94 results on '"Spinazzola, J."'
Search Results
2. DMD – ANIMAL MODELS
- Author
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Lambert, M., primary, Zhang, Y., additional, Spinazzola, J., additional, Widrick, J., additional, Conner, J., additional, and Kunkel, L., additional
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- 2021
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3. PRE-CLINICAL DEVELOPMENTS IN NEUROMUSCULAR DISORDERS
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Zhang, Y., primary, Lambert, M., additional, Widrick, J., additional, Conner, J., additional, Spinazzola, J., additional, and Kunkel, L., additional
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- 2021
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4. DMD – ANIMAL MODELS: EP.95 Downregulation of the genetic modifier PITPNA as means of therapy in Duchenne muscular dystrophy
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Lambert, M., Zhang, Y., Spinazzola, J., Widrick, J., Conner, J., and Kunkel, L.
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- 2021
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5. Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A
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Alexander, M S, primary, Gasperini, M J, additional, Tsai, P T, additional, Gibbs, D E, additional, Spinazzola, J M, additional, Marshall, J L, additional, Feyder, M J, additional, Pletcher, M T, additional, Chekler, E L P, additional, Morris, C A, additional, Sahin, M, additional, Harms, J F, additional, Schmidt, C J, additional, Kleiman, R J, additional, and Kunkel, L M, additional
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- 2016
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6. Absence of γ-sarcoglycan alters the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle
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Moorwood, C. Philippou, A. Spinazzola, J. Keyser, B. Macarak, E.J. Barton, E.R.
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musculoskeletal system - Abstract
Background: The dystrophin glycoprotein complex (DGC) is located at the sarcolemma of muscle fibers, providing structural integrity. Mutations in and loss of DGC proteins cause a spectrum of muscular dystrophies. When only the sarcoglycan subcomplex is absent, muscles display severe myofiber degeneration, but little susceptibility to contractile damage, suggesting that disease occurs not by structural deficits but through aberrant signaling, namely, loss of normal mechanotransduction signaling through the sarcoglycan complex. We extended our previous studies on mechanosensitive, γ-sarcoglycan-dependent ERK1/2 phosphorylation, to determine whether additional pathways are altered with the loss of γ-sarcoglycan.Methods: We examined mechanotransduction in the presence and absence of γ-sarcoglycan, using C2C12 myotubes, and primary cultures and isolated muscles from C57Bl/6 (C57) and γ-sarcoglycan-null (γ-SG-/-) mice. All were subjected to cyclic passive stretch. Signaling protein phosphorylation was determined by immunoblotting of lysates from stretched and non-stretched samples. Calcium dependence was assessed by maintaining muscles in calcium-free or tetracaine-supplemented Ringer's solution. Dependence on mTOR was determined by stretching isolated muscles in the presence or absence of rapamycin.Results: C2C12 myotube stretch caused a robust increase in P-p70S6K, but decreased P-FAK and P-ERK2. Neither Akt nor ERK1 were responsive to passive stretch. Similar but non-significant trends were observed in C57 primary cultures in response to stretch, and γ-SG-/- cultures displayed no p70S6K response. In contrast, in isolated muscles, p70S6K was mechanically responsive. Basal p70S6K activation was elevated in muscles of γ-SG-/- mice, in a calcium-independent manner. p70S6K activation increased with stretch in both C57 and γ-SG-/- isolated muscles, and was sustained in γ-SG-/- muscles, unlike the transient response in C57 muscles. Rapamycin treatment blocked all of p70S6K activation in stretched C57 muscles, and reduced downstream S6RP phosphorylation. However, even though rapamycin treatment decreased p70S6K activation in stretched γ-SG-/- muscles, S6RP phosphorylation remained elevated.Conclusions: p70S6K is an important component of γ-sarcoglycan-dependent mechanotransduction in skeletal muscle. Our results suggest that loss of γ-sarcoglycan uncouples the response of p70S6K to stretch and implies that γ-sarcoglycan is important for inactivation of this pathway. Overall, we assert that altered load-sensing mechanisms exist in muscular dystrophies where the sarcoglycans are absent. © 2014 Moorwood et al.; licensee BioMed Central Ltd.
- Published
- 2014
7. Negative pressure wound therapy with Bio-Dome dressing technology in the treatment of complex wounds: A case series
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Penny, H.L., primary, Spinazzola, J., additional, Green, A., additional, Rifkah, M., additional, Faretta, M., additional, Youshaw, D., additional, Weaver, A., additional, and Zaki, P., additional
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- 2014
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8. Selective case study describing the use of Apligraf on necrobiosis lipoidica associated with diabetes
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Penny, H.L., primary, Faretta, M., additional, Rifkah, M., additional, Weaver, A., additional, Swires, A., additional, and Spinazzola, J., additional
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- 2014
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9. Determination of dextromoramide in plasma and whole blood using high-performance liquid chromatography with ultraviolet absorbance detection
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Rop, Pok Phak, primary, Grimaldi, F., additional, Bresson, M., additional, Spinazzola, J., additional, Quicke, J., additional, and Viala, A., additional
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- 1992
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10. APWCA clinical rounds. The use of negative-pressure wound therapy with bio-dome dressing technology in the treatment of complex diabetic wounds.
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Penny HL, Dyson M, Spinazzola J, Green A, Faretta M, and Meloy G
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- 2010
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11. APWCA clinical rounds. The use of acticoat moisture control for the successful treatment of diabetic ulcers.
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Penny HL, Webster N, Sullivan R, Spinazzola J, Green A, and Faretta M
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- 2009
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12. APWCA clinical rounds. A multidisciplinary approach to a possible limb-threatening infection.
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Penny HL, Webster N, Sullivan R, and Spinazzola J
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- 2008
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13. Resiliency factors in the relation between childhood sexual abuse and adulthood sexual assault in college-age women.
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Walsh K, Blaustein M, Knight WG, Spinazzola J, and van der Kolk BA
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Research has suggested that childhood sexual abuse (CSA) may be a risk factor for adulthood sexual assault. This study examined associations between CSA experiences, cognitive resiliency variables, and revictimization. Participants were 73 college-age females who completed self-report questionnaires assessing CSA, adult assault, self-efficacy, locus of control (LOC), and coping styles. Sexual assault was categorized as forced or coerced assault based on the tactics used by the perpetrator. Results indicated that CSA alone was the strongest independent predictor of forced adult assault; however, LOC and positive coping were associated with resiliency to coercive sexual assault. The current findings have clinical implications in that LOC and coping styles are characteristics that can be enhanced through therapy. [ABSTRACT FROM AUTHOR]
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- 2007
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14. Evaluation of a theater-based youth violence prevention program for elementary school children.
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Kisiel C, Blaustein M, Spinazzola J, Schmidt CS, Zucker M, and van der Kolk B
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The present study evaluated the impact of Urban Improv (UI), a theater-based youth violence prevention (YVP) program developed for inner-city youth, on three behavioral and psychological outcome domains: aggressive behaviors, prosocial behaviors, and scholastic attention and engagement. This study compared outcomes for 77 elementary school students in classrooms designated to receive UI with those of 63 students from matched control classrooms. Findings revealed that students who received UI were superior to matched controls on all outcome domains. Findings support UI as a promising practice for YVP with urban elementary school students and suggest that greater attention should be focused on application of theater-based programs in YVP. [ABSTRACT FROM AUTHOR]
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- 2006
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15. Determination of amineptine and its main metabolite in plasma by high-performance liquid chromatography after solid-phase extraction
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Phak Rop, Pok, primary, Spinazzola, J., additional, Bresson, M., additional, Conquy, T., additional, and Viala, A., additional
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- 1990
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16. Quantitation and Ultraviolet Spectrum Identification of Buflomedil in Whole Blood and Plasma by HPLC
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Rop, Pok Phak, primary, Bresson, M., additional, Antoine, J., additional, Spinazzola, J., additional, Fornaris, M., additional, and Viala, A., additional
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- 1990
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17. T.P.4.04 Automated drug screening with contractile muscle tissue engineered from dystrophic myoblasts
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Vandenburgh, H., Shansky, J., Benesch-Lee, F., Skelly, K., Spinazzola, J., Saponjian, Y., and B.S. Tseng
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- 2009
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18. Column liquid chromatographic analysis of barbiturates in biological fluids
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Rop, Pok Phak, primary, Spinazzola, J., additional, Zahra, A., additional, Bresson, M., additional, Quicke, J., additional, and Viala, A., additional
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- 1988
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19. Wound management on the leading edge: case presentations from APWCA.
