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1. Poor response to methylphenidate is associated with a smaller dorsal attentive network in adult Attention-Deficit/Hyperactivity Disorder (ADHD)

Author: Valeria Parlatini, Joaquim Radua, Aleix Solanes Font, Rob Wichers, Stefanos Maltezos, Masafumi Sanefuji, Flavio Dell’Acqua, Marco Catani, Michel Thiebaut de Schotten, and Declan Murphy
Subjects: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Abstract Stimulants, such as methylphenidate (MPH), are effective in treating attention-deficit/hyperactivity disorder (ADHD), but there is individual variability in response, especially in adults. To improve outcomes, we need to understand the factors associated with adult treatment response. This longitudinal study investigated whether pre-treatment anatomy of the fronto-striatal and fronto-parietal attentional networks was associated with MPH treatment response. 60 adults with ADHD underwent diffusion brain imaging before starting MPH treatment, and response was measured at two months. We tested the association between brain anatomy and treatment response by using regression-based approaches; and compared the identified anatomical characteristics with those of 20 matched neurotypical controls in secondary analyses. Finally, we explored whether combining anatomical with clinical and neuropsychological data through machine learning provided a more comprehensive profile of factors associated with treatment response. At a group level, a smaller left dorsal superior longitudinal fasciculus (SLF I), a tract responsible for the voluntary control of attention, was associated with a significantly lower probability of being responders to two-month MPH-treatment. The association between the volume of the left SLF I and treatment response was driven by improvement on both inattentive and hyperactive/impulsive symptoms. Only non-responders significantly differed from controls in this tract metric. Finally, our machine learning approach identified clinico-neuropsychological factors associated with treatment response, such as higher cognitive performance and symptom severity at baseline. These novel findings add to our understanding of the pathophysiological mechanisms underlying response to MPH, pointing to the dorsal attentive network as playing a key role.
Published: 2023
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2. Reduced inferior fronto-insular-thalamic activation during failed inhibition in young adults with combined ASD and ADHD compared to typically developing and pure disorder groups

Author: Steve Lukito, Owen G. O’Daly, David J. Lythgoe, John Hodsoll, Stefanos Maltezos, Mark Pitts, Emily Simonoff, and Katya Rubia
Subjects: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Abstract Autism spectrum disorder (ASD) often co-occurs with attention-deficit/hyperactivity disorder (ADHD) and people with these conditions have frontostriatal functional atypicality during motor inhibition. We compared the neural and neurocognitive correlates of motor inhibition and performance monitoring in young adult males with “pure” and combined presentations with age-and sex-matched typically developing controls, to explore shared or disorder-specific atypicality. Males aged 20–27 years with typical development (TD; n = 22), ASD (n = 21), combined diagnoses ASD + ADHD (n = 23), and ADHD (n = 25) were compared using a modified tracking fMRI stop-signal task that measures motor inhibition and performance monitoring while controlling for selective attention. In addition, they performed a behavioural go/no-go task outside the scanner. While groups did not differ behaviourally during successful stop trials, the ASD + ADHD group relative to other groups had underactivation in typical performance monitoring regions of bilateral anterior insula/inferior frontal gyrus, right posterior thalamus, and right middle temporal gyrus/hippocampus during failed inhibition, which was associated with increased stop-signal reaction time. In the behavioural go/no-go task, both ADHD groups, with and without ASD, had significantly lower motor inhibition performance compared to TD controls. In conclusion, only young adult males with ASD + ADHD had neurofunctional atypicality in brain regions associated with performance monitoring, while inhibition difficulties on go/no-go task performance was shared with ADHD. The suggests that young people with ASD + ADHD are most severely impaired during motor inhibition tasks compared to ASD and ADHD but do not reflect a combination of the difficulties associated with the pure disorders.
Published: 2023
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3. Comparison of an online adaptation of the Autism Diagnostic Observation Schedule-2 with its in-person version in an adult autism diagnostic service

Author: Charlotte E. Blackmore, Alexandra Nolan, Vladimira Stoencheva, Natalie Greenwood, Natasha Liu-Thwaites, Stefanos Maltezos, and Grainne M. McAlonan
Subjects: Autism spectrum disorders, autism, Autism Diagnostic Observation Schedule, diagnosis, telehealth, Psychiatry, RC435-571
Abstract: Background Restrictions on in-person assessments during the COVID-19 pandemic were a challenge for an adult autism diagnostic service receiving over 600 referrals annually. The service sought to adapt the Autism Diagnostic Observation Schedule (ADOS-2) for online administration. Aims To investigate whether an online adaptation of the ADOS-2 performed comparably to the in-person ADOS-2. To obtain qualitative feedback from patients and clinicians regarding experiences of the online alternative. Method Online ADOS-2 assessments were completed for 163 referred individuals. A matched-comparison group comprised 198 individuals seen for an in-person ADOS-2 assessment prior to COVID-19 restrictions. A two-way analysis of variance (ANOVA) was run to explore any effect of assessment type (online or in-person ADOS-2) and gender on total ADOS score. Qualitative feedback was collected from 46 patients and 8 clinicians involved in diagnostic decision-making after the online ADOS-2 assessment. Results A two-way ANOVA found no significant effect of assessment type or gender and no assessment type × gender interaction effect on total ADOS score. Qualitative feedback suggested that only 27% of patients would have preferred an in-person assessment. Nearly all clinicians reported gains from offering an online alternative. Conclusions This is the first study to examine an online adaptation of ADOS-2 within an adult autism diagnostic service. It performed comparably to the in-person ADOS-2, making it a viable alternative when in-person assessments are not possible. As this clinic group has high rates of comorbid mental health difficulties, we encourage further work to determine whether online assessment approaches generalise to other services to increase options for patients and efficiencies for service delivery.
Published: 2023
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4. The key role of daytime sleepiness in cognitive functioning of adults with attention deficit hyperactivity disorder

Author: Bartosz Helfer, Natali Bozhilova, Ruth E. Cooper, Joanna I. Douzenis, Stefanos Maltezos, and Philip Asherson
Subjects: Attention-deficit/hyperactivity disorder, adults, EEG slowing, cognition, observer-rated sleepiness, sleepiness, Psychiatry, RC435-571
Abstract: AbstractBackground.Adults with attention deficit hyperactivity disorder (ADHD) frequently suffer from sleep problems and report high levels of daytime sleepiness compared to neurotypical controls, which has detrimental effect on quality of life.Methods.We evaluated daytime sleepiness in adults with ADHD compared to neurotypical controls using an observer-rated sleepiness protocol during the Sustained Attention Response Task as well as electroencephalogram (EEG) slowing, a quantitative electroencephalographic measure collected during a short period of wakeful rest.Results.We found that adults with ADHD were significantly sleepier than neurotypical controls during the cognitive task and that this on-task sleepiness contributed to cognitive performance deficits usually attributed to symptoms of ADHD. EEG slowing predicted severity of ADHD symptoms and diagnostic status, and was also related to daytime sleepiness. Frontal EEG slowing as well as increased frontal delta were especially prominent in adults with ADHD. We have validated and adapted an objective observer-rated measure for assessing on-task sleepiness that will contribute to future sleep research in psychology and psychiatry.Conclusions.These findings indicate that the cognitive performance deficits routinely attributed to ADHD and often conceptualized as cognitive endophenotypes of ADHD are largely due to on-task sleepiness and not exclusively due to ADHD symptom severity. Daytime sleepiness plays a major role in cognitive functioning of adults with ADHD.
Published: 2020
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5. Lateralization of attention in adults with ADHD: Evidence of pseudoneglect

Author: Bartosz Helfer, Stefanos Maltezos, Elizabeth Liddle, Jonna Kuntsi, and Philip Asherson
Subjects: ADHD, arousal, attention, lateralization, reaction time, Psychiatry, RC435-571
Abstract: AbstractBackground.We investigated whether adults with attention-deficit/hyperactivity disorder (ADHD) show pseudoneglect—preferential allocation of attention to the left visual field (LVF) and a resulting slowing of mean reaction times (MRTs) in the right visual field (RVF), characteristic of neurotypical (NT) individuals —and whether lateralization of attention is modulated by presentation speed and incentives.Method.Fast Task, a four-choice reaction-time task where stimuli were presented in LVF or RVF, was used to investigate differences in MRT and reaction time variability (RTV) in adults with ADHD (n = 43) and NT adults (n = 46) between a slow/no-incentive and fast/incentive condition. In the lateralization analyses, pseudoneglect was assessed based on MRT, which was calculated separately for the LVF and RVF for each condition and each study participant.Results.Adults with ADHD had overall slower MRT and increased RTV relative to NT. MRT and RTV improved under the fast/incentive condition. Both groups showed RVF-slowing with no between-group or between-conditions differences in RVF-slowing.Conclusion.Adults with ADHD exhibited pseudoneglect, a NT pattern of lateralization of attention, which was not attenuated by presentation speed and incentives.
Published: 2020
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6. Emotion recognition and mind wandering in adults with attention deficit hyperactivity disorder or autism spectrum disorder

