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116 results on '"Stanevicha, Valda"'

1. The HyperPed-COVID international registry: Impact of age of onset, disease presentation and geographical distribution on the final outcome of MIS-C

Author

Caorsi, Roberta, Consolaro, Alessandro, Speziani, Camilla, Sozeri, Betul, Ulu, Kadir, Faugier-Fuentes, Enrique, Menchaca-Aguayo, Hector, Ozen, Seza, Sener, Seher, Akhter Rahman, Shahana, Imnul Islam, Mohammad, Haerynck, Filomeen, Simonini, Gabriele, Mastri, Mariel Viviana, Avcin, Tadej, Sršen, Saša, de Albuquerque Pedrosa Fernandes, Taciana, Stanevicha, Valda, Vojinovic, Jelena, Sobh, Ali, Fingerhutova, Sarka, Minxova, Lenka, Gagro, Alenka, Rodrigues Fonseca, Adriana, Pandya, Devang, Varbanova, Boriana, Sánchez-Manubens, Judith, Ganeva, Margarita, Montin, Davide, Boyarchuk, Oksana, Minghini, Andrea, Bracaglia, Claudia, Brogan, Paul, Candotti, Fabio, Cattalini, Marco, Meyts, Isabelle, Minoia, Francesca, Taddio, Andrea, Wouters, Carine, De Benedetti, Fabrizio, Bovis, Francesca, Ravelli, Angelo, Ruperto, Nicolino, Gattorno, Marco, Bilginer, Yelda, Laila, Kamrul, Islam, Mohammed Mahbubul, Meertens, Bram, Hoste, Levi, Dehoorne, Joke, Schelstraete, Petra, Vandekerckhove, Kristof, Willems, Jef, Matthijs, Inge, Filocamo e Gisella Beatrice Beretta, Giovanni, Magalhaes, Claudia Saad, Chubata, Oksana, Ricci, Francesca, Vukovic, Antonija, Temelkova, Katya, Avramovic, Mojca Zajc, Emersic, Nina, Bizjak, Masa, Vesel, Tina, Rodrigues, Marta Felix, Gasparello de Almeida, Rozana, Lukjanovica, Kristine, Elnagdy, Marwa H., Soliman, Ahmed, Terifajova, Eva, Brejchova, Ivana, Magner, Martin, Myrup, Charlotte, Vougiouka, Olga, Jelusic, Marija, La Torre, Francesco, Rigante, Donato, Maggio, Maria Cristina, Verdoni, Lucio, Rubio-Perez, Nadina, Cornejo, Gabriel Vega, Villarreal Trevino, Ana Victoria, Brito, Iva, Oliveira-Ramos, Filipa, Alexeeva, Ekaterina, Chasnyk, Vyacheslav, Arkachaisri, Thaschawee, Boyko, Yaryna, Vyzhga, Yulia, and Samsonenko, Svitlana

Published
2024
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2. Differences Sustained Between Diffuse and Limited Forms of Juvenile Systemic Sclerosis in an Expanded International Cohort

Author

Foeldvari, Ivan, Klotsche, Jens, Kasapcopur, Ozgur, Adrovic, Amra, Terreri, Maria Teresa, Sakamoto, Ana Paula, Stanevicha, Valda, Sztajnbok, Flavio, Anton, Jordi, Feldman, Brian, Alexeeva, Ekaterina, Katsicas, Maria, Smith, Vanessa, Avcin, Tadej, Marrani, Edoardo, Kostik, Mikhail, Lehman, Thomas, Sifuentes‐Giraldo, Walter‐Alberto, Vasquez‐Canizares, Natalia, Appenzeller, Simone, Janarthanan, Mahesh, Moll, Monika, Nemcova, Dana, Patwardhan, Anjali, Santos, Maria Jose, Sawhney, Sujata, Schonenberg‐Meinema, Dieneke, Battagliotti, Cristina, Berntson, Lillemor, Bica, Blanca, Brunner, Jürgen, Costa‐Reis, Patricia, Eleftheriou, Despina, Harel, Liora, Horneff, Gerd, Kaiser, Daniela, Kallinich, Tilmann, Lazarevic, Dragana, Minden, Kirsten, Nielsen, Susan, Nuruzzaman, Farzana, Uziel, Yosef, Helmus, Nicola, and Torok, Kathryn S.

Published
2022
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3. Development and Initial Validation of the Macrophage Activation Syndrome/Primary Hemophagocytic Lymphohistiocytosis Score, a Diagnostic Tool that Differentiates Primary Hemophagocytic Lymphohistiocytosis from Macrophage Activation Syndrome

Author

Abinun, Mario, Aggarwal, Amita, Akikusa, Jonathan, Al-Mayouf, Sulaiman, Alessio, Maria, Anton, Jordi, Apaz, Maria Teresa, Astigarraga, Itziar, Avcin, Tadej, Ayaz, Nuray Aktay, Barone, Patrizia, Bica, Bianca, Bolt, Isabel, Bovis, Francesca, Breda, Luciana, Chasnyk, Vyacheslav, Cimaz, Rolando, Corona, Fabrizia, Cron, Randy Q., Cuttica, Ruben, Davì, Sergio, Davidsone, Zane, De Cunto, Carmen, De Inocencio, Jaime, Demirkaya, Erkan, Eisenstein, Eli M., Enciso, Sandra, Espada, Graciela, Fischbach, Michel, Frosch, Michael, Gallizzi, Romina, Gamir, Maria Luz, Gao, Yi-Jin, Griffin, Thomas, Grom, Alexei, Hashad, Soad, Hennon, Teresa, Henter, Jan-Inge, Horne, AnnaCarin, Horneff, Gerd, Huasong, Zeng, Huber, Adam, Ilowite, Norman, Insalaco, Antonella, Ioseliani, Maka, Jeng, Michael, Kapović, Agneza Marija, Kasapcopur, Ozgur, Khubchandani, Raju, Kitoh, Toshiyuki, Koné-Paut, Isabelle, de Oliveira, Sheila Knupp Feitosa, Lattanzi, Bianca, Lehmberg, Kai, Lepore, Loredana, Li, Caifeng, Lipton, Jeffrey M., Magni-Manzoni, Silvia, Maritsi, Despoina, Martini, Alberto, McCurdy, Deborah, Merino, Rosa, Micalizzi, Concetta, Miettunen, Paivi, Minoia, Francesca, Mulaosmanovic, Velma, Nichols, Kim E., Nielsen, Susan, Ozen, Seza, Pal, Priyankar, Prahalad, Sampath, Ravelli, Angelo, Rigante, Donato, Rumba-Rozenfelde, Ingrida, Ruperto, Nicolino, Russo, Ricardo, Magalhães, Claudia Saad, Sanner, Helga, Sewairi, Wafaa Mohamed Saad, Shenoi, Susan, Artur Silva, Clovis, Stanevicha, Valda, Sterba, Gary, Stine, Kimo C., Susic, Gordana, Sztajnbok, Flavio, Takei, Syuji, Trauzeddel, Ralf, Tsitsami, Elena, Unsal, Erbil, Uziel, Yosef, Vougiouka, Olga, Wallace, Carol A., Weaver, Lehn, E. Weiss, Jennifer, Weitzman, Sheila, Wouters, Carine, Wulffraat, Nico, Zletni, Mabruka, Arico, Maurizio, Egeler, R. Maarten, Filipovich, Alexandra H., Gadner, Helmut, Imashuku, Shinsaku, Janka, Gritta, Ladisch, Stephan, McClain, Ken L., and Webb, David

Published
2017
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4. Ten-year safety and clinical benefit from open-label etanercept treatment in children and young adults with juvenile idiopathic arthritis.

Author

Vojinović, Jelena, Foeldvari, Ivan, Dehoorne, Joke, Panaviene, Violeta, Susic, Gordana, Horneff, Gerd, Stanevicha, Valda, Kobusinska, Katarzyna, Zuber, Zbigniew, Dobrzyniecka, Bogna, Akikusa, Jonathan, Avcin, Tadej, Borlenghi, Cecilia, Arthur, Edmund, Tatulych, Svitlana Y, Zang, Chuanbo, Tsekouras, Vassilis, Vlahos, Bonnie, Martini, Alberto, and Ruperto, Nicolino

Subjects
DRUG efficacy, HODGKIN'S disease, CLINICAL trials, ANTI-inflammatory agents, JUVENILE idiopathic arthritis, ANTIRHEUMATIC agents, INFECTION, DESCRIPTIVE statistics, RESEARCH funding, DRUG side effects, PATIENT safety, DISEASE remission, EVALUATION, CHILDREN, ADOLESCENCE
Abstract

Objectives CLIPPER2 was an 8-year, open-label extension of the phase 3b, 2-year CLIPPER study on the safety and efficacy of etanercept in patients with JIA, categorized as extended oligoarticular arthritis (eoJIA), enthesitis-related arthritis (ERA) or PsA. Methods Participants with eoJIA (2–17 years old), ERA or PsA (each 12–17 years old) who received ≥1 etanercept dose (0.8 mg/kg weekly; maximum 50 mg) in CLIPPER could enter CLIPPER2. Primary end point was occurrence of malignancy. Efficacy assessments included proportions achieving JIA ACR 30/50/70/90/100 criteria and ACR inactive disease criteria, and clinical remission (ACR criteria) or Juvenile Arthritis DAS (JADAS) ≤1. Results Overall, 109/127 (86%) CLIPPER participants entered CLIPPER2 [ n  = 55 eoJIA, n  = 31 ERA, n  = 23 PsA; 99 (78%) on active treatment]; 84 (66%) completed 120 months' follow-up [32 (25%) on active treatment]. One malignancy (Hodgkin's disease in 18-year-old patient with eoJIA treated with methotrexate for 8 years) was reported; there were no cases of active tuberculosis or deaths. Numbers and incidence rates (events per 100 patient-years) of TEAEs (excluding infections/ISRs) decreased from 193 (173.81) in Year 1 to 9 (27.15) in Year 10; TE infections and serious infections also decreased. Over 45% of participants (n  = 127) achieved JIA ACR50 responses from Month 2 onwards; 42 (33%) and 34 (27%) participants achieved JADAS and ACR clinical remission, respectively. Conclusions Etanercept treatment up to 10 years was well tolerated, consistent with the known safety profile, with durable response in the participants still on active treatment. The benefit–risk assessment of etanercept in these JIA categories remains favourable. Trial registration ClinicalTrials.gov IDs: CLIPPER (NCT00962741); CLIPPER2 (NCT01421069) [ABSTRACT FROM AUTHOR]

Published
2024
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5. Application and performance of disease activity indices proposed for patients with systemic sclerosis in an international cohort of patients with juvenile systemic sclerosis

Author

Klotsche, Jens, primary, Torok, Kathryn S, additional, Kasapcopur, Ozgur, additional, Adrovic, Amra, additional, Terreri, Maria Teresa, additional, Sakamoto, Ana Paula, additional, Katsicas, Maria, additional, Sztajnbok, Flavio, additional, Marrani, Edoardo, additional, Sifuentes-Giraldo, Alberto, additional, Stanevicha, Valda, additional, Anton, Jordi, additional, Feldmann, Brian, additional, Kostik, Mikhail, additional, Nemcova, Dana, additional, Santos, Maria Jose, additional, Appenzeller, Simone, additional, Avcin, Tadej, additional, Battagliotti, Cristina, additional, Berntson, Lillemor, additional, Bica, Blanca, additional, Brunner, Jürgen, additional, Eleftheriou, Despina, additional, Harel, Liora, additional, Horneff, Gerd, additional, Kallinich, Tilmann, additional, Minden, Kirsten, additional, Nielsen, Susan, additional, Patwardhan, Anjali, additional, Helmus, Nicola, additional, and Foeldvari, Ivan, additional