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Penny HL, Webster N, and Spinazzola J
- Abstract
Here are some examples of different approaches to wound care [ABSTRACT FROM AUTHOR]
- Published
- 2007
20. The relationship of posttraumatic stress disorder and developmental trauma disorder with childhood psychopathology: A network analysis.
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Knefel M, Karatzias T, Spinazzola J, Shevlin M, and Ford JD
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- Adolescent, Humans, Child, Female, Male, Comorbidity, Psychopathology, Life Change Events, Risk Factors, Stress Disorders, Post-Traumatic diagnosis, Stress Disorders, Post-Traumatic epidemiology, Stress Disorders, Post-Traumatic psychology
- Abstract
Objective: Potentially traumatic experiences are a major risk factor for mental disorders in children and adolescents. Posttraumatic psychopathology includes trauma-specific disorders such as posttraumatic stress disorder (PTSD) as well as other psychiatric disorders. Developmental Trauma Disorder (DTD) has been proposed as a developmentally sensitive diagnosis. We aimed to further illuminate the co-occurrence of psychiatric conditions with DTD and PTSD., Method: In a convenience sample of families of 507 children and adolescents (mean age = 12.11 years old, SD = 2.92; 48.5% female), we assessed DTD, PTSD, and screened for psychiatric disorders. We estimated network models including DTD, PTSD and ten psychiatric conditions., Results: We found that DTD and PTSD share both common and differential comorbidity features on disorder-, domain-, and symptom-level. The differential comorbidity patterns of the DTD and PTSD domains placed DTD close to both externalizing and internalizing psychopathology while PTSD was primarily linked to internalizing conditions., Conclusions: Our study provides evidence for the complex clinical presentation of posttraumatic psychopathology over and above PTSD in children. DTD and PTSD provide useful and distinct diagnostic categories for children who are also experiencing internalizing conditions, and DTD may be especially relevant for children who are experiencing externalizing psychopathology., Competing Interests: Declaration of Competing Interest All authors declare that they have no conflict of interest., (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2023
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21. Can developmental trauma disorder be distinguished from posttraumatic stress disorder? A symptom-level person-centred empirical approach.
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Ford JD, Charak R, Karatzias T, Shevlin M, and Spinazzola J
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- Child, Humans, Female, Adolescent, Male, Comorbidity, Mental Health, Stress Disorders, Post-Traumatic diagnosis
- Abstract
Background: Developmental Trauma Disorder (DTD) is a proposed childhood psychiatric diagnosis for psychopathological and developmental sequela of victimization and attachment trauma extending beyond posttraumatic stress disorder (PTSD)., Objective: To determine whether a sub-group of trauma-impacted children is characterized by symptoms of DTD that extend beyond, or co-occur with, the symptoms of PTSD., Method: Person-centred Latent Class Analyses (LCA) were done with data from 507 children (ages 7-18 years, ( M = 12.11, SD = 2/92); 49% female) referred to the study by mental health or paediatric clinicians., Results: A four class solution was optimal (LMR = 398.264, p < .001; Entropy = .93): (1) combined DTD + PTSD ( n = 150); (2) predominant DTD ( n = 156); (3) predominant PTSD ( n = 54); (4) minimal symptoms ( n = 147). Consistent with prior research, the DTD + PTSD class was most likely to have experienced traumatic emotional abuse and neglect ( X
2 (3) = 16.916 and 28.016, respectively, p < .001), and had the most psychiatric comorbidity ( F (3, 502) = 3.204, p < .05). Predominant DTD class members were most likely to meet criteria for Oppositional Defiant Disorder (ODD) ( X2 (3) = 84.66, p < .001)., Conclusion: Symptoms of DTD may occur with, or separately from, PTSD symptoms. Children with high DTD|+PTSD symptoms had extensive psychiatric comorbidity, while those with high DTD symptoms and minimal PTSD symptoms were highly likely to meet criteria for ODD. In clinical and research assessment and treatment of children with complex psychiatric comorbidity or disruptive behaviour problems, symptoms of DTD should be considered, both along with, and in the absence of, PTSD symptoms., Competing Interests: Julian Ford was a consultant to Advanced Trauma Solutions Professionals Inc. (the licensed distributor of the TARGET© intervention copyrighted by the University of Connecticut) in the past 2 years. No other author reports any conflict of interest., (© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)- Published
- 2022
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22. The Latent Structure of Child and Adolescent Psychopathology and its Association with Different Forms of Trauma and Suicidality and Self-Harm : LATENT STRUCTURE OF PSYCHOPATHOLOGY.
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Hyland P, Karatzias T, Ford JD, Fox R, and Spinazzola J
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- Child, Humans, Adolescent, Psychopathology, Suicidal Ideation, Suicide, Self-Injurious Behavior epidemiology, Mental Disorders epidemiology
- Abstract
The Hierarchical Taxonomy of Psychopathology (HiTOP) is a multidimensional and hierarchical model of the latent structure of psychopathology. While HiTOP has received much support in child/adolescent community samples, fewer studies have assessed this model in clinical samples of children/adolescents. Here, we modelled the latent structure of 45 symptoms of psychopathology from a clinical sample of children/adolescents and assessed how dimensions of psychopathology were related to specific forms of trauma and suicidality/self-harm. Clinician-derived assessments were obtained from 507 people aged 7-18 years. Confirmatory factor analysis was used to determine the optimal fitting model, and structural equation modelling was used to estimate associations with trauma exposure and suicidality/self-harm. The best fitting model(s) included five first-order factors reflecting Fear, Distress, Externalizing, Thought Disorder, and Traumatic Stress, with a higher-order general factor (p) accounting for the covariation between these factors. Unique associations were identified between specific forms of trauma and each dimension of psychopathology. p was strongly associated with suicidality/self-harm, and of the first-order factors, Distress was most strongly associated with suicidality/self-harm. Findings support the predictions of HiTOP that the latent structure of child/adolescent psychopathology can be effectively described by a multidimensional and hierarchal model. Moreover, we found tentative evidence for a unique dimension of Traumatic Stress psychopathology. Our findings also highlight the unique associations between specific forms of early life trauma and specific dimensions of psychopathology, and the importance of Distress related psychopathology for suicidality/self-harm in children and adolescents., (© 2022. The Author(s).)
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- 2022
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23. Beyond PTSD: Client presentations of developmental trauma disorder from a national survey of clinicians.
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DePierro J, D'Andrea W, Spinazzola J, Stafford E, van Der Kolk B, Saxe G, Stolbach B, McKernan S, and Ford JD
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- Adolescent, Adult, Child, Child, Preschool, Comorbidity, Data Collection, Diagnostic and Statistical Manual of Mental Disorders, Humans, Young Adult, Stress Disorders, Post-Traumatic diagnosis, Stress Disorders, Post-Traumatic epidemiology, Stress Disorders, Post-Traumatic psychology
- Abstract
Objective: The emergence of updated Diagnostic and Statistical Manual of Mental Disorders (5th ed. [DSM-5]; American Psychiatric Association, 2013) criteria for posttraumatic stress disorder (PTSD), which includes modified criteria for young children, raises questions regarding the need for developmentally appropriate standalone psychiatric diagnosis encompassing complex trauma presentations in children. The present study addresses these questions by examining how DSM-5 PTSD and proposed developmental trauma disorder (DTD) diagnoses relate to functional impairment and trauma exposure using clinician-report surveys., Method: We surveyed psychotherapists across the United States, and asked them to report on the symptom characteristics, functional impairment, and trauma exposure of children, adolescents, and young adults under their care ( n = 210; age range = 2-21). We fit symptom data to the draft criteria for (1) DTD, a proposed trauma diagnosis for children and (2) existing criteria for adult and child/preschool PTSD., Results: Results indicated that comorbidity between DTD and PTSD was high (52.4% and 59.9% for adult and child/preschool criteria, respectively). Comorbid DTD/PTSD and DTD-alone groups had more functional domains impacted and greater exposure to some types of trauma relative to the other groups., Conclusions: These findings speak to the relationship between trauma complexity and wide-ranging symptom presentations, provide support for research and clinical emphasis on a developmentally informed diagnosis, and may support existing treatment approaches. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
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- 2022
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24. Development of a Differential Assessment Guide to Improve Engagement with Youths & Families Living with Chronic Trauma.
