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1,757 results on '"Stang, Peter J."'

5. A NIR‐Light‐Activated and Lysosomal‐Targeted Pt(II) Metallacycle for Highly Potent Evoking of Immunogenic Cell Death that Potentiates Cancer Immunotherapy of Deep‐Seated Tumors.

Author

Li, Chonglu, Tu, Le, Xu, Yuling, Li, Meiqin, Du, Jiaxing, Stang, Peter J., Sun, Yan, and Sun, Yao

Subjects
PLATINUM, CELL death, IMMUNOTHERAPY, REACTIVE oxygen species, T cells, TUMORS
Abstract

Though platinum (Pt)‐based complexes have been recently exploited as immunogenic cell death (ICD) inducers for activating immunotherapy, the effective activation of sufficient immune responses with minimal side effects in deep‐seated tumors remains a formidable challenge. Herein, we propose the first example of a near‐infrared (NIR) light‐activated and lysosomal targeted Pt(II) metallacycle (1) as a supramolecular ICD inducer. 1 synergistically potentiates immunomodulatory response in deep‐seated tumors via multiple‐regulated approaches, involving NIR light excitation, boosted reactive oxygen species (ROS) generation, good selectivity between normal and tumor cells, and enhanced tumor penetration/retention capabilities. Specifically, 1 has excellent depth‐activated ROS production (~7 mm), accompanied by strong anti‐diffusion and anti‐ROS quenching ability. In vitro experiments demonstrate that 1 exhibits significant cellular uptake and ROS generation in tumor cells as well as respective multicellular tumor spheroids. Based on these advantages, 1 induces a more efficient ICD in an ultralow dose (i.e. 5 μM) compared with the clinical ICD inducer‐oxaliplatin (300 μM). In vivo, vaccination experiments further demonstrate that 1 serves as a potent ICD inducer through eliciting CD8+/CD4+ T cell response and Foxp3+ T cell depletion with negligible adverse effects. This study pioneers a promising avenue for safe and effective metal‐based ICD agents in immunotherapy. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Transparency in authors’ contributions and responsibilities to promote integrity in scientific publication

Author

McNutt, Marcia K, Bradford, Monica, Drazen, Jeffrey M, Hanson, Brooks, Howard, Bob, Jamieson, Kathleen Hall, Kiermer, Véronique, Marcus, Emilie, Pope, Barbara Kline, Schekman, Randy, Swaminathan, Sowmya, Stang, Peter J, and Verma, Inder M

Subjects
authorship principles, research transparency, scientific integrity
Abstract

In keeping with the growing movement in scientific publishing toward transparency in data and methods, we propose changes to journal authorship policies and procedures to provide insight into which author is responsible for which contributions, better assurance that the list is complete, and clearly articulated standards to justify earning authorship credit. To accomplish these goals, we recommend that journals adopt common and transparent standards for authorship, outline responsibilities for corresponding authors, adopt the Contributor Roles Taxonomy (CRediT) (docs.casrai.org/CRediT) methodology for attributing contributions, include this information in article metadata, and require authors to use the ORCID persistent digital identifier (https://orcid.org). Additionally, we recommend that universities and research institutions articulate expectations about author roles and responsibilities to provide a point of common understanding for discussion of authorship across research teams. Furthermore, we propose that funding agencies adopt the ORCID identifier and accept the CRediT taxonomy. We encourage scientific societies to further authorship transparency by signing on to these recommendations and promoting them through their meetings and publications programs.

Published
2018

26. A cyclic bis[2]catenane metallacage

Author

Wang, Yiliang, Zhang, Yicheng, Zhou, Zhixuan, Vanderlinden, Ryan T., Li, Bin, Song, Bo, Li, Xiaopeng, Cui, Lei, Li, Jian, Jia, Xueshun, Fang, Jianhui, Li, Chunju, and Stang, Peter J.

