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1. Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2

Author

Moffitt, Andrea B, Ondrejka, Sarah L, McKinney, Matthew, Rempel, Rachel E, Goodlad, John R, Teh, Chun Huat, Leppa, Sirpa, Mannisto, Susanna, Kovanen, Panu E, Tse, Eric, Au-Yeung, Rex KH, Kwong, Yok-Lam, Srivastava, Gopesh, Iqbal, Javeed, Yu, Jiayu, Naresh, Kikkeri, Villa, Diego, Gascoyne, Randy D, Said, Jonathan, Czader, Magdalena B, Chadburn, Amy, Richards, Kristy L, Rajagopalan, Deepthi, Davis, Nicholas S, Smith, Eileen C, Palus, Brooke C, Tzeng, Tiffany J, Healy, Jane A, Lugar, Patricia L, Datta, Jyotishka, Love, Cassandra, Levy, Shawn, Dunson, David B, Zhuang, Yuan, Hsi, Eric D, and Dave, Sandeep S

Subjects
Genetics, Cancer, Hematology, Lymphoma, Rare Diseases, Clinical Research, Biotechnology, Digestive Diseases, 2.1 Biological and endogenous factors, Aetiology, Animals, DNA Copy Number Variations, Enteropathy-Associated T-Cell Lymphoma, Female, Gene Expression Profiling, Gene Silencing, Histone-Lysine N-Methyltransferase, Humans, Male, Mice, Knockout, Middle Aged, Mutation, Sequence Analysis, DNA, T-Lymphocytes, Medical and Health Sciences, Immunology
Abstract

Enteropathy-associated T cell lymphoma (EATL) is a lethal, and the most common, neoplastic complication of celiac disease. Here, we defined the genetic landscape of EATL through whole-exome sequencing of 69 EATL tumors. SETD2 was the most frequently silenced gene in EATL (32% of cases). The JAK-STAT pathway was the most frequently mutated pathway, with frequent mutations in STAT5B as well as JAK1, JAK3, STAT3, and SOCS1 We also identified mutations in KRAS, TP53, and TERT Type I EATL and type II EATL (monomorphic epitheliotropic intestinal T cell lymphoma) had highly overlapping genetic alterations indicating shared mechanisms underlying their pathogenesis. We modeled the effects of SETD2 loss in vivo by developing a T cell-specific knockout mouse. These mice manifested an expansion of γδ T cells, indicating novel roles for SETD2 in T cell development and lymphomagenesis. Our data render the most comprehensive genetic portrait yet of this uncommon but lethal disease and may inform future classification schemes.

Published
2017

2. Data from The Genetic Basis of Hepatosplenic T-cell Lymphoma

Author

McKinney, Matthew, primary, Moffitt, Andrea B., primary, Gaulard, Philippe, primary, Travert, Marion, primary, De Leval, Laurence, primary, Nicolae, Alina, primary, Raffeld, Mark, primary, Jaffe, Elaine S., primary, Pittaluga, Stefania, primary, Xi, Liqiang, primary, Heavican, Tayla, primary, Iqbal, Javeed, primary, Belhadj, Karim, primary, Delfau-Larue, Marie Helene, primary, Fataccioli, Virginie, primary, Czader, Magdalena B., primary, Lossos, Izidore S., primary, Chapman-Fredricks, Jennifer R., primary, Richards, Kristy L., primary, Fedoriw, Yuri, primary, Ondrejka, Sarah L., primary, Hsi, Eric D., primary, Low, Lawrence, primary, Weisenburger, Dennis, primary, Chan, Wing C., primary, Mehta-Shah, Neha, primary, Horwitz, Steven, primary, Bernal-Mizrachi, Leon, primary, Flowers, Christopher R., primary, Beaven, Anne W., primary, Parihar, Mayur, primary, Baseggio, Lucile, primary, Parrens, Marie, primary, Moreau, Anne, primary, Sujobert, Pierre, primary, Pilichowska, Monika, primary, Evens, Andrew M., primary, Chadburn, Amy, primary, Au-Yeung, Rex K.H., primary, Srivastava, Gopesh, primary, Choi, William W. L., primary, Goodlad, John R., primary, Aurer, Igor, primary, Basic-Kinda, Sandra, primary, Gascoyne, Randy D., primary, Davis, Nicholas S., primary, Li, Guojie, primary, Zhang, Jenny, primary, Rajagopalan, Deepthi, primary, Reddy, Anupama, primary, Love, Cassandra, primary, Levy, Shawn, primary, Zhuang, Yuan, primary, Datta, Jyotishka, primary, Dunson, David B., primary, and Davé, Sandeep S., primary