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Kagan R, Pressley J, Espinoza R, Lanktree C, Henry J, Knoverek A, Duffy S, Labruna V, Habib M, Blaustein ME, and Spinazzola J
- Abstract
Youths and parents/caregivers who have experienced multiple forms of severe interpersonal trauma may demonstrate severe and persistent symptoms of complex trauma including high-risk behaviors. Engagement, and sustaining engagement, of these youths and parents/caregivers in evidence-supported trauma treatment is a critical challenge, especially when youths or parents/caregivers have experienced chronic traumas that may be expected to continue into the foreseeable future. An extensive literature review was conducted leading to development of an assessment framework that could increase engagement of youths and parents/caregivers in trauma treatment based on research on chronic trauma, complex trauma, Developmental Trauma Disorder (DTD), and factors that promote engagement. A multi-dimensional assessment guide was developed to enable clinicians to differentiate types of chronic trauma based on a continuum of past, current and expected exposure over time and then to use this guide collaboratively with youths and parents/caregivers to develop priorities for treatment and service planning that matches their needs and strengths. The assessment guide incorporates exposure to intra-familial and community forms of interpersonal trauma, attachment disruptions, established symptoms of PTSD, Complex PTSD and DTD, as well as social-emotional development. The assessment and treatment planning guides proposed in this article expand applicability of evidence-supported trauma-informed therapy to youths and families who have not been engaged by programs offering treatments that are focused on past or single incident traumas or do not address disrupted attachments, multi-generational experiences of adversity, discrimination and community violence, life-threatening dangers or the impact of chronic trauma on youth, parent/caregiver and family development., Competing Interests: Conflict of Interest StatementOn behalf of all authors, the corresponding author states that there is no conflict of interest., (© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
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- 2022
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25. Can Developmental Trauma disorder be distinguished from posttraumatic stress disorder? A confirmatory factor Analytic Test of Four Structural Models.
- Author
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Ford JD, Shevlin M, Karatzias T, Charak R, and Spinazzola J
- Subjects
- Adult, Arousal, Child, Factor Analysis, Statistical, Humans, Syndrome, Domestic Violence, Stress Disorders, Post-Traumatic diagnosis
- Abstract
Developmental Trauma Disorder (DTD) is a proposed child psychopathology diagnosis with emotion/somatic, attention/behavioral, and self/relational dysregulation symptoms extending beyond posttraumatic stress disorder (PTSD). Confirmatory factor analyses (CFAs) tested four structural models with structured interview data for trauma history, PTSD, and DTD with 507 children receiving mental health or pediatric care ( N = 162, 32% diagnosed with DTD; N = 176; 35% with PTSD; N = 169, 33% with neither). A unidimensional model with a single latent variable had unacceptable fit (RMSEA = 0.094; CFI = 0.844). Compared to a model with PTSD and DTD as correlated first-order latent variables, a multidimensional model with correlated latent variables corresponding to the PTSD and DTD symptom clusters (Dc
2 =105.62, Ddf = 14, p < .001) and a hierarchical variant with correlated second order DTD and PTSD latent variables (Dc2 =48.10, Ddf = 6, p < .001) fit the data better. The non-hierarchical multidimensional model was superior to the hierarchical variant (Dc2 =66.05, Ddf = 8, p < .001). Stronger latent variable inter-correlations within PTSD and DTD domains than across domains, suggested that DTD and PTSD are distinguishable despite their inter-correlation. Exposure to family violence was the primary correlate of both the DTD and PTSD second-order latent variables. Results indicate that children's trauma-related symptoms involve six inter-correlated domains extend beyond PTSD's symptoms (i.e., re-experiencing, avoidance, arousal) to include DTD symptoms of emotional, cognitive-behavioral, and self-relational dysregulation. The inter-relationship of the DTD and PTSD latent variables suggest that DTD may constitute a component within a complex PTSD diagnosis paralleling the new adult CPTSD diagnosis., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)- Published
- 2022
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26. Toward an empirically based Developmental Trauma Disorder diagnosis and semi-structured interview for children: The DTD field trial replication.
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Ford JD, Spinazzola J, van der Kolk B, and Chan G
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- Adolescent, Child, Diagnostic and Statistical Manual of Mental Disorders, Disease Progression, Female, Humans, Male, Psychometrics, Psychotherapy, Quality of Life, Reproducibility of Results, Mental Disorders diagnosis, Stress Disorders, Post-Traumatic diagnosis, Stress Disorders, Post-Traumatic psychology
- Abstract
Objective: Developmental trauma disorder (DTD) is a childhood psychiatric syndrome designed to include sequelae of trauma exposure not fully captured by PTSD. This study aimed to determine whether the assessment of DTD with an independent sample of children in mental health treatment will replicate results from an initial validation study., Methods: The DTD semi-structured interview (DTD-SI) was administered to a convenience sample in six sites in the United States (N = 271 children in mental health care, 8-18 years old, 47% female, 41% Black or Latinx) with measures of trauma history, DSM-IV PTSD, probable DSM-IV psychiatric diagnoses, emotion regulation/dysregulation, internalizing/externalizing problems, and quality of life. Confirmatory factor (CFA) and item response theory (IRT) analyses tested DTD's structure and DTD-SI's information value. Bivariate and multivariate analyses tested DTD's criterion and convergent validity., Results: A three-factor solution (i.e., emotion/somatic, attentional/behavioral, and self/relational dysregulation) best fit the data (CFI = 0.91; TLI = 0.89; BIC = 357.17; RMSEA = 0.06; SRMR = 0.05). DTD-SI items were informative across race/ethnicity, gender, and age with three exceptions. Emotion dysregulation was the most informative item at low levels of DTD severity. Non-suicidal self-injury was rare but discriminative in identifying children with high levels of DTD severity. Results supported the criterion and convergent validity of the DTD construct., Conclusion: This replication provides empirical support for DTD as a construct and potential psychiatric syndrome, and the DTD-SI's validity as a clinical research tool., (© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2022
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27. Developmental Trauma Disorder: A Legacy of Attachment Trauma in Victimized Children.
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Spinazzola J, van der Kolk B, and Ford JD
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- Child, Humans, Psychotherapy, Child Abuse, Crime Victims, Domestic Violence, Stress Disorders, Post-Traumatic epidemiology, Stress Disorders, Post-Traumatic etiology
- Abstract
Developmental trauma disorder (DTD) and posttraumatic stress disorder (PTSD) have been found to have both shared and unique traumatic antecedents. The present study was an independent replication, with the DTD Structured Interview and the Traumatic Events Screening Instrument administered to 271 children in mental health treatment in six U.S. sites. On an unadjusted basis, DTD (27.3% prevalence, N = 74) and PTSD (40.2% prevalence, N = 109) both were associated with traumatic physical assault or abuse, family violence, emotional abuse, caregiver separation or impairment, and polyvictimization. After controlling for PTSD, DTD was associated emotional abuse, OR = 2.9, 95% CI [1.19, 6.95], and traumatic separation from a primary caregiver, OR = 2.2, 95% CI [1.04. 4.60], both of which also were associated with caregiver impairment, physical assault/abuse, and witnessing family/community violence. Three traumatic antecedents associated with PTSD were not associated with DTD: noninterpersonal trauma, sexual trauma, and traumatic loss. Children exposed to both traumatic victimization and attachment trauma (36.2%) or attachment trauma alone (32.5%) were more likely than children exposed only to victimization (17.5%) or those with no history of victimization or attachment trauma (8.1%) to meet the symptom criteria for DTD, χ²(3, N = 271) = 17.68, p < .001. Study findings replicate and extend prior DTD field trial study results, showing that, although PTSD and DTD share traumatic antecedents, DTD is uniquely associated with traumatic emotional abuse and caregiver separation. Further research is needed to examine how specific trauma types contribute to the risk, course, and severity of DTD., (© 2021 The Authors. Journal of Traumatic Stress published by Wiley Periodicals LLC on behalf of International Society for Traumatic Stress Studies.)
