22 results on '"Squadrelli Saraceno, M."'
Search Results
2. Alternating cisplatinum and VAC ineffective in end stage squamous cell carcinoma of the head and neck
- Author
-
Siodlak, M.Z., Stell, P.M., Wilson, J.A., Green, J.A., Allison, R.S., Adler, D., and Squadrelli-Saraceno, M.
- Subjects
Cisplatin -- Evaluation ,Squamous cell carcinoma ,Cyclophosphamide -- Evaluation ,Vincristine -- Evaluation ,Chemotherapy -- Evaluation ,Head and neck cancer ,Health - Abstract
Squamous cell carcinoma, a cancer of the cells that form the skin and other membranes, is very hard to treat when it occurs in the head and neck. Various forms of chemotherapy with drugs used alone or in combination have been tried. Regimens that include the drug cisplatinum in combination with other agents have been said to be superior. Cisplatinum alone is known to be the best single agent for end stage (very advanced) squamous cell carcinoma of the head and neck. VAC, a combination of vincristine, adriamycin and cyclophosphamide, is also known to be effective. In this study, 16 patients who had end stage squamous cell carcinoma of the head and neck were treated with cisplatinum alternating with VAC. Eight of the study patients had treatment beginning with cisplatinum followed by VAC; the other eight began with VAC, followed by cisplatinum. The authors originally planned to have 20 patients in the study, but did not because they found that the first 16 patients did less well than those who had received cisplatinum alone in a previous study, in which patients survived for an average of 180 days. In another previous study, patients survived with no treatment for an average of 70 days. The median survival time in this study of VAC and cisplatinum was 62 days, and only two patients achieved any response at all. (Consumer Summary produced by Reliance Medical Information, Inc.)
- Published
- 1990
3. Autonomous Reparative Unit (ARU): a new concept of repairing free flap donor site with local full-thickness skin graft
- Author
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Squadrelli-Saraceno, M, Compan, A, Bimbi, G, Gatto, L, Riccio, S, and Colombo, S
- Subjects
Oropharyngeal Neoplasms ,Technical note ,Tissue and Organ Harvesting ,Humans ,Mouth Neoplasms ,Skin Transplantation ,Surgical Flaps ,Follow-Up Studies - Abstract
Usually, harvesting free flap in the limbs creates an inevitable sequence of aesthetic damage not only in the donor site but also in the area of the graft used to repair the free flap donor site. Aim of the study was to standardize a simple method, defined Autonomous Reparative Unit, that allows closing of the donor site defects with a skin graft from the adjacent cutaneous area, avoiding further aesthetic damage in a third area. We define the "Autonomous Reparative Unit" as the rectangular shaped skin area of the flap and the dermoepidermic skin graft designed as an isoscele triangle with the base adjacent to the smaller side of the flap defect. From 2003 to 2008, at the Fondazione IRCCS Istituto Nationale Tumori of Milan, 143 free radial forearm flaps and 42 free osteofasciocutaneous fibula flaps have been performed for head and neck cancer. The autonomous reparative unit has been applicable in 177 cases (92.1%). The autonomous reparative unit method allows a "standard"primary reconstructive unit to be created which can be used in a single or in multiple ways thus avoiding an additional surgical scar and a subsequent additional aesthetic impairment.