Published
2023
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6. Etanercept treatment for extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis, or psoriatic arthritis: 6-year efficacy and safety data from an open-label trial

Author

Foeldvari, Ivan, Constantin, Tamàs, Vojinović, Jelena, Horneff, Gerd, Chasnyk, Vyacheslav, Dehoorne, Joke, Panaviene, Violeta, Sušić, Gordana, Stanevicha, Valda, Kobusinska, Katarzyna, Zuber, Zbigniew, Dobrzyniecka, Bogna, Nikishina, Irina, Bader-Meunier, Brigitte, Breda, Luciana, Doležalová, Pavla, Job-Deslandre, Chantal, Rumba-Rozenfelde, Ingrida, Wulffraat, Nico, Pedersen, Ronald D., Bukowski, Jack F., Vlahos, Bonnie, Martini, Alberto, Ruperto, Nicolino, and for the Paediatric Rheumatology International Trials Organisation (PRINTO)

Published
2019
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7. Gender differences in juvenile systemic sclerosis patients: Results from the international juvenile scleroderma inception cohort

Author

Foeldvari, Ivan, primary, Klotsche, Jens, additional, Kasapcopur, Ozgur, additional, Adrovic, Amra, additional, Terreri, Maria Teresa, additional, Sakamoto, Ana Paula, additional, Stanevicha, Valda, additional, Anton, Jordi, additional, Feldman, Brian M, additional, Sztajnbok, Flavio, additional, Khubchandani, Raju, additional, Alexeeva, Ekaterina, additional, Katsicas, Maria, additional, Sawhney, Sujata, additional, Smith, Vanessa, additional, Appenzeller, Simone, additional, Avcin, Tadej, additional, Kostik, Mikhail, additional, Lehman, Thomas, additional, Marrani, Edoardo, additional, Schonenberg-Meinema, Dieneke, additional, Sifuentes-Giraldo, Walter-Alberto, additional, Vasquez-Canizares, Natalia, additional, Janarthanan, Mahesh, additional, Moll, Monika, additional, Nemcova, Dana, additional, Patwardhan, Anjali, additional, Santos, Maria Jose, additional, Battagliotti, Cristina, additional, Berntson, Lillemor, additional, Bica, Blanca, additional, Brunner, Jürgen, additional, Cimaz, Rolando, additional, Costa-Reis, Patricia, additional, Eleftheriou, Despina, additional, Harel, Liora, additional, Horneff, Gerd, additional, Johnson, Sindhu R, additional, Kaiser, Daniela, additional, Kallinich, Tilmann, additional, Lazarevic, Dragana, additional, Minden, Kirsten, additional, Nielsen, Susan, additional, Nuruzzaman, Farzana, additional, Opsahl Hetlevik, Siri, additional, Uziel, Yosef, additional, Helmus, Nicola, additional, and Torok, Kathryn S, additional

Published
2022
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8. Diffuse juvenile systemic sclerosis patients show distinct organ involvement and have more severe disease in the largest jSSc cohort of the world. Results from the the juvenile scleroderma inception cohort

Author

Foeldvari, Ivan, Klotsche, Jens, Kasapcopur, Ozgur, Adrovic, Amra, Torok, Kathryn, Terreri, Maria Teresa, Sakamoto, Ana Paula, Feldman, Brian, Sztajnbok, Flavio, Stanevicha, Valda, Anton, Jordi, Johnson, Sindhu, Khubchandani, Raju, Alexeeva, Ekaterina, Katsicas, Maria, Sawhney, Sujata, Smith, Vanessa, Appenzeller, Simone, Avcin, Tadey, Kostik, Mikhail, Lehman, Thomas, Malcova, Hana, Marrani, Edoardo, Pain, Clare, Schonenberg, Dieneke, Sifuentes-Giraldo, W.-Alberto, Vasquez-Canizares, Natalia, Costa Reis, Patricia, Janarthanan, Mahesh, Moll, Monika, Nemcova, Dana, Patwardhan, Anjali, Santos, Maria Jose, Abu Al-Saoud, Sima, Battagliotti, Christina, Berntson, Lillemor, Bica, Blanca, Brunner, Juergen, Cimaz, Rolando, Eleftheriou, Despina, Harel, Liora, Horneff, Gerd, Kaiser, Daniela, Kallinich, Tilmann, Lazarevic, Dragana, Minden, Kirsten, Nuruzzaman, Farzana, Opsahl Hetlevik, Siri, Uziel, Yosef, and Helmus, Nicola

Subjects
Medicine and health
Abstract

Introduction: Juvenile systemic sclerosis (jSSc) is an orphan disease with a prevalence of 3 in 1,000,000 children [ref:1]. In adult patients there are significant differences between the clinical presentation of diffuse and limited subtypes [ref:2]. We reviewed clinical differences [for full text, please go to the a.m. URL]

Published
2022
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9. Juvenile systemic sclerosis treatment practices in an international cohort and comparison to recent SHARE consensus guidelines

Author

Foeldvari, Ivan, Klotsche, Jens, Kasapcopur, Ozgur, Adrovic, Amra, Torok, Kathryn, Terreri, Maria Teresa, Sakamoto, Ana Paula, Feldman, Brian, Anton, Jordi, Sztajnbok, Flavio, Stanevicha, Valda, Appenzeller, Simone, Avcin, Tadey, Johnson, Sindhu, Khubchandani, Raju, Kostik, Mikhail, Marrani, Edoardo, Sifuentes-Giraldo, W.-Alberto, Nemcova, Dana, Santos, Maria Jose, Schonenberg, Dieneke, Battagliotti, Christina, Berntson, Lillemor, Bica, Blanca, Brunner, Juergen, Cimaz, Rolando, Eleftheriou, Despina, Harel, Liora, Horneff, Gerd, Janarthanan, Mahesh, Kallinich, Tilmann, Lehman, Thomas, Moll, Monika, Nuruzzaman, Farzana, Patwardhan, Anjali, Smith, Vanessa, and Helmus, Nicola

Subjects
Medicine and health
Abstract

Introduction: Juvenile systemic scleroderma (jSSc) is an orphan disease with a prevalence of 3 in 1,000,000 children [ref:1]. Currently no medications are licensed for the treatment of jSSc. Due to its rarity, only recently have the first management and treatment guidelines been published, [for full text, please go to the a.m. URL]

Published
2022
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10. Clinical characteristics of juvenile onset systemic sclerosis patients from the juvenile scleroderma inception cohort compared to adult age juvenile-onset patients from EUSTAR. Are these differences suggesting risk for mortality?

Author

Foeldvari, Ivan, Klotsche, Jens, Carreira, Patricia E., Kasapcopur, Ozgur, Adrovic, Amra, Torok, Kathryn, Airò, Paolo, Iannone, Florenzo, Allanore, Yannick, Balbir-Gurman, Alexandra, Schmeiser, Tim, Sztajnbok, Flavio, Terreri, Maria Teresa, Stanevicha, Valda, Anton, Jordi, Feldman, Brian, Khubchandani, Raju, Alexeeva, Ekaterina, Johnson, Sindhu, Katsicas, Maria, Sawhney, Sujata, Smith, Vanessa, Appenzeller, Simone, Avcin, Tadey, Campochiaro, Corrado, De Vries-Bouwstra, Jeska, Kostik, Mikhail, Lehman, Thomas, Marrani, Edoardo, Schonenberg, Dieneke, Sifuentes-Giraldo, W.-Alberto, Vasquez-Canizares, Natalia, Janarthanan, Mahesh, Malcova, Hana, Moll, Monika, Nemcova, Dana, Patwardhan, Anjali, Santos, Maria Jose, Seskute, Goda, Truchetet, Marie-Elise, Veale, Douglas, Hoffmann-Vold, Anna-Maria, Gabrielli, Armando, and Distler, Oliver

Subjects
Medicine and health
Abstract

Introduction: Juvenile systemic sclerosis (jSSc) is an orphan autoimmune disease with a prevalence of 3 in 1,000,000 children. Information on long-term development of organ involvement and clinical characteristics of jSSc patients in adulthood are lacking. It was believed that patients in adult cohorts [for full text, please go to the a.m. URL]

Published
2022
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11. Patient and physician reported outcomes of juvenile systemic sclerosis patients significantly improve over 12 months observation period in the juvenile systemic scleroderma inception cohort

Author

Foeldvari, Ivan, Klotsche, Jens, Kasapcopur, Ozgur, Adrovic, Amra, Torok, Kathryn, Terreri, Maria Teresa, Feldman, Brian, Anton, Jordi, Katsicas, Maria, Stanevicha, Valda, Sztajnbok, Flavio, Appenzeller, Simone, Avcin, Tadey, Kostik, Mikhail, Marrani, Edoardo, Sifuentes-Giraldo, W.-Alberto, Johnson, Sindhu, Khubchandani, Raju, Nemcova, Dana, Santos, Maria Jose, Battagliotti, Christina, Berntson, Lillemor, Bica, Blanca, Brunner, Juergen, Cimaz, Rolando, Eleftheriou, Despina, Harel, Liora, Horneff, Gerd, Janarthanan, Mahesh, Kallinich, Tilmann, Minden, Kirsten, Moll, Monika, Nielsen, Susan, Patwardhan, Anjali, Schonenberg, Dieneke, Smith, Vanessa, and Helmus, Nicola

Subjects
Medicine and health
Abstract

Introduction: Juvenile systemic sclerosis (jSSc) is an orphan disease with a prevalence of 3 in 1,000,000 children [ref:1]. The Juvenile Systemic Scleroderma Inception cohort (jSScC) is the largest cohort of jSSc patients in the world. The jSScC collects longitudinal data prospectively in [for full text, please go to the a.m. URL]

Published
2022
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12. Underdetection of Interstitial Lung Disease in Juvenile Systemic Sclerosis

Author

Foeldvari, Ivan, Klotsche, Jens, Hinrichs, Bernd, Helmus, Nicola, Kasapcopur, Ozgur, Adrovic, Amra, Sztajnbok, Flavio, Terreri, Maria Teresa, Anton, Jordi, Smith, Vanessa, Katsicas, Maria, Kostik, Mikhail, Vasquez-Canizares, Natalia, Avcin, Tadej, Feldman, Brian, Janarthanan, Mahesh, Santos, Maria Jose, Sawhney, Sujata, Schonenberg-Meinema, Dieneke, Sifuentes-Giraldo, Walter-Alberto, Alexeeva, Ekaterina, Appenzeller, Simone, Battagliotti, Cristina, Berntson, Lillemor, Bica, Blanca, Costa-Reis, Patricia, Eleftheriou, Despina, Kallinich, Tilmann, Lehman, Thomas, Marrani, Edoardo, Minden, Kirsten, Nielsen, Susan, Nuruzzaman, Farzana, Patwardhan, Anjali, Khubchandani, Raju, Stanevicha, Valda, Uziel, Yosef, Torok, Kathryn S., Foeldvari, Ivan, Klotsche, Jens, Hinrichs, Bernd, Helmus, Nicola, Kasapcopur, Ozgur, Adrovic, Amra, Sztajnbok, Flavio, Terreri, Maria Teresa, Anton, Jordi, Smith, Vanessa, Katsicas, Maria, Kostik, Mikhail, Vasquez-Canizares, Natalia, Avcin, Tadej, Feldman, Brian, Janarthanan, Mahesh, Santos, Maria Jose, Sawhney, Sujata, Schonenberg-Meinema, Dieneke, Sifuentes-Giraldo, Walter-Alberto, Alexeeva, Ekaterina, Appenzeller, Simone, Battagliotti, Cristina, Berntson, Lillemor, Bica, Blanca, Costa-Reis, Patricia, Eleftheriou, Despina, Kallinich, Tilmann, Lehman, Thomas, Marrani, Edoardo, Minden, Kirsten, Nielsen, Susan, Nuruzzaman, Farzana, Patwardhan, Anjali, Khubchandani, Raju, Stanevicha, Valda, Uziel, Yosef, and Torok, Kathryn S.

