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1,015 results on '"Srivastava, Sunil K."'

17. Quantitative Analysis of Ellipsoid Zone in Acute Posterior Multifocal Placoid Pigment Epitheliopathy

Author

Browne, Andrew W, Ansari, Waseem, Hu, Ming, Baynes, Kimberly, Lowder, Careen Y, Ehlers, Justis P, and Srivastava, Sunil K

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Neurosciences, Eye Disease and Disorders of Vision, Biomedical Imaging, Bioengineering, automated analysis, ellipsoid zone, manual grading, optical coherence tomography, uveitis
Abstract

PURPOSE:: Quantitative end points for uveitis are needed. Here we quantify the rate of ellipsoid zone (EZ) recovery on optical coherence tomography (OCT) and correlate it with visual acuity (VA) improvement in patients with acute posterior multifocal placoid pigmented epitheliopathy (APMPPE). We use automated and manually graded EZ area analysis to assess EZ recovery in APMPPE. METHODS:: We performed a retrospective review of 9 APMPPE cases (18 eyes) that had characteristic clinical examination and fluorescein angiography findings, outer retinal disruption on spectral-domain OCT, and treatment with systemic steroids after an unambiguous laboratory workup. The EZ was delineated using custom software to perform automated analysis and manual grading by 2 independent physicians. Quantitation of EZ changes was performed in ImageJ (National Institutes of Health). EZ maps were compared with equivalent findings from EZ en face OCT segmentation. RESULTS:: The 9 cases in our study were followed for an average of 198 days. Symptomatic improvement occurred in all eyes. VA recovery occurred in 83% of eyes and depended on presenting foveal involvement. Positive slopes of EZ area over time demonstrated recovery. EZ recovery profiles determined by manual and automated software demonstrated high Pearson correlation coefficients (0.78-0.94). Slab en face EZ analysis demonstrated moderate agreement. CONCLUSIONS:: EZ recovery correlates with symptomatic and VA recovery. Automated EZ analysis shows strong agreement with manually graded EZ analysis in APMPPE. EZ recovery in patients with APMPPE provides a biomarker for recovery and may be applied to other diseases affecting the outer retina.

Published
2020

19. Vibrational Spectra of Pb2Bi2Te3, PbBi2Te4 and PbBi4Te7 Topological Insulators: Temperature Dependent Raman and Theoretical Insight from DFT Simulations

Author

Mal, Priyanath, Bera, Ganesh, Turpu, G. R., Srivastava, Sunil. K., Gangan, A., Chakraborty, Brahmananda, Das, Bipul, and Das, Pradip

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Superconductivity
Abstract

We present temperature dependent frequency shift and line broadening of phonon modes by insertion of atomic layers of Pb and PbTe in the prototype 3D topological insulator Bi2Te3, using Raman spectroscopy. Good quality single crystals of Pb2Bi2Te3, PbBi2Te4 and PbBi4Te7 are grown using the modified Bridgman technique. The Raman modes show progressive blue shift with the decrease in temperature from 298 K to 93 K in Pb2Bi2Te3, PbBi2Te4 and PbBi4Te7 is due to anharmonic vibrations of the lattice as well as increasing strength of Bi-Te covalent interactions. Experimental results are complemented by extensive density functional theory calculations where a reasonable matching between experimental and computational data is found. Chemical pressure, induces by the insertion of Pb and PbTe layers in Bi2Te3, modifies the interactions at the boundaries of the quintuple-layers which is evident from the evolution of mode. The enhancement of out-of-plane Bi-Te vibrations with respect to in-plane Bi-Te vibrations are observed at low temperatures.

Published
2018
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21. Final Outcomes from the Randomized RECOVERY Trial of Aflibercept for Retinal Nonperfusion in Proliferative Diabetic Retinopathy

Author

Wykoff, Charles C., Nittala, Muneeswar G., Villanueva Boone, Cecilia, Yu, Hannah J., Zhou, Brenda, Fan, Wenying, Velaga, Swetha Bindu, Rusakevich, Alexander M., Lampen, Shaun I.R., Ip, Michael S., Sadda, SriniVas R., Ehlers, Justis P., Srivastava, Sunil K., Reese, Jamie L., Babiuch, Amy, Talcott, Katherine, Figueiredo, Natalia, Yordi, Sari, Hach, Jenna, Ou, William C., Fish, Richard H., Benz, Matthew S., Chen, Eric, Kim, Rosa Y., Major, James C., Jr., O’Malley, Ronan E., Brown, David M., Shah, Ankoor R., Schefler, Amy C., Wong, Tien P., Henry, Christopher R., Patel, Sagar B., Nguyen, Vy T., and Larkin, Kelly L.

