pathways mediating drug-induced toxicity from siRNA-treated expression profiles. When combined with phenotypic evaluation, our approach should help to unleash the full potential of siRNAs in systematically unveiling the molecular mechanism of biological events. [ABSTRACT FROM AUTHOR]

Focuses on medical-related issues in Great Britain. Changes in community pediatrics in Nottingham; Problem of anticoagulant treatment with control; Toxic effects of chemotherapeutic agents on spermatogenesis.

The article offers information on playwright Manfred Karge, writting plays about working-class struggles and his time at the Berliner Ensemble theatre. Topics discussed include revival of his play "Man to Man" at the 2015 Edinburgh Festival; influence of playwright Bertolt Brecht on him; and relevancy of Brecht's idea of epic theatre.

The article reviews the theatrical production "A Man's a Man," directed by Brian Kulick, performed at Classic Stage Company in New York from January 10 to February 16, 2013.