- Published
- 2021
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28. Psychiatric comorbidity of developmental trauma disorder and posttraumatic Stress disorder: findings from the DTD field trial replication (DTDFT-R).
- Author
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Ford JD, Spinazzola J, and van der Kolk B
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- Adolescent, Anxiety, Separation psychology, Child, Depressive Disorder psychology, Female, Humans, Interviews as Topic, Male, Psychiatric Status Rating Scales, Comorbidity, Stress Disorders, Post-Traumatic diagnosis
- Abstract
Background : Developmental Trauma Disorder (DTD) has extensive comorbidity with internalizing and externalizing disorders distinct from posttraumatic stress disorder (PTSD). Objective : To replicate findings of DTD comorbidity and to determine whether this comorbidity is distinct from, and extends beyond, comorbidities of PTSD. Method : DTD was assessed by structured interview, and probable DSM-IV psychiatric disorders were identified with KSADS-PL screening modules, in a multi-site sample of 271 children (ages 8-18 years old; 47% female) in outpatient or residential mental health treatment for multiple ( M = 3.5 [SD = 2.4]) psychiatric diagnoses other than PTSD or DTD. Results : DTD ( N = 74, 27%) and PTSD ( N = 107, 39%) were highly comorbid and shared several DSM-IV internalizing and externalizing disorder comorbidities. Children with DTD with or without PTSD had more comorbid diagnoses ( M = 5.7 and 5.2 [SD = 2.4 and 1.7], respectively) than children with PTSD but not DTD ( M = 3.8[SD = 2.1]) or neither PTSD nor DTD ( M = 2.1[SD = 1.9]), F [3,267] = 55.49, p < .001. Further, on a multivariate basis controlling for demographics and including all potential comorbid disorders, DTD was associated with separation anxiety disorder, depression, and oppositional defiant disorder after controlling for PTSD, while PTSD was associated only with separation anxiety disorder after controlling for DTD. Both DTD and PTSD were associated with suicidality. Conclusions : DTD is associated with psychiatric comorbidity beyond that of PTSD, and DTD warrants assessment for treatment planning with children in intensive psychiatric services., Competing Interests: Bessel van der Kolk and Joseph Spinazzola report no conflicts of interest. Julian Ford is a consultant to Advanced Trauma Solutions Professionals, Inc., the sole licensed distributor of the TARGET model copyrighted by the University of Connecticut., (© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)
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- 2021
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29. The effectiveness of trauma-informed wilderness therapy with adolescents: A pilot study.
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Johnson EG, Davis EB, Johnson J, Pressley JD, Sawyer S, and Spinazzola J
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- Adaptation, Psychological, Adolescent, Complementary Therapies psychology, Family Relations psychology, Female, Humans, Male, Pilot Projects, Surveys and Questionnaires, Treatment Outcome, Complementary Therapies methods, Psychotherapy methods, Residential Treatment methods, Stress Disorders, Traumatic psychology, Stress Disorders, Traumatic therapy, Wilderness
- Abstract
Objective: Wilderness therapy (WT) is a complementary/integrative approach for treating struggling adolescents by using outdoor adventure activities to foster personal and interpersonal growth/well-being. Empirical support for the effectiveness of traditional WT is growing, but evidence supporting trauma-informed WT (TIWT) is lacking. This pilot study addresses that gap. Method: Between 2009 and 2019, 816 adolescents (Ages 13-17, M
age = 15.36, SD = 1.25; 41.1% female) completed the Youth-Outcome Questionnaire-SR 2.0 at intake and discharge ( M = 75.02 days, SD = 28.77). Three-hundred seventy-eight adolescents also completed the Family Assessment Device-General Functioning (FAD-GF), and 253 adolescents completed two, 2.5-min segments of heart-rate-variability biofeedback (one while resting and one while using a coping skill). One-hundred eighty-nine caregivers completed the Youth-Outcome Questionnaire 2.01, and 181 caregivers completed the FAD-GF. Between 25 and 99 adolescents and caregivers also completed psychological and family measures at 6 months and 1 year postdischarge. Results: Adolescents reported experiencing improvements in psychological and family functioning. They also exhibited improvement in psychophysiological functioning (heart-rhythm coherence). Caregivers reported improvements in family functioning and their child's psychological functioning. Caregivers observed more persisting benefits in their child's psychological functioning, whereas adolescents reported more persisting benefits in family functioning. Changes in psychological and family functioning were related. There were very few differential effects on the basis of demographic factors, trauma exposure, or past and current treatment factors. Conclusion: Results of this pilot study suggest TIWT is a promising complementary/integrative intervention for improving the psychological, family, and psychophysiological functioning of struggling adolescents. (PsycInfo Database Record (c) 2020 APA, all rights reserved).- Published
- 2020
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30. The impact of neurofeedback training on children with developmental trauma: A randomized controlled study.
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Rogel A, Loomis AM, Hamlin E, Hodgdon H, Spinazzola J, and van der Kolk B
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- Adolescent, Child, Female, Humans, Male, Pilot Projects, Child Abuse psychology, Child Abuse therapy, Neurofeedback methods, Stress Disorders, Post-Traumatic psychology, Stress Disorders, Post-Traumatic therapy
- Abstract
Objective: Developmental trauma or chronic early childhood exposure to abuse and neglect by caregivers has been shown to have a long-lasting pervasive impact on mental and neural development, including problems with attention, impulse control, self-regulation, and executive functioning. Its long-term effects are arguably the costliest public health challenge in the United States. Children with developmental trauma rarely have a satisfactory response to currently available evidence-based psychotherapeutic and pharmacological treatments. Neurofeedback training (NFT) is a clinical application of brain computer interface technology, aiming to alter electrical brain activity associated with various mental dysfunctions. NFT has shown promise to improve posttraumatic stress disorder (PTSD) symptoms., Method: This randomized controlled study examined the effects of NFT on 37 children, aged 6-13 years with developmental trauma. Participants were randomly divided into active NFT ( n = 20) or treatment-as-usual control ( n = 17). Both groups underwent 4 assessments during equivalent timelines. The active group received 24 NFT sessions twice a week., Results: This pilot study demonstrated that 24 sessions of NFT significantly decreased PTSD symptoms, internalizing, externalizing, other behavioral and emotional symptoms, and significantly improved the executive functioning of children aged 6-13 years with severe histories of abuse and neglect who had not significantly benefited from any previous therapy., Conclusions: NFT offers the possibility to improve learning, enhance self-efficacy, and develop better social relationships in this hitherto largely treatment-resistant population. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
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- 2020
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31. Network analysis of exposure to trauma and childhood adversities in a clinical sample of youth.
