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3. DNA and RNA obtained from Bouin's fixed tissues

Author

Bonin, S., Petrera, F., Rosai, J., and Stanta, G.

Subjects
Polymerase chain reaction -- Methods, Polymerase chain reaction -- Research, Nucleic acids -- Separation, Nucleic acids -- Methods, Nucleic acids -- Research, Health
Published
2005

4. Insulin-like growth factor system gene expression in women type 2 diabetes and breast cancer

Author

Nardon, E, Buda, I, Stanta, G, Buratti, E, Fonda, M, and Cattin, L

Subjects
Genetic markers -- Physiological aspects -- Research -- Methods -- Genetic aspects -- Health aspects, Women patients -- Health aspects -- Care and treatment -- Methods -- Physiological aspects -- Research, Clinical pathology -- Research -- Physiological aspects -- Health aspects -- Methods, Gene expression -- Physiological aspects -- Research -- Methods -- Genetic aspects -- Health aspects, Diabetes -- Demographic aspects -- Health aspects -- Complications and side effects -- Research -- Genetic aspects -- Care and treatment, Messenger RNA -- Genetic aspects -- Methods -- Research -- Physiological aspects -- Health aspects, Proteins -- Physiological aspects -- Genetic aspects -- Health aspects -- Research -- Methods, Breast -- Biopsy, Insulin-like growth factor 1 -- Genetic aspects -- Physiological aspects -- Health aspects -- Research -- Methods, Breast cancer -- Health aspects -- Research -- Care and treatment -- Genetic aspects -- Complications and side effects, Health
Abstract

Background/Aims: A twofold increased risk for breast cancer has been reported recently for women with late onset diabetes. Most studies showed that there were differences in serum concentrations of insulin-like [...]

Published
2003

14. Quality Matters : 2016 Annual Conference of the National Infrastructures for Biobanking

Author

Doucet, M., Becker, K. F., Björkman, J., Bonnet, J., Clément, B., Daidone, M. -G, Duyckaerts, C., Erb, G., Haslacher, H., Hofman, P., Huppertz, B., Junot, C., Lundeberg, Joakim, Metspalu, A., Lavitrano, M., Litton, J. -E, Moore, H. M., Morente, M., Naimi, B. -Y, Oelmueller, U., Ollier, B., Parodi, B., Ruan, L., Stanta, G., Turano, P., Vaught, J., Watson, P., Wichmann, H. -E, Yuille, M., Zaomi, M., Zatloukal, K., Dagher, G., Doucet, M., Becker, K. F., Björkman, J., Bonnet, J., Clément, B., Daidone, M. -G, Duyckaerts, C., Erb, G., Haslacher, H., Hofman, P., Huppertz, B., Junot, C., Lundeberg, Joakim, Metspalu, A., Lavitrano, M., Litton, J. -E, Moore, H. M., Morente, M., Naimi, B. -Y, Oelmueller, U., Ollier, B., Parodi, B., Ruan, L., Stanta, G., Turano, P., Vaught, J., Watson, P., Wichmann, H. -E, Yuille, M., Zaomi, M., Zatloukal, K., and Dagher, G.

Abstract

QC 20170621

Published
2017
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15. Liquid dynamic medicine and N-of-1 clinical trials: A change of perspective in oncology research

Author

Silvestris, N, Ciliberto, G, De Paoli, P, Apolone, G, Lavitrano, M, Pierotti, M, Stanta, G, Pierotti, MA, Silvestris, N, Ciliberto, G, De Paoli, P, Apolone, G, Lavitrano, M, Pierotti, M, Stanta, G, and Pierotti, MA

Abstract

The increasing use of genomics to define the pattern of actionable mutations and to test and validate new therapies for individual cancer patients, and the growing application of liquid biopsy to dynamically track tumor evolution and to adapt molecularly targeted therapy according to the emergence of tumor clonal variants is shaping modern medical oncology., In order to better describe this new therapeutic paradigm we propose the term "Liquid dynamic medicine" in the place of "Personalized or Precision medicine". Clinical validation of the "Liquid dynamic medicine" approach is best captured by N-of-1 trials where each patient acts as tester and control of truly personalized therapies.

