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1. Tuberculosis and Autoimmunity: Well-Coordinated Duo

Author

Yablonskiy, Piotr K., primary, Belyaeva, Irina V., additional, Churilov, Leonid P., additional, Erman, Mikhail V., additional, Kudryavtsev, Igor V., additional, Malkova, Аnna M., additional, Nikolaev, Alexei V., additional, Starshinova, Anna A., additional, and Zinchenko, Yulia S., additional

Published
2024
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2. Contributors

Author

Abu-Shakra, Mahmoud, primary, Adiguzel, Yekbun, additional, Al Shawaf, Maisam, additional, Alghory, Amal, additional, Almeida, Isabel, additional, Alrais, Mahmoud, additional, Alrifaai, Mohamad Aosama, additional, Alwani, Abdulkarim, additional, Alwani, Abdulrahman, additional, Amital, Howard, additional, Anna, Dubaniewicz, additional, Arleevskaya, Marina, additional, Ashkenazi, Shai, additional, Athanassiou, Lambros, additional, Athanassiou, Panagiotis, additional, Atik, Houda, additional, Atzeni, Fabiola, additional, Balbir-Gurman, Alexandra, additional, Balcioglu, Zeynep Betul, additional, Baldini, Chiara, additional, Barbour, Mohammad, additional, Bashi, Tomer, additional, Belyaeva, Irina V., additional, Ben-Ami, Dana, additional, Blank, Miri, additional, Boccassini, Laura, additional, Bogdanos, Dimitrios P., additional, Bombardieri, Stefano, additional, Bost, Chloé, additional, Brandão, Mariana, additional, Braun-Moscovici, Yolanda, additional, Brooks, Wesley H., additional, Campar, A., additional, Carvalheiras, Graziela, additional, Cervera, R., additional, Churilov, Leonid P., additional, Cohen, Eytan, additional, Correia, J., additional, Darkhabani, Mohammad, additional, David, Paula, additional, de Carvalho, Jozélio Freire, additional, Deniz, Omer Faruk, additional, Detrick, Barbara, additional, Deutsch, Melanie, additional, Di Battista, Marco, additional, Dogan, Emir, additional, Dogru, Omer Faruk, additional, Domingues, Vital Da Silva, additional, Dotan, Arad, additional, Dow, Coad Thomas, additional, Durai, Malarvizhi, additional, Elefante, Elena, additional, Elsalti, Abdulrahman, additional, Erman, Mikhail V., additional, Esirgun, Sevval Nil, additional, Ferrão, C., additional, Ferreira, Álvaro, additional, Ferro, Francesco, additional, Fonseca, Tomás, additional, Garg, Ravindra Kumar, additional, Guilherme, Luiza, additional, Habra, Mona, additional, Halpert, Gilad, additional, Hammerstad, Sara Salehi, additional, Hooks, John J., additional, Ilchovska, Daisy, additional, Invernizzi, Pietro, additional, Israeli, E., additional, Janket, Sok-Ja, additional, Kalil, Jorge, additional, Karaoglan, Birnur Sinem, additional, Kiyak, Zeynep, additional, Kol, Mustafa Yusuf, additional, Kostoglou-Athanassiou, Ifigenia, additional, Krause, Ilan, additional, Kudryavtsev, Igor V., additional, Kumar, Neeraj, additional, Lavine, Noy, additional, Lerman, Tsahi T., additional, Levi, Assi, additional, Ling, Eduard, additional, Moutsopoulos, Haralampos M., additional, Mahajna, Hussein, additional, Mahroum, Naim, additional, Malhotra, Hardeep Singh, additional, Malkova, Аnna M., additional, Maoz-Segal, Ramit, additional, Marinho, António, additional, Mavragani, Clio P., additional, Meurman, Jukka H., additional, Milhes, Jean, additional, Mimouni, Daniel, additional, Morais, Cátia Iracema, additional, Moudgil, Kamal D., additional, Muniz Caldas, Cezar Augusto, additional, Neves, Esmeralda, additional, Neyestani, Kamyar, additional, Nikolaev, Alexei V., additional, Noversa de Sousa, Rita, additional, Ohayon, Aviran, additional, Palumbo, Antonino, additional, Pasoto, Sandra Gofinet, additional, Petríková, Jana, additional, Puxeddu, Ilaria, additional, Raftopoulou, Sylvia, additional, Renaudineau, Yves, additional, Ribeiro, Francinne Machado, additional, Rigopoulou, Eirini I., additional, Rosário, Cristina, additional, Rossa, Alessandra Della, additional, Sahin, Meyha, additional, Sarzi-Puttini, Piercarlo, additional, Seguro, Luciana Parente Costa, additional, Seida, Isa, additional, Seida, Ravend, additional, Serpa Pinto, L., additional, Sharon, Eran, additional, Shoenfeld, Yehuda, additional, Smyk, Daniel S., additional, Sousa, Rita Catarina Medeiros, additional, Starshinova, Anna A., additional, Tamimi, Faleh, additional, Tocut, Milena, additional, Tomer, Yaron, additional, Tunitsky-Lifshitz, Yulia, additional, Vasconcelos, Carlos, additional, Vasconcelos, Júlia, additional, Vassilopoulos, Dimitrios, additional, Venkatesha, Shivaprasad H., additional, Villanueva, Ronald, additional, Vita, Pedro, additional, Yablonskiy, Piotr K., additional, Yilmaz, Mesut, additional, Zamorano, Bryan, additional, Zandman-Goddard, Gisele, additional, Zinchenko, Yulia S., additional, and Zoubi, Magdi, additional

