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2. Using ENGAGED for CHANGE to Develop a Multicultural Intervention to Reduce Disparities among Sexual and Gender Minorities in Appalachia.

Author

Rhodes, Scott D., Tanner, Amanda E., Alonzo, Jorge, Mann-Jackson, Lilli, Chaffin, John W., Garcia, Manuel, Erb, Hannah J., Sucaldito, Ana D., Faller, Rachel E. Williams, Stafford, Jeanette M., Russell, Laurie, Weil, Peggy H., Jibriel, Mohammed Sheikh Eldin, McGuire, Tucker, Wilkin, Aimee M., Aguilar-Palma, Sandy K., and Kline, David M.

Subjects
SEXUALLY transmitted diseases, SEXUAL minorities, TRANSGENDER people, NONBINARY people, VIRUS diseases, PRE-exposure prophylaxis
Abstract

Background: Gay, bisexual, queer, and other men who have sex with men (GBQMSM) and transgender persons in Appalachia are at an increased risk for HIV, sexually transmitted infections (STIs), hepatitis C virus (HCV), mpox (formerly known as monkeypox) and are less likely to use prevention and care services. Objectives: Our community-based participatory research partnership sought to develop an intervention to increase use of HIV, STI, HCV, and mpox prevention and care services among diverse GBQMSM and transgender and nonbinary persons living in rural Appalachia. Methods: We used ENGAGED for CHANGE , a novel community-engaged participatory intervention development process, to integrate two evidence-based strategies—community-based peer navigation and mHealth—into a multi-cultural intervention. Results: The developed Appalachian Access Project intervention contains five modules to train GBQMSM and transgender and nonbinary persons to serve as peer navigators (known as "community health leaders") within their social networks. The modules are designed to increase awareness of HIV, STIs, HCV, and mpox and their prevention and care; provide guidance on how to promote use of services, including pre-exposure prophylaxis, syringe services, and medically supervised gender-affirming hormone therapy; improve understanding of social determinants of health; and increase ability to effectively communicate and apply social support strategies in person and through mHealth social media. Conclusions: The Appalachian Access Project intervention builds on the strong, preexisting social networks of GBQMSM and transgender and nonbinary persons. It is designed to meet the needs and priorities of underserved and minoritized communities in rural Appalachia through community-based peer navigation and mHealth. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

Author

Postmus, Iris, Warren, Helen R, Trompet, Stella, Arsenault, Benoit J, Avery, Christy L, Bis, Joshua C, Chasman, Daniel I, de Keyser, Catherine E, Deshmukh, Harshal A, Evans, Daniel S, Feng, QiPing, Li, Xiaohui, Smit, Roelof AJ, Smith, Albert V, Sun, Fangui, Taylor, Kent D, Arnold, Alice M, Barnes, Michael R, Barratt, Bryan J, Betteridge, John, Boekholdt, S Matthijs, Boerwinkle, Eric, Buckley, Brendan M, Chen, Y-D Ida, de Craen, Anton JM, Cummings, Steven R, Denny, Joshua C, Dubé, Marie Pierre, Durrington, Paul N, Eiriksdottir, Gudny, Ford, Ian, Guo, Xiuqing, Harris, Tamara B, Heckbert, Susan R, Hofman, Albert, Hovingh, G Kees, Kastelein, John JP, Launer, Leonore J, Liu, Ching-Ti, Liu, Yongmei, Lumley, Thomas, McKeigue, Paul M, Munroe, Patricia B, Neil, Andrew, Nickerson, Deborah A, Nyberg, Fredrik, O'Brien, Eoin, O'Donnell, Christopher J, Post, Wendy, Poulter, Neil, Vasan, Ramachandran S, Rice, Kenneth, Rich, Stephen S, Rivadeneira, Fernando, Sattar, Naveed, Sever, Peter, Shaw-Hawkins, Sue, Shields, Denis C, Slagboom, P Eline, Smith, Nicholas L, Smith, Joshua D, Sotoodehnia, Nona, Stanton, Alice, Stott, David J, Stricker, Bruno H, Stürmer, Til, Uitterlinden, André G, Wei, Wei-Qi, Westendorp, Rudi GJ, Whitsel, Eric A, Wiggins, Kerri L, Wilke, Russell A, Ballantyne, Christie M, Colhoun, Helen M, Cupples, L Adrienne, Franco, Oscar H, Gudnason, Vilmundur, Hitman, Graham, Palmer, Colin NA, Psaty, Bruce M, Ridker, Paul M, Stafford, Jeanette M, Stein, Charles M, Tardif, Jean-Claude, Caulfield, Mark J, Jukema, J Wouter, Rotter, Jerome I, and Krauss, Ronald M

Subjects
Pharmacology and Pharmaceutical Sciences, Biological Sciences, Biomedical and Clinical Sciences, Genetics, Atherosclerosis, Human Genome, Cardiovascular, Stroke, Good Health and Well Being, Cholesterol Ester Transfer Proteins, Cholesterol, HDL, Female, Genome-Wide Association Study, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, Pharmacogenomic Variants, Polymorphism, Single Nucleotide, Treatment Outcome, White People, Genome-wide association study, HDL-cholesterol, Statins, pharmacogenetics, Medical and Health Sciences, Genetics & Heredity, Clinical sciences
Abstract

BackgroundIn addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Inter-individual variation in HDL-C response to statins may be partially explained by genetic variation.Methods and resultsWe performed a meta-analysis of genome-wide association studies (GWAS) to identify variants with an effect on statin-induced high density lipoprotein cholesterol (HDL-C) changes. The 123 most promising signals with p

Published
2016

4. Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

Author

Liu, Chunyu, Kraja, Aldi T, Smith, Jennifer A, Brody, Jennifer A, Franceschini, Nora, Bis, Joshua C, Rice, Kenneth, Morrison, Alanna C, Lu, Yingchang, Weiss, Stefan, Guo, Xiuqing, Palmas, Walter, Martin, Lisa W, Chen, Yii-Der Ida, Surendran, Praveen, Drenos, Fotios, Cook, James P, Auer, Paul L, Chu, Audrey Y, Giri, Ayush, Zhao, Wei, Jakobsdottir, Johanna, Lin, Li-An, Stafford, Jeanette M, Amin, Najaf, Mei, Hao, Yao, Jie, Voorman, Arend, Larson, Martin G, Grove, Megan L, Smith, Albert V, Hwang, Shih-Jen, Chen, Han, Huan, Tianxiao, Kosova, Gulum, Stitziel, Nathan O, Kathiresan, Sekar, Samani, Nilesh, Schunkert, Heribert, Deloukas, Panos, Li, Man, Fuchsberger, Christian, Pattaro, Cristian, Gorski, Mathias, Kooperberg, Charles, Papanicolaou, George J, Rossouw, Jacques E, Faul, Jessica D, Kardia, Sharon LR, Bouchard, Claude, Raffel, Leslie J, Uitterlinden, André G, Franco, Oscar H, Vasan, Ramachandran S, O'Donnell, Christopher J, Taylor, Kent D, Liu, Kiang, Bottinger, Erwin P, Gottesman, Omri, Daw, E Warwick, Giulianini, Franco, Ganesh, Santhi, Salfati, Elias, Harris, Tamara B, Launer, Lenore J, Dörr, Marcus, Felix, Stephan B, Rettig, Rainer, Völzke, Henry, Kim, Eric, Lee, Wen-Jane, Lee, I-Te, Sheu, Wayne H-H, Tsosie, Krystal S, Edwards, Digna R Velez, Liu, Yongmei, Correa, Adolfo, Weir, David R, Völker, Uwe, Ridker, Paul M, Boerwinkle, Eric, Gudnason, Vilmundur, Reiner, Alexander P, van Duijn, Cornelia M, Borecki, Ingrid B, Edwards, Todd L, Chakravarti, Aravinda, Rotter, Jerome I, Psaty, Bruce M, Loos, Ruth JF, Fornage, Myriam, Ehret, Georg B, Newton-Cheh, Christopher, Levy, Daniel, and Chasman, Daniel I

