25 results on '"Spinal Curvatures drug therapy"'
Search Results
2. Botulinum Toxin for Axial Postural Abnormalities in Parkinson's Disease: A Systematic Review.
- Author
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Gandolfi M, Artusi CA, Imbalzano G, Camozzi S, Crestani M, Lopiano L, Tinazzi M, and Geroin C
- Subjects
- Humans, Neuromuscular Agents therapeutic use, Spinal Curvatures drug therapy, Posture, Parkinson Disease drug therapy, Botulinum Toxins therapeutic use
- Abstract
Axial postural abnormalities (APAs), characterized by their frequency, disabling nature, and resistance to pharmacological treatments, significantly impact Parkinson's disease and atypical Parkinsonism patients. Despite advancements in diagnosing, assessing, and understanding their pathophysiology, managing these complications remains a significant challenge. Often underestimated by healthcare professionals, these disturbances can exacerbate disability. This systematic review assesses botulinum toxin treatments' effectiveness, alone and with rehabilitation, in addressing APAs in Parkinson's disease, utilizing MEDLINE (PubMed), Web of Science, and SCOPUS databases for source material. Of the 1087 records retrieved, 16 met the selection criteria. Most research has focused on botulinum toxin (BoNT) as the primary treatment for camptocormia and Pisa syndrome, utilizing mostly observational methods. Despite dose and injection site variations, a common strategy was using electromyography-guided injections, occasionally enhanced with ultrasound. Patients with Pisa syndrome notably saw consistent improvements in APAs and pain. However, studies on the combined effects of botulinum toxin and rehabilitation are limited, and antecollis is significantly under-researched. These findings recommend precise BoNT injections into hyperactive muscles in well-selected patients by skilled clinicians, avoiding compensatory muscles, and underscore the necessity of early rehabilitation. Rehabilitation is crucial in a multidisciplinary approach to managing APAs, highlighting the importance of a multidisciplinary team of experts.
- Published
- 2024
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3. The Effects of Preoperative Steroid Therapy on Perioperative Morbidity and Mortality After Adult Spinal Deformity Surgery.
- Author
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White SJW, Ranson WA, Cho B, Cheung ZB, Ye I, Carrillo O, Kim JS, and Cho SK
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- Aged, Female, Humans, Male, Middle Aged, Morbidity, Perioperative Period, Preoperative Care methods, Preoperative Care statistics & numerical data, Retrospective Studies, Risk Factors, Orthopedic Procedures adverse effects, Orthopedic Procedures mortality, Orthopedic Procedures statistics & numerical data, Postoperative Complications epidemiology, Postoperative Complications mortality, Spinal Curvatures drug therapy, Spinal Curvatures epidemiology, Spinal Curvatures mortality, Spinal Curvatures surgery, Steroids therapeutic use
- Abstract
Study Design: Retrospective cohort analysis., Objectives: To identify the effects of preoperative steroid therapy on 30-day perioperative complications after adult spinal deformity (ASD) surgery., Summary of Background Data: Chronic steroid therapy has demonstrated therapeutic effects in the treatment of various medical conditions but is also known to be associated with surgical complications. There remains a gap in the literature regarding the impact of chronic steroid therapy in predisposing patients to perioperative complications after elective surgery for ASD., Methods: We performed a retrospective analysis of data from the 2008-2015 American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database. Patients were divided into two groups based on preoperative steroid therapy. Differences in baseline patient characteristics, comorbidities, and operative variables were assessed. Univariate analysis was performed to compare the incidence of perioperative complications. Multivariate stepwise logistic regression models were then used to adjust for baseline patient and operative variables in order to identify perioperative complications that were associated with preoperative steroid therapy., Results: We identified 7,936 patients who underwent surgery for ASD, of which 418 (5.3%) were on preoperative steroid therapy. Preoperative steroid therapy was an independent risk factor for four perioperative complications, including mortality (odds ratio [OR] 2.42, 95% confidence interval [CI] 1.30, 4.51; p = .005), wound dehiscence (OR 3.12, 95% CI 1.45, 6.70; p = .004), deep vein thrombosis (DVT) (OR 2.10, 95% CI 1.24, 3.55; p = .006), and blood transfusion (OR 1.34, 95% CI 1.08, 1.66; p < .007)., Conclusions: Patients on preoperative steroid therapy are at increased risk of 30-day mortality, wound dehiscence, DVT, and blood transfusion after surgery for ASD. An interdisciplinary approach to the perioperative management of steroid regimens is critical., Level of Evidence: Level III., (Copyright © 2019 Scoliosis Research Society. Published by Elsevier Inc. All rights reserved.)
