Author: "Spring, Denise J." - Searchworks@Jio Institute Digital Library Search Results

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185 results on '"Spring, Denise J."'

1. Telomere dysfunction alters intestinal stem cell dynamics to promote cancer

Author: LaBella, Kyle A., Hsu, Wen-Hao, Li, Jiexi, Qi, Yutao, Liu, Yonghong, Liu, Jingjing, Wu, Chia-Chin, Liu, Yang, Song, Zingzhi, Lin, Yiyun, Blecher, Jonathan M., Jiang, Shan, Shang, Xiaoying, Han, Jincheng, Spring, Denise J., Zhang, Jianhua, Xia, Yan, and DePinho, Ronald A.
Published: 2024
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2. Histone demethylase KDM5D upregulation drives sex differences in colon cancer

Author: Li, Jiexi, Lan, Zhengdao, Liao, Wenting, Horner, James W., Xu, Xueping, Liu, Jielin, Yoshihama, Yohei, Jiang, Shan, Shim, Hong Seok, Slotnik, Max, LaBella, Kyle A., Wu, Chang-Jiun, Dunner, Jr., Kenneth, Hsu, Wen-Hao, Lee, Rumi, Khanduri, Isha, Terranova, Christopher, Akdemir, Kadir, Chakravarti, Deepavali, Shang, Xiaoying, Spring, Denise J., Wang, Y. Alan, and DePinho, Ronald A.
Published: 2023
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3. Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor immunity and durable response in pancreatic cancer

Author: Gulhati, Pat, Schalck, Aislyn, Jiang, Shan, Shang, Xiaoying, Wu, Chang-Jiun, Hou, Pingping, Ruiz, Sharia Hernandez, Soto, Luisa Solis, Parra, Edwin, Ying, Haoqiang, Han, Jincheng, Dey, Prasenjit, Li, Jun, Deng, Pingna, Sei, Emi, Maeda, Dean Y., Zebala, John A., Spring, Denise J., Kim, Michael, Wang, Huamin, Maitra, Anirban, Moore, Dirk, Clise-Dwyer, Karen, Wang, Y. Alan, Navin, Nicholas E., and DePinho, Ronald A.
Published: 2023
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4. AR-negative prostate cancer is vulnerable to loss of JMJD1C demethylase

Author: Yoshihama, Yohei, LaBella, Kyle A., Kim, Eiru, Bertolet, Lori, Colic, Medina, Li, Jiexi, Shang, Xiaoying, Wu, Chang-Jiun, Spring, Denise J., Wang, Y. Alan, Hart, Traver, and DePinho, Ronald A.
Published: 2021

5. Telomere dysfunction instigates inflammation in inflammatory bowel disease

Author: Chakravarti, Deepavali, Lee, Rumi, Multani, Asha S., Santoni, Andrea, Keith, Zachery, Hsu, Wen-Hao, Change, Kyle, Reyes, Laura, Rashid, Asif, Wu, Chang-Jiun, Li, Jun, Zhang, Jiexin, Shim, Hong Seok, Chandra, Krishna, Deng, Pingna, Spring, Denise J., Nielsen, Ole Haagen, Riis, Lene Buhl, Mayigegowda, Kavya Kelagere, Blutt, Sarah E., Zhang, Jianhua, Younes, Mamoun, DuPont, Andrew, Thirumurthi, Selvi, Vilar, Eduardo, Estes, Mary K., Colla, Simona, Shroyer, Noah F., and DePinho, Ronald A.
Published: 2021

6. Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth

Author: Hu, Baoli, Wang, Qianghu, Wang, Y Alan, Hua, Sujun, Sauvé, Charles-Etienne Gabriel, Ong, Derrick, Lan, Zheng D, Chang, Qing, Ho, Yan Wing, Monasterio, Marta Moreno, Lu, Xin, Zhong, Yi, Zhang, Jianhua, Deng, Pingna, Tan, Zhi, Wang, Guocan, Liao, Wen-Ting, Corley, Lynda J, Yan, Haiyan, Zhang, Junxia, You, Yongping, Liu, Ning, Cai, Linbo, Finocchiaro, Gaetano, Phillips, Joanna J, Berger, Mitchel S, Spring, Denise J, Hu, Jian, Sulman, Erik P, Fuller, Gregory N, Chin, Lynda, Verhaak, Roeland GW, and DePinho, Ronald A
Subjects: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Neurosciences, Brain Disorders, Stem Cell Research - Nonembryonic - Non-Human, Clinical Research, Cancer, Genetics, Brain Cancer, Stem Cell Research, Stem Cell Research - Nonembryonic - Human, Rare Diseases, 2.1 Biological and endogenous factors, Endothelial Cells, Epigenomics, Gene Expression Regulation, Neoplastic, Glioblastoma, Homeodomain Proteins, Humans, Neoplasm Invasiveness, Neural Stem Cells, PAX6 Transcription Factor, Proto-Oncogene Proteins c-akt, Transcription Factors, Wnt-5a Protein, cancer stem cell differentiation, glioblastoma, recurrence, tumor microenvironment, Biological Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract: Glioblastoma stem cells (GSCs) are implicated in tumor neovascularization, invasiveness, and therapeutic resistance. To illuminate mechanisms governing these hallmark features, we developed a de novo glioblastoma multiforme (GBM) model derived from immortalized human neural stem/progenitor cells (hNSCs) to enable precise system-level comparisons of pre-malignant and oncogene-induced malignant states of NSCs. Integrated transcriptomic and epigenomic analyses uncovered a PAX6/DLX5 transcriptional program driving WNT5A-mediated GSC differentiation into endothelial-like cells (GdECs). GdECs recruit existing endothelial cells to promote peritumoral satellite lesions, which serve as a niche supporting the growth of invasive glioma cells away from the primary tumor. Clinical data reveal higher WNT5A and GdECs expression in peritumoral and recurrent GBMs relative to matched intratumoral and primary GBMs, respectively, supporting WNT5A-mediated GSC differentiation and invasive growth in disease recurrence. Thus, the PAX6/DLX5-WNT5A axis governs the diffuse spread of glioma cells throughout the brain parenchyma, contributing to the lethality of GBM.
Published: 2016

7. Abstract IA20: Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer

Author: Han, Jincheng, primary, Xu, Jiaqian, additional, Liu, Yonghong, additional, Liang, Shaoheng, additional, LaBella, Kyle A., additional, Chakravarti, Deepavali, additional, Spring, Denise J., additional, Xia, Yan, additional, and DePinho, Ronald A., additional
Published: 2024
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8. Data from Oncogenic KRAS Drives Lipofibrogenesis to Promote Angiogenesis and Colon Cancer Progression

Author: Hsu, Wen-Hao, primary, LaBella, Kyle A., primary, Lin, Yiyun, primary, Xu, Ping, primary, Lee, Rumi, primary, Hsieh, Cheng-En, primary, Yang, Lei, primary, Zhou, Ashley, primary, Blecher, Jonathan M., primary, Wu, Chang-Jiun, primary, Lin, Kangyu, primary, Shang, Xiaoying, primary, Jiang, Shan, primary, Spring, Denise J., primary, Xia, Yan, primary, Chen, Peiwen, primary, Shen, John Paul, primary, Kopetz, Scott, primary, and DePinho, Ronald A., primary
Published: 2023
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9. Supplementary Figure S7 from Oncogenic KRAS Drives Lipofibrogenesis to Promote Angiogenesis and Colon Cancer Progression

Author: Hsu, Wen-Hao, primary, LaBella, Kyle A., primary, Lin, Yiyun, primary, Xu, Ping, primary, Lee, Rumi, primary, Hsieh, Cheng-En, primary, Yang, Lei, primary, Zhou, Ashley, primary, Blecher, Jonathan M., primary, Wu, Chang-Jiun, primary, Lin, Kangyu, primary, Shang, Xiaoying, primary, Jiang, Shan, primary, Spring, Denise J., primary, Xia, Yan, primary, Chen, Peiwen, primary, Shen, John Paul, primary, Kopetz, Scott, primary, and DePinho, Ronald A., primary
Published: 2023
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10. Supplementary Table S5 from Oncogenic KRAS Drives Lipofibrogenesis to Promote Angiogenesis and Colon Cancer Progression

Author: Hsu, Wen-Hao, primary, LaBella, Kyle A., primary, Lin, Yiyun, primary, Xu, Ping, primary, Lee, Rumi, primary, Hsieh, Cheng-En, primary, Yang, Lei, primary, Zhou, Ashley, primary, Blecher, Jonathan M., primary, Wu, Chang-Jiun, primary, Lin, Kangyu, primary, Shang, Xiaoying, primary, Jiang, Shan, primary, Spring, Denise J., primary, Xia, Yan, primary, Chen, Peiwen, primary, Shen, John Paul, primary, Kopetz, Scott, primary, and DePinho, Ronald A., primary
Published: 2023
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11. PAF promotes stemness and radioresistance of glioma stem cells