Subjects
Biological Sciences, Genetics, Prevention, Hypertension, Cardiovascular, 2.1 Biological and endogenous factors, Blood Pressure, Exome, Genetic Variation, Genome, Human, Genome-Wide Association Study, Genotype, Humans, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, CHD Exome+ Consortium, ExomeBP Consortium, GoT2DGenes Consortium, T2D-GENES Consortium, Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia, CKDGen Consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Meta-analyses of association results for blood pressure using exome-centric single-variant and gene-based tests identified 31 new loci in a discovery stage among 146,562 individuals, with follow-up and meta-analysis in 180,726 additional individuals (total n = 327,288). These blood pressure-associated loci are enriched for known variants for cardiometabolic traits. Associations were also observed for the aggregation of rare and low-frequency missense variants in three genes, NPR1, DBH, and PTPMT1. In addition, blood pressure associations at 39 previously reported loci were confirmed. The identified variants implicate biological pathways related to cardiometabolic traits, vascular function, and development. Several new variants are inferred to have roles in transcription or as hubs in protein-protein interaction networks. Genetic risk scores constructed from the identified variants were strongly associated with coronary disease and myocardial infarction. This large collection of blood pressure-associated loci suggests new therapeutic strategies for hypertension, emphasizing a link with cardiometabolic risk.

Published
2016

5. Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Author

Lagou, Vasiliki, Mägi, Reedik, Hottenga, Jouke- Jan, Grallert, Harald, Perry, John R. B., Bouatia-Naji, Nabila, Marullo, Letizia, Rybin, Denis, Jansen, Rick, Min, Josine L., Dimas, Antigone S., Ulrich, Anna, Zudina, Liudmila, Gådin, Jesper R., Jiang, Longda, Faggian, Alessia, Bonnefond, Amélie, Fadista, Joao, Stathopoulou, Maria G., Isaacs, Aaron, Willems, Sara M., Navarro, Pau, Tanaka, Toshiko, Jackson, Anne U., Montasser, May E., O’Connell, Jeff R., Bielak, Lawrence F., Webster, Rebecca J., Saxena, Richa, Stafford, Jeanette M., Pourcain, Beate St, Timpson, Nicholas J., Salo, Perttu, Shin, So-Youn, Amin, Najaf, Smith, Albert V., Li, Guo, Verweij, Niek, Goel, Anuj, Ford, Ian, Johnson, Paul C. D., Johnson, Toby, Kapur, Karen, Thorleifsson, Gudmar, Strawbridge, Rona J., Rasmussen-Torvik, Laura J., Esko, Tõnu, Mihailov, Evelin, Fall, Tove, Fraser, Ross M., Mahajan, Anubha, Kanoni, Stavroula, Giedraitis, Vilmantas, Kleber, Marcus E., Silbernagel, Günther, Meyer, Julia, Müller-Nurasyid, Martina, Ganna, Andrea, Sarin, Antti-Pekka, Yengo, Loic, Shungin, Dmitry, Luan, Jian’an, Horikoshi, Momoko, An, Ping, Sanna, Serena, Boettcher, Yvonne, Rayner, N. William, Nolte, Ilja M., Zemunik, Tatijana, Iperen, Erik van, Kovacs, Peter, Hastie, Nicholas D., Wild, Sarah H., McLachlan, Stela, Campbell, Susan, Polasek, Ozren, Carlson, Olga, Egan, Josephine, Kiess, Wieland, Willemsen, Gonneke, Kuusisto, Johanna, Laakso, Markku, Dimitriou, Maria, Hicks, Andrew A., Rauramaa, Rainer, Bandinelli, Stefania, Thorand, Barbara, Liu, Yongmei, Miljkovic, Iva, Lind, Lars, Doney, Alex, Perola, Markus, Hingorani, Aroon, Kivimaki, Mika, Kumari, Meena, Bennett, Amanda J., Groves, Christopher J., Herder, Christian, Koistinen, Heikki A., Kinnunen, Leena, Faire, Ulf de, Bakker, Stephan J. L., Uusitupa, Matti, Palmer, Colin N. A., Jukema, J. Wouter, Sattar, Naveed, Pouta, Anneli, Snieder, Harold, Boerwinkle, Eric, Pankow, James S., Magnusson, Patrik K., Krus, Ulrika, Scapoli, Chiara, de Geus, Eco J. C. N., Blüher, Matthias, Wolffenbuttel, Bruce H. R., Province, Michael A., Abecasis, Goncalo R., Meigs, James B., Hovingh, G. Kees, Lindström, Jaana, Wilson, James F., Wright, Alan F., Dedoussis, George V., Bornstein, Stefan R., Schwarz, Peter E. H., Tönjes, Anke, Winkelmann, Bernhard R., Boehm, Bernhard O., März, Winfried, Metspalu, Andres, Price, Jackie F., Deloukas, Panos, Körner, Antje, Lakka, Timo A., Keinanen-Kiukaanniemi, Sirkka M., Saaristo, Timo E., Bergman, Richard N., Tuomilehto, Jaakko, Wareham, Nicholas J., Langenberg, Claudia, Männistö, Satu, Franks, Paul W., Hayward, Caroline, Vitart, Veronique, Kaprio, Jaakko, Visvikis-Siest, Sophie, Balkau, Beverley, Altshuler, David, Rudan, Igor, Stumvoll, Michael, Campbell, Harry, van Duijn, Cornelia M., Gieger, Christian, Illig, Thomas, Ferrucci, Luigi, Pedersen, Nancy L., Pramstaller, Peter P., Boehnke, Michael, Frayling, Timothy M., Shuldiner, Alan R., Peyser, Patricia A., Kardia, Sharon L. R., Palmer, Lyle J., Penninx, Brenda W., Meneton, Pierre, Harris, Tamara B., Navis, Gerjan, Harst, Pim van der, Smith, George Davey, Forouhi, Nita G., Loos, Ruth J. F., Salomaa, Veikko, Soranzo, Nicole, Boomsma, Dorret I., Groop, Leif, Tuomi, Tiinamaija, Hofman, Albert, Munroe, Patricia B., Gudnason, Vilmundur, Siscovick, David S., Watkins, Hugh, Lecoeur, Cecile, Vollenweider, Peter, Franco-Cereceda, Anders, Eriksson, Per, Jarvelin, Marjo-Riitta, Stefansson, Kari, Hamsten, Anders, Nicholson, George, Karpe, Fredrik, Dermitzakis, Emmanouil T., Lindgren, Cecilia M., McCarthy, Mark I., Froguel, Philippe, Kaakinen, Marika A., Lyssenko, Valeriya, Watanabe, Richard M., Ingelsson, Erik, Florez, Jose C., Dupuis, Josée, Barroso, Inês, Morris, Andrew P., and Prokopenko, Inga

Published
2021
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6. Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.