Author: Stefanos Maltezos, Bartosz Helfer, Sara Boxhoorn, Joanna Songa, Philip Asherson, and Charlotte Steel
Subjects: Adult, genetic structures, Autism Spectrum Disorder, media_common.quotation_subject, Emotions, Poison control, Anger, behavioral disciplines and activities, 03 medical and health sciences, Cognition, 0302 clinical medicine, mental disorders, medicine, Humans, Attention deficit hyperactivity disorder, Biological Psychiatry, media_common, fungi, medicine.disease, Emotional dysregulation, Disgust, 030227 psychiatry, Psychiatry and Mental health, Attention Deficit Disorder with Hyperactivity, Autism spectrum disorder, Psychology, Facial Recognition, 030217 neurology & neurosurgery, Neurotypical, Clinical psychology, Psychopathology
Abstract: Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in adults are often undiagnosed and overlap in psychopathology. Here we investigated the transdiagnostic traits of emotion recognition and mind wandering in a sample of 103 adults (43 with ADHD and 14 with ASD). The ability to correctly identify a facial expression of anger, fear, disgust or surprise was no different between the adults with ADHD or ASD and neurotypical (NT) adults. However, adults with ADHD or ASD were on average almost 200 ms slower in making a correct decision, suggesting a larger speed-accuracy trade-off in facial emotion recognition compared to NT adults. General processing speed was associated with excessive mind wandering in adults with ADHD, but not with ASD. The deficits in emotional processing were independent from mind wandering in both adults with ADHD or ASD. Emotional dysregulation and functional impairment scales separated adults with ADHD and ASD from the NT adults, but not from each other. When controlling for self-reported ADHD and ASD symptom severity, mind wandering in ADHD was independent from both ADHD and ASD symptom severity. In ASD, mind wandering was related to ASD but not ADHD symptom severity. Our results suggest that ASD and ADHD share a slower ability to recognize emotions, which is exacerbated by excessive mind wandering in ADHD, and by decreased processing speed in ASD.
Published: 2021

7. How Does an Observational Assessment Adapted for Online Delivery Perform Compared to an In-Person Assessment? Learning From the National Autism Service for Adults

Author: Charlotte Blackmore, Alexandra Nolan, Vladimira Stoencheva, Natalie Greenwood, Natasha Liu-Thwaites, Stefanos Maltezos, and Grainne McAlonan
Subjects: Psychiatry and Mental health
Abstract: AimsThe National Autism Service for Adults receives over 600 referrals annually and with an extensive waitlist, COVID-19 restrictions on in-person assessments were a challenge for service delivery. We aimed to adapt the Autism Diagnostic Observation Schedule (ADOS) for online delivery and investigate whether it is comparable to the in-person ADOS in predicting Autism Spectrum Disorder (ASD) diagnostic outcome. We also aimed to obtain qualitative feedback from service users and clinicians regarding experiences of the online ADOS.MethodsA working group of staff who administer ADOS and representatives from psychiatry, psychology and management reached consensus that an online version of ADOS module 4 was feasible based on experience that a lot information required for coding is obtained verbally and some tasks were adaptable for online delivery. After the pilot, it was agreed all algorithm items could be coded except ‘unusual eye-contact’. Subsequently, 163 service users attended an online ADOS between August 2020 and February 2021. A matched-comparison group consisted of 198 service users seen for an in-person ADOS between May 2014 and February 2020. Algorithm scores were recorded and ASD diagnosis was made by a trained clinician. Qualitative feedback regarding the online ADOS was collected from 46 service users and 11 clinicians.ResultsThe working group agreed the online and in-person ADOS were closely matched regarding administration and coding. Mean scores for service users who received an ASD diagnosis were comparable for the online and in-person ADOS groups (7 and 8 respectively). This was also shown for those who were not diagnosed with ASD (3 and 4 respectively). A two-sample t-test showed no significant difference in total scores between the online and in-person ADOS (p = 0.38). Qualitative feedback suggested good service user and clinician satisfaction; only 27% of service users indicated they would have preferred an in-person assessment; 88% of clinicians reported there were gains from offering an online alternative. Although the online and in-person ADOS perform similarly, clinicians reported relying more on qualitative reports over scores from the online version to inform diagnostic decision.ConclusionTo our knowledge, this is the first study to examine using an online ADOS within an adult diagnostic service. Due to its comparable performance, the online-ADOS is a viable alternative option for service delivery when in-person assessments are not possible. As this clinic group has high rates of comorbid mental health difficulties, the applicability of online assessments could generalise to other services and have an impact beyond the pandemic.
Published: 2022

8. ADHD in adults

Author: Stefanos Maltezos, Susannah Whitwell, and Philip Asherson
Subjects: mental disorders
Abstract: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by pervasive or impairing levels of inattention or hyperactivity. It is most comprehensively defined in the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) criteria, which recognizes its clinical heterogeneity by grouping it according to three presentations: predominantly inattentive, predominantly hyperactive–impulsive, and combined subtypes. However, ADHD presentations can change significantly over time, most often presenting predominantly as hyperactive–impulsive in infants, with combined symptoms for children, and predominantly inattentive in the case of adults. This chapter focuses on the presentation of ADHD in adults, discussing the detrimental effects its various presentations can have on economic, educational, and social outcomes, before examining the systemic limitations of its recognition and treatment in certain countries. Finally, management and treatment methods are explored, for instance the administering of dopamine and noradrenaline reuptake inhibitors such as methylphenidate and atomoxetine, respectively, and the lack of data on their effectiveness in tackling ADHD comorbidities such as bipolar disorder and schizophrenia.
Published: 2020

9. Lateralization of attention in adults with ADHD: Evidence of pseudoneglect

Author: Philip Asherson, Jonna Kuntsi, Elizabeth B. Liddle, Bartosz Helfer, and Stefanos Maltezos
Subjects: Adult, Male, medicine.medical_specialty, Audiology, Functional Laterality, Lateralization of brain function, Task (project management), Arousal, 03 medical and health sciences, 0302 clinical medicine, arousal, medicine, Humans, ADHD, lateralization, 11 Medical and Health Sciences, reaction time, Psychiatry, Motivation, attention, 17 Psychology and Cognitive Sciences, 030227 psychiatry, Visual field, Psychiatry and Mental health, Psychophysiology, Attention Deficit Disorder with Hyperactivity, Right visual field, Space Perception, Female, Psychology, 030217 neurology & neurosurgery, Neurotypical, Research Article
Abstract: Background. We investigated whether adults with attention-deficit/hyperactivity disorder (ADHD) show pseudoneglect—preferential allocation of attention to the left visual field (LVF) and a resulting slowing of mean reaction times (MRTs) in the right visual field (RVF), characteristic of neurotypical (NT) individuals —and whether lateralization of attention is modulated by presentation speed and incentives. Method. Fast Task, a four-choice reaction-time task where stimuli were presented in LVF or RVF, was used to investigate differences in MRT and reaction time variability (RTV) in adults with ADHD (n = 43) and NT adults (n = 46) between a slow/no-incentive and fast/incentive condition. In the lateralization analyses, pseudoneglect was assessed based on MRT, which was calculated separately for the LVF and RVF for each condition and each study participant. Results. Adults with ADHD had overall slower MRT and increased RTV relative to NT. MRT and RTV improved under the fast/incentive condition. Both groups showed RVF-slowing with no between-group or between-conditions differences in RVF-slowing. Conclusion. Adults with ADHD exhibited pseudoneglect, a NT pattern of lateralization of attention, which was not attenuated by presentation speed and incentives.
Published: 2020

10. Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans

Author: Ndabezinhle Mazibuko, Grainne M. McAlonan, Stefanos Maltezos, Yannis Paloyelis, Steven Williams, Aikaterini Fotopoulou, Uwe Schuschnig, Matthew A. Howard, Declan G. Murphy, Stephen J. Wastling, Sofia Vasilakopoulou, Mitul A. Mehta, Daniel Martins, Jack Loveridge, Fernando Zelaya, and Alice E Oates
Subjects: 0301 basic medicine, Male, medicine.medical_treatment, General Physics and Astronomy, Pharmacology, Oxytocin, Placebos, 0302 clinical medicine, Heart Rate, lcsh:Science, 0303 health sciences, Multidisciplinary, Drug discovery, intranasal, Brain, Nose to brain, Amygdala, Magnetic Resonance Imaging, 3. Good health, medicine.anatomical_structure, Cerebral blood flow, Cerebrovascular Circulation, Administration, Intravenous, Perfusion, hormones, hormone substitutes, and hormone antagonists, medicine.drug, Adult, endocrine system, Science, Systemic circulation, General Biochemistry, Genetics and Molecular Biology, Article, arterial spinal labelling, Route of administration, 03 medical and health sciences, Young Adult, Double-Blind Method, oxytocin, medicine, Humans, Administration, Intranasal, 030304 developmental biology, business.industry, Nebulizers and Vaporizers, General Chemistry, nose-to-brain transport, 030104 developmental biology, Nasal spray, intravenous, Nasal administration, lcsh:Q, business, Neuroscience, 030217 neurology & neurosurgery
Abstract: Could nose-to-brain pathways mediate the effects of peptides such as oxytocin (OT) on brain physiology when delivered intranasally? We address this question by contrasting two methods of intranasal administration (a standard nasal spray, and a nebulizer expected to improve OT deposition in nasal areas putatively involved in direct nose-to-brain transport) to intravenous administration in terms of effects on regional cerebral blood flow during two hours post-dosing. We demonstrate that OT-induced decreases in amygdala perfusion, a key hub of the OT central circuitry, are explained entirely by OT increases in systemic circulation following both intranasal and intravenous OT administration. Yet we also provide robust evidence confirming the validity of the intranasal route to target specific brain regions. Our work has important translational implications and demonstrates the need to carefully consider the method of administration in our efforts to engage specific central oxytocinergic targets for the treatment of neuropsychiatric disorders., Intranasal oxytocin can affect brain function either by direct entry to the brain or by increasing oxytocin levels in blood plasma. Here, the authors show that increases in plasmatic oxytocin account for some but not all of the changes observed following intranasal oxytocin administration.
Published: 2019
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11. The effects of emotional lability, mind wandering and sleep quality on ADHD symptom severity in adults with ADHD

Author: Natali Bozhilova, Bartosz Helfer, Stefanos Maltezos, Ruth E. Cooper, Philip Asherson, and Jonna Kuntsi
Subjects: Adult, Male, Mediation (statistics), Emotional lability, Severity of Illness Index, behavioral disciplines and activities, Life Change Events, Thinking, 03 medical and health sciences, 0302 clinical medicine, Mind-wandering, mental disorders, medicine, Humans, Attention deficit hyperactivity disorder, Adults, Affective Symptoms, Sleep Hygiene, Adhd symptoms, Psychiatric Status Rating Scales, Sleep quality, fungi, Mind wandering, Symptom severity, Sleep Latency, medicine.disease, Irritable Mood, 030227 psychiatry, Diagnostic and Statistical Manual of Mental Disorders, Poor sleep, Psychiatry and Mental health, Attention-deficit/hyperactivity disorder, Attention Deficit Disorder with Hyperactivity, Female, medicine.symptom, Psychology, 030217 neurology & neurosurgery, Clinical psychology
Abstract: Mind wandering, emotional lability and sleep quality are currently mostly independently investigated but are all interlinked and play a major role is adult attention-deficit/ hyperactivity disorder (ADHD). Emotional lability is a core feature of the disorder, excessive mind wandering has recently been linked to symptoms and impairments of ADHD and poor sleep quality is experienced by a clear majority of adults with ADHD. All three phenomena lead to functional impairment in ADHD, however their relationship to each other and to ADHD symptom severity is not well understood. Here we used serial multiple mediation models to examine the influence of mind wandering, sleep quality and emotional lability on ADHD symptom severity. 81 adults diagnosed with ADHD participated in this study. We found that mind wandering and emotional lability predicted ADHD symptom severity and that mind wandering, emotional lability and sleep quality were all linked and significantly contributed to the symptomatology of adult ADHD. Mind wandering was found to lead to emotional lability which in turn lead to ADHD symptom severity; and poor sleep quality was found to exacerbate mind wandering leading to ADHD symptoms. Future research should employ objective on-task measures of mind wandering, sleepiness and emotional lability to investigate the neural basis of these impairing deficits in ADHD.
Published: 2019

12. Measurement of $W^{\pm}Z$ production cross sections and gauge boson polarisation in $pp$ collisions at $\sqrt{s} = 13$ TeV with the ATLAS detector

