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The last British-Irish Ice Sheet (BIIS) created a landscape with many sedimentary basins that preserve archives of paleoenvironmental and paleoclimatic change during the Last Glacial-Interglacial Transition (LGIT; ~ 18-8 ka BP). The typical lithostratigraphic succession of these archives is composed of minerogenic/allogenic sediments formed during cold climatic conditions and organic-rich/authigenic sediments during warmer climates. This paper presents a multi-core lithostratigraphy compiled from the extant lake and surrounding basin at Llangorse Lake, south Wales, a basin lying within the southernmost limits of the last BIIS. This lake contains one of the longest continuous terrestrial sediment successions in the UK. Uncertainty previously existed concerning the presence and distribution of sediments at the site related to the Windermere Interstadial (~ 14.7 to ~ 12.9 ka BP) and Loch Lomond Stadial (~ 12.9 to 11.7 ka BP). A new borehole survey demonstrates that LGIT-age sediments are present at the site with nekron mud (gyttja), corresponding to the Lateglacial Interstadial, deposited in the deeper part of the lake waters and that these deposits are equivalent in age to marl deposits found at shallower depths at the margins of the basin. These deposits are associated with warmer conditions experienced during the Windermere Interstadial and Holocene, whilst minerogenic-rich sediments were deposited during the colder climatic conditions of the Dimlington Stadial and the Loch Lomond Stadial with rangefinder radiocarbon dates confirming this attribution. A model of lake level changes shows that drainage of the Dimlington Stadial glacial lake caused the largest fall, but there was also a further, smaller lake level fall at the end of the Windermere Interstadial and/or the start of the Loch Lomond Stadial, before the level rose in the early Holocene. The lithostratigraphic results presented here form the framework for further paleoenvironmental and paleoclimatic research at Llangorse Lake.

Volcanoes in the East Asian/Pacific region have been the source of some of the largest magnitude eruptions during the Quaternary, and accurately evaluating their eruptive histories is essential for hazard assessments. To overcome difficulties in resolving and precisely dating eruptions in the near‐source realm, the high‐resolution (varved) sediments of Lake Suigetsu (central Honshu, Japan) were examined for the presence of non‐visible (cryptotephra) layers from 50 ka up until the 30 ka AT caldera‐forming event of Aira volcano. Cryptotephra layers are four times more frequently preserved than visible markers in the Suigetsu sediments, meaning that this archive provides a unique and unprecedented record of eruptions that were dispersed towards the densely populated regions of central Honshu. Major and trace element volcanic glass chemistry is used to fingerprint the ash layers and pinpoint their volcanic origin. Tephras are found throughout the investigated sediments, but the highest abundance of ash fall events are recorded between 39 and 30 ka, capturing a period of intense volcanism at calderas on Kyushu Island (Japan). The augmented Suigetsu tephrostratigraphy records at least seven eruption events from Aso caldera (southern Kyushu) that post‐date the widespread ACP‐4 Plinian eruption (ca. 50 ka), and four explosive events from Aira (central Kyushu) that occurred leading up to the catastrophic caldera‐forming AT eruption (ca. 30 ka).

Accurately evaluating the tempo and magnitude of pre-historic eruptions is essential for hazard assessments. Here we demonstrate the importance of integrating records from locations close to the volcano with those in distal regions to generate more comprehensive event stratigraphies. The annually laminated (varved) and intensely radiocarbon dated lacustrine sediments of Lake Suigetsu (SG06 core), Japan are used to place chronological constraints on the tempo of volcanism at two stratovolcanoes located favourably upwind of the lake along the South-West Japan Arc, Sambe and Daisen. Major and trace element glass compositions are used to assign visible ash (tephra) layers preserved in the SG06 sediment core to past explosive eruptions from these volcanoes. Integrating these stratigraphies confirm that the ~150 ka long lake sequence records nine visible ash layers from Daisen and five from Sambe. The SG06 record captures two periods of closely spaced eruptions at Daisen volcano. The first period begins at ~61.1 ka with three explosive eruptions over ~10 ka, with two events separated by as little as 1.5 ka. One layer (SG06–4281), dated at 59.6 ± 5.5 ka (95.4% probability), relates to the large magnitude, and widely dispersed Daisen Kurayoshi Pumice (DKP) eruption. The other period of frequent activity began at 29,837 ± 96 IntCal13 yrs. BP (95.4% probability) with five widely dispersed ash fall events associated with explosive eruptions separated by approximately 6, 936, 5 and 438 years. The integrated proximal-distal event stratigraphy and the high-precision SG06 chronology provide unique insights into the timing and frequency of past explosive volcanism from Daisen and Sambe, which has implications for the prediction of future eruption scenarios.