- Published
- 2019
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4. Levodopa/carbidopa intestinal gel infusion can improve camptocormia in Parkinson's disease.
- Author
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Morales-Briceño H, Mahant N, Duma S, Martin A, Griffith J, Tsui D, and Fung VS
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- Aged, Carbidopa administration & dosage, Dopamine Agonists administration & dosage, Drug Combinations, Gels, Humans, Infusions, Parenteral, Levodopa administration & dosage, Male, Muscular Atrophy, Spinal etiology, Parkinson Disease complications, Spinal Curvatures etiology, Treatment Outcome, Carbidopa pharmacology, Dopamine Agonists pharmacology, Levodopa pharmacology, Muscular Atrophy, Spinal drug therapy, Parkinson Disease drug therapy, Spinal Curvatures drug therapy
- Published
- 2019
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5. Effect of subthalamic deep brain stimulation on posture in Parkinson's disease: A blind computerized analysis.
- Author
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Roediger J, Artusi CA, Romagnolo A, Boyne P, Zibetti M, Lopiano L, Espay AJ, Fasano A, and Merola A
- Subjects
- Adult, Aged, Dopamine metabolism, Humans, Male, Middle Aged, Muscular Atrophy, Spinal diagnosis, Parkinson Disease diagnosis, Posture physiology, Spinal Curvatures diagnosis, Subthalamic Nucleus physiopathology, Subthalamic Nucleus surgery, Deep Brain Stimulation methods, Levodopa therapeutic use, Muscular Atrophy, Spinal drug therapy, Parkinson Disease therapy, Spinal Curvatures drug therapy
- Abstract
Introduction: We sought to assess the effect of subthalamic deep brain stimulation (STN DBS) on Parkinson's disease (PD)-associated postural abnormalities., Methods: A computerized analysis of posture was used to quantify the thoracolumbar, thoracic, and cervical-occipital ventral angles, as well as the thoracolumbar and cervical-occipital lateral angles from the video-repository of three specialized movement disorder centers (n = 158 patients). Data was extracted from frames from video-recordings in the pre-surgical medication-ON (dopaminergic therapy) and post-surgical stimulation-ON/medication-ON states (STN DBS plus dopaminergic therapy). The sum of the five postural angles (global postural angle) was used to compare pre-vs. post-surgical trunk posture alterations. A multivariate analysis was used to examine the association between changes in the postural angles and demographic or clinical variables., Results: There was a 6.7% amelioration in the global postural angle between the pre- and post-surgical assessments (p = 0.031). Motor response to and pre-surgical dosage of levodopa, male gender, and shorter PD duration were identified as predictors for posture improvement after STN DBS. Cases meeting criteria for lower (n = 2) or upper (n = 1) camptocormia respectively improved by 48.1% in the ventral thoracolumbar angle (from 36.4 ± 0.0° to 18.9 ± 4.2°) and 13.8% in the ventral thoracic angle (from 49.1° to 42.3°). Cases meeting criteria for Pisa syndrome (n = 2) improved by 67.5% in the lateral thoracolumbar angle (from 16.9 ± 2.0° to 5.5 ± 4.7°)., Conclusions: STN DBS has a relatively small but significant effect on PD-associated postural abnormalities, potentially enhancing the effect of dopaminergic medications alone., (Copyright © 2019 Elsevier Ltd. All rights reserved.)
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- 2019
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6. An Unusual Cause of Camptocormia.