Author: Luca Colasurdo, Alexander David Sherman, Manuel Patrice Geisler, A. Tarek Abouelfadl Mohamed, Jiri Hejbal, Vadim Bednyakov, Maximiliano Sioli, Marco Delmastro, Fridolin Dittus, Stefanie Morgenstern, Laurelle Maria Veloce, Ryuichi Takashima, Ettore Zaffaroni, Alexander Armstrong, Simon Schmitz, Fabian Thiele, Miao Liu, G. H. A. Viehhauser, Tomas Davidek, Sandrine Laplace, Moritz Backes, Z. Wang, M. Vranjes Milosavljevic, Marcello Bindi, Matteo Scornajenghi, Ryan Reece, Andreas Christian Dudder, Panagiotis Bellos, Petr Tas, S. H. Oh, Laura Gonella, Stefano Veneziano, Robert Reed, Michael Düren, Tobias Golling, Adam Bailey, Callum Robert Kilby, Eleni Myrto Asimakopoulou, Peter Sherwood, Pavel Starovoitov, Bernhard Meirose, Cristiano David Sebastiani, M. A. B. do Vale, A. A. Affolder, Moritz Kiehn, Forrest Hays Phillips, Paul Mircea Gravila, Sofia Chouridou, Maria-Teresa Dova, Sascha Caron, Vladimir Sulin, Grygorii Sokhrannyi, Uta Klein, Maria Smizanska, J. E. Brau, Christopher Bee, Petr Vokac, Eva Hansen, Michel Raymond, Bruce Schumm, Charles Delporte, Leonardo Merola, Madalyn Ann McKay, Akihiro Higashida, Daniel Lellouch, Konstantin Belotskiy, K. Nakamura, Aytul Adiguzel, Liaoshan Shi, S. De Cecco, Dmitri Tsybychev, K. Gellerstedt, Hannah Arnold, Christian Heinz, Antonio Sidoti, Ian Hinchliffe, Carlo Alberto Gottardo, Shikma Bressler, Mariya Shiyakova, Feng Lyu, Danilo Giugni, Otmar Biebel, Peilong Wang, Takuya Nobe, Michael Adersberger, Jelena Jovicevic, Wing Sheung Chan, Jeffrey David Shahinian, Gerjan Bobbink, Jannik Geisen, Nikolaos Konstantinidis, Sebastian Mergelmeyer, Simon Holm Stark, Shuwei Ye, Per Edvin Sidebo, Alberto Aloisio, Andrew Hard, Markus Cristinziani, Serhat Oerdek, Leszek Adamczyk, Andrea Knue, Steffen Henkelmann, P. Farthouat, Maurice Becker, Bruce Barnett, E. Rizvi, Kim Katrin Heidegger, Daniel Mauricio Rauch, M. P. Giordani, Chilufya Mwewa, M. Stegler, Dalila Salamani, Thomas LeCompte, Daniel Mori, F. M. Giorgi, B. Martin dit Latour, S. P. Mc Kee, Lorenzo Paolozzi, S. Heim, C. P. Ward, Yohei Noguchi, Tamsin Nooney, Ewan Hill, Tim Scanlon, Elizaveta Shabalina, Harry James Moss, Sanmay Ganguly, Simon Berlendis, Evgeniy Khramov, M. Rescigno, Tasneem Rashid, Grigore Tarna, Hiroshi Sakamoto, T. S. Lau, Timothy Andeen, Adam Maxwell Azoulay, Andrey Minaenko, Andrey Soukharev, Konstantin Lehmann, K. K. Gan, Stanislav Suchek, Gilberto Giugliarelli, Christian Weber, Eduard Simioni, Brian Petersen, Namig Javadov, Tamar Djobava, Claudia Merlassino, Balazs Konya, P. H. Hansen, Osamu Jinnouchi, Trygve Buanes, J. Tanaka, Y. Hernández Jiménez, Apostolos Tsirigotis, D. Levin, Karsten Köneke, E. von Toerne, Julien Caudron, Stanislav Nemecek, Marisilvia Donadelli, Hideyuki Oide, Dugan O'Neil, Stefan Rave, James Frost, Pier-Olivier Deviveiros, Jonas Strandberg, Nacim Haddad, Sinan Kuday, David Malon, Emre Celebi, R. Camacho Toro, Dimitrii Krasnopevtsev, Mariyan Petrov, Sergey Senkin, Nan Lu, Bo Liu, Veysi Erkcan Ozcan, Alberto Mengarelli, P. D. Thompson, Jonathan Long, Efe Yigitbasi, S. A. Olivares Pino, Josh Mcfayden, Andrew Pilkington, Vitaliano Chiarella, Bobby Samir Acharya, H. A. Neal, Reisaburo Tanaka, Guido Volpi, L. F. Oleiro Seabra, Adrian Chitan, Luc Goossens, Natalia Korotkova, S. Timoshenko, Daniela Rebuzzi, Bianca Osculati, Itsuo Nakano, Benjamin Wynne, A. G. Clark, Koki Maekawa, Helena Santos, Barbara Wosiek, Marc Geisen, Roland Jansky, T. Ženiš, Jyoti Prakash Biswal, Henrik Oppen, Rachid Mazini, Joyful Elma Mdhluli, D. Pohl, M. C. N. Fiolhais, Georges Aad, Robert Astalos, Emmanuel Monnier, Alexandru Hostiuc, A. De Salvo, Radek Novotny, Koji Terashi, Mark Owen, Andrey Kiryunin, Nuno Filipe Castro, Jing Wang, Juraj Bracinik, Will Davey, Maria Giulia Ratti, J. Kroll, A. Pacheco Pages, Nguyen Phuong Dang, Hidetoshi Otono, Peter Nemethy, Guillaume Unal, A. Artamonov, Carmen Maidantchik, L. Manhaes de Andrade Filho, A. P. Pereira Peixoto, Daniela Bortoletto, Nello Bruscino, Anna Kaczmarska, Timon Heim, D. Rodriguez Rodriguez, Craig Buttar, M-S. Barisits, Bertrand Laforge, Michele Livan, Harald Fox, Lashkar Kashif, Q. J. Li, Emily Nurse, Rafal Staszewski, Jakub Andrzej Kremer, Khalil Bouaouda, Liron Barak, J. R. Bensinger, Rose Elisabeth Ardell, Sophio Pataraia, M. Della Pietra, Stylianos Angelidakis, Ladislav Chytka, Annick Lleres, Osamu Sasaki, S. George, Yongsheng Gao, Mark Kruse, Alison Lister, Gino Marceca, Luigi Marchese, G. Zhang, Elizabeth Gallas, Antoine Laudrain, Dario Barberis, Mykhailo Lisovyi, Arnaud Ferrari, Robert Adam Vallance, Christopher Grud, Savannah Jennifer Thais, Nora Emilia Pettersson, Margaret Susan Lutz, A. Korn, Pietro Albicocco, Marcia Begalli, Robert J. Bielski, Evgeny Starchenko, Stefanos Maltezos, C. Padilla Aranda, Oliver Majersky, Robert Hankache, Michael William Phipps, Stefano Rosati, Suvrajeet Sen, R. Di Nardo, Tadamitsu Kishimoto, T. Kuhl, Siarhei Harkusha, Mario Sannino, Julia Isabell Djuvsland, Konrad Kleinknecht, S. Farrell, Eric Hayato Takasugi, Sune Jakobsen, Giacomo Artoni, Othmane Rifki, Jessica Metcalfe, Mathieu Benoit, Jason Dhia Mansour, Yang Li, Yuji Yamazaki, Teresa Barillari, Philipp Jonathan Lösel, C. Adam Bourdarios, Jun Su, Ren-You Zhang, Jelena Krstic, Vassili Kazanin, Michael Holzbock, Edisher Tskhadadze, Alexey Myagkov, Luc Poggioli, Marine Kuna, Nimrod Taiblum, Alexey Boldyrev, Kirill Grevtsov, Marlon Barbero, Yuji Minegishi, Zinonas Zinonos, Paul Tipton, Laura Rehnisch, Victor Kukhtin, Petr Hamal, Stefan Richter, K. Potamianos, Ljiljana Morvaj, Allen Mincer, Anatoly Kozhin, Ryan Justin Atkin, David Francis, Marcello Fanti, Lewis James Armitage, A. Soloshenko, Timothy Barklow, Jinhong Yu, Norbert Wermes, Marjorie Shapiro, Thomas Dennis Powell, Reinhard Schwienhorst, Veronika Magerl, Soshi Tsuno, S. L. Wu, T. Kawamoto, Sara Strandberg, A. De Maria, J. Boudreau, Philipp Stolte, Flavia De Almeida Dias, Iacopo Vivarelli, J. W. Smith, Matthew Edgar Leblanc, Tracey Berry, Marco Aurelio Diaz, Yumeng Cao, Alexander Undrus, Calum Michael Macdonald, Steven Patrick Alkire, Simon Henry Connell, Todd Seiss, Dj. Sijacki, Max Maerker, Mohamad Kassem Ayoub, Elizabeth Brost, Roman Lysak, J. A. Parsons, Arely Cortes-Gonzalez, Joseph Haley, Y. Huang, Ester Ricci, Lennart Adam, Stefan Koperny, Julie Kirk, Craig Sawyer, Susanne Kersten, Aidan Grummer, Sebastian Grinstein, Wolfgang Mader, F. Wang, Felix Mueller, Francesco Costanza, Y. Amaral Coutinho, Christoph Eckardt, Alexander Milov, C. J. E. Suster, Zuhua Jiang, Tim Martin, Bernhard Matthias Flierl, Qiaoshi Zeng, Soo Ryu, Theodora Papadopoulou, Benedikt Bergmann, Kun Liu, Nicholas Adam Styles, Federico Meloni, V. Izzo, Tatsuya Masubuchi, Oliver Keith Baker, Jiri Kvita, Francesco Crescioli, Tai-Hua Lin, Daria Zieminska, Reda Tafirout, Klaus Kurt Desch, Richard Nickerson, Julia Hrdinka, Francisco Alonso, A. J. Beddall, M. J. Kobel, P. Mättig, Ludovic Michel Scyboz, C. A. Chavez Barajas, Sebastian Liem, Victoria Jane Martin, Cecile Deterre, John Alison, Sara Valentinetti, Frank Winklmeier, L. R. Flores Castillo, Emily Charlotte Graham, David Freeborn, Shoji Asai, Claire Malone, A. Rodriguez Perez, P. C. F. Glaysher, Andrei Snesarev, Elena Murielle Freundlich, Steven Goldfarb, Z. G. Zhao, Ahmimed Ouraou, Johannes Elmsheuser, Klaudia Burka, Thomas Lohse, Laurent Schoeffel, Z. Xi, Guido Gagliardi, Alessandro Ambler, Heberth Torres, David Richard Shope, A. La Rosa, Joe Taenzer, Andrea Catinaccio, S. Li, Ilaria Luise, Fabrizio Scuri, Sergey Peleganchuk, Filipp Dubinin, Arnaud Lucotte, Y. A. Kurochkin, C. Young, Christine Kourkoumelis, P. Sinervo, Liza Mijović, E. 