The Neogene and Quaternary are characterized by enormous changes in global climate and environments, including global cooling and the establishment of northern high-latitude glaciers. These changes reshaped global ecosystems, including the emergence of tropical dry forests and savannahs that are found in Africa today, which in turn may have influenced the evolution of humans and their ancestors. However, despite decades of research we lack long, continuous, well-resolved records of tropical climate, ecosystem changes, and surface processes necessary to understand their interactions and influences on evolutionary processes. Lake Tanganyika, Africa, contains the most continuous, long continental climate record from the mid-Miocene (∼ 10 Ma) to the present anywhere in the tropics and has long been recognized as a top-priority site for scientific drilling. The lake is surrounded by the Miombo woodlands, part of the largest dry tropical biome on Earth. Lake Tanganyika also harbors incredibly diverse endemic biota and an entirely unexplored deep microbial biosphere, and it provides textbook examples of rift segmentation, fault behavior, and associated surface processes. To evaluate the interdisciplinary scientific opportunities that an ICDP drilling program at Lake Tanganyika could offer, more than 70 scientists representing 12 countries and a variety of scientific disciplines met in Dar es Salaam, Tanzania, in June 2019. The team developed key research objectives in basin evolution, source-to-sink sedimentology, organismal evolution, geomicrobiology, paleoclimatology, paleolimnology, terrestrial paleoecology, paleoanthropology, and geochronology to be addressed through scientific drilling on Lake Tanganyika. They also identified drilling targets and strategies, logistical challenges, and education and capacity building programs to be carried out through the project. Participants concluded that a drilling program at Lake Tanganyika would produce the first continuous Miocene-present record from the tropics, transforming our understanding of global environmental change, the environmental context of human origins in Africa, and providing a detailed window into the dynamics, tempo and mode of biological diversification and adaptive radiations., SCOPUS: ar.j, info:eu-repo/semantics/published

The B-Tm tephra, dispersed during the highly explosive Changbaishan ‘Millennium’ eruption (ca. 940–950 CE) and a key marker layer within the Greenland ice cores, has now been identified in the Lake Suigetsu (SG06) sedimentary sequence, central Japan. The major element geochemistry of the volcanic glasses within this tephra layer are compared to a new glass dataset from the distal type-locality (Tomakomai Port, Hokkaido) and other published ‘Millennium’ eruption/B-Tm deposits, to verify this correlation. The discovery of the B-Tm tephra in the Lake Suigetsu record provides, to date, the most southerly identification of this ash and, crucially, the first direct tie-point between this high-resolution, mid-latitude palaeoclimate archive and the Greenland ice cores. These findings present significant encouragement for on-going research into the tephrostratigraphy of East Asia, focusing on the identification of widely-dispersed tephra layers which can facilitate the synchronisation of disparate palaeoclimate archives and thus enable the assessment of spatio-temporal variations in past climatic change.

The Greenland Stadial 1 (GS-1; ~12.9 to 11.65 kyr cal BP) was a period of North Atlantic cooling, thought to have been initiated by North America fresh water runoff that caused a sustained reduction of North Atlantic Meridional Overturning Circulation (AMOC), resulting in an antiphase temperature response between the hemispheres (the 'bipolar seesaw'). Here we exploit sub-fossil New Zealand kauri trees to report the first securely dated, decadally-resolved atmospheric radiocarbon ((14)C) record spanning GS-1. By precisely aligning Southern and Northern Hemisphere tree-ring (14)C records with marine (14)C sequences we document two relatively short periods of AMOC collapse during the stadial, at ~12,920-12,640 cal BP and 12,050-11,900 cal BP. In addition, our data show that the interhemispheric atmospheric (14)C offset was close to zero prior to GS-1, before reaching 'near-modern' values at ~12,660 cal BP, consistent with synchronous recovery of overturning in both hemispheres and increased Southern Ocean ventilation. Hence, sustained North Atlantic cooling across GS-1 was not driven by a prolonged AMOC reduction but probably due to an equatorward migration of the Polar Front, reducing the advection of southwesterly air masses to high latitudes. Our findings suggest opposing hemispheric temperature trends were driven by atmospheric teleconnections, rather than AMOC changes.

This is the 35th list of AMS radiocarbon determinations measured at the Oxford Radiocarbon Accelerator Unit (ORAU). Amongst some of the sites included here are the latest series of determinations from the key sites of Abydos, El Mirón, Ban Chiang, Grotte de Pigeons (Taforalt), Alepotrypa and Oberkassel, as well as others dating to the Palaeolithic, Mesolithic and later periods. Comments on the significance of the results are provided by the submitters of the material.

