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109 results on '"Stack W"'

1. Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease

Author

Ryan, F. J., Ahern, A. M., Fitzgerald, R. S., Laserna-Mendieta, E. J., Power, E. M., Clooney, A. G., O’Donoghue, K. W., McMurdie, P. J., Iwai, S., Crits-Christoph, A., Sheehan, D., Moran, C., Flemer, B., Zomer, A. L., Fanning, A., O’Callaghan, J., Walton, J., Temko, A., Stack, W., Jackson, L., Joyce, S. A., Melgar, S., DeSantis, T. Z., Bell, J. T., Shanahan, F., and Claesson, M. J.

Published
2020
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3. Irish society of gastroenterology: Proceedings of Winter Meeting held 4th/5th December 1992in Beaumont hospital, Dublin

Author

O’Sullivan, M., Thornton, G., O’Sullivan, G., O’Mahony, A. M., O’Connell, J., Hanvajanawong, C., Phelan, D., O’Sullivan, G. C., Collins, J. K., Bamford, K. B., Lutton, D. A., Collins, J. S. A., O’Loughlin, B., Johnston, B. T., McFarland, R. J., Love, A. H. G., Buchanan, K. D., Fillmore, D., Ardill, J. E. S., Clyne, M., Drumm, B., Cyne, M., Tham, T. C. K., McLaughlin, N., Hughes, D. F., Ferguson, M., Crosbie, J. J., Madden, M., Namnyak, S., O’Connor, F. A., Magbri, Awad El, Stevens, F. M., McCarthy, C. F., Lynch, M., O’Brien, M., Ryan, E., MacMathuna, P., Kelly, P., Lennon, J., Crowe, J., Mulvey, S., Maguire, C., Clarke, E., Cronin, K. J., Kent, P., Mooney, E., Corrigan, T., O’Connell, R., Fitzpatrick, J. M., Gorey, T. F., Prabhaker, M. C., Bannon, C. A., Delaney, C., Duggan, M., Gorey, T., Abuzakouk, M., Lynch, S., Casey, E., Weir, D., Feighery, C., O’Farrelly, C., Fan, X. J., Chua, A., Shahi, C. N., Kelleher, D., Keeling, P. W. N., Parks, R. W., Diamond, T., McCrory, D. C., Johnston, G. W., Clements, W. D. B., Ennis, M., Campbell, G. R., Halliday, M. I., Rowlands, B. J., Wilson, R. H., Williamson, K., McLoughlin, J., Moorehead, R. J., O’Connor, A. M., Johnston, C. F., Gillmore, D., Boreham, C., Caldwell, M. T. P., Jazrawi, S., Byrne, P. J., Walsh, T. N., Hennessy, T. P. J., Li, H., Kay, E. W., Mulcahy, H., Curran, B., O’Donoghue, D., Leader, M., Walsh, C. Barry, O’Sullivan, S. T., Reardon, C. M., Hardiman, C., O’Donnell, J. A., Kirwan, W. O., Brady, M. P., McGreal, G., Hehir, D. J., Brady, M. P., O’Donnell, J., Pender, S. M., Courtney, M. G., Fielding, J. F., Swan, N., Chong, A., Denesh, T. G., Coll, D., McElearney, C., Kay, E., Sant, S., Doyle, J. S., Buckley, M., Cahill, R. J., Beattie, S., Hamilton, H., O’Morain, C., O’Sullivan, K., Forde, A. M., Gilvarry, J., Jackson, J., Alvi, R., Leahy, A., Lynch, G., Lane, B., Browne, H. Y., Keeling, P., Stafford-Johnson, D., Kee, S., Carr, J., Ryan, M. J., Sheehan, S., Broe, P., Deasy, J., O’Donovan, D. A., Bouchier-Hayes, D. M., Kelly, C., Grace, P., Redmond, H. P, Burke, P., Bouchier-Hayes, D. J., O’Malley, K., Qureshi, A., Osborne, H., Monkhouse, W. S., Bouchier-Hayes, D., Goggin, M., Joyce, W. P., Traynor, O., Hyland, J., Beausang, E., Mealy, K., Prendergast, C., Joyce, L., McNicholas, M. M. J., Gibney, R. G., Dolan, J., MacErlean, D. P., Hyland, J. M., Fenlon, H. M., Mulcahy, H. E., Stack, W. A., Skelly, M. M., Hegarty, J. E., Stack, W., O’Donoghue, D. P., Norris, S. M., McNicholas, M., Murray, F. E., Williams, N., Burke, J., Lamort, W., Fitzpatrick, J., Afdhal, N., Gibney, R., McLoughlin, R. F., Mourad, F. H., O’Donnell, L. J. D., Dias, J., Ogutu, E., Farthing, M. J. G., Hoyle, C. H. V., Hill, A. D. K., Darzi, A., Carey, P. D., Menzies-Gow, N., Monson, J. R. T., Goggins, M. G., O’Broin, S., Kelleher, B., Scott, J. M., Weir, D. D., Watson, R. G. P., Goss, B., Angus, P. W., Duckham, N., Sewell, R. B., and Smallwood, R. A.