Author

Postmus, Iris, Trompet, Stella, Deshmukh, Harshal A, Barnes, Michael R, Li, Xiaohui, Warren, Helen R, Chasman, Daniel I, Zhou, Kaixin, Arsenault, Benoit J, Donnelly, Louise A, Wiggins, Kerri L, Avery, Christy L, Griffin, Paula, Feng, QiPing, Taylor, Kent D, Li, Guo, Evans, Daniel S, Smith, Albert V, de Keyser, Catherine E, Johnson, Andrew D, de Craen, Anton JM, Stott, David J, Buckley, Brendan M, Ford, Ian, Westendorp, Rudi GJ, Slagboom, P Eline, Sattar, Naveed, Munroe, Patricia B, Sever, Peter, Poulter, Neil, Stanton, Alice, Shields, Denis C, O'Brien, Eoin, Shaw-Hawkins, Sue, Chen, Y-D Ida, Nickerson, Deborah A, Smith, Joshua D, Dubé, Marie Pierre, Boekholdt, S Matthijs, Hovingh, G Kees, Kastelein, John JP, McKeigue, Paul M, Betteridge, John, Neil, Andrew, Durrington, Paul N, Doney, Alex, Carr, Fiona, Morris, Andrew, McCarthy, Mark I, Groop, Leif, Ahlqvist, Emma, Welcome Trust Case Control Consortium, Bis, Joshua C, Rice, Kenneth, Smith, Nicholas L, Lumley, Thomas, Whitsel, Eric A, Stürmer, Til, Boerwinkle, Eric, Ngwa, Julius S, O'Donnell, Christopher J, Vasan, Ramachandran S, Wei, Wei-Qi, Wilke, Russell A, Liu, Ching-Ti, Sun, Fangui, Guo, Xiuqing, Heckbert, Susan R, Post, Wendy, Sotoodehnia, Nona, Arnold, Alice M, Stafford, Jeanette M, Ding, Jingzhong, Herrington, David M, Kritchevsky, Stephen B, Eiriksdottir, Gudny, Launer, Leonore J, Harris, Tamara B, Chu, Audrey Y, Giulianini, Franco, MacFadyen, Jean G, Barratt, Bryan J, Nyberg, Fredrik, Stricker, Bruno H, Uitterlinden, André G, Hofman, Albert, Rivadeneira, Fernando, Emilsson, Valur, Franco, Oscar H, Ridker, Paul M, Gudnason, Vilmundur, Liu, Yongmei, Denny, Joshua C, Ballantyne, Christie M, Rotter, Jerome I, Adrienne Cupples, L, Psaty, Bruce M, Palmer, Colin NA, Tardif, Jean-Claude, and Colhoun, Helen M

Subjects
Welcome Trust Case Control Consortium, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Pharmacogenetics, Polymorphism, Single Nucleotide, Cholesterol, LDL, Genome-Wide Association Study, Cholesterol, LDL, Polymorphism, Single Nucleotide
Abstract

Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response.

Published
2014

7. Co-occurrence of early diabetes-related complications in adolescents and young adults with type 1 diabetes: an observational cohort study

Author

Afkarian, Maryam, Amrhein, James, Beauregard, Natalie, Bell, Ronny, Bellatorre, Anna, Bloch, Clifford A., Bowlby, Deborah, D'Agostino, Ralph, Jr, Dabelea, Dana, Daniels, Stephen, Divers, Jasmin, Dolan, Lawrence M., Gaur, Vinod P., Goldstein, Maureen T., Greenbaum, Carla, Hamman, Richard F., Harting, Jessica, Henkin, Leora, Hirsch, Irl, Holmquist, Kim, Imperatore, Giuseppina, Isom, Scott, Jackson, Malaka, Kahn, Michael G., Kearns, Sue, Kim, Grace, Klingensmith, Georgeanna J., Klingsheim, Mary, Knight, Lisa, Koebnick, Corinna, Lawrence, Jean M., Li, Xia, Liese, Angela D., Linder, Barbara, Liu, Lenna L., Loots, Beth, Love-Osborne, Kathy, Maahs, David, Marcovina, Santica M., Mayer-Davis, Elizabeth J., Merchant, Anwar, Merjaneh, Lina, Morgan, Timothy, Mottl, Amy, Nandi-Munshi, Debika, Neff, John, Nelson, Bryce, Pascual, Michael, Pettitt, David J., Pierce, June, Pihoker, Catherine, Powell, Jeffrey, Reboussin, Beth, Rewers, Marian J., Reynolds, Kristi, Sauder, Katherine A, Saydah, Sharon H., Stafford, Jeanette, Standiford, Debra A., Strylewicz, Greg, Taplin, Craig, Testaverde, Lisa, Thomas, Joan, Wadwa, Paul, Wagenknecht, Lynne E., Wilkening, Greta, Williams, Carrie, Wright, Davene, Yi-Frazier, Joyce, Stafford, Jeanette M, Mayer-Davis, Elizabeth J, Jensen, Elizabeth T, Saydah, Sharon, Dolan, Lawrence M, Hamman, Richard F, Lawrence, Jean M, Marcovina, Santica, and D'Agostino, Ralph B, Jr

Published
2019
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8. Association of Low-Frequency and Rare Coding-Sequence Variants with Blood Lipids and Coronary Heart Disease in 56,000 Whites and Blacks

