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Background: Experts estimate that in up to 10% of the infected, SARS-CoV-2 would cause persistent symptoms, activity limitations and reduced quality of life. Referred to as long COVID, these conditions might, in the future, specifically impact German-speaking countries due to their higher rates of unvaccinated people compared to other Western countries. Accurate measurement of symptom burden and its consequences is needed to manage conditions such as long COVID, and several tools have been developed to do so. However, no patient-reported instrument existed in the German language at the time of writing., Objective: This study, therefore, aimed to develop a German version of the COVID-19 Yorkshire Rehabilitation Scale (C19-YRS)., Methods: We conducted a translation and qualitative evaluation, including cultural adaptation, of the C19-YRS and assessed its face validity. After creating a preliminary version, 26 individuals (14 women [53%]) participated in cognitive interviews (January 2022 to March 2022). Using cognitive debriefing interviews, we ensured the content's comprehensibility. The matrix-framework method guided the qualitative data analysis., Results: Compared to the original English version, adaptations were necessary, resulting in changes to the introductory text, while the items for recording persistent symptoms were hardly changed., Conclusion: The German version of the C19-YRS is expected to support standardized long COVID care., Competing Interests: TS has received grant/research support from AbbVie and Roche, has been a consultant for AbbVie and Sanofi Genzyme, and has been a paid speaker for AbbVie, Novartis, Roche, Sanofi, and Takeda. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (Copyright © 2024 Sperl, Stamm, Mosor, Ritschl, Sivan, Hoffmann and Gantschnig.)

Objective: The objective of this study was to analyse the narrative life stories of children with end-stage kidney disease (ESKD) and their families to determine how health professionals can effectively support these children to achieve better life outcomes., Design: Qualitative narrative biographic study., Setting: We invited every long-term survivor of paediatric kidney transplants and their families at the Medical University of Vienna between 2008 and 2013 to participate in this study., Participants: Nineteen patients (women: n=8, 42%) and 34 family members (women: n=22, 65%) were interviewed. The patients had a mean age of 7.6 (SD±5.6) years at the time of transplantation and 22.2 (SD±5.4) at the time of interview., Main Outcomes Measures: A qualitative narrative biographical analysis was combined with computational structured topic models using the Latent Dirichlet Allocation., Results: The overarching finding was the desire for normality in daily life in long-term survivors and their families but with different perceptions of what normality looks like and predominance of this aspect evolving. Different strategies were used by patients (focused on their advancement) and caregivers (normality for all family members). Siblings played a major role in supporting survivors' social inclusion., Conclusions: The strong desire for normality confirms recent findings of the Standardised Outcomes in Nephrology Group initiative, which proposes survival and life participation as core outcomes in children with chronic kidney disease. Our study should be a starting point for an international effort to identify typologies and stratified interventions for children with ESKD and their families, particularly siblings., Competing Interests: Competing interests: TS reports grants and personal fees from AbbVie, grants and personal fees from Roche and personal fees from Sanofi, Takeda and Novartis outside the submitted work. All other authors declare: No financial or non-financial benefits have been or will be received from any party related to the article's subject., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Background: Ongoing education of health professionals in rheumatology (HPR) is critical for high-quality care. An essential factor is education readiness and a high quality of educational offerings. We explored which factors contributed to education readiness and investigated currently offered postgraduate education, including the European Alliance of Associations for Rheumatology (EULAR) offerings., Methods and Participants: We developed an online questionnaire, translated it into 24 languages and distributed it in 30 European countries. We used natural language processing and the Latent Dirichlet Allocation to analyse the qualitative experiences of the participants as well as descriptive statistics and multiple logistic regression to determine factors influencing postgraduate educational readiness. Reporting followed the Checklist for Reporting Results of Internet E-Surveys guideline., Results: The questionnaire was accessed 3589 times, and 667 complete responses from 34 European countries were recorded. The highest educational needs were 'professional development', 'prevention and lifestyle intervention'. Older age, more working experience in rheumatology and higher education levels were positively associated with higher postgraduate educational readiness. While more than half of the HPR were familiar with EULAR as an association and the respondents reported an increased interest in the content of the educational offerings, the courses and the annual congress were poorly attended due to a lack of awareness, comparatively high costs and language barriers., Conclusions: To promote the uptake of EULAR educational offerings, attention is needed to increase awareness among national organisations, offer accessible participation costs, and address language barriers., Competing Interests: Competing interests: VR, LS, MRRA, MB, CB, JC, TD, JdlT, AdT, AD, FE-L, RJOF, GEF, JG, KK, MLK, CM-B, AM, JM, RHM, ElM, ErM, CN-S: no competing interest to declare. RD: Speaker fees from Abbvie, Elly Lilly, EwoPharma, Sandoz, and Novartis, all outside the submitted work., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Recent research on time perception has revealed that actions which are replayed in slow motion are perceived to take longer and rated to be more intentional (e.g., foul plays). Interestingly, the bias on duration estimations seems to disappear when information on the slow motion factor (i.e., the degree the video was slowed down) was provided. Here, we scrutinize the question whether also the intentionality bias disappears when explicit information about the slow motion factor is provided. To this end, two groups watched the same video clips, all displaying foul situations in a basketball match, in different video speeds. While the uninformed group saw the videos without further information, the informed group received additional information about the current slow motion factor. This study replicated the overestimation of original duration with increasing slow motion and indicated that this effect might be reduced when information about the slow motion factor is provided. However, despite generally lower intentionality ratings in the informed group, video speed information was not able to reduce the rise in intentionality ratings with increasing slow motion. Potential reasons and open questions regarding the nature and mechanisms behind these perceptual temporal biases (e.g., different time processing systems) are discussed.

