Author: "Stéphane Mazières" - Searchworks@Jio Institute Digital Library Search Results

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104 results on '"Stéphane Mazières"'

1. Synthesis, Characterizations, and Quantum Chemical Investigations on Imidazo[1,2‑a]pyrimidine-Schiff Base Derivative: (E)‑2-Phenyl‑N‑(thiophen-2-ylmethylene)imidazo[1,2‑a]pyrimidin-3-amine

Author: Mohamed Azzouzi, Omar Azougagh, Abderrahim Ait Ouchaoui, Salah eddine El hadad, Stéphane Mazières, Soufian El Barkany, Mohamed Abboud, and Adyl Oussaid
Subjects: Chemistry, QD1-999
Published: 2023
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2. Blood groups of Neandertals and Denisova decrypted.

Author: Silvana Condemi, Stéphane Mazières, Pierre Faux, Caroline Costedoat, Andres Ruiz-Linares, Pascal Bailly, and Jacques Chiaroni
Subjects: Medicine, Science
Abstract: Blood group systems were the first phenotypic markers used in anthropology to decipher the origin of populations, their migratory movements, and their admixture. The recent emergence of new technologies based on the decoding of nucleic acids from an individual's entire genome has relegated them to their primary application, blood transfusion. Thus, despite the finer mapping of the modern human genome in relation to Neanderthal and Denisova populations, little is known about red cell blood groups in these archaic populations. Here we analyze the available high-quality sequences of three Neanderthals and one Denisovan individuals for 7 blood group systems that are used today in transfusion (ABO including H/Se, Rh (Rhesus), Kell, Duffy, Kidd, MNS, Diego). We show that Neanderthal and Denisova were polymorphic for ABO and shared blood group alleles recurrent in modern Sub-Saharan populations. Furthermore, we found ABO-related alleles currently preventing from viral gut infection and Neanderthal RHD and RHCE alleles nowadays associated with a high risk of hemolytic disease of the fetus and newborn. Such a common blood group pattern across time and space is coherent with a Neanderthal population of low genetic diversity exposed to low reproductive success and with their inevitable demise. Lastly, we connect a Neanderthal RHD allele to two present-day Aboriginal Australian and Papuan, suggesting that a segment of archaic genome was introgressed in this gene in non-Eurasian populations. While contributing to both the origin and late evolutionary history of Neanderthal and Denisova, our results further illustrate that blood group systems are a relevant piece of the puzzle helping to decipher it.
Published: 2021
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3. Prehistoric migrations through the Mediterranean basin shaped Corsican Y-chromosome diversity.

Author: Julie Di Cristofaro, Stéphane Mazières, Audrey Tous, Cornelia Di Gaetano, Alice A Lin, Paul Nebbia, Alberto Piazza, Roy J King, Peter Underhill, and Jacques Chiaroni
Subjects: Medicine, Science
Abstract: The rarity of human remains makes it difficult to apprehend the first settlements in Corsica. It is admitted that initial colonization could have occurred during the Mesolithic period when glaciations would have shortened the open water travel distance from the continent. Mesolithic sites in Corsica show relatively short and irregular occupation, and suggest discontinuous settling of very mobile groups probably traveling by boat. Previous genetic studies on Corsican populations showed internal differentiation and a relatively poor genetic relationship with continental populations, despite intense historical contacts, however local Mesolithic-based genetic inheritance has never been properly estimated. The aim of this study was to explore the Corsican genetic profile of Y-chromosomes in order to trace the genetic signatures back to the first migrations to Corsica. This study included 321 samples from men throughout Corsica; samples from Provence and Tuscany were added to the cohort. All samples were typed for 92 Y-SNPs, and Y-STRs were also analyzed. Results revealed highly differentiated haplogroup patterns among Corsican populations. Haplogroup G had the highest frequency in Corsica, mostly displaying a unique Y-STR profile. When compared with Provence and Tuscany, Corsican populations displayed limited genetic proximity. Corsican populations present a remarkable Y-chromosome genetic mixture. Although the Corsican Y-chromosome profile shows similarities with both Provence and to a lesser extent Tuscany, it mainly displays its own specificity. This study confirms the high level of genetic diversity in Corsican populations and backs genetic contributions from prehistoric migrations associated with the Mesolithic, Neolithic and Metal Age eras, rather than from historical movements to Corsica, respectively attested by frequencies and TMRCA of haplogroups G2a-L91 and G2a-P15, J2a-M241 and J2-DYS445 = 6, R1b-U152 and R1b-U106. These results suggest that marine routes to reach the Corsican coast in many different points may have led to such a genetic heterogeneity.
Published: 2018
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4. Estructura genética e historia biológica de tres poblaciones amerindias de Guyana Francesa / Genetics struture and biological history of three amerindian populations for French Guyana

Author: Stéphane Mazières, Evelyne Guitard, André Sevin, Nicole Joly, Jean-Michel Dugoujon, Francisco M Salzano, Georges Larrouy, and Eric Crubézy
Subjects: Anthropology, GN1-890, Physical anthropology. Somatology, GN49-298
Abstract: Se conoce poco sobre la historia de las poblaciones indígenas de Guyana francesa, principalmente porque la selva dificulta las investigaciones arqueológicas así como la conservación del material orgánico. Una alternativa para el estudio de estas poblaciones es el análisis de su variabilidad genética, que se ha llevado a cabo a partir del DNA extraído de sueros previamente recolectados, y teniendo en cuenta otros grupos amerindios de la misma región geográfica. De las muestras de tres poblaciones de Guyana Francesa se seleccionaron 102 indivíduos según los datos genealógicos, y se analizaron los polimorfismos característicos de los haplogrupos mitocondriales amerindios. Únicamente los Kaliña poseen los cuatros linajes fundadores amerindios. Los Palikur carecen de los haplogrupos A y C y los Emerillon de las líneas C y D. La ausencia de dos linajes en los Palikur podría ser debida a su aislamiento genético provocado por una estructura social extremadamente endogámica, mientras que en el caso de los Emerillon, debe considerarse el dramático cuello de botella. Estos resultados sugieren que el poblamiento inicial de la región de las Guayanas presenta algunas particularidades debidas, en parte, a su ubicación geográfica un tanto distante, así como también sus estructuras sociales singulares.
Published: 2015

5. Revisiting the Diego Blood Group System in Amerindians: Evidence for Gene-Culture Comigration.

Author: Christophe Bégat, Pascal Bailly, Jacques Chiaroni, and Stéphane Mazières
Subjects: Medicine, Science
Abstract: Six decades ago the DI*A allele of the Diego blood group system was instrumental in proving Native American populations originated from Siberia. Since then, it has received scant attention. The present study was undertaken to reappraise distribution of the DI*A allele in 144 Native American populations based on current knowledge. Using analysis of variance tests, frequency distribution was studied according to geographical, environmental, and cultural parameters. Frequencies were highest in Amazonian populations. In contrast, DI*A was undetectable in subarctic, Fuegian, Panamanian, Chaco and Yanomama populations. Closer study revealed a correlation that this unequal distribution was correlated with language, suggesting that linguistic divergence was a driving force in the expansion of DI*A among Native Americans. The absence of DI*A in circumpolar Eskimo-Aleut and Na-Dene speakers was consistent with a late migratory event confined to North America. Distribution of DI*A in subtropical areas indicated that gene and culture exchanges were more intense within than between ecozones. Bolstering the utility of classical genetic markers in biological anthropology, the present study of the expansion of Diego blood group genetic polymorphism in Native Americans shows strong evidence of gene-culture comigration.
Published: 2015
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6. Afghan Hindu Kush: where Eurasian sub-continent gene flows converge.

Author: Julie Di Cristofaro, Erwan Pennarun, Stéphane Mazières, Natalie M Myres, Alice A Lin, Shah Aga Temori, Mait Metspalu, Ene Metspalu, Michael Witzel, Roy J King, Peter A Underhill, Richard Villems, and Jacques Chiaroni
Subjects: Medicine, Science
Abstract: Despite being located at the crossroads of Asia, genetics of the Afghanistan populations have been largely overlooked. It is currently inhabited by five major ethnic populations: Pashtun, Tajik, Hazara, Uzbek and Turkmen. Here we present autosomal from a subset of our samples, mitochondrial and Y- chromosome data from over 500 Afghan samples among these 5 ethnic groups. This Afghan data was supplemented with the same Y-chromosome analyses of samples from Iran, Kyrgyzstan, Mongolia and updated Pakistani samples (HGDP-CEPH). The data presented here was integrated into existing knowledge of pan-Eurasian genetic diversity. The pattern of genetic variation, revealed by structure-like and Principal Component analyses and Analysis of Molecular Variance indicates that the people of Afghanistan are made up of a mosaic of components representing various geographic regions of Eurasian ancestry. The absence of a major Central Asian-specific component indicates that the Hindu Kush, like the gene pool of Central Asian populations in general, is a confluence of gene flows rather than a source of distinctly autochthonous populations that have arisen in situ: a conclusion that is reinforced by the phylogeography of both haploid loci.
Published: 2013
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7. Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9.