Author

Peloso, Gina M, Auer, Paul L, Bis, Joshua C, Voorman, Arend, Morrison, Alanna C, Stitziel, Nathan O, Brody, Jennifer A, Khetarpal, Sumeet A, Crosby, Jacy R, Fornage, Myriam, Isaacs, Aaron, Jakobsdottir, Johanna, Feitosa, Mary F, Davies, Gail, Huffman, Jennifer E, Manichaikul, Ani, Davis, Brian, Lohman, Kurt, Joon, Aron Y, Smith, Albert V, Grove, Megan L, Zanoni, Paolo, Redon, Valeska, Demissie, Serkalem, Lawson, Kim, Peters, Ulrike, Carlson, Christopher, Jackson, Rebecca D, Ryckman, Kelli K, Mackey, Rachel H, Robinson, Jennifer G, Siscovick, David S, Schreiner, Pamela J, Mychaleckyj, Josyf C, Pankow, James S, Hofman, Albert, Uitterlinden, Andre G, Harris, Tamara B, Taylor, Kent D, Stafford, Jeanette M, Reynolds, Lindsay M, Marioni, Riccardo E, Dehghan, Abbas, Franco, Oscar H, Patel, Aniruddh P, Lu, Yingchang, Hindy, George, Gottesman, Omri, Bottinger, Erwin P, Melander, Olle, Orho-Melander, Marju, Loos, Ruth JF, Duga, Stefano, Merlini, Piera Angelica, Farrall, Martin, Goel, Anuj, Asselta, Rosanna, Girelli, Domenico, Martinelli, Nicola, Shah, Svati H, Kraus, William E, Li, Mingyao, Rader, Daniel J, Reilly, Muredach P, McPherson, Ruth, Watkins, Hugh, Ardissino, Diego, Project, NHLBI GO Exome Sequencing, Zhang, Qunyuan, Wang, Judy, Tsai, Michael Y, Taylor, Herman A, Correa, Adolfo, Griswold, Michael E, Lange, Leslie A, Starr, John M, Rudan, Igor, Eiriksdottir, Gudny, Launer, Lenore J, Ordovas, Jose M, Levy, Daniel, Chen, Y-D Ida, Reiner, Alexander P, Hayward, Caroline, Polasek, Ozren, Deary, Ian J, Borecki, Ingrid B, Liu, Yongmei, Gudnason, Vilmundur, Wilson, James G, van Duijn, Cornelia M, Kooperberg, Charles, Rich, Stephen S, Psaty, Bruce M, Rotter, Jerome I, O’Donnell, Christopher J, Rice, Kenneth, Boerwinkle, Eric, Kathiresan, Sekar, and Cupples, L Adrienne

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Cardiovascular, Heart Disease, Clinical Research, Atherosclerosis, Heart Disease - Coronary Heart Disease, 1-Alkyl-2-acetylglycerophosphocholine Esterase, Adult, Aged, Alleles, Animals, Black People, Cholesterol, HDL, Cholesterol, LDL, Cohort Studies, Coronary Disease, Female, Gene Frequency, Genetic Association Studies, Genetic Code, Genetic Variation, Humans, Linear Models, Male, Mice, Mice, Inbred C57BL, Microtubule-Associated Proteins, Middle Aged, Phenotype, Sequence Analysis, DNA, Subtilisins, Triglycerides, White People, NHLBI GO Exome Sequencing Project, Medical and Health Sciences, Genetics & Heredity, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Low-frequency coding DNA sequence variants in the proprotein convertase subtilisin/kexin type 9 gene (PCSK9) lower plasma low-density lipoprotein cholesterol (LDL-C), protect against risk of coronary heart disease (CHD), and have prompted the development of a new class of therapeutics. It is uncertain whether the PCSK9 example represents a paradigm or an isolated exception. We used the "Exome Array" to genotype >200,000 low-frequency and rare coding sequence variants across the genome in 56,538 individuals (42,208 European ancestry [EA] and 14,330 African ancestry [AA]) and tested these variants for association with LDL-C, high-density lipoprotein cholesterol (HDL-C), and triglycerides. Although we did not identify new genes associated with LDL-C, we did identify four low-frequency (frequencies between 0.1% and 2%) variants (ANGPTL8 rs145464906 [c.361C>T; p.Gln121*], PAFAH1B2 rs186808413 [c.482C>T; p.Ser161Leu], COL18A1 rs114139997 [c.331G>A; p.Gly111Arg], and PCSK7 rs142953140 [c.1511G>A; p.Arg504His]) with large effects on HDL-C and/or triglycerides. None of these four variants was associated with risk for CHD, suggesting that examples of low-frequency coding variants with robust effects on both lipids and CHD will be limited.

Published
2014

10. Contemporary outcomes for arterial reconstruction with non-saphenous vein cryo-preserved conduits.

Author

Sanin, Gloria D., Negmadjanov, Ulugbek, Patterson, James W., Hamid, Rasikh N., Torosian, Taron, Stafford, Jeanette M., Sheehan, Maureen K., Goldman, Matthew P., Hurie, Justin, Edwards, Matthew S., and Velazquez, Gabriela

Abstract

Cryopreserved (CP) products are utilized during challenging cases when autogenous or prosthetic conduit use is not feasible. Despite decades of experience with cadaveric greater saphenous vein (GSV), there is limited available data regarding the outcomes and patency of other CP products, specifically arterial and deep venous grafts. This study was designed to evaluate outcomes of non-GSV CP conduits in patients undergoing urgent, emergent, and elective arterial reconstruction at our institution. We hypothesized that non-GSV CP allografts have adequate patency and outcomes and are therefore a feasible alternative to GSV in settings where autologous graft is unavailable or prosthetic grafts are contraindicated. This study was approved by the Institutional Review Board at our institution. We retrospectively reviewed charts of patients undergoing arterial reconstructions using CP conduits from 2010 to 2022. Data collected included demographics, comorbidities, smoking status, indications for surgery, indication for CP conduit use, anatomic reconstruction, urgency of procedure, and blood loss. Time-to-event outcomes included primary and secondary graft patency rates, follow-up amputations, and mortality; other complications included follow-up infection/reinfection and 30-day complications, including return to the operating room and perioperative mortality. Time-to-event analyses were evaluated using product-limit survival estimates. Of 96 identified patients receiving CP conduits, 56 patients received non-GSV conduits for 66 arterial reconstructions. The most common type of non-GSV CP product used was femoral artery (31 patients), followed by aorto-iliac artery (22 patients), and femoral vein (19 patients), with some patients receiving more than one reconstruction or CP product. Patients were mostly male (75%), with a mean age of 63.1 years and a mean body mass index of 26.7 kg/m2. Indications for CP conduit use included infection in 53 patients, hostile environment in 36 patients, contaminated field in 30 patients, tissue coverage concerns in 30 patients, inadequate conduit in nine patients, and patient preference in one patient. Notably, multiple patients had more than one indication. Most surgeries (95%) were performed in urgent or emergent settings. Supra-inguinal reconstructions were most common (53%), followed by extra-anatomic bypasses (47%). Thirty-day mortality occurred in 10 patients (19%). Fifteen patients (27%) required return to the operating room for indications related to the vascular reconstructions, with 10 (18%) cases being unplanned and five (9%) cases planned/staged. Overall survival at 6, 12, and 24 months was 80%, 68%, and 59%, respectively. Primary patency at 6, 12, and 24 months was 86%, 70%, and 62%, respectively. Amputation freedom at 6 months, 12 months, and 24 months was 98%, 95%, and 86%, respectively for non-traumatic indications. Non-GSV CP products may be used in complex arterial reconstructions when autogenous or prosthetic options are not feasible or available. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Uric Acid Is Not Associated With Cardiovascular Health in Youth With Type 1 Diabetes: SEARCH for Diabetes in Youth Study.