- Published
- 2010
4. Patients' survival after free flap reconstructive surgery of head and neck squamous cell carcinoma: a retrospective multicentre study
- Author
-
Salvatori, P, Paradisi, S, Calabrese, L, Zani, A, Cantù, G, Cappiello, J, Benazzo, M, Bozzetti, A, Bellocchi, G, Rinaldi Ceroni, A, Succo, G, Pastore, A, Chiesa, F, Riccio, S, Piazza, C, Occhini, A, Sozzi, D, Damiani, V, Caliceti, U, Crosetti, E, Pelucchi, S, Squadrelli Saraceno, M, Podrecca, S, Podrecca, S., BOZZETTI, ALBERTO, SOZZI, DAVIDE, Salvatori, P, Paradisi, S, Calabrese, L, Zani, A, Cantù, G, Cappiello, J, Benazzo, M, Bozzetti, A, Bellocchi, G, Rinaldi Ceroni, A, Succo, G, Pastore, A, Chiesa, F, Riccio, S, Piazza, C, Occhini, A, Sozzi, D, Damiani, V, Caliceti, U, Crosetti, E, Pelucchi, S, Squadrelli Saraceno, M, Podrecca, S, Podrecca, S., BOZZETTI, ALBERTO, and SOZZI, DAVIDE
- Abstract
Head and neck squamous cell carcinoma of the (HNSCC) represents approximately 5% of malignant tumours in Italy. HNSCC are commonly treated with surgery or radiotherapy, or a combination of such therapies. The objectives of treatment are maximum cure rate balanced with organ preservation, restoration of form and function, reduction of morbidities and improvement or maintenance of the patient's quality of life. Immediate reconstructive surgery: local, regional or free flaps are now widely advised in the treatment of these patients. Microsurgical transfer requires expertise, is time and resource consuming, and as a whole requires substantial costs. These considerations introduce some concerns about the wide or indiscriminate use of free flap reconstructive surgery. When considering cost-benefit outcomes of such treatment, the main objective is undoubtedly, survival. This data is underreported in the current literature, whereas functional outcomes of free flaps have been largely diffused and accepted. This study collects data from 1178 patients treated with free flap reconstructive surgery following ablation of HNSCC in a group of Italian tertiary hospitals, all members of the Head & Neck Group affiliated with the Italian Society of Microsurgery. According to many authors, free flap surgery for HNSCC seems to be a beneficial option for treatment even in terms of survival.
- Published
- 2014
5. [Precancerous oral lesions. Diagnostic and therapeutic protocol]
- Author
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Franco Berrino, Chiesa F, Carrassi A, Costa L, Pedroni C, Sala L, Spriano S, Squadrelli-Saraceno M, Tradati N, and Toma S
- Subjects
Humans ,Mouth Neoplasms ,Precancerous Conditions - Abstract
The NRC (National Research Council) task force on head and neck cancer issued this document to help clinicians involved in diagnosing and treating precancerous oral diseases. Chapter 1 includes definition, epidemiology, risk factors (alcohol, smoking, poor oral hygiene), WHO classification, clinical picture of leukoplakias, erythroplasia, lichen planus, as well as their natural history. Chapter 2 points out the clinical signs to be looked for in order to make a proper diagnosis and discusses biopsy techniques. Chapter 3 deals with therapeutic procedures (surgical technique and medical treatment), while Chapter 4 concerns follow-up according to the clinical and histological diagnosis. Finally, some statistical forms are enclosed: Form 1 consists of information regarding educational qualifications, occupation, alcohol consumption, smoking and dietary habits; Form 2 consists of information about previous diseases and the history of the present disease; Form 3 records the signs and symptoms observed for the precancerous lesion; Form 4 records treatment modalities; Form 5 records patient follow-up.
- Published
- 1989
6. Patients' survival after free flap reconstructive surgery of head and neck squamous cell carcinoma: A retrospective multicentre study,Sopravvivenza dopo chirurgia ricostruttiva con lembi liberi nel carcinoma spinocellulare del distretto cervico facciale: Studio retrospettivo multicentrico
- Author
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Salvatori, P., Paradisi, S., Calabrese, L., Zani, A., Cantù, G., Cappiello, J., Benazzo, M., Bozzetti, A., Bellocchi, G., Rinaldi Ceroni, A., Succo, G., Pastore, A., Chiesa, F., Riccio, S., Cesare PIAZZA, Ochini, A., Sozzi, D., Damiani, V., Caliceti, U., Crosetti, E., Pelucchi, S., Squadrelli Saraceno, M., and Podrecca, S.
7. In vivo interleukin 2-induced activation of lymphokine-activated killer cells and tumor cytotoxic T-cells in cervical lymph nodes of patients with head and neck tumors
- Author
-
Rivoltini, L., Gambacorti-Passerini, C., Squadrelli-Saraceno, M., Grosso, M. I., Cantu, G., Molinari, R., attilio orazi, and Parmiani, G.
8. Melanoma of the oral cavity: a case report.
- Author
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Lupatelli, M., Ficarra, G., and Squadrelli Saraceno, M.
- Published
- 2015
9. Sclerosing Paraganglioma of the Carotid Body: A Potential Pitfall of Malignancy
- Author
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Valeria Saladino, Gabriella Nesi, Raffaella Santi, Massimo Trovati, Giovanna Cenacchi, Massimo Squadrelli-Saraceno, Alessandro Franchi, Santi R, Franchi A, Saladino V, Trovati M, Cenacchi G, Squadrelli-Saraceno M, and Nesi G.