Published
2017

16. Quality Matters: 2016 Annual Conference of the National Infrastructures for Biobanking

Author

Doucet, M, Becker, K, Björkman, J, Bonnet, J, Clément, B, Daidone, M, Duyckaerts, C, Erb, G, Haslacher, H, Hofman, P, Huppertz, B, Junot, C, Lundeberg, J, Metspalu, A, Lavitrano, M, Litton, J, Moore, H, Morente, M, Naimi, B, Oelmueller, U, Ollier, B, Parodi, B, Ruan, L, Stanta, G, Turano, P, Vaught, J, Watson, P, Wichmann, H, Yuille, M, Zaomi, M, Zatloukal, K, Dagher, G, Becker, KF, Daidone, MG, Litton, JE, Moore, HM., Naimi, BY, Wichmann, HE, Doucet, M, Becker, K, Björkman, J, Bonnet, J, Clément, B, Daidone, M, Duyckaerts, C, Erb, G, Haslacher, H, Hofman, P, Huppertz, B, Junot, C, Lundeberg, J, Metspalu, A, Lavitrano, M, Litton, J, Moore, H, Morente, M, Naimi, B, Oelmueller, U, Ollier, B, Parodi, B, Ruan, L, Stanta, G, Turano, P, Vaught, J, Watson, P, Wichmann, H, Yuille, M, Zaomi, M, Zatloukal, K, Dagher, G, Becker, KF, Daidone, MG, Litton, JE, Moore, HM., Naimi, BY, and Wichmann, HE

Published
2017

18. [Time trend in cancer incidence among 0-24 year-old residents of the Province of Trieste, Italy, 1972-2003]

Author

Brunetti D, Tamaro P, Tiribelli M, Fanin R, Stanta G, Ga, Zanazzo, Peruzzo P, Carabolante F, Kiren V, Diego Serraino, Brunetti, D, Tamaro, Paolo, Tiribelli, M, Fanin, R, Stanta, G, Zanazzo, Ga, Peruzzo, P, Carabolante, F, Kiren, V, and Serraino, D.

Subjects
Male, cancer incidence, Incidence, Infant, Newborn, Infant, Young Adult, province of Trieste, Bias, Italy, Child, Preschool, Neoplasms, Linear Models, Humans, Female, Poisson Distribution, Registries, Age of Onset, Morbidity, Child, Retrospective Studies
Abstract

OBJECTIVE: to report and analyse time trends in cancer incidence among children (0-14 years of age), adolescents (15-19 years) and young adults (20-24 years) living in the Italian province of Trieste (2003 population, 242,000), between 1972 and 2003. DESIGN: population-based study of descriptive epidemiology. Setting and participants: the new cases of cancer diagnosed to the residents of the province of Trieste below 25 years of age were extracted from the database of the Trieste Cancer Registry (period 1972-1994) and from the database of the Friuli-Venezia Giulia Cancer Registry (period 1995-2003), according to the International Classification of Childhood Cancer (3rd edition). MAIN OUTCOME MEASURES: age-specific and age-standardized (Italian 1981 census population as standard) incidence rates, by diagnostic group, sex and period of diagnosis. Time trend in incidence was analysed by using a Poisson regression model adjusted for calendar year, sex and 5 year age-group, and was expressed as annual percent change (APC) in rates. RESULTS: in the period 1972-2003, the new cases of cancer were 168 in the age-group 0-14 years, 79 in the age-group 15-19 years and 111 in the age-group 20-24 years, while the person-years at risk were respectively: 1,050,027; 431,673; 496,450. The APC in the incidence of all cancers combined was 2.3% (IC 95% 0.6%-3.9%) in children, 4.4% (IC 95% 1.8%-7.1%) in adolescents and 5.1% (IC 95% 2.8%-7.5%) in young adults. Hodgkin lymphomas (APC =12.7%; IC 95% 2.6%-23.7%; 7 cases) in the age-group 0-14 years, skin melanomas and carcinomas (APC =8.2%; IC 95% 4.5%-12.0%; 49 cases) and central nervous system tumours (APC = 6.4%; IC 95% 1.5%-11.5%; 25 cases) in the age-group 15-24 years were the malignancies characterised by the highest increase in incidence. CONCLUSION: the increase in incidence rates observed in this study can be only partly explained by the small number of ascertained cases, by an improvement in diagnostic techniques and by more efficient registration. However, few environmental and hereditary factors are consistently associated with cancers affecting young people. Therefore, it is imperative to continue to carry out descriptive and analytical studies with primary prevention as the ultimate aim.