Author: Ong, Derrick Sek Tong, Hu, Baoli, Ho, Yan Wing, Sauvé, Charles-Etienne Gabriel, Bristow, Christopher A., Wang, Qianghu, Multani, Asha S., Chen, Peiwen, Nezi, Luigi, Jiang, Shan, Gorman, Claire Elizabeth, Monasterio, Marta Moreno, Koul, Dimpy, Marchesini, Matteo, Colla, Simona, Jin, Eun-Jung, Sulman, Erik P., Spring, Denise J., Yung, Wai-Kwan Alfred, Verhaak, Roel G. W., Chin, Lynda, Wang, Y. Alan, and DePinho, Ronald A.
Published: 2017

12. Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer

Author: Han, Jincheng, primary, Xu, Jiaqian, additional, Liu, Yonghong, additional, Liang, Shaoheng, additional, LaBella, Kyle A., additional, Chakravarti, Deepavali, additional, Spring, Denise J., additional, Xia, Yan, additional, and DePinho, Ronald A., additional
Published: 2023
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13. Oncogenic KRAS drives lipo-fibrogenesis to promote angiogenesis and colon cancer progression

Author: Hsu, Wen-Hao, primary, LaBella, Kyle A., additional, Lin, Yiyun, additional, Xu, Ping, additional, Lee, Rumi, additional, Hsieh, Cheng-En, additional, Yang, Lei, additional, Zhou, Ashley, additional, Blecher, Jonathan M., additional, Wu, Chang-Jiun, additional, Lin, Kangyu, additional, Shang, Xiaoying, additional, Jiang, Shan, additional, Spring, Denise J., additional, Xia, Yan, additional, Chen, Peiwen, additional, Shen, John Paul., additional, Kopetz, Scott, additional, and DePinho, Ronald A., additional
Published: 2023
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14. Telomere dysfunction activates YAP1 to drive tissue inflammation

Author: Chakravarti, Deepavali, Hu, Baoli, Mao, Xizeng, Rashid, Asif, Li, Jiexi, Li, Jun, Liao, Wen-ting, Whitley, Elizabeth M., Dey, Prasenjit, Hou, Pingping, LaBella, Kyle A., Chang, Andrew, Wang, Guocan, Spring, Denise J., Deng, Pingna, Zhao, Di, Liang, Xin, Lan, Zhengdao, Lin, Yiyun, Sarkar, Sharmistha, Terranova, Christopher, Deribe, Yonathan Lissanu, Blutt, Sarah E., Okhuysen, Pablo, Zhang, Jianhua, Vilar, Eduardo, Nielsen, Ole Haagen, Dupont, Andrew, Younes, Mamoun, Patel, Kalyani R., Shroyer, Noah F., Rai, Kunal, Estes, Mary K., Wang, Y. Alan, Bertuch, Alison A., and DePinho, Ronald A.
Published: 2020
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15. Supplementary Data from Synthetic Essentiality of Tryptophan 2,3-Dioxygenase 2 in APC-Mutated Colorectal Cancer

Author: Lee, Rumi, primary, Li, Jiexi, primary, Li, Jun, primary, Wu, Chang-Jiun, primary, Jiang, Shan, primary, Hsu, Wen-Hao, primary, Chakravarti, Deepavali, primary, Chen, Peiwen, primary, LaBella, Kyle A., primary, Li, Jing, primary, Spring, Denise J., primary, Zhao, Di, primary, Wang, Y. Alan, primary, and DePinho, Ronald A., primary
Published: 2023
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16. Supplementary Table from Synthetic Essentiality of Tryptophan 2,3-Dioxygenase 2 in APC-Mutated Colorectal Cancer

Author: Lee, Rumi, primary, Li, Jiexi, primary, Li, Jun, primary, Wu, Chang-Jiun, primary, Jiang, Shan, primary, Hsu, Wen-Hao, primary, Chakravarti, Deepavali, primary, Chen, Peiwen, primary, LaBella, Kyle A., primary, Li, Jing, primary, Spring, Denise J., primary, Zhao, Di, primary, Wang, Y. Alan, primary, and DePinho, Ronald A., primary
Published: 2023
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17. Data from Synthetic Essentiality of Tryptophan 2,3-Dioxygenase 2 in APC-Mutated Colorectal Cancer

Author: Lee, Rumi, primary, Li, Jiexi, primary, Li, Jun, primary, Wu, Chang-Jiun, primary, Jiang, Shan, primary, Hsu, Wen-Hao, primary, Chakravarti, Deepavali, primary, Chen, Peiwen, primary, LaBella, Kyle A., primary, Li, Jing, primary, Spring, Denise J., primary, Zhao, Di, primary, Wang, Y. Alan, primary, and DePinho, Ronald A., primary
Published: 2023
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18. Supplementary Figure S6 from Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment

Author: Chen, Peiwen, primary, Hsu, Wen-Hao, primary, Chang, Andrew, primary, Tan, Zhi, primary, Lan, Zhengdao, primary, Zhou, Ashley, primary, Spring, Denise J., primary, Lang, Frederick F., primary, Wang, Y. Alan, primary, and DePinho, Ronald A., primary
Published: 2023
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19. Data from Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment

Author: Chen, Peiwen, primary, Hsu, Wen-Hao, primary, Chang, Andrew, primary, Tan, Zhi, primary, Lan, Zhengdao, primary, Zhou, Ashley, primary, Spring, Denise J., primary, Lang, Frederick F., primary, Wang, Y. Alan, primary, and DePinho, Ronald A., primary
Published: 2023
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20. Supplementary Table S1 from Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment

Author: Chen, Peiwen, primary, Hsu, Wen-Hao, primary, Chang, Andrew, primary, Tan, Zhi, primary, Lan, Zhengdao, primary, Zhou, Ashley, primary, Spring, Denise J., primary, Lang, Frederick F., primary, Wang, Y. Alan, primary, and DePinho, Ronald A., primary
Published: 2023
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21. Supplementary Figures S1-9 from Tumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer

Author: Hou, Pingping, primary, Kapoor, Avnish, primary, Zhang, Qiang, primary, Li, Jiexi, primary, Wu, Chang-Jiun, primary, Li, Jun, primary, Lan, Zhengdao, primary, Tang, Ming, primary, Ma, Xingdi, primary, Ackroyd, Jeffrey J., primary, Kalluri, Raghu, primary, Zhang, Jianhua, primary, Jiang, Shan, primary, Spring, Denise J., primary, Wang, Y. Alan, primary, and DePinho, Ronald A., primary
Published: 2023
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22. Data from Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment

Author: Dey, Prasenjit, primary, Li, Jun, primary, Zhang, Jianhua, primary, Chaurasiya, Surendra, primary, Strom, Anders, primary, Wang, Huamin, primary, Liao, Wen-Ting, primary, Cavallaro, Frederick, primary, Denz, Parker, primary, Bernard, Vincent, primary, Yen, Er-Yen, primary, Genovese, Giannicola, primary, Gulhati, Pat, primary, Liu, Jielin, primary, Chakravarti, Deepavali, primary, Deng, Pingna, primary, Zhang, Tingxin, primary, Carbone, Federica, primary, Chang, Qing, primary, Ying, Haoqiang, primary, Shang, Xiaoying, primary, Spring, Denise J., primary, Ghosh, Bidyut, primary, Putluri, Nagireddy, primary, Maitra, Anirban, primary, Wang, Y. Alan, primary, and DePinho, Ronald A., primary
Published: 2023
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23. Supplementary Table S1 from Tumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer

Author: Hou, Pingping, primary, Kapoor, Avnish, primary, Zhang, Qiang, primary, Li, Jiexi, primary, Wu, Chang-Jiun, primary, Li, Jun, primary, Lan, Zhengdao, primary, Tang, Ming, primary, Ma, Xingdi, primary, Ackroyd, Jeffrey J., primary, Kalluri, Raghu, primary, Zhang, Jianhua, primary, Jiang, Shan, primary, Spring, Denise J., primary, Wang, Y. Alan, primary, and DePinho, Ronald A., primary
Published: 2023
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24. Data from Tumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer

Author: Hou, Pingping, primary, Kapoor, Avnish, primary, Zhang, Qiang, primary, Li, Jiexi, primary, Wu, Chang-Jiun, primary, Li, Jun, primary, Lan, Zhengdao, primary, Tang, Ming, primary, Ma, Xingdi, primary, Ackroyd, Jeffrey J., primary, Kalluri, Raghu, primary, Zhang, Jianhua, primary, Jiang, Shan, primary, Spring, Denise J., primary, Wang, Y. Alan, primary, and DePinho, Ronald A., primary
Published: 2023
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25. Supplementary Data from Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment

Author: Dey, Prasenjit, primary, Li, Jun, primary, Zhang, Jianhua, primary, Chaurasiya, Surendra, primary, Strom, Anders, primary, Wang, Huamin, primary, Liao, Wen-Ting, primary, Cavallaro, Frederick, primary, Denz, Parker, primary, Bernard, Vincent, primary, Yen, Er-Yen, primary, Genovese, Giannicola, primary, Gulhati, Pat, primary, Liu, Jielin, primary, Chakravarti, Deepavali, primary, Deng, Pingna, primary, Zhang, Tingxin, primary, Carbone, Federica, primary, Chang, Qing, primary, Ying, Haoqiang, primary, Shang, Xiaoying, primary, Spring, Denise J., primary, Ghosh, Bidyut, primary, Putluri, Nagireddy, primary, Maitra, Anirban, primary, Wang, Y. Alan, primary, and DePinho, Ronald A., primary
Published: 2023
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26. Cancer Genomics in Clinical Context

Author: Chin, Lynda, Wargo, Jennifer A., Spring, Denise J., Kantarjian, Hagop, and Futreal, P. Andrew
Published: 2015
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27. Effective combinatorial immunotherapy for castration-resistant prostate cancer

Author: Lu, Xin, Horner, James W., Paul, Erin, Shang, Xiaoying, Troncoso, Patricia, Deng, Pingna, Jiang, Shan, Chang, Qing, Spring, Denise J., Sharma, Padmanee, Zebala, John A., Maeda, Dean Y., Wang, Y. Alan, and DePinho, Ronald A.
Subjects: Care and treatment, Analysis, Patient outcomes, Immunotherapy -- Patient outcomes, Prostate cancer -- Care and treatment, Cancer metastasis -- Analysis
Abstract: Author(s): Xin Lu [1]; James W. Horner [2]; Erin Paul [2]; Xiaoying Shang [1]; Patricia Troncoso [3]; Pingna Deng [1]; Shan Jiang [2]; Qing Chang [2]; Denise J. Spring [1]; [...]
Published: 2017
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28. Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor immunity and durable response in pancreatic cancer

Author: Gulhati, Pat, primary, Schalck, Aislyn, additional, Jiang, Shan, additional, Shang, Xiaoying, additional, Wu, Chang-Jiun, additional, Hou, Pingping, additional, Ruiz, Sharia Hernandez, additional, Soto, Luisa Solis, additional, Parra, Edwin, additional, Ying, Haoqiang, additional, Han, Jincheng, additional, Dey, Prasenjit, additional, Li, Jun, additional, Deng, Pingna, additional, Sei, Emi, additional, Maeda, Dean Y., additional, Zebala, John A., additional, Spring, Denise J., additional, Kim, Michael, additional, Wang, Huamin, additional, Maitra, Anirban, additional, Moore, Dirk, additional, Clise-Dwyer, Karen, additional, Wang, Y. Alan, additional, Navin, Nicholas E., additional, and DePinho, Ronald A., additional
Published: 2022
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29. Abstract PR011: Histone demethylase KDM5D drives sex-specific differences in colorectal cancer

Author: Li, Jiexi, primary, Lan, Zhengdao, additional, Liao, Wenting, additional, Horner, James W., additional, Liu, Jielin, additional, Jiang, Shan, additional, Shim, Hong S., additional, Slotnik, Max, additional, LaBella, Kyle A., additional, Hsu, Wen-Hao, additional, Spring, Denise J., additional, Wang, Y. Alan, additional, and DePinho, Ronald A., additional
Published: 2022
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30. Abstract IA014: Synthetic essentiality identifies TDO2 as a key target in APC-deficient CRC

Author: Lee, Rumi, primary, Li, Jiexi, additional, Li, Jun, additional, Wu, Chang-Jiun, additional, Jiang, Shan, additional, Hsu, Wen-Hao, additional, Chakravarti, Deepavali, additional, Chen, Peiwen, additional, LaBella, Kyle A., additional, Li, Jing, additional, Spring, Denise J., additional, Zhao, Di, additional, Wang, Y. Alan, additional, and DePinho, Ronald A., additional
Published: 2022
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31. Synthetic Essentiality of Tryptophan 2,3-Dioxygenase 2 in APC-Mutated Colorectal Cancer

Author: Lee, Rumi, primary, Li, Jiexi, additional, Li, Jun, additional, Wu, Chang-Jiun, additional, Jiang, Shan, additional, Hsu, Wen-Hao, additional, Chakravarti, Deepavali, additional, Chen, Peiwen, additional, LaBella, Kyle A., additional, Li, Jing, additional, Spring, Denise J., additional, Zhao, Di, additional, Wang, Y. Alan, additional, and DePinho, Ronald A., additional
Published: 2022
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32. Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer

Author: Zhao, Di, Lu, Xin, Wang, Guocan, Lan, Zhengdao, Liao, Wenting, Li, Jun, Liang, Xin, Chen, Jasper Robin, Shah, Sagar, Shang, Xiaoying, Tang, Ming, Deng, Pingna, Dey, Prasenjit, Chakravarti, Deepavali, Chen, Peiwen, Spring, Denise J., Navone, Nora M., Troncoso, Patricia, Zhang, Jianhua, Wang, Alan Y., and DePinho, Ronald A.
Published: 2017
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33. Histone demethylase KDM5D drives sex-specific differences in colorectal cancer

Author: Li, Jiexi, primary, Lao, Zhengdao, additional, Liao, Wenting, additional, Horner, James W., additional, Xu, Xueping, additional, Liu, Jielin, additional, Yoshihama, Yohei, additional, Jiang, Shan, additional, Shim, Hong Seok, additional, Slotnik, Max, additional, Wu, Chang-Jiun, additional, Dunner Jr., Kenneth, additional, Lee, Rumi, additional, Khanduri, Isha, additional, Terranova, Christopher, additional, Akdemir, Kadir Caner, additional, Chakravarti, Deepavali, additional, LaBella, Kyle, additional, Hsu, Wen-Hao, additional, Spring, Denise J., additional, Wang, Y. Alan, additional, and Depinho, Ronald A., additional
Published: 2022
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34. Chromatin Regulator CHD1 Remodels the Immunosuppressive Tumor Microenvironment in PTEN-Deficient Prostate Cancer

Author: Zhao, Di, primary, Cai, Li, additional, Lu, Xin, additional, Liang, Xin, additional, Li, Jiexi, additional, Chen, Peiwen, additional, Ittmann, Michael, additional, Shang, Xiaoying, additional, Jiang, Shan, additional, Li, Haoyan, additional, Meng, Chenling, additional, Flores, Ivonne, additional, Song, Jian H., additional, Horner, James W., additional, Lan, Zhengdao, additional, Wu, Chang-Jiun, additional, Li, Jun, additional, Chang, Qing, additional, Chen, Ko-Chien, additional, Wang, Guocan, additional, Deng, Pingna, additional, Spring, Denise J., additional, Wang, Y. Alan, additional, and DePinho, Ronald A., additional
Published: 2020
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35. Tumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer

Author: Hou, Pingping, primary, Kapoor, Avnish, additional, Zhang, Qiang, additional, Li, Jiexi, additional, Wu, Chang-Jiun, additional, Li, Jun, additional, Lan, Zhengdao, additional, Tang, Ming, additional, Ma, Xingdi, additional, Ackroyd, Jeffrey J., additional, Kalluri, Raghu, additional, Zhang, Jianhua, additional, Jiang, Shan, additional, Spring, Denise J., additional, Wang, Y. Alan, additional, and DePinho, Ronald A., additional
Published: 2020
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36. Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment

Author: Dey, Prasenjit, primary, Li, Jun, additional, Zhang, Jianhua, additional, Chaurasiya, Surendra, additional, Strom, Anders, additional, Wang, Huamin, additional, Liao, Wen-Ting, additional, Cavallaro, Frederick, additional, Denz, Parker, additional, Bernard, Vincent, additional, Yen, Er-Yen, additional, Genovese, Giannicola, additional, Gulhati, Pat, additional, Liu, Jielin, additional, Chakravarti, Deepavali, additional, Deng, Pingna, additional, Zhang, Tingxin, additional, Carbone, Federica, additional, Chang, Qing, additional, Ying, Haoqiang, additional, Shang, Xiaoying, additional, Spring, Denise J., additional, Ghosh, Bidyut, additional, Putluri, Nagireddy, additional, Maitra, Anirban, additional, Wang, Y. Alan, additional, and DePinho, Ronald A., additional
Published: 2020
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37. Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment

Author: Chen, Peiwen, primary, Hsu, Wen-Hao, additional, Chang, Andrew, additional, Tan, Zhi, additional, Lan, Zhengdao, additional, Zhou, Ashley, additional, Spring, Denise J., additional, Lang, Frederick F., additional, Wang, Y. Alan, additional, and DePinho, Ronald A., additional
Published: 2020
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38. Specific inhibition of p38 mitogen-activated protein kinase with FR167653 attenuates vascular proliferation in monocrotaline-induced pulmonary hypertension in rats

Author: Lu, Jun, Shimpo, Hideto, Shimamoto, Akira, Chong, Albert J., Hampton, Craig R., Spring, Denise J., Yada, Masaki, Takao, Motoshi, Onoda, Koji, Yada, Isao, Pohlman, Timothy H., and Verrier, Edward D.
Published: 2004
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39. FR167653 diminishes infarct size in a murine model of myocardial ischemia-reperfusion injury