- Subjects
Adult ,Pathology ,medicine.medical_specialty ,Synaptophysin ,Case Report ,Head and neck paraganglioma ,Neuroendocrine tumors ,Malignancy ,Carotid Body Tumor ,Pathology and Forensic Medicine ,Lesion ,Paraganglioma ,Diagnosis, Differential ,Diagnosis ,medicine ,Chromogranins ,Carotid body tumour ,Sclerosing paraganglioma ,Female ,Head and Neck Neoplasms ,Humans ,Immunohistochemistry ,Magnetic Resonance Imaging ,Neuroendocrine Tumors ,Phosphopyruvate Hydratase ,Sclerosis ,2734 ,Otorhinolaryngology2734 Pathology and Forensic Medicine ,Oncology ,biology ,Chromogranin A ,Anatomy ,medicine.disease ,Otorhinolaryngology ,Pleomorphism (cytology) ,Differential ,biology.protein ,Differential diagnosis ,medicine.symptom - Abstract
Paragangliomas (PGs) of the head and neck region are typically benign, slow-growing neuroendocrine tumours. At times, they may exhibit unusual histological features, such as prominent stromal sclerosis (sclerosing PG), which may raise concerns of malignancy. We describe a case of sclerosing PG of the carotid body, emphasizing the value of immunohistochemical stains for differential diagnosis. A 43-year-old woman presented with a painless lump on the neck. A magnetic resonance imaging scan demonstrated a hypervascular lesion of the carotid body, which was surgically excised. Grossly, the lesion measured 1.8 cm at maximum diameter. On microscopic examination, irregular nests and tiny bundles of neoplastic cells were found between thick bands of fibrous tissue. Focal nuclear cytomegaly and marked pleomorphism were noted. Neoplastic cells proved to be immunoreactive for chromogranin, synaptophysin and neuron specific enolase, but negative for cytokeratins, smooth muscle actin and CD34. Ultrastructurally, numerous mitochondria, rough endoplasmic reticulum structures and endocrine granules were seen in the cytoplasm of the tumour cells. On consideration of the above-mentioned clinico-pathological and ultrastructural findings a diagnosis of sclerosing PG was established. Sclerosing PG is a rare entity which may mimic a malignant neoplasm. The recognition of this unusual morphological variant of PG, together with appropriate immunostains, leads to the correct diagnosis.
- Published
- 2014
10. Patients' survival after free flap reconstructive surgery of head and neck squamous cell carcinoma: a retrospective multicentre study
- Author
-
Salvatori, P., Paradisi, S., Calabrese, L., Zani, A., Cantu, G., Cappiello, J., Marco Benazzo, Bozzetti, A., Bellocchi, G., Ceroni, A. Rinaldi, Succo, G., Pastore, A., Chiesa, F., Riccio, S., Piazza, C., Ochini, A., Sozzi, D., Damiani, V., Caliceti, U., Crosetti, E., Pelucchi, S., Saraceno, M. Squadrelli, Podrecca, S., Salvatori, P, Paradisi, S, Calabrese, L, Zani, A, Cantù, G, Cappiello, J, Benazzo, M, Bozzetti, A, Bellocchi, G, Rinaldi Ceroni, A, Succo, G, Pastore, A, Chiesa, F, Riccio, S, Piazza, C, Occhini, A, Sozzi, D, Damiani, V, Caliceti, U, Crosetti, E, Pelucchi, S, Squadrelli Saraceno, M, and Podrecca, S
- Subjects
Adult ,Male ,MED/29 - CHIRURGIA MAXILLOFACCIALE ,Adolescent ,Survival ,MED/31 - OTORINOLARINGOIATRIA ,Free Tissue Flaps ,NO ,Young Adult ,Head and neck tumours ,Retrospective Studie ,Head and neck tumours, Free flap, Survival ,Reconstructive Surgical Procedure ,Humans ,MED/19 - CHIRURGIA PLASTICA ,Aged ,Retrospective Studies ,Free flap ,Aged, 80 and over ,Head and Neck Neoplasm ,Squamous Cell Carcinoma of Head and Neck ,Middle Aged ,Plastic Surgery Procedures ,Survival Rate ,Head and Neck Neoplasms ,Heand and Neck ,Carcinoma, Squamous Cell ,Head and neck tumour ,Female ,Human - Abstract
Head and neck squamous cell carcinoma of the (HNSCC) represents approximately 5% of malignant tumours in Italy. HNSCC are commonly treated with surgery or radiotherapy, or a combination of such therapies. The objectives of treatment are maximum cure rate balanced with organ preservation, restoration of form and function, reduction of morbidities and improvement or maintenance of the patient's quality of life. Immediate reconstructive surgery: local, regional or free flaps are now widely advised in the treatment of these patients. Microsurgical transfer requires expertise, is time and resource consuming, and as a whole requires substantial costs. These considerations introduce some concerns about the wide or indiscriminate use of free flap reconstructive surgery. When considering cost-benefit outcomes of such treatment, the main objective is undoubtedly, survival. This data is underreported in the current literature, whereas functional outcomes of free flaps have been largely diffused and accepted. This study collects data from 1178 patients treated with free flap reconstructive surgery following ablation of HNSCC in a group