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Mehta S, Kumar R, and Lal V
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- Aged, Brain diagnostic imaging, Diabetes Complications, Diagnosis, Differential, Dyspepsia drug therapy, Female, Humans, Muscular Atrophy, Spinal diagnostic imaging, Muscular Atrophy, Spinal drug therapy, Parkinsonian Disorders diagnostic imaging, Parkinsonian Disorders drug therapy, Spinal Curvatures diagnostic imaging, Spinal Curvatures drug therapy, Sulpiride adverse effects, Dopamine Antagonists adverse effects, Muscular Atrophy, Spinal diagnosis, Muscular Atrophy, Spinal etiology, Parkinsonian Disorders diagnosis, Parkinsonian Disorders etiology, Spinal Curvatures diagnosis, Spinal Curvatures etiology, Sulpiride analogs & derivatives
- Abstract
Background: Camptocormia is defined as forward flexion of the spine that manifests during walking and standing and disappears in recumbent position. The various etiologies include idiopathic Parkinson's disease, multiple system atrophy, myopathies, degenerative joint disease, and drugs., Case Report: A 67-year-old diabetic female presented with bradykinesia and camptocormia that started 1 year prior to presentation. Evaluation revealed levosulpiride, a dopamine receptor blocker commonly used for dyspepsia, to be the culprit., Discussion: It is well known that dopamine receptor blockers cause parkinsonism and tardive syndromes. We report a rare and unusual presentation of camptocormia attributed to this commonly used gastrointestinal drug in the Asian population., Competing Interests: Funding: None. Conflicts of Interest: The authors report no conflicts of interest. Ethics Statement: All patients that appear on video have provided written informed consent; authorization for the videotaping and for publication of the videotape was provided.
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- 2019
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7. The influence of postural deformities on neck function and pain in patients with Parkinson's disease.
- Author
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Alwardat M, Schirinzi T, Di Lazzaro G, Franco D, Imbriani P, Sinibaldi Salimei P, Mercuri NB, and Pisani A
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- Aged, Aged, 80 and over, Cross-Sectional Studies, Disabled Persons, Female, Humans, Levodopa therapeutic use, Male, Middle Aged, Muscular Atrophy, Spinal drug therapy, Muscular Atrophy, Spinal epidemiology, Muscular Atrophy, Spinal physiopathology, Neck Pain diagnosis, Neck Pain epidemiology, Pain drug therapy, Pain epidemiology, Pain physiopathology, Parkinson Disease drug therapy, Parkinson Disease epidemiology, Pilot Projects, Spinal Curvatures drug therapy, Spinal Curvatures epidemiology, Spinal Curvatures physiopathology, Neck Pain physiopathology, Parkinson Disease physiopathology, Postural Balance physiology
- Abstract
Background: Trunk alignment is thought to contribute to neck function. However, this common assumption is not clear in patients with Parkinson's disease (PwPD) suffering from different postural deformities such as: Pisa syndrome (PS), Camptocormia & Antecollis (C&A)., Objectives: to investigate the effect of different postural deformities including PS and C&A on neck function and pain in patient (PwPD)., Methods: Forty-five participants belonging to three groups: 15 PD patients without postural disorders (PD), 15 with PS, and 15 with C&A. The function, disability and pain were assessed by Neck Disability Index (NDI), and Brief Pain Inventory (BPI) which used to assess the pain severity (BPI-PS) and Pain Interference (BPI-PI). All groups completed clinical assessments by the Unified Parkinson's Disease Rating Scale (UPDRS), Modified Hoenh & Yahr (mH&Y) staging and the Levodopa Equivalent Daily Dose (LEDD)., Results: PD group compared with PS and C&A groups showed differences in NDI, BPI-PS, BPI-PI, LEDD and mH&Y staging (P < 0.001), but no differences found in PD duration, UPDRS-II and III in the same groups. Moreover, no differences were observed between PS and C&A groups in the mentioned scales., Discussion and Conclusion: These results demonstrated that PS and C&A are associated with severe impairment of neck functions, and pain in PwPD.
- Published
- 2019
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8. Association of Patient-Reported Narcotic Use With Short- and Long-Term Outcomes After Adult Spinal Deformity Surgery: Multicenter Study of 425 Patients With 2-year Follow-up.