Published
2024
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5. Tuberculosis disease in immunocompromised children and adolescents: a pTBnet multi-centre case-control study

Author

Rodríguez-Molino, Paula, primary, Tebruegge, Marc, additional, Noguera-Julian, Antoni, additional, Neth, Olaf, additional, Fidler, Katy, additional, Brinkmann, Folke, additional, Sainz, Talia, additional, Ivaskeviciene, Inga, additional, Ritz, Nicole, additional, Brito, Maria Joao, additional, Milheiro Silva, Tiago, additional, Chechenieva, Vira, additional, Serdiuk, Maryna, additional, Lancella, Laura, additional, Russo, Cristina, additional, Soler-García, Aleix, additional, Navarro, Maria Luisa, additional, Krueger, Renate, additional, Feiterna-Sperling, Cornelia, additional, Starshinova, Anna, additional, Hiteva, Antonina, additional, Hoffmann, Anna, additional, Kalibatas, Paulius, additional, Lo Vecchio, Andrea, additional, Scarano, Sara Maria, additional, Bustillo, Matilde, additional, Blázquez Gamero, Daniel, additional, Espiau, María, additional, Buonsenso, Danilo, additional, Falcón, Lola, additional, Turnbull, Louise, additional, Colino, Elena, additional, Rueda, Santiago, additional, Buxbaum, Charlotte, additional, Carazo, Begoña, additional, Alvarez, Cristina, additional, Dapena, Marta, additional, Piqueras, Anabel, additional, Velizarova, Svetlana, additional, Ozere, Iveta, additional, Götzinger, Florian, additional, Pareja, Marta, additional, Garrote Llanos, Maria Isabel, additional, Soto, Beatriz, additional, Rodríguez Martín, Sonia, additional, Korta, Jose Javier, additional, Pérez-Gorricho, Beatriz, additional, Herranz, Mercedes, additional, Hernández-Bartolomé, Ángel, additional, Díaz-Almirón, Mariana, additional, Kohns Vasconcelos, Malte, additional, Ferreras-Antolín, Laura, additional, and Santiago-García, Begoña, additional

Published
2024
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6. Tuberculosis Disease in Immunocompromised Children and Adolescents: A Pediatric Tuberculosis Network European Trials Group Multicenter Case-control Study.