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Moa, Zeno Dixon Greenwood, Jason Tyler Colt Barkeloo, Sebastian Wahrmund, Jeroen Schouwenberg, Lidija Živković, Andrew Buckley, Marumi Kado, Fred Wickens, Yoichi Ninomiya, J. Del Peso, M. Pedersen, Chikara Fukunaga, Fares Djama, Stanley Lai, Cristina Galea, T. Saito, R.-J. Wang, Z. Liang, Bin Gui, Edoardo Maria Farina, Fernando Barreiro, O. E. Vickey Boeriu, Tomas Kosek, Adam Trzupek, Ivanka Hristova, Andrew Washbrook, Emilio Higón-Rodriguez, Kevin Black, Y. Delabat Diaz, Anne Marie Sickles, William Keaton Balunas, Tae Hyoun Park, E. P. Le Quilleuc, Alexey Zhemchugov, Dms Sultan, Huan Ren, J. Chudoba, Katja Hannele Mankinen, Igor Mandić, Thomas Daniel Weston, Yongke Zhao, Ning Zhou, Donatas Ramilas Zaripovas, C. H. Chen, Andrey Sapronov, Nicolas Berger, S. P. Amor Dos Santos, Fernando Monticelli, Wenhao Xu, Elena Yatsenko, Peter Krieger, Lluisa-Maria Mir, Mika Huhtinen, Julien Maurer, David Olivier Jamin, Anna Kathryn Duncan, Bernardo Sotto-Maior Peralva, H. Meyer Zu Theenhausen, Manuella Vincter, Anna Lipniacka, Sebastien Prince, Marc Weber, J. M. Iturbe Ponce, Denys Denysiuk, Michael A. Strauss, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ATLAS, Akilli, Ece, Amrouche, Cherifa Sabrina, Ancu, Lucian Stefan, Benoit, Mathieu, Calace, Noemi, Clark, Allan Geoffrey, Della Volpe, Domenico, Di Bello, Francesco Armando, Dubreuil, Arnaud, Ferrere, Didier, Gadatsch, Stefan, Golling, Tobias, Gonzalez Sevilla, Sergio, Iacobucci, Giuseppe, Iizawa, Tomoya, Jansky, Roland, Khoo, Teng Jian, Kiehn, Moritz, Lanfermann, Marie Christine, Lionti, Anthony Eric, March Ruiz, Luis, Mermod, Philippe, Paolozzi, Lorenzo, Poggi, Riccardo, Raine, Johnny, Salamani, Dalila, Schramm, Steven, Sfyrla, Anna, Sultan, D M S, Valente, Marco, Vicente Barreto Pinto, Mateus, Wu, Xin, Zaffaroni, Ettore, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Fakülteler, Fen - Edebiyat Fakültesi, Fizik Bölümü, Universidade do Minho, Aaboud, M, Bachas, K, Chiodini, G, Gorini, E, Gravili, F, Longo, L, Mirto, A, Primavera, M, Reale, M, Schioppa, E, Spagnolo, S, Ventura, A, ATLAS Collaboration, And, and Współautorami artykułu są członkowie ATLAS Collaboration w liczbie 2933
Subjects: electron, Physics and Astronomy (miscellaneous), 13000 GeV-cms, measured [channel cross section], Electron, W: leptonic decay, transverse momentum dependence, 01 natural sciences, Vector boson, High Energy Physics - Experiment, Subatomär fysik, High Energy Physics - Experiment (hep-ex), Atlas experiment, Gauge boson, Subatomic Physics, Electroweak interaction, scattering [p p], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], associated production [Z0], Physics, gauge boson: polarization, rapidity: difference, associated production [W], Atlas (topology), vector boson, mass: transverse, ATLAS experiment, higher-order: 2, Particle physics, perturbation theory: higher-order, ratio: measured [cross section], ATLAS, Helicity, decay modes [gauge boson], mass dependence, 2 [higher-order], difference [rapidity], CERN LHC Coll, kinematics, colliding beams [p p], W: associated production, channel cross section: measured, gauge boson: decay modes, Particle Physics - Experiment, perturbation theory [quantum chromodynamics], p p: scattering, Ciências Naturais::Ciências Físicas, Ciências Físicas [Ciências Naturais], polarization: longitudinal, FOS: Physical sciences, angular distribution [lepton], LHC, ATLAS, High Energy Physics, ddc:500.2, differential cross section: measured, measured [differential cross section], muon, 0103 physical sciences, ddc:530, High Energy Physics, quantum chromodynamics: perturbation theory, 010306 general physics, Engineering (miscellaneous), hadron hadron: interaction, interaction [hadron hadron], longitudinal [polarization], Muon, Science & Technology, lepton: angular distribution, 010308 nuclear & particles physics, hep-ex, High Energy Physics::Phenomenology, Física, leptonic decay [Z0], helicity, Z0: associated production, leptonic decay [W], higher-order [perturbation theory], transverse [mass], Experimental High Energy Physics, cross section: ratio: measured, Z0: leptonic decay, High Energy Physics::Experiment, polarization [gauge boson], p p: colliding beams, experimental results
Abstract: This paper presents measurements of W±Z production cross sections in pp collisions at a centre-of-mass energy of 13 TeV. The data were collected in 2015 and 2016 by the ATLAS experiment at the Large Hadron Collider, and correspond to an integrated luminosity of 36.1 fb−1. The W±Z candidate events are reconstructed using leptonic decay modes of the gauge bosons into electrons and muons. The measured inclusive cross section in the detector fiducial region for a single leptonic decay mode is σfid.W±Z→ℓ′νℓℓ=63.7± 1.0 (stat.)± 2.3 (syst.)± 1.4 (lumi.) fb, reproduced by the next-to-next-to-leading-order Standard Model prediction of 61.5+1.4−1.3 fb. Cross sections for W+Z and W−Z production and their ratio are presented as well as differential cross sections for several kinematic observables. An analysis of angular distributions of leptons from decays of W and Z bosons is performed for the first time in pair-produced events in hadronic collisions, and integrated helicity fractions in the detector fiducial region are measured for the W and Z bosons separately. Of particular interest, the longitudinal helicity fraction of pair-produced vector bosons is also measured., We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIEN-CIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS, CEA-DRF/IRFU, France; SRNSFG,Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, UK; DOE and NSF, USA. In addition, individual groups and members have received support from BCKDF, CANARIE, CRC and Compute Canada, Canada; COST, ERC, ERDF, Horizon 2020, and Marie Sklodowska-Curie Actions, European Union; Investissements d' Avenir Labex and Idex, ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSFNSF and GIF, Israel; CERCA Programme Generalitat de Catalunya, Spain; The Royal Society and Leverhulme Trust, UK. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA), the Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of computing resources are listed in Ref. [106]., info:eu-repo/semantics/publishedVersion
Published: 2019