Published
2009

19. The extreme longevity: the state of the art in Italy

Author

FRANCESCHI, CLAUDIO, CAPRI, MIRIAM, SALVIOLI, STEFANO, VALENSIN, SILVANA, Motta L., Motta M., Malaguarnera M., Vasto S., Candore G., Caruso C., Capurso A., Panza F., Solfrizzi V., D'Introno A., Colacicco A. M., Capurso S., Bennati E., Maugeri D., Rapisarda R., Franzone A., Ferlito L., De Benedictis G., Berardelli M., Masotti G., Petruzzi E., Petruzzi I., Pinzani P., Monti D., Antonini F. M., Capurso C., Nicita Mauro V., Lo Balbo C., Mento A., Nicita Mauro C., Maltese G., Basile G., Mari D., Coppola R., Provenzano R., Salvioli G., Baldelli M. V., Mussi C., Varricchio M., Barbieri M., Gambardella A., Paolisso G., Colonna Romano G., Lio D., Sansoni P., Vescovini R., Galli C., Biasini C., Telera A., Passeri G., Passeri M., Ferrari E., Cravello L., Barili L., Solerte S. B., Fioravanti M., Magri F., Fagnoni F., Senin U., Mecocci P., Cherubini A., Marigliano V., Tafaro L., Cicconetti P., Tombesi F., Tombolillo M. T., Ettore E., Forconi S., Boschi S., Righi G. A., Guerrini M., Giarelli L., Stanta G., Ferrucci L., Ble A., Metter E. J., Guralnik J. M., Pacifici R., Zuccaro P., Palmi I., Branca S., Fradà G., Motta F., Crimi G., FRANCESCHI C, MOTTA L, MOTTA M, MALAGUARNERA M, CAPRI M, VASTO S, CANDORE G, CARUSO C, IMUSCE, Franceschi C., Motta L., Motta M., Malaguarnera M., Capri M., Vasto S., Candore G., Caruso C., Capurso A., Panza F., Solfrizzi V., D'Introno A., Colacicco A.M., Capurso S., Salvioli S., Valensin S., Bennati E., Maugeri D., Rapisarda R., Franzone A., Ferlito L., De Benedictis G., Berardelli M., Masotti G., Petruzzi E., Petruzzi I., Pinzani P., Monti D., Antonini F.M., Capurso C., Nicita-Mauro V., Lo Balbo C., Mento A., Nicita-Mauro C., Maltese G., Basile G., Mari D., Coppola R., Provenzano R., Salvioli G., Baldelli M.V., Mussi C., Varricchio M., Barbieri M., Gambardella A., Paolisso G., Colonna-Romano G., Lio D., Sansoni P., Vescovini R., Galli C., Biasini C., Telera A., Passeri G., Passeri M., Ferrari E., Cravello L., Barili L., Solerte S.B., Fioravanti M., Magri F., Fagnoni F., Senin U., Mecocci P., Cherubini A., Marigliano V., Tafaro L., Cicconetti P., Tombesi F., Tombolillo M.T., Ettore E., Forconi S., Boschi S., Righi G.A., Guerrini M., Giarelli L., Stanta G., Ferrucci L., Ble A., Metter E.J., Guralnik J.M., Pacifici R., Zuccaro P., Palmi I., Branca S., Fradà G., Motta F., and Crimi G.