Published
2022
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23. Treatment and Visual Outcomes in Pediatric Patients with Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy: A Cohort Study.

Author

Maccora, Ilaria, Ebert, Jared J., Schulert, Grant S., Quinlan-Waters, Megan, Duell, Alexandra, Huggins, Jennifer L., Sapp, Cameron C., Nguyen, Tiffany, Srivastava, Sunil K., Sood, Arjun B., and Angeles-Han, Sheila T.

Subjects
OPTICAL coherence tomography, CHILD patients, MACULAR edema, VISUAL acuity, AUTOINFLAMMATORY diseases
Abstract

Background: Autosomal dominant neovascular inflammatory vitreoretinopathy (NIV), formerly called "ADNIV," is a rare autoinflammatory condition mainly of adulthood caused by mutations in calcium-activated calpain-5 protease (CAPN5). Our aim is to report the treatment and visual outcomes of children newly diagnosed with NIV after systemic treatment. Methods: We reviewed charts of patients ≤18 years old with CAPN5 gene mutation, ocular findings consistent with NIV, and treated with systemic immunosuppression for a minimum of 6 months. Treatment response was based on ophthalmic examination, ultra-widefield fluorescein-angiography (UWFFA), and optical coherence tomography (OCT). Results: Eight children (16 eyes) were diagnosed with NIV at a median age of 14 (Range [R] 9–16) years, with a median follow-up of 18 months (R6–20). At diagnosis, one patient had impaired visual acuity (VA > 0.4), eight had vascular leakage, two had neovascularization, and three had macular edema. All responded to oral or local glucocorticoids but was not sustained. Systemic immunosuppression was started in seven patients with methotrexate and infliximab after a median time from diagnosis of 1.5 months (R0.5–2) and 3.2 months (R2.5–3.1), respectively. Infliximab was discontinued in all after a median time of 7 months (R3.5–10) for ineffectiveness, and 5/7 switched to tocilizumab and 1 to adalimumab. Five failed to respond (4 tocilizumab, 1 adalimumab) and one had a minimal response to tocilizumab Conclusions: We report on the systemic treatment response of seven children with ADNIV treated with methotrexate, infliximab, and tocilizumab. None were able to control disease. Further studies are needed to understand long-term outcomes and the utility of systemic immunosuppression. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Patient-Reported Complications after Intravitreal Injection and Their Predictive Factors

Author

Ramos, Michael S., Xu, Lucy T., Singuri, Srinidhi, Castillo Tafur, Julio C., Arepalli, Sruthi, Ehlers, Justis P., Kaiser, Peter K., Singh, Rishi P., Rachitskaya, Aleksandra V., Srivastava, Sunil K., Sears, Jonathan E., Schachat, Andrew P., Babiuch, Amy S., Sharma, Sumit, Martin, Daniel F., Lowder, Careen Y., Singh, Arun D., Yuan, Alex, and Nowacki, Amy S.

Published
2021
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34. Intraoperative Optical Coherence Tomography–Assisted Chorioretinal Biopsy in the DISCOVER Study

Author

Browne, Andrew W, Ehlers, Justis P, Sharma, Sumit, and Srivastava, Sunil K

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Aged, Aged, 80 and over, Choroid, Choroid Diseases, Female, Humans, Image-Guided Biopsy, Intraoperative Period, Male, Middle Aged, Prospective Studies, Retina, Retinal Diseases, Tomography, Optical Coherence, Opthalmology and Optometry, Ophthalmology & Optometry, Ophthalmology and optometry
Abstract