Author

South, Andrew M, Rigdon, Joseph, Voruganti, Saroja, Stafford, Jeanette M, Dabelea, Dana, Marcovina, Santica, Mottl, Amy K, Pihoker, Cate, Urbina, Elaine M, and Jensen, Elizabeth T

Subjects
TYPE 1 diabetes, URIC acid, CARDIOVASCULAR system
Abstract

Context Uric acid's role in cardiovascular health in youth with type 1 diabetes is unknown. Objective Investigate whether higher uric acid is associated with increased blood pressure (BP) and arterial stiffness over time in adolescents and young adults with type 1 diabetes and if overweight/obesity modifies this relationship. Methods Longitudinal analysis of data from adolescents and young adults with type 1 diabetes from 2 visits (mean follow up 4.6 years) in the SEARCH for Diabetes in Youth multicenter prospective cohort study from 2007 to 2018. Our exposure was uric acid at the first visit and our outcome measures were the change in BP, pulse wave velocity (PWV), and augmentation index between visits. We used multivariable linear mixed-effects models and assessed for effect modification by overweight/obesity. Results Of 1744 participants, mean age was 17.6 years, 49.4% were female, 75.9% non-Hispanic White, and 45.4% had a follow-up visit. Mean uric acid was 3.7 mg/dL (SD 1.0). Uric acid was not associated with increased BP, PWV-trunk, or augmentation index over time. Uric acid was marginally associated with PWV-upper extremity (β =.02 m/s/year, 95% CI 0.002 to 0.04). The magnitude of this association did not differ by overweight/obesity status. Conclusion Among adolescents and young adults with type 1 diabetes, uric acid was not consistently associated with increased BP or arterial stiffness over time. These results support findings from clinical trials in older adults with diabetes showing that lowering uric acid levels does not improve cardiovascular outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Diabetes Complications and Cognitive Function in Young Adults with Youth-Onset Type 1 or Type 2 Diabetes: The SEARCH for Diabetes in Youth Study

Author

Shapiro, Allison L. B., primary, Bellatorre, Anna, additional, Dabelea, Dana, additional, Stafford, Jeanette M., additional, D’Agostino, Ralph, additional, Shah, Amy S., additional, Urbina, Elaine M., additional, Barrett, Catherine E., additional, Pihoker, Catherine, additional, Marcovina, Santica, additional, Liese, Angela D., additional, Mottl, Amy K., additional, Jensen, Elizabeth T., additional, and Wilkening, Greta, additional

Published
2023
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15. Preconception Counseling in Women With Diabetes: The SEARCH for Diabetes in Youth Study

Author

Roberts, Alissa J., primary, Sauder, Katherine, additional, Stafford, Jeanette M., additional, Malik, Faisal S., additional, Pihoker, Catherine, additional, Boghossian, Nansi S., additional, Ehrlich, Shelley, additional, Pettitt, David J., additional, Dabelea, Dana, additional, Bellatorre, Anna, additional, D’Agostino, Ralph, additional, and Jensen, Elizabeth T., additional

Published
2023
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17. Genome-wide association study of kidney function decline in individuals of European descent

Author

Gorski, Mathias, Tin, Adrienne, Garnaas, Maija, McMahon, Gearoid M., Chu, Audrey Y., Tayo, Bamidele O., Pattaro, Cristian, Teumer, Alexander, Chasman, Daniel I., Chalmers, John, Hamet, Pavel, Tremblay, Johanne, Woodward, Marc, Aspelund, Thor, Eiriksdottir, Gudny, Gudnason, Vilmundur, Harris, Tamara B., Launer, Lenore J., Smith, Albert V., Mitchell, Braxton D., O'Connell, Jeffrey R., Shuldiner, Alan R., Coresh, Josef, Li, Man, Freudenberger, Paul, Hofer, Edith, Schmidt, Helena, Schmidt, Reinhold, Holliday, Elizabeth G., Mitchell, Paul, Wang, Jie Jin, de Boer, Ian H., Li, Guo, Siscovick, David S., Kutalik, Zoltan, Corre, Tanguy, Vollenweider, Peter, Waeber, Gérard, Gupta, Jayanta, Kanetsky, Peter A., Hwang, Shih-Jen, Olden, Matthias, Yang, Qiong, de Andrade, Mariza, Atkinson, Elizabeth J., Kardia, Sharon L.R., Turner, Stephen T., Stafford, Jeanette M., Ding, Jingzhong, Liu, Yongmei, Barlassina, Cristina, Cusi, Daniele, Salvi, Erika, Staessen, Jan A., Ridker, Paul M., Grallert, Harald, Meisinger, Christa, Müller-Nurasyid, Martina, Krämer, Bernhard K., Kramer, Holly, Rosas, Sylvia E., Nolte, Ilja M., Penninx, Brenda W., Snieder, Harold, Fabiola Del Greco, M., Franke, Andre, Nöthlings, Ute, Lieb, Wolfgang, Bakker, Stephan J.L., Gansevoort, Ron T., van der Harst, Pim, Dehghan, Abbas, Franco, Oscar H., Hofman, Albert, Rivadeneira, Fernando, Sedaghat, Sanaz, Uitterlinden, André G., Coassin, Stefan, Haun, Margot, Kollerits, Barbara, Kronenberg, Florian, Paulweber, Bernhard, Aumann, Nicole, Endlich, Karlhans, Pietzner, Mike, Völker, Uwe, Rettig, Rainer, Chouraki, Vincent, Helmer, Catherine, Lambert, Jean-Charles, Metzger, Marie, Stengel, Benedicte, Lehtimäki, Terho, Lyytikäinen, Leo-Pekka, Raitakari, Olli, Johnson, Andrew, Parsa, Afshin, Bochud, Murielle, Heid, Iris M., Goessling, Wolfram, Köttgen, Anna, Linda Kao, W.H., Fox, Caroline S., and Böger, Carsten A.

Published
2015
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18. COMPASS-CP: An Electronic Application to Capture Patient-Reported Outcomes to Develop Actionable Stroke and Transient Ischemic Attack Care Plans

Author

Duncan, Pamela W., Abbott, Rica M., Rushing, Scott, Johnson, Anna M., Condon, Christina N., Lycan, Sarah L., Lutz, Barbara J., Cummings, Doyle M., Pastva, Amy M., D’Agostino, Ralph B., Jr, Stafford, Jeanette M., Amoroso, Robert M., Jones, Sara B., Psioda, Matthew A., Gesell, Sabina B., Rosamond, Wayne D., Prvu-Bettger, Janet, Sissine, Mysha E., Boynton, Mark D., and Bushnell, Cheryl D.