Subjects
Gerontology, Male, Aging, media_common.quotation_subject, Health Status, Longevity, Biochemistry, Endocrinology, State (polity), Development economics, Genetics, Diabetes Mellitus, Medicine, Humans, Molecular Biology, media_common, Aged, 80 and over, business.industry, Cell Biology, Gene Expression Regulation, Italy, Cardiovascular Diseases, Immune System, Extreme longevity tracking, Female, business
Published
2008

20. Calcium metabolism and vitamin D in the extreme longevity

Author

Passeri, G, Vescovini, R, Sansoni, P, Galli, C, Franceschi, C, Passeri, M, Italian Multicentric Study on Centenarians 87 Collaborators, Motta, M, Motta, L, Capurso, A, Panza, F, Solfrizzi, V, D'Introno, A, Colacicco, Am, Capurso, S, Capri, M, Salvioli, S, Valensin, S, Bennati, E, Malaguarnera, M, Maugeri, D, Rapisarda, R, Franzone, A, Ferlito, L, De Benedictis, G, Berardelli, M, Masotti, G, Petruzzi, E, Petruzzi, I, Pinzani, P, Monti, D, Antonini, Fm, Capurso, C, Nicita Mauro, V, Lo Balbo, C, Mento, A, Nicita Mauro, C, Maltese, G, Basile, G, Mari, D, Coppola, R, Provenzano, R, Salvioli, G, Baldelli, Mv, Mussi, C, Varricchio, M, Barbieri, M, Gambardella, A, Paolisso, G, Caruso, C, Candore, G, Colonna Romano, G, Lio, D, Biasini, C, Telera, A, Ferrari, E, Cravello, L, Barili, L, Solerte, Sb, Fioravanti, M, Magri, F, Fagnoni, F, Senin, Umberto, Mecocci, Patrizia, Cherubini, Antonio, Marigliano, V, Tafaro, L, Cicconetti, P, Tombesi, F, Tombolillo, Mt, Ettore, E, Forconi, S, Boschi, S, Righi, Ga, Guerrini, M, Giarelli, L, Stanta, G, Ferrucci, L, Ble, A, Metter, Ej, Guralnik, Jm, Pacifici, R, Zuccaro, P, Palmi, I, Branca, S, Fradà, G, Motta, F, Crimi, G., Passeri, G, Vescovini, R, Sansoni, P, Galli, C, Franceschi, C, Passeri, M, Paolisso, G, Barbieri, M, Italian Multicentric Study on Centenarians, (IMUSCE)., Passeri G., Vescovini R., Sansoni P., Galli C., Franceschi C., Passeri M., Italian Multicentric Study on Centenarians (IMUSCE), Motta M., Motta L., Capurso A., Panza F., Solfrizzi V., D'Introno A., Colacicco A.M., Capurso S., Capri M., Salvioli S., Valensin S., Bennati E., Malaguarnera M., Maugeri D., Rapisarda R., Franzone A., Ferlito L., De Benedictis G., Berardelli M., Masotti G., Petruzzi E., Petruzzi I., Pinzani P., Monti D., Antonini F.M., Capurso C., Nicita-Mauro V., Lo Balbo C., Mento A., Nicita-Mauro C., Maltese G., Basile G., Mari D., Coppola R., Provenzano R., Salvioli G., Baldelli M.V., Mussi C., Varricchio M., Barbieri M., Gambardella A., Paolisso G., Caruso C., Candore G., Colonna-Romano G., Lio D., Biasini C., Telera A., Ferrari E., Cravello L., Barili L., Solerte S.B., Fioravanti M., Magri F., Fagnoni F., Senin U., Mecocci P., Cherubini A., Marigliano V., Tafaro L., Cicconetti P., Tombesi F., Tombolillo M.T., Ettore E., Forconi S., Boschi S., Righi G.A., Guerrini M., Giarelli L., Stanta G., Ferrucci L., Ble A., Metter E.J., Guralnik J.M., Pacifici R., Zuccaro P., Palmi I., Branca S., Fradà G., Motta F., Crimi G., Dipartimento di Medicina Interna e Scienze Biomediche, University of Parma = Università degli studi di Parma [Parme, Italie], Dipartimento di Patologia Sperimentale, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Motta, M, Motta, L, Capurso, A, Panza, F, Solfrizzi, V, D'Introno, A, Colacicco, Am, Capurso, S, Capri, M, Salvioli, S, Valensin, S, Bennati, E, Malaguarnera, M, Maugeri, D, Rapisarda, R, Franzone, A, Ferlito, L, De Benedictis, G, Berardelli, M, Masotti, G, Petruzzi, E, Petruzzi, I, Pinzani, P, Monti, D, Antonini, Fm, Capurso, C, Nicita Mauro, V, Lo Balbo, C, Mento, A, Nicita Mauro, C, Maltese, G, Basile, G, Mari, D, Coppola, R, Provenzano, R, Salvioli, G, Baldelli, Mv, Mussi, C, Varricchio, M, Gambardella, A, Caruso, C, Candore, G, Colonna Romano, G, Lio, D, Biasini, C, Telera, A, Ferrari, E, Cravello, L, Barili, L, Solerte, Sb, Fioravanti, M, Magri, F, Fagnoni, F, Senin, U, Mecocci, P, Cherubini, A, Marigliano, V, Tafaro, L, Cicconetti, P, Tombesi, F, Tombolillo, Mt, Ettore, E, Forconi, S, Boschi, S, Righi, Ga, Guerrini, M, Giarelli, L, Stanta, Giorgio, Ferrucci, L, Ble, A, Metter, Ej, Guralnik, Jm, Pacifici, R, Zuccaro, P, Palmi, I, Branca, S, Fradà, G, Motta, F, and Crimi, G.