Abstract

Objective. Utilizing data obtained from a prospective, international, juvenile systemic sclerosis (SSc) cohort, the present study was undertaken to determine if pulmonary screening with forced vital capacity (FVC) and diffusing capacity for carbon monoxide (DLco) is sufficient to assess the presence of interstitial lung disease (ILD) in comparison to high-resolution computed tomography (HRCT) in juvenile SSc. Methods. The juvenile SSc cohort database was queried for patients enrolled from January 2008 to January 2020 with recorded pulmonary function tests (PFTs) parameters and HRCT to determine the discriminatory properties of P FT parameters, FVC, and DLco in detecting ILD. Results. Eighty-six juvenile SSc patients had both computed tomography imaging and FVC values for direct comparison. Using findings on HRCT as the standard measure of ILD presence, the sensitivity of FVC in detecting ILD in juvenile SSc was only 40%, the specificity was 77%, and area under the curve (AUC) was 0.58. Fifty-eight juvenile SSc patients had both CT imaging and DLco values for comparison. The sensitivity of DLco in detecting ILD was 76%, the specificity was 70%, and AUC was 0.73. Conclusion. The performance of PFTs in juvenile SSc to detect underlying ILD was quite limited. Specifically, the FVC, which is one of the main clinical parameters in adult SSc to detect and monitor ILD, would miss -60% of children who had ILD changes on their accompanying HRCT. The DLco was more sensitive in detecting potential abnormalities on HRCT, but with less specificity than the FVC. These results support the use of HRCT in tandem with PFTs for the screening of ILD in juvenile SSc.

Published
2022
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13. sj-pdf-1-jso-10.1177_23971983221143244 – Supplemental material for Gender differences in juvenile systemic sclerosis patients: Results from the international juvenile scleroderma inception cohort

Author

Foeldvari, Ivan, Klotsche, Jens, Kasapcopur, Ozgur, Adrovic, Amra, Terreri, Maria Teresa, Sakamoto, Ana Paula, Stanevicha, Valda, Anton, Jordi, Feldman, Brian M, Sztajnbok, Flavio, Khubchandani, Raju, Alexeeva, Ekaterina, Katsicas, Maria, Sawhney, Sujata, Smith, Vanessa, Appenzeller, Simone, Avcin, Tadej, Kostik, Mikhail, Lehman, Thomas, Marrani, Edoardo, Schonenberg-Meinema, Dieneke, Sifuentes-Giraldo, Walter-Alberto, Vasquez-Canizares, Natalia, Janarthanan, Mahesh, Moll, Monika, Nemcova, Dana, Patwardhan, Anjali, Santos, Maria Jose, Battagliotti, Cristina, Berntson, Lillemor, Bica, Blanca, Brunner, Jürgen, Cimaz, Rolando, Costa-Reis, Patricia, Eleftheriou, Despina, Harel, Liora, Horneff, Gerd, Johnson, Sindhu R, Kaiser, Daniela, Kallinich, Tilmann, Lazarevic, Dragana, Minden, Kirsten, Nielsen, Susan, Nuruzzaman, Farzana, Opsahl Hetlevik, Siri, Uziel, Yosef, Helmus, Nicola, and Torok, Kathryn S

Subjects
110322 Rheumatology and Arthritis, FOS: Clinical medicine
Abstract

Supplemental material, sj-pdf-1-jso-10.1177_23971983221143244 for Gender differences in juvenile systemic sclerosis patients: Results from the international juvenile scleroderma inception cohort by Ivan Foeldvari, Jens Klotsche, Ozgur Kasapcopur, Amra Adrovic, Maria Teresa Terreri, Ana Paula Sakamoto, Valda Stanevicha, Jordi Anton, Brian M Feldman, Flavio Sztajnbok, Raju Khubchandani, Ekaterina Alexeeva, Maria Katsicas, Sujata Sawhney, Vanessa Smith, Simone Appenzeller, Tadej Avcin, Mikhail Kostik, Thomas Lehman, Edoardo Marrani, Dieneke Schonenberg-Meinema, Walter-Alberto Sifuentes-Giraldo, Natalia Vasquez-Canizares, Mahesh Janarthanan, Monika Moll, Dana Nemcova, Anjali Patwardhan, Maria Jose Santos, Cristina Battagliotti, Lillemor Berntson, Blanca Bica, Jürgen Brunner, Rolando Cimaz, Patricia Costa-Reis, Despina Eleftheriou, Liora Harel, Gerd Horneff, Sindhu R Johnson, Daniela Kaiser, Tilmann Kallinich, Dragana Lazarevic, Kirsten Minden, Susan Nielsen, Farzana Nuruzzaman, Siri Opsahl Hetlevik, Yosef Uziel, Nicola Helmus and Kathryn S Torok in Journal of Scleroderma and Related Disorders

Published
2022
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14. Gender differences in juvenile systemic sclerosis patients: Results from the international juvenile scleroderma inception cohort

Author

Foeldvari, Ivan, Klotsche, Jens, Kasapcopur, Ozgur, Adrovic, Amra, Terreri, Maria Teresa, Sakamoto, Ana Paula, Stanevicha, Valda, Anton, Jordi, Feldman, Brian M, Sztajnbok, Flavio, Khubchandani, Raju, Alexeeva, Ekaterina, Katsicas, Maria, Sawhney, Sujata, Smith, Vanessa, Appenzeller, Simone, Avcin, Tadej, Kostik, Mikhail, Lehman, Thomas, Marrani, Edoardo, Schonenberg-Meinema, Dieneke, Sifuentes-Giraldo, Walter-Alberto, Vasquez-Canizares, Natalia, Janarthanan, Mahesh, Moll, Monika, Nemcova, Dana, Patwardhan, Anjali, Santos, Maria Jose, Battagliotti, Cristina, Berntson, Lillemor, Bica, Blanca, Brunner, Jürgen, Cimaz, Rolando, Costa-Reis, Patricia, Eleftheriou, Despina, Harel, Liora, Horneff, Gerd, Johnson, Sindhu R, Kaiser, Daniela, Kallinich, Tilmann, Lazarevic, Dragana, Minden, Kirsten, Nielsen, Susan, Nuruzzaman, Farzana, Opsahl Hetlevik, Siri, Uziel, Yosef, Helmus, Nicola, and Torok, Kathryn S

Abstract

Objective: To compare organ involvement and disease severity between male and female patients with juvenile onset systemic sclerosis.Methods: Demographics, organ involvement, laboratory evaluation, patient-reported outcomes and physician assessment variables were compared between male and female juvenile onset systemic sclerosis patients enrolled in the prospective international juvenile systemic sclerosis cohort at their baseline visit and after 12 months.Results: One hundred and seventy-five juvenile onset systemic sclerosis patients were evaluated, 142 females and 33 males. Race, age of onset, disease duration, and disease subtypes (70% diffuse cutaneous) were similar between males and females. Active digital ulceration, very low body mass index, and tendon friction rubs were significantly more frequent in males. Physician global assessment of disease severity and digital ulcer activity was significantly higher in males. Composite pulmonary involvement was also more frequent in males, though not statistically significantly. After 12 months, they are the pattern of differences changed female patients had significantly more frequent pulmonary involvement.Conclusion: In this cohort, juvenile onset systemic sclerosis had a more severe course in males at baseline and but the pattern changed after 12 months. Some differences from adult findings persisted, there is no increased signal of pulmonary arterial hypertension or heart failure in male pediatric patients. While monitoring protocols of organ involvement in juvenile onset systemic sclerosis need to be identical for males and females.

Published
2023
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15. Underdetection of Interstitial Lung Disease in Juvenile Systemic Sclerosis

Author

Foeldvari, Ivan, primary, Klotsche, Jens, additional, Hinrichs, Bernd, additional, Helmus, Nicola, additional, Kasapcopur, Ozgur, additional, Adrovic, Amra, additional, Sztajnbok, Flavio, additional, Terreri, Maria Teresa, additional, Anton, Jordi, additional, Smith, Vanessa, additional, Katsicas, Maria, additional, Kostik, Mikhail, additional, Vasquez‐Canizares, Natalia, additional, Avcin, Tadej, additional, Feldman, Brian, additional, Janarthanan, Mahesh, additional, Santos, Maria Jose, additional, Sawhney, Sujata, additional, Schonenberg‐Meinema, Dieneke, additional, Sifuentes‐Giraldo, Walter‐Alberto, additional, Alexeeva, Ekaterina, additional, Appenzeller, Simone, additional, Battagliotti, Cristina, additional, Berntson, Lillemor, additional, Bica, Blanca, additional, Costa‐Reis, Patrícia, additional, Eleftheriou, Despina, additional, Kallinich, Tilmann, additional, Lehman, Thomas, additional, Marrani, Edoardo, additional, Minden, Kirsten, additional, Nielsen, Susan, additional, Nuruzzaman, Farzana, additional, Patwardhan, Anjali, additional, Khubchandani, Raju, additional, Stanevicha, Valda, additional, Uziel, Yosef, additional, and Torok, Kathryn S., additional

Published
2022
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16. 2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative

Author

Ravelli, Angelo, Minoia, Francesca, Davì, Sergio, Horne, AnnaCarin, Bovis, Francesca, Pistorio, Angela, Aricò, Maurizio, Avcin, Tadej, Behrens, Edward M., De Benedetti, Fabrizio, Filipovic, Lisa, Grom, Alexei A., Henter, Jan-Inge, Ilowite, Norman T., Jordan, Michael B., Khubchandani, Raju, Kitoh, Toshiyuki, Lehmberg, Kai, Lovell, Daniel J., Miettunen, Paivi, Nichols, Kim E., Ozen, Seza, Schmid, Jana Pachlopnik, Ramanan, Athimalaipet V., Russo, Ricardo, Schneider, Rayfel, Sterba, Gary, Uziel, Yosef, Wallace, Carol, Wouters, Carine, Wulffraat, Nico, Demirkaya, Erkan, Brunner, Hermine I., Martini, Alberto, Ruperto, Nicolino, Cron, Randy Q., Abinun, Mario, Aggarwal, Amita, Akikusa, Jonathan, Al-Mayouf, Sulaiman M., Alessio, Maria, Anton, Jordi, Apaz, Maria Teresa, Astigarraga, Itziar, Ayaz, Nuray A., Barone, Patrizia, Bica, Blanca, Bolt, Isabel, Breda, Luciana, Chasnyk, Vyacheslav, Cimaz, Rolando, Corona, Fabrizia, Cuttica, Ruben, DʼAngelo, Gianfranco, Davidsone, Zane, De Cunto, Carmen, De Inocencio, Jaime, Eisenstein, Eli, Enciso, Sandra, Espada, Graciela, Fischbach, Michel, Frosch, Michael, Gallizzi, Romina, Gamir, Maria Luz, Gao, Yi-Jin, Griffin, Thomas, Hashad, Soad, Hennon, Teresa, Horneff, Gerd, Huasong, Zeng, Huber, Adam, Ilowite, Norman, Insalaco, Antonella, Ioseliani, Maka, Jelusic-Drazic, Marijia, Jeng, Michael, Kapovic, Agneza, Kasapcopur, Ozgur, Kone-Paut, Isabelle, de Oliveira, Sheila Knupp Feitosa, Lattanzi, Bianca, Lepore, Loredana, Li, Caifeng, Lipton, Jeffrey M., Magni-Manzoni, Silvia, Maritsi, Despoina, McCurdy, Deborah, Merino, Rosa, Mulaosmanovic, Velma, Nielsen, Susan, Pal, Priyankar, Prahalad, Sampath, Rigante, Donato, Rumba-Rozenfelde, Ingrida, Magalhaes, Claudia Saad, Sanner, Helga, Sawhney, Sujata, Sewairi, Wafaa M., Shakoory, Bita, Shenoi, Susan, Clovis, Artur Silva, Stanevicha, Valda, Stine, Kimo C., Susic, Gordana, Sztajnbok, Flavio, Takei, Syuji, Tezer, Hasan, Trauzeddel, Ralf, Tsitsami, Elena, Unsal, Erbil, Vougiouka, Olga, Weaver, Lehn K., Weiss, Jennifer, Weitzman, Sheila, and Zletni, Mabruka

Published
2016
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17. Development and Initial Validation of the Macrophage Activation Syndrome/Primary Hemophagocytic Lymphohistiocytosis Score, a Diagnostic Tool that Differentiates Primary Hemophagocytic Lymphohistiocytosis from Macrophage Activation Syndrome

Author

Minoia, Francesca, Bovis, Francesca, Davì, Sergio, Insalaco, Antonella, Lehmberg, Kai, Shenoi, Susan, Weitzman, Sheila, Espada, Graciela, Gao, Yi-Jin, Anton, Jordi, Kitoh, Toshiyuki, Kasapcopur, Ozgur, Sanner, Helga, Merino, Rosa, Astigarraga, Itziar, Alessio, Maria, Jeng, Michael, Chasnyk, Vyacheslav, Nichols, Kim E., Huasong, Zeng, Li, Caifeng, Micalizzi, Concetta, Ruperto, Nicolino, Martini, Alberto, Cron, Randy Q., Ravelli, Angelo, Horne, AnnaCarin, Abinun, Mario, Aggarwal, Amita, Akikusa, Jonathan, Al-Mayouf, Sulaiman, Apaz, Maria Teresa, Avcin, Tadej, Ayaz, Nuray Aktay, Barone, Patrizia, Bica, Bianca, Bolt, Isabel, Breda, Luciana, Cimaz, Rolando, Corona, Fabrizia, Cuttica, Ruben, Davidsone, Zane, De Cunto, Carmen, De Inocencio, Jaime, Demirkaya, Erkan, Eisenstein, Eli M., Enciso, Sandra, Fischbach, Michel, Frosch, Michael, Gallizzi, Romina, Gamir, Maria Luz, Griffin, Thomas, Grom, Alexei, Hashad, Soad, Hennon, Teresa, Henter, Jan-Inge, Horne, AnnaCarin, Horneff, Gerd, Huber, Adam, Ilowite, Norman, Ioseliani, Maka, Kapović, Agneza Marija, Khubchandani, Raju, Koné-Paut, Isabelle, de Oliveira, Sheila Knupp Feitosa, Lattanzi, Bianca, Lepore, Loredana, Lipton, Jeffrey M., Magni-Manzoni, Silvia, Maritsi, Despoina, McCurdy, Deborah, Miettunen, Paivi, Mulaosmanovic, Velma, Nielsen, Susan, Ozen, Seza, Pal, Priyankar, Prahalad, Sampath, Rigante, Donato, Rumba-Rozenfelde, Ingrida, Ruperto, Nicolino, Russo, Ricardo, Magalhães, Claudia Saad, Sewairi, Wafaa Mohamed Saad, Silva, Clovis Artur, Stanevicha, Valda, Sterba, Gary, Stine, Kimo C., Susic, Gordana, Sztajnbok, Flavio, Takei, Syuji, Trauzeddel, Ralf, Tsitsami, Elena, Unsal, Erbil, Uziel, Yosef, Vougiouka, Olga, Wallace, Carol A., Weaver, Lehn, Weiss, Jennifer E., Wouters, Carine, Wulffraat, Nico, Zletni, Mabruka, Arico, Maurizio, Egeler, Maarten R., Filipovich, Alexandra H., Gadner, Helmut, Imashuku, Shinsaku, Janka, Gritta, Ladisch, Stephan, McClain, Ken L., and Webb, David

Published
2017
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18. Methotrexate withdrawal at 6 vs 12 months in juvenile idiopathic arthritis in remission

Author

Foell, Dirk, Wulfraat, Nico, Wedderburn, Lucy R., Wittkowski, Helmut, Frosch, Michael, Gerb, Joachim, Stanevicha, Valda, Mihaylova, Dimitrina, Ferriani, Virginia, Tsakalidou, Florence Kanakoudi, Foeldvari, Ivan, Cuttica, Ruben, Gonzalez, Benito, Ravelli, Angelo, Khubchandani, Raju, Oliviera, Sheila, Armbrust, Wineke, Garay, Stella, Vojinovic, Jelena, Norambuena, Ximena, Gamir, Maria Luz, Garcia-Consuegra, Julia, Lepore, Loredana, Susie, Gordana, Corona, Fabrizia, Dolezalova, Pavla, Pistorio, Angela, Martini, Alberto, Ruperto, Nicolino, and Roth, Johannes

Subjects
Methotrexate -- Usage, Methotrexate -- Health aspects, Juvenile arthritis -- Patient outcomes, Juvenile arthritis -- Drug therapy, Diseases -- Relapse, Diseases -- Evaluation
Abstract

The study aims to evaluate and compare the efficacy of methotrexate withdrawal at 6 months as against 12 months in juvenile idiopathic arthritis (JIA) in remission. The results indicate that in case of such patients, there was not much difference in reduction in relapse rate in either of the cases.

Published
2010

19. Performance of Current Guidelines for Diagnosis of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis

Author

Davì, Sergio, Minoia, Francesca, Pistorio, Angela, Horne, AnnaCarin, Consolaro, Alessandro, Rosina, Silvia, Bovis, Francesca, Cimaz, Rolando, Gamir, Maria Luz, Ilowite, Norman T., Kone-Paut, Isabelle, Feitosa de Oliveira, Sheila Knupp, McCurdy, Deborah, Silva, Clovis Artur, Sztajnbok, Flavio, Tsitsami, Elena, Unsal, Erbil, Weiss, Jennifer E., Wulffraat, Nico, Abinun, Mario, Aggarwal, Amita, Apaz, Maria Teresa, Astigarraga, Itziar, Corona, Fabrizia, Cuttica, Ruben, DʼAngelo, Gianfranco, Eisenstein, Eli M., Hashad, Soad, Lepore, Loredana, Mulaosmanovic, Velma, Nielsen, Susan, Prahalad, Sampath, Rigante, Donato, Stanevicha, Valda, Sterba, Gary, Susic, Gordana, Takei, Syuji, Trauzeddel, Ralf, Zletni, Mabruka, Ruperto, Nicolino, Martini, Alberto, Cron, Randy Q., and Ravelli, Angelo

Published
2014
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20. Growth and Puberty in Juvenile Dermatomyositis: A Longitudinal Cohort Study

Author

Nordal, Ellen Pistorio, Angela Rygg, Marite Giancane, Gabriella Maghnie, Mohamad Di Iorgi, Natascia Flemming, Kristina Hofer, Michael Melo-Gomes, Jose A. Bica, Blanca E. R. G. Brunner, Jurgen Dannecker, Guenther Gerloni, Valeria and Harjacek, Miroslav Huppertz, Hans-Iko Pratsidou-Gertsi, Polyxeni Nielsen, Susan Stanevicha, Valda Ten Cate, Rebecca and Vougiouka, Olga Pastore, Serena Simonini, Gabriele and Ravelli, Angelo Martini, Alberto Ruperto, Nicolino Paediat Rheumatology Int Trials

Abstract

Objective To study growth and puberty in a multinational longitudinal prospective cohort of children with juvenile dermatomyositis (DM). Methods Children from 31 countries who were ages DM in active phase were studied, and analyses of height, weight, and pubertal development were conducted in those who had follow-up visits during a 2-year period and for whom anthropometric data was available. Results A total of 196 of 275 children (71%) were included. We found a significant reduction in parent-adjusted height Z score over time in female patients (P < 0.0001) and male patients (P = 0.001), but with catch-up growth at the final study visit. Median body mass index Z score peaked at 6 months (P < 0.0001) and was still significantly above baseline at the final study visit, which was at a median of 26 months after baseline (P = 0.007), with no difference between sexes. Female patients with a disease duration >= 12 months after onset had significantly lower parent-adjusted height Z score (P = 0.002) and no 2-year catch-up growth. At the final study visit, growth failure was seen in 20 of 97 female patients (21%) and in 11 of 73 male patients (15%). Height deflection ( increment height Z score less than -0.25/year) was observed in 29 of 116 female patients (25%) and 25 of 80 male patients (31.3%). Delayed puberty was seen in 20 of 55 female patients (36.4%) and in 11 of 31 male patients (35.5%). Children in early pubertal stage at baseline had the highest risk of growth failure. Conclusion Juvenile DM in the active phase and/or its treatment has a significant impact on growth and puberty in affected children. Children with recent onset of puberty or previous growth failure have the highest risk of delayed pubertal development and further growth retardation.