Published
2018
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19. Ethnic and Sex Differences in Ownership of Preventive Health Equipment among Rural Older Adults with Diabetes

Author

Bell, Ronny A., Arcury, Thomas A., and Stafford, Jeanette M.

Abstract

Context: Diabetes self-management is important for achieving successful health outcomes. Different levels of self-management have been reported among various populations, though little is known about ownership of equipment that can enhance accomplishment of these tasks. Purpose: This study examined diabetes self-management equipment ownership among rural older adults. Methods: Participants included African American, American Indian, and white men and women 65 years of age and older. Data included equipment ownership overall and by ethnicity and sex across diabetes self-management domains (glucose monitoring, foot care, medication adherence, exercise, and diet). Associations between equipment ownership and demographic and health characteristics were assessed using logistic regression. Findings: Equipment ownership ranged from 85.0% for blood glucose meters to less than 11% for special socks, modified dishes, and various forms of home exercise equipment. Equipment ownership was associated with ethnicity, living arrangements, mobility, poverty status, and formal education. Conclusions: Rural older adults with diabetes are at risk because they lack equipment to perform some self-management tasks. Providers should be sensitive to and assist patients in overcoming this barrier.

Published
2007
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20. The Association of Health and Functional Status with Private and Public Religious Practice among Rural, Ethnically Diverse, Older Adults with Diabetes

Author

Arcury, Thomas A., Stafford, Jeanette M., Bell, Ronny A., Golden, Shannon L., Snively, Beverly M., and Quandt, Sara A.

Abstract

Purpose: This analysis describes the association of health and functional status with private and public religious practice among ethnically diverse (African American, Native American, white) rural older adults with diabetes. Methods: Data were collected using a population-based, cross-sectional, stratified, random sample survey of 701 community-dwelling elders with diabetes in two rural North Carolina counties. Outcome measures were private religious practice, church attendance, religious support provided, and religious support received. Correlates included religiosity, health and functional status, and personal characteristics. Statistical significance was assessed using multiple linear regression and logistic regression models. Findings: These rural elders had high levels of religious belief, and private and public religious practice. Religiosity was associated with private and public religious practice. Health and functional status were not associated with private religious practice, but they were associated with public religious practice, such that those with limited functional status participated less in public religious practice. Ethnicity was associated with private religious practice: African Americans had higher levels of private religious practice than Native Americans or whites, while Native Americans had higher levels than whites. Conclusions: Variation in private religious practice among rural older adults is related to personal characteristics and religiosity, while public religious practice is related to physical health, functional status, and religiosity. Declining health may affect the social integration of rural older adults by limiting their ability to participate in a dominant social institution.

Published
2007
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21. Physical Activity among Rural Older Adults with Diabetes

Author

Arcury, Thomas A., Snively, Beverly M., Bell, Ronny A., Smith, Shannon L., Stafford, Jeanette M., Wetmore-Arkader, Lindsay K., and Quandt, Sara A.

Abstract

Purpose: This analysis describes physical activity levels and factors associated with physical activity in an ethnically diverse (African American, Native American, white) sample of rural older adults with diabetes. Method: Data were collected using a population-based, cross-sectional stratified random sample survey of 701 community-dwelling elders with diabetes completed in 2 rural North Carolina counties. Outcome measures were as follows: first, physical activity in the past year, and second, days physically active in the prior week (0-7). Potential correlates included personal and health characteristics and were evaluated for statistical significance using logistic regression models. Findings: About half (52.5%) of the participants stated that they had engaged in physical activity in the past year. Among those, 42.5% stated that they had no days with at least 30 minutes of continuous physical activity in the prior week, while 21.5% reported daily physical activity. Common activities were walking and housework. Correlates of physical activity in the past year and days active in the prior week included measures of physical health and mobility. Conclusions: Physical activity in this ethnically diverse sample of rural elders with diabetes is limited. Effort must be invested to increase physical activity in these groups.

Published
2006
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22. New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 Individuals

Author

Kraja, Aldi T., Cook, James P., Warren, Helen R., Surendran, Praveen, Liu, Chunyu, Evangelou, Evangelos, Manning, Alisa K., Grarup, Niels, Drenos, Fotios, Sim, Xueling, Smith, Albert Vernon, Amin, Najaf, Blakemore, Alexandra I.F., Bork-Jensen, Jette, Brandslund, Ivan, Farmaki, Aliki-Eleni, Fava, Cristiano, Ferreira, Teresa, Herzig, Karl-Heinz, Giri, Ayush, Giulianini, Franco, Grove, Megan L., Guo, Xiuqing, Harris, Sarah E., Have, Christian T., Havulinna, Aki S., Zhang, He, Jørgensen, Marit E., Käräjämäki, AnneMari, Kooperberg, Charles, Linneberg, Allan, Little, Louis, Liu, Yongmei, Bonnycastle, Lori L., Lu, Yingchang, Mägi, Reedik, Mahajan, Anubha, Malerba, Giovanni, Marioni, Riccardo E., Mei, Hao, Menni, Cristina, Morrison, Alanna C., Padmanabhan, Sandosh, Palmas, Walter, Poveda, Alaitz, Rauramaa, Rainer, Rayner, Nigel William, Riaz, Muhammad, Rice, Ken, Richard, Melissa A., Smith, Jennifer A., Southam, Lorraine, Stančáková, Alena, Stirrups, Kathleen E., Tragante, Vinicius, Tuomi, Tiinamaija, Tzoulaki, Ioanna, Varga, Tibor V., Weiss, Stefan, Yiorkas, Andrianos M., Young, Robin, Zhang, Weihua, Barnes, Michael R., Cabrera, Claudia P., Gao, He, Boehnke, Michael, Boerwinkle, Eric, Chambers, John C., Connell, John M., Christensen, Cramer K., de Boer, Rudolf A., Deary, Ian J., Dedoussis, George, Deloukas, Panos, Dominiczak, Anna F., Dörr, Marcus, Joehanes, Roby, Edwards, Todd L., Esko, Tõnu, Fornage, Myriam, Franceschini, Nora, Franks, Paul W., Gambaro, Giovanni, Groop, Leif, Hallmans, Göran, Hansen, Torben, Hayward, Caroline, Heikki, Oksa, Ingelsson, Erik, Tuomilehto, Jaakko, Jarvelin, Marjo-Riitta, Kardia, Sharon L.R., Karpe, Fredrik, Kooner, Jaspal S., Lakka, Timo A., Langenberg, Claudia, Lind, Lars, Loos, Ruth J.F., Laakso, Markku, McCarthy, Mark I., Melander, Olle, Mohlke, Karen L., Morris, Andrew P., Palmer, Colin N.A., Pedersen, Oluf, Polasek, Ozren, Poulter, Neil R., Province, Michael A., Psaty, Bruce M., Ridker, Paul M., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Sever, Peter J., Skaaby, Tea, Stafford, Jeanette M., Starr, John M., van der Harst, Pim, van der Meer, Peter, van Duijn, Cornelia M., Vergnaud, Anne-Claire, Gudnason, Vilmundur, Wareham, Nicholas J., Wilson, James G., Willer, Cristen J., Witte, Daniel R., Zeggini, Eleftheria, Saleheen, Danish, Butterworth, Adam S., Danesh, John, Asselbergs, Folkert W., Wain, Louise V., Ehret, Georg B., Chasman, Daniel I., Caulfield, Mark J., Elliott, Paul, Lindgren, Cecilia M., Levy, Daniel, Newton-Cheh, Christopher, Munroe, Patricia B., and Howson, Joanna M.M.