Author

Rodríguez-Molino, Paula, Tebruegge, Marc, Noguera-Julian, Antoni, Neth, Olaf, Fidler, Katy, Brinkmann, Folke, Sainz, Talia, Ivaskeviciene, Inga, Ritz, Nicole, Brito, Maria Joao, Silva, Tiago Milheiro, Chechenieva, Vira, Serdiuk, Maryna, Lancella, Laura, Russo, Cristina, Soler-García, Aleix, Navarro, Maria Luisa, Krueger, Renate, Feiterna-Sperling, Cornelia, and Starshinova, Anna

Subjects
TUBERCULOSIS diagnosis, PREVENTION of communicable diseases, TUBERCULOSIS epidemiology, HIV infection complications, RISK assessment, DISEASE duration, RESEARCH funding, IMMUNOCOMPROMISED patients, TREATMENT effectiveness, DESCRIPTIVE statistics, ANTITUBERCULAR agents, PEDIATRICS, ODDS ratio, RESEARCH, CASE-control method, TUBERCULIN test, CONFIDENCE intervals, TUBERCULOSIS, IMMUNOSUPPRESSION, ADOLESCENCE, CHILDREN
Abstract

Background In high-resource settings, the survival of children with immunocompromise (IC) has increased and immunosuppressive therapies are increasingly being used. This study aimed to determine the clinical characteristics, performance of diagnostic tools, and outcome of IC children with tuberculosis (TB) in Europe. Methods Multicenter, matched case-control study within the Pediatric Tuberculosis Network European Trials Group, capturing TB cases <18 years diagnosed 2000–2020. Results A total of 417 TB cases were included, comprising 139 children who are IC (human immunodeficiency virus, inborn errors of immunity, drug-induced immunosuppression, and other immunocompromising conditions) and 278 non-IC children as controls. Nonrespiratory TB was more frequent among cases than controls (32.4% vs 21.2%; P =.013). Patients with IC had an increased likelihood of presenting with severe disease (57.6% vs 38.5%; P <.001; odds ratio [95% confidence interval], 2.073 [1.37–3.13]). Children with IC had higher rates of false-negative tuberculin skin test (31.9% vs 6.0%; P <.001) and QuantiFERON-TB Gold assay (30.0% vs 7.3%; P <.001) results at diagnosis. Overall, the microbiological confirmation rate was similar in IC and non-IC cases (58.3% vs 49.3%; P =.083). Although the mortality in children with IC was <1%, the rate of long-term sequelae was significantly higher than in non-IC cases (14.8% vs 6.1%; P =.004). Conclusions Children with IC and TB in Europe have increased rates of nonrespiratory TB, severe disease, and long-term sequelae. Immune-based TB tests have poor sensitivity in those children. Future research should focus on developing improved immunological TB tests that perform better in patients with IC, and determining the reasons for the increased risk of long-term sequelae, with the aim to design preventive management strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Vitamin D Metabolism Parameters and Cytokine Profile in COVID-19 Patients with Bolus Cholecalciferol Supplementation.

Author

Karonova, Tatiana L., Mikhaylova, Arina A., Golovatyuk, Ksenia A., Chernikova, Alena T., Korobova, Zoia R., Liubimova, Natalia E., Starshinova, Anna A., Kudlay, Dmitry A., Totolian, Areg A., and Shlyakhto, Evgeny V.

Subjects
COVID-19, VITAMIN D metabolism, VITAMIN D deficiency, VITAMIN D, DIETARY supplements
Abstract