Published
2020

21. Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: Analysis by the Pharmachild Safety Adjudication Committee

Author

Immuno/reuma patientenzorg, Child Health, Infectieziekten patientenzorg, Infection & Immunity, Cluster B, Immuno/reuma onderzoek 1 (Vastert), Immunologie/Reumatologie, Regenerative Medicine and Stem Cells, Onderzoek, Giancane, Gabriella, Swart, Joost F., Castagnola, Elio, Groll, Andreas H., Horneff, Gerd, Huppertz, Hans Iko, Lovell, Daniel J., Wolfs, Tom, Herlin, Troels, Dolezalova, Pavla, Sanner, Helga, Susic, Gordana, Sztajnbok, Flavio, Maritsi, Despoina, Constantin, Tamas, Vargova, Veronika, Sawhney, Sujata, Rygg, Marite, Oliveira, Sheila K., Cattalini, Marco, Bovis, Francesca, Bagnasco, Francesca, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, Ruperto, Nicolino, Cuttica, Ruben, Garay, Stella Maris, Brunner, Jurgen, Emminger, Wolfgang, Appenzeller, Simone, Len, Claudio, Saad Magalhaes, Claudia, Telcharova-Mihaylovska, Albena, Harjacek, Miroslav, Jelusic, Marija, Estmann, Anne, Nielsen, Susan, Herrera Mora, Cristina, Gervais, Elisabeth, Koné-Paut, Isabelle, Quartier, Pierre, Foeldvari, Ivan, Lutz, Thomas, Minden, Kirsten, Tzaribachev, Nikolay, Trachana, Maria, Tsitsami, Elena, Vougiouka, Olga, Orban, Ilonka, Harel, Liora, Hashkes, Philip, Uziel, Yosef, Cimaz, Rolando, Civino, Adele, Consolini, Rita, D'Angelo, Gianfranco, De Benedetti, Fabrizio, Filocamo, Giovanni, Fueri, Elena, Gallizzi, Romina, Maggio, Maria Cristina, Magnolia, Maria Greca, Miniaci, Angela, Montin, Davide, Olivieri, Alma Nunzia, Pastore, Serena, Rigante, Donato, Zulian, Francesco, Rumba-Rozenfelde, Ingrida, Stanevicha, Valda, Panaviene, Violeta, Rodriguez Lozano, Ana Luisa, Rubio-Perez, Nadina, Vega Cornejo, Gabriel, Hoppenreijs, Esther, Kamphuis, Sylvia, Flato, Berit, Nordal, Ellen Berit, Abdwani, Reem, Miraval, Tatiana, Paz Gastanaga, Maria Eliana, Smolewska, Elzbieta, Ailioaie, Constantin, Cochino, Alexis Virgil, Laday, Matilda, Lazar, Calin, Alexeeva, Ekaterina, Chasnyk, Vyacheslav, Keltsev, Vladimir, Suwairi, Wafaa Mohammed Saad, Vijatov-Djuric, Gordana, Vojinovic, Jelena, Arkachaisri, Thaschawee, Koskova, Elena, Avcin, Tadej, Ally, Mahmood, Van Rensburg, Christa Janse, Louw, Ingrid, Lopez, Jordi Anton, Boteanu, Alina Lucica, Calvo Penades, Inmaculada, De Inocencio, Jaime, Mesa-Del-Castillo, Pablo, Moreno, Estefania, Remesal, Agustin, Hofer, Michael, Gok, Faysal, Ozen, Seza, Ramanan, Athimalaipet, Pallotti, Chiara, Villa, Luca, Immuno/reuma patientenzorg, Child Health, Infectieziekten patientenzorg, Infection & Immunity, Cluster B, Immuno/reuma onderzoek 1 (Vastert), Immunologie/Reumatologie, Regenerative Medicine and Stem Cells, Onderzoek, Giancane, Gabriella, Swart, Joost F., Castagnola, Elio, Groll, Andreas H., Horneff, Gerd, Huppertz, Hans Iko, Lovell, Daniel J., Wolfs, Tom, Herlin, Troels, Dolezalova, Pavla, Sanner, Helga, Susic, Gordana, Sztajnbok, Flavio, Maritsi, Despoina, Constantin, Tamas, Vargova, Veronika, Sawhney, Sujata, Rygg, Marite, Oliveira, Sheila K., Cattalini, Marco, Bovis, Francesca, Bagnasco, Francesca, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, Ruperto, Nicolino, Cuttica, Ruben, Garay, Stella Maris, Brunner, Jurgen, Emminger, Wolfgang, Appenzeller, Simone, Len, Claudio, Saad Magalhaes, Claudia, Telcharova-Mihaylovska, Albena, Harjacek, Miroslav, Jelusic, Marija, Estmann, Anne, Nielsen, Susan, Herrera Mora, Cristina, Gervais, Elisabeth, Koné-Paut, Isabelle, Quartier, Pierre, Foeldvari, Ivan, Lutz, Thomas, Minden, Kirsten, Tzaribachev, Nikolay, Trachana, Maria, Tsitsami, Elena, Vougiouka, Olga, Orban, Ilonka, Harel, Liora, Hashkes, Philip, Uziel, Yosef, Cimaz, Rolando, Civino, Adele, Consolini, Rita, D'Angelo, Gianfranco, De Benedetti, Fabrizio, Filocamo, Giovanni, Fueri, Elena, Gallizzi, Romina, Maggio, Maria Cristina, Magnolia, Maria Greca, Miniaci, Angela, Montin, Davide, Olivieri, Alma Nunzia, Pastore, Serena, Rigante, Donato, Zulian, Francesco, Rumba-Rozenfelde, Ingrida, Stanevicha, Valda, Panaviene, Violeta, Rodriguez Lozano, Ana Luisa, Rubio-Perez, Nadina, Vega Cornejo, Gabriel, Hoppenreijs, Esther, Kamphuis, Sylvia, Flato, Berit, Nordal, Ellen Berit, Abdwani, Reem, Miraval, Tatiana, Paz Gastanaga, Maria Eliana, Smolewska, Elzbieta, Ailioaie, Constantin, Cochino, Alexis Virgil, Laday, Matilda, Lazar, Calin, Alexeeva, Ekaterina, Chasnyk, Vyacheslav, Keltsev, Vladimir, Suwairi, Wafaa Mohammed Saad, Vijatov-Djuric, Gordana, Vojinovic, Jelena, Arkachaisri, Thaschawee, Koskova, Elena, Avcin, Tadej, Ally, Mahmood, Van Rensburg, Christa Janse, Louw, Ingrid, Lopez, Jordi Anton, Boteanu, Alina Lucica, Calvo Penades, Inmaculada, De Inocencio, Jaime, Mesa-Del-Castillo, Pablo, Moreno, Estefania, Remesal, Agustin, Hofer, Michael, Gok, Faysal, Ozen, Seza, Ramanan, Athimalaipet, Pallotti, Chiara, and Villa, Luca

Published
2020

23. Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative study

Author

Gerss, Joachim, Roth, Johannes, Holzinger, Dirk, Ruperto, Nicolino, Wittkowski, Helmut, Frosch, Michael, Wulffraat, Nico, Wedderburn, Lucy, Stanevicha, Valda, Mihaylova, Dimitrina, Harjacek, Miroslav, Len, Claudio, Toppino, Claudia, Masi, Massimo, Minden, Kirsten, Saurenmann, Traudel, Uziel, Yosef, Vesely, Richard, Apaz, Maria Teresa, Kuester, Rolf-Michael, Elorduy, Maria Jesus Rua, Burgos-Vargas, Ruben, Ioseliani, Maka, Magni-Manzoni, Silvia, Unsal, Erbil, Anton, Jordi, Balogh, Zsolt, Hagelberg, Stefan, Mazur-Zielinska, Henryka, Tauber, Tsivia, Martini, Alberto, and Foell, Dirk

Published
2012
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25. EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part I: Overall methodology and clinical characterisation

Author

Ruperto, Nicolino, Ozen, Seza, Pistorio, Angela, Dolezalova, Pavla, Brogan, Paul, Cabral, David A, Cuttica, Ruben, Khubchandani, Raju, Lovell, Daniel J, OʼNeil, Kathleen M, Quartier, Pierre, Ravelli, Angelo, Iusan, Silvia M, Filocamo, Giovanni, Magalhães, Claudia Saad, Unsal, Erbil, Oliveira, Sheila, Bracaglia, Claudia, Bagga, Arvind, Stanevicha, Valda, Manzoni, Silvia Magni, Pratsidou, Polyxeni, Lepore, Loredana, Espada, Graciela, Paut, Isabelle Kone, Zulian, Francesco, Barone, Patrizia, Bircan, Zelal, Maldonado, Maria del, Russo, Ricardo, Vilca, Iris, Tullus, Kjell, Cimaz, Rolando, Horneff, Gerd, Anton, Jordi, Garay, Stella, Nielsen, Susan, Barbano, Giancarlo, and Martini, Alberto

Published
2010
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26. EULAR/PRINTO/PRES criteria for Henoch-Schonlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part 1: overall methodology and clinical characterisation

Author

Ruperto, Nicolino, Ozen, Seza, Pistorio, Angela, Dolezalova, Pavla, Brogan, Paul, Cabral, David A., Cuttica, Ruben, Khubchandani, Raju, Lovell, Daniel J., O'Neil, Kathleen, Quartier, Pierre, Ravelli, Angelo, Iusan, Silvia M., Filocamo, Gioivanni, Magalhaes, Claudia Saad, Unsal, Erbil, Oliveira, Sheila, Bracaglia, Claudia, Bagga, Arvind, Stanevicha, Valda, Manzoni, Silvia Magni, Pratsidou, Polyxeni, Lepore, Loredana, Espada, Graciela, Paut, Isabelle Kone, Zulian, Francesco, Barone, Patrizia, Bircan, Zelal, del Rocio Maldonado, Maria, Russo, Ricardo, Vilca, Iris, Tullus, Kjell, Cimaz, Rolando, Horneff, Gerd, Anton, Jordi, Garay, Stella, Nielsen, Susan, Barbano, Giancarlo, and Martini, Alberto

Subjects
Schonlein-Henoch purpura -- Diagnosis, Schonlein-Henoch purpura -- Identification and classification, Schonlein-Henoch purpura -- Research, Wegener's granulomatosis -- Diagnosis, Wegener's granulomatosis -- Identification and classification, Wegener's granulomatosis -- Research, Takayasu's arteritis -- Diagnosis, Takayasu's arteritis -- Identification and classification, Takayasu's arteritis -- Research, Children -- Diseases, Children -- Diagnosis, Children -- Identification and classification, Children -- Research, Health
Published
2010

27. Do Raynaud phenomenon negative juvenile systemic scleroderma patients have a different pattern of organ involvement as Raynaud phenomenon positive patients?