13. A measurement of material in the ATLAS tracker using secondary hadronic interactions in 7 TeV pp collisions

Author: Massimo Lazzaroni, Raimund Ströhmer, Martina Pagáčová, Mark Slater, Andrew Nelson, W. K. Di Clemente, B. Åsman, Oldrich Kepka, Alessandra Baas, Armin Michael Nairz, V. Simak, Michele Pinamonti, Sabine Lammers, L. Lopes, Volker Büscher, A. T. Goshaw, Smita Darmora, Hernan Wahlberg, Tatsumi Koi, Robert Hickling, Maurice Garcia-Sciveres, Tomas Jakoubek, Krisztian Peters, Valentinos Christodoulou, T. R. V. Billoud, Zoya Karpova, Ki Lie, P. S. Wells, D. E. Ferreira de Lima, S. Prell, Rohin Narayan, M. A. Pleier, Florian Kiss, Sergey Karpov, Jie Zhang, James H Cochran, Marcela Mikestikova, Faten Hariri, Gideon Bella, Gabriella Gaudio, Adam Kaluza, Veronique Boisvert, Katsufumi Sato, Terry Richard Wyatt, D. Fassouliotis, Fumihiko Ukegawa, Andrea Formica, M. Faucci Giannelli, Mathis Kolb, J. Wang, Dmitriy Maximov, P. J. Clark, Edmund Dawe, Jacquelyn Brosamer, Venetios Polychronakos, Nurcan Ozturk, Janna Katharina Behr, Yury Smirnov, Christian Meineck, Ludovico Pontecorvo, Alexander Cheplakov, Haiping Peng, Yohei Yamaguchi, Paul Hodgson, S. R. Hou, H. J. Burckhart, Konstantin Toms, Yuri Kulchitsky, Peter Berta, Jacqueline Batley, Manuela Venturi, Babar Ali, Susanne Kuehn, Stephen Sekula, A. Loginov, Arthur Rene Chomont, S. Errede, Francesco Crescioli, Valerio Vercesi, Kazuki Todome, Mossadek Talby, Marumi Kado, Kerstin Tackmann, Olga Novgorodova, D. Su, Vincent Hedberg, Andrea Favareto, Xifeng Ruan, Loic Valery, S. Tanaka, Peter Onyisi, Paolo Dondero, Urmila Soldevila, Alexander Zaitsev, Ian Connelly, Juerg Beringer, B. G. Pope, Miroslav Hrabovsky, Kazunori Hanagaki, Iurii Naryshkin, Lucrezia Stella Bruni, William Quayle, Joe Taenzer, Kenji Hamano, Jos Vermeulen, K. J. C. Leney, Mark Scarcella, John Baines, Sergei Chekanov, Jemal Khubua, Silje Raddum, Simon Molander, W. J. Murray, Toshiaki Kaji, J. Bilbao De Mendizabal, Daniel Lellouch, Takahiro Fusayasu, M. T. Dova, B. M. Waugh, Claire Antel, Sylvestre Pires, Stephen Watts, Franz E. Bauer, Stefano Camarda, Gustaaf Brooijmans, Per Werner, Simon Head, Emily Thompson, Rinat Fakhrutdinov, Bengt Lund-Jensen, Katsuo Tokushuku, Sylvain Blunier, G. McGoldrick, Valerio Bortolotto, E. Torró Pastor, Susumu Oda, H. Czirr, MarioPaolo Giordani, Charles Leggett, Fabian Huegging, Frederick Dallaire, Nicolo Vladi Biesuz, Alexander Law, J. Wetter, Rute Pedro, H. M. Braun, Hiroyuki Iwasaki, John-Bjarne Hansen, G. T. Fletcher, V. Sanchez Martinez, Zach Marshall, E. Le Guirriec, Philipp Fleischmann, Alden Stradling, Lorenz Hauswald, Roger Jones, A. Firan, S. Binet, Krishnaiyengar Karthik, Aldo Saavedra, Atsuhiko Ochi, Hernan Reisin, J. Maurer, James Howarth, S. De Cecco, Alexi Gongadze, Giovanni Darbo, Jean-Francois Grivaz, Stefan Gadatsch, M. E. Pozo Astigarraga, Marianna Testa, Allan Lehan, Graeme Stewart, Simone Michele Mazza, Nikolaos Konstantinidis, Sebastian Mergelmeyer, N. G. Gutierrez Ortiz, Giorgi Arabidze, Elisabetta Pianori, Jordan S Webster, L. Bellagamba, Mazin Khader, Nedaa Asbah, E. Romero Adam, Aston Komar, Kyungeon Choi, Elisa Guido, Laurent Vacavant, Lukas Plazak, Stephen Haywood, Sotirios Vlachos, Walter Lampl, F. Parodi, Edward Moyse, Simon Berlendis, Evgeniy Khramov, M. Rescigno, Shuwei Ye, Takehiko Mori, Andrzej Olszewski, H. Namasivayam, P. de Jong, Christopher Samuel Pollard, Claudio Luci, Driss Benchekroun, Kunihiro Nagano, S. Campana, Annabelle Julia Chuinard, Silvia Fressard-Batraneanu, Stylianos Angelidakis, Janusz Chwastowski, Christian Grefe, Lidia Smirnova, G. Y. Jeng, Clement Helsens, Lorenzo Bianchini, Mattias Ellert, M. Losada, Peter Kluit, P. M. Tuts, Hiroshi Sakamoto, David Miller, Vladimir Vinogradov, Per Edvin Sidebo, Alberto Aloisio, Andrew Hard, Giancarlo Spigo, Kathleen Whalen, Athina Kourkoumeli-Charalampidi, Charles William Kalderon, Christophe Clement, Krzysztof Wozniak, Lene Bryngemark, Gianluca Alimonti, Rainer Stamen, Alexey Myagkov, Seyed Ruhollah Shojaii, Markus Cristinziani, Wolfgang Liebig, Sarah Kate Boutle, Xi Chen, Theodoros Alexopoulos, Mohamad Kassem Ayoub, Jun Gao, Arely Cortes-Gonzalez, Alexander Milov, L. Di Ciaccio, Francesca Ungaro, Christopher Potter, Gabriel Stoicea, Dilip Jana, Kristin Lohwasser, Dirk Sammel, Laurent Chevalier, Martin Tripiana, Dmitry Golubkov, Paul Mircea Gravila, Steven Goldfarb, Z. G. Zhao, Dorian Simon, A. Jinaru, Karlheinz Meier, Rui Wang, Paul Laycock, T. Ince, Yann Coadou, Gilbert Poulard, Faig Ahmadov, Emmanuel Sauvan, Sascha Caron, Vladimir Sulin, Rosy Nicolaidou, Nikolaos Rompotis, S. De Castro, J. E. Brau, R. Caputo, Roberto Spighi, Sylvain Tisserant, Wolfgang Walkowiak, Christopher Bee, Petr Vokac, Eduard Simioni, Frank Ellinghaus, G. Hughes, Christos Anastopoulos, Bianca Osculati, Dave Sankey, Konstantin Belotskiy, Liaoshan Shi, Leszek Adamczyk, Mario Campanelli, Lawrence Lee, Andrea Knue, Nicolas Morange, Steffen Henkelmann, Tobias Heck, P. Farthouat, Maurice Becker, Bruce Barnett, W. D. Breaden Madden, Joanna Knapik, V. Chernyatin, Jonathan Michael Hays, Osamu Jinnouchi, E. St. Panagiotopoulou, Peter Radloff, Stanislav Nemecek, Vincenzo Canale, Barbara Wosiek, Haijun Yang, Marc Geisen, Daniel Blackburn, Stefan Rave, M. Tyndel, Elizaveta Shabalina, Veljko Radeka, James Pinfold, T. Ženiš, Tomas Dado, T. Del Prete, John Rutherfoord, Florian Urs Bernlochner, Liron Barak, B. Sarrazin, C. Lapoire, Diane Cinca, B. K. B. Chow, T. J. Neep, Reiner Klingenberg, Helmut Wolters, Johanna Gramling, Stefano Rosati, Miguel Arratia, A. Olariu, Julia Isabell Djuvsland, K. G. 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Zeitnitz C., Zeman M., Zemla A., Zeng J.C., Zeng Q., Zengel K., Zenin O., Zenis T., Zerwas D., Zhang D., Zhang F., Zhang G., Zhang H., Zhang J., Zhang L., Zhang R., Zhang X., Zhang Z., Zhao X., Zhao Y., Zhao Z., Zhemchugov A., Zhong J., Zhou B., Zhou C., Zhou L., Zhou M., Zhou N., Zhu C.G., Zhu H., Zhu J., Zhu Y., Zhuang X., Zhukov K., Zibell A., Zieminska D., Zimine N.I., Zimmermann C., Zimmermann S., Zinonos Z., Zinser M., Ziolkowski M., Zivkovic L., Zobernig G., Zoccoli A., zur Nedden M., Zwalinski L., Współautorami artykułu są członkowie ATLAS Collaboration w liczbie 2857, Tong, Baojia, Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ATLAS Collaboration, Universidade do Minho, Aaboud, M., Aad, G., Abbott, B., Abdallah, J., Abdinov, O., Abeloos, B., Aben, R., Abouzeid, O. 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G., Zhu, H., Zhu, J., Zhu, Y., Zhuang, X., Zhukov, K., Zibell, A., Zieminska, D., Zimine, N. I., Zimmermann, C., Zimmermann, S., Zinonos, Z., Zinser, M., Ziolkowski, M., Zivkovic, L., Zobernig, G., Zoccoli, A., Zur Nedden, M., Zwalinski, L., Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Della Pietra, Massimo, Merola, Leonardo, Giordano, Raffaele, Conventi, Francesco, Rossi, Elvira, Carlino, Giampaolo, de Asmundis, Riccardo, Di Donato, Camilla, Doria, Ale, Ra, Iengo, Paolo, Izzo, Vincenzo, Perrella, Sabrina, Sekhniaidze, Givi, Cirotto, Francesco, Atlas, Collaboration, Aaboud, M, Chiodini, Gabriele, Gorini, Edoardo, Primavera, Margherita, Spagnolo, Stefania Antonia, Ventura, Andrea, and Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Physics::Instrumentation and Detectors, Ciencias Físicas, Hadron, secondary [vertex], 01 natural sciences, High Energy Physics - Experiment, purl.org/becyt/ford/1 [https], High Energy Physics - Experiment (hep-ex), [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], scattering [p p], of photons with matter, interaction of hadrons with matter, etc), tracking detector, Instrumentation, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Mathematical Physics, QC, Physics, Detector modelling and simulations I (interaction of radiation with matter, interaction of photons with matter, interaction of hadrons with matter, etc), Performance of high energy physics detectors, Large Hadron Collider, Atlas (topology), Detector, Settore FIS/01 - Fisica Sperimentale, exotic [particle], ATLAS, tracking, primary [vertex], CERN LHC Coll, Performance of High Energy Physics Detectors, Atlas, Tellurium compounds, Particle Physics - Experiment, performance, CIENCIAS NATURALES Y EXACTAS, Particle physics, 530 Physics, Ciências Naturais::Ciências Físicas, Ciências Físicas [Ciências Naturais], Detector modelling and simulations I (interaction of radiation with matter, interaction, FOS: Physical sciences, LHC, ATLAS, High Energy Physics, Material, Nuclear physics, 510 Mathematics, 0103 physical sciences, ddc:610, High Energy Physics, 010306 general physics, Ciencias Exactas, Science & Technology, 010308 nuclear & particles physics, tracks [charged particle], background, Física, purl.org/becyt/ford/1.3 [https], trigger, Astronomía, Experimental High Energy Physics, High Energy Physics::Experiment, hadron
Abstract: Knowledge of the material in the ATLAS inner tracking detector is crucial in understanding the reconstruction of charged-particle tracks, the performance of algorithms that identify jets containing b-hadrons and is also essential to reduce background in searches for exotic particles that can decay within the inner detector volume. Interactions of primary hadrons produced in pp collisions with the material in the inner detector are used to map the location and amount of this material. The hadronic interactions of primary particles may result in secondary vertices, which in this analysis are reconstructed by an inclusive vertex-finding algorithm. Data were collected using minimum-bias triggers by the ATLAS detector operating at the LHC during 2010 at centre-of-mass energy √s = 7 TeV, and correspond to an integrated luminosity of 19 nb-1. Kinematic properties of these secondary vertices are used to study the validity of the modelling of hadronic interactions in simulation. Secondary-vertex yields are compared between data and simulation over a volume of about 0.7 m3 around the interaction point, and agreement is found within overall uncertainties., La lista completa de autores que integran el documento puede consultarse en el archivo., Facultad de Ciencias Exactas, Instituto de Física La Plata
Published: 2016