TOPIC: To assess the role and utility of intraoperative optical coherence tomography (iOCT) guidance during pars plana vitrectomy with chorioretinal biopsy for patients with suspicious chorioretinal lesions. CLINICAL RELEVANCE: Chorioretinal lesions suspicious for malignancy sometimes require surgical biopsy for diagnosis and treatment guidance. Biopsy site selection is currently guided by presurgical imaging, and clinical assessment. We sought to determine whether iOCT provides useful information for biopsy site selection to ensure a diagnostic specimen and assessment of wound repair after biopsy. MATERIALS AND METHODS: DISCOVER is a prospective study examining microscope-integrated iOCT systems in ophthalmic surgery. In this report, we examine all eyes in the DISCOVER study that underwent chorioretinal biopsy. Clinical characteristics, surgical technique, and imaging findings were reviewed. In addition, surgeon feedback data on iOCT utility and value to the procedure was also evaluated. RESULTS: Six eyes were identified within the DISCOVER study that underwent chorioretinal biopsy. iOCT was used to assess retinal and choroidal lesions prior to chorioretinal incision. Following biopsy, iOCT was utilized to assess retinal attachment and wound margin integrity. Additionally, iOCT was performed in real-time during biopsy to ensure proper biopsy depth and position. In 2 cases, preoperative OCT evaluation of retinal lesions was not possible. Utilizing iOCT, comprehensive evaluation of anatomic features was successfully performed prior to biopsy. This facilitated identification of biopsy sites most likely to provide a diagnostic sample based on lesion morphology on iOCT. After completion of chorioretinal biopsy, iOCT verified completeness of biopsy site and the retinal-RPE relationship (e.g., complete apposition, partial detachment). CONCLUSION: Microscope-integrated iOCT provides real-time guidance of biopsy site selection and verification of biopsy site stability following specimen collection.

Published
2017

35. Ultrawidefield Fluorescein Angiography and OCT Findings in Children and Young Adults with Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy

Author

Ebert, Jared J., Maccora, Ilaria, Sapp, Camera C., Nguyen, Tiffany, Sisk, Robert A., Srivastava, Sunil K., Angeles-Han, Sheila T., and Sood, Arjun B.

Abstract

Autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) is a rare genetic (CAPN5) autoimmune condition typically diagnosed in adulthood and characterized by a triad of inflammation, retinal degeneration, and neovascularization. We report novel multimodal imaging findings in children and young adults with ADNIV, and early treatment response to short-duration local and systemic corticosteroids.

Published
2024
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40. Long-Term Outcomes of Scleral-Sutured Fixated Secondary Intraocular Lenses in Patients With Uveitis.

Author

Mammo, Danny A., Steinkerchner, Megan, Sharma, Sumit, Baynes, Kimberly, and Srivastava, Sunil K.

Subjects
INTRAOCULAR lenses, SUTURES, SCLERA surgery, TISSUE fixation (Histology), VISUAL acuity
Abstract

Objective: This study examined the long-term outcomes of scleral-sutured fixated intraocular lenses (SSIOLs) in patients with uveitis. Patients and Methods: Retrospective, consecutive review of uveitis patients with SSIOL fixation from January 2017 to December 2020. SSIOL techniques included four-point fixation with the Akreos A060 or enVista MX60 (Bausch + Lomb) lens, or Hoffman's pockets rescue. Results: Thirteen eyes of 13 patients received an SSIOL (9 AO60, 2 MX60, 2 Hoffman's pockets). Diagnoses included pan- (9), anterior (2), and posterior uveitis (2). Average LogMAR best-corrected visual acuity pre- and postoperatively was 1.01 (Snellen ∼20/200) and 0.50 (Snellen ∼20/60), respectively (P = 0.003). No patients had postoperative SSIOL dislocation or conjunctival suture erosion. Six patients (46%) had uveitis flares postoperatively. Average follow-up was 50.2 months (range = 36.8 to 67.5). Conclusion: This series demonstrates a 0% dislocation and suture exposure rate. Risks of uveitis flares postoperatively are high despite aggressive perioperative control but are manageable with current treatments; therefore, patients must be continually monitored. [Ophthalmic Surg Lasers Imaging Retina 2024;55:443–447.] [ABSTRACT FROM AUTHOR]

Published
2024
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50. Intravitreal Aflibercept for Retinal Nonperfusion in Proliferative Diabetic Retinopathy: Outcomes from the Randomized RECOVERY Trial

Author

Wykoff, Charles C., Nittala, Muneeswar G., Zhou, Brenda, Fan, Wenying, Velaga, Swetha Bindu, Rusakevich, Alexander M., Lampen, Shaun I.R., Ip, Michael S., Sadda, SriniVas R., Ehlers, Justis P., Srivastava, Sunil K., Reese, Jamie L., Babiuch, Amy, Talcott, Katherine, Figueiredo, Natalia, Hach, Jenna, Ou, William C., Fish, Richard H., Benz, Matthew S., Chen, Eric, Kim, Rosa Y., Major, James C., Jr., O’Malley, Ronan E., Brown, David M., Shah, Ankoor R., Schefler, Amy C., Wong, Tien P., and Henry, Christopher R.

Published
2019
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