Published
1993
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4. Irish society of gastroenterology: Proceedings of meeting held in university college, Galway in may 1892

Author

Brannigan, A., Williams, N. N., Grahn, M., Williams, N. S., Fitzpatrick, J. M., O’Connell, P. R., Soong, C. V., Blair, P., Halliday, M. I., Hood, J. M., Rowlands, B. J., D’sa, A. A. B. Barros, Cahill, R. J., Beattie, S., Hamilton, H., O’Morain, C., Kelly, S. J., O’Malley, K. E., Stack, W. A., O’Donoghue, D., Baird, A. W., Cronin, K. J., Kerin, M. J., Crowe, J., MacMathuna, P., Lennon, J., Gorey, T. F., Chua, A., O’Kane, V., Dinan, T. G., Keeling, P. W. N., Mulligan, E., Cronin, K. L., Dervan, P., Ireland, A., Murphy, D., O’Sullivan, G., Ryan, E., Kelly, P., Gilvarry, J., Sant, S., Fan, X. J., Chua, A., Shahi, C. N., O’Connell, M., Weir, D. G., Kelleher, D., McDevitt, J., O’Donoghue, J. M., Horgan, P. G., Byrne, W. J., McGuire, M., Given, H. F., Daw, M. A., Kavanagh, P., O’Mahony, P., Joy, T., Gleeson, F., Mullan, A., Gibney, M., Mannion, Anne, Stevens, F. M., McCarthy, C. F., Killeen, A. A., Murchan, P. M., Reynolds, J. V., Leonard, N., Marks, P., Keane, F. B. V., Tanner, W. A., O’Connell, M. A., Corridan, B., Collins, R., Shannon, R., Cahill, R., Joyce, W. P., Goggin, M., O’Donoghue, D., Hyland, J., Traynor, O., Qureshi, A., DaCosta, M., Brindley, N., Burke, P., Grace, P., Bouchier-Hayes, D., Leahy, A. L., Courtney, G., Osbome, H., O’Donovan, N., O’Donoghue, M., Collins, J. K., Morrissey, D., McCarthy, J. E., Redmond, H. P., Hill, A. D. K., Grace, P. A., Naama, H., Austin, O. M., Bouchier-Hayes, D. M., Daly, J. M., Mulligan, E., Fitzpatrick, J. M., Breslin, D., Delaney, C. P., O’Sullivan, S. T., O’Sullivan, G. C., Kirwan, W. O., Weir, C. D., McGrath, L. T., Maynard, S., Anderson, N. H., Halliday, M. I., D’sa, A. A. B. Barros, Gokulan, C., O’Gorman, T. A., Breshihan, E., Lam, Pin Yin, Skehill, R., Grimes, H., McKeever, J. A., Stokes, M. A., Mehigan, D., Keaveny, T. V., Meehan, J., Molloy, A., Q’Farrelly, C., Scott, J., Dudeney, M. S., Leahy, A., Grace., P. A., McEntee, G., Hcaton, N. D., Douglas, V., Mondragon, R., O’Grady, J., Williams, R., Tan, K. C., Xia, H. X., Keane, C. T., O’Morain, C. A., O’Mahony, A., O’Sullivan, G. C., Corbett, A., O’Mahony, A., Ireland, A., Harte, P., Mulcahy, H., Patchett, S., Stack, W., Gallagher, M., Connolly, K., Doyle, J., Flynn, J. R., Maher, M., Hehir, D., Horgan, A., Stuart, R., Brady, M. P., Johnston, P. W., Johnston, B. T., Collins, B. J., Collins, J. S. A., Love, A. H. G., Marshall, S. G., Parks, T. G., Spence, R. A. J., O’Connor, H. J., Cunnane, K., Duggan, M., MacMalhuna, P., Delaney, C. P., Kerin, M., Gorey, T. F., Attwood, S. E. A., Viani, L., Jeffers, M., Walsh, T. N., Byrne, P. J., Frazer, I., Hennessy, T. P. J., Hill, G. L., Dickey, W., McMillan, S. A., Bharucha, C., Porter, K. G., Rolfe, H., Thornton, J., Attwood, S. E. A., Coleman, J., Stephens, R. B., Hone, S., Holmes, K., Kelly, I. P., Corrigan, T. P., McCrory, D., McCaigue, M., Barclay, G. R., Stack, W. A., Quirke, M., Hegarty, J. E., O’Donoghue, D. P., O’Hanlon, D., and Byrne, J.