Subjects
Male, Aging, Bone density, Osteoporosis, Parathyroid hormone, Vitamin D, Calcium metabolism, Extreme longevity, Bone fractures, Self-sufficiency, Biochemistry, Bone remodeling, 0302 clinical medicine, Endocrinology, Bone Density, calcium metabolism, vitamin D, longevity, ComputingMilieux_MISCELLANEOUS, Aged, 80 and over, 0303 health sciences, 3. Good health, Parathyroid Hormone, 030220 oncology & carcinogenesis, Medicine, Female, Risk, medicine.medical_specialty, Longevity, Bone resorption, vitamin D deficiency, Article, 03 medical and health sciences, N-terminal telopeptide, Internal medicine, Genetics, medicine, Vitamin D and neurology, Humans, Bone Resorption, Molecular Biology, 030304 developmental biology, business.industry, Cell Biology, medicine.disease, Vitamin D Deficiency, Diet, Calcium, business
Abstract

Skeletal remodelling is a continuous process during life and is still active also in extreme senescence. In the elderly, bone resorption often prevails over bone formation, causing bone loss and fragility. Elderly subjects are exposed to the risk of fractures, and loss of self-sufficiency, if considering that the proximal femur is the most frequently involved site. Bone remodelling can maintain circulating calcium within physiological ranges, at the expense of a substantial loss of this ion from the skeleton, particularly during senescence. Calcium metabolism is regulated at cellular/molecular level by a network of cytokines, growth factors, systemic hormones that act on bone in paracrine/autocrine/systemic fashion. Among the molecules involved in bone metabolism, parathyroid hormone (PTH) and vitamin D present some peculiar aspects during senescence. The osteometabolic features in a consistent group of centenarians have been evaluated. It results that a severe hypovitaminosis D was present in 99 out of 104 centenarians (25-OH vitamin D below 5 nmol/L), and that it plays an important role as a factor inducing a vicious circle involving hypocalcemia, secondary hyperparathyroidism, together with biochemical features indicating a consistent bone loss. Serum C-terminal cross-linking telopeptide, a specific marker of bone resorption was elevated in 92% of these subjects. Moreover, it has been found that several femoral fractures had occurred after 90 years of age. These data offer a rational for the possible prevention of elevated bone turnover, bone loss and consequently the reduction of osteoporotic fractures and fractures-induced disability, in the oldest olds, through the simple supplementation with calcium and vitamin D.