Author: Vanessa R Paixão-Côrtes, Diogo Meyer, Tiago V Pereira, Stéphane Mazières, Jacques Elion, Rajagopal Krishnamoorthy, Marco A Zago, Wilson A Silva, Francisco M Salzano, and Maria Cátira Bortolini
Subjects: Medicine, Science
Abstract: A total of 172 persons from nine South Amerindian, three African and one Eskimo populations were studied in relation to the Paired box gene 9 (PAX9) exon 3 (138 base pairs) as well as its 5'and 3'flanking intronic segments (232 bp and 220 bp, respectively) and integrated with the information available for the same genetic region from individuals of different geographical origins. Nine mutations were scored in exon 3 and six in its flanking regions; four of them are new South American tribe-specific singletons. Exon3 nucleotide diversity is several orders of magnitude higher than its intronic regions. Additionally, a set of variants in the PAX9 and 101 other genes related with dentition can define at least some dental morphological differences between Sub-Saharan Africans and non-Africans, probably associated with adaptations after the modern human exodus from Africa. Exon 3 of PAX9 could be a good molecular example of how evolvability works.
Published: 2011
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8. Spectroscopic and electrochemical study of biomimetic catecholase and phenoxazinone synthase activities of in situ complexes bearing pyrazolic ligands

Author: Mohamed El Boutaybi, Abdeslam Mouadili, Adyl Oussaid, Stéphane Mazières, Rachid Touzani, Zahra Bahari, Faculté Polydisciplinaire de Taza, Université Sidi Mohamed Ben Abdellah - Fès [Université de Taza] (USMBA), Interactions moléculaires et réactivité chimique et photochimique (IMRCP), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Fédération de Recherche Fluides, Energie, Réacteurs, Matériaux et Transferts (FERMAT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), P3R - Polymères de Précision par Procédés Radicalaires (P3R), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT), Faculté Pluridisciplinaire de Nador, Laboratoire de Chimie Appliquée et Environnement | Laboratory of Applied and Environmental Chemistry [Université Mohammed Premier Oujda] (LCAE), and Université Mohammed Premier [Oujda]
Subjects: [CHIM]Chemical Sciences, General Chemistry
Abstract: International audience
Published: 2023

9. Lactide-derived monomers for radical thiocarbonyl addition ring-opening copolymerisation

Author: Oleksandr Ivanchenko, Stéphane Mazières, Simon Harrisson, Mathias Destarac, Interactions moléculaires et réactivité chimique et photochimique (IMRCP), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Fédération de Recherche Fluides, Energie, Réacteurs, Matériaux et Transferts (FERMAT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), P3R - Polymères de Précision par Procédés Radicalaires (P3R), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT), Institut Galien Paris-Sud (IGPS), and Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Polymers and Plastics, Organic Chemistry, [CHIM]Chemical Sciences, Bioengineering, Biochemistry
Abstract: The six-membered dl-thionolactide and dl-dithionolactide are reactive in radical ring-opening copolymerisation with a series of vinyl monomers to yield chemically degradable polymers.
Published: 2022

10. Ring size-reactivity relationship in radical ring-opening copolymerisation of thionolactones with vinyl pivalate

Author: Oleksandr Ivanchenko, Stéphane Mazières, Rinaldo Poli, Simon Harrisson, Mathias Destarac, Interactions moléculaires et réactivité chimique et photochimique (IMRCP), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Fédération de Recherche Fluides, Energie, Réacteurs, Matériaux et Transferts (FERMAT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), P3R - Polymères de Précision par Procédés Radicalaires (P3R), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT), Laboratoire de chimie de coordination (LCC), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), and French Ministry of Higher Education, Research and Innovation
Subjects: Polymers and Plastics, Organic Chemistry, [CHIM]Chemical Sciences, Bioengineering, Biochemistry
Abstract: International audience; The radical ring-opening copolymerisation of unsubstituted thionolactones of different ring sizes has been investigated. DFT calculations and experimental results show the importance of the stabilization of the intermediate ring-retained radical.
Published: 2022

11. Design, synthesis, and computational studies of novel imidazo[1,2-a]pyrimidine derivatives as potential dual inhibitors of hACE2 and spike protein for blocking SARS-CoV-2 cell entry

Author: Mohamed Azzouzi, Zainab El Ouafi, Omar Azougagh, Walid Daoudi, Hassan Ghazal, Soufian El Barkany, Rfaki Abderrazak, Stéphane Mazières, Abdelmalik El Aatiaoui, and Adyl Oussaid
Subjects: Inorganic Chemistry, Organic Chemistry, Spectroscopy, Analytical Chemistry
Published: 2023

12. Frequency and characterization of RHD and RHCE variants in the Noir Marron population from French Guiana

Author: Laurine Laget, Caroline Izard, Elisabeth Durieux‐Roussel, Lugdivine Filosa, Pascal Bailly, Stéphane Mazières, Jacques Chiaroni, Etablissement Français du Sang Provence-Alpes Côte-d'Azur et Corse (EFS), Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), and Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS)
Subjects: Suriname, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, Immunology, Culture, Immunology and Allergy, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Hematology
Abstract: The RH system is one of the most polymorphic blood group systems due to the proximity and opposite orientation of RHD and RHCE genes. Numerous alleles are described and can affect Rh protein expression. This complexity is especially evident in populations of African origin. We performed RHD and RHCE genotyping of the Noir Marron population in French Guiana. This population belongs to the Maroon community who are direct descendants of African slaves, who escaped from Dutch plantations, in the current day Suriname, during the 17th century. They represent an original ethnic group with highly blended culture.A total of 89 DNA samples were collected from four different ethnic groups of the Noir Marron population of French Guiana. RHD and RHCE genotyping was performed using DNA microarray and/or sequencing.Significant allelic diversity was shown, with 45% of individuals presenting an RHD gene variant (most common: RHD*DAU, RHD*DIVa, and RHD*DIIIa allele) and 9.4% with a partial D phenotype. Likewise, 85% presenting an RHCE gene variant and 9% a partial RH2 antigen. One original allele was identified in two D+ Noir Marron individuals: a hybrid RHD*DIIIa-CE(9)-D allele, encoding probably a partial D antigen and associated with an RHCE*ce(48C,733G,1006T) allele. The African diversity of RHD and RHCE genes is found in this population with preserved genetic but mixed cultural backgrounds. These data allow us to describe the characteristics of the RH system antigen and highlights a significant number of partial antigens with a risk of alloimmunization.
Published: 2022

13. Impact of societal and legal context on the blood supply of African‐ancestry populations in Western countries: A review of practices and the French example

Author: Pauline Oviedo, Yannick Jaffré, Bruno Danic, Stéphane Mazières, Jacques Chiaroni, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), and Etablissement Français du Sang Provence-Alpes Côte-d'Azur et Corse (EFS)
Subjects: [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, Black People, Blood Donors, Hematology, General Medicine, donor motivation, donor recruitment, ethics, United Kingdom, United States, Blood Group Antigens, Humans, anthropology, social norms, donors, Netherlands
Abstract: International audience; In Western countries, blood supply agencies encounter impediments in providing blood groups defined as rare or of interest, notably for sub-Saharan African ancestry (SSAA) recipients. To establish warning levels and anticipate future blood needs, an estimate of the current carriers of rare blood groups, both potential patients or donors, is crucial but complex. Indeed, if the strict needs can be estimated in medical terms, the modalities of blood product collection must be considered from an interdisciplinary perspective, at the interface of biological data and social norms. Here, we aim to understand how legal choices and a set of representations of otherness may influence the supply of rare blood for SSAA populations. After examining these issues, considering different norms and limits that govern French society, we compare this data with those of four Western countries facing the same difficulties (United States, United Kingdom, Italy and the Netherlands). This work began as part as the reflections of Social Lab, an institutional programme created by the French Blood Establishment (EFS). How can we effectively improve the qualitative blood coverage for SSAA populations? There is no unique solution, but there are many more or less effective answers. Comparison across countries reveals a strong influence of the socio-political histories and ethical choices before technical and medical considerations. We consider that an institutional policy is required to resolve recruitment issues of SSAA donors sustainably. Lastly, we introduce a working group called the EFS Social Lab, which aims to set up a monitoring mechanism for donors and societal trends to make blood donation effective.
Published: 2022

14. Five-Years Review of

Author: Pascal, Pedini, Lugdivine, Filosa, Nelly, Bichel, Christophe, Picard, Monique, Silvy, Jacques, Chiaroni, Caroline, Izard, Laurine, Laget, and Stéphane, Mazières
Subjects: Rh-Hr Blood-Group System, Gene Frequency, Haplotypes, Humans, Exons, Alleles
Abstract: Immunohematology laboratories are regularly facing transfusion issues due to serological weaknesses. Altered (partial) RH antigens account for most of them. In some situations
Published: 2022

15. Introduction Os, sang, gènes, cultures

Author: Caroline Costedoat and Stéphane Mazières
Subjects: Genetics, General Medicine, Biology, Gene
Published: 2020

16. Diego, Asie et Amérique : comment la répartition d’un seul groupe sanguin suffit à décrire le peuplement de deux continents

Author: Caroline Costedoat and Stéphane Mazières
Subjects: General Medicine
Published: 2020

17. Azo-Derived Symmetrical Trithiocarbonate for Unprecedented RAFT Control

Author: Oleksandr Ivanchenko, Sonia Mallet-Ladeira, Stéphane Mazières, Maksym Odnoroh, Mathias Destarac, Marc Guerre, Interactions moléculaires et réactivité chimique et photochimique (IMRCP), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Fédération de Recherche Fluides, Energie, Réacteurs, Matériaux et Transferts (FERMAT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), P3R - Polymères de Précision par Procédés Radicalaires (P3R), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT), Laboratoire de chimie de coordination (LCC), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), and ANR-16-CE29-0014,RAFTSWITCH,Agents de Transfert RAFT Modulables pour la Polymérisation Radicalaire Contrôlée.(2016)
Subjects: Trithiocarbonate, Chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Radical polymerization, Leaving group, Chain transfer, General Chemistry, Raft, Methacrylate, Biochemistry, Block copolymers, Catalysis, Polymerization, Colloid and Surface Chemistry, [CHIM.POLY]Chemical Sciences/Polymers, Polymer chemistry, Copolymer, Thiol, Thermoplastic elastomer
Abstract: International audience; Bis(2-cyanopropan-2-yl)trithiocarbonate (TTC-bCP) is a new symmetrical trithiocarbonate with the best leaving group ever reported for reversible addition–fragmentation chain transfer (RAFT) polymerization. We propose an elegant route to obtain TTC-bCP starting from 2,2′-azobis(2-methylpropionitrile) (AIBN) as a donor of the 2-cyanopropan-2-yl group. TTC-bCP allowed the preparation of a high-molar-mass (Mn ≈ 135 kg mol–1) methyl methacrylate–n-butyl acrylate–methyl methacrylate triblock copolymer with unprecedented control (D̵ = 1.04) in reversible-deactivation radical polymerization. Rheology measurements of this triblock copolymer showed a typical thermoplastic elastomer behavior with a steady rubbery plateau up to 120 °C.
Published: 2021