Published
1992
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8. Irish society of gastroenterology: Proceedings of the summer meeting held in cork on friday, 3rd and saturday 4th june, 1994

Author

Murphy, K. M., O’Brien, F., Madden, M., Collins, J. K., Lee, G., Fitzgerald, E., Crowley, M., Morgan, J., Shanahan, F., O’Sullivan, G., Khan, M. I., Cherukuri, A. K., Farrell, R. J., Farrell, J., Quinn, P., Noonan, N., Kanduru, C., Keeling, P. W. N., Keely, S. J., Stack, W. A., Skelly, M. M., Stack, M., O’Donoghue, D. P., Baird, A. W., Barry, M. C., Condron, C., Watson, R. W. G., Redmond, H. P., Watson, R. G. K., Bouchier-Hayes, D., McManus, R., Moloney, M., Borton, M., Chuan, Y. T., Finch, A., Weir, D. G., Kelleher, D., Watson, R. G. P., McMillan, S. A., McMaster, D., Evans, A., Merriman, R., MacMathuna, P., Frazier, I., Crowe, J., Lennon, J., Fan, X. G., Fan, X. J., Xia, H., Madrigal, L., Feighery, C., O’Donoghue, D., Whelan, C. A., O’Farrelly, C., Crowley, M. J., O’Leary, P., Devereux, C., White, P., Clarke, E., Norris, S., Crosbie, O., Traynor, O., McEntee, G., Hegarty, J., Marshall, S. G., Spence, R. A. J., Parks, T. G., Barrett, J., O’Brien, M., Sullivan, G. C. O, Walsh, T. N., Mealy, K., Hennessey, T. P. J., Donnelly, V. S., O’Herlihy, C., O’Connell, P. R., Morrissey, D., Lynch, D., Caldwell, M. T. P., Byrne, P. J., Marks, P., Hennessy, T. P. J., Maguire, D., Harvey, B., Wang, J. H., Mahmud, N., McDonald, G. S. A., Windle, H. J., Neary, P., Reid, S., Horgan, P., Hyland, J., Graham, D., Yeoh, P. L., Kelly, P., Gibbons, D., Mulcahy, H., McCarthy, P., Duffy, M. J., Parfrey, N. A., Sheahan, K., Husain, A., O’Suilleabhain, C. B., Waldron, D., Kelly, J., O’Riordain, M., Kirwan, W. O., Parks, R. W., Spencer, E. F. A., Mcllrath, E. M., Johnson, G. W., Carton, J., and Lynch, S.