Published
2017
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23. Primary and Specialty Medical Care among Ethnically Diverse, Older Rural Adults with Type 2 Diabetes: The ELDER Diabetes Study

Author

Bell, Ronny A., Quandt, Sara A., Arcury, Thomas A., Snively, Beverly M., Stafford, Jeanette M., Smith, Shannon L., and Skelly, Anne H.

Abstract

Purpose: Residents in rural communities in the United States, especially ethnic minority group members, have limited access to primary and specialty health care that is critical for diabetes management. This study examines primary and specialty medical care utilization among a rural, ethnically diverse, older adult population with diabetes. Methods: Data were drawn from a cross-sectional face-to-face survey of randomly selected African American (n = 220), Native American (n = 181), and white (n = 297) Medicare beneficiaries more than or equal to 65 years old with diabetes in 2 rural counties in central North Carolina. Participants were asked about utilization of a primary care doctor and of specialists (nutritionist, diabetes specialist, eye doctor, bladder specialist, kidney specialist, heart specialist, foot specialist) in the past year. Findings: Virtually all respondents (99.0%) reported having a primary care doctor and seeing that doctor in the past year. About 42% reported seeing a doctor for diabetes-related care. On average, participants reported seeing 2 specialists in the past year, and 54% reported seeing more than 1 specialist. Few reported seeing a diabetes specialist (5.7%), nutritionist (10.9%), or kidney specialist (17.5%). African Americans were more likely than others to report seeing a foot specialist (P less than 0.01), while men were more likely than women to have seen a bladder specialist (P = 0.02), kidney specialist (P = 0.001), and heart specialist (P = 0.004), after adjusting for potential confounders. Predictors of the number of specialists seen include gender, education, poverty status, diabetes medication use, and self-rated health. Conclusions: These data indicate low utilization of specialty diabetes care providers across ethnic groups and reflect the importance of primary care providers in diabetes care in rural areas.

Published
2005
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25. Association of Type 1 Diabetes vs Type 2 Diabetes Diagnosed During Childhood and Adolescence With Complications During Teenage Years and Young Adulthood

Author

Dabelea, Dana, Stafford, Jeanette M., Mayer-Davis, Elizabeth J., D’Agostino, Ralph, Jr, Dolan, Lawrence, Imperatore, Giuseppina, Linder, Barbara, Lawrence, Jean M., Marcovina, Santica M., Mottl, Amy K., Black, Mary Helen, Pop-Busui, Rodica, Saydah, Sharon, Hamman, Richard F., and Pihoker, Catherine

Published
2017
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33. Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Author

Lagou, Vasiliki, Mägi, Reedik, Hottenga, Jouke-Jan, Grallert, Harald, Perry, John R B, Bouatia-Naji, Nabila, Marullo, Letizia, Rybin, Denis, Jansen, Rick, Min, Josine L, Dimas, Antigone S, Ulrich, Anna, Zudina, Liudmila, Gådin, Jesper R, Jiang, Longda, Faggian, Alessia, Bonnefond, Amélie, Fadista, Joao, Stathopoulou, Maria G, Isaacs, Aaron, Willems, Sara M, Navarro, Pau, Tanaka, Toshiko, Jackson, Anne U, Montasser, May E, O'Connell, Jeff R, Bielak, Lawrence F, Webster, Rebecca J, Saxena, Richa, Stafford, Jeanette M, et al, and University of Zurich

Subjects
1300 General Biochemistry, Genetics and Molecular Biology, 10265 Clinic for Endocrinology and Diabetology, 610 Medicine & health, 1600 General Chemistry, 3100 General Physics and Astronomy
Published
2021
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34. Glycemic control is associated with dyslipidemia over time in youth with type 2 diabetes: The SEARCH for diabetes in youth study

Author

Brady, Ryan P., primary, Shah, Amy S., additional, Jensen, Elizabeth T., additional, Stafford, Jeanette M., additional, D'Agostino, Ralph B., additional, Dolan, Lawrence M., additional, Knight, Lisa, additional, Imperatore, Giuseppina, additional, Turley, Christine B., additional, Liese, Angela D., additional, Urbina, Elaine M., additional, Lawrence, Jean M., additional, Pihoker, Catherine, additional, Marcovina, Santica, additional, and Dabelea, Dana, additional

Published
2021
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35. Disparities in Hemoglobin A1c Testing During the Transition to Adulthood and Association With Diabetes Outcomes in Youth-Onset Type 1 and Type 2 Diabetes: The SEARCH for Diabetes in Youth Study

Author

Sauder, Katherine A, primary, Stafford, Jeanette M, primary, Ehrlich, Shelley, primary, Lawrence, Jean M, primary, Liese, Angela D, primary, Marcovina, Santica, primary, Mottl, Amy K, primary, Pihoker, Catherine, primary, Saydah, Sharon, primary, Shah, Amy S, primary, Jr, Ralph B. D’Agostino, primary, Dabelea, Dana, primary, and Group, the SEARCH for Diabetes in Youth Study, primary

Published
2021
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36. Disparities in Hemoglobin A1c Testing During the Transition to Adulthood and Association With Diabetes Outcomes in Youth-Onset Type 1 and Type 2 Diabetes: The SEARCH for Diabetes in Youth Study

Author

Sauder, Katherine A., primary, Stafford, Jeanette M., additional, Ehrlich, Shelley, additional, Lawrence, Jean M., additional, Liese, Angela D., additional, Marcovina, Santica, additional, Mottl, Amy K., additional, Pihoker, Catherine, additional, Saydah, Sharon, additional, Shah, Amy S., additional, D’Agostino, Ralph B., additional, and Dabelea, Dana, additional

Published
2021
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37. Increase in Prevalence of Diabetic Ketoacidosis at Diagnosis Among Youth With Type 1 Diabetes: The SEARCH for Diabetes in Youth Study

Author

Jensen, Elizabeth T., primary, Stafford, Jeanette M., additional, Saydah, Sharon, additional, D’Agostino, Ralph B., additional, Dolan, Lawrence M., additional, Lawrence, Jean M., additional, Marcovina, Santica, additional, Mayer-Davis, Elizabeth J., additional, Pihoker, Catherine, additional, Rewers, Arleta, additional, and Dabelea, Dana, additional

Published
2021
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41. Predictors of falls in a multiethnic population of older rural adults with diabetes

Author

Quandt, Sara A., Stafford, Jeanette M., Bell, Ronny A., Smith, Shannon L., Snively, Beverly M., and Arcury, Thomas A.