This paper introduces the aims and scope of the RESET project (. RESponse of humans to abrupt Environmental Transitions), a programme of research funded by the Natural Environment Research Council (UK) between 2008 and 2013; it also provides the context and rationale for papers included in a special volume of Quaternary Science Reviews that report some of the project's findings. RESET examined the chronological and correlation methods employed to establish causal links between the timing of abrupt environmental transitions (AETs) on the one hand, and of human dispersal and development on the other, with a focus on the Middle and Upper Palaeolithic periods. The period of interest is the Last Glacial cycle and the early Holocene (c. 100-8 ka), during which time a number of pronounced AETs occurred. A long-running topic of debate is the degree to which human history in Europe and the Mediterranean region during the Palaeolithic was shaped by these AETs, but this has proved difficult to assess because of poor dating control. In an attempt to move the science forward, RESET examined the potential that tephra isochrons, and in particular non-visible ash layers (cryptotephras), might offer for synchronising palaeo-records with a greater degree of finesse. New tephrostratigraphical data generated by the project augment previously-established tephra frameworks for the region, and underpin a more evolved tephra 'lattice' that links palaeo-records between Greenland, the European mainland, sub-marine sequences in the Mediterranean and North Africa. The paper also outlines the significance of other contributions to this special volume: collectively, these illustrate how the lattice was constructed, how it links with cognate tephra research in Europe and elsewhere, and how the evidence of tephra isochrons is beginning to challenge long-held views about the impacts of environmental change on humans during the Palaeolithic. © 2015 Elsevier Ltd., RESET was funded through Consortium Grants awarded by the Natural Environment Research Council, UK, to a collaborating team drawn from four institutions: Royal Holloway University of London (grant reference NE/E015905/1), the Natural History Museum, London (NE/E015913/1), Oxford University (NE/E015670/1) and the University of Southampton, including the National Oceanography Centre (NE/01531X/1). The authors also wish to record their deep gratitude to four members of the scientific community who formed a consultative advisory panel during the lifetime of the RESET project: Professor Barbara Wohlfarth (Stockholm University), Professor Jørgen Peder Steffensen (Niels Bohr Institute, Copenhagen), Dr. Martin Street (Romisch-Germanisches Zentralmuseum, Neuwied) and Professor Clive Oppenheimer (Cambridge University). They provided excellent advice at key stages of the work, which we greatly valued. We also thank Jenny Kynaston (Geography Department, Royal Holloway) for construction of several of the figures in this paper, and Debbie Barrett (Elsevier) and Colin Murray Wallace (Editor-in-Chief, QSR) for their considerable assistance in the production of this special volume.

BACKGROUND: Diabetic retinopathy (DR) is an important biomarker for microvascular disease and blindness. Digital fundus photography is a cost-effective way of screening for DR. Access to DR screening is difficult for many South Africans with diabetes. OBJECTIVE: To perform external quality assurance (EQA) on graders registered in the Ophthalmological Society of South Africa DR screening programme. METHODS: Graders registered on the South African (SA) Diabetic Register website were invited to participate in the study. The Scottish EQA software system was used to enable on-line grading of 100 retinal photographs. Expert National Health Service graders provided the consensus expert grading for the image set. RESULTS: Two hundred and sixty-one participants completed the EQA process, including nine ophthalmologists, 243 optometrists, and nine other graders. A wide range of outcomes were demonstrated, with a mean sensitivity of 0.905 (range 0.286 - 1.000) and mean specificity of 0.507 (0.000 - 0.935). The mean diagnostic odds ratio was calculated to be 12.3 (range 0.147 - 148.2). CONCLUSIONS: This is the first quality assurance study conducted with SA healthcare professionals. The outcomes are of interest to all stakeholders dealing with the diabetes epidemic. The disparity in grader performance indicates room for improvement. The results demonstrate a high referral rate to ophthalmology, suggesting that on average graders are performing safely, but with a high number of inappropriate referrals.

Calibration is a core element of radiocarbon dating and is undergoing rapid development on a number of different fronts. This is most obvious in the area of 14C archives suitable for calibration purposes, which are now demonstrating much greater coherence over the earlier age range of the technique. Of particular significance to this end is the development of purely terrestrial archives such as those from the Lake Suigetsu sedimentary profile and Kauri tree rings from New Zealand, in addition to the groundwater records from speleothems. Equally important, however, is the development of statistical tools that can be used with, and help develop, such calibration data. In the context of sedimentary deposition, age-depth modeling provides a very useful way to analyze series of measurements from cores, with or without the presence of additional varve information. New methods are under development, making use of model averaging, that generate more robust age models. In addition, all calibration requires a coherent approach to outliers, for both single samples and where entire data sets might be offset relative to the calibration curve. This paper looks at current developments in these areas.

Publication in the conference proceedings of EUSIPCO, Antalya, Turkey, 2005