Published
1994
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9. Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease

Author

Klinische infectiologie en microb. lab., dI&I I&I-4, Ryan, F. J., Ahern, A. M., Fitzgerald, R. S., Laserna-Mendieta, E. J., Power, E. M., Clooney, A. G., O’Donoghue, K. W., McMurdie, P. J., Iwai, S., Crits-Christoph, A., Sheehan, D., Moran, C., Flemer, B., Zomer, A. L., Fanning, A., O’Callaghan, J., Walton, J., Temko, A., Stack, W., Jackson, L., Joyce, S. A., Melgar, S., DeSantis, T. Z., Bell, J. T., Shanahan, F., Claesson, M. J., Klinische infectiologie en microb. lab., dI&I I&I-4, Ryan, F. J., Ahern, A. M., Fitzgerald, R. S., Laserna-Mendieta, E. J., Power, E. M., Clooney, A. G., O’Donoghue, K. W., McMurdie, P. J., Iwai, S., Crits-Christoph, A., Sheehan, D., Moran, C., Flemer, B., Zomer, A. L., Fanning, A., O’Callaghan, J., Walton, J., Temko, A., Stack, W., Jackson, L., Joyce, S. A., Melgar, S., DeSantis, T. Z., Bell, J. T., Shanahan, F., and Claesson, M. J.

Published
2020

10. Irish society of gastroenterology: Proceedings of meeting held 26th & 27th november, 1993 at james connolly memorial hospital, Blanchardstown

Author

Watson, R. W. G., Redmond, H. P., McCarthy, J., Burke, P., Bouchier-Hayes, D., Kelly, C., Watson, R. G. K., Duggan, S., Ahmad, M., Croke, D. T., El-Magbri, A. A., Stevens, F. M., McCarthy, C. F., O’Connor, H., Kanduru, C., Cunnane, K., Marshall, D. G., Chua, A., Keeling, P. W. N., Sullivan, D. J., Coleman, D., Smyth, C. J., Caldwell, M. T. P., Marks, P., Byrne, P. J., Walsh, T. N., Hennessy, T. P. J., Reid, I. M., Hickey, K., Deb, B., O’Callaghan, P., Lawlor, P., Crean, P., Grehan, D., Sweeney, E. C., Kelly, C. J., Rajpal, P., Couse, N. F., Khan, F., Delaney, P. V., Lynch, Sara, Kelleher, D., McManus, R., O’Farrelly, C., Pule, M. A., Lynch, S., Madrigal, L., Hegarty, J., Traynor, O., McEntee, G., Sheahan, K., Carey, E., Stack, W. A., Mulcahy, H., O’Donoghue, D. P., Goggins, M., Mahmud, N., Weir, D. G., Keely, S. J., Baird, A. W., Farrell, R. J., Khan, M. I., Cherukuri, A. K., Noonan, N., Boyle, T. J., Roddie, M. E., Williamson, R. C. N., Habib, N. A., Sharifi, Y., Courtney, M. G., Fielding, J. F., Abuzakouk, M., Feighery, C., Jones, E., O’Briain, S., Casey, E., Prabhakar, M. C., MacMathuna, P., Lennon, J., Crowe, J., Merriman, R., Ryan, E., Kitching, A., Mulligan, E., Kelly, P., Gorey, T. F., Lennon, J. R., McGrath, J. P., Timon, C., Gormally, S. M., Baker, A., MacMahon, P., Tangney, N., Mowet, A., Drumm, B., Kierce, B., Daly, L., Bourke, B., Carroll, R., Durnin, M., Prakash, N., Clyne, M., Cahill, R. J., Kilgallen, C., Beattie, S., Hamilton, H., O’Morain, C. A., Xia, H. X., English, L., Keane, C. T., Fenton, J., Hone, S., Gormley, P., O’Dwyer, T., McShane, D., Leonard, N., Hourihane, D., Whelan, A., Maguire, D., O’Sullivan, G. C., Harvey, B., Farrell, R., Maloney, M., O’Byrne, K., Carey, C., Meagher, P. J., Deasy, J. M., Barrett, J., Collins, J. K., and O’Sullivan, G. C.

