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Background: Though the importance of physician non-technical (NT) skills for safe patient care is recognized, NT skills of medical students, our future physicians, has received little attention. This study aims to investigate the relationship of medical student NT skills and clinical performance during acute care team simulation (ACTS)., Methods: Forty-one medical students participated in ACTS. A nurse confederate facilitated and evaluated clinical performance. Two raters assessed participants' NT skills using an adapted NT assessment tool and overall NT skills score was calculated. Regressions predicting clinical performance using NT constructs were conducted., Results: Overall NT skills score significantly predicted students' clinical performance (r 2  = 0.178, p = 0.006). Four of the five individual NT constructs also significantly predicted performance: communication (r 2  = 0.120, p = 0.027), situation awareness (r 2  = 0.323, p < 0.001), leadership (r 2  = 0.133, p = 0.019), and decision making (r 2  = 0.163, p = 0.009)., Conclusions: Medical student NT skills can predict clinical performance during ACTS. NT skills assessments can be used for targeted education for better feedback to students., (Copyright © 2018 Elsevier Inc. All rights reserved.)