18. Blood groups of Neandertals and Denisova decrypted

Author: Andres Ruiz-Linares, Pierre Faux, Pascal Bailly, Caroline Costedoat, Jacques Chiaroni, Silvana Condemi, Stéphane Mazières, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Dept of Genetics, Evolution and Environment [London] (UCL-GEE), University College of London [London] (UCL), School of Life Sciences [Fudan University], Fudan University [Shanghai], Etablissement Français du Sang Provence-Alpes Côte-d'Azur et Corse (EFS), and Mazières, Stéphane
Subjects: 0301 basic medicine, Neanderthal, Hominids, Heredity, Physiology, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, Social Sciences, Homozygosity, 0302 clinical medicine, INDEL Mutation, Medicine and Health Sciences, Neanderthals, education.field_of_study, Multidisciplinary, biology, Fossils, Paleogenetics, Hominidae, Body Fluids, [SHS.ANTHRO-BIO] Humanities and Social Sciences/Biological anthropology, Genetic Mapping, Blood, Phenotype, Blood Group Antigens, Medicine, Physical Anthropology, Anatomy, Research Article, Genotype, Science, Population, Variant Genotypes, 03 medical and health sciences, Archaic Humans, ABO blood group system, biology.animal, Paleoanthropology, Genetic variation, Genetics, Hominins, Animals, Allele, education, Denisovan, Alleles, Evolutionary Biology, Polymorphism, Genetic, Population Biology, Haplotype, Biology and Life Sciences, Paleontology, Genetic Variation, biology.organism_classification, 030104 developmental biology, Haplotypes, Evolutionary biology, Genetic Loci, Anthropology, Earth Sciences, Blood Groups, 030217 neurology & neurosurgery, Population Genetics
Abstract: International audience; Red cell blood group systems are crucial for safe transfusion, transplantation, and pregnancy monitoring. In addition, blood groups have long been investigated to decipher the origin of human populations, migration, adaptation, and admixture. However, since the extensive use of DNA polymorphisms in Anthropology, blood groups have been relegated to their primary application, blood transfusion. The finer genomic mapping of some Neanderthal and Denisova individuals about modern humans has provided significant evidence on the evolutionary history of both archaic and modern humans. However, despite their medical and anthropological interest, little is known about blood groups in archaic populations. To better understand the origin, expansion and encounter with Homo sapiens, we reappraised the available high-quality sequences of three Neanderthals (Vindija 33.19, Chagyrskaya 8, Altai Neandertal) and one Denisovan (Denisova 3) for 11 genes of the 7 blood group systems that are routinely screened in transfusion: ABO including H/ Se, Rh (Rhesus), Kell, Duffy, Kidd, MNS, and Diego. We show that Neanderthals and Denisova were polymorphic for ABO and shared blood group alleles recurrent in modern Sub-Saharan populations. Furthermore, we found ABO-related alleles currently preventing viral gut infection and all Neanderthal shared RHD and RHCE alleles nowadays associated with a high risk of hemolytic disease of the fetus and newborn. Such a common blood group pattern across time and space is coherent with a Neanderthal population of low genetic diversity exposed to possible pregnancies with complications. Lastly, we connect the Neanderthal RHD allele to two present-day Aboriginal Australians and Papuan, suggesting that a segment of the archaic genome was introgressed in this gene in non-Eurasian populations before their expansion towards Oceania. While contributing to both the origin and late evolutionary history of Neanderthal and Denisova, our results further illustrate that blood group systems remain effective anthropological markers.
Published: 2021

19. Genome-wide analysis of Corsican population reveals a close affinity with Northern and Central Italy

Author: Luísa Pereira, Alena Kushniarevich, Julie Di Cristofaro, Erwan Pennarun, Mait Metspalu, Stéphane Mazières, Erika Tamm, Jacques Chiaroni, Francesco Montinaro, Alessandro Raveane, Ornella Semino, Etablissement Français du Sang - Alpes-Méditerranée (EFS - Alpes-Méditerranée), Etablissement Français du Sang, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), University of Tartu, Università degli Studi di Pavia, Archaeogenetics Laboratory, Università degli Studi di Pavia = University of Pavia (UNIPV), and Instituto de Investigação e Inovação em Saúde
Subjects: Population Dynamics, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, Population, Genome wide analysis, lcsh:Medicine, Mediterranean Basin, Genome, White People, Article, 03 medical and health sciences, 0302 clinical medicine, Africa, Northern, Gene Frequency, Italy / ethnology, Genetic variation, Humans, Selection, Genetic, education, lcsh:Science, European Continental Ancestry Group / genetics, Whole Genome Sequencing / methods, Allele frequency, Phylogeny, 030304 developmental biology, 0303 health sciences, education.field_of_study, Multidisciplinary, Whole Genome Sequencing, 030305 genetics & heredity, Haplotype, lcsh:R, High-Throughput Nucleotide Sequencing, Publisher Correction, language.human_language, Genetics, Population, Geography, Italy, Haplotypes, Evolutionary biology, language, France / ethnology, lcsh:Q, France, European Continental Ancestry Group / ethnology, Genetic isolate, Corsican, 030217 neurology & neurosurgery
Abstract: Despite being the fourth largest island in the Mediterranean basin, the genetic variation of Corsica has not been explored as exhaustively as Sardinia, which is situated only 11 km South. However, it is likely that the populations of the two islands shared, at least in part, similar demographic histories. Moreover, the relative small size of the Corsica may have caused genetic isolation, which, in turn, might be relevant under medical and translational perspectives. Here we analysed genome wide data of 16 Corsicans, and integrated with newly (33 individuals) and previously generated samples from West Eurasia and North Africa. Allele frequency, haplotype-based, and ancient genome analyses suggest that although Sardinia and Corsica may have witnessed similar isolation and migration events, the latter is genetically closer to populations from continental Europe, such as Northern and Central Italians. We thank all volunteers who donated their DNA samples. We would like to thank Bayazit Yunusbayev for helpful discussions, Viljo Soo for his help in genotyping and Tuuli Reisberg for assistance in data management. Computational analyses were performed at the High Performance Computing Center of the University of Tartu. This research was supported by institutional research funding IUT (IUT24-1) of the Estonian Ministry of Education and Research (ET, EP); the Estonian Research Council grants PUT (PRG243) (EP, MM) and PUT (PUT1339) (AK); the European Union through the European Regional Development Funds with projects No. 2014-2020.4.01.16-0030 (MM, FM) and No. 2014-2020.4.01.15-0012 (MM); the European Union through Horizon 2020 grant no. 810645 (MM); the University of Pavia strategic theme “Towards a governance model for international migration: an interdisciplinary and diachronic perspective” (MIGRAT-IN-G) (OS); the Italian Ministry of Education, University and Research (MIUR): Dipartimenti di Eccellenza Program (2018–2022), Dept. of Biology and Biotechnology “L. Spallanzani”, University of Pavia (AR and OS).
Published: 2019

20. ε-Thionocaprolactone: an accessible monomer for preparation of degradable poly(vinyl esters) by radical ring-opening polymerization

Author: Mathias Destarac, Stéphane Mazières, Oleksandr Ivanchenko, Simon Harrisson, Guilhem Coste, Ugo Authesserre, Interactions moléculaires et réactivité chimique et photochimique (IMRCP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Laboratoire de Chimie des Polymères Organiques (LCPO), Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Fédération de Recherche Fluides, Energie, Réacteurs, Matériaux et Transferts (FERMAT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), P3R - Polymères de Précision par Procédés Radicalaires (P3R), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and Université de Bordeaux (UB)-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Polymers and Plastics, Dispersity, Vinyl ester, Bioengineering, 02 engineering and technology, macromolecular substances, 010402 general chemistry, 01 natural sciences, Biochemistry, Ring-opening polymerization, chemistry.chemical_compound, Polymer chemistry, Copolymer, [CHIM]Chemical Sciences, Reversible addition−fragmentation chain-transfer polymerization, Chemistry, organic chemicals, Organic Chemistry, technology, industry, and agriculture, food and beverages, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Monomer, Yield (chemistry), 0210 nano-technology, Caprolactone
Abstract: The 7-membered cyclic thionolactone, e-thionocaprolactone (TCL), undergoes radical copolymerization with vinyl esters to form degradable copolymers. While most radical ring-opening monomers require laborious and low-yielding syntheses, TCL can be prepared in one step from caprolactone (75% yield). TCL copolymerizes readily with vinyl esters, but is unreactive towards more activated monomers and does not homopolymerize under radical conditions. The molecular weight and to some extent the dispersity of the TCL/vinyl ester copolymers can be controlled via xanthate-mediated RAFT polymerization in the range of 5–20 kg mol−1. Analysis of the copolymer structure shows a high level of TCL–TCL dyads, suggesting that the terminal copolymerization model does not accurately describe TCL copolymerization.
Published: 2021

21. L’histoire évolutive de Néanderthal et Denisova vue par les systèmes des groupes sanguins

Author: Silvana Condemi, Stéphane Mazières, Caroline Costedoat, Pascal Bailly, Chiaroni Jacques, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), and Etablissement Français du Sang Provence-Alpes Côte-d'Azur et Corse (EFS)
Subjects: [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2021

22. Well-Defined P III -Terminated Polymers from Phosphorylated Carbodithioate RAFT Agents

Author: Andrii Karpus, Eric Manoury, Rinaldo Poli, Simon Harrisson, Mathias Destarac, Stéphane Mazières, Laboratoire de chimie de coordination (LCC), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Interactions moléculaires et réactivité chimique et photochimique (IMRCP), Université de Toulouse (UT)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Fédération de Recherche Fluides, Energie, Réacteurs, Matériaux et Transferts (FERMAT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie des Polymères Organiques (LCPO), Université de Bordeaux (UB)-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Team 1 LCPO : Polymerization Catalyses & Engineering, Université de Bordeaux (UB)-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), P3R - Polymères de Précision par Procédés Radicalaires (P3R), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT), Centre National de la Recherche Scientifique (CNRS), ANR-16-CE29-0014,RAFTSWITCH,Agents de Transfert RAFT Modulables pour la Polymérisation Radicalaire Contrôlée.(2016), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC), and Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)
Subjects: Polymers and Plastics, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Inorganic Chemistry, chemistry.chemical_compound, Polymer chemistry, Materials Chemistry, Vinyl acetate, Reversible addition−fragmentation chain-transfer polymerization, [CHIM.COOR]Chemical Sciences/Coordination chemistry, Nuclear magnetic resonance spectroscopy, chemistry.chemical_classification, Acrylate, RAFT polymerization, Chemistry, Organic Chemistry, Leaving group, Chain transfer, Polymer, 021001 nanoscience & nanotechnology, Phosphorylated carbodithioates, 3. Good health, 0104 chemical sciences, Monomer, [CHIM.POLY]Chemical Sciences/Polymers, Polymerization, 0210 nano-technology
Abstract: International audience; Five S-alkyl di-tert-butylphosphorylated carbodithioates, Z–C(S)SR, were studied as chain transfer agents (CTAs) in the RAFT polymerization of vinyl monomers. These phosphorus-containing CTAs involve new PIII and PV moieties in the Z group (phosphine-borane or free phosphine). Two of them, with an S-bonded 1-methoxycarbonylethyl group as leaving group, have not previously been described. The CTAs with a PV Z group provide good control over the polymerization of styrene (St) and n-butyl acrylate (nBA). Molar masses are close to theoretical values, and dispersities are consistently low during polymerization. The monitoring of polymerization by 31P NMR spectroscopy supports the controlled character and the integrity of the polymer chain ends. Conversely, they inhibit the polymerization of the less-activated monomer vinyl acetate (VAc). The reactivity of the CTAs with a PIII Z group mainly depends on the reaction medium, and their performance for St, nBA, and VAc was surprising and unexpected. Theoretical calculations were carried out to rationalize their behavior. Finally, an innovative strategy was developed to obtain well-controlled polymers with free phosphine ω-chain ends.
Published: 2021