Published
2023
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3. Data from Monochromosome Transfer and Microarray Analysis Identify a Critical Tumor-Suppressive Region Mapping to Chromosome 13q14 and THSD1 in Esophageal Carcinoma

Author

Ko, Josephine M.Y., primary, Chan, Pui Ling, primary, Yau, Wing Lung, primary, Chan, Ho Kin, primary, Chan, King Chi, primary, Yu, Zhuo You, primary, Kwong, Fung Mei, primary, Miller, Lance D., primary, Liu, Edison T., primary, Yang, Li Chun, primary, Lo, Paulisally H.Y., primary, Stanbridge, Eric J., primary, Tang, Johnny C.O., primary, Srivastava, Gopesh, primary, Tsao, Sai Wah, primary, Law, Simon, primary, and Lung, Maria L., primary

Published
2023
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4. Supplementary Tables S1 - S10 from The Genetic Basis of Hepatosplenic T-cell Lymphoma

Author

McKinney, Matthew, primary, Moffitt, Andrea B., primary, Gaulard, Philippe, primary, Travert, Marion, primary, De Leval, Laurence, primary, Nicolae, Alina, primary, Raffeld, Mark, primary, Jaffe, Elaine S., primary, Pittaluga, Stefania, primary, Xi, Liqiang, primary, Heavican, Tayla, primary, Iqbal, Javeed, primary, Belhadj, Karim, primary, Delfau-Larue, Marie Helene, primary, Fataccioli, Virginie, primary, Czader, Magdalena B., primary, Lossos, Izidore S., primary, Chapman-Fredricks, Jennifer R., primary, Richards, Kristy L., primary, Fedoriw, Yuri, primary, Ondrejka, Sarah L., primary, Hsi, Eric D., primary, Low, Lawrence, primary, Weisenburger, Dennis, primary, Chan, Wing C., primary, Mehta-Shah, Neha, primary, Horwitz, Steven, primary, Bernal-Mizrachi, Leon, primary, Flowers, Christopher R., primary, Beaven, Anne W., primary, Parihar, Mayur, primary, Baseggio, Lucile, primary, Parrens, Marie, primary, Moreau, Anne, primary, Sujobert, Pierre, primary, Pilichowska, Monika, primary, Evens, Andrew M., primary, Chadburn, Amy, primary, Au-Yeung, Rex K.H., primary, Srivastava, Gopesh, primary, Choi, William W. L., primary, Goodlad, John R., primary, Aurer, Igor, primary, Basic-Kinda, Sandra, primary, Gascoyne, Randy D., primary, Davis, Nicholas S., primary, Li, Guojie, primary, Zhang, Jenny, primary, Rajagopalan, Deepthi, primary, Reddy, Anupama, primary, Love, Cassandra, primary, Levy, Shawn, primary, Zhuang, Yuan, primary, Datta, Jyotishka, primary, Dunson, David B., primary, and Davé, Sandeep S., primary

Published
2023
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5. Supplementary Methods, Figures S1 - S9 from The Genetic Basis of Hepatosplenic T-cell Lymphoma