Published
1993
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11. Irish society of gastroenterology: Proceedings of meeting held in Craigavon on 28th and 29th May, 1993

Author

Gardiner, K. R., Barclay, G. R., McCaigue, M. D., Erwin, P. J., Halliday, M. I., Maxwell, R. J., Rowlands, B. J., Whiteside, M. C. R., Anderson, N., Wilson, R. H., Kee, F., Moorehead, R. J., H Russell, S. E., Clements, B., Hamilton, P., Cameron, S., Evoy, D. A., Regan, M., Attwood, S. E. A., Keeling, P. W. N., Stephens, R. B., Caldwell, M. T. P., Marks, P., Byrne, P. J., Walsh, T. N., Hennessy, T. P. J., O’Broin, E., Donohoe, J., Mealy, K., Kerin, M., Gillen, P., Tanner, W. A., Keane, F. B. V., O’Malley, K., Neligan, M., McEntee, G., Bouchier Hayes, D., Morrin, M., Kelly, M., Khan, F., Barrett, N., Williams, N., Delaney, P., Goggins, M. G., Mahmud, N., Hall, N., O’Connell, M., Weir, D. G., Kelleher, D., Thornton, G., O’Sullivan, M., O’Sullivan, G., Collins, J. K., Cahill, R. J., Beattie, S., Hamilton, H., O’Morain, C. A., Chua, A., Dinan, T. G., Noonan, N., Rovati, L. C., Keating, J., Somasundaram, S., Smithson, J., Menzies, I., Francis, N., Bjarnason, I., Gazzard, B. G., O’Donovan, D., Kelly, C., Bouchier-Hayes, D. M., Watson, W., Redmond, P., Burke, P., Bouchier-Hayes, D. J., O’Mahony, A. M., Erwin, P., McCaigue, M., Halliday, I., Rowlands, B., Golden, B., Loughnane, F., Brindley, N., Dudley, S., Drebin, J., Geraghty, J., Broe, P., Stinson, J., Feely, J., Fan, X. J., Fan, X. G., Caldwell, T. P., Evoy, D., Lawlor, P., Attwood, S. E., Gilvarry, J., O’Morain, C., Stafford Johnson, D. B., Keeling, F., Kent, P., Hennebry, T., Burke, J., Mooney, E., McMathuna, P., Crowe, J., Fitzpatrick, J. M., Gorey, T. F., Malone, F., Reynolds, J., Walsh, B., Ellias, Y., Traynor, O., Couse, N., Burke, G., Fallon, C., Kidney, D., Murray, E., Buckley, M., McCarthy, M., O’Donovan, N., Stack, W. A., Keely, S., O’Donoghue, D. P., Baird, A. W., Duggan, A., O’Brien, F., Abuzakouk, M., Feighery, C., Bergin, C., Casey, E., Weir, D., O’Farrelly, C., Mulcahy, H., Jeffers, M., O’Dowd, G., Stagg, M., Toner, M., Fenlon, H., Ashbury, K., O’ Brien, M., Ireland, A., and Morain, C. O.

Published
1993
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13. Constitutional law - preemption and equal protection.