23. Quench ionic flash nano precipitation as a simple and tunable approach to decouple growth and functionalization for the one-step synthesis of functional LnPO4-based nanoparticles in water

Author: Jean-Daniel Marty, Ihor Kulai, Leah Behar, Nathalie M. Pinkerton, Stéphane Mazières, Christophe Mingotaud, Baptiste Amouroux, Mathias Destarac, Stefan Chassaing, Khadidja Hadri, Interactions moléculaires et réactivité chimique et photochimique (IMRCP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (SPCMIB), Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Fédération de Recherche Fluides, Energie, Réacteurs, Matériaux et Transferts (FERMAT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), IDeAS - Interfaces Dynamiques et Assemblages Stimulables (IDeAS), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT), P3R - Polymères de Précision par Procédés Radicalaires (P3R), and Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Materials science, Metals and Alloys, Ionic bonding, Nanoparticle, Nanotechnology, One-Step, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 6. Clean water, Catalysis, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Nanomaterials, Nano, Materials Chemistry, Ceramics and Composites, [CHIM]Chemical Sciences, Surface modification, 0210 nano-technology, ComputingMilieux_MISCELLANEOUS, Decoupling (electronics)
Abstract: A novel, one-step method for the synthesis of functional, organic–inorganic hybrid nanoparticles is reported. The quench ionic Flash NanoPrecipitation (qiFNP) method enables the straightforward synthesis of nanoparticles by decoupling the formation of the inorganic core and surface functionalization. As a proof-of-concept, the qiFNP method was successfully applied for the tunable and highly controlled synthesis of various LnPO4-based nanomaterials for bioimaging applications.
Published: 2018

24. Disposer des produits sanguins indispensables aux populations d’origines africaines

Author: Yannick Jaffré, Jacques Chiaroni, Pauline Oviedo, Bruno Danic, and Stéphane Mazières
Subjects: Biochemistry (medical), Clinical Biochemistry, Hematology
Published: 2021

25. Alkyl Triarylstannanecarbodithioates: Synthesis, Crystal Structures, and Efficiency in RAFT Polymerization

Author: Stéphane Mazières, Nathalie Saffon-Merceron, Ihor Kulai, Zoia Voitenko, Mathias Destarac, Interactions moléculaires et réactivité chimique et photochimique (IMRCP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC), National Taras Shevchenko University of Kiev, Anthropologie Moléculaire et Imagerie de Synthèse (AMIS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Laboratoire Hétérochimie Fondamentale et Appliquée (LHFA), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Fédération de Recherche Fluides, Energie, Réacteurs, Matériaux et Transferts (FERMAT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), P3R - Polymères de Précision par Procédés Radicalaires (P3R), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT), Université de Toulouse (UT), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées
Subjects: chemistry.chemical_classification, 010405 organic chemistry, Organic Chemistry, Chain transfer, General Chemistry, Raft, Nuclear magnetic resonance spectroscopy, Polymer, 010402 general chemistry, 01 natural sciences, Catalysis, 0104 chemical sciences, End-group, chemistry, Polymerization, Polymer chemistry, [CHIM]Chemical Sciences, Reversible addition−fragmentation chain-transfer polymerization, ComputingMilieux_MISCELLANEOUS, Alkyl
Abstract: Eight alkyl triarylstannanecarbodithioates were synthesized starting from the corresponding triarylstannyl chlorides. They were fully characterized by IR and 1 H, 13 C, and 119 Sn NMR spectroscopy and mass spectrometry. Their solid-state structures and geometric parameters were determined and compared to those of other classes of thiocarbonylthio compounds. These new organotin derivatives are efficient reversible chain-transfer agents for reversible addition-fragmentation chain transfer (RAFT) polymerization of styrene (St) and n-butyl acrylate (BA), with controlled number-average molecular weights and narrow dispersities (Ð
Published: 2017

26. Enhanced Control of Phosphinoylcarbodithioate-Mediated RAFT Polymerization: Key Role of Substituents at the Phosphorus Center

Author: Stéphane Mazières, Mathias Destarac, Zoia Voitenko, Ihor Kulai, Interactions moléculaires et réactivité chimique et photochimique (IMRCP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Taras Shevchenko National University of Kyiv, Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Fédération de Recherche Fluides, Energie, Réacteurs, Matériaux et Transferts (FERMAT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), P3R - Polymères de Précision par Procédés Radicalaires (P3R), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT), and ANR-16-CE29-0014,RAFTSWITCH,Agents de Transfert RAFT Modulables pour la Polymérisation Radicalaire Contrôlée.(2016)
Subjects: chemistry.chemical_classification, Acrylate, Polymers and Plastics, Chemistry, Organic Chemistry, 02 engineering and technology, Raft, Polymer, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Styrene, Inorganic Chemistry, chemistry.chemical_compound, Polymerization, Polymer chemistry, Materials Chemistry, Proton NMR, Copolymer, [CHIM]Chemical Sciences, Reversible addition−fragmentation chain-transfer polymerization, 0210 nano-technology, ComputingMilieux_MISCELLANEOUS
Abstract: New phosphinoylcarbodithioate RAFT agents bearing dicyclohexyl- and di(piperidin-1-yl)phosphinoyl substituents were prepared, and their activity in RAFT polymerization of styrene and n-butyl acrylate was compared to that of previously reported diphenyl and bis(N,N-diisopropylamino) counterparts. Polymerizations were performed in deuterated solvent with quantitative 31P and 1H NMR monitoring. This approach allowed to study the polymer ω chain-end fidelity as well as RAFT agent transformations during the initialization period. It was also successfully applied for the monitoring of the block copolymerization. RAFT agents with cyclohexyl and piperidin-1-yl substituents bonded to the phosphorus center exhibited a marked improvement in the polymerization control with an optimal compromise between overall kinetics and control over molar masses and dispersities along with a significantly enhanced ω chain-end stability during polymerization.
Published: 2019

27. Don de sang : une approche territoriale

Author: Stéphane Mazières, Yannick Jaffré, Jacques Chiaroni, Bernard Cunéo, Pauline Oviedo, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), institut ViaVoice, Environnement, Santé, Sociétés (ESS), Centre National de la Recherche Scientifique (CNRS), and Etablissement Français du Sang Provence-Alpes Côte-d'Azur et Corse (EFS)
Subjects: 03 medical and health sciences, 0302 clinical medicine, Biochemistry (medical), Clinical Biochemistry, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, Hematology, 030204 cardiovascular system & hematology, ComputingMilieux_MISCELLANEOUS, 030215 immunology
Abstract: Pour que la securite transfusionnelle soit garantie, la diversite erythrocytaire des donneurs doit correspondre a celle des receveurs. Notre projet s’attache a promouvoir le don de sang dans les populations d’ancestralite africaine en reponse aux problematiques d’approvisionnement en produits sanguins compatibles consideres rares. Ces risques sont lies a une distribution preferentielle des groupes sanguins a travers le monde, a un maintien des migrations issues du continent africain et a une faible participation au don de ces populations etablies en France. Pour pallier ces difficultes, nous instaurons une approche territoriale au carrefour de l’anthropologie et de la geographie de la sante, marginale pour le don de sang. En accord avec la vision non communautaire des collectes pronee par l’EFS, cette approche apprehende le don sang dans le quotidien et les realites sociales des populations concernees. Notre terrain d’observation et d’action est le quartier populaire et commercant de Noailles (Marseille), zone densement peuplee ou convergent des vagues migratoires successives, notamment d’Afrique. Nos points de contact et de relais sont les lieux associes au bien-etre tels les salons de coiffure. Les notions de satisfaction et d’estime de soi sont associees aussi bien au bien-etre qu’au don de sang. La demarche de les associer peut donc etre socialement construite, et ainsi favoriser le contentement des besoins de sante publique identifies. A l’echelle du quartier, nous creerons un reseau de diffusion des informations aupres du public mais aussi de motivations et d’orientation de potentiels donneurs, afin que Noailles devienne un territoire du don, qui puisse faire ecole.
Published: 2019

28. Experimental and Theoretical Comparison of Addition–Fragmentation Pathways of Diseleno- and Dithiocarbamate RAFT Agents

Author: Dimitri Matioszek, Stéphane Mazières, Ching Yeh Lin, Oleksii Brusylovets, Simon Harrisson, Michelle L. Coote, Mathias Destarac, Interactions moléculaires et réactivité chimique et photochimique (IMRCP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), ARC Centre of Excellence in Free Radical Chemistry and Biotechnology, affiliation inconnue, Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Fédération de Recherche Fluides, Energie, Réacteurs, Matériaux et Transferts (FERMAT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), P3R - Polymères de Précision par Procédés Radicalaires (P3R), and Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT)
Subjects: chemistry.chemical_classification, Polymers and Plastics, Organic Chemistry, Chain transfer, 02 engineering and technology, Raft, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Adduct, Inorganic Chemistry, chemistry.chemical_compound, Monomer, chemistry, Fragmentation (mass spectrometry), Polymer chemistry, Materials Chemistry, Vinyl acetate, [CHIM]Chemical Sciences, Reactivity (chemistry), 0210 nano-technology, Dithiocarbamate, ComputingMilieux_MISCELLANEOUS
Abstract: Theoretical studies suggest that identically substituted dithio- and diselenocarbamate reversible addition–fragmentation chain transfer (RAFT) agents will have similar reactivity but that diselenocarbamate RAFT agents are more likely to undergo intermediate radical termination. These results are supported by an experimental study of polymerizations of vinyl acetate mediated by Se-cyanomethyl N,N-dimethyldiselenocarbamate (1Se) and its sulfur analog, S-cyanomethyl N,N-dimethyldithiocarbamate (1S). While the two polymerizations had similar interchain transfer constants (3.2 for 1S and 3.9 for 1Se), significant retardation was observed for 1Se-mediated polymerizations. External chain transfer constants were also measured for 1S (5.4) and 1Se (45). The low apparent value of the chain transfer constant of 1S is attributed to the selective formation of a single monomer adduct in the early stages of the reaction.
Published: 2019