of Italian tertiary hospitals, all members of the HeadNeck Group affiliated with the Italian Society of Microsurgery. According to many authors, free flap surgery for HNSCC seems to be a beneficial option for treatment even in terms of survival.I tumori spinocellulari del distretto Cervico Facciale rappresentano circa il 5% dei tumori maligni in Italia. Essi sono comunemente trattati con chirurgia o radioterapia, o entrambi le terapie. La ricostruzione rappresenta un momento fondamentale della terapia nel rispetto della qualità di vita di questi pazienti. La microchirurgia ricostruttiva rappresenta la tecnica che offre i migliori risultati funzionali ma è oggetto di discussione in un rapporto costo-benefici. In questo lavoro sono raccolti ed analizzati i dati di 1178 pazienti provenienti dai membri del gruppo testa e collo, affiliato alla società Italiana di Microchirurgia, e i cui dati sono rapportati primariamente alla sopravvivenza.
- Published
- 2013
11. Masses of the Paranasal Sinuses After Treatment of Nasopharyngeal Carcinoma: A Case Report.
- Author
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Lazio MS, Cannavicci A, Squadrelli Saraceno M, and Maggiore G
- Abstract
The development of a new mass in the field of irradiation of a previously treated Nasopharyngeal carcinoma is generally considered a sign of recurrence. We report a case of a 46-year-old male, with a past history of undifferentiated NPC, with an expansive lesion discovered during radiological follow-up that occupied nasal cavity and paranasal sinuses. The endoscopic sinuses surgery was necessary in order to analyze and remove the mass with intraoperative frozen sections to highlight mucosa free from disease. The presence of non-malignant masses in the paranasal sinuses are rare complications after radiotherapy at the skull base, but represent an eventuality that must be considered in the differential diagnosis of a suspected recurrence or with a secondary malignancies after radiation therapy. It is therefore required a final diagnosis based on biopsy, follow-up and an eventual endoscopic surgical treatment., Competing Interests: Conflict of interestAll authors disclose any financial and personal relationships with other people or organizations that could influence the own work., (© Association of Otolaryngologists of India 2018.)
- Published
- 2019
- Full Text
- View/download PDF
12. Psychological distress and health-related quality of life among head and neck cancer patients during the first year after treatment.
- Author
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Ninu MB, Miccinesi G, Bulli F, De Massimi A, Muraca MG, Franchi G, and Squadrelli Saraceno M
- Subjects
- Adult, Aged, Appetite drug effects, Appetite radiation effects, Combined Modality Therapy, Constipation etiology, Deglutition Disorders etiology, Diarrhea etiology, Dyspnea etiology, Eating, Fatigue etiology, Female, Head and Neck Neoplasms complications, Head and Neck Neoplasms physiopathology, Health Status, Humans, Male, Middle Aged, Nausea etiology, Pain etiology, Self Report, Sexual Behavior drug effects, Sexual Behavior radiation effects, Sleep Initiation and Maintenance Disorders etiology, Speech Disorders etiology, Head and Neck Neoplasms psychology, Head and Neck Neoplasms therapy, Quality of Life, Stress, Psychological etiology
- Abstract
Purpose: Patients treated for head and neck cancer present some of the most significant posttreatment morbidity of any group of patients with cancer. Our aim is to describe quality of life and psychological distress after different treatments among head and neck cancer patients during the first year after treatment., Methods: A total of 86 patients treated for head and neck cancer were evaluated within 1 year of the end of treatment by means of the Distress Thermometer (DT) and EORTC C30 and H&N35 questionnaires. Type of treatment was classified into 3 groups: surgery, chemo-/radiotherapy, and combined treatment., Results: Forty-one percent of patients showed a high level of distress (DT >5). Distress was higher in patients with a tracheotomy or with previous cancer in another district. Quality of life was homogeneous across treatment types after adjustment for stage and time since end of treatment, except for higher levels of suffering related to sensory problems, social eating, and dry mouth among patients treated with combined therapy., Conclusions: The DT and EORTC questionnaires proved to be effective and easy tools to monitor distress and quality of life in patients with head and neck cancer. Monitoring the quality of life perceived by each patient during his/her course of treatment could be useful in planning the rehabilitation process while performing follow-up visits.