Author: Yada, Masaki, Shimamoto, Akira, Hampton, Craig R., Chong, Albert J., Takayama, Hiroo, Rothnie, Christine L., Spring, Denise J., Shimpo, Hideto, Yada, Isao, Pohlman, Timothy H., and Verrier, Edward D.
Published: 2004
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40. Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart

Author: Chong, Albert J., Shimamoto, Akira, Hampton, Craig R., Takayama, Hiroo, Spring, Denise J., Rothnie, Christine L., Yada, Masaki, Pohlman, Timothy H., and Verrier, Edward D.
Published: 2004
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41. AR-negative prostate cancer is vulnerable to loss of JMJD1C demethylase.

Author: Yohei Yoshihama, LaBella, Kyle A., Eiru Kim, Bertolet, Lori, Colic, Medina, Jiexi Li, Xiaoying Shang, Chang-Jiun Wu, Spring, Denise J., Wang, Y. Alan, Hart, Traver, and DePinho, Ronald A.
Subjects: PROSTATE cancer, HEMOPHILIACS, DEMETHYLASE, PROSTATE cancer patients, TUMOR necrosis factors, CURCUMIN, DRUG target
Abstract: Prostate cancer is a leading cause of cancer-related mortality in men. The widespread use of androgen receptor (AR) inhibitors has generated an increased incidence of AR-negative prostate cancer, triggering the need for effective therapies for such patients. Here, analysis of public genome-wide CRISPR screens in human prostate cancer cell lines identified histone demethylase JMJD1C (KDM3C) as an AR-negative context-specific vulnerability. Secondary validation studies in multiple cell lines and organoids, including isogenic models, confirmed that small hairpin RNA (shRNA)-mediated depletion of JMJD1C potently inhibited growth specifically in AR-negative prostate cancer cells. To explore the cooperative interactions of AR and JMJD1C, we performed comparative transcriptomics of 1) isogenic AR-positive versus AR-negative prostate cancer cells, 2) AR-positive versus AR-negative prostate cancer tumors, and 3) isogenic JMJD1C-expressing versus JMJD1C-depleted AR-negative prostate cancer cells. Loss of AR or JMJD1C generates a modest tumor necrosis factor alpha (TNFα) signature, whereas combined loss of AR and JMJD1C strongly up-regulates the TNFα signature in human prostate cancer, suggesting TNFα signaling as a point of convergence for the combined actions of AR and JMJD1C. Correspondingly, AR-negative prostate cancer cells showed exquisite sensitivity to TNFα treatment and, conversely, TNFα pathway inhibition via inhibition of its downstream effector MAP4K4 partially reversed the growth defect of JMJD1C-depleted AR-negative prostate cancer cells. Given the deleterious systemic side effects of TNFα therapy in humans and the viability of JMJD1C-knockout mice, the identification of JMJD1C inhibition as a specific vulnerability in AR-negative prostate cancer may provide an alternative drug target for prostate cancer patients progressing on AR inhibitor therapy. [ABSTRACT FROM AUTHOR]
Published: 2021
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42. USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation

Author: Hou, Pingping, primary, Ma, Xingdi, additional, Zhang, Qiang, additional, Wu, Chang-Jiun, additional, Liao, Wenting, additional, Li, Jun, additional, Wang, Huamin, additional, Zhao, Jun, additional, Zhou, Xin, additional, Guan, Carolyn, additional, Ackroyd, Jeffery, additional, Jiang, Shan, additional, Zhang, Jianhua, additional, Spring, Denise J., additional, Wang, Y. Alan, additional, and DePinho, Ronald A., additional
Published: 2019
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43. Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma

Author: Chen, Peiwen, primary, Zhao, Di, additional, Li, Jun, additional, Liang, Xin, additional, Li, Jiexi, additional, Chang, Andrew, additional, Henry, Verlene K., additional, Lan, Zhengdao, additional, Spring, Denise J., additional, Rao, Ganesh, additional, Wang, Y. Alan, additional, and DePinho, Ronald A., additional
Published: 2019
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44. KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer

Author: Liao, Wenting, primary, Overman, Michael J., additional, Boutin, Adam T., additional, Shang, Xiaoying, additional, Zhao, Di, additional, Dey, Prasenjit, additional, Li, Jiexi, additional, Wang, Guocan, additional, Lan, Zhengdao, additional, Li, Jun, additional, Tang, Ming, additional, Jiang, Shan, additional, Ma, Xingdi, additional, Chen, Peiwen, additional, Katkhuda, Riham, additional, Korphaisarn, Krittiya, additional, Chakravarti, Deepavali, additional, Chang, Andrew, additional, Spring, Denise J., additional, Chang, Qing, additional, Zhang, Jianhua, additional, Maru, Dipen M., additional, Maeda, Dean Y., additional, Zebala, John A., additional, Kopetz, Scott, additional, Wang, Y. Alan, additional, and DePinho, Ronald A., additional
Published: 2019
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45. Genetics and biology of prostate cancer