29. ADN ancien et évolution humaine : nouveaux outils, nouvelles perspectives

Author: Stéphane Mazières, Caroline Costedoat, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), and Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0303 health sciences, 03 medical and health sciences, 02 engineering and technology, General Medicine, 021001 nanoscience & nanotechnology, 0210 nano-technology, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, [SHS]Humanities and Social Sciences
Abstract: International audience; Étonnamment, l’histoire de l’« ADN ancien » (noté parfois ADNa) est une histoire qui a commencé il y a juste 35 ans. C’est en effet, en 1984, au balbutiement de la biologie moléculaire, qu’une équipe californienne (Higuchi et al., 1984) parvient à cloner un fragment d’ADN d’un quagga, une sous-espèce de zèbre éteinte à la fin du XIXe siècle. Cette découverte revenait à dénicher alors l’impensable : des reliquats « vivants » (organiques) dans du non-vivant. Par cette ressuscitation in vitro de l’information génétique ancienne, la communauté scientifique mesurait alors le nouveau potentiel de cette découverte.
Published: 2019

30. Synthesis of S-Alkyl Phosphinocarbodithioates with Switch between P(III) and P(V) Derivatives

Author: Eric Manoury, Mathias Destarac, Jean-Claude Daran, Andrii Karpus, Stéphane Mazières, Rinaldo Poli, Laboratoire de chimie de coordination (LCC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Interactions moléculaires et réactivité chimique et photochimique (IMRCP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Centre National de la Recherche Scientifique (CNRS), ANR-16-CE29-0014,RAFTSWITCH,Agents de Transfert RAFT Modulables pour la Polymérisation Radicalaire Contrôlée.(2016), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Fédération de Recherche Fluides, Energie, Réacteurs, Matériaux et Transferts (FERMAT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), P3R - Polymères de Précision par Procédés Radicalaires (P3R), and Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT)
Subjects: chemistry.chemical_classification, Resonance structures, 010405 organic chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Organic Chemistry, Atom (order theory), Reaction products, Phosphorus, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Crystallography, chemistry, Oxidation state, Mixtures, Salts, Alkyl
Abstract: International audience; Simple and effective synthetic pathways are described to prepare compounds R2P(X)C(S)SCH(Me)Ph with the P atom either in the oxidation state V [R/X = t-Bu/O (6), Ph/S, (7), t-Bu/S (8), t-Bu/Se (9)] or III [R/X = Ph/BH3 (4), t-Bu/BH3 (5), t-Bu/lone pair (10)]. Compound 9 is the first example of carbodithioate ester with a P=Se group and for the first time a phosphinocarboditioate with a free phosphine function (compound 10) is described. Stabilization of the latter crucially depends on the steric protection by the t-Bu groups, since an analogous derivative with R = Ph is observable but too unstable for isolation. Compound 10 can be reversibly protonated to yield the [t-Bu2PHC(S)SCH(Me)Ph] + cation (10-H +), which was isolated as a BF4-salt. A few interconversion processes resulting in the facile addition/removal or exchange of the X group in this family of compounds are also described. The phosphorus atom oxidation state and the nature of electron-withdrawing group have a significant impact on the spectral properties.
Published: 2019

31. Manganese phosphinocarbodithioate for RAFT polymerisation with sunlight-induced chain end post-treatment

Author: Stéphane Mazières, Liubov Soroka, Ihor Kulai, Andrii Karpus, Dmitry A. Valyaev, Rinaldo Poli, Valérie Bourdon, Eric Manoury, Mathias Destarac, Interactions moléculaires et réactivité chimique et photochimique (IMRCP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Laboratoire de chimie de coordination (LCC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Service Commun de Spectrométrie de Masse (Toulouse, France), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, ANR-16-CE29-0014,RAFTSWITCH,Agents de Transfert RAFT Modulables pour la Polymérisation Radicalaire Contrôlée.(2016), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Fédération de Recherche Fluides, Energie, Réacteurs, Matériaux et Transferts (FERMAT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), P3R - Polymères de Précision par Procédés Radicalaires (P3R), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), and Université de Toulouse (UT)-Université de Toulouse (UT)
Subjects: chemistry.chemical_classification, Polymers and Plastics, Diphenylphosphine, Organic Chemistry, chemistry.chemical_element, Infrared spectroscopy, Bioengineering, 02 engineering and technology, Raft, Manganese, Polymer, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Biochemistry, Coupling reaction, 0104 chemical sciences, chemistry.chemical_compound, [CHIM.POLY]Chemical Sciences/Polymers, chemistry, Polymerization, Polymer chemistry, Copolymer, [CHIM.COOR]Chemical Sciences/Coordination chemistry, 0210 nano-technology
Abstract: International audience; A new manganese RAFT agent of the formula Cp(CO)(2)MnP(Ph)(2)C(?S)SCH(CH3)Ph was synthesized in a good overall yield by a three-step reaction from cymantrene and diphenylphosphine as the main starting materials. This complex proved to be efficient for the control of RAFT polymerisation of St, n-BA and DMAAm. The reaction course could be conveniently monitored by P-31 NMR spectroscopy. The controlled character of these polymerisations and the integrity of the polymer chain ends were demonstrated by the synthesis of diblock copolymers of St and n-BA. In the case of long polymerisation times (i.e. for PSt), photo-induced polymer chain coupling reactions were detected. Importantly, removal of the Mn-RAFT--chain end by visible light irradiation led to the formation of a monomodal SH-terminated PSt. These phenomena were evidenced by IR spectroscopy, SEC with RI and UV detection modes and by ESI mass spectrometry.
Published: 2019

32. Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe

Author: Simona Barlera, Giovanni Birolo, Simon Myers, Viola Grugni, Vincenzo Lorenzo Pascali, Andrea Angius, Mait Metspalu, Francesca Brisighelli, Antonio Torroni, Francesco Montinaro, Hovirag Lancioni, Luísa Pereira, Antonella Mulas, Mohammed Melhaoui, Alessandro Achilli, Serena Aneli, Mohammed Cherkaoui, Peristera Paschou, M. Peyret-Guzzon, Pilar Galan, Giorgio B. Boncoraglio, A. M. Di Blasio, Stéphane Mazières, C. Di Gaetano, Garrett Hellenthal, Giuseppe Matullo, George Stamatoyannopoulos, Joanna Giemza, J. Di Cristofaro, Magdalena Zoledziewska, Irene Cardinali, Georgios Athanasiadis, Cristian Capelli, François-Xavier Ricaut, Jacques Chiaroni, Anna Olivieri, Alessandro Raveane, Luca Pagani, Toomas Kivisild, Abdellatif Baali, Nicolas Brucato, Christian Dina, Jean-Michel Dugoujon, Clare Bycroft, Alberto Piazza, Silvia Parolo, Francesco Cucca, Ornella Semino, Dipartimento di Biologia e Biotecnologie ‘Lazzaro Spallanzani’, University of Pavia, University of Pavia, University of Oxford [Oxford], Aarhus University [Aarhus], Istituto di Ricerche Farmacologiche Mario Negri, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Fondazione 'Istituto Neurologico Nazionale C. Mondino'-Fondazione 'Istituto Neurologico Nazionale C. Mondino', University of Turin, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Dipartimento di Genetica, Biologica e Biochimica, Università degli studi di Torino (UNITO), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique (LERMA), École normale supérieure - Paris (ENS Paris)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Centre National de la Recherche Scientifique (CNRS), Georgia Tech - CNRS [Metz] (UMI2958), Ecole Nationale Supérieure des Arts et Metiers Metz-SUPELEC-Georgia Institute of Technology [Atlanta]-Georgia Institute of Technology [Lorraine, France]-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Etablissement Français du Sang - Alpes-Méditerranée (EFS - Alpes-Méditerranée), Etablissement Français du Sang, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Génétique des maladies multifactorielles (GMM), Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Sorbonne Paris Cité (USPC)-Université Paris 13 (UP13)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut National de la Recherche Agronomique (INRA), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Centre National de la Recherche Scientifique (CNRS), Dipartimento di Genetica e Microbiologica, Università di Pavia, Dipartimento di Genetica e Microbiologia, Instituto de Investigação e Inovação em Saúde, Raveane, A, Aneli, S, Montinaro, F, Athanasiadis, G, Barlera, S, Birolo, G, Boncoraglio, G, Di Blasio, A, Di Gaetano, C, Pagani, L, Parolo, S, Paschou, P, Piazza, A, Stamatoyannopoulos, G, Angius, A, Brucato, N, Cucca, F, Hellenthal, G, Mulas, A, Peyret-Guzzon, M, Zoledziewska, M, Baali, A, Bycroft, C, Cherkaoui, M, Chiaroni, J, Di Cristofaro, J, Dina, C, Dugoujon, J, Galan, P, Giemza, J, Kivisild, T, Mazieres, S, Melhaoui, M, Metspalu, M, Myers, S, Pereira, L, Ricaut, F, Brisighelli, F, Cardinali, I, Grugni, V, Lancioni, H, Pascali, V, Torroni, A, Semino, O, Matullo, G, Achilli, A, Olivieri, A, Capelli, C, Mazières, Stéphane, Dipartimento di Biologia e Biotecnologie 'Lazzaro Spallanzani' = Department of Biology and Biotechnology [Univ di Pavia] (DBB UNIPV), Università degli Studi di Pavia = University of Pavia (UNIPV), University of Oxford, Università degli studi di Torino = University of Turin (UNITO), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université de Cergy Pontoise (UCP), Georgia Tech Lorraine [Metz], Ecole Nationale Supérieure des Arts et Metiers Metz-Georgia Institute of Technology [Atlanta]-Ecole Supérieure d'Electricité - SUPELEC (FRANCE)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), École normale supérieure - Paris (ENS Paris), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Sorbonne Paris Cité (USPC)-Université Paris 13 (UP13)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université (HESAM)-HESAM Université (HESAM)-Institut National de la Recherche Agronomique (INRA), HESAM Université (HESAM)-HESAM Université (HESAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Università degli Studi di Pavia, Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Paris 13 (UP13)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), and Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: SELECTION, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, Distribution (economics), Population genetics, Neanderthal genome project, 0302 clinical medicine, Peninsula, HISTORY, Databases, Genetic, ADAPTATION, Research Articles, History, Ancient, media_common, Neanderthals, MODERN HUMANS, 0303 health sciences, Multidisciplinary, geography.geographical_feature_category, POPULATION GENETICS, GENOMICS, EUROPE, Population Genetic, SciAdv r-articles, ASSOCIATION, [SHS.ANTHRO-BIO] Humanities and Social Sciences/Biological anthropology, Multidisciplinary Sciences, ADMIXTURE, Geography, Italy, Ethnology, Science & Technology - Other Topics, Neanderthals / genetics, Research Article, EUROPE, MIGRATION, media_common.quotation_subject, Pastoralism, Human Genetic, Settore BIO/08 - ANTROPOLOGIA, GENETIC-STRUCTURE, SEQUENCE, White People, 03 medical and health sciences, Bronze Age, POPULATION GENETICS, Genetic variation, Animals, Humans, DNA, Ancient, European Continental Ancestry Group / genetics, 030304 developmental biology, Science & Technology, business.industry, Genome, Human, Genetic Drift, Human Genetics, Anthropology, GENOME-WIDE PATTERNS, business, GENOMICS, 030217 neurology & neurosurgery, Diversity (politics), Genome-Wide Association Study
Abstract: A population in a natural crossroad within Europe reveals multiple ancient contributions and substantial population structure., European populations display low genetic differentiation as the result of long-term blending of their ancient founding ancestries. However, it is unclear how the combination of ancient ancestries related to early foragers, Neolithic farmers, and Bronze Age nomadic pastoralists can explain the distribution of genetic variation across Europe. Populations in natural crossroads like the Italian peninsula are expected to recapitulate the continental diversity, but have been systematically understudied. Here, we characterize the ancestry profiles of Italian populations using a genome-wide dataset representative of modern and ancient samples from across Italy, Europe, and the rest of the world. Italian genomes capture several ancient signatures, including a non–steppe contribution derived ultimately from the Caucasus. Differences in ancestry composition, as the result of migration and admixture, have generated in Italy the largest degree of population structure detected so far in the continent, as well as shaping the amount of Neanderthal DNA in modern-day populations.
Published: 2019