Published
2007

23. Assessment of sense of taste in Italian centenarians

Author

Baggio, G., Dalla Vestra, M., Donazzan, S., Barbagallo Sangiorgi, G., Barbagallo, M., Frada, G., Bertolini, S., Agretti, M., Costelli, P., Bosi, E., Manzoni, M., Tomasello, F. B., Capurso, A., Colacicco, A. M., Solfrizzi, V., Fabris, F., Cappa, G., Ferrario, E., Forconi, S., Guerrini, M., Boschi, S., Franceschi, C., Cossarizza, A., Monti, D., Gaddi, A., D'Addato, S., Galletti, C., Giarelli, L., Cavalieri, F., Stanta, G., Mari, D., Duca, F., Ferrazzi, P., Marigliano, V., Bauco, C., Cacciafesta, M., Masotti, G., Marchionni, N., Petruzzi, E., Mattace, R., Motta, M., Pansini, L., Motta, L., Rapisarda, R., Receputo, G., Passeri, M., Fagnoni, F., Sansoni, P., Salvioli, G., Baldelli, M. V., Neri, M., Senin, U., Cherubini, A., Polidori, M. C., Trabucchi, M., Boffelli, S., Rozzini, R., Varricchio, M., Gambardella, A., and Paolisso, G.

Subjects
Aging, medicine.medical_specialty, Study groups, Taste, Health (social science), Mini–Mental State Examination, medicine.diagnostic_test, business.industry, Sense of taste, Mean age, Audiology, Control subjects, Centenarians, Elderly, medicine, Wine tasting, Geriatrics and Gerontology, business, Gerontology
Abstract

The Italian multicentric study on centenarians (IMSC) was aimed at assessing the level of preservation of the sense of taste, and at estimating to what extent the recognition of various gustative stimuli can give satisfaction and information regarding the surrounding environment for the centenarians. Taste sensitivity has been qualitatively established in a group of 126 Italian centenarians (mean age 101.9+/-1.4 years) and compared to that of a group of 100 elderly subjects (mean age 70.5+/-5.0 years). All the individuals included in the study groups had a mini mental state examination (MMSE) score larger than 19. The results revealed that taste sensitivity is significantly reduced in the centenarians; as a matter of fact, the elderly control subjects are able to perceive taste stimuli in 84.25+/-3.40% of the testing, while the centenarians were successful only in 74.23+/-6.19% of the experiments (P

Published
1998

26. Cancer prevalence and mortality in centenarians: A systematic review

Author

Pavlidis, Nicholas, Stanta, G., Audisio, R. A., N., Pavlidi, Stanta, Giorgio, R., Audisio, and Pavlidis, Nicholas [0000-0002-2195-9961]

Subjects
Male, Oncology, Aging, Pathology, Cancer localization, Life expectancy, Cancer, Cause of death, Centenarians, Incidence, Mortality, Autopsy, Review, Disease, Metastasis, Neoplasms, 80 and over, Prevalence, Medicine, Registries, Risk assessment, Cause of death, Cancer, Aged, 80 and over, education.field_of_study, Population risk, Incidence (epidemiology), Incidence, Hematology, Cancer registry, Health survey, Multiple cancer, Female, Age distribution, Human, Adult, medicine.medical_specialty, Population, Major clinical study, Cancer research, Cancer mortality, Primary tumor, Cancer epidemiology, Life Expectancy, Internal medicine, Centenarians, Humans, Mortality, education, Cancer prevalence, Aged, business.industry, Very elderly, Sex difference, medicine.disease, Systematic review, business, Controlled study, Cancer incidence, Vital statistics
Abstract

Life expectancy has dramatically expanded, the global population has aged unprecedentedly and the number of centenarians has significantly increased. The analysis of autopsy series, cancer registries data, vital statistics and surveys specific to this age group allows unique observations with respect to incidence and prevalence, cause of death by cancer, frequency of primary tumours, metastatic patterns, occurrence of incidental cancers and of multiple primary tumours.Data analysis demonstrates how cancer incidence and cause of death present a threefold decrease after age 90 and reach 0-4% above age 100. In addition, the number of metastatic sites are remarkably less and incidental malignant tumours or multiple primary cancers are more frequent, indicating that cancer in centenarians carries a more indolent behaviour.The unique features of malignant tumours in this population is hereby presented and discussed following a systematic review of the available literature.Cancer in the very elderly is relatively uncommon as a disease and as a cause of death. It is characterized by a slow growth and a modest life-threatening potential. © 2011 Elsevier Ireland Ltd. 83 1 145 152

Published
2012

28. The role of the pathologist in tissue banking: European Consensus Expert Group Report

Author

Bevilacqua, G., Bosman, F., Dassesse, T., Höfler, H., Janin, A., Langer, R., Larsimont, D., Morente, M.M., Riegman, P., Schirmacher, P., Stanta, G., Zatloukal, K., Caboux, E., and Hainaut, P.

