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162 results on '"Stanford, Miles R."'

2. Endogenous Bacterial Endophthalmitis

Author

Gale, Richard P., Zuberbuhler, Bruno, Stanford, Miles R., Zierhut, Manfred, editor, Pavesio, Carlos, editor, Ohno, Shigeaki, editor, Orefice, Fernando, editor, and Rao, Narsing A., editor

Published
2016
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4. Electrophysiological Assessment in Birdshot Chorioretinopathy: Flicker Electroretinograms Recorded With a Handheld Device

Author

Waldie, Anna M., primary, Hobby, Angharad E., additional, Chow, Isabelle, additional, Cornish, Elisa E., additional, Indusegaran, Mathura, additional, Pekacka, Aleksandra, additional, Nguyen, Phuc, additional, Fraser, Clare, additional, Binns, Alison M., additional, Stanford, Miles R., additional, Hammond, Christopher J., additional, McCluskey, Peter J., additional, Grigg, John R., additional, and Mahroo, Omar A., additional

Published
2022
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18. Role of gamma delta T cells in pathogenesis and diagnosis of Behcet's disease

Author

Hasan, Adam, Fortune, Farida, Wilson, Amanda, Warr, Kevin, Shinnick, Thomas, Mizushima, Yutaka, Zee, Ruurd van der, Stanford, Miles R., Sanderson, Jeremy, and Lehner, Thomas

Subjects
Behcet's disease -- Diagnosis, T cell proliferation -- Measurement, Heat shock proteins -- Physiological aspects, Microbiological assay
Published
1996

25. Aspergillus fumigatus Endophthalmitis with Necrotizing Scleritis following Pars Plana Vitrectomy

Author

Gruener, Anna M., Allen, Felicity, Stanford, Miles R., and Graham, Elizabeth M.

Subjects
genetic structures, Article Subject, eye diseases
Abstract

We present a case of Aspergillus fumigatus endophthalmitis complicated by necrotizing scleritis in a 68-year-old man with diet-controlled diabetes, after retinal detachment repair. He was initially treated with systemic steroids for surgically induced necrotizing scleritis following routine pars plana vitrectomy. An additional diagnosis of endophthalmitis was made when the patient developed a hypopyon. Repeat vitreous culture isolated Aspergillus fumigatus. Symptoms improved following antifungal treatment leaving the patient with scleromalacia and an advanced postoperative cataract. Fungal scleritis and endophthalmitis are rare complications of intraocular surgery with sight-threatening consequences, and, as this case demonstrates, may even occur concomitantly. The overlapping features of both conditions can make differentiating one from the other difficult. A fungal aetiology should be considered in cases of postoperative scleritis and endophthalmitis that are protracted and refractory to standard therapy. Even in cases of early diagnosis and treatment, visual outcomes in Aspergillus endophthalmitis and scleritis are variable and often disappointing, not infrequently necessitating enucleation of a painful blind eye.

Published
2016
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26. Genotype analysis of polymorphisms in autoimmune susceptibility genes, CTLA-4 and PTPN22, in an acute anterior uveitis cohort

Author

Martin, Tammy M., Bye, Louise, Modi, Neil, Stanford, Miles R., Vaughan, Robert, Smith, Justine R., Wade, N. Kevin, Mackensen, Friederike, Suhler, Eric B., Rosenbaum, James T., and Wallace, Graham R.

Subjects
Male, Chi-Square Distribution, Genotype, Autoimmunity, Protein Tyrosine Phosphatase, Non-Receptor Type 22, Polymorphism, Single Nucleotide, Uveitis, Anterior, Gene Frequency, Antigens, CD, Case-Control Studies, Acute Disease, Humans, CTLA-4 Antigen, Female, Genetic Predisposition to Disease, Research Article
Abstract

Purpose Acute anterior uveitis (AAU) is the most common form of uveitis and is thought to be autoimmune in nature. Recent studies have described genes that act as master controllers of autoimmunity. Protein tyrosine phosphatase type 22 (PTPN22) and Cytotoxic T lymphocyte antigen-4 (CTLA-4) are two of these genes, and single nucleotide polymorphisms (SNPs) in the genes encoding these molecules have been associated with several autoimmune diseases. In this study we have analyzed SNPs in PTPN22 and CTLA-4 in patients with AAU. Methods The functional protein tyrosine phosphatase type 22 (PTPN22) SNP (R620W rs2476601, 1858C/T), and two CTLA-4 SNPs (rs5742909, −318C/T and rs231775, 49A/G) were analyzed in 140 patients with AAU and 92 healthy controls by sequence-specific primer -polymerase chain reaction (SSP-PCR). Data was analyzed by χ2 analysis and Fisher’s exact test. Results There was no significant association between PTPN22 620W, CTLA-4 −318C/T, or CTLA-4 49A/G and AAU. Similarly, there was no association with the three SNPs when patients were classified by race or gender. Finally, there was no association with the presence of ankylosing spondylitis in the patient cohort. Conclusions The data do not support an association between SNPs in PTPN22 and CTLA-4, genes regarded as genetic master switches of autoimmunity. This raises the issue of the etiology of AAU and the possibility that it should be regarded as an autoinflammatory rather than an autoimmune condition.

Published
2009

32. Genome-Wide Association Study in an Admixed Case Series Reveals IL12A as a New Candidate in Behçet Disease

Author

Kappen, Jasper H., primary, Medina-Gomez, Carolina, additional, Hagen, P. Martin van, additional, Stolk, Lisette, additional, Estrada, Karol, additional, Rivadeneira, Fernando, additional, Uitterlinden, Andre G., additional, Stanford, Miles R., additional, Ben-Chetrit, Eldat, additional, Wallace, Graham R., additional, Soylu, Merih, additional, and Laar, Jan A.M. van, additional

Published
2015
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39. Acute Retinal Necrosis

Author

Wong, Roger, primary, Pavesio, Carlos E., additional, Laidlaw, D. Alistair H., additional, Williamson, Tom H., additional, Graham, Elizabeth M., additional, and Stanford, Miles R., additional

Published
2010
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41. IL-10 Genotype Analysis in Patients with Behçet’s Disease

Author

Wallace, Graham R., primary, Kondeatis, Elly, additional, Vaughan, Robert W., additional, Verity, David H., additional, Chen, Yuanneng, additional, Fortune, Farida, additional, Madanat, Wafa, additional, Kanawati, Charlie A., additional, Graham, Elizabeth M., additional, and Stanford, Miles R., additional

Published
2007
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