14. Immune signatures and disorder-specific patterns in a cross-disorder gene expression analysis

Author: Margarita Rivera, Patrick Bolton, Susannah Whitwell, Philip Asherson, C. Ellie Wilson, Hamel Patel, Jose L. Paya-Cano, M. Andreina Mendez, Jamie Horder, Sang-hyuck Lee, Charlotte Tye, Declan G. Murphy, Charles Curtis, Simone de Jong, Karen L. Ashwood, Richard Dobson, Mark Pitts, Peter McGuffin, Stephen Newhouse, Gerome Breen, Stefanos Maltezos, Helen Costello, Sarah Curran, David Dempster, [de Jong,S, Newhouse,SJ, Patel,H, Lee,S, Dempster,D, Curtis,C, Paya-Cano, J] MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK. [Murphy,D] The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK. [. Wilson,E] The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King’s College London UK and Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, University of Seville, Spain. [Mendez,MA] PhD, The Sackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences,Institute of Psychiatry, Psychology & Neuroscience, King’s College London. [Asherson,P] MRC Social, Genetic & Developmental Psychiatry Centre,Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK. [Rivera,M] MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK and CIBERSAM-University of Granada and Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain. [Costello,H] Wolfson Centre for Age Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK. [Maltezos,S, Whitwell,S, Pitts,M] Adult ADHD Service, South London and Maudsley NHS Foundation Trust, London, UK. [Tye,C] Department of Child & Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK. [Ashwood,KL] Brighton and Sussex Medical School, University of Sussex, Brigton, UK. [Bolton,P] Department of Child & Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK. [Curran,S] Department of Child & Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London and Brighton and Sussex Medical School, University of Sussex, Brighton, UK. [McGuffin,P] MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK. [Dobson,R, Breen,G] MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London and NIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK., and This study presents independent research (part) funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. C.E.W. is funded through European Union’s Seventh Framework Programme via Marie Curie Action, co-financed by the Junta de Andalucı´a and the European Commission under Talentia Postdocgrant agreement number 267226
Subjects: 0301 basic medicine, Atención, Male, Autism Spectrum Disorder, Bioinformatics, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Psychiatry and Psychology::Mental Disorders::Mood Disorders::Depressive Disorder::Depressive Disorder, Major [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnosis, Dual (Psychiatry) [Medical Subject Headings], Young adult, Child, Middle Aged, 3. Good health, Humanos, Psychiatry and Mental health, Autism spectrum disorder, Papers, Diagnóstico dual (Psiquiatría), Major depressive disorder, Female, Psychology, Redes reguladoras de genes, Factores de riesgo, Adult, medicine.medical_specialty, Genómica, Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression::Transcription, Genetic::Transcriptome [Medical Subject Headings], Genomics, Phenomena and Processes::Genetic Phenomena::Genetic Structures::Base Sequence::Regulatory Sequences, Nucleic Acid::Gene Regulatory Networks [Medical Subject Headings], behavioral disciplines and activities, 03 medical and health sciences, Young Adult, Trastorno depresivo mayor, mental disorders, Psychiatry and Psychology::Psychological Phenomena and Processes::Psychophysiology::Arousal::Attention [Medical Subject Headings], medicine, Named Groups::Persons::Age Groups::Adult [Medical Subject Headings], Humans, Genetic Predisposition to Disease, Psychiatry, Depressive Disorder, Major, Gene Expression Profiling, Case-control study, Psychiatry and Psychology::Mental Disorders::Mental Disorders Diagnosed in Childhood::Child Development Disorders, Pervasive::Autism Spectrum Disorder [Medical Subject Headings], medicine.disease, Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology::Genomics [Medical Subject Headings], Gene expression profiling, Transcriptoma, 030104 developmental biology, Attention Deficit Disorder with Hyperactivity, Case-Control Studies, Etiology, Dual diagnosis, Trastorno del espectro autista, Trastorno por déficit de atención con hiperactividad, Psychiatry and Psychology::Mental Disorders::Mental Disorders Diagnosed in Childhood::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity [Medical Subject Headings]
Abstract: BackgroundRecent studies point to overlap between neuropsychiatric disorders in symptomatology and genetic aetiology.AimsTo systematically investigate genomics overlap between childhood and adult attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and major depressive disorder (MDD).MethodAnalysis of whole-genome blood gene expression and genetic risk scores of 318 individuals. Participants included individuals affected with adult ADHD (n = 93), childhood ADHD (n = 17), MDD (n = 63), ASD (n = 51), childhood dual diagnosis of ADHD–ASD (n = 16) and healthy controls (n = 78).ResultsWeighted gene co-expression analysis results reveal disorder-specific signatures for childhood ADHD and MDD, and also highlight two immune-related gene co-expression modules correlating inversely with MDD and adult ADHD disease status. We find no significant relationship between polygenic risk scores and gene expression signatures.ConclusionsOur results reveal disorder overlap and specificity at the genetic and gene expression level. They suggest new pathways contributing to distinct pathophysiology in psychiatric disorders and shed light on potential shared genomic risk factors.
Published: 2016

15. Measurement of the W±Z production cross section and limits on anomalous triple gauge couplings in proton–proton collisions at s=7 TeV with the ATLAS detector