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Hodgdon HB, Suvak M, Zinoviev DY, Liebman RE, Briggs EC, and Spinazzola J
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- Adolescent, Age Factors, Child, Child, Preschool, Defense Mechanisms, Factor Analysis, Statistical, Female, Humans, Male, Child Abuse psychology, Violence psychology, Wounds and Injuries psychology
- Abstract
Categorizing and quantifying exposure to trauma and childhood adversities (CAs) presents a significant measurement and analytic challenge. The current study examined the co-occurrence of trauma and CA types using network analyses, an alternative to traditional measurement models. The Trauma History Profile, assessing lifetime exposure to 20 different trauma and CA types, was administered to 618 treatment-seeking children and youth ages 4 to 18 years (52.8% female). The generalized similarity model (Kovács, 2010) was used to construct a network of trauma/CA types to visualize relationships and detect cohesive groups. Four clusters of trauma/CA types emerged: overt forms occurring at the individual level (e.g., physical, sexual, and psychological maltreatment), environmental forms at the family level (e.g., neglect, impaired caregiving), environmental forms occurring at the community level (e.g., community and school violence), and acute forms (e.g., loss, medical trauma). Age of onset data indicated that neglect and psychological maltreatment were most predictive of later occurrences of other trauma and CAs. Structural equation modeling indicated that trauma/CA clusters displayed specific associations with posttraumatic stress, internalizing, and externalizing symptoms. Results demonstrate the potential utility of network analysis to understand the co-occurrence and temporal ordering of multiple types of trauma and CAs. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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- 2019
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32. Correction: A Randomized Controlled Study of Neurofeedback for Chronic PTSD.
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van der Kolk BA, Hodgdon H, Gapen M, Musicaro R, Suvak MK, Hamlin E, and Spinazzola J
- Abstract
[This corrects the article DOI: 10.1371/journal.pone.0166752.].
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- 2019
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33. Comorbidity of developmental trauma disorder (DTD) and post-traumatic stress disorder: findings from the DTD field trial.
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van Der Kolk B, Ford JD, and Spinazzola J
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Background : Developmental trauma disorder (DTD) has been proposed to describe the biopsychosocial sequelae of exposure to interpersonal victimization in childhood that extend beyond the symptoms of post-traumatic stress disorder (PTSD). Objective : To characterize the psychopathology comorbid with DTD and to determine whether this comorbidity is distinct from, and extends beyond, comorbidities of PTSD. Method : DTD was assessed by structured interview, and probable Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) psychiatric disorders were identified with screening modules on the Kiddie Schedule for Affective Disorders and Schizophrenia, Present/Lifetime version (K-SADS-PL), in a multi-site sample of 236 children (7-18 years old; 50% female) referred by paediatric or mental health providers. Results : DTD ( N = 80, 34%) and PTSD ( N = 69, 29%) were highly comorbid and shared several DSM-IV internalizing disorder and DSM, 5th Edition (DSM-5) dysregulation disorder comorbidities. However, DTD, but not PTSD, was associated with comorbid panic disorder and disruptive behaviour disorders. On a multivariate basis including all probable DSM-IV disorders and DSM-5 dysregulation disorders, DTD was associated with separation anxiety disorder and attention deficit hyperactivity disorder after controlling for PTSD, while PTSD was associated with major depression and generalized anxiety disorder after controlling for DTD. Conclusions : DTD's comorbidities overlap with but extend beyond those of PTSD to include panic, separation anxiety, and disruptive behaviour disorders. DTD warrants further investigation as a potential diagnosis or a complex variant of PTSD in children, similar to the adult symptoms of disturbances of self-organization in the proposed International Classification of Diseases, 11th revision (ICD-11) complex post-traumatic stress disorder subtype.
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- 2019
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34. The Complexity of Adaptation to Childhood Polyvictimization in Youth and Young Adults: Recommendations for Multidisciplinary Responders.
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Musicaro RM, Spinazzola J, Arvidson J, Swaroop SR, Goldblatt Grace L, Yarrow A, Suvak MK, and Ford JD
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- Adolescent, Black or African American, Child, Crime Victims statistics & numerical data, Exposure to Violence statistics & numerical data, Female, Hispanic or Latino, Humans, Male, Risk Factors, Sex Workers, Sexual and Gender Minorities statistics & numerical data, Stress Disorders, Post-Traumatic etiology, Urban Population, Young Adult, Adaptation, Psychological, Crime Victims psychology, Exposure to Violence psychology
- Abstract
Exposure to violence is pervasive in our society. An abundance of research has demonstrated that individuals who experience polyvictimization (PV)-prolonged or multiple forms of traumatic victimizations-are at heightened risk for continuing to experience repeated victimizations throughout their lifetimes. The current article reviews several overlapping constructs of traumatic victimizations with the ultimate goal of providing a unifying framework for conceptualizing prolonged and multiple victimization (defined in this article as PV) as a precursor to complex post-traumatic biopsychosocial adaptations, revictimization, and in some instances reenactment as a perpetrator (defined as complex trauma [CT]). This model is then applied to three socially disadvantaged victim populations-lesbian, gay, bisexual, transgender, queer, or questioning; commercially sexually exploited individuals; and urban communities of color-who are at heightened risk for PV and for exhibiting complex clinical presentations to demonstrate how the PV-CT framework can destigmatize, reframe, and ultimately reduce health disparities experienced by these populations. Trauma-informed recommendations are provided to aid researchers and multidisciplinary providers working to reduce harm and improve the quality of life for polyvictims.
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- 2019
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35. Screening for Trauma Symptoms in Child Welfare-Involved Young Children: Findings from a Statewide Trauma-Informed Care Initiative.
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Fraser JG, Noroña CR, Bartlett JD, Zhang J, Spinazzola J, Griffin JL, Montagna C, Todd M, Bodian R, and Barto B
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Young children who experience abuse, neglect, domestic violence, and other interpersonal forms of trauma are at risk for developing complex psychological trauma. Timely referrals by child welfare services for trauma evaluation and intervention is critical, particularly during the developmentally-sensitive period of birth to three. However, few screening instruments exist that are feasible for implementation in child welfare services and none have reported psychometric data for children under three. The aim of this exploratory, retrospective study was to examine developmental differences in detection rates of two brief trauma screening scales, comparing outcomes for toddlers (age 1 and 2 years) and preschoolers (age 3 to 6 years), using the evaluation data from a statewide child welfare demonstration project. The sample included 151 children ages 1 to 6 participating in evidence-based trauma treatment with their caregivers. More than 80% of children, regardless of age group, met the cut-off on one of the screeners; children who met the cut-off on either screener were significantly more likely to have experienced domestic violence, physical abuse or poly-victimization. Implications for future research are discussed., Competing Interests: Conflict of InterestThe authors declare that they have no conflicts to report., (© Springer Nature Switzerland AG 2018.)
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- 2018
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36. When Nowhere Is Safe: Interpersonal Trauma and Attachment Adversity as Antecedents of Posttraumatic Stress Disorder and Developmental Trauma Disorder.
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Spinazzola J, van der Kolk B, and Ford JD
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- Adolescent, Analysis of Variance, Child, Disease Progression, Female, Humans, Male, Psychiatric Status Rating Scales, Reactive Attachment Disorder psychology, Retrospective Studies, Stress Disorders, Post-Traumatic etiology, Adverse Childhood Experiences statistics & numerical data, Child Abuse, Sexual psychology, Domestic Violence psychology, Life Change Events, Stress Disorders, Post-Traumatic epidemiology
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Developmental trauma disorder (DTD) has been proposed as clinical framework for the sequelae of complex trauma exposure in children. In this study, we investigated whether DTD is associated with different traumatic antecedents than posttraumatic stress disorder (PTSD). In a multisite sample of 236 children referred from pediatric or mental health treatment, DTD was assessed using the DTD Structured Interview. Trauma history was assessed using the Traumatic Events Screening Instrument (TESI). On an unadjusted basis, both DTD, odds ratios (ORs) = 2.0-3.8, 95% CI [1.17, 7.19]; and PTSD, ORs = 1.8-3.0, 95% CI [1.04, 6.27], were associated with past physical assault and/or abuse, family violence, emotional abuse, neglect, and impaired caregivers; and DTD was associated community violence, OR = 2.7, 95% CI [1.35, 5.43]. On a multivariate basis after controlling for the effects of PTSD, DTD was associated with family and community violence and impaired caregivers, ORs = 2.0-2.5, 95% CI [1.09, 5.97], whereas PTSD was only associated with physical assault and/or abuse after controlling for the effects of DTD, OR = 2.4, 95% CI [1.07, 4.99]. Exposure to both interpersonal trauma and attachment adversity was associated with the highest DTD symptom count, controlling for the PTSD symptom count. Although childhood PTSD and DTD share several traumatic antecedents, DTD may be uniquely associated with pervasive exposure to violent environments and impaired caregiving. Therefore, DTD warrants further investigation as a framework for the assessment and treatment of children with histories of interpersonal victimization and attachment adversity., (© 2018 The Authors. International Society for Traumatic Stress Studies published by Wiley Periodicals, Inc. on behalf of Society for International Society for Traumatic Stress Studies.)