Subjects
Europe, Guidelines as Topic, Health Planning Guidelines, Humans, Pathology/standards, Tissue Banks/standards
Abstract

Human tissue biobanking encompasses a wide range of activities and study designs and is critical for application of a wide range of new technologies (-"omics") to the discovery of molecular patterns of disease and for implementation of novel biomarkers into clinical trials. Pathology is the cornerstone of hospital-based tissue biobanking. Pathologists not only provide essential information identifying the specimen but also make decisions on what should be biobanked, making sure that the timing of all operations is consistent with both the requirements of clinical diagnosis and the optimal preservation of biological products. This document summarizes the conclusions of a Pathology Expert Group Meeting within the European Biological and Biomolecular Research Infrastructure (BBMRI) Program. These recommendations are aimed at providing guidance for pathologists as well as for institutions hosting biobanks on how to better integrate and support pathological activities within the framework of biobanks that fulfill international standards.

Published
2010

30. Report from the OECI Oncology days 2014

Author

Harten, W.H. (Willem H) van, Stanta, G., Bussolati, G., Riegman, P.H.J. (Peter), Hoefler, G., Becker, K.-F. (Karl-Friedrich), Folprecht, G. (Gunnar), Truini, M., Haybaeck, J., Buiga, R., Dono, M., Bagg, A., Guerrero, J.A.L. (J.A. López), Zupo, S., Lemare, F., Lorenzo, F., Goedbloed, N., Razavi, D., Lövey, J., Cadariu, P.A., Rollandi, G.A., Paparo, F., Pierotti, M. (Marco Alessandro), Ciuleanu, T., De Paoli, P., Weiner, G., Saghatchian, M., Lombardo, C. (Claudio), Harten, W.H. (Willem H) van, Stanta, G., Bussolati, G., Riegman, P.H.J. (Peter), Hoefler, G., Becker, K.-F. (Karl-Friedrich), Folprecht, G. (Gunnar), Truini, M., Haybaeck, J., Buiga, R., Dono, M., Bagg, A., Guerrero, J.A.L. (J.A. López), Zupo, S., Lemare, F., Lorenzo, F., Goedbloed, N., Razavi, D., Lövey, J., Cadariu, P.A., Rollandi, G.A., Paparo, F., Pierotti, M. (Marco Alessandro), Ciuleanu, T., De Paoli, P., Weiner, G., Saghatchian, M., and Lombardo, C. (Claudio)

Abstract

The 2014 OECI Oncology Days was held at the 'Prof. Dr. Ion Chiricuta' Oncology Institute in Cluj, Romania, from 12 to 13 June. The focus of this year's gathering was on developments in personalised medicine and other treatment advances which have made the cost of cancer care too high for many regions throughout Europe.

Published
2014
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31. Report from the OECI Oncology days 2014

Author

Van Harten, W. H., Stanta, G., Bussolati, G., Riegman, P., Hoefler, G., Becker, K. F., Folprecht, G., Truini, M., Haybaeck, J., Buiga, R., Dono, M., Bagg, A., Guerrero, J. A.López, Zupo, S., Lemare, F., Lorenzo, F., Goedbloed, N., Razavi, D., Lövey, J., Cadariu, P. A., Rollandi, G. A., Paparo, F., Pierotti, M., Ciuleanu, T., De Paoli, P., Weiner, G., Saghatchian, M., Lombardo, Claudio, Van Harten, W. H., Stanta, G., Bussolati, G., Riegman, P., Hoefler, G., Becker, K. F., Folprecht, G., Truini, M., Haybaeck, J., Buiga, R., Dono, M., Bagg, A., Guerrero, J. A.López, Zupo, S., Lemare, F., Lorenzo, F., Goedbloed, N., Razavi, D., Lövey, J., Cadariu, P. A., Rollandi, G. A., Paparo, F., Pierotti, M., Ciuleanu, T., De Paoli, P., Weiner, G., Saghatchian, M., and Lombardo, Claudio

Abstract

The 2014 OECI Oncology Days was held at the 'Prof. Dr. Ion Chiricuta' Oncology Institute in Cluj, Romania, from 12 to 13 June. The focus of this year's gathering was on developments in personalised medicine and other treatment advances which have made the cost of cancer care too high for many regions throughout Europe.