Published
2020
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31. Synthesis of Six-Component Metallodendrimers via [3 + 3] Coordination-Driven Self-Assembly

Author

Yang, Hai-Bo, Northrop, Brian H., Zheng, Yao-Rong, Ghosh, Koushik, Lyndon, Matthew M., Muddiman, David C., and Stang, Peter J.

Abstract

A new class of 120° dendritic di-Pt(II) acceptor subunits has been designed and synthesized, from which six-component hexagonal metallodendrimers were easily formed with 120° dendritic dipyridine donors via [3 + 3] coordination-driven self-assembly. The structures of all metallodendrimers are confirmed by multinuclear NMR, ESI-TOF-MS/ESI-FTMS, and elemental analysis. MMFF force-field simulations indicates that all metallodendrimers have a hexagonal ring with an internal radius of approximately 1.4 nm.

Published
2024
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32. Geometry Directed Self-Selection in the Coordination-Driven Self-Assembly of Irregular Supramolecular Polygons

Author

Zheng, Yao-Rong, Northrop, Brian H, Yang, Hai-Bo, Zhao, Liang, and Stang, Peter J.

Abstract

The self-assembly of irregular metallo-supramolecular hexagons and parallelograms has been achieved in a self-selective manner upon mixing 120° unsymmetrical dipyridyl ligands with 60° or 120° organoplatinum acceptors in a 1:1 ratio. The polygons have been characterized using 31P and 1H multinuclear NMR spectroscopy and electrospray ionization mass spectrometry (ESI-MS) as well as X-ray crystallography. Geometric features of the molecular subunits direct the self-selection process, which is supported by molecular force field computations.

Published
2024
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38. Coordination-Driven Supramolecular Macromolecules via the Directional Bonding Approach

Author

Cook, Timothy R., Stang, Peter J., Abe, Akihiro, Series editor, Albertsson, Ann-Christine, Series editor, Coates, Geoffrey W., Series editor, Genzer, Jan, Series editor, Kobayashi, Shiro, Series editor, Lee, Kwang-Sup, Series editor, Leibler, Ludwik, Series editor, Long, Timothy E., Series editor, Möller, Martin, Series editor, Okay, Oguz, Series editor, Tang, Ben Zhong, Series editor, Terentjev, Eugene M., Series editor, Vicent, Maria J., Series editor, Voit, Brigitte, Series editor, Wiesner, Ulrich, Series editor, Zhang, Xi, Series editor, and Percec, Virgil, editor

Published
2013
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44. Metallacage-based enhanced PDT strategy for bacterial elimination via inhibiting endogenous NO production.

Author

Kai Huang, Jinbing Wang, Ai Zhuang, Qian Liu, Fupeng Li, Kai Yuan, Yiqi Yang, Yihao Liu, Haishuang Chang, Yakun Liang, Yan Sun, Xuzhou Yan, Tingting Tang, Stang, Peter J., and Shengbing Yang

Subjects
PHOTODYNAMIC therapy, DRUG resistance in bacteria, BACTERIAL diseases, NITRIC-oxide synthases
Abstract

Antibiotics are among the most used weapons in fighting microbial infections and have greatly improved the quality of human life. However, bacteria can eventually evolve to exhibit antibiotic resistance to almost all prescribed antibiotic drugs. Photodynamic therapy (PDT) develops little antibiotic resistance and has become a promising strategy in fighting bacterial infection. To augment the killing effect of PDT, the conventional strategy is introducing excess ROS in various ways, such as applying high light doses, high photosensitizer concentrations, and exogenous oxygen. In this study, we report a metallacage-based PDT strategy that minimizes the use of ROS by jointly using gallium-metal organic framework rods to inhibit the production of bacterial endogenous NO, amplify ROS stress, and enhance the killing effect. The augmented bactericidal effect was demonstrated both in vitro and in vivo. This proposed enhanced PDT strategy will provide a new option for bacterial ablation. [ABSTRACT FROM AUTHOR]

Published
2023
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