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- 2018
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37. Toward an Empirically Based Developmental Trauma Disorder Diagnosis for Children: Factor Structure, Item Characteristics, Reliability, and Validity of the Developmental Trauma Disorder Semi-Structured Interview.
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Ford JD, Spinazzola J, van der Kolk B, and Grasso DJ
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- Adolescent, Child, Female, Humans, Male, Psychometrics, Reproducibility of Results, Child Abuse diagnosis, Interview, Psychological, Psychiatric Status Rating Scales standards
- Abstract
Objective: Developmental trauma disorder (DTD) is an integrative syndrome for assessing the biopsychosocial sequelae of early life traumatization and attachment disruption. The psychometrics of a DTD Semi-Structured Interview (DTD-SI) and the validity and structure of the DTD construct were tested., Methods: The DTD-SI was administered by research clinicians at 5 sites between September 2011 and August 2013 to a convenience sample of 236 children ages 7-17 years (50% female, 47% black or Latino/Hispanic, 91% with trauma histories) and/or a parent, recruited in pediatric or mental health services. Validity data were obtained from structured interviews for traumatic stressor and attachment disruption history (Traumatic Events Screening Instrument), DSM-IV disorders (Kiddie Schedule for Affective Disorders and Schizophrenia, Present/Lifetime Version), and potential alternative DSM-5 disorders; parent ratings on the Child Behavior Checklist; and child self-report on measures of emotion dysregulation and quality of life., Results: Statistical analyses confirmed (a) the DTD-SI's item-level temporal and interrater reliability, informativeness, and absence (with 1 exception) of demographic bias and (b) DTD construct factor structure, unidimensionality, and convergent and discriminant validity., Conclusions: The DTD-SI yielded reliable, structurally meaningful, and valid item- and criterion-level data for the proposed DTD syndrome. Further clinical and scientific investigation of the clinical utility of DTD as a childhood psychiatric syndrome and diagnosis is warranted., (© Copyright 2018 Physicians Postgraduate Press, Inc.)
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- 2018
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38. Maltreatment type, exposure characteristics, and mental health outcomes among clinic referred trauma-exposed youth.
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Hodgdon HB, Spinazzola J, Briggs EC, Liang LJ, Steinberg AM, and Layne CM
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- Adolescent, Ambulatory Care statistics & numerical data, Ambulatory Care Facilities statistics & numerical data, Child, Child Abuse, Sexual psychology, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Mental Health, Referral and Consultation, Stress Disorders, Post-Traumatic etiology, Stress Disorders, Traumatic therapy, Young Adult, Child Abuse psychology, Physical Abuse psychology, Stress Disorders, Traumatic psychology
- Abstract
Building upon prior research documenting differential effects of psychological maltreatment, physical, and sexual abuse on youth mental health outcomes (Spinazzola et al., 2014), the present study sought to clarify the relative predictive contributions of type of maltreatment compared to salient exposure characteristics. The sample included 5058 clinic-referred youth from the Core Dataset (CDS) of the National Child Traumatic Stress Network (NCTSN) with lifetime histories of exposure to one or more of three specific types of maltreatment: psychological maltreatment (PM), physical abuse (PA), and sexual abuse (SA). First, we examined variations in salient trauma characteristics (age of onset, duration of exposure, number of co-occurring trauma types, and perpetrator type and number) by maltreatment group. Second, we examined whether type of maltreatment remained associated with mental health measures after adjusting for demographic variables and trauma characteristics. Profiles for youth with PM were more severe than youth who experienced either PA or SA only. Co-occurring PM and PA was associated with the most severe trauma exposure profile and with severity of PTSD symptoms, even after adjusting for demographic and trauma characteristics. Youth exposed to SA only had a distinct trauma profile and greater PTSD symptom severity after adjusting for demographic and trauma characteristic variables. Study findings hold important implications for trauma screening, assessment, and intervention, as well as for traumatic stress research methods that extend beyond abuse-specific or cumulative-risk approaches., (Copyright © 2018 Elsevier Ltd. All rights reserved.)
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- 2018
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39. The impact of a statewide trauma-informed child welfare initiative on children's permanency and maltreatment outcomes.
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Barto B, Bartlett JD, Von Ende A, Bodian R, Noroña CR, Griffin J, Fraser JG, Kinniburgh K, Spinazzola J, Montagna C, and Todd M
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- Child, Child Abuse psychology, Child Protective Services organization & administration, Child Welfare psychology, Child, Preschool, Delivery of Health Care organization & administration, Female, Foster Home Care psychology, Humans, Infant, Male, Massachusetts, Physical Abuse prevention & control, Physical Abuse psychology, Referral and Consultation, Stress Disorders, Traumatic prevention & control, Stress Disorders, Traumatic psychology, Child Abuse prevention & control
- Abstract
This article presents findings of a state-wide trauma informed child-welfare initiative with the goal of improving well-being, permanency and maltreatment outcomes for traumatized children. The Massachuetts Child Trauma Project (MCTP), funded by the Administration of Children and Families, Children's Bureau was a multi-year project implementing trauma-informed care into child welfare service delivery. The project's implementation design included training and consultation for mental health providers in three evidence-based treatments and training of the child-welfare workforce in trauma-informed case work practice. The learning was integrated between child-welfare and mental health with Trauma Informed Leadership Teams which included leaders from both systems and the greater community. These teams developed incremental steps toward trauma-informed system improvement. This study evaluated whether MCTP was associated with reductions in child abuse and neglect, improvements in placement stability, and higher rates of permanency during the first year of implementation. Children in the intervention group had fewer total substantiated reports of maltreatment, including less physical abuse and neglect than the comparison group by the end of the intervention year. However, children in the intervention group had more maltreatment reports (substantiated or not) and total out-of-home placements than did their counterparts in the comparison group. Assignment to MCTP, however, was not associated with an increase in kinship care or adoption. Overall, the results are promising in reinforcing the importance of mobilizing communities toward improvements in child-welfare service delivery., (Copyright © 2018 Elsevier Ltd. All rights reserved.)
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- 2018
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40. The Effects of Trauma Type and Executive Dysfunction on Symptom Expression of Polyvictimized Youth in Residential Care.
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Hodgdon HB, Liebman R, Martin L, Suvak M, Beserra K, Rosenblum W, and Spinazzola J
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- Adolescent, Anxiety etiology, Caregivers, Child, Depression etiology, Female, Humans, Male, Models, Psychological, Residential Facilities, Stress Disorders, Post-Traumatic etiology, Child Abuse psychology, Executive Function, Exposure to Violence psychology, Problem Behavior
- Abstract
Risk for traumatic sequelae is conveyed directly by risk factors (i.e., exposure to trauma), and via the disruption of developmental competencies. Exposure to caregiver trauma is an especially salient risk factor, as its early and pervasive nature is likely to undermine multiple facets of development, most notably the emergence of cognitive controls (i.e., executive function [EF]). Deficits in EF have been observed among youth exposed to multiple types of trauma and are associated with a range of functional impairments, posttraumatic stress symptoms (PTSS), and behavioral disorders; they represent a mechanism by which the negative impact of caregiver trauma is conveyed. This study included 672 youth in residential placement, and examined the associations between both caregiver and noncaregiver trauma, measured by the Trauma History Profile (THP); executive dysfunction, measured by the Behavioral Inventory of Executive Function (BRIEF); PTSS, measured by the UCLA Posttraumatic Stress Disorder (PTSD) Reaction Index (PTSD-RI); and externalizing and internalizing problems, measured by the Child Behavior Checklist (CBCL). A structural equation model demonstrated direct associations between caregiver trauma and PTSS, β = .15; noncaregiver trauma and externalizing problems, β = .14; gender and PTSS, β = .26, externalizing problems, β = .12, and internalizing problems, β = .26; and age and externalizing problems, β = -.11. We observed indirect effects via deficits in EF between caregiver trauma and PTSS, β = .04 and externalizing problems, β = .19. Results indicate for screening for executive dysfunction among trauma-impacted youth is needed, as it represents a critical therapeutic target., (Copyright © 2018 International Society for Traumatic Stress Studies.)