Published
2014

45. Inhibition of GSK3B Bypass Drug Resistance of p53-null Colon Carcinomas by Enabling Necroptosis in Response to Chemotherapy

Author

Grassilli, E, Narloch, R, Federzoni, E, Ianzano, L, Pisano, F, Giovannoni, R, Romano, G, Masiero, L, Leone, B, Bonin, S, Donada, M, Stanta, G, Helin, K, Lavitrano, M, GRASSILLI, EMANUELA, NARLOCH, ROBERT, IANZANO, LEONARDA, GIOVANNONI, ROBERTO, ROMANO, GABRIELE, MASIERO, LAURA, LEONE, BIAGIO EUGENIO, LAVITRANO, MARIALUISA, Grassilli, E, Narloch, R, Federzoni, E, Ianzano, L, Pisano, F, Giovannoni, R, Romano, G, Masiero, L, Leone, B, Bonin, S, Donada, M, Stanta, G, Helin, K, Lavitrano, M, GRASSILLI, EMANUELA, NARLOCH, ROBERT, IANZANO, LEONARDA, GIOVANNONI, ROBERTO, ROMANO, GABRIELE, MASIERO, LAURA, LEONE, BIAGIO EUGENIO, and LAVITRANO, MARIALUISA

Abstract

PURPOSE: Evasion from chemotherapy-induced apoptosis due to p53 loss strongly contributes to drug resistance. Identification of specific targets for the treatment of drug-resistant p53-null tumors would therefore increase the effectiveness of cancer therapy EXPERIMENTAL DESIGN: By using a kinase-directed shRNA library and HCT116p53KO drug-resistant colon carcinoma cells, Glycogen Synthase Kinase 3 beta (GSK3B) was identified as a target whose silencing bypasses drug resistance due to loss of p53. p53-null colon cancer cell lines with different sets of mutations were used to validate the role of GSK3B in sustaining resistance and to characterize cell death mechanisms triggered by chemotherapy when GSK3B is silenced. In vivo xenograft studies were performed to confirm re-sensitization of drug-resistant cells to chemotherapy upon GSK3 inhibition. Colon cancer samples from a cohort of 50 chemotherapy-treated stage II patients were analyzed for active GSK3B expression RESULTS: Downregulation of GSK3B in various drug-resistant p53-null colon cancer cell lines abolished cell viability and colony growth after drug addition without affecting cell proliferation or cell cycle in untreated cells. Cell death of 5-fluorouracil (5FU)-treated p53-null GSK3B-silenced colon carcinoma cells occurred by PARP1-dependent and AIF-mediated but RIP1-independent necroptosis. In vivo studies showed that drug-resistant xenograft tumor mass was significantly reduced only when 5FU was given after GSK3B inhibition. Tissue microarray analysis of colon carcinoma samples from 5FU-treated patients revealed that GSK3B is significantly more activated in drug-resistant vs responsive patients. CONCLUSIONS: Targeting GSK3B, in combination with chemotherapy, may represent a novel strategy for the treatment of chemotherapy-resistant tumors.

Published
2013

49. Non-Hodgkin lymphoma among young adults with and without aids in Italy

Author

DAL MASO, L, Rezza, G, Zambon, P, Tagliabue, G, Crocetti, E, Vercelli, M, Zanetti, R, Falcini, F, Tonini, G, Mangone, L, DE LISI, V, Ferretti, Stefano, Tumino, R, Stanta, G, Vitarelli, S, Serraino, D, Franceschi, S, and CA CANC AIDS REGISTRY LINKAGE STUDY

Published
2001

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