Author

McKinney, Matthew, primary, Moffitt, Andrea B., primary, Gaulard, Philippe, primary, Travert, Marion, primary, De Leval, Laurence, primary, Nicolae, Alina, primary, Raffeld, Mark, primary, Jaffe, Elaine S., primary, Pittaluga, Stefania, primary, Xi, Liqiang, primary, Heavican, Tayla, primary, Iqbal, Javeed, primary, Belhadj, Karim, primary, Delfau-Larue, Marie Helene, primary, Fataccioli, Virginie, primary, Czader, Magdalena B., primary, Lossos, Izidore S., primary, Chapman-Fredricks, Jennifer R., primary, Richards, Kristy L., primary, Fedoriw, Yuri, primary, Ondrejka, Sarah L., primary, Hsi, Eric D., primary, Low, Lawrence, primary, Weisenburger, Dennis, primary, Chan, Wing C., primary, Mehta-Shah, Neha, primary, Horwitz, Steven, primary, Bernal-Mizrachi, Leon, primary, Flowers, Christopher R., primary, Beaven, Anne W., primary, Parihar, Mayur, primary, Baseggio, Lucile, primary, Parrens, Marie, primary, Moreau, Anne, primary, Sujobert, Pierre, primary, Pilichowska, Monika, primary, Evens, Andrew M., primary, Chadburn, Amy, primary, Au-Yeung, Rex K.H., primary, Srivastava, Gopesh, primary, Choi, William W. L., primary, Goodlad, John R., primary, Aurer, Igor, primary, Basic-Kinda, Sandra, primary, Gascoyne, Randy D., primary, Davis, Nicholas S., primary, Li, Guojie, primary, Zhang, Jenny, primary, Rajagopalan, Deepthi, primary, Reddy, Anupama, primary, Love, Cassandra, primary, Levy, Shawn, primary, Zhuang, Yuan, primary, Datta, Jyotishka, primary, Dunson, David B., primary, and Davé, Sandeep S., primary

Published
2023
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6. Supplementary Figures S1-S3 from Monochromosome Transfer and Microarray Analysis Identify a Critical Tumor-Suppressive Region Mapping to Chromosome 13q14 and THSD1 in Esophageal Carcinoma

Author

Ko, Josephine M.Y., primary, Chan, Pui Ling, primary, Yau, Wing Lung, primary, Chan, Ho Kin, primary, Chan, King Chi, primary, Yu, Zhuo You, primary, Kwong, Fung Mei, primary, Miller, Lance D., primary, Liu, Edison T., primary, Yang, Li Chun, primary, Lo, Paulisally H.Y., primary, Stanbridge, Eric J., primary, Tang, Johnny C.O., primary, Srivastava, Gopesh, primary, Tsao, Sai Wah, primary, Law, Simon, primary, and Lung, Maria L., primary

Published
2023
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7. Data from A20, ABIN-1/2, and CARD11 Mutations and Their Prognostic Value in Gastrointestinal Diffuse Large B-Cell Lymphoma

Author

Dong, Gehong, primary, Chanudet, Estelle, primary, Zeng, Naiyan, primary, Appert, Alex, primary, Chen, Yun-Wen, primary, Au, Wing-Yan, primary, Hamoudi, Rifat A., primary, Watkins, A. James, primary, Ye, Hongtao, primary, Liu, Hongxiang, primary, Gao, Zifen, primary, Chuang, Shih-Sung, primary, Srivastava, Gopesh, primary, and Du, Ming-Qing, primary

Published
2023
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8. Supplementary Data from A20, ABIN-1/2, and CARD11 Mutations and Their Prognostic Value in Gastrointestinal Diffuse Large B-Cell Lymphoma

Author

Dong, Gehong, primary, Chanudet, Estelle, primary, Zeng, Naiyan, primary, Appert, Alex, primary, Chen, Yun-Wen, primary, Au, Wing-Yan, primary, Hamoudi, Rifat A., primary, Watkins, A. James, primary, Ye, Hongtao, primary, Liu, Hongxiang, primary, Gao, Zifen, primary, Chuang, Shih-Sung, primary, Srivastava, Gopesh, primary, and Du, Ming-Qing, primary

Published
2023
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9. Data from KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas

Author

Cheng, Yingduan, primary, Geng, Hua, primary, Cheng, Suk Hang, primary, Liang, Pei, primary, Bai, Yan, primary, Li, Jisheng, primary, Srivastava, Gopesh, primary, Ng, Margaret H.L., primary, Fukagawa, Tatsuo, primary, Wu, Xiushan, primary, Chan, Anthony T.C., primary, and Tao, Qian, primary

Published
2023
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10. Supplementary Figure 1 from CMTM3, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Tumor Cell Growth through Inducing Apoptosis