Recent studies have demonstrated the relationship between vitamin D deficiency, infection severity and mortality from COVID-19. This study aimed to analyze the vitamin D metabolites and cytokine expression levels of COVID-19 patients who were hospitalized with bolus cholecalciferol supplementation. Materials and methods: This study represents the next stage of the open-label randomized pilot conducted by the Almazov National Medical Research Centre. A total of 44 hospitalized patients, comparable in demographic, clinical, laboratory and instrumental baseline characteristics, with moderate/severe COVID-19 were included. All patients had similar doses of concomitant corticosteroid therapy. Twenty-two patients received 50,000 IU cholecalciferol on the first and eighth days of hospitalization. The serum 25(OH)D, 1,25(OH)2D and 28 plasma cytokines were estimated for each group initially and on the ninth day of hospitalization. Results: Initially, there were no differences in the 1,25(OH)2D and cytokine levels in patients with vitamin D deficiency and normal 25(OH)D. Bolus cholecalciferol therapy at a total dose of 100,000 IU led to an increase in 25(OH)D levels in hospitalized patients with COVID-19, while the levels of the active metabolite (1,25(OH)2D) did not show significant differences between the groups or in its increased level over time, regardless of cholecalciferol supplementation. Furthermore, cholecalciferol supplementation at a total dose of 100,000 IU did not affect the majority of the cytokines estimated on the ninth day of hospitalization, except for the pro-inflammatory marker IL-1b, the concentration of which was lower in the group of patients without vitamin D supplementation. Conclusions: The 25(OH)D level was positively associated with an anti-inflammatory immune response, but cholecalciferol supplementation at a total dose of 100,000 IU did not affect the active-form vitamin D or cytokine expression levels. This fact may be explained by the impact of corticosteroid therapy, and it requires further investigation in a post-COVID-19 context. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Are Endomyocardial Ventricular Biopsies Useful for Assessing Myocardial Fibrosis?

Author

Makarov, Igor, Voronkina, Daria, Gurshchenkov, Alexander, Ryzhkov, Anton, Starshinova, Anna, Kudlay, Dmitry, and Mitrofanova, Lubov

Subjects
FIBROSIS, MYOCARDIAL ischemia, CORONARY disease, HYPERTROPHIC cardiomyopathy, CARDIOVASCULAR diseases, HEART transplantation, HYPERTENSIVE crisis
Abstract

Myocardial fibrosis is an important factor in the progression of cardiovascular diseases. However, there is still no universal lifetime method of myocardial fibrosis assessment that has a high prognostic significance. The aim of the study was to determine the significance of ventricular endomyocardial biopsies for the assessment of myocardial fibrosis and to identify the severity of myocardial fibrosis in different cardiovascular diseases. Material and Methods: Endomyocardial biopsies (EMBs) of 20 patients with chronic lymphocytic myocarditis (CM), endomyocardial fragments obtained during septal reduction of 21 patients with hypertrophic cardiomyopathy (HCM), and 36 patients with a long history of hypertensive and ischemic heart disease (HHD + IHD) were included in the study. The control group was formed from EMBs taken on 12–14 days after heart transplantation (n = 28). Also, for one patient without clinical and morphological data for cardiovascular pathology, postmortem myocardial fragments were taken from typical EMB and septal reduction sites. The relative area of fibrosis was calculated as the ratio of the total area of collagen fibers to the area of the whole biopsy. Endocardium and subendocardial fibrosis were not included in the total biopsy area. Results: The relative fibrosis area in the EMBs in the CM patient group was 5.6 [3.3; 12.6]%, 11.1 [6.6; 15.9]% in the HHD + IHD patient group, 13.4 [8.8; 16.7]% in the HCM patient group, and 2.7 [1.5; 4.6]% in the control group. When comparing the fibrosis area of the CM patients in repeat EMBs, it was found that the fibrosis area in the first EMBs was 7.6 [4.8; 12.0]%, and in repeat EMBs, it was 5.3 [3.2; 7.6]%. No statistically significant differences were found between the primary and repeat EMBs (p = 0.15). In ROC analysis, the area of fibrosis in the myocardium of 1.1% (or lower than one) was found to be highly specific for the control group of patients compared to the study patients. Conclusions: EMB in the assessment of myocardial fibrosis has a questionable role because of the heterogeneity of fibrotic changes in the myocardium. [ABSTRACT FROM AUTHOR]

Published
2024
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12. High Risk of Heart Tumors after COVID-19

Author

Mitrofanova, Lubov, primary, Makarov, Igor, additional, Goncharova, Ekaterina, additional, Makarova, Taiana, additional, Starshinova, Anna, additional, Kudlay, Dmitry, additional, and Shlaykhto, Evgeny, additional

