1. Insulin Resistance and Insulin-Like Growth Factors in Children with Intrauterine Growth Retardation
- Author
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Arianna Maiorana, Stefano Canfarani, Sergio Boemi, Caterina Geremia, Giuseppe Scirè, and Daniela Germani
- Subjects
medicine.medical_specialty ,Growth retardation ,business.industry ,Endocrinology, Diabetes and Metabolism ,Insulin ,medicine.medical_treatment ,medicine.disease ,Endocrinology ,Insulin resistance ,Internal medicine ,Pediatrics, Perinatology and Child Health ,medicine ,business - Abstract
Aims: To investigate (a) the prevalence of insulin resistance in children with intrauterine growth retardation (IUGR); (b) whether catch-up growth is associated with a higher risk of insulin resistance; (c) the insulin-like growth factor (IGF) system status. Methods: 49 children with IUGR aged 9.1 ± 3.3 years underwent anthropometric measurements, and assessment of insulin resistance and IGF system parameters. A fasting glucose/insulin ratio (G/I) Results: 11/49 (22%) children had a G/I Conclusions: (a) Children with IUGR have a high prevalence of reduced insulin sensitivity; (b) postnatal catch-up growth is related to intrauterine growth and actual nutritional status; (c) insulin sensitivity status is not related to postnatal growth but to liver function; (d) IGF system is normal and not related to the insulin resistance parameters during childhood.
- Published
- 2001