- Author
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Raad M, Jain A, Neuman BJ, Hassanzadeh H, Gupta MC, Burton DC, Mundis GM Jr, Lafage V, Klineberg EO, Hostin RA, Ames CP, Bess S, Sciubba DM, and Kebaish KM
- Subjects
- Adult, Aged, Back Pain drug therapy, Female, Humans, Male, Middle Aged, Pain Measurement, Postoperative Period, Prospective Studies, Spinal Curvatures drug therapy, Treatment Outcome, Back Pain surgery, Narcotics therapeutic use, Quality of Life, Spinal Curvatures surgery
- Abstract
Study Design: Retrospective analysis of a prospective registry OBJECTIVE.: To investigate associations of preoperative narcotic use with outcomes after adult spinal deformity (ASD) surgery., Summary of Background Data: We hypothesized that preoperative narcotic use would predict longer hospital stays, greater postoperative narcotic use, and greater disability 2 years after ASD surgery., Methods: A multicenter database of surgical ASD patients was analyzed retrospectively for patients with self-reported data on preoperative narcotic use. Patients were categorized as using narcotics daily or non-daily (including those who used no narcotics), according to self-report. Outcomes were prolonged length of hospital stay (LOS) (>7 days); length of intensive care unit (ICU) stay; and daily narcotic use and Oswestry Disability Index (ODI) scores 2 years postoperatively. Groups were compared by demographic characteristics, pain, disability, radiographic deformity, and surgical invasiveness. Multivariate logistic and linear regression were used to determine associations between preoperative narcotic use and outcomes., Results: Of 575 patients who met the inclusion criteria, 425 (74%) had complete 2-year follow-up data. Forty-four percent reported daily preoperative narcotic use. Compared with non-daily users, daily narcotic users were older, had more comorbidities, more severe back pain, higher ODI scores, longer operative times, and worse preoperative malalignment and were more likely to undergo 3-column osteotomy (all, P < 0.05). Daily narcotic use independently predicted prolonged LOS (odds ratio [OR] = 1.7, 95% confidence interval [CI] = 1.1-2.9), longer ICU stay (difference = 16 hours, 95% CI = 1.9-30 hours), and daily narcotic use 2 years postoperatively (OR = 6.9, 95% CI = 3.7-13), as well as worse 2-year ODI score (difference = 4.5, 95% CI: 0.7-8.3, P = 0.021)., Conclusion: Daily narcotic use before ASD surgery was associated with prolonged LOS, longer ICU stays, and increased risk of daily narcotic use and greater disability 2 years postoperatively., Level of Evidence: 3.
- Published
- 2018
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9. Metformin Inhibits Cyst Formation in a Zebrafish Model of Polycystin-2 Deficiency.
- Author
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Chang MY, Ma TL, Hung CC, Tian YC, Chen YC, Yang CW, and Cheng YC
- Subjects
- AMP-Activated Protein Kinases metabolism, Animals, Autophagy drug effects, Autophagy genetics, Cell Proliferation drug effects, Cloaca abnormalities, Cysts drug therapy, Cysts etiology, Disease Models, Animal, Kidney Tubules cytology, Leukocytes drug effects, Leukocytes metabolism, Polycystic Kidney, Autosomal Dominant drug therapy, Polycystic Kidney, Autosomal Dominant metabolism, Spinal Curvatures drug therapy, TRPP Cation Channels genetics, TRPP Cation Channels metabolism, Zebrafish, Cysts pathology, Metformin pharmacology, Polycystic Kidney, Autosomal Dominant genetics, Polycystic Kidney, Autosomal Dominant pathology, TRPP Cation Channels deficiency
- Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is a common kidney disease caused by mutations in PKD1 or PKD2. Metformin reduces cyst growth in mouse models of PKD1. However, metformin has not been studied in animal models of PKD2, and the cellular mechanism underlying its effectiveness is not entirely clear. This study investigated the effects of metformin on cyst formation in a zebrafish model of polycystin-2 deficiency resulting from morpholino knockdown of pkd2. We added metformin (2.5 to 20 mM) to the embryo media between 4 and 48 hours post fertilisation and observed pronephric cyst formation by using the wt1b promoter-driven GFP signal in Tg(wt1b:GFP) pkd2 morphants. Metformin inhibited pronephric cyst formation by 42-61% compared with the untreated controls. Metformin also reduced the number of proliferating cells in the pronephric ducts, the degree of dorsal body curvature, and the infiltration of leukocytes surrounding the pronephros. Moreover, metformin treatment increased the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) and enhanced autophagy in the pronephros. Our data suggest that metformin reduces cyst formation through activation of the AMPK pathway and modulation of defective cellular events such as proliferation and autophagy. These results also imply that metformin could have therapeutic potential for ADPKD treatment.
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- 2017
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10. Camptocormia as an onset symptom of myasthenia gravis.
- Author
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Sato T, Natori T, Hata T, Yamashiro N, Shindo K, and Takiyama Y
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- Aged, Diagnosis, Differential, Humans, Male, Muscular Atrophy, Spinal drug therapy, Myasthenia Gravis drug therapy, Spinal Curvatures drug therapy, Muscular Atrophy, Spinal diagnosis, Muscular Atrophy, Spinal etiology, Myasthenia Gravis complications, Myasthenia Gravis diagnosis, Spinal Curvatures diagnosis, Spinal Curvatures etiology
- Published
- 2017
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11. Treatment of Mild Camptocormia with Selegiline in Patients with Parkinson's Disease.