Author: Carolina Gabaldon, Stefan Stonjek, T. Burgess, Frantisek Krejci, Mark Hodgkinson, A. Harvey, V. Bansal, Jiri Chudoba, R. Mackeprang, Eiliv Lund, A. Gonidec, S. W. Snow, D. Buira-Clark, B. Ruckert, E. Davies, J. de Graat, G. Mirabelli, Matt Dobbs, R. E. Long, B. Clement, Q. Ouyang, V. Martinez Outschoorn, Sascha Mehlhase, S. Horner, Cunfeng Feng, Yasushi Nagasaka, Boris Lemmer, R. J. Hawkings, M. A. Chelstowska, M. J. Losty, I. I. Tsukerman, P. Johansson, William Trischuk, A. Passeri, T. Delemontex, Antonio Policicchio, James Frost, Pier-Olivier Deviveiros, Jonas Strandberg, David Malon, Stefan Guindon, S. Fleischmann, Oxana Smirnova, T. Todorov, Konstantinos Bachas, L. Miralles Verge, E. Auge, Malte Backhaus, Pascal Pralavorio, Lamberto Luminari, Yona Oren, P. Renkel, B. Chapleau, Davide Costanzo, M. G. Wilson, J-P. Meyer, T. Lagouri, D. Tardif, Jean François Marchand, Maciej Trzebinski, G. Cortiana, M. L. Andrieux, Kristin Lohwasser, Philip Phillips, Samuel Silverstein, L. S. Gomez Fajardo, S. Stern, A. Gemmell, Tord Ekelof, Monica Verducci, E. B. Klinkby, K. Leonhardt, A. Succurro, Anna Kaczmarska, M. Fiascaris, Y. Munwes, K. Perez, J. A. Wilson, C. Hensel, M. Goebel, Tomas Slavicek, P. Lichard, R. Pengo, C. P. Marino, F. Marchese, Jean-Francois Laporte, Lidia Dell'Asta, R. Placakyte, C. Schroeder, Fabrice Hubaut, J. Cook, Dmitriy Maximov, M. Aurousseau, I. Turk Cakir, Kazunori Hanagaki, G. Nanava, Dongliang Zhang, M. E. Zeller, E. Sedykh, A. Khoroshilov, B. M. Waugh, M. Warsinsky, M. S. Levitski, V. N. Goryachev, V. V. Zmouchko, J. Biesiada, A. Tonoyan, Jongmin Lee, P. Valente, C. Lasseur, Margret Fincke-Keeler, Susan Cheatham, J. M. Joseph, T. Kuhl, Siarhei Harkusha, Jemal Khubua, Daniel Fournier, Susanne Kuehn, Laurent Vacavant, H. Czirr, Charles Leggett, M. Rammes, Fabian Huegging, A. M. Zaitsev, M. Mazzanti, A. A. Carter, M. Miñano Moya, A. Firan, S. Binet, Aldo Saavedra, Atsuhiko Ochi, S. Di Luise, James Howarth, Stephen Haywood, T. Nunnemann, Sotirios Vlachos, Walter Lampl, V. Moeller, F. Parodi, David Miller, Vladimir Vinogradov, Gabriel Stoicea, Thorsten Wengler, O. C. Jonsson, Matthias Klein, Alexey Talyshev, R. Giordano, Vladimir Cindro, Pierre-Hugues Beauchemin, J. D. Price, H. H. Williams, Francesco Michelangelo Giorgi, S. Swedish, R. Yoshida, G. Volpi, Aaron James Armbruster, S. Koenig, J. A. Gray, E. Reinherz-Aronis, M. Bendel, A. Rose, Giancarlo Spigo, R. Beccherle, Kathleen Whalen, S. Owen, Paul Laycock, Stefania Spagnolo, Daniel Muenstermann, R. P. Thun, I. Massa, Giuseppe Iacobucci, F. Salvatore, Torsten Harenberg, M. Henke, C. Schwanenberger, Iftach Sadeh, Christophe Royon, D. Tsionou, V. N. Gushchin, T. Sasaki, S. Youssef, G. Tong, A. Borisov, H. von der Schmitt, E. Valladolid Gallego, X. Espinal Curull, Diego Casadei, Doris Chromek-Burckhart, C. Heller, Steinar Stapnes, R. Ueno, Sahal Yacoob, Josh Moss, M. Robinson, R. Caputo, Roberto Spighi, M. Cooke, Corrinne Mills, Xifeng Ruan, M. Lichtnecker, E. Oliver Garcia, Isabelle Wingerter-Seez, Alessandro Tricoli, R. M. Buckingham, R. Bartoldus, P. Hurst, George Redlinger, S. Cheng, T. Kluge, K. Tokunaga, S. Schaetzel, Marcin Wladyslaw Wolter, Alexander Grillo, J. E. Sundermann, C. Zendler, M. Aliyev, K. Benslama, Robert McPherson, Andrea Catinaccio, W. Iwanski, A. G. Myagkov, K. Jelen, M. Tylmad, Arnaud Foussat, D. Imbault, N. Krieger, Iacopo Vivarelli, Stephen Watts, Franz E. Bauer, S. O. Holmgren, Katsuo Tokushuku, Eduardo Ros, Evgeny Soldatov, Enrique Kajomovitz, Sophie Trincaz-Duvoid, T. Frank, R. S. B. King, L. Batkova, I. Gough Eschrich, A. M. Cooper-Sarkar, J. A. Bogaerts, S. Rzaeva, Louise Skinnari, Moritz Backes, Gabriela Navarro, B. Budick, J. Nadal, Louis Helary, J. Colas, Marzio Nessi, E. Jankowski, T. Hayakawa, B. Pinto, Anna Mastroberardino, A. Filippas, O. Gutzwiller, Carlos Solans, M. Della Pietra, S. Gonzalez, B. Demirkoz, Yasuyuki Okumura, Nils Krumnack, D. Hayden, Emmanuel Sauvan, E. Von Toerne, Y. W. Liu, J. Ferland, Vivek Jain, Konrad Kleinknecht, Bjørn Hallvard Samset, L. A.M. Wiik, W. E. Cleland, Renat Sadykov, M. S. Alam, Thomas Koffas, Rudiger Voss, H. O. Ogren, Reda Tafirout, Klaus Kurt Desch, Richard Nickerson, Y. Davygora, J. Bouchami, Arnaud Lucotte, C. Geweniger, Benjamin Trocmé, J. Bronner, J. Sondericker, E. Brodet, R. J. Madaras, E. Segura, Marc Dobson, Andreas Battaglia, Georgios Stavropoulos, Y. A. Kurochkin, Liza Mijović, Robert Kehoe, Bruno Lenzi, M. Tsiakiris, C. M. Cuciuc, Michael Begel, G. Sellers, N. M. Bolnet, Minoru Hirose, A. Dotti, R. Wunstorf, Viktor Kramarenko, Rinat Fakhrutdinov, S. Johnert, Daniela Salvatore, A. Mayne, Michael Shupe, J. Beringer, L. Lipinsky, G. Alexandre, Giuseppe Francesco Tartarelli, M. El Kacimi, Akira Yamamoto, S. Thoma, Giovanni Siragusa, Sofia Chouridou, Jason Nielsen, Armen Vartapetian, T. P. Kokott, K. E. Johansson, Mark Stockton, Yoichi Ikegami, Christopher J. Kenney, L. La Rotonda, I. Hruska, H. Landsman, C. Topfel, B. De Lotto, S. Klous, Lj Simic, M. Legendre, Giacinto Piacquadio, R. Van Der Leeuw, D. C. Bailey, M. J. Tibbetts, Michele Bianco, R. Maenner, M. Zeman, A. Palma, J. Griffiths, Alexander Bogdanchikov, N. S. Knecht, Tapas Sarangi, Z. Czyczula, Teresa Barillari, V. M. Kotov, Seema Bahinipati, Y. Ilchenko, Stefan Schmitt, G. Romeo, Marine Kuna, S. W. O'Neale, Christopher Lester, Remi Zaidan, V. Consorti, D. T. Pignotti, Andrea Sansoni, J. Poll, M. Pohl, S. Baker, Martine Bosman, S. De Castro, M. Kenyon, F. Etienne, M. Giunta, N. Guttman, M. Nozaki, William James Dearnaley, B. Stugu, Nigel Hessey, Ricardo Gonçalo, B. Nordkvist, R. Mameghani, G. Lenzen, Cedric Serfon, Aleandro Nisati, J. G. Rocha de Lima, R. Davidson, E. Torrence, M. Leyton, A. Gupta, A. Do Valle Wemans, Olivier Arnaez, W. Fernando, Andrew White, Michal Svatos, E. Strauss, S. Sushkov, Giorgi Arabidze, Augusto Santiago Cerqueira, M. D. Joergensen, Alexander Kupco, Edoardo Gorini, Elliot Lipeles, Saleh Sultansoy, C. Daum, Antonio Salvucci, R. Tanaka, Ehud Duchovni, T. Spreitzer, K. Miyazaki, J. Lundquist, R. Perrino, Tohru Takeshita, Uta Klein, Darren Price, G. Vegni, Maria Smizanska, Kendall Reeves, H. Ten Kate, Fedor Prokoshin, Gabriella Pasztor, S. V. Kopikov, Beate Heinemann, T. P. A. Åkesson, M. Groh, Peter Wienemann, Jochen Schieck, Emmerich Kneringer, D. van der Ster, Donatella Cavalli, U. Mallik, C. Oropeza Barrera, M. Petteni, X. C. Lou, D. Rousseau, Andrea Negri, Michel Raymond, Victor Kukhtin, Petr Hamal, D. Ludwig, Pierre Savard, Nicole Ruckstuhl, P. Ryan, Erez Etzion, M. Werner, S. Campana, Simona Serena Bocchetta, J. E.M. Robinson, Peter Loch, W. Mohr, Nikolai Rusakovich, T. Mueller, C. J. Curtis, R. Alon, J. Farley, Kevin Varvell, O. Gabizon, T. T. Voss, G. D. Kekelidze, Z. Drásal, Iskander Ibragimov, G. Battistoni, J. B. De Vivie De Regie, Jan Kretzschmar, P. E. De Castro Faria Salgado, Steffen Schaepe, E. Hazen, Sergio Gonzalez-Sevilla, Uwe Bratzler, J. Boudreau, I. D. 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Rudolph, Arnaud Ferrari, Dominick Olivito, Karel Smolek, Werner Wiedenmann, J. M. Foster, E. Castaneda-Miranda, M. Ugland, Denis Salihagic, B. Jackson, Y. Mahalalel, Dan Pantea, V. Bartsch, A. Akiyama, Ilija Vukotic, M. Rijpstra, T. Dohmae, C. L. Lampen, Marjorie Shapiro, Soshi Tsuno, S. L. Wu, T. Kawamoto, Sara Strandberg, Tracey Berry, Marco Aurelio Diaz, Tim Martin, D. Hellmich, Tae Min Hong, M. Panuskova, J. D. Degenhardt, D. Lissauer, A. La Rosa, P. Sinervo, M. Marx, K. Randrianarivony, Toyonobu Okuyama, K. Tollefson, J. Lundberg, M. Shimojima, Bartlomiej Zabinski, Krzysztof Korcyl, S. T. French, M. Bunse, Liyuan Han, J. P. Martin, Laurent Serin, M. Kollefrath, Sven Becker, A. Muir, A. Lewis, T. W. Jones, M. Wright, Anna Goussiou, Petr Gallus, Y. Komori, A. V. Kotwal, R. J. Teuscher, Stan Bentvelsen, J. C. Vermeulen, J. Weber, Joaquin Poveda, Timothee Theveneaux-Pelzer, M. Consonni, Antonio Zoccoli, E. Acerbi, F. Hahn, M. Rammensee, Jahred Adelman, D. R. Botterill, S. Pagan Griso, Alexandre Vaniachine, F. Cevenini, J. Thadome, T. Akdogan, L. Nodulman, M. Ahsan, Christian Ohm, Andreas Warburton, M. Ramstedt, J. Therhaag, H. Hakobyan, G. Calderini, Carmen García, Dirk L. Hoffmann, M. Villaplana Perez, Gregor Kramberger, T. Schwindt, Iro Koletsou, Peter Steinberg, Anatoli Romaniouk, Horst Severini, Malik Aliev, C. Kummer, Susumu Terada, Vladimir Smakhtin, Andreas Kugel, Thomas Trefzger, Elliot Hughes, Daniel Scheirich, C. Cuenca Almenar, J. G. Cogan, D. Capriotti, G. Zevi della Porta, Luis March, C. Joram, H. Przysiezniak, F. Khalil-zada, James Shank, Christian Weiser, Paolo Laurelli, K. Suita, Barbara Liberti, M. Pecsy, Gabriel Alexandru Popeneciu, Marcel Vos, Y. Bai, Aidan Randle-Conde, Hubert Kroha, Flera Rizatdinova, T. Sugimoto, Hong Ma, Cheng Guang Zhu, S. L. Cheung, John Derek Chapman, W. Kozanecki, S. Patricelli, T. O. Niinikoski, Henso Abreu, R. Zitoun, Marcella Capua, P. J. Clark, Bellisario Esposito, S. Vallecorsa, Y. Suzuki, J. L. Lane, Stephen Burke, K. Fowler, Alexandra Tudorache, T. Stahl, Peter Onyisi, E. Graziani, Lidia Smirnova, Laurent Chevalier, Tetiana Hryn'ova, Michael Flowerdew, Reyhaneh Rezvani, Urmila Soldevila, Christoph Posch, Kerstin Jon-And, K. Mahboubi, J. Silva, Kiyotomo Kawagoe, M. I. Pedraza Morales, W. J. Mills, J. Dubbert, Jean-Francois Grivaz, Martin Hoeferkamp, Milos Lokajicek, Mara Senghi Soares, Mariusz Przybycien, Michael Andrew Parker, M. Corradi, L. Zhao, A. J. Martin, C. Vellidis, Calin Alexa, C. Wright, Claudio Luci, R. Herrberg, Stephanie Majewski, P