Author

Foeldvari, Ivan, Klotsche, Jens, Kasapcopur, Ozgur, Adrovic, Amra, Torok, Kathryn, Stanevicha, Valda, Terreri, M. T., Alexeeva, Ekaterina, Katsicas, Maria, Smith, Vanessa, Sztajnbok, Flavio, Avcin, Tadey, Cimaz, Rolando, Anton, Jordi, Kostik, Mikhail, Lehman, Thomas, Sifuentes-Giraldo, W. Alberto, Appenzeller, Simone, Janarthanan, Mahesh, Moll, Monika, Nemcova, Dana, Jose Santos, Maria, Battagliotti, Cristina, Berntson, Lillemor, Brunner, Jürgen, Costa Reis, Patrícia, Eleftheriou, Despina, Harel, Liora, Kallinich, Tilmann, Minden, Kirsten, Nielsen, Susan, Uziel, Yosef, Stevens, Ann, Pilkington, Clarissa, and Helmus, Nicola

Subjects
integumentary system, ddc: 610, 610 Medical sciences, Medicine, skin and connective tissue diseases
Abstract

Background: Juvenile systemic scleroderma (jSSc) is an orphan disease, with an estimated prevalence of 3 per 1000 000 children. Most jSSc patients primarily present with Raynaud phenomenon (RP). We investigated in our patient of the juvenile scleroderma inception cohort, how fare patients with (RP+)[for full text, please go to the a.m. URL], 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2019
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28. Additional file 1: of Etanercept treatment for extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis, or psoriatic arthritis: 6-year efficacy and safety data from an open-label trial

Author

Foeldvari, Ivan, Tamàs Constantin, Vojinović, Jelena, Horneff, Gerd, Chasnyk, Vyacheslav, Dehoorne, Joke, Panaviene, Violeta, Sušić, Gordana, Stanevicha, Valda, Kobusinska, Katarzyna, Zuber, Zbigniew, Bogna Dobrzyniecka, Nikishina, Irina, Bader-Meunier, Brigitte, Breda, Luciana, Doležalová, Pavla, Job-Deslandre, Chantal, Rumba-Rozenfelde, Ingrida, Wulffraat, Nico, Pedersen, Ronald, Bukowski, Jack, Vlahos, Bonnie, Martini, Alberto, and Ruperto, Nicolino

Abstract

Table S1. Summary of missing data imputation methods for the responder analysis. Table S2. Disease activity and patient-reported outcomes (observed cases). Table S3. Outcomes specific for enthesitis-related arthritis and psoriatic arthritis (observed cases). Table S4. The most frequent TEAEs, excluding infections and injection site reactions (> 5% in any JIA subtype, by System Organ Class). Figure S1. ACR30–100 and JIA inactive disease response rates (OC vs NRI). Additional Tables (A1 to A4) and Figure A1 related to missing data imputation based on patients’ enrolment status, trial period at cut-off date, and reasons for permanent discontinuation. (DOCX 224 kb)

Published
2019
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29. Etanercept treatment for extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis, or psoriatic arthritis: 6-year efficacy and safety data from an open-label trial

Author

Immunologie/Reumatologie, Cluster B, Immuno/reuma onderzoek 1 (Vastert), Onderzoek, Child Health, Regenerative Medicine and Stem Cells, Infection & Immunity, Foeldvari, Ivan, Constantin, Tamàs, Vojinović, Jelena, Horneff, Gerd, Chasnyk, Vyacheslav, Dehoorne, Joke, Panaviene, Violeta, Sušić, Gordana, Stanevicha, Valda, Kobusinska, Katarzyna, Zuber, Zbigniew, Dobrzyniecka, Bogna, Nikishina, Irina, Bader-Meunier, Brigitte, Breda, Luciana, Doležalová, Pavla, Job-Deslandre, Chantal, Rumba-Rozenfelde, Ingrida, Wulffraat, Nico, Pedersen, Ronald D., Bukowski, Jack F., Vlahos, Bonnie, Martini, Alberto, Ruperto, Nicolino, Immunologie/Reumatologie, Cluster B, Immuno/reuma onderzoek 1 (Vastert), Onderzoek, Child Health, Regenerative Medicine and Stem Cells, Infection & Immunity, Foeldvari, Ivan, Constantin, Tamàs, Vojinović, Jelena, Horneff, Gerd, Chasnyk, Vyacheslav, Dehoorne, Joke, Panaviene, Violeta, Sušić, Gordana, Stanevicha, Valda, Kobusinska, Katarzyna, Zuber, Zbigniew, Dobrzyniecka, Bogna, Nikishina, Irina, Bader-Meunier, Brigitte, Breda, Luciana, Doležalová, Pavla, Job-Deslandre, Chantal, Rumba-Rozenfelde, Ingrida, Wulffraat, Nico, Pedersen, Ronald D., Bukowski, Jack F., Vlahos, Bonnie, Martini, Alberto, and Ruperto, Nicolino

Published
2019

30. AB0967 IS THERE A DIFFERENCE IN PRESENTATION OF FEMALE AND MALE PATIENTS WITH JUVENILE SYSTEMIC SCLERODERMA. AN UPDATE FROM THE JUVENILE SYSTEMIC SCLERODERMA INCEPTION COHORT. WWW.JUVENILE-SCLERODERMA.COM

Author

Foeldvari, Ivan, primary, Klotsche, Jens, additional, Kasapcopur, Ozgur, additional, Adrovic, Amra, additional, Torok, Kathryn, additional, Stanevicha, Valda, additional, Sztajnbok, Flávio R., additional, Sakamoto, Ana Paula, additional, Alexeeva, Ekaterina, additional, Anton, Jordi, additional, Katsikas, Maria, additional, Smith, Vanessa, additional, Avcin, Tadej, additional, Cimaz, Rolando, additional, Kostik, Mikhail, additional, Lehman, Thomas, additional, Sifuentes-Giraldo, Walter Alberto, additional, Appenzeller, Simone, additional, Janarthanan, Mahesh, additional, Moll, Monika, additional, Nemcova, Dana, additional, Santos, Maria Jose, additional, Nassar, Amara, additional, Battagliotti, Cristina, additional, Berntson, Lillemor, additional, Bica, Blanca, additional, Brunner, Juergen, additional, Reis, Patricia Costa, additional, Eleftheriou, Despina, additional, Harel, Liora, additional, Horneff, Gerd, additional, Kallinich, Tilmann, additional, Lazarevic, Dragana, additional, Minden, Kirsten, additional, Nielsen, Susan, additional, Nuruzzaman, Farzana, additional, Patwardhan, Anjali, additional, Uziel, Yosef, additional, and Helmus, Nicola, additional

Published
2019
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31. SAT0479 UPDATE FROM THE JUVENILE SCLERODERMA INCEPTION COHORT. WWW.JUVENILE-SCLERODERMA.COM

Author

Foeldvari, Ivan, primary, Klotsche, Jens, additional, Kasapcopur, Ozgur, additional, Adrovic, Amra, additional, Torok, Kathryn, additional, Stanevicha, Valda, additional, Sztajnbok, Flávio R., additional, Tererri, Maria T., additional, Alexeeva, Ekaterina, additional, Anton, Jordi, additional, Katsikas, Maria, additional, Smith, Vanessa, additional, Avcin, Tadej, additional, Cimaz, Rolando, additional, Kostik, Mikhail, additional, Lehman, Thomas, additional, Sifuentes-Giraldo, Walter Alberto, additional, Appenzeller, Simone, additional, Janarthanan, Mahesh, additional, Moll, Monika, additional, Nemcova, Dana, additional, Santos, Maria Jose, additional, Schonenberg, Dieneke, additional, Battagliotti, Cristina, additional, Berntson, Lillemor, additional, Bica, Blanca, additional, Brunner, Juergen, additional, Reis, Patricia Costa, additional, Eleftheriou, Despina, additional, Harel, Liora, additional, Horneff, Gerd, additional, Kallinich, Tilmann, additional, Lazarevic, Dragana, additional, Minden, Kirsten, additional, Nielsen, Susan, additional, Nuruzzaman, Farzana, additional, Patwardhan, Anjali, additional, Uziel, Yosef, additional, and Helmus, Nicola, additional

Published
2019
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32. HLA B27 allele types in homogeneous groups of juvenile idiopathic arthritis patients in Latvia

Author

Guseinova Dinara, Lazareva Arina, Sochnevs Arturs, Zavadska Dace, Eglite Jelena, Stanevicha Valda, Shantere Ruta, and Gardovska Dace

Subjects
Pediatrics, RJ1-570, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Juvenile idiopathic arthritis (JIA) is a heterogeneous condition and therapeutic strategies vary in different JIA types. The routinely accepted practice to start with Sulphasalazine (SS) as the first line treatment in patients with HLA B27 positive JIA proves to be ineffective in a large proportion of children. Objective to investigate HLA B27 positive JIA patients clinical characteristics, determined HLA B27 allele types and their connection with antirheumatic treatment in homogenous patient groups. Materials and methods 56 patients diagnosed with JIA and observed over the period 2006 to 2009 included in the study. HLAB27 allele types were determined using PCR method. Results In HLA B27 positive JIA patients mean disease onset was 12.34 ± 3.3 years. Most common (44%) JIA type was enthesitis related arthritis. Positive response to the treatment with SS was found in 32% of patients, Methotrexate (MTX) - in 43%, combined treatment - SS with MTX was effective in 12.5%. 12.5% of patients required combination MTX with Enbrel. Eight HLA B27 allele types were found in JIA patients in Latvia: *2702, *2703, *2704, *2705, *2710, *2715, *2717, *2728. The most common was *2705 - in 55% of cases. Among all the patients enthesitis related arthritis most commonly occurred in patients with HLAB*2705 allele (OR = 2.01, p < 0.02), oligoarthritis in patients with *2710 allele (OR = 3.0, p < 0.04) and polyarthritis with *2717 allele (OR = 3.0, p < 0.05). In patients with *2705 allele effective treatment was MTX (OR = 1.13, p < 0.03) and MTX with SS (OR = 2.02, p < 0.05), but in patients having *2703 allele - MTX with Enbrel (OR = 2.94, p < 0.02). Conclusions There are 8 different HLA B27 alleles in JIA patients in Latvia and the most common is *2705, but in order to assert them to be disease associated alleles, more extensive studies are needed, including control group of HLA B27 positive healthy individuals. Standard treatment approach with SS proves to be unsatisfactory in the majority of JIA patients. To improve children's quality of life achieving rapid disease control, the first line treatment in HLA B27 positive patients should be MTX. In order to start with the most appropriate drug it is necessary to determine HLAB 27 type at the onset of disease.

Published
2010
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34. Update from the Juvenile Scleroderma Inception Cohort

Author

Foeldvari, Ivan, Klotsche, Jens, Kasapcopur, Ozgur, Adrovic, Amra, Torok, Kathryn S., Stanevicha, Valda, Sztajnbok, Flavio, Terreri, Maria Teresa, Alexeeva, Ekaterina, Anton, Jordi, Katsicas, Maria M., Smith, Vanessa, Avcin, Tadey, Cimaz, Rolando, Kostik, Mikhail, Lehman, Thomas J. A., Sifuentes-Giraldo, Walter A., Appenzeller, Simone, Janarthanan, Mahesh, Nemkova, Dana, Santos, Maria Jose, Battagliotti, Cristina, Berntson, Lillemor, Bica, Blanca, Brunner, Juergen, Reis, Patricia Costa, Eleftheriou, Despina, Harel, Liora, Horneff, Gerd, Kallinich, Tilmann, Lazarevic, Dragana, Minden, Kirsten, Nielsen, Susan Mary, Uziel, Yosef, Helmus, Nicola, Foeldvari, Ivan, Klotsche, Jens, Kasapcopur, Ozgur, Adrovic, Amra, Torok, Kathryn S., Stanevicha, Valda, Sztajnbok, Flavio, Terreri, Maria Teresa, Alexeeva, Ekaterina, Anton, Jordi, Katsicas, Maria M., Smith, Vanessa, Avcin, Tadey, Cimaz, Rolando, Kostik, Mikhail, Lehman, Thomas J. A., Sifuentes-Giraldo, Walter A., Appenzeller, Simone, Janarthanan, Mahesh, Nemkova, Dana, Santos, Maria Jose, Battagliotti, Cristina, Berntson, Lillemor, Bica, Blanca, Brunner, Juergen, Reis, Patricia Costa, Eleftheriou, Despina, Harel, Liora, Horneff, Gerd, Kallinich, Tilmann, Lazarevic, Dragana, Minden, Kirsten, Nielsen, Susan Mary, Uziel, Yosef, and Helmus, Nicola

Published
2018

35. Effect of Biologic Therapy on Clinical and Laboratory Features of Macrophage Activation Syndrome Associated With Systemic Juvenile Idiopathic Arthritis

Author

Schulert, Grant S., Minoia, Francesca, Bohnsack, John, Cron, Randy Q., Hashad, Soah, KonÉ-Paut, Isabelle, Kostik, Mikhail, Lovell, Daniel, Maritsi, Despoina, Nigrovic, Peter A., Pal, Priyankar, Ravelli, Angelo, Shimizu, Masaki, Stanevicha, Valda, Vastert, Sebastiaan, Woerner, Andreas, de Benedetti, Fabrizio, Grom, Alexei A., Schulert, Grant S., Minoia, Francesca, Bohnsack, John, Cron, Randy Q., Hashad, Soah, KonÉ-Paut, Isabelle, Kostik, Mikhail, Lovell, Daniel, Maritsi, Despoina, Nigrovic, Peter A., Pal, Priyankar, Ravelli, Angelo, Shimizu, Masaki, Stanevicha, Valda, Vastert, Sebastiaan, Woerner, Andreas, de Benedetti, Fabrizio, and Grom, Alexei A.