Author

Stack, W. Brian

Subjects
Exclusive and concurrent legislative powers -- Cases, Municipal home rule -- Cases, Tobacco industry -- Cases, C.I.C. Corp. v. Township of East Brunswick 628 A.2d 753 (N.J. Super. Ct. App. Div. 1993)
Published
1994

25. From The Cover: Increased salinization of fresh water in the northeastern United States

Author

Kaushal, S. S., Stack, W. P., Fisher, G. T., Likens, G. E., Kelly, V. R., Belt, K. T., Band, L. E., and Groffman, P. M.

Abstract

Chloride concentrations are increasing at a rate that threatens the availability of fresh water in the northeastern United States. Increases in roadways and deicer use are now salinizing fresh waters, degrading habitat for aquatic organisms, and impacting large supplies of drinking water for humans throughout the region. We observed chloride concentrations of up to 25% of the concentration of seawater in streams of Maryland, New York, and New Hampshire during winters, and chloride concentrations remaining up to 100 times greater than unimpacted forest streams during summers. Mean annual chloride concentration increased as a function of impervious surface and exceeded tolerance for freshwater life in suburban and urban watersheds. Our analysis shows that if salinity were to continue to increase at its present rate due to changes in impervious surface coverage and current management practices, many surface waters in the northeastern United States would not be potable for human consumption and would become toxic to freshwater life within the next century.

Published
2005
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28. BOOK REVIEW

Author

STACK, W. and HAWKEY, C.

Subjects
Book Review
Published
1997

42. Cytomegalovirus myocarditis following liver transplantation.

Author

Stack, W. A., Mulcahy, H. E., Fenelon, L., and Hegarty, J. E.

Subjects
CYTOMEGALOVIRUS disease diagnosis, DNA analysis, CYTOMEGALOVIRUS diseases, CYTOMEGALOVIRUSES, ECHOCARDIOGRAPHY, ELECTROCARDIOGRAPHY, LIVER transplantation, CARDIOMYOPATHIES, OPPORTUNISTIC infections, POLYMERASE chain reaction, SURGICAL complications
Abstract

Cytomegalovirus (CMV) infections are commonly found in patients on immunosuppressive therapy following liver transplantation. However, acute myocarditis is an extremely rare manifestation of CMV infection in this setting. We report the case of a patient who developed acute myocarditis with severe biventricular failure with a cardiac ejection fraction of less than 10%, 6 weeks following orthotopic liver transplantation. Systemic CMV infection was diagnosed on the basis of a clinical viraemia, the presence of CMV antigen in urine, blood, and throat swab, and an associated four-fold rise in serum antibody titres to CMV. A full recovery ensued following treatment with standard anti-cardiac failure therapy and a 10 day course of intravenous ganciclovir. [ABSTRACT FROM PUBLISHER]

Published
1994

47. Chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease.

Author

Hawkey, Christopher J., Stack, William A., Hawkey, C J, and Stack, W A

Subjects
*LETTERS to the editor, *CROHN'S disease
Abstract

A letter to the editor is presented in response to the article "A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor 1 for Crohn's disease," by S.R. Targan, S.B. Hanauer and colleagues in the October 9, 1998 issue.

Published
1998
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48. An Investigation Into What Factors Influence Patterns of Clinical Presentation in Adult-Onset Celiac Disease.

