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138 results on '"Starosta, Radosław"'

7. Enhanced selectivity towards melanoma cells with zinc(II)-Schiff bases containing imidazole derivatives.

Author

Côrte-Real, Leonor, Sergi, Baris, Yildirim, Busra, Colucas, Raquel, Starosta, Radosław, Fontrodona, Xavier, Romero, Isabel, André, VÃnia, Acilan, Ceyda, and Correia, Isabel

Subjects
SCHIFF bases, DOUBLE-strand DNA breaks, TRIPLE-negative breast cancer, COORDINATION polymers, MELANOMA, ZINC, CANCER cells, IMIDAZOLES
Abstract

Zinc(II)-complexes with the general formula [Zn(L)2] containing 8-hydroxyquinoline Schiff bases functionalized with 1-(3-aminopropyl)imidazole or 1-(3-aminopropyl)-2-methyl-1H-imidazole on 2-position and their respective ligands (HL1 or HL2) were synthesized and characterized by NMR, UV-Vis, FTIR and CD spectroscopies as well as ESI-MS spectrometry. Single crystals of HL2 and [Zn(L1)2]n were analysed by SC-XRD. [Zn(L1)2]n shows a 1D polymeric chain structure of alternating Zn(II) cations and bridging Schiff base ligands, in contrast to previously reported monomeric structures of analogous complexes. DFT calculations were performed to rationalize the polymeric X-ray structure of Zn(L1)2. Results showed that the ligands can bind as bi- or tridentate to Zn(II) and there is the possibility of a dynamic behavior for the complexes in solution. Both ligands and complexes present limited stability in aqueous media, however, in the presence of bovine serum albumin the complexes are stable. Molecular docking simulations and circular dichroism spectroscopic studies suggest binding to this protein in close proximity to the Trp213 residue. Biological studies on a panel of cancer cells revealed that the Zn(II)-complexes have a lower impact on cell viability than cisplatin, except for triple-negative breast cancer cells in which they were comparable. Notwithstanding, they display much higher selectivity towards cancer cells vs. normal cells, than cisplatin. They induce the generation of ROS and DNA double-strand breaks, primarily through apoptosis as the mode of cell death. Overall, the novel Zn(II)-complexes demonstrate improved induction of apoptosis and higher selectivity, particularly for melanoma cells, compared to previously reported analogues, making them promising candidates for clinical application. [ABSTRACT FROM AUTHOR]

Published
2024
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32. New anticandidal Cu(i) complexes with neocuproine and ketoconazole derived diphenyl(aminomethyl)phosphane: luminescence properties for detection in fungal cells

Author

Starosta, Radosław, primary, de Almeida, Rodrigo F. M., additional, Puchalska, Małgorzata, additional, Białońska, Agata, additional, Panek, Jarosław J., additional, Jezierska, Aneta, additional, Szmigiel, Ida, additional, Suchodolski, Jakub, additional, and Krasowska, Anna, additional

Published
2020
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34. Unexpected formation of $[Ru(\eta^5-C_5H_5)(PH\{ CH_2N(CH_2CH_2)_2O\} _2)(PPh_3)_2]BF_4$ : the first 'piano-stool' ruthenium complex bearing a secondary aminomethylphosphane ligand

Author

Płotek, Michał, Starosta, Radosław, Komarnicka, Urszula K., Skórska-Stania, Agnieszka, Stochel, Grażyna, Kyzioł, Agnieszka, and Jeżowska-Bojczuk, Małgorzata

Abstract

In this paper we report the reaction of $[Ru(\eta^5-C_5H_5)Cl(PPh_3)_2]$ with $P\{CH_2N(CH_2CH_2)_2O\}_3$ in the presence of $NaBF_4$, in which, apart from the $Cl^{-}$ substitution, an unexpected P–C bond cleavage in the tertiary phosphane is observed. It results in the formation of $[Ru(\eta^5-C_5H_5)(PH\{ CH_2N(CH_2CH_2)_2O\} _2)(PPh_3)_2]BF_4$ (1) – the first “piano-stool” ruthenium complex with a secondary aminomethylphosphane ligand.

Published
2015

39. Copper(I) (Pseudo)Halide Complexes with Neocuproine and Aminomethylphosphines Derived from Morpholine and Thiomorpholine -In VitroCytotoxic and Antimicrobial Activity and the Interactions with DNA and Serum Albumins

Author

Starosta, Radosław, primary, Bykowska, Aleksandra, additional, Kyzioł, Agnieszka, additional, Płotek, Michał, additional, Florek, Magdalena, additional, Król, Jarosław, additional, and Jeżowska-Bojczuk, Małgorzata, additional

Published
2013
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49. Copper( I) (Pseudo)Halide Complexes with Neocuproine and Aminomethylphosphines Derived from Morpholine and Thiomorpholine - In Vitro Cytotoxic and Antimicrobial Activity and the Interactions with DNA and Serum Albumins.

Author

Starosta, Radosław, Bykowska, Aleksandra, Kyzioł, Agnieszka, Płotek, Michał, Florek, Magdalena, Król, Jarosław, and Jeżowska ‐ Bojczuk, Małgorzata

Subjects
*PHENANTHROLINE derivatives, *MORPHOLINE, *CARCINOMA, *LABORATORY mice, *CELL lines, *CANDIDA albicans
Abstract

Herein, a series of Cu I or Cu NCS complexes with neocuproine (2,9-dimethyl-1,10-phenanthroline: dmp) and two tris(aminomethyl)phosphines derived from morpholine ( P( CH2 N( CH2 CH2)2 O)3) or thiomorpholine ( P( CH2 N( CH2 CH2)2 S)3) were tested as cytotoxic agents in vitro towards mouse colon carcinoma ( CT26) and human lung adenocarcinoma ( A549). The studies showed that the complexes exhibit potential antitumor properties, displayed by IC50 values below 10 μ m towards the tested cell lines, in the case of 4-h incubation time with the examined compounds. Moreover, a high antimicrobial activity of all the complexes was observed against Staphylococcus aureus and Candida albicans with minimal inhibitory concentrations equal to 1-2 μg/mL. To gain insight into the molecular mechanism of biological activity of the complexes, we investigated also their interactions with plasmid DNA (p UC18) and the human and bovine serum albumins. Gel electrophoresis experiments demonstrated that all the compounds were comparably efficient in DNA degradation process; however, luminescence quenching showed surprising dependence on the interactions strength of the used compounds with the albumins. Apart from exceptionally effective [ CuI(dmp) P( CH2 N( CH2 CH2)2 O)3], the complexes with P( CH2 N( CH2 CH2)2 O)3 quenched more strongly luminescence of bovine serum albumin, while the complexes with P( CH2 N( CH2 CH2)2 S)3 were more active in the quenching of human serum albumin luminescence. [ABSTRACT FROM AUTHOR]

Published
2013
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