- Published
- 2016
- Full Text
- View/download PDF
13. Sclerosing paraganglioma of the carotid body: a potential pitfall of malignancy.
- Author
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Santi R, Franchi A, Saladino V, Trovati M, Cenacchi G, Squadrelli-Saraceno M, and Nesi G
- Subjects
- Adult, Carotid Body Tumor metabolism, Chromogranins metabolism, Diagnosis, Differential, Female, Head and Neck Neoplasms metabolism, Humans, Immunohistochemistry, Magnetic Resonance Imaging, Neuroendocrine Tumors metabolism, Phosphopyruvate Hydratase metabolism, Sclerosis diagnosis, Sclerosis metabolism, Sclerosis pathology, Synaptophysin metabolism, Carotid Body Tumor diagnosis, Carotid Body Tumor pathology, Head and Neck Neoplasms diagnosis, Head and Neck Neoplasms pathology, Neuroendocrine Tumors diagnosis, Neuroendocrine Tumors pathology
- Abstract
Paragangliomas (PGs) of the head and neck region are typically benign, slow-growing neuroendocrine tumours. At times, they may exhibit unusual histological features, such as prominent stromal sclerosis (sclerosing PG), which may raise concerns of malignancy. We describe a case of sclerosing PG of the carotid body, emphasizing the value of immunohistochemical stains for differential diagnosis. A 43-year-old woman presented with a painless lump on the neck. A magnetic resonance imaging scan demonstrated a hypervascular lesion of the carotid body, which was surgically excised. Grossly, the lesion measured 1.8 cm at maximum diameter. On microscopic examination, irregular nests and tiny bundles of neoplastic cells were found between thick bands of fibrous tissue. Focal nuclear cytomegaly and marked pleomorphism were noted. Neoplastic cells proved to be immunoreactive for chromogranin, synaptophysin and neuron specific enolase, but negative for cytokeratins, smooth muscle actin and CD34. Ultrastructurally, numerous mitochondria, rough endoplasmic reticulum structures and endocrine granules were seen in the cytoplasm of the tumour cells. On consideration of the above-mentioned clinico-pathological and ultrastructural findings a diagnosis of sclerosing PG was established. Sclerosing PG is a rare entity which may mimic a malignant neoplasm. The recognition of this unusual morphological variant of PG, together with appropriate immunostains, leads to the correct diagnosis.
- Published
- 2015
- Full Text
- View/download PDF
14. Patients' survival after free flap reconstructive surgery of head and neck squamous cell carcinoma: a retrospective multicentre study.
- Author
-
Salvatori P, Paradisi S, Calabrese L, Zani A, Cantù G, Cappiello J, Benazzo M, Bozzetti A, Bellocchi G, Rinaldi Ceroni A, Succo G, Pastore A, Chiesa F, Riccio S, Piazza C, Occhini A, Sozzi D, Damiani V, Caliceti U, Crosetti E, Pelucchi S, Squadrelli Saraceno M, and Podrecca S
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Plastic Surgery Procedures methods, Retrospective Studies, Squamous Cell Carcinoma of Head and Neck, Survival Rate, Young Adult, Carcinoma, Squamous Cell mortality, Carcinoma, Squamous Cell surgery, Free Tissue Flaps, Head and Neck Neoplasms mortality, Head and Neck Neoplasms surgery
- Abstract
Head and neck squamous cell carcinoma of the (HNSCC) represents approximately 5% of malignant tumours in Italy. HNSCC are commonly treated with surgery or radiotherapy, or a combination of such therapies. The objectives of treatment are maximum cure rate balanced with organ preservation, restoration of form and function, reduction of morbidities and improvement or maintenance of the patient's quality of life. Immediate reconstructive surgery: local, regional or free flaps are now widely advised in the treatment of these patients. Microsurgical transfer requires expertise, is time and resource consuming, and as a whole requires substantial costs. These considerations introduce some concerns about the wide or indiscriminate use of free flap reconstructive surgery. When considering cost-benefit outcomes of such treatment, the main objective is undoubtedly, survival. This data is underreported in the current literature, whereas functional outcomes of free flaps have been largely diffused and accepted. This study collects data from 1178 patients treated with free flap reconstructive surgery following ablation of HNSCC in a group of Italian tertiary hospitals, all members of the Head & Neck Group affiliated with the Italian Society of Microsurgery. According to many authors, free flap surgery for HNSCC seems to be a beneficial option for treatment even in terms of survival.