Published
2023
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14. Expression of Cytoskeletal Proteins (GFAP, Vimentin), Proapoptotic Protein (Caspase-3) and Protective Protein (S100) in the Epileptic Focus in Adults and Children with Drug-Resistant Temporal Lobe Epilepsy Associated with Focal Cortical Dysplasia

Author

Sitovskaya, Darya, primary, Zabrodskaya, Yulia, additional, Parshakov, Petr, additional, Sokolova, Tatyana, additional, Kudlay, Dmitry, additional, Starshinova, Anna, additional, and Samochernykh, Konstantin, additional

Published
2023
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15. A Key Role of CD8+ T Cells in Controlling of Tuberculosis Infection

Author

Kudryavtsev, Igor, primary, Zinchenko, Yulia, additional, Serebriakova, Maria, additional, Akisheva, Tatiana, additional, Rubinstein, Artem, additional, Savchenko, Andrei, additional, Borisov, Alexandr, additional, Belenjuk, Vasilij, additional, Malkova, Anna, additional, Yablonskiy, Piotr, additional, Kudlay, Dmitry, additional, and Starshinova, Anna, additional

Published
2023
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23. Circulating Regulatory T Cell Subsets in Patients with Sarcoidosis

Author

Kudryavtsev, Igor, primary, Zinchenko, Yulia, additional, Starshinova, Anna, additional, Serebriakova, Maria, additional, Malkova, Anna, additional, Akisheva, Tatiana, additional, Kudlay, Dmitriy, additional, Glushkova, Anzhela, additional, Yablonskiy, Piotr, additional, and Shoenfeld, Yehuda, additional

Published
2023
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24. Severe Course of COVID-19 and Long-COVID-19 in Children: Difficulties in Diagnosis

Author

Vasichkina, Elena, primary, Kofeynikova, Olga, additional, Fetisova, Svetlana, additional, Starshinova, Anastasia Y., additional, Sheyanova, Elizaveta, additional, Vershinina, Tatiana, additional, Ryzhkov, Anton, additional, Skripnik, Aleksey, additional, Alekseeva, Daria, additional, Nechaeva, Elizaveta, additional, Glushkova, Anzhela, additional, Kudlay, Dmitry, additional, Pervunina, Tatiana, additional, and Starshinova, Anna, additional

Published
2023
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25. Identification of autoimmune markers in pulmonary tuberculosis

Author

Starshinova, Anna, primary, Malkova, Anna, additional, Zinchenko, Yulia, additional, Kudryavtsev, Igor, additional, Serebriakova, Maria, additional, Akisheva, Tatiana, additional, Lapin, Sergey, additional, Mazing, Aleksandra, additional, Kudlay, Dmitry, additional, Glushkova, Anzhela, additional, Yablonskiy, Piotr, additional, and Shoenfeld, Yehuda, additional

Published
2023
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27. New Scenarios in Heart Transplantation and Persistency of SARS-CoV-2 (Case Report).

Author

Mitrofanova, Lubov, Makarov, Igor, Gorshkov, Andrey, Vorobeva, Olga, Simonenko, Maria, Starshinova, Anna, Kudlay, Dmitry, and Karonova, Tatiana

Subjects
HEART, HEART transplantation, SARS-CoV-2, HEART transplant recipients, TRANSPLANTATION of organs, tissues, etc., CARDIAC patients
Abstract