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- 2018
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41. Equine Facilitated Therapy for Complex Trauma (EFT-CT).
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Naste TM, Price M, Karol J, Martin L, Murphy K, Miguel J, and Spinazzola J
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Emerging research suggests that Equine Facilitated Psychotherapy (EFP) may be beneficial for traumatized youth. In addition, complex trauma (i.e., multiple and/or prolonged developmentally adverse traumatic events which are typically interpersonal in nature) treatment research is still growing and there is a need for the development and examination of novel treatments for youth with complex trauma histories. The current article describes a promising EFP model for this population called Equine Facilitated Therapy for Complex Trauma (EFT-CT). EFT-CT embeds EFP practices within Attachment, Regulation and Competency (ARC), an extant evidence-based complex trauma treatment framework for children and adolescents. The authors provide three case studies using both observational data provided by clinicians, as well as longitudinal measures of psychosocial functioning, to illustrate the potential promise of EFT-CT. The article concludes with a discussion about implications for EFP treatment and research., Competing Interests: All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation [institutional and national] and with the Helsinki Declaration of 1975, as revised in 2000.Author C owns the company (farm, stables and dressage training center) where the EFP-CT model was developed and is primarily implemented. Authors A, B, D, E, F & G declare that they have no conflicts to report.Informed consent was obtained from all patients for being included in the study.
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- 2018
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42. The Boy Who Was Hit in the Face: Somatic Regulation and Processing of Preverbal Complex Trauma.
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Finn H, Warner E, Price M, and Spinazzola J
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Examination of novel treatment for complexly traumatized youth, in particular, those exposed to preverbal trauma, is necessary given challenges associated with effective intervention for this population. Therapies that facilitate somatic regulation have demonstrated benefit for some trauma survivors. The current article briefly reviews the emerging literature on symptoms of and treatments for complex and preverbal child trauma and describes Sensory Motor Arousal Regulation Therapy (SMART), an intervention for child and adolescent trauma with preliminary empirical support. SMART aims to enhance sensory motor engagement and promote affective, behavioral and physiological regulation using somatic regulation and sensory integration techniques. Utilizing case study methodology, the article illustrates application of SMART in treatment of a latency-aged child with history of exposure to complex and preverbal traumatic experiences. Case analysis suggests the potential contribution of enhanced somatic regulation in traumatized children toward increased relational engagement, behavioral and emotional regulation, and trauma processing., Competing Interests: Conflict of InterestThe authors declare that they have no conflict of interest., (© Springer International Publishing AG 2017, Corrected publication August/2017.)
- Published
- 2017
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43. Trauma Sensitive Yoga as a complementary treatment for posttraumatic stress disorder: A Qualitative Descriptive analysis.
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West J, Liang B, and Spinazzola J
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Research on Posttraumatic Stress Disorder and chronic childhood abuse has revealed that traditional trauma treatments often fail to fully address the complicated symptom presentation, including the somatic complaints, loss of awareness of one's emotional and physical being in the present moment, and overall lack of integration between the self and the body. The mindfulness-based intervention of hatha yoga shows promise as a complementary treatment, and focuses on personal growth in addition to symptom reduction. This qualitative study explored the experiences of thirty-one adult women with PTSD related to chronic childhood trauma who participated in a 10-week Trauma Sensitive Yoga class, specifically examining perceived changes in symptoms and personal growth. Five themes were identified that reflect participants' feelings of Gratitude and compassion, Relatedness, Acceptance, Centeredness, and Empowerment. Results and implications for research and clinical work are presented.
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- 2017
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44. Effectiveness of an Extended Yoga Treatment for Women with Chronic Posttraumatic Stress Disorder.
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Price M, Spinazzola J, Musicaro R, Turner J, Suvak M, Emerson D, and van der Kolk B
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- Adult, Chronic Disease, Female, Humans, Middle Aged, Stress Disorders, Post-Traumatic therapy, Yoga
- Abstract
Background: Yoga has been found to be an effective posttraumatic stress disorder (PTSD) treatment for a variety of trauma survivors, including females with chronic PTSD. Aim/Purpose: The current study builds on extant research by examining an extended trauma-sensitive yoga treatment for women with chronic PTSD. The study sought to optimize the results of a treatment protocol examined in a recent randomized controlled trial with a shorter duration and without assignment or monitoring of home practice., Materials and Methods: The authors examined a 20-week trauma-sensitive yoga treatment in a non-randomized single-group treatment feasibility study for women with chronic treatment-resistant PTSD (N = 9). The authors examined PTSD and dissociation symptom reduction over several assessment periods., Results: The results indicate that participants experienced significant reductions in PTSD and dissociative symptomatology above and beyond similar treatments of a shorter duration., Conclusions: The findings suggest that more intensive trauma-sensitive yoga treatment characterized by longer duration and intentional assignment and monitoring of home practice may be more advantageous for individuals with severe and chronic PTSD. The implications of the findings for the potentially more substantial role of yoga as an intervention for a subset of adults with chronic treatment-resistant PTSD are discussed.
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- 2017
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45. Treating adult survivors of childhood emotional abuse and neglect: A new framework.
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Grossman FK, Spinazzola J, Zucker M, and Hopper E
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- Humans, Surveys and Questionnaires, Adult Survivors of Child Abuse psychology, Psychotherapy methods
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This article provides the outline of a new framework for treating adult survivors of childhood emotional abuse and neglect. Component-based psychotherapy (CBP) is an evidence-informed model that bridges, synthesizes, and expands upon several existing schools, or theories, of treatment for adult survivors of traumatic stress. These include approaches to therapy that stem from more classic traditions in psychology, such as psychoanalysis, to more modern approaches including those informed by feminist thought. Moreover, CBP places particular emphasis on integration of key concepts from evidence-based treatment models developed in the past few decades predicated upon thinking and research on the effects of traumatic stress and processes of recovery for survivors. (PsycINFO Database Record, ((c) 2017 APA, all rights reserved).)
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- 2017
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46. A Randomized Controlled Study of Neurofeedback for Chronic PTSD.