Background: On January 30, 2020, the World Health Organization Emergency Committee declared the rapid worldwide spread of COVID-19 a global health emergency. By December 2020, the safety and efficacy of the first COVID-19 vaccines had been demonstrated. However, international vaccination coverage rates have remained below expectations (in Europe at the time of manuscript submission). Controversial mandatory vaccination is currently being discussed and has already been introduced in some countries (Austria, Greece, and Italy). We used the Twitter survey system as a viable method to quickly and comprehensively gather international public health insights on mandatory vaccination against COVID-19., Objective: The purpose of this study was to better understand the public's perception of mandatory COVID-19 vaccination in real time using Twitter polls., Methods: Two Twitter polls were developed (in the English language) to seek the public's opinion on the possibility of mandatory vaccination. The polls were pinned to the Digital Health and Patient Safety Platform's (based in Vienna, Austria) Twitter timeline for 1 week in mid-November 2021, 3 days after the official public announcement of mandatory COVID-19 vaccination in Austria. Twitter users were asked to participate and retweet the polls to reach the largest possible audience., Results: Our Twitter polls revealed two extremes on the topic of mandatory vaccination against COVID-19. Almost half of the 2545 respondents (n=1246, 49%) favor mandatory vaccination, at least in certain areas. This attitude contrasts with the 45.7% (n=1162) who categorically reject mandatory vaccination. Over one-quarter (n=621, 26.3%) of participating Twitter users said they would never get vaccinated, as reflected by the current Western European and North American vaccination coverage rate. Concatenating interpretation of these two polls should be done cautiously as participating populations might substantially differ., Conclusions: Mandatory vaccination against COVID-19 (in at least certain areas) is favored by less than 50%, whereas it is opposed by almost half of the surveyed Twitter users. Since (social) media strongly influences public perceptions and views, and social media discussions and surveys are specifically susceptible to the "echo chamber effect," the results should be interpreted as a momentary snapshot. Therefore, the results of this study need to be complemented by long-term surveys to maintain their validity., (©Valentin Ritschl, Fabian Eibensteiner, Erika Mosor, Maisa Omara, Lisa Sperl, Faisal A Nawaz, Chandragiri Siva Sai, Merisa Cenanovic, Hari Prasad Devkota, Mojca Hribersek, Ronita De, Elisabeth Klager, Eva Schaden, Maria Kletecka-Pulker, Sabine Völkl-Kernstock, Harald Willschke, Christoph Aufricht, Atanas G Atanasov, Tanja Stamm. Originally published in JMIR Formative Research (https://formative.jmir.org), 21.06.2022.)