Heart transplantation is a treatment of choice for patients with severe heart failure. Infection transmission from a donor to a recipient remains a prominent problem in organ transplantation. However, the risk of SARS-CoV-2 transmission in nonlung organ transplantation is still unclear. In this article we presented a case of a 28-year-old pregnant woman who developed heart failure soon after recovery from a SARS-CoV-2 infection in the third trimester of gestation. In the postpartum period, the heart disease worsened and the patient required cardiac transplantation. We examined the recipient's heart and made a diagnosis of left ventricular noncompaction cardiomyopathy. Immunohistochemical analysis showed SARS-CoV-2 antigen expression in the donor's heart before transplantation, and after the transplantation, an endomyocardial biopsy was taken. Moreover, an ultrastructural assessment of the endomyocardial specimen revealed endothelial and pericyte injury and a single particle on the surface of the endothelium consistent with SARS-CoV-2 viral particles. Recent findings in the literature associated these damages with SARS-CoV-2 infection. The present study describes the rare case of SARS-CoV-2 transmission from donor to postpartum recipient through a heart transplant and demonstrates the importance of endomyocardial biopsy before and after heart transplantation. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study

Author

Buonsenso, Danilo, primary, Noguera-Julian, Antoni, additional, Moroni, Rossana, additional, Hernández-Bartolomé, Angel, additional, Fritschi, Nora, additional, Lancella, Laura, additional, Cursi, Laura, additional, Soler-Garcia, Aleix, additional, Krüger, Renate, additional, Feiterna-Sperling, Cornelia, additional, Sali, Michela, additional, Lo Vecchio, Andrea, additional, Scarano, Sara, additional, Hernanz Lobo, Alicia, additional, Espiau, Maria, additional, Soriano-Arandes, Antonio, additional, Cetin, Benhur Sirvan, additional, Brinkmann, Folke, additional, Ozere, Iveta, additional, Baquero-Artigao, Fernando, additional, Tsolia, Maria, additional, Milheiro Silva, Tiago, additional, Bustillo-Alonso, Matilde, additional, Martín Nalda, Andrea, additional, Mancini, Margherita, additional, Starshinova, Anna, additional, Ritz, Nicole, additional, Velizarova, Svetlana, additional, Ferreras-Antolín, Laura, additional, Götzinger, Florian, additional, Bilogortseva, Olga, additional, Chechenyeva, Vira, additional, Tebruegge, Marc, additional, and Santiago-García, Begoña, additional

Published
2022
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36. Molecular and Cellular Mechanisms of M. tuberculosis and SARS-CoV-2 Infections—Unexpected Similarities of Pathogenesis and What to Expect from Co-Infection

Author

Starshinova, Anna A., primary, Kudryavtsev, Igor, additional, Malkova, Anna, additional, Zinchenko, Ulia, additional, Karev, Vadim, additional, Kudlay, Dmitry, additional, Glushkova, Angela, additional, Starshinova, Anastasiya Y., additional, Dominguez, Jose, additional, Villar-Hernández, Raquel, additional, Dovgalyk, Irina, additional, and Yablonskiy, Piotr, additional

Published
2022
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37. Small Fiber Neuropathy in Sarcoidosis

Author

Gavrilova, Natalia, primary, Starshinova, Anna, additional, Zinchenko, Yulia, additional, Kudlay, Dmitry, additional, Shapkina, Valeria, additional, Malkova, Anna, additional, Belyaeva, Ekaterina, additional, Pavlova, Maria, additional, Yablonskiy, Piotr, additional, and Shoenfeld, Yehuda, additional

Published
2021
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40. Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study

Author

Buonsenso, Danilo, Noguera-Julian, Antoni, Moroni, Rossana, Hernández-Bartolomé, Angel, Fritschi, Nora, Lancella, Laura, Cursi, Laura, Soler-Garcia, Aleix, Kru¨ger, Renate, Feiterna-Sperling, Cornelia, Sali, Michela, Lo Vecchio, Andrea, Scarano, Sara, Hernanz Lobo, Alicia, Espiau, Maria, Soriano-Arandes, Antonio, Cetin, Benhur Sirvan, Brinkmann, Folke, Ozere, Iveta, Baquero-Artigao, Fernando, Tsolia, Maria, Milheiro Silva, Tiago, Bustillo-Alonso, Matilde, Martín Nalda, Andrea, Mancini, Margherita, Starshinova, Anna, Ritz, Nicole, Velizarova, Svetlana, Ferreras-Antolín, Laura, Go¨tzinger, Florian, Bilogortseva, Olga, Chechenyeva, Vira, Tebruegge, Marc, and Santiago-García, Begoña