33. Le panorama du Paléolithique supérieur vu par les groupes sanguins

Author: Stephane Mazières, Silvana Condemi, Wassim El Nemer, and Jacques Chiaroni
Subjects: History of Civilization, CB3-482
Published: 2023

34. Polymorphisme des systèmes de groupe sanguin en Papouasie Nouvelle-Guinée

Author: Benjamin Tournan, Adeline Morez, Stephane Mazières, Christopher Kinipi, Matthew Leavesley, Nicolas Brucato, and François-Xavier Ricaut
Subjects: History of Civilization, CB3-482
Published: 2023

35. Publisher Correction: Genome-wide analysis of Corsican population reveals a close affinity with Northern and Central Italy

Author: Erwan Pennarun, Luísa Pereira, Francesco Montinaro, Stéphane Mazières, Mait Metspalu, Jacques Chiaroni, Ornella Semino, Alessandro Raveane, Erika Tamm, Alena Kushniarevich, and Julie Di Cristofaro
Subjects: education.field_of_study, Multidisciplinary, Population, lcsh:R, Genome wide analysis, lcsh:Medicine, Biology, language.human_language, Evolutionary biology, language, lcsh:Q, education, lcsh:Science, Corsican
Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Published: 2019

36. Quench ionic flash nano precipitation as a simple and tunable approach to decouple growth and functionalization for the one-step synthesis of functional LnPO

Author: Nathalie M, Pinkerton, Khadidja, Hadri, Baptiste, Amouroux, Leah, Behar, Christophe, Mingotaud, Mathias, Destarac, Ihor, Kulai, Stéphane, Mazières, Stefan, Chassaing, and Jean-Daniel, Marty
Abstract: A novel, one-step method for the synthesis of functional, organic-inorganic hybrid nanoparticles is reported. The quench ionic Flash NanoPrecipitation (qiFNP) method enables the straightforward synthesis of nanoparticles by decoupling the formation of the inorganic core and surface functionalization. As a proof-of-concept, the qiFNP method was successfully applied for the tunable and highly controlled synthesis of various LnPO4-based nanomaterials for bioimaging applications.
Published: 2018

37. The radial expansion of the Diego blood group system polymorphisms in Asia: mark of co-migration with the Mongol conquests

Author: Florence, Petit, Francesca, Minnai, Jacques, Chiaroni, Peter A, Underhill, Pascal, Bailly, Stéphane, Mazières, and Caroline, Costedoat
Subjects: Male, Asia, Chromosomes, Human, Y, Polymorphism, Genetic, Asian People, Haplotypes, Anion Exchange Protein 1, Erythrocyte, Human Migration, Humans, Female, Article
Abstract: Red cell polymorphisms can provide evidence of human migration and adaptation patterns. In Eurasia, the distribution of Diego blood group system polymorphisms remains unaddressed. To shed light on the dispersal of the Dia antigen, we performed analyses of correlations between the frequencies of DI*01 allele, C2-M217 and C2-M401 Y-chromosome haplotypes ascribed as being of Mongolian-origin and language affiliations, in 75 Eurasian populations including DI*01 frequency data from the HGDP-CEPH panel. We revealed that DI*01 reaches its highest frequency in Mongolia, Turkmenistan and Kyrgyzstan, expanding southward and westward across Asia with Altaic-speaking nomadic carriers of C2-M217, and even more precisely C2-M401, from their homeland presumably in Mongolia, between the third century BCE and the thirteenth century CE. The present study has highlighted the gene-culture co-migration with the demographic movements that occurred during the past two millennia in Central and East Asia. Additionally, this work contributes to a better understanding of the distribution of immunogenic erythrocyte polymorphisms with a view to improve transfusion safety.
Published: 2018

38. The Comoros Show the Earliest Austronesian Gene Flow into the Swahili Corridor

Author: Jacques Chiaroni, Mohammed Omar, Murray P. Cox, Bertrand Fin, Stéphane Mazières, Farida Alshamali, Anne Boland, Pradiptajati Kusuma, Nicole Boivin, Marie-Claude Simeone-Senelle, Joseph Wainaina Ng’ang’a, Pascal Bailly, Alison Crowther, Alexander Adelaar, François-Xavier Ricaut, Mark Stoneking, Luísa Pereira, Nicolas Brucato, Jean-François Deleuze, Verónica Fernandes, Coralie Frassati, Instituto de Investigação e Inovação em Saúde, Human Genetics, Instituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Anthropologie Moléculaire et Imagerie de Synthèse (AMIS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Langage, LAngues et Cultures d'Afrique Noire (LLACAN), Institut National des Langues et Civilisations Orientales (Inalco)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Etablissement Français du Sang - Alpes-Méditerranée (EFS - Alpes-Méditerranée), Etablissement Français du Sang, Dubai Police General Headquarters, Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Evolutionary Genetics, University of Oxford [Oxford], Archaeogenetics Laboratory, Sorenson Molecular Genealogy Foundation, Universidade do Porto = University of Porto, Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), and University of Oxford
Subjects: 0301 basic medicine, Gene Flow, Asia, Population, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, Population genetics, Bantu languages, Admixture, 030105 genetics & heredity, migration, Polymorphism, Single Nucleotide, Article, Comoros, Gene flow, 03 medical and health sciences, Genetics, Madagascar, Humans, education, Genetics (clinical), Migration, Swahili, education.field_of_study, geography.geographical_feature_category, Middle East, Australia, population genetics, Genetic Variation, Kenya, East Africa, language.human_language, 030104 developmental biology, Geography, Genetics, Population, Archipelago, language, Ethnology, Biological dispersal, admixture, Population Genetics
Abstract: At the dawn of the second millennium, the expansion of the Indian Ocean trading network aligned with the emergence of an outward-oriented community along the East African coast to create a cosmopolitan cultural and trading zone known as the Swahili Corridor. On the basis of analyses of new genome-wide genotyping data and uniparental data in 276 individuals from coastal Kenya and the Comoros islands, along with large-scale genetic datasets from the Indian Ocean rim, we reconstruct historical population dynamics to show that the Swahili Corridor is largely an eastern Bantu genetic continuum. Limited gene flows from the Middle East can be seen in Swahili and Comorian populations at dates corresponding to historically documented contacts. However, the main admixture event in southern insular populations, particularly Comorian and Malagasy groups, occurred with individuals from Island Southeast Asia as early as the 8th century, reflecting an earlier dispersal from this region. Remarkably, our results support recent archaeological and linguistic evidence-based suggestions that the Comoros archipelago was the earliest location of contact between Austronesian and African populations in the Swahili Corridor. We acknowledge support from the GenoToul bioinformatics facility of Genopole Toulouse Midi-Pyre´ne´es, France. This research was supported by French Ministry of Research grant ANR-14-CE31-0013-01 (OCEOADAPTO) to F.-X.R, a Rutherford Fellowship from the Royal Society of New Zealand (RDF-10- MAU-001), a fellowship from the Alexander von Humboldt Foundation to M.P.C., and grants from COMPETE 2020 and a Fundac¸a˜o para a Cieˆncia e a Tecnologia-funded project (POCI-01-0145-FEDER-016609) to V.F. We thank Kamil Merito for his help collecting East African samples. We thank all the local Swahili and Comorian communities who participated in this study.
Published: 2018