Modifying already automatized movement skills often causes proactive interference resulting in initial performance decrements. Dealing with interference is closely linked to inhibitory functions, since inhibition is needed to suppress automatic, but undesired behavior. The aim of this study was to investigate the role of three different inhibition dimensions for interference control in motor skill change. To this end, 42 participants performed three tests each measuring a different dimension of inhibition: resistance to distractor interference (Eriksen-Flanker Task), resistance to proactive interference (Brown-Peterson Variant) and prepotent response inhibition (Stop-Signal Task). To examine the amount of proactive interference in a motor skill change task, participants were then asked to type a short paragraph as fast and accurately as possible on a regular computer keyboard. After this baseline measure, in order to induce proactive interference, they were confronted with a manipulated keyboard on which the letters S and L were switched. This change led to an immediate performance decline, observable in increased typing times and errors. Results also showed that larger performance decrements were significantly associated with better baseline performance, lower scores on prepotent response inhibition and higher scores on resistance to distractor interference. Besides supporting the idea of inhibition as a multidimensional construct, these findings replicate and confirm recent research indicating that the success in motor skill change is predicted by the ability to suppress prepotent response tendencies., (Copyright © 2021 Elsevier B.V. All rights reserved.)

When displayed in slow motion, actions are often perceived longer compared with original speed. However, it remains to be determined why this bias exists. Is it possible that the bias emerges because participants underestimate the factor by which a video was slowed down and hence arrive at erroneous conclusions about the original duration? If true, providing explicit information about the respective video speed should eliminate this slow motion effect. To scrutinize the nature of this bias, participants rated the original duration of sports actions displayed at original speed or slow motion. Results revealed the expected overestimation bias consisting in longer ratings with increasing slow motion. However, the bias disappeared when information about the current video speed was provided. The observations suggest an influence of knowledge about video playback speed on cognitive-evaluative processes which may hold important implications for future research and practice.

A membrane protein's oligomeric state modulates its functionality in various cellular processes. Since membrane proteins have to be solubilized in an appropriate membrane mimetic, the use of classical biophysical methods to analyze protein oligomers is challenging. We here present a method to determine the number of membrane proteins inserted into lipid nanodiscs. It is based on the ability to selectively quantify the amount of a small and robust fusion protein that can be proteolytically cleaved off from a membrane protein after incorporation into lipid nanodiscs. A detailed knowledge of the number of membrane proteins per nanodisc at defined assembly conditions is essential to estimate the tendency for oligomerization, but also for guiding sample optimization for structural investigations that require the presence of a homogenous oligomeric state. We show that this method can efficiently be used to determine the number of VDAC1 channels in nanodiscs at various assembly conditions, as confirmed by negative stain EM. The presented method is suitable in particular for membrane proteins that cannot be probed easily by other methods such as single span transmembrane helices. This assay can be applied to any membrane protein that can be incorporated into a nanodisc without the requirement for special instrumentation and will thus be widely applicable and complementary to other methods that quantify membrane protein insertion in lipid nanodiscs., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier B.V. All rights reserved.)

When modifying established, automatized skills, performers often experience proactive interference resulting in initial performance decrements. Notably, individuals seem to differ quite largely with respect to their interference susceptibility. The aim of the present study was to scrutinize the roots of these interindividual differences by examining the role of executive functions, age, baseline performance and gaze behavior applying a motor skill change task. As the ability to deal with proactive interference seems to be particularly linked to inhibitory mechanisms, we also assessed whether the application of a motor restriction which prevents unwanted movements may facilitate inhibition and hence result in less proactive interference. To this end, skilled touch-typists were confronted with a rule change that prohibited the left index finger for subsequent typing which immediately disrupted participants' automatized typing fluency. Regression analyses revealed that the amount of interference was significantly related to age and that the application of a motor restriction tended to predict less proactive interference. Additional correlation analyses revealed that a higher amount of proactive interference was also associated with higher baseline performance and lower prepotent response inhibition abilities. However, none of the remaining executive functions could explain the amount of interference. It follows that individual factors such as age, baseline performance and prepotent response inhibition as well as the physical option to execute a certain movement may play important roles in overcoming proactive interference when changing automatized skills., (Copyright © 2020 Elsevier B.V. All rights reserved.)

Changing automatized movement patterns often leads to initial performance decrements caused by proactive interference. In this study, we scrutinized whether proactive interference could be reduced by inhibiting the to-be-changed movement pattern by means of a physical movement constraint and verbal inhibition instructions, and whether any of the two interventions may be superior. Skilled typists typed short texts as fast and accurately as possible on a regular QWERTZ keyboard. After baseline measures, a new rule prohibiting the use of the left index finger was introduced. Subsequently, participants took part in either a verbal instruction or an additional motor restriction intervention phase. Results revealed that the original rule change was successful in inducing proactive interference in skilled typists. Most importantly, the two interventions similarly reduced proactive interference both immediately following the rule change and after ten practice sessions. We conclude that reducing proactive interference by means of physical motor restrictions and verbal instructions may be equally effective.