Abstract

RationaleIn 2016, a new interferon-gamma release assay (IGRA) was introduced, QuantiFERON-TB Gold Plus (QFT-Plus), claimed to have improved sensitivity in active tuberculosis (TB).ObjectivesThis study aimed to determine the performance of QFT-Plus, compared with previous generation IGRAs and the tuberculin skin test (TST), in children with TB in Europe.MethodsMulticentre, ambispective cohort study within the Paediatric Tuberculosis Network European Trials Group (ptbnet), a dedicated paediatric TB research network comprising >300 members, capturing TB cases <18 years-of-age diagnosed between January 2009 and December 2019.Measurements and main results1001 TB cases from 16 countries were included (mean age (IQR) 5.6 (2.4–12.1) years). QFT-Plus was performed in 358, QFT Gold in-Tube (QFT-GIT) in 600, T-SPOT.TBin 58 and TST in 636 cases. The overall test sensitivities were: QFT-Plus 83.8% (95% CI 80.2% to 87.8%), QFT-GIT 85.5% (95% CI 82.7% to 88.3%), T-SPOT.TB77.6% (95% CI 66.9% to 88.3%) and TST (cut-off ≥10 mm) 83.3% (95% CI 83.3% to 86.2%). There was a trend for tests to have lower sensitivity in patients with miliary and/or central nervous system (CNS) TB (73.1%, 70.9%, 63.6% and 43.5%, respectively), and in immunocompromised patients (75.0%, 59.6%, 45.5% and 59.1%, respectively).ConclusionsThe results indicate that the latest generation IGRA assay, QFT-Plus, does not perform better than previous generation IGRAs or the TST in children with TB disease. Overall, tests performed worse in CNS and miliary TB, and in immunocompromised children. None of the tests evaluated had sufficiently high sensitivity to be used as a rule-out test in children with suspected TB.

Published
2023
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43. The autoimmune criteria of sarcoidosis

Author

Starshinova, Anna, primary, Zinchenko, Ulia, additional, Malkova, Anna, additional, Basantsova, Natalia, additional, Kudryavtsev, Igor, additional, Filatov, Michail, additional, Burdakov, Vladimir, additional, and Yablonskiy, Piotr, additional

Published
2020
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44. COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study