Author

O'Shaughnessy K, Stack W, Hayes T, Kenny E, and Jackson L

Abstract

Introduction Anxiety and depression are common in patients with celiac disease (CD), and many psychosocial explanations have been considered. However, as the gut-brain axis is becoming increasingly understood, biological mechanisms have been proposed, including vitamin or mineral deficiencies and gut inflammation. Aim To investigate associations between anxiety/depression and symptom severity, vitamin status, and gut inflammation in untreated adult patients presenting with a serologic indication of celiac disease. Methods The Hospital Anxiety and Depression Scale (HADS), Celiac Symptom Index (CSI), and Perceived Stress Scale (PSS) questionnaires were administered to 17 patients over a 14-month period. Duodenal biopsies were obtained to determine histological Marsh scores. Iron, B12, folate, vitamin D, and thyroid function tests were reviewed. Results HADS-Anxiety (HADS-A) scores correlated with symptom severity (rs = 0.62, P = 0.008), but not with any hematological investigations or degree of intestinal inflammation. No patients scored highly for depression. Iron deficiency was the most common deficiency observed (n = 6). Greater symptomatology was associated with female sex (females versus males: average CSI scores, 32.1 versus 23.6; t17 = 2.1, P < 0.05), younger age at presentation (rs = -0.55, P = 0.02), and lower Marsh score (Marsh 0 versus Marsh 3C: mean scores, 36 versus 24.5; t5 = 6.2, P = 0.009). Conclusions The anxiety experienced by patients with CD at presentation is likely a reactive form due to gastrointestinal symptoms rather than a biological process specific to CD. Older patients tend to present less symptomatically, highlighting the need for screening of at-risk individuals. The degree of villous atrophy does not correlate well with clinical presentation. Highly symptomatic patients should be screened for anxiety at presentation., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2022, O'Shaughnessy et al.)

Published
2022
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49. Nocardia asteroides lung abscess in acute ulcerative colitis treated with cyclosporine.

Author

Stack WA, Richardson PD, Logan RP, Mahida YR, and Hawkey CJ

Subjects
Acute Disease, Aged, Colitis, Ulcerative drug therapy, Humans, Lung Abscess complications, Lung Abscess diagnostic imaging, Male, Nocardia Infections complications, Nocardia Infections diagnostic imaging, Opportunistic Infections complications, Opportunistic Infections diagnostic imaging, Radiography, Colitis, Ulcerative complications, Cyclosporine therapeutic use, Immunosuppressive Agents therapeutic use, Lung Abscess diagnosis, Nocardia Infections diagnosis, Nocardia asteroides, Opportunistic Infections diagnosis
Abstract

Cyclosporine is a potent suppresser of cell-mediated immunity that is mainly used in organ transplantation to prevent rejection. It is also being used increasingly outside of transplantation and probably is the only new treatment to have made an impact in acute ulcerative colitis (UC) resistant to steroid therapy. We describe a case of Nocardia asteroides lung abscess in a patient treated with cyclosporine for acute steroid resistant UC that was successfully managed with antibiotics and by discontinuing cyclosporine. With increasing use of cyclosporine for acute UC it is to be anticipated that opportunistic infections such as Nocardia will be more frequently encountered in the future.

Published
2001
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50. Current pharmacotherapy for inflammatory bowel disease.

Author

McKaig BC and Stack WA

Subjects
Clinical Trials as Topic, Colitis, Ulcerative drug therapy, Crohn Disease drug therapy, Humans, Gastrointestinal Agents therapeutic use, Inflammatory Bowel Diseases drug therapy
Abstract

Ulcerative colitis (UC) and Crohn's disease (CD), collectively termed inflammatory bowel disease (IBD), are chronic spontaneously relapsing enteropathies of unknown aetiology. Pharmacotherapy for IBD has essentially been unchanged for over twenty years, with therapy based around 5-aminosalicylic acid (5-ASA) preparations, corticosteroids, antibiotics and immunosuppression. Much of the controversy surrounding optimal use of these drugs in IBD arises as a consequence of methodological deficiencies in many of the early trials combined with the difficulty in consistent patient selection due to the heterogeneous nature of both UC and CD. More recently, well-designed clinical trials have attempted to provide an 'evidence based' approach to managing IBD which, in time, will allow optimisation of current therapies and accurate evaluation of novel agents. Over the past two decades, improved research methodology has considerably increased our molecular understanding of the aetiopathogenesis of IBD which has ultimately lead to the development of specific mediator directed or 'designer' drug therapy for IBD. This review evaluates the literature on current IBD therapy, summarises the important recent studies which have made an impact on clinical practice, and examines the risks and benefits of the novel agents which are currently under investigation in clinical trials of IBD therapy.

Published
1999
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