- Published
- 2014
15. Autonomous reparative unit (ARU): a new concept of repairing free flap donor site with local full-thickness skin graft.
- Author
-
Squadrelli-Saraceno M, Compan A, Bimbi G, Gatto L, Riccio S, and Colombo S
- Subjects
- Follow-Up Studies, Humans, Mouth Neoplasms surgery, Oropharyngeal Neoplasms surgery, Skin Transplantation methods, Surgical Flaps, Tissue and Organ Harvesting
- Abstract
Usually, harvesting free flap in the limbs creates an inevitable sequence of aesthetic damage not only in the donor site but also in the area of the graft used to repair the free flap donor site. Aim of the study was to standardize a simple method, defined Autonomous Reparative Unit, that allows closing of the donor site defects with a skin graft from the adjacent cutaneous area, avoiding further aesthetic damage in a third area. We define the "Autonomous Reparative Unit" as the rectangular shaped skin area of the flap and the dermoepidermic skin graft designed as an isoscele triangle with the base adjacent to the smaller side of the flap defect. From 2003 to 2008, at the Fondazione IRCCS Istituto Nationale Tumori of Milan, 143 free radial forearm flaps and 42 free osteofasciocutaneous fibula flaps have been performed for head and neck cancer. The autonomous reparative unit has been applicable in 177 cases (92.1%). The autonomous reparative unit method allows a "standard"primary reconstructive unit to be created which can be used in a single or in multiple ways thus avoiding an additional surgical scar and a subsequent additional aesthetic impairment.
- Published
- 2010
16. Review of 346 patients with free-flap reconstruction following head and neck surgery for neoplasm.
- Author
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Podrecca S, Salvatori P, Squadrelli Saraceno M, Fallahdar D, Calabrese L, Cantù G, and Molinari R
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell secondary, Carcinoma, Squamous Cell surgery, Child, Esthetics, Female, Head and Neck Neoplasms pathology, Hospital Mortality, Humans, Male, Microsurgery methods, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Plastic Surgery Procedures adverse effects, Reoperation, Survival Rate, Treatment Outcome, Head and Neck Neoplasms surgery, Plastic Surgery Procedures methods, Surgical Flaps
- Abstract
We present our 14-year experience of free tissue transfer following surgery for head and neck neoplasm. We evaluated 346 patients mean age 57 years, 65% had squamous cell carcinoma; the most frequent sites were oral cavity and mandible (168) craniomaxillo facial region (94) pharynx +/- cervical oesophagus and oropharyngostomes (84). In 327 (95%) cases the reconstruction was a success. Flap revision was necessary in 29 (8.4% of total) and recovery was successful in 10/29. Nine patients (2.6%) died perioperatively. Poor preoperative condition, previous treatment, and requirement for vein graft were significantly associated with increased risk of major complications after surgery. Cosmetic and functional outcomes were assessed on 1-10 scales: 69 and 77% of patients, respectively, had cosmetic and functional results in the 7-10 range, indicating successful outcome. Overall survival probabilities, estimated on 338 patients with malignant disease, were 53% at 2 years and 32% at 5 years. Most patients, but not all, had advanced disease stage, and 188 (54%) had recurrent disease. Hence, overall survival rates are acceptable and justify the use of complex reconstruction procedures in such patients.