Subjects
Falls (Accidents) -- Research, Diabetes -- Research, Gerontology -- Research, Health, Seniors
Abstract

Background. Falls are a recognized danger for older adults with diabetes. Persons in rural communities with diabetes may face additional risks from falling due to environmental and activity differences. Methods. Data were obtained in a cross-sectional survey of a stratified random sample of 691 community-dwelling adults (42.7% white, 31.4% African American, and 25.9% Native American) at least 65 years old with two or more Medicare claims for diabetes in 1998-2000, living in two rural counties in North Carolina. Falls data were self-reported for the previous year. Demographic data, foot-related symptoms, diabetes medications, and other health characteristics were reported. Results. Three hundred two persons (43.7%) reported falling at least once, including 171 (26.2%) who experienced two or more (frequent) falls. Frequent fallers were more likely to be male (odds ratio [OR] = 1.76; 95% confidence interval [CI] = 1.17, 2.66), report tingling or numbness in feet (OR = 1.75; 95% CI = 1.13, 2.70), have had a stroke (OR = 1.81: 95% CI = 1.19, 2.76), have longer duration of diabetes (OR = 1.21; 95% CI= 1.00, 1.47), have lower physical functioning (OR = 0.97; 95% CI = 0.96. 0.99) and mobility (OR = 0.89; 95% CI = 0.82, 0.96), and take a greater number of prescription medications (OR = 1.07; 95% CI= 1.01, 1.13). Conclusions. For rural older adults with diabetes, falls history should be screened to identify those at risk. Further research should investigate unique environmental factors contributing to falls for rural elderly persons.

Published
2006

42. Increase in Prevalence of Diabetic Ketoacidosis at Diagnosis Among Youth With Type 1 Diabetes: The SEARCH for Diabetes in Youth Study

Author

Jensen, Elizabeth T, primary, Stafford, Jeanette M, primary, Saydah, Sharon, primary, Jr, Ralph B D'Agostino,, primary, Dolan, Lawrence M, primary, Lawrence, Jean M, primary, Marcovina, Santica, primary, Mayer-Davis, Elizabeth J, primary, Pihoker, Catherine, primary, Rewers, Arleta, primary, and Dabelea, Dana, primary

Published
2021
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43. 963-P: Preconception Counseling in Women with Diabetes: SEARCH for Diabetes in Youth Study

Author

ROBERTS, ALISSA J., primary, SAUDER, KATHERINE A., additional, STAFFORD, JEANETTE M., additional, MALIK, FAISAL, additional, PIHOKER, CATHERINE, additional, BOGHOSSIAN, NANSI S., additional, EHRLICH, SHELLEY R., additional, PETTITT, DAVID J., additional, DABELEA, DANA, additional, BELLATORRE, ANNA, additional, DAGOSTINO, RALPH, additional, and JENSEN, ELIZABETH T., additional

Published
2021
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44. Cognitive Function in Adolescents and Young Adults With Youth-Onset Type 1 Versus Type 2 Diabetes: The SEARCH for Diabetes in Youth Study

Author

Shapiro, Allison L.B., primary, Dabelea, Dana, additional, Stafford, Jeanette M., additional, D’Agostino, Ralph, additional, Pihoker, Catherine, additional, Liese, Angela D., additional, Shah, Amy S., additional, Bellatorre, Anna, additional, Lawrence, Jean M., additional, Henkin, Leora, additional, Saydah, Sharon, additional, and Wilkening, Greta, additional

Published
2021
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45. 155-OR: Diabetes Complications and Cognitive Function in Youth with Type 1 and Type 2 Diabetes: The SEARCH for Diabetes in Youth Study

Author

SHAPIRO, ALLISON, primary, BELLATORRE, ANNA, additional, DABELEA, DANA, additional, STAFFORD, JEANETTE M., additional, DAGOSTINO, RALPH, additional, SHAH, AMY S., additional, URBINA, ELAINE M., additional, BARRETT, CATHERINE E., additional, PIHOKER, CATHERINE, additional, MARCOVINA, SANTICA M., additional, LIESE, ANGELA D., additional, MOTTL, AMY K., additional, JENSEN, ELIZABETH T., additional, and WILKENING, GRETA, additional

Published
2021
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47. Cognitive Function in Adolescents and Young Adults With Youth-Onset Type 1 Versus Type 2 Diabetes: The SEARCH for Diabetes in Youth Study

Author

Shapiro, Allison L. B., primary, Dabelea, Dana, primary, Stafford, Jeanette M., primary, Jr, Ralph D’Agostino, primary, Pihoker, Catherine, primary, Liese, Angela D., primary, Shah, Amy S., primary, Bellatorre, Anna, primary, Lawrence, Jean M., primary, Henkin, Leora, primary, Saydah, Sharon, primary, Wilkening, Greta, primary, and Group, SEARCH for Diabetes in Youth Study, primary

Published
2021
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48. Diabetes foot self-care practices in a rural, triethnic population

Author

Bell, Ronny A., Arcury, Thomas A., Snively, Beverly M., Smith, Shannon L., Stafford, Jeanette M., Dohanish, Ron, and Quandt, Sara A.

Subjects
Education, Care and treatment, Health aspects, Forecasts and trends, Market trend/market analysis, Patient education -- Forecasts and trends -- Health aspects, Diabetes mellitus -- Care and treatment, African Americans -- Health aspects -- Education -- Forecasts and trends, Diabetic foot -- Care and treatment, Diabetes -- Care and treatment
Abstract

Purpose The purposes of this study were to assess the level of foot self-care performed in a rural, multiethnic population of older adults and to identify factors associated with foot [...]

Published
2005

49. Abstract P059: Association Of Uric Acid With Change In Arterial Stiffness And Blood Pressure Over Time In Type 1 Diabetes Mellitus: The SEARCH For Diabetes In Youth Study

Author

South, Andrew M, primary, Rigdon, Joseph, additional, Stafford, Jeanette M, additional, Dabelea, Dana, additional, Lawrence, Jean, additional, Marcovina, Santica M, additional, Mottl, Amy, additional, Pihoker, Catherine, additional, Voruganti, Saroja, additional, Urbina, Elaine M, additional, and Jensen, Elizabeth T, additional

Published
2020
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50. 280-OR: Medical Nutrition Therapy and Glycemic Control in Youth-Onset Diabetes: SEARCH for Diabetes in Youth Study

Author

SAUDER, KATHERINE A., primary, STAFFORD, JEANETTE M., additional, THE, NATALIE S., additional, MAYER-DAVIS, ELIZABETH J., additional, THOMAS, JOAN, additional, LAWRENCE, JEAN M., additional, KIM, GRACE, additional, SIEGEL, KAREN R., additional, JENSEN, ELIZABETH T., additional, SHAH, AMY S., additional, DAGOSTINO, RALPH, additional, and DABELEA, DANA, additional

Published
2020
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