39. Prehistoric migrations through the Mediterranean basin shaped Corsican Y-chromosome diversity

Author: Jacques Chiaroni, Alice A. Lin, Cornelia Di Gaetano, Peter A. Underhill, Paul Nebbia, Julie Di Cristofaro, Stéphane Mazières, Audrey Tous, Roy J. King, Alberto Piazza, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Etablissement Français du Sang - Alpes-Méditerranée (EFS - Alpes-Méditerranée), Etablissement Français du Sang, École des hautes études en sciences sociales (EHESS), Department of Psychiatry and Behavioral Sciences [Stanford], Stanford Medicine, Stanford University-Stanford University, Department of Genetics [Stanford], UMR 6578 : Anthropologie Bio-Culturelle (UAABC), and Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Topography, Population genetics, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, lcsh:Medicine, Stone Age, 030105 genetics & heredity, Haplogroup, Geographical locations, Gene Frequency, Y chromosomes, lcsh:Science, Phylogeny, Islands, Principal Component Analysis, Multidisciplinary, Sex Chromosomes, Ecology, Chromosome Biology, Mediterranean Region, Paleogenetics, Geology, Neolithic period, Europe, Geography, Italy, language, France, Research Article, Mesolithic period, Human Migration, Genetic relationship, Polymorphism, Single Nucleotide, Chromosomes, White People, 03 medical and health sciences, Genetic variation, Genetics, Humans, European Union, Mesolithic, Genetic diversity, Evolutionary Biology, Landforms, Chromosomes, Human, Y, Population Biology, lcsh:R, Biology and Life Sciences, Paleontology, Genetic Variation, Geologic Time, Geomorphology, Cell Biology, language.human_language, 030104 developmental biology, Haplotypes, Earth Sciences, Haplogroups, lcsh:Q, People and places, Corsican
Abstract: International audience; The rarity of human remains makes it difficult to apprehend the first settlements in Corsica. It is admitted that initial colonization could have occurred during the Mesolithic period when glaciations would have shortened the open water travel distance from the continent. Meso-lithic sites in Corsica show relatively short and irregular occupation, and suggest discontinu-ous settling of very mobile groups probably traveling by boat. Previous genetic studies on Corsican populations showed internal differentiation and a relatively poor genetic relationship with continental populations, despite intense historical contacts, however local Meso-lithic-based genetic inheritance has never been properly estimated. The aim of this study was to explore the Corsican genetic profile of Y-chromosomes in order to trace the genetic signatures back to the first migrations to Corsica. This study included 321 samples from men throughout Corsica; samples from Provence and Tuscany were added to the cohort. All samples were typed for 92 Y-SNPs, and Y-STRs were also analyzed. Results revealed highly differentiated haplogroup patterns among Corsican populations. Haplogroup G had the highest frequency in Corsica, mostly displaying a unique Y-STR profile. When compared with Provence and Tuscany, Corsican populations displayed limited genetic proximity. Cor-sican populations present a remarkable Y-chromosome genetic mixture. Although the Cor-sican Y-chromosome profile shows similarities with both Provence and to a lesser extent Tuscany, it mainly displays its own specificity. This study confirms the high level of genetic diversity in Corsican populations and backs genetic contributions from prehistoric migrations associated with the Mesolithic, Neolithic and Metal Age eras, rather than from historical movements to Corsica, respectively attested by frequencies and TMRCA of haplogroups G2a-L91 and G2a-P15, J2a-M241 and J2-DYS445 = 6, R1b-U152 and R1b-U106. These results suggest that marine routes to reach the Corsican coast in many different points may have led to such a genetic heterogeneity.
Published: 2018

40. Genes flow by the channels of culture: the genetic imprint of matrilocality in Ngazidja, Comoros Islands

Author: Stéphane Mazières, Pascal Bailly, Jacques Chiaroni, Caroline Costedoat, Célia Kamel, Pauline Oviedo, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Etablissement Français du Sang - Alpes-Méditerranée (EFS - Alpes-Méditerranée), and Etablissement Français du Sang
Subjects: 0301 basic medicine, Gene Flow, Male, Human Migration, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, Population, 030105 genetics & heredity, Biology, Brief Communication, DNA, Mitochondrial, Gene flow, 03 medical and health sciences, Genomic Imprinting, Indian Ocean Islands, Genetic variation, Genetics, Humans, education, ComputingMilieux_MISCELLANEOUS, Genetics (clinical), education.field_of_study, Genetic diversity, Chromosomes, Human, Y, Polymorphism, Genetic, 030104 developmental biology, Evolutionary biology, Genetic structure, Biological dispersal, Matrilocal residence, Microsatellite, Female, Microsatellite Repeats
Abstract: Post-marital residence of spouses is one of the architects of population genetic structure. In the present study, we tested how the place of residence of males and females in Ngazidja, Comoros Islands, has unequally channeled, by dispersal among villages, the male and female genetic diversity. Using sequences of the hypervariable segment I of the mitochondrial DNA (mtDNA HVS-I) and six Y-chromosome microsatellites (Y-STRs), we measured the genetic variation and male-to-female effective number of migrants ratios based on FST values and revealed a genetic structure mostly driven by male gene flow across villages. This genetic feature illustrates the uxori-matrilocality inherited from the Bantu expansion, though one exception exists in Bandamadji whose historically documented military status implied patrilocality in this locality.
Published: 2017

41. Reversible addition-fragmentation chain-transfer polymerization of vinyl monomers with N,N- dimethyldiselenocarbamates

Author: Oleksii Brusylovets, Dimitri Matioszek, Mathias Destarac, D. James Wilson, and Stéphane Mazières
Subjects: Polymers and Plastics, Chemistry, Organic Chemistry, Chain transfer, Photochemistry, Ring-opening polymerization, Vinyl polymer, Living free-radical polymerization, Anionic addition polymerization, Catalytic chain transfer, Polymer chemistry, Materials Chemistry, Living polymerization, Reversible addition−fragmentation chain-transfer polymerization
Published: 2013

42. Blood group typing in five Afghan populations in the North Hindu-Kush region: implications for blood transfusion practice

Author: H. Vasseur, Jacques Chiaroni, Stéphane Mazières, S. A. Temory, J. Di Cristofaro, and P. Gallian
Subjects: Genetics, 0303 health sciences, Blood transfusion, medicine.medical_treatment, Ethnic group, Hematology, 030204 cardiovascular system & hematology, Biology, 03 medical and health sciences, 0302 clinical medicine, Afghan, ABO blood group system, Genotype, medicine, Typing, Allele, Allele frequency, 030304 developmental biology
Abstract: Summary Background and Objectives Blood incompatibility arises from individual and ethnic differences in red blood cell (RBC) antigen profiles. This underlines the importance of documenting RBC antigen variability in various ethnic groups. Central Asia is an area with a long and complex migratory history. The purpose of this article is to describe key antigen frequencies of Afghan ethnic groups in the Hindu-Kush region of Afghanistan as a basis for improving blood transfusion practices in that area. Materials and Methods The key ABO, Rh and Kell antigens were investigated in five Afghan populations. In order to depict accurately the blood group gene diversity in the area, DNA from eight additional Pakistani populations were included, and the entire sample set screened using two multiplex polymerase chain reactions sensitive for 17 alleles in 10 blood group genetic systems (MNS, Kell, Duffy, Kidd, Cartwright, Dombrock, Indian, Colton, Diego and Landsteiner–Wiener). Results Phenotype and allele frequencies fell within the ranges observed in Western European and East Asian populations. Occurrence of DI*01, IN*01, LW*07 and FY*02N.01 and prevalence of ABO*B were consistent with migratory history as well as with putative environmental adaptation in the subtropical environment Hindu-Kush region. Conclusion These findings expand the current knowledge about key antigen frequencies. Regarding occurrence of viral markers, further blood transfusion in the region requires rigorous typing.
Published: 2013

43. Germylene and (Diazomethyl)germylene Complexes – Potential Precursors for a Transition‐Metal–Germa‐Alkyne Complex

Author: Nathalie Saffon-Merceron, Stéphane Mazières, Eric Bonnefille, and Claude Couret
Subjects: chemistry.chemical_classification, Trimethylsilyl, Photodissociation, Alkyne, chemistry.chemical_element, Nuclear magnetic resonance spectroscopy, Tungsten, Photochemistry, Inorganic Chemistry, chemistry.chemical_compound, chemistry, Polymer chemistry, Moiety, Trimethylsilyldiazomethane, Tetrahydrofuran
Abstract: The synthesis and characterization of chlorogermylenes and (diazomethyl)germylenes involving the germanium atom coordinated to a tungsten pentacarbonyl group are reported. Treatment of chlorogermylene 1 with pentacarbonyl(tetrahydrofuran) tungsten led to chlorogermylene complex 2 in good yield. A similar reaction with (diazomethyl)germylene 3 gave complex 4, which rapidly lost the trimethylsilyl moiety to generate tungsten complex 5. Otherwise, complex 5 was obtained directly by reaction of the lithium salt of trimethylsilyldiazomethane with complex 2. Complexes 2 and 5 were fully characterized by NMR spectroscopy, mass spectrometry, and X-ray crystallography. The photolysis of 5 was studied with the aim of generating a germa-alkyne complex.
Published: 2012

44. SI-RAFT/MADIX polymerization of vinyl acetate on cellulose nanocrystals for nanocomposite applications

Author: Stéphane Mazières, Mathias Destarac, Assya Boujemaoui, Anna Carlmark, Eva Malmström, Interactions moléculaires et réactivité chimique et photochimique (IMRCP), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Fédération de Recherche Fluides, Energie, Réacteurs, Matériaux et Transferts (FERMAT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), P3R - Polymères de Précision par Procédés Radicalaires (P3R), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT), Royal Institute of Technology, Royal Institute of Technology [Stockholm] (KTH ), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)
Subjects: Nanocomposite, Materials science, Polymers and Plastics, Surface initiated, Organic Chemistry, Chain transfer, 02 engineering and technology, Raft, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 3. Good health, 0104 chemical sciences, Cellulose nanocrystals, chemistry.chemical_compound, chemistry, Polymerization, Polymer chemistry, Materials Chemistry, Vinyl acetate, [CHIM]Chemical Sciences, 0210 nano-technology, ComputingMilieux_MISCELLANEOUS, Macromolecule
Abstract: In the present work, poly(vinyl acetate) grafted cellulose nanocrystals (CNC-g-PVAc) were prepared via surface initiated reversible addition-fragmentation chain transfer and macromolecular design v ...
Published: 2016

45. 'The ecstasy of copper' : l'héritage des expansions néolithiques et de l'âge du Bronze dans le patrimoine génétique chypriote actuel