- Published
- 2006
- Full Text
- View/download PDF
17. Which classification for ethmoid malignant tumors involving the anterior skull base?
- Author
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Cantù G, Solero CL, Miceli R, Mariani L, Mattavelli F, Squadrelli-Saraceno M, Bimbi G, Riccio S, Colombo S, Locati L, Olmi P, and Licitra L
- Subjects
- Adolescent, Adult, Aged, Child, Disease-Free Survival, Female, Humans, Male, Middle Aged, Nasal Cavity pathology, Neoplasm Invasiveness, Paranasal Sinus Neoplasms surgery, Prognosis, Cranial Fossa, Anterior pathology, Ethmoid Sinus, Neoplasm Staging classification, Paranasal Sinus Neoplasms classification, Paranasal Sinus Neoplasms pathology
- Abstract
Background: The purpose of this study was to compare three systems of classification for malignant ethmoidal tumors in patients undergoing anterior craniofacial resection., Methods: A radiologic locoregional evaluation of 241 patients with malignant ethmoid tumors was performed before patients underwent an anterior craniofacial resection. Disease in each case was staged according to the American Joint Committee on Cancer-Union Internationale Contre le Cancer (AJCC-UICC) 1997 classification, the AJCC-UICC 2002 classification, and the Istituto Nazionale Tumori (INT) classification. Kaplan-Meier curves and Cox models were used to investigate the prognostic value of each classification system on disease-free survival (DFS) and overall survival (OS). The classifications were compared in terms of prognostic discrimination capability, measured by use of an index of agreement between each classification and DFS or OS time., Results: All three classification systems yielded statistically significant results in the Cox analysis, both for DFS and OS. In the AJCC-UICC 2002 system, minor differences were observed between T1 and T3 tumors. The INT classification showed a progressive worsening of the prognosis with increasing stage. The index of prognostic discrimination favored the INT classification over both the 1997 and 2002 AJCC-UICC classifications., Conclusions: Both the 1997 and 2002 AJCC-UICC classifications seemed to have limited prognostic value. By contrast, the INT classification satisfied one of the main goals of tumor staging, demonstrating the progressive worsening of prognosis with different tumor classes., (2004 Wiley Periodicals, Inc.)
- Published
- 2005
- Full Text
- View/download PDF
18. Local adoptive immunotherapy of advanced head and neck tumors with LAK cells and interleukin-2.
- Author
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Squadrelli-Saraceno M, Rivoltini L, Cantù G, Ravagnani F, Parmiani G, and Molinari R
- Subjects
- Aged, Aged, 80 and over, Female, Humans, Lymphatic Metastasis, Male, Middle Aged, Remission Induction, Head and Neck Neoplasms therapy, Immunotherapy, Interleukin-2 therapeutic use, Killer Cells, Lymphokine-Activated
- Abstract
Since October 1987 a pilot phase I-II study on the effect of loco-regional injections of recombinant interleukin 2 (rIL-2) in association with LAK cells has been performed in advanced, recurrent head and neck cancer patients. Fourteen patients were treated with autologous LAKs and rIL-2 (Glaxo) given peritumorally and in the mastoid region (rIL-2 only in the latter site). LAKs (2-70 x 10(7)) + rIL-2 were injected on the first day of therapy, followed by 9 daily injections of rIL-2 only. The total daily dose of rIL-2 was escalated from 2,400 to 1.8 x 10(6) IU. Clinical evaluation was performed 30 days from the onset of therapy; 3 partial (95%, 66% and 50% reduction) and 3 minor responses were seen in the evaluated patients. All the other patients with a progressive disease after the first cycle were shifted to palliative chemotherapy. The partial responses were found in patients with a tumor burden less than 20 cm2. Cervical node metastasis did not respond to treatment. No relevant side effects occurred. These results indicate that loco-regional immunotherapy with rIL-2 and LAK cells can produce clinical responses in advanced head and neck cancer patients.
- Published
- 1990
- Full Text
- View/download PDF
19. In vivo interleukin 2-induced activation of lymphokine-activated killer cells and tumor cytotoxic T-cells in cervical lymph nodes of patients with head and neck tumors.