Author

Wang, Yu, primary, Li, Jisheng, primary, Cui, Yan, primary, Li, Ting, primary, Ng, Ka Man, primary, Geng, Hua, primary, Li, Henan, primary, Shu, Xing-sheng, primary, Li, Hongyu, primary, Liu, Wei, primary, Luo, Bing, primary, Zhang, Qian, primary, Mok, Tony Shu Kam, primary, Zheng, Wei, primary, Qiu, Xiaoyan, primary, Srivastava, Gopesh, primary, Yu, Jun, primary, Sung, Joseph J.Y., primary, Chan, Anthony T.C., primary, Ma, Dalong, primary, Tao, Qian, primary, and Han, Wenling, primary

Published
2023
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11. Data from CMTM3, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Tumor Cell Growth through Inducing Apoptosis

Author

Wang, Yu, primary, Li, Jisheng, primary, Cui, Yan, primary, Li, Ting, primary, Ng, Ka Man, primary, Geng, Hua, primary, Li, Henan, primary, Shu, Xing-sheng, primary, Li, Hongyu, primary, Liu, Wei, primary, Luo, Bing, primary, Zhang, Qian, primary, Mok, Tony Shu Kam, primary, Zheng, Wei, primary, Qiu, Xiaoyan, primary, Srivastava, Gopesh, primary, Yu, Jun, primary, Sung, Joseph J.Y., primary, Chan, Anthony T.C., primary, Ma, Dalong, primary, Tao, Qian, primary, and Han, Wenling, primary

Published
2023
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12. Data from Extracellular Protease ADAMTS9 Suppresses Esophageal and Nasopharyngeal Carcinoma Tumor Formation by Inhibiting Angiogenesis

Author

Lo, Paulisally Hau Yi, primary, Lung, Hong Lok, primary, Cheung, Arthur Kwok Leung, primary, Apte, Suneel S., primary, Chan, Kwok Wah, primary, Kwong, Fung Mei, primary, Ko, Josephine Mun Yee, primary, Cheng, Yue, primary, Law, Simon, primary, Srivastava, Gopesh, primary, Zabarovsky, Eugene R., primary, Tsao, Sai Wah, primary, Tang, Johnny Cheuk On, primary, Stanbridge, Eric J., primary, and Lung, Maria Li, primary

Published
2023
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13. Supplementary Table 1 from Extracellular Protease ADAMTS9 Suppresses Esophageal and Nasopharyngeal Carcinoma Tumor Formation by Inhibiting Angiogenesis

Author

Lo, Paulisally Hau Yi, primary, Lung, Hong Lok, primary, Cheung, Arthur Kwok Leung, primary, Apte, Suneel S., primary, Chan, Kwok Wah, primary, Kwong, Fung Mei, primary, Ko, Josephine Mun Yee, primary, Cheng, Yue, primary, Law, Simon, primary, Srivastava, Gopesh, primary, Zabarovsky, Eugene R., primary, Tsao, Sai Wah, primary, Tang, Johnny Cheuk On, primary, Stanbridge, Eric J., primary, and Lung, Maria Li, primary

Published
2023
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14. Supplementary Figures Legends 1-3 from CMTM3, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Tumor Cell Growth through Inducing Apoptosis

Author

Wang, Yu, primary, Li, Jisheng, primary, Cui, Yan, primary, Li, Ting, primary, Ng, Ka Man, primary, Geng, Hua, primary, Li, Henan, primary, Shu, Xing-sheng, primary, Li, Hongyu, primary, Liu, Wei, primary, Luo, Bing, primary, Zhang, Qian, primary, Mok, Tony Shu Kam, primary, Zheng, Wei, primary, Qiu, Xiaoyan, primary, Srivastava, Gopesh, primary, Yu, Jun, primary, Sung, Joseph J.Y., primary, Chan, Anthony T.C., primary, Ma, Dalong, primary, Tao, Qian, primary, and Han, Wenling, primary

Published
2023
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15. Supplementary Figure 3 from CMTM3, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Tumor Cell Growth through Inducing Apoptosis