Author: Wang, Guocan, primary, Zhao, Di, additional, Spring, Denise J., additional, and DePinho, Ronald A., additional
Published: 2018
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46. p90RSK Is a Serum-stimulated Na+/H+ Exchanger Isoform-1 Kinase: REGULATORY PHOSPHORYLATION OF SERINE 703 OF Na+/H+ EXCHANGER ISOFORM-1

Author: Takahashi, Eiichi, Abe, Jun-ichi, Gallis, Byron, Aebersold, Ruedi, Spring, Denise J., Krebs, Edwin G., and Berk, Bradford C.
Published: 1999
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47. Erratum: Effective combinatorial immunotherapy for castration-resistant prostate cancer

Author: Lu, Xin, Horner, James W., Paul, Erin, Shang, Xiaoying, Troncoso, Patricia, Deng, Pingna, Jiang, Shan, Chang, Qing, Spring, Denise J., Sharma, Padmanee, Zebala, John A., Maeda, Dean Y., Wang, Y. Alan, and DePinho, Ronald A.
Abstract: Author(s): Xin Lu; James W. Horner; Erin Paul; Xiaoying Shang; Patricia Troncoso; Pingna Deng; Shan Jiang; Qing Chang; Denise J. Spring; Padmanee Sharma; John A. Zebala; Dean Y. Maeda; Y. [...]
Published: 2017
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48. PAF promotes stemness and radioresistance of glioma stem cells.

Author: Sek Tong Ong, Derrick, Baoli Hu, Yan Wing Ho, Sauvé, Charles-Etienne Gabriel, Bristow, Christopher A., Qianghu Wang, Multani, Asha S., Peiwen Chen, Nezi, Luigi, Shan Jiang, Gorman, Claire Elizabeth, Monasterio, Marta Moreno, Koul, Dimpy, Marchesini, Matteo, Colla, Simona, Eun-Jung Jin, Sulman, Erik P., Spring, Denise J., Wai-Kwan Alfred Yung, and Verhaak, Roel G. W.
Subjects: GLIOBLASTOMA multiforme treatment, PROLIFERATING cell nuclear antigen, CANCER stem cells, CANCER radiotherapy, GLIOMAS, GENETIC overexpression
Abstract: An integrated genomic and functional analysis to elucidate DNA damage signaling factors promoting self-renewal of glioma stem cells (GSCs) identified proliferating cell nuclear antigen (PCNA)- associated factor (PAF) up-regulation in glioblastoma. PAF is preferentially overexpressed in GSCs. Its depletion impairs maintenance of self-renewal without promoting differentiation and reduces tumorinitiating cell frequency. Combined transcriptomic and metabolomic analyses revealed that PAF supports GSC maintenance, in part, by influencing DNA replication and pyrimidine metabolism pathways. PAF interacts with PCNA and regulates PCNA-associated DNA translesion synthesis (TLS); consequently, PAF depletion in combination with radiation generated fewer tumorspheres compared with radiation alone. Correspondingly, pharmacological impairment of DNA replication and TLS phenocopied the effect of PAF depletion in compromising GSC self-renewal and radioresistance, providing preclinical proof of principle that combined TLS inhibition and radiation therapy may be a viable therapeutic option in the treatment of glioblastoma multiforme (GBM). [ABSTRACT FROM AUTHOR]
Published: 2017
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49. Inhibition of Toll-like Receptor 4 With Eritoran Attenuates Myocardial Ischemia-Reperfusion Injury

Author: Shimamoto, Akira, primary, Chong, Albert J., additional, Yada, Masaki, additional, Shomura, Shin, additional, Takayama, Hiroo, additional, Fleisig, Ani J., additional, Agnew, Matthew L., additional, Hampton, Craig R., additional, Rothnie, Christine L., additional, Spring, Denise J., additional, Pohlman, Timothy H., additional, Shimpo, Hideto, additional, and Verrier, Edward D., additional
Published: 2006
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50. Deletion of 11 Amino Acids in p90rsk -mo-1Abolishes Kinase Activity

Author: Spring, Denise J., primary and Krebs, Edwin G., additional
Published: 1999
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