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Yoritaka A, Mori H, and Hattori N
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- Aged, Female, Humans, Male, Middle Aged, Muscular Atrophy, Spinal complications, Parkinson Disease complications, Spinal Curvatures complications, Treatment Outcome, Antiparkinson Agents therapeutic use, Muscular Atrophy, Spinal drug therapy, Parkinson Disease drug therapy, Selegiline therapeutic use, Spinal Curvatures drug therapy
- Abstract
Background: Camptocormia in Parkinson's disease (PD) is unresponsive to various therapies and induced difficulties in their day-to-day life., Objective: This study, an open trial, was aimed at assessing the efficacy of selegiline in the treatment of mild camptocormia in PD patients., Methods: Participants were administered 5 mg of selegiline for the first 8 weeks and 7.5 mg for the second 8 weeks., Results: As primary endpoints, the degree of thoracolumbar anteflexion decreased from 23.2° (mean) (11.8° (SD)) at baseline to 18.3° (7.1°) at 16 weeks, and the area of postural sway measured using a Gravicorder increased. However, the differences were not significant. Thoracolumbar anteflexion improved in 60% of the participants., Conclusions: In this study, 60% of the participants showed an improvement in anteflexion of the thoracolumbar spine with selegiline, but the change in the degree of anteflexion was 5°, which was not statistically significant. Participants with significant improvement in thoracolumbar anteflexion had an increased postural sway. This change was induced by a decrease in truncal muscle tonus or change in the center of gravity. This study combined the study of anteflexion and stability, and provides information on the treatment of short-term or mild camptocormia., (© 2016 S. Karger AG, Basel.)
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- 2016
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12. Camptocormia and Pisa syndrome as manifestations of acute myasthenia gravis exacerbation.
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Abboud H, Sivaraman I, Ontaneda D, and Tavee J
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- Aged, 80 and over, Electromyography methods, Humans, Immunoglobulins, Intravenous therapeutic use, Male, Muscular Atrophy, Spinal drug therapy, Myasthenia Gravis drug therapy, Spinal Curvatures drug therapy, Syndrome, Muscular Atrophy, Spinal complications, Myasthenia Gravis physiopathology, Posture physiology, Spinal Curvatures complications
- Published
- 2015
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13. Treatment of camptocormia with botulinum toxin.
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Bertram KL, Stirpe P, and Colosimo C
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- Humans, Muscular Atrophy, Spinal etiology, Muscular Atrophy, Spinal physiopathology, Parkinson Disease complications, Spinal Curvatures etiology, Spinal Curvatures physiopathology, Botulinum Toxins therapeutic use, Muscular Atrophy, Spinal drug therapy, Spinal Curvatures drug therapy
- Abstract
Camptocormia is defined as an involuntary axial postural distortion of >45° flexion which occurs in the upright position, increases whilst walking and resolves when supine (Ashour and Jankovic, 2006). Unlike orthopaedic or age related kyphosis it is not a fixed structural deformity and produces kyphosis at predominantly lumbar and thoracic rather than cervical regions. Camptocormia has been reported due to a wide range of neurologic, psychiatric, muscular and orthopaedic conditions as well as rare reports of its emergence following the initiation of a number of medications (Finsterer and Strobl, 2010). Parkinson's disease (PD) includes prominent motor features of bradykinesia, rigidity and reduced postural balance responses in all those affected with this disease, but can also cause a range of other motor and non-motor features. Camptocormia is reported in a minority of patients with PD, and it is usually associated with longer disease duration and greater disease burden (Tiple et al., 2009). The aetiology of camptocormia in PD is debated, and responses to treatment have been generally poor and variable between studies. Recent studies have suggested the use of botulinum toxin may improve posture in some affected individuals., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
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- 2015
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14. Treatment of camptocormia with continuous subcutaneous infusions of apomorphine: 1-year prospective pilot study.