Published
2018

36. Effect of Biologic Therapy on Clinical and Laboratory Features of Macrophage Activation Syndrome Associated With Systemic Juvenile Idiopathic Arthritis

Author

Immuno/reuma onderzoek 5 (Vastert2), Reumatologie patientenzorg, Child Health, Infection & Immunity, Schulert, Grant S., Minoia, Francesca, Bohnsack, John, Cron, Randy Q., Hashad, Soah, KonÉ-Paut, Isabelle, Kostik, Mikhail, Lovell, Daniel, Maritsi, Despoina, Nigrovic, Peter A., Pal, Priyankar, Ravelli, Angelo, Shimizu, Masaki, Stanevicha, Valda, Vastert, Sebastiaan, Woerner, Andreas, de Benedetti, Fabrizio, Grom, Alexei A., Immuno/reuma onderzoek 5 (Vastert2), Reumatologie patientenzorg, Child Health, Infection & Immunity, Schulert, Grant S., Minoia, Francesca, Bohnsack, John, Cron, Randy Q., Hashad, Soah, KonÉ-Paut, Isabelle, Kostik, Mikhail, Lovell, Daniel, Maritsi, Despoina, Nigrovic, Peter A., Pal, Priyankar, Ravelli, Angelo, Shimizu, Masaki, Stanevicha, Valda, Vastert, Sebastiaan, Woerner, Andreas, de Benedetti, Fabrizio, and Grom, Alexei A.

Published
2018

37. Growth and Puberty in Juvenile Dermatomyositis a Longitudinal Multinatinal Cohort Study

Author

Nordal, Ellen, Pistorio, Angela, Rygg, Marite, Giancane, Gabriella, Hofer, Michael, Melo-Gomes, Jose Antonio, Bica, Blanca, Norambuena, Ximean, Stanevicha, Valda, Ten Cate, Rebecca, Vougiouka, Olga, Brunner, Jurgen, Dannecker, Guenther, Pratsidou-Gertsi, Polyxeni, Gabriele Simonini, Venning, Helen, Pastore, Serena, Ravelli, Angelo, Martini, Alberto, and Ruperto, Nicolino

Published
2017

38. Is there a Difference in the Presentation of male and female Patients with diffuse subtype of juvenile systemic Sclerosis? Results from the juvenile Scleroderma Inception Cohort www.juvenile-scleroderma.com

Author

Foeldvari, Ivan, Klotsche, Jens, Kasapcopur, Ozgur, Adrovic, Amra, Stanevicha, Valda, Terreri, M. T., Alexeeva, Ekaterina, Katsicas, Maria, Smith, Vanessa, Cimaz, Rolando, Kostik, Mikhail, Lehman, Thomas, Anton, Jordi, Sifuentes-Giraldo, W. Alberto, Sztajnbok, Flavio, Avcin, Tadey, Janarthanan, Mahesh, Jose Santos, Maria, Moll, Monika, Nemcova, Dana, Battagliotti, Cristina, Brunner, Jürgen, Eleftheriou, Despina, Harel, Liora, Kallinich, Tilmann, Minden, Kirsten, Nielsen, Susan, Torok, Kathryn, Uziel, Josef, Stevens, Ann, Pilkington, Clarissa, and Helmus, Nicola

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Background: Juvenile systemic sclerosis (jSSc) is an orphan autoimmune disease. Several adult publications looked at the differences between the clinical presentation of male and female patients with Systemic Sclerosis. There is a rarity of data regarding this topic in pediatric jSSc. The juvenile scleroderma[for full text, please go to the a.m. URL], 45. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 31. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 27. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2017

39. Update on the juvenile systemic Sclerosis Inception Cohort Project. Characteristics of the first 97 Patients at first Assessment. www.juvenile-scleroderma.com

Author

Foeldvari, Ivan, Klotsche, Jens, Kasapcopur, Ozgur, Adrovic, Amra, Stanevicha, Valda, Torok, Kathryn, Terreri, M. T., Alexeeva, Ekaterina, Katsicas, Maria, Smith, Vanessa, Sztajnbok, Flavio, Avcin, Tadey, Cimaz, Rolando, Anton, Jordi, Kostik, Mikhail, Lehman, Thomas, Sifuentes-Giraldo, W. Alberto, Appenzeller, Simone, Janarthanan, Mahesh, Moll, Monika, Nemcova, Dana, Jose Santos, Maria, Battagliotti, Cristina, Berntson, Lillemor, Brunner, Jürgen, Eleftheriou, Despina, Harel, Liora, Kallinich, Tilmann, Minden, Kirsten, Nielsen, Susan, Uziel, Yosef, Pilkington, Clarissa, Stevens, Ann, and Helmus, Nicola

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Background: Juvenile systemic sclerosis (jSSc) is an orphan autoimmune disease. Currently just smaller retrospective data exist regarding presentation of organ involvement. In the previous studies assessment of the organ involvement was not standardized. Our project is the first one, where data of jSSc[for full text, please go to the a.m. URL], 45. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 31. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 27. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2017

40. Growth and Puberty in Juvenile Dermatomyositis: A Longitudinal Cohort Study.

Author

Nordal, Ellen, Pistorio, Angela, Rygg, Marite, Giancane, Gabriella, Maghnie, Mohamad, Di Iorgi, Natascia, Flemming, Kristina, Hofer, Michael, Melo‐Gomes, Jose A., Bica, Blanca E. R. G., Brunner, Jurgen, Dannecker, Günther, Gerloni, Valeria, Harjacek, Miroslav, Huppertz, Hans‐Iko, Pratsidou‐Gertsi, Polyxeni, Nielsen, Susan, Stanevicha, Valda, Ten Cate, Rebecca, and Vougiouka, Olga

Abstract

Objective: To study growth and puberty in a multinational longitudinal prospective cohort of children with juvenile dermatomyositis (DM).Methods: Children from 31 countries who were ages <18 years and had juvenile DM in active phase were studied, and analyses of height, weight, and pubertal development were conducted in those who had follow-up visits during a 2-year period and for whom anthropometric data was available.Results: A total of 196 of 275 children (71%) were included. We found a significant reduction in parent-adjusted height Z score over time in female patients (P < 0.0001) and male patients (P = 0.001), but with catch-up growth at the final study visit. Median body mass index Z score peaked at 6 months (P < 0.0001) and was still significantly above baseline at the final study visit, which was at a median of 26 months after baseline (P = 0.007), with no difference between sexes. Female patients with a disease duration ≥12 months after onset had significantly lower parent-adjusted height Z score (P = 0.002) and no 2-year catch-up growth. At the final study visit, growth failure was seen in 20 of 97 female patients (21%) and in 11 of 73 male patients (15%). Height deflection (∆height Z score less than -0.25/year) was observed in 29 of 116 female patients (25%) and 25 of 80 male patients (31.3%). Delayed puberty was seen in 20 of 55 female patients (36.4%) and in 11 of 31 male patients (35.5%). Children in early pubertal stage at baseline had the highest risk of growth failure.Conclusion: Juvenile DM in the active phase and/or its treatment has a significant impact on growth and puberty in affected children. Children with recent onset of puberty or previous growth failure have the highest risk of delayed pubertal development and further growth retardation. [ABSTRACT FROM AUTHOR]

Published
2020
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41. Are diffuse and limited juvenile systemic sclerosis different in clinical presentation? Clinical characteristics of a juvenile systemic sclerosis cohort

Author

Foeldvari, Ivan, primary, Klotsche, Jens, additional, Torok, Kathryn S, additional, Kasapcopur, Ozgur, additional, Adrovic, Amra, additional, Stanevicha, Valda, additional, Terreri, Maria Teresa, additional, Alexeeva, Ekaterina, additional, Katsicas, Maria, additional, Cimaz, Rolando, additional, Kostik, Mikhail, additional, Lehman, Thomas, additional, Sifuentes-Giraldo, Walter-Alberto, additional, Smith, Vanessa, additional, Sztajnbok, Flavio, additional, Avcin, Tadej, additional, Jose Santos, Maria, additional, Moll, Monika, additional, Nemcova, Dana, additional, Battagliotti, Cristina, additional, Eleftheriou, Despina, additional, Janarthanan, Mahesh, additional, Kallinich, Tilmann, additional, Anton, Jordi, additional, Minden, Kirsten, additional, Nielsen, Susan, additional, Uziel, Yosef, additional, and Helmus, Nicola, additional

Published
2018
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42. Effect of Biologic Therapy on Clinical and Laboratory Features of Macrophage Activation Syndrome Associated With Systemic Juvenile Idiopathic Arthritis

Author

Schulert, Grant S., primary, Minoia, Francesca, additional, Bohnsack, John, additional, Cron, Randy Q., additional, Hashad, Soah, additional, KonÉ-Paut, Isabelle, additional, Kostik, Mikhail, additional, Lovell, Daniel, additional, Maritsi, Despoina, additional, Nigrovic, Peter A., additional, Pal, Priyankar, additional, Ravelli, Angelo, additional, Shimizu, Masaki, additional, Stanevicha, Valda, additional, Vastert, Sebastiaan, additional, Woerner, Andreas, additional, de Benedetti, Fabrizio, additional, and Grom, Alexei A., additional

Published
2018
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43. Performance of Juvenile Scleroderma Classification Criteria for Juvenile Systemic Sclerosis : Results from the Jssc Inception Cohort

Author

Klotsche, Jens, Foeldvari, Ivan, Kasapcopur, Ozgur, Smith, Vanessa, Sztajnbok, Flavio, Katsicas, Maria M., Cimaz, Rolando, Janarthanan, Mahesh, Anton, Jordi, Kostik, Mikhail, Nemkova, Dana, Sifuentes-Giraldo, Walter A., Stanevicha, Valda, Torok, Kathryn S., Appenzeller, Simone, Avcin, Tadey, Berntson, Lillemor, Harel, Liora, Kallinich, Tilmann, Santos, Maria Jose, Terreri, Maria Teresa, Uziel, Yosef, Helmus, Nicola, Klotsche, Jens, Foeldvari, Ivan, Kasapcopur, Ozgur, Smith, Vanessa, Sztajnbok, Flavio, Katsicas, Maria M., Cimaz, Rolando, Janarthanan, Mahesh, Anton, Jordi, Kostik, Mikhail, Nemkova, Dana, Sifuentes-Giraldo, Walter A., Stanevicha, Valda, Torok, Kathryn S., Appenzeller, Simone, Avcin, Tadey, Berntson, Lillemor, Harel, Liora, Kallinich, Tilmann, Santos, Maria Jose, Terreri, Maria Teresa, Uziel, Yosef, and Helmus, Nicola