Author

Götzinger, Florian, primary, Santiago-García, Begoña, additional, Noguera-Julián, Antoni, additional, Lanaspa, Miguel, additional, Lancella, Laura, additional, Calò Carducci, Francesca I, additional, Gabrovska, Natalia, additional, Velizarova, Svetlana, additional, Prunk, Petra, additional, Osterman, Veronika, additional, Krivec, Uros, additional, Lo Vecchio, Andrea, additional, Shingadia, Delane, additional, Soriano-Arandes, Antoni, additional, Melendo, Susana, additional, Lanari, Marcello, additional, Pierantoni, Luca, additional, Wagner, Noémie, additional, L'Huillier, Arnaud G, additional, Heininger, Ulrich, additional, Ritz, Nicole, additional, Bandi, Srini, additional, Krajcar, Nina, additional, Roglić, Srđan, additional, Santos, Mar, additional, Christiaens, Christelle, additional, Creuven, Marine, additional, Buonsenso, Danilo, additional, Welch, Steven B, additional, Bogyi, Matthias, additional, Brinkmann, Folke, additional, Tebruegge, Marc, additional, Pfefferle, Jasmin, additional, Zacharasiewicz, Angela, additional, Berger, Angelika, additional, Berger, Roland, additional, Strenger, Volker, additional, Kohlfürst, Daniela S., additional, Zschocke, Anna, additional, Bernar, Benoît, additional, Simma, Burkhard, additional, Haberlandt, Edda, additional, Thir, Christina, additional, Biebl, Ariane, additional, Vanden Driessche, Koen, additional, Boiy, Tine, additional, Van Brusselen, Daan, additional, Bael, An, additional, Debulpaep, Sara, additional, Schelstraete, Petra, additional, Pavic, Ivan, additional, Nygaard, Ulrikka, additional, Glenthoej, Jonathan P., additional, Heilmann Jensen, Lise, additional, Lind, Ilona, additional, Tistsenko, Mihhail, additional, Uustalu, Ülle, additional, Buchtala, Laura, additional, Thee, Stephanie, additional, Kobbe, Robin, additional, Rau, Cornelius, additional, Schwerk, Nicolaus, additional, Barker, Michael, additional, Tsolia, Maria, additional, Eleftheriou, Irini, additional, Gavin, Patrick, additional, Kozdoba, Oksana, additional, Zsigmond, Borbàla, additional, Valentini, Piero, additional, Ivaškeviciene, Inga, additional, Ivaškevicius, Rimvydas, additional, Vilc, Valentina, additional, Schölvinck, Elisabeth, additional, Rojahn, Astrid, additional, Smyrnaios, Anastasios, additional, Klingenberg, Claus, additional, Carvalho, Isabel, additional, Ribeiro, Andreia, additional, Starshinova, Anna, additional, Solovic, Ivan, additional, Falcón, Lola, additional, Neth, Olaf, additional, Minguell, Laura, additional, Bustillo, Matilde, additional, Gutiérrez-Sánchez, Aida M., additional, Guarch Ibáñez, Borja, additional, Ripoll, Francesc, additional, Soto, Beatriz, additional, Kötz, Karsten, additional, Zimmermann, Petra, additional, Schmid, Hanna, additional, Zucol, Franziska, additional, Niederer, Anita, additional, Buettcher, Michael, additional, Cetin, Benhur S., additional, Bilogortseva, Olga, additional, Chechenyeva, Vera, additional, Demirjian, Alicia, additional, Shackley, Fiona, additional, McFetridge, Lynne, additional, Speirs, Lynne, additional, Doherty, Conor, additional, Jones, Laura, additional, McMaster, Paddy, additional, Murray, Clare, additional, Child, Frances, additional, Beuvink, Yvonne, additional, Makwana, Nick, additional, Whittaker, Elisabeth, additional, Williams, Amanda, additional, Fidler, Katy, additional, Bernatoniene, Jolanta, additional, Song, Rinn, additional, Oliver, Zoe, additional, and Riordan, Andrew, additional

Published
2020
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45. Prospects for the use of new generation of anti-tuberculosis drugs in treatment of drug-resistant tuberculosis

Author

Pavlova, Mariia V., primary, Vinogradova, Tatiana I., additional, Zabolotnykh, Natalia V., additional, Ershova, Elena S., additional, Sapozhnikova, Nadezhda V., additional, Chernokhaeva, Irina V., additional, Archakova, Liudmila I., additional, Vitovskaya, Mariia L., additional, Dogonadze, Marine Z., additional, Starshinova, Anna A., additional, Grishko, Alevtina N., additional, and Yablonsky, Petr K., additional

Published
2020
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46. New laboratory criterion for the differential diagnosis of sarcoidosis and pulmonary tuberculosis

Author

Starshinova, Anna, primary, Malkova, Anna, additional, Zinchenko, Yulia, additional, Basantsova, Natalia, additional, Kudryavtsev, Igor, additional, Lapin, Sergey, additional, Mazing, Alexandra, additional, Surkova, Elena, additional, Pavlova, Maria, additional, Belyaeva, Ekaterina, additional, Stepanenko, Tatiana, additional, and Yablonskiy, Piotr, additional

Published
2020
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50. Sarcoidosis as an Autoimmune Disease

Author

Starshinova, Anna A., primary, Malkova, Anna M., additional, Basantsova, Natalia Y., additional, Zinchenko, Yulia S., additional, Kudryavtsev, Igor V., additional, Ershov, Gennadiy A., additional, Soprun, Lidia A., additional, Mayevskaya, Vera A., additional, Churilov, Leonid P., additional, and Yablonskiy, Piotr K., additional

Published
2020
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