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Mensikova K, Kaiserova M, Vastik M, Kurcova S, and Kanovsky P
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- Aged, Female, Humans, Injections, Subcutaneous, Male, Middle Aged, Muscular Atrophy, Spinal physiopathology, Parkinson Disease drug therapy, Parkinson Disease physiopathology, Pilot Projects, Prospective Studies, Spinal Curvatures physiopathology, Treatment Outcome, Apomorphine administration & dosage, Dopamine Agonists administration & dosage, Muscular Atrophy, Spinal drug therapy, Spinal Curvatures drug therapy
- Abstract
Camptocormia is defined as a marked dystonic flexion of the trunk in the sagittal plane. Camptocormia responds poorly to botulinum toxin injections, manipulation with dopaminergic treatment, and deep brain stimulation. We designed a prospective pilot study to assess the effect of apomorphine infusions on camptocormia. Five patients were enrolled. All five patients responded well to this treatment. The fact that camptocormia responds so well to apomorphine may be explained by the sustained stimulation of the ventrolateral striatal D1 receptors, alleviating this type of dystonia.
- Published
- 2015
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15. Improvement in dystonic camptocormia following botulinum toxin injection to the external oblique muscle.
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Wijemanne S and Jimenez-Shahed J
- Subjects
- Female, Humans, Male, Abdominal Muscles drug effects, Anesthetics, Local administration & dosage, Lidocaine administration & dosage, Muscular Atrophy, Spinal drug therapy, Parkinson Disease complications, Spinal Curvatures drug therapy
- Published
- 2014
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16. Unusual case of levodopa-responsive camptocormia in a patient with negative dopamine transporter scan and normal DYT 5 gene.
- Author
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Oravivattanakul S, Abboud H, Fernandez H, and Itin I
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- Apoptosis Regulatory Proteins genetics, Corpus Striatum metabolism, DNA-Binding Proteins genetics, Humans, Male, Middle Aged, Muscular Atrophy, Spinal genetics, Mutation, Nuclear Proteins genetics, Spinal Curvatures genetics, Tyrosine 3-Monooxygenase genetics, Dopamine Plasma Membrane Transport Proteins metabolism, Dystonic Disorders genetics, GTP Cyclohydrolase genetics, Levodopa therapeutic use, Muscular Atrophy, Spinal drug therapy, Spinal Curvatures drug therapy
- Abstract
Objective: To describe an unusual case of camptocormia responding to levodopa., Methods: We present a case of camptocormia with a sustained excellent response to levodopa in a patient with negative dopamine transporter and no DYT 5 genetic mutations., Results: We present a 52-year-old man with 2 years' history of progressive camptocormia, with nearly normal posture while standing and forward trunk flexion close to 90 degrees after walking for less than a minute. His posture completely resolved in the supine position. There were no pyramidal or extrapyramidal signs or dystonia in other locations. Family history was noncontributory except 1 paternal aunt with Parkinson disease. There was no history of antidopaminergic exposure. Workup, including brain, cervical, thoracic, and lumbar spine magnetic resonance imaging and paraspinal muscle electromyography, was unremarkable. Serum ceruloplasmin level was normal. Genetic testing for dopa-responsive dystonia, including GTP cyclohydrolase 1 (GCH 1) and tyrosine hydroxylase (TH) gene mutations (sequencing and deletion), was negative. DYT 6 (THAP1) gene mutation was not found, and dopamine transporter scan imaging obtained 4 years after onset of symptoms was normal. The patient has had an excellent response to levodopa sustained for the past 2 years., Conclusions: Levodopa should be considered in camptocormia even when not associated with neurodegenerative parkinsonism or DYT 5 gene mutation.
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- 2014
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17. Long-term effect of repeated lidocaine injections into the external oblique for upper camptocormia in Parkinson's disease.