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van der Kolk BA, Hodgdon H, Gapen M, Musicaro R, Suvak MK, Hamlin E, and Spinazzola J
- Subjects
- Adult, Brain-Computer Interfaces, Electroencephalography, Female, Humans, Male, Middle Aged, Neurofeedback, Research Design, Stress Disorders, Post-Traumatic diagnosis, Treatment Outcome, Stress Disorders, Post-Traumatic therapy
- Abstract
Introduction: Brain/Computer Interaction (BCI) devices are designed to alter neural signals and, thereby, mental activity. This study was a randomized, waitlist (TAU) controlled trial of a BCI, EEG neurofeedback training (NF), in patients with chronic PTSD to explore the capacity of NF to reduce PTSD symptoms and increase affect regulation capacities., Study Design: 52 individuals with chronic PTSD were randomized to either NF (n = 28) or waitlist (WL) (n = 24). They completed four evaluations, at baseline (T1), after week 6 (T2), at post-treatment (T3), and at one month follow up (T4). Assessment measures were:1. Traumatic Events Screening Inventory (T1); 2. the Clinician Administered PTSD Scale (CAPS; T1, T3, T4); 3. the Davidson Trauma Scale (DTS; T1-T4) and 4. the Inventory of Altered Self-Capacities (IASC; T1-T4). NF training occurred two times per week for 12 weeks and involved a sequential placement with T4 as the active site, P4 as the reference site., Results: Participants had experienced an average of 9.29 (SD = 2.90) different traumatic events. Post-treatment a significantly smaller proportion of NF (6/22, 27.3%) met criteria for PTSD than the WL condition (15/22, 68.2%), χ2 (n = 44, df = 1) = 7.38, p = .007. There was a significant treatment condition x time interaction (b = -10.45, t = -5.10, p< .001). Measures of tension reduction activities, affect dysregulation, and affect instability exhibited a significant Time x Condition interaction. The effect sizes of NF (d = -2.33 within, d = - 1.71 between groups) are comparable to those reported for the most effective evidence based treatments for PTSD., Discussion: Compared with the control group NF produced significant PTSD symptom improvement in individuals with chronic PTSD, as well as in affect regulation capacities. NF deserves further investigation for its potential to ameliorate PTSD and to improve affect regulation, and to clarify its mechanisms of action., Competing Interests: No competing interests
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- 2016
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47. A Silent Relic: Uremic Pericardial Effusion.
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Santos MA, Spinazzola J, and Van de Louw A
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- Cardiac Tamponade etiology, Diagnosis, Differential, Female, Humans, Kidney Failure, Chronic complications, Kidney Failure, Chronic therapy, Middle Aged, Pericardial Effusion complications, Pericardiocentesis, Renal Dialysis, Uremia complications, Uremia therapy, Cardiac Tamponade diagnosis, Cardiac Tamponade therapy, Pericardial Effusion diagnostic imaging, Pericardial Effusion therapy
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- 2016
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48. A Pilot Study of Neurofeedback for Chronic PTSD.
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Gapen M, van der Kolk BA, Hamlin E, Hirshberg L, Suvak M, and Spinazzola J
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- Adult, Chronic Disease therapy, Electroencephalography, Female, Humans, Male, Middle Aged, Pilot Projects, Treatment Outcome, Neurofeedback physiology, Stress Disorders, Post-Traumatic therapy
- Abstract
EEG Biofeedback (also known as neurofeedback) has been in use as a clinical intervention for well over 30 years; however, it has made very little impact on clinical care. One reason for this has been the difficulty in designing research to measure clinical change in the real world. While substantial evidence exists for its efficacy in treating attention deficit/hyperactivity disorder, relatively little evidence exists for its utility in other disorders including posttraumatic stress disorder (PTSD). The current study represents a "proof-of-concept" pilot for the use of neurofeedback with multiply-traumatized individuals with treatment-resistant PTSD. Participants completed 40 sessions of neurofeedback training two times per week with sensors randomly assigned (by the study coordinator, who was not blind to condition) to sensor placements of either T4-P4 or T3-T4. We found that neurofeedback significantly reduced PTSD symptoms (Davidson Trauma Scale scores averaged 69.14 at baseline to 49.26 at termination), and preceded gains in affect regulation (Inventory of Altered Self-Capacities-Affect Dysregulation scores averaged 23.63 at baseline to 17.20 at termination). We discuss a roadmap for future research.
- Published
- 2016
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49. Yoga for Adult Women with Chronic PTSD: A Long-Term Follow-Up Study.
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Rhodes A, Spinazzola J, and van der Kolk B
- Subjects
- Adult, Depression, Follow-Up Studies, Humans, Middle Aged, Regression Analysis, Self-Injurious Behavior, Stress Disorders, Post-Traumatic therapy, Yoga
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Introduction: Yoga-the integrative practice of physical postures and movement, breath exercises, and mindfulness-may serve as a useful adjunctive component of trauma-focused treatment to build skills in tolerating and modulating physiologic and affective states that have become dysregulated by trauma exposure. A previous randomized controlled study was carried out among 60 women with chronic, treatment-resistant post-traumatic stress disorder (PTSD) and associated mental health problems stemming from prolonged or multiple trauma exposures. After 10 sessions of yoga, participants exhibited statistically significant decreases in PTSD symptom severity and greater likelihood of loss of PTSD diagnosis, significant decreases in engagement in negative tension reduction activities (e.g., self-injury), and greater reductions in dissociative and depressive symptoms when compared with the control (a seminar in women's health). The current study is a long-term follow-up assessment of participants who completed this randomized controlled trial., Methods: Participants from the randomized controlled trial were invited to participate in long-term follow-up assessments approximately 1.5 years after study completion to assess whether the initial intervention and/or yoga practice after treatment was associated with additional changes. Forty-nine women completed the long-term follow-up interviews. Hierarchical regression analysis was used to examine whether treatment group status in the original study and frequency of yoga practice after the study predicted greater changes in symptoms and PTSD diagnosis., Results: Group assignment in the original randomized study was not a significant predictor of longer-term outcomes. However, frequency of continuing yoga practice significantly predicted greater decreases in PTSD symptom severity and depression symptom severity, as well as a greater likelihood of a loss of PTSD diagnosis., Conclusions: Yoga appears to be a useful treatment modality; the greatest long-term benefits are derived from more frequent yoga practice.
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- 2016
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50. Absence of γ-sarcoglycan alters the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle.
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Moorwood C, Philippou A, Spinazzola J, Keyser B, Macarak EJ, and Barton ER
- Abstract
Background: The dystrophin glycoprotein complex (DGC) is located at the sarcolemma of muscle fibers, providing structural integrity. Mutations in and loss of DGC proteins cause a spectrum of muscular dystrophies. When only the sarcoglycan subcomplex is absent, muscles display severe myofiber degeneration, but little susceptibility to contractile damage, suggesting that disease occurs not by structural deficits but through aberrant signaling, namely, loss of normal mechanotransduction signaling through the sarcoglycan complex. We extended our previous studies on mechanosensitive, γ-sarcoglycan-dependent ERK1/2 phosphorylation, to determine whether additional pathways are altered with the loss of γ-sarcoglycan., Methods: We examined mechanotransduction in the presence and absence of γ-sarcoglycan, using C2C12 myotubes, and primary cultures and isolated muscles from C57Bl/6 (C57) and γ-sarcoglycan-null (γ-SG(-/-)) mice. All were subjected to cyclic passive stretch. Signaling protein phosphorylation was determined by immunoblotting of lysates from stretched and non-stretched samples. Calcium dependence was assessed by maintaining muscles in calcium-free or tetracaine-supplemented Ringer's solution. Dependence on mTOR was determined by stretching isolated muscles in the presence or absence of rapamycin., Results: C2C12 myotube stretch caused a robust increase in P-p70S6K, but decreased P-FAK and P-ERK2. Neither Akt nor ERK1 were responsive to passive stretch. Similar but non-significant trends were observed in C57 primary cultures in response to stretch, and γ-SG(-/-) cultures displayed no p70S6K response. In contrast, in isolated muscles, p70S6K was mechanically responsive. Basal p70S6K activation was elevated in muscles of γ-SG(-/-) mice, in a calcium-independent manner. p70S6K activation increased with stretch in both C57 and γ-SG(-/-) isolated muscles, and was sustained in γ-SG(-/-) muscles, unlike the transient response in C57 muscles. Rapamycin treatment blocked all of p70S6K activation in stretched C57 muscles, and reduced downstream S6RP phosphorylation. However, even though rapamycin treatment decreased p70S6K activation in stretched γ-SG(-/-) muscles, S6RP phosphorylation remained elevated., Conclusions: p70S6K is an important component of γ-sarcoglycan-dependent mechanotransduction in skeletal muscle. Our results suggest that loss of γ-sarcoglycan uncouples the response of p70S6K to stretch and implies that γ-sarcoglycan is important for inactivation of this pathway. Overall, we assert that altered load-sensing mechanisms exist in muscular dystrophies where the sarcoglycans are absent.
- Published
- 2014
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