Published
2017

44. Is there a difference in the presentation of male and female patients with juvenile systemic sclerosis? Results from the juvenile scleroderma inception cohort (www.juvenilescleroderma.com)

Author

Foeldvari, Ivan, Klotsche, Jens, Kasapcopur, Ozgur, Adrovic, Amra, Terreri, M. T., Stanevicha, Valda, Katsicas, Maria, Alexeeva, Ekaterina, Sztajnbok, Flavio, Cimaz, Rolando, Kostik, Mikhail, Sifuentes-Giraldo, W. Alberto, Lehman, Thomas, Nemcova, Dana, Moll, Monika, Jose Santos, Maria, Avcin, Tadey, Battagliotti, Cristina, Brunner, Jürgen, Nielsen, Susan, Kallinich, Tilmann, Minden, Kirsten, Janarthanan, Mahesh, Harel, Liora, Uziel, Josef, Eleftheriou, Despina, Torok, Kathryn, and Helmus, Nicola

Subjects
ddc: 610, organ involvement, juvenile systemic sclerosis, 610 Medical sciences, Medicine
Abstract

Background: Juvenile systemic sclerosis (jSSc) is an orphan autoimmune disease. Several adult publications looked at the differences between male and female patients with Systemic Sclerosis. There is rarity of data regarding this topic in pediatric jSSc. The juvenile scleroderma inception cohort (www.juvenilescleroderma.com)[for full text, please go to the a.m. URL], 44. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 30. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 26. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2016

45. Performance of Current Guidelines for Diagnosis of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis

Author

Davi, Sergio Minoia, Francesca Pistorio, Angela Horne, AnnaCarin Consolaro, Alessandro Rosina, Silvia Bovis, Francesca Cimaz, Rolando Gamir, Maria Luz Ilowite, Norman T. and Kone-Paut, Isabelle Feitosa de Oliveira, Sheila Knupp and McCurdy, Deborah Silva, Clovis Artur Sztajnbok, Flavio and Tsitsami, Elena Unsal, Erbil Weiss, Jennifer E. Wulffraat, Nico Abinun, Mario Aggarwal, Amita Apaz, Maria Teresa and Astigarraga, Itziar Corona, Fabrizia Cuttica, Ruben and D'Angelo, Gianfranco Eisenstein, Eli M. Hashad, Soad Lepore, Loredana Mulaosmanovic, Velma Nielsen, Susan Prahalad, Sampath Rigante, Donato Stanevicha, Valda Sterba, Gary and Susic, Gordana Takei, Syuji Trauzeddel, Ralf Zletni, Mabruka and Ruperto, Nicolino Martini, Alberto Cron, Randy Q. and Ravelli, Angelo Paediat Rheumatology Int Trials Or Childhood Arthritis Rheumatology R Pediat Rheumatology Collaborative and Histiocyte Soc

Subjects
body regions, musculoskeletal diseases, fungi, lipids (amino acids, peptides, and proteins), hormones, hormone substitutes, and hormone antagonists
Abstract

ObjectiveTo compare the capacity of the 2004 diagnostic guidelines for hemophagocytic lymphohistiocytosis (HLH-2004) with the capacity of the preliminary diagnostic guidelines for systemic juvenile idiopathic arthritis (JIA)-associated macrophage activation syndrome (MAS) to discriminate MAS complicating systemic JIA from 2 potentially confusable conditions, represented by active systemic JIA without MAS and systemic infection. MethodsInternational pediatric rheumatologists and hemato-oncologists were asked to retrospectively collect clinical information from patients with systemic JIA-associated MAS and confusable conditions. The ability of the guidelines to differentiate MAS from the control diseases was evaluated by calculating the sensitivity and specificity of each set of guidelines and the kappa statistics for concordance with the physician’s diagnosis. Owing to the fact that not all patients were assessed for hemophagocytosis on bone marrow aspirates and given the lack of data on natural killer cell activity and soluble CD25 levels, the HLH-2004 guidelines were adapted to enable the diagnosis of MAS when 3 of 5 of the remaining items (3/5-adapted) or 4 of 5 of the remaining items (4/5-adapted) were present. ResultsThe study sample included 362 patients with systemic JIA and MAS, 404 patients with active systemic JIA without MAS, and 345 patients with systemic infection. The best capacity to differentiate MAS from systemic JIA without MAS was found when the preliminary MAS guidelines were applied. The 3/5-adapted HLH-2004 guidelines performed better than the 4/5-adapted guidelines in distinguishing MAS from active systemic JIA without MAS. The 3/5-adapted HLH-2004 guidelines and the preliminary MAS guidelines with the addition of ferritin levels 500 ng/ml discriminated best between MAS and systemic infections. ConclusionThe preliminary MAS guidelines showed the strongest ability to identify MAS in systemic JIA. The addition of hyperferritinemia enhanced their capacity to differentiate MAS from systemic infections. The HLH-2004 guidelines are likely not appropriate for identification of MAS in children with systemic JIA.

Published
2014

46. Are diffuse and limited juvenile systemic sclerosis different in clinical presentation? Clinical characteristics of a juvenile systemic sclerosis cohort

Author

Foeldvari, Ivan, Klotsche, Jens, Torok, Kathryn S, Kasapcopur, Ozgur, Adrovic, Amra, Stanevicha, Valda, Terreri, Maria Teresa, Alexeeva, Ekaterina, Katsicas, Maria, Cimaz, Rolando, Kostik, Mikhail, Lehman, Thomas, Sifuentes-Giraldo, Walter-Alberto, Smith, Vanessa, Sztajnbok, Flavio, Avcin, Tadej, Jose Santos, Maria, Moll, Monika, Nemcova, Dana, Battagliotti, Cristina, Eleftheriou, Despina, Janarthanan, Mahesh, Kallinich, Tilmann, Anton, Jordi, Minden, Kirsten, Nielsen, Susan, Uziel, Yosef, and Helmus, Nicola

Abstract

Introduction: Juvenile systemic sclerosis is an orphan disease. Currently, the majority of juvenile systemic sclerosis cohort studies are retrospective in design without standardized assessment. This study was conducted prospectively to investigate the difference in manifestations of limited cutaneous juvenile systemic sclerosis and diffuse cutaneous juvenile systemic sclerosis subtypes. An additional aim was to compare these data to other juvenile systemic sclerosis cohorts and a large adult systemic sclerosis cohort.Methods: Patients fulfilling the Paediatric Rheumatology European Society juvenile systemic sclerosis classification criteria were included. Clinical characteristics and patient-related outcomes were assessed.Results: In all, 88 patients with a mean disease duration of 3.5 years were enrolled, 72.5% with diffuse cutaneous juvenile systemic sclerosis with a mean modified Rodnan Skin score of 18 and 27.5% with limited cutaneous juvenile systemic sclerosis with mean modified Rodnan Skin score of 9. The mean age at the onset of Raynaud’s and first non-Raynaud’s symptoms was similar in both groups, approximately 9 and 10.5 years. Active digital tip ulcerations were present in 29% diffuse cutaneous juvenile systemic sclerosis and none in the limited cutaneous juvenile systemic sclerosis subjects (p = 0.005). Of those with cardiopulmonary testing, 3% of diffuse cutaneous juvenile systemic sclerosis and 23% of limited cutaneous juvenile systemic sclerosis group had cardiac involvement (p = 0.015), and 41% diffuse cutaneous juvenile systemic sclerosis and 22% of the limited cutaneous juvenile systemic sclerosis group had pulmonary involvement (p = 0.009). Physician global disease damage assessment was higher in the diffuse cutaneous juvenile systemic sclerosis group compared to the limited cutaneous juvenile systemic sclerosis group: 35 and 15 (p = 0.021).Discussion: The majority of this international juvenile systemic sclerosis cohort had diffuse cutaneous juvenile systemic sclerosis (72.5%) with more frequent vascular and pulmonary involvement compared to the limited cutaneous group, who had increased cardiac involvement. Our cohort reflects prior findings of published juvenile systemic sclerosis cohorts and emphasizes a difference in the presentation compared to adult-onset systemic sclerosis.

Published
2019
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47. The provisional Paediatric Rheumatology International Trials Organisation/American College of Rheumatology/European League Against Rheumatism Disease activity core set for the evaluation of response to therapy in juvenile dermatomyositis: a prospective validation study

Author

Ruperto, Nikolino, Ravelli, Angelo, Pistorio, Angela, Ferriani, Virginia, Calvo, Immaculada, Ganser, Gerd, Brunner, Jurgen, Dannecker, Guenther, Silva Clovis, Arthur, Stanevicha, Valda, Cate, Rebecca Ten, van Suijlekom-Smit, Lisette W. A., Voygioyka, Olga, Fischbach, Michel, Foeldvari, Ivan, Hilario, Odete, Modesto, Consuelo, Saurenmann, Rotraud K., Sauvain, Marie-Josephe, Scheibel, Iloite, Sommelet, Daniele, Tambić-Bukovac, Lana, Barcellona, Roberto, Brik, Riva, Ehl, Stephan, Jovanović, Mirjana, Rovensky, Jozef, Bagnasco, Francesca, Lovell, Daniel J., Martini, Alberto, Paediatric Rheumatology International Trials Organisation (PRINTO), and Pediatric Rheumatology Collaborative Study Group (PRCSG)

Subjects
juvenile dermatomyositis, therapy, response, validation
Abstract

OBJECTIVE: To validate a core set of outcome measures for the evaluation of response to treatment in patients with juvenile dermatomyositis (DM). METHODS: In 2001, a preliminary consensus-derived core set for evaluating response to therapy in juvenile DM was established. In the present study, the core set was validated through an evidence-based, large-scale data collection that led to the enrollment of 294 patients from 36 countries. Consecutive patients with active disease were assessed at baseline and after 6 months. The validation procedures included assessment of feasibility, responsiveness, discriminant and construct ability, concordance in the evaluation of response to therapy between physicians and parents, redundancy, internal consistency, and ability to predict a therapeutic response. RESULTS: The following clinical measures were found to be feasible, and to have good construct validity, discriminative ability, and internal consistency ; furthermore, they were not redundant, proved responsive to clinically important changes in disease activity, and were associated strongly with treatment outcome and thus were included in the final core set: 1) physician's global assessment of disease activity, 2) muscle strength, 3) global disease activity measure, 4) parent's global assessment of patient's well-being, 5) functional ability, and 6) health-related quality of life. CONCLUSION: The members of the Paediatric Rheumatology International Trials Organisation, with the endorsement of the American College of Rheumatology and the European League Against Rheumatism, propose a core set of criteria for the evaluation of response to therapy that is scientifically and clinically relevant and statistically validated. The core set will help standardize the conduct and reporting of clinical trials and assist practitioners in deciding whether a child with juvenile DM has responded adequately to therapy.

Published
2008

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