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Furusawa Y, Mukai Y, Kawazoe T, Sano T, Nakamura H, Sakamoto C, Iwata Y, Wakita M, Nakata Y, Kamiya K, Kobayashi Y, Sakamoto T, Takiyama Y, and Murata M
- Subjects
- Aged, Female, Humans, Male, Muscular Atrophy, Spinal etiology, Muscular Atrophy, Spinal rehabilitation, Parkinson Disease rehabilitation, Spinal Curvatures etiology, Spinal Curvatures rehabilitation, Time, Abdominal Muscles drug effects, Anesthetics, Local administration & dosage, Lidocaine administration & dosage, Muscular Atrophy, Spinal drug therapy, Parkinson Disease complications, Spinal Curvatures drug therapy
- Abstract
Background: Parkinson's disease (PD) is occasionally complicated by camptocormia. In a previous study, we classified camptocormia into upper and lower types based on the inflection point, and reported that lidocaine injection into the external oblique muscle, but not into the internal oblique or rectus abdomen, improved upper camptocormia in PD. The effect of a single lidocaine injection disappeared over a period of few days. In this study, we used repeated lidocaine injections into the external oblique for 4-5 days and evaluated the effects of such treatment for up to 90 days., Methods: The study subjects were 12 patients with PD and upper camptocormia who were treated with repeated lidocaine injections into the bilateral external oblique followed by rehabilitation. The effect of treatment was evaluated by measuring the angle of truncal flexion before and after the injection. Patients who showed improvement with repeated injections were evaluated during a 90-day period., Results: Eight out of 12 patients showed significant improvement in posture after a single lidocaine injection. However, the effect subsided several days after treatment. Repeated injections produced long-term improvement in 9 out of 12 patients, which was maintained during the 90-day observation period in eight of these patients., Conclusions: Our results showed that repeated lidocaine injections into the external oblique improved upper camptocormia, and that the effect was maintained in the majority of patients during the 90-day observation period, indicating that repeated lidocaine injections into the external oblique have therapeutic effect on upper camptocormia in patients with Parkinson's disease., (Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2013
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18. [Camptocormia in patients with Parkinson's disease].
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Orekhova OA, Fedorova NV, and Gamaleia AA
- Subjects
- Aged, Aged, 80 and over, Anti-Dyskinesia Agents therapeutic use, Female, Follow-Up Studies, Humans, Male, Middle Aged, Muscular Atrophy, Spinal drug therapy, Muscular Atrophy, Spinal physiopathology, Parkinson Disease drug therapy, Parkinson Disease physiopathology, Prognosis, Quality of Life, Spinal Curvatures drug therapy, Spinal Curvatures physiopathology, Antiparkinson Agents therapeutic use, Botulinum Toxins therapeutic use, Muscular Atrophy, Spinal etiology, Parkinson Disease complications, Posture, Spinal Curvatures etiology, Walking physiology
- Abstract
Parkinson's disease (PD) is the most frequent among a broad spectrum of neurologic etiologies of саmptocormia. Camptocormia (CC) is characterized by an abnormal posture with involuntary forward flexion of the trunk, which appears in erect position, increases during prolonged standing or walking, and abates in supine position. CC leads to malposition, increasing postural instability and risk of falling. Treatment of CC in PD includes adjustment of antiparkinsonian medication, injections of botulinum toxin and orthopedical interventions. In this study, CC occurred in sitting position in 62.9% patients and in vertical position in 30% patients, however it disappeared in all patients in a dorsal position. CC was observed throughout the day in 77.1% patients. In 78.6% of PD patients with CC, the pose changed and encouraged with the various factors including weariness and stress; 37.1% patients used a walking stick; 5.7% used a walking aid. CC was accompanied with the painful syndrome in the majority of patients (88.6%). Moreover, 66% of patients had a history of vertebrogenic disorders. The association between CC and the start of dopaminergic treatment was found in 25.7% of patients.
- Published
- 2013
19. Role of the external oblique muscle in upper camptocormia for patients with Parkinson's disease.
- Author
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Furusawa Y, Mukai Y, Kobayashi Y, Sakamoto T, and Murata M
- Subjects
- Abdominal Muscles drug effects, Aged, Anesthetics, Local pharmacology, Anesthetics, Local therapeutic use, Female, Humans, Lidocaine pharmacology, Lidocaine therapeutic use, Male, Middle Aged, Muscular Atrophy, Spinal drug therapy, Muscular Atrophy, Spinal physiopathology, Parkinson Disease physiopathology, Spinal Curvatures drug therapy, Spinal Curvatures physiopathology, Abdominal Muscles physiopathology, Muscular Atrophy, Spinal complications, Parkinson Disease complications, Spinal Curvatures complications
- Published
- 2012
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20. Myasthenia gravis can cause camptocormia.
- Author
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Kataoka H, Kiriyama T, and Ueno S
- Subjects
- Aged, Cholinesterase Inhibitors therapeutic use, Edrophonium therapeutic use, Electromyography, Female, Humans, Muscular Atrophy, Spinal diagnosis, Myasthenia Gravis diagnosis, Prednisolone therapeutic use, Remission Induction, Spinal Curvatures diagnosis, Muscular Atrophy, Spinal drug therapy, Muscular Atrophy, Spinal etiology, Myasthenia Gravis complications, Myasthenia Gravis drug therapy, Spinal Curvatures drug therapy, Spinal Curvatures etiology
- Published
- 2012
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21. Coexistence of chronic inflammatory demyelinating polyneuropathy and camptocormia.