Author: Konstantinos Voskarides, Stéphane Mazières, Despina Hadjipanagi, Julie Di Cristofaro, Anastasia Ignatiou, Charalambos Stefanou, Roy King, Peter Underhill, Jacques Chiaroni, Constantinos Deltas, Molecular Medicine Research Center, Laboratory of Molecular and Medical Genetics, University of Cyprus, Molecular Medicine Research Center and Laboratory of Molecular and Medical Genetics, Department of Biological Sciences, University of Cyprus, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Etablissement Français du Sang - Alpes-Méditerranée (EFS - Alpes-Méditerranée), Etablissement Français du Sang, Department of Psychiatry and Behavioral Sciences [Stanford], Stanford Medicine, Stanford University-Stanford University, and Department of Genetics [Stanford]
Subjects: Age du Bronze, chromosome Y, Chypre, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, Néolithique, ComputingMilieux_MISCELLANEOUS
Abstract: National audience
Published: 2016

46. The Hmong Diaspora: Preserved South-East Asian genetic ancestry in French Guianese Asians

Author: Evelyne Guitard, Pierre-Henri Giscard, Georges Larrouy, Stéphane Mazières, Jean-Michel Dugoujon, Etienne Bois, Nicolas Brucato, Human Genetics, Anthropologie Moléculaire et Imagerie de Synthèse (AMIS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Institut des Déserts et des Steppes, Centre de Coopération Scientifique et Culturelle Europe-Asie EURASIAT, Programme AMAZONIE - Analyse, modélisation et ingénierie des systèmes amazoniens (programme interdisciplinaire du CNRS), Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Human Migration, Genetic genealogy, Population, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, DNA, Mitochondrial, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Diaspora, 03 medical and health sciences, Asian People, Gene Frequency, Ethnicity, Humans, 0601 history and archaeology, education, Asia, Southeastern, 030304 developmental biology, Chromosomes, Human, X, 0303 health sciences, Genetic diversity, education.field_of_study, 060101 anthropology, General Immunology and Microbiology, Human migration, business.industry, Genetic Variation, Gene Pool, 06 humanities and the arts, General Medicine, French Guiana, Metropolitan France, Geography, Haplotypes, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Tandem Repeat Sequences, Data Interpretation, Statistical, Immunoglobulin G, Ethnology, Gene pool, General Agricultural and Biological Sciences, business, Founder effect
Abstract: International audience; The Hmong Diaspora is one of the widest modern human migrations. Mainly localised in South-East Asia, the United States of America, and metropolitan France, a small community has also settled the Amazonian forest of French Guiana. We have biologically analysed 62 individuals of this unique Guianese population through three complementary genetic markers: mitochondrial DNA (HVS-I/II and coding region SNPs), Y-chromosome (SNPs and STRs), and the Gm allotypic system. All genetic systems showed a high conservation of the Asian gene pool (Asian ancestry: mtDNA=100.0%; NRY=99.1%; Gm=96.6%), without a trace of founder effect. When compared across various Asian populations, the highest correlations were observed with Hmong-Mien groups still living in South-East Asia (Fst
Published: 2012

47. Aqueous RAFT/MADIXpolymerisation of N-vinyl pyrrolidone at ambient temperature

Author: Stéphane Mazières, Mathias Destarac, D. James Wilson, and Aymeric Guinaudeau
Subjects: Aqueous solution, Polymers and Plastics, Chemistry, Organic Chemistry, technology, industry, and agriculture, Bioengineering, Raft, Ascorbic acid, Mass spectrometry, Biochemistry, Redox, Polymerization, Homogeneous, Polymer chemistry, Copolymer
Abstract: The RAFT/MADIX polymerisation of N-vinyl pyrrolidone was successfully carried out in homogeneous water medium at 25 °C using the tert-butyl hydroperoxide/ascorbic acid redox initiator. The controlled character of the polymerisation was confirmed by MALDI-TOF mass spectrometry, SEC and NMR analyses. This finding paves the way for the preparation of novel all-hydrophilic complex copolymer architectures based on poly(N-vinyl pyrrolidone).
Published: 2012

48. New substituents for the stabilization of low-coordinate germanium species: Use in access to diazogermylenes

Author: Oleksii Brusylovets, Stéphane Mazières, Oleg V. Vinichenko, Anatoliy I. Brusilovets, Claude Couret, Eric Bonnefille, and Tadeusz Lis
Subjects: Trimethylsilyl, Chemistry, Stereochemistry, Diastereomer, chemistry.chemical_element, Germanium, Medicinal chemistry, law.invention, Ion, Inorganic Chemistry, chemistry.chemical_compound, law, Materials Chemistry, Alkoxy group, Physical and Theoretical Chemistry, Crystallization, Trimethylsilyldiazomethane, Benzene
Abstract: The reactions of the P-bis(trimethylsilyl)amino-N-(trimethylsilyl)iminophosphine with various dialkoxydichlorogermanes (alkoxy: OR = OMe, OEt and Oi-Pr) at 0 °C led to the stable dichlorogermylene-complexes [(RO)2P(NSiMe3)(N(SiMe3)2)]GeCl2 [R = Me (1), Et (2) and R = i-Pr (3)]. The solid-state structure of (2) has been determined by X-ray crystallography. A mechanism for the formation of these compounds is proposed, based on the transient species observed in the case of the isopropoxy derivatives. At room temperature in benzene solution, compounds (1) and (2) eliminate chlorotrimethylsilane without side reactions leading to the corresponding 2,4-diaza-3-phosphagermatidines [(RO)2P(NSiMe3)2]GeCl (4) and (5), respectively. At the opposite, complex (3) showed a modulated behavior: at room temperature, (3) still slowly eliminates mainly chlorotrimethylsilane with the formation of [(i-PrO)2P(NSiMe3)2]GeCl (6). Structure of this chlorinated germanium(II) compound which can also be seen as a germyl anion has been evidenced by an X-ray analysis. But at higher temperature (40–50 °C) (3) mainly decomposes with elimination of isopropylchloride leading to the formation of [(i-PrO)(Me3SiO)P(NSiMe3)2]GeCl (7) as a mixture of Z- and E-isomers. The mechanism of this reaction is discussed. The Z-isomer of (7) was successfully isolated after a selective crystallization, and investigated by an X-ray analysis. The interconversion mechanism of the two diastereoisomers is also discussed. Reaction of compound (5) with the lithio derivative of the trimethylsilyldiazomethane leads to the diazogermylene (8), a potential precursor of germa-alkyne.
Published: 2010

49. Aqueous MADIX/RAFT polymerization of diallyldimethylammonium chloride: Extension to the synthesis of poly(DADMAC)-based double hydrophilic block copolymers

Author: Roland Geagea, Samy Chadel, Stéphane Mazières, Cecile Boutin, James Wilson, Eric van Gramberen, Aymeric Guinaudeau, and Mathias Destarac
Subjects: Polymers and Plastics, Chemistry, Organic Chemistry, Dispersity, Cationic polymerization, Chain transfer, chemistry.chemical_compound, Monomer, Polymerization, Polymer chemistry, Materials Chemistry, Copolymer, Reversible addition−fragmentation chain-transfer polymerization, Xanthate
Abstract: Macromolecular design by interchange of xanthates/reversible addition fragmentation chain transfer polymerization (MADIX/RAFT) of diallyldimethylammonium chloride (DADMAC) using the hydrophobic O-ethyl-S-(1-methoxycarbonyl) ethyl dithiocarbonate MADIX/RAFT mediating agent, Rhodixan A1, was investigated. Attempts to obtain an efficient control of DADMAC polymerization in a water/ethanol mixture failed because of significant chain transfer to ethanol. The use of a water-soluble Rhodixan A1-terminated acrylamide oligomer as the MADIX/RAFT agent enabled the controlled polymerization of DADMAC in water at 50 °C using the cationic azo initiator V-50. An excellent agreement was found between experimental and theoretical Mn values throughout polymerization and over a broad range of initial concentration of xanthate. Polydispersity indexes (PDIs) at the end of the polymerization were abnormally high for a process showing a linear increase of Mn with monomer conversion (1.8 < PDI < 2.0). This feature was explained by the measurement of a high transfer constant to xanthate (Cx = 18.8 ± 1.6) but a low interchange transfer constant (Cex = 1.5). Nevertheless, poly(acrylamide)–poly(DADMAC) double hydrophilic block copolymers (DHBCs) of controlled Mn and composition could be successfully synthesized for the first time. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010
Published: 2010

50. Contrasting Patterns of Nuclear and mtDNA Diversity in Native American Populations

Author: M. W. Burley, Luiza T. Tsuneto, Claudio M. Bravi, Francisco Rothhammer, Jean-Michel Dugoujon, Stéphane Mazières, Andres Ruiz-Linares, Ramiro Barrantes, Gabriel Bedoya, Ning Ning Yang, María Victoria Parra, Julio Molina, William Klitz, Maria Cátira Bortolini, Elena Llop, Winston Rojas, Giovanni Poletti, Damian Labuda, Nicolas Ray, Carla Gallo, Maria Luiza Petzl-Erler, Kim Hill, Francisco M. Salzano, Sijia Wang, Laurent Excoffier, and A. M. Hurtado
Subjects: Genetics, 0303 health sciences, Mitochondrial DNA, education.field_of_study, 060101 anthropology, Effective size, Demographic history, Ecology, Native american, Population, Population structure, 06 humanities and the arts, 03 medical and health sciences, Geography, Microsatellite, 0601 history and archaeology, Colonization, education, Genetics (clinical), 030304 developmental biology
Abstract: We report an integrated analysis of nuclear (autosomal, X- and Y-chromosome) short tandem repeat (STR) data and mtDNA D-loop sequences obtained in the same set of 22 Native populations from across the Americas. A north to south gradient of decreasing population diversity was observed, in agreement with a settlement of the Americas from the extreme northwest of the continent. This correlation is stronger with "least cost distances," which consider the coasts as facilitators of migration. Continent-wide estimates of population structure are highest for the Y-chromosome and lowest for the autosomes, consistent with the effective size of the different marker systems examined. Population differentiation is highest in East South America and lowest in Meso America and the Andean region. Regional analyses suggest a deviation from mutation-drift equilibrium consistent with population expansion in Meso America and the Andes and population contraction in Northwest and East South America. These data hint at an early divergence of Andean and non-Andean South Americans and at a contrasting demographic history for populations from these regions.
Published: 2010

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