Author

Wang, Yu, primary, Li, Jisheng, primary, Cui, Yan, primary, Li, Ting, primary, Ng, Ka Man, primary, Geng, Hua, primary, Li, Henan, primary, Shu, Xing-sheng, primary, Li, Hongyu, primary, Liu, Wei, primary, Luo, Bing, primary, Zhang, Qian, primary, Mok, Tony Shu Kam, primary, Zheng, Wei, primary, Qiu, Xiaoyan, primary, Srivastava, Gopesh, primary, Yu, Jun, primary, Sung, Joseph J.Y., primary, Chan, Anthony T.C., primary, Ma, Dalong, primary, Tao, Qian, primary, and Han, Wenling, primary

Published
2023
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16. Supplementary Figure 2 from CMTM3, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Tumor Cell Growth through Inducing Apoptosis

Author

Wang, Yu, primary, Li, Jisheng, primary, Cui, Yan, primary, Li, Ting, primary, Ng, Ka Man, primary, Geng, Hua, primary, Li, Henan, primary, Shu, Xing-sheng, primary, Li, Hongyu, primary, Liu, Wei, primary, Luo, Bing, primary, Zhang, Qian, primary, Mok, Tony Shu Kam, primary, Zheng, Wei, primary, Qiu, Xiaoyan, primary, Srivastava, Gopesh, primary, Yu, Jun, primary, Sung, Joseph J.Y., primary, Chan, Anthony T.C., primary, Ma, Dalong, primary, Tao, Qian, primary, and Han, Wenling, primary

Published
2023
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17. Supplementary Table 1 from KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas

Author

Cheng, Yingduan, primary, Geng, Hua, primary, Cheng, Suk Hang, primary, Liang, Pei, primary, Bai, Yan, primary, Li, Jisheng, primary, Srivastava, Gopesh, primary, Ng, Margaret H.L., primary, Fukagawa, Tatsuo, primary, Wu, Xiushan, primary, Chan, Anthony T.C., primary, and Tao, Qian, primary

Published
2023
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20. Genetic heterogeneity of diffuse large B-cell lymphoma

Author

Zhang, Jenny, Grubor, Vladimir, Love, Cassandra L., Banerjee, Anjishnu, Richards, Kristy L., Mieczkowski, Piotr A., Dunphy, Cherie, Choi, William, Au, Wing Yan, Srivastava, Gopesh, Lugar, Patricia L, Rizzieri, David A., Lagoo, Anand S., Bernal-Mizrachi, Leon, Mann, Karen P., Flowers, Christopher, Naresh, Kikkeri, Evens, Andrew, Gordon, Leo I., Czader, Magdalena, Gill, Javed I., Hsi, Eric D., Liu, Qingquan, Fan, Alice, Walsh, Katherine, Jima, Dereje, Smith, Lisa L., Johnson, Amy J., Byrd, John C., Luftig, Micah A., Ni, Ting, Zhu, Jun, Chadburn, Amy, Levy, Shawn, Dunson, David, and Dave, Sandeep S.

Published
2013

25. Epigenomic characterization of a p53-regulated 3p22.2 tumor suppressor that inhibits STAT3 phosphorylation via protein docking and is frequently methylated in esophageal and other carcinomas: Erratum

Author

Li, Lili, primary, Xu, Juan, additional, Qiu, Guohua, additional, Ying, Jianming, additional, Du, Zhenfang, additional, Xiang, Tingxiu, additional, Wong, Kai Yau, additional, Srivastava, Gopesh, additional, Zhu, Xiao-Feng, additional, Mok, Tony S, additional, Chan, Anthony TC, additional, Chan, Francis KL, additional, Ambinder, Richard F, additional, and Tao, Qian, additional

Published
2022
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26. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs

Author

Jima, Dereje D., Zhang, Jenny, Jacobs, Cassandra, Richards, Kristy L., Dunphy, Cherie H., Choi, William W.L., Yan Au, Wing, Srivastava, Gopesh, Czader, Magdalena B., Rizzieri, David A., Lagoo, Anand S., Lugar, Patricia L., Mann, Karen P., Flowers, Christopher R., Bernal-Mizrachi, Leon, Naresh, Kikkeri N., Evens, Andrew M., Gordon, Leo I., Luftig, Micah, Friedman, Daphne R., Weinberg, J. Brice, Thompson, Michael A., Gill, Javed I., Liu, Qingquan, How, Tam, Grubor, Vladimir, Gao, Yuan, Patel, Amee, Wu, Han, Zhu, Jun, Blobe, Gerard C., Lipsky, Peter E., Chadburn, Amy, and Dave, Sandeep S.