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Terashima M, Kataoka H, Sugie K, Horikawa H, and Ueno S
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- Aged, Humans, Immunoglobulins, Intravenous therapeutic use, Immunologic Factors therapeutic use, Male, Spinal Curvatures drug therapy, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating complications, Spinal Curvatures complications
- Published
- 2009
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22. Goal attainment after treatment of parkinsonian camptocormia with botulinum toxin.
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Fietzek UM, Schroeteler FE, and Ceballos-Baumann AO
- Subjects
- Aged, Botulinum Toxins, Type A, Disability Evaluation, Female, Humans, Male, Parkinsonian Disorders complications, Spinal Curvatures etiology, Treatment Outcome, Botulinum Toxins therapeutic use, Neuromuscular Agents therapeutic use, Spinal Curvatures drug therapy
- Published
- 2009
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23. Amelioration of subacute camptocormia in multiple system atrophy by protirelin tartrate.
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Takei A, Hamada S, Homma S, Hamada K, Tashiro K, and Hamada T
- Subjects
- Aged, Female, Humans, Multiple System Atrophy drug therapy, Hormones administration & dosage, Multiple System Atrophy complications, Spinal Curvatures drug therapy, Spinal Curvatures etiology, Thyrotropin-Releasing Hormone administration & dosage
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- 2009
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24. [Bent spine straightens up--a case of camptocormia].
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Mahjneh I, Edström B, and Sandström G
- Subjects
- Dystonic Disorders complications, Female, Humans, Spinal Curvatures etiology, Botulinum Toxins, Type A therapeutic use, Dystonic Disorders drug therapy, Neuromuscular Agents therapeutic use, Spinal Curvatures drug therapy
- Abstract
Bent spine, i.e. camptocormia appears in several disease. Segmental dystonia is one of these. A few cases benefiting from botulinum toxin therapy have been described in the literature. We describe a case, in which segmental dystonia is associated with camptocormia, causing the patient to use a wheelchair. The condition fulfilled the criteria of both clinical and electromyographic dystonia. Administration of botulinum toxin into rectus abdominus muscles was started. The response was good: the patient was able to walk in a fairly erect posture assisted by a rolling walker.
- Published
- 2009
25. Multiple fish vertebra deformity in child with systemic lupus erythematosus: a case report.
- Author
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Ozaki D, Shirai Y, Nakayama Y, Yoshihara K, and Huzita T
- Subjects
- Anti-Inflammatory Agents adverse effects, Bone Density, Bone Diseases, Metabolic drug therapy, Calcitonin analogs & derivatives, Calcitonin therapeutic use, Child, Female, Humans, Hydroxycholecalciferols therapeutic use, Low Back Pain drug therapy, Low Back Pain etiology, Methylprednisolone adverse effects, Prednisolone adverse effects, Spinal Curvatures drug therapy, Bone Diseases, Metabolic etiology, Lupus Erythematosus, Systemic complications, Spinal Curvatures etiology
- Abstract
We report an 11-year-old female patient with multiple fish vertebra deformity, which occurred in the course of treatment with corticosteroids for systemic lupus erythematosus (SLE). She was treated for SLE with predonisolone (30 mg per day) from April 2, 1996, and presented at our outpatient clinic for an osteoporosis check-up on April 27. She was 132 cm tall with-1.7 standard deviation of the average height, and X-ray examination revealed no evidence of osteoporosis in the spine. Bone mineral density (BMD) was 74.7% of the average BMD. Subsequently, she grew to 136 cm in September. However she began to have low back pain (LBP) from November, and received alfacalcidol. LBP deteriorated after pulse therapy with methylpredonisolone. In June 1997, X-ray examination revealed multiple fish vertebra deformity with 58.3% of the average BMD. Moreover her height had decreased to 131cm. She underwent combination therapy with elcatonin and alfacalcidol. In September 1999, she had no LBP nor progression of fish vertebra deformity. However she had no growth in height. Corticoseroids and SLE have multiple effects on bone metabolism, making the treatment of porosis complicated and difficult.
- Published
- 2000
- Full Text
- View/download PDF
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