- Author
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Rivoltini L, Gambacorti-Passerini C, Squadrelli-Saraceno M, Grosso MI, Cantù G, Molinari R, Orazi A, and Parmiani G
- Subjects
- Aged, Antigens, CD analysis, Cell Line, Combined Modality Therapy, Cytotoxicity, Immunologic, Female, Head and Neck Neoplasms drug therapy, Head and Neck Neoplasms pathology, Head and Neck Neoplasms surgery, Humans, Killer Cells, Lymphokine-Activated drug effects, Lymph Nodes pathology, Lymph Nodes surgery, Male, Middle Aged, Recombinant Proteins therapeutic use, T-Lymphocytes, Cytotoxic drug effects, Head and Neck Neoplasms immunology, Interleukin-2 therapeutic use, Killer Cells, Lymphokine-Activated immunology, Lymph Nodes immunology, T-Lymphocytes, Cytotoxic immunology
- Abstract
To study whether regional injection of recombinant interleukin 2 (rIL-2) can induce an in vivo lymphocyte activation in cervical lymph nodes (LNs) of patients with head and neck carcinoma, 12 patients, candidates for prophylactic dissection, were treated for 7-10 days prior to surgery with rIL-2, 10(5) units/day, injected in the perimastoid region. A marked induction of cytotoxic activity against allogeneic (K562 and Daudi lines) and autologous target cells (fresh spindle cell carcinomas of the tongue) was observed in lymphocytes obtained from jugular, spinal, and, to a lesser extent, submandibular LNs of all treated patients. An increase of cytotoxicity was also present in LNs contralateral to the rIL-2 injection side. On the other hand, only a borderline increase in spontaneous proliferation was detected. Moreover, in the two cases tested, a marked and apparently autologous tumor (Auto-Tu)-specific lysis was found in CD5+ lymphocytes obtained from LNs, whereas lymphokine-activated killer activity was mainly exerted by CD16+ natural killer cells. T-lymphocytes, when cultured with irradiated Auto-Tu cells and low doses of rIL-2, showed an increased Auto-Tu lysis, while cytotoxicity against allogeneic tumor cells (including K562) was not observed. These data indicate that regional injection of rIL-2 can activate lymphokine-activated killer cells from LN lymphocytes but also induce and/or expand a T-cell population expressing a restricted Auto-Tu cytotoxicity.
- Published
- 1990
20. [Precancerous oral lesions. Diagnostic and therapeutic protocol].
- Author
-
Berrino F, Chiesa F, Carrassi A, Costa L, Pedroni C, Sala L, Spriano S, Squadrelli-Saraceno M, Tradati N, and Toma S
- Subjects
- Humans, Mouth Neoplasms diagnosis, Mouth Neoplasms therapy, Mouth Neoplasms etiology, Precancerous Conditions diagnosis, Precancerous Conditions therapy
- Abstract
The NRC (National Research Council) task force on head and neck cancer issued this document to help clinicians involved in diagnosing and treating precancerous oral diseases. Chapter 1 includes definition, epidemiology, risk factors (alcohol, smoking, poor oral hygiene), WHO classification, clinical picture of leukoplakias, erythroplasia, lichen planus, as well as their natural history. Chapter 2 points out the clinical signs to be looked for in order to make a proper diagnosis and discusses biopsy techniques. Chapter 3 deals with therapeutic procedures (surgical technique and medical treatment), while Chapter 4 concerns follow-up according to the clinical and histological diagnosis. Finally, some statistical forms are enclosed: Form 1 consists of information regarding educational qualifications, occupation, alcohol consumption, smoking and dietary habits; Form 2 consists of information about previous diseases and the history of the present disease; Form 3 records the signs and symptoms observed for the precancerous lesion; Form 4 records treatment modalities; Form 5 records patient follow-up.
- Published
- 1989
21. [Diagnostic delay in neoplasms of the oral cavity and oropharynx].
- Author
-
Squadrelli-Saraceno M, Sant M, Chiesa F, Spriano G, Cifola M, Marchetti C, Piffer S, Claudio F, Grosso MI, and Pedroni C
- Subjects
- Aged, Female, Humans, Male, Middle Aged, Mouth Neoplasms etiology, Multicenter Studies as Topic, Oropharyngeal Neoplasms etiology, Probability, Risk Factors, Time Factors, Mouth Neoplasms diagnosis, Oropharyngeal Neoplasms diagnosis, Pharyngeal Neoplasms diagnosis
- Published
- 1988
22. [Evaluation of the respiratory function and rehabilitation after laryngectomy].
- Author
-
Squadrelli-Saraceno M, Costa L, Chiesa F, and Molinari R
- Subjects
- Aged, Female, Humans, Male, Middle Aged, Pilot Projects, Plethysmography, Respiratory Function Tests, Exercise Therapy, Laryngectomy rehabilitation, Respiration
- Published
- 1988
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