Published
2010
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31. The genetic landscape of immune-competent and HIV lymphoma

Author

Zhang Jenny, Grubor Vladimir, Love Cassandra L, Banerjee Anjishnu, Richards Kristy L, Miezcowski Piotr, Dunphy Cherie H, Choi William WL, Auv Wing-Yan, Srivastava Gopesh, Lugar Patricia L, Rizzieri David A, Lagoo Anand S, Bernal-Mizrachi Leon, Mann Karen P, Flowers Christopher R, Naresh Kikkeri N, Evens Andrew M, Gordon Leo I, Czader Magdalena B, Gill Javed I, Hsi Eric D, Liu Qingquan, Fan Alice, Walsh Katherine, Jima Dereje D, Luftig Micah, Ni Ting, Zhu Jun, Chadburn Amy, Levy Shawn, Dunson David B, and Dave Sandeep S

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Infectious and parasitic diseases, RC109-216
Published
2012
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32. Upregulation of twist in oesophageal squamous cell carcinoma is associated with neoplastic transformation and distant metastasis

Author

Yuen, Hiu-Fung, Chan, Yuen-Piu, Wong, Michelle Lok-Yee, Kwok, Wei-Kei, Chan, Ka-Kui, Lee, Pin-Yin, Srivastava, Gopesh, Law, Simon Ying-Kit, Wong, Yong-Chuan, Wang, Xianghong, and Chan, Kwok-Wah

Subjects
DNA binding proteins -- Research, Esophageal cancer -- Development and progression, Esophageal cancer -- Complications and side effects, Esophageal cancer -- Research, Neoplastic processes -- Research, Metastasis -- Research, Health
Published
2007

47. Epigenetic silencing of the 3p22 tumor suppressor DLEC1 by promoter CpG methylation in non-Hodgkin and Hodgkin lymphomas

Author

Wang Zhaohui, Li Lili, Su Xianwei, Gao Zifen, Srivastava Gopesh, Murray Paul G, Ambinder Richard, and Tao Qian

Subjects
DLEC1, CpG, Methylation, Tumor suppressor, Lymphoma, Medicine
Abstract

Abstract Background Inactivaion of tumor suppressor genes (TSGs) by promoter CpG methylation frequently occurs in tumorigenesis, even in the early stages, contributing to the initiation and progression of human cancers. Deleted in lung and esophageal cancer 1 (DLEC1), located at the 3p22-21.3 TSG cluster, has been identified frequently silenced by promoter CpG methylation in multiple carcinomas, however, no study has been performed for lymphomas yet. Methods We examined the expression of DLEC1 by semi-quantitative reverse transcription (RT)-PCR, and evaluated the promoter methylation of DLEC1 by methylation-specific PCR (MSP) and bisulfite genomic sequencing (BGS) in common lymphoma cell lines and tumors. Results Here we report that DLEC1 is readily expressed in normal lymphoid tissues including lymph nodes and PBMCs, but reduced or silenced in 70% (16/23) of non-Hodgkin and Hodgkin lymphoma cell lines, including 2/6 diffuse large B-cell (DLBCL), 1/2 peripheral T cell lymphomas, 5/5 Burkitt, 6/7 Hodgkin and 2/3 nasal killer (NK)/T-cell lymphoma cell lines. Promoter CpG methylation was frequently detected in 80% (20/25) of lymphoma cell lines and correlated with DLEC1 downregulation/silencing. Pharmacologic demethylation reversed DLEC1 expression in lymphoma cell lines along with concomitant promoter demethylation. DLEC1 methylation was also frequently detected in 32 out of 58 (55%) different types of lymphoma tissues, but not in normal lymph nodes. Furthermore, DLEC1 was specifically methylated in the sera of 3/13 (23%) Hodgkin lymphoma patients. Conclusions Thus, methylation-mediated silencing of DLEC1 plays an important role in multiple lymphomagenesis, and may serve as a non-invasive tumor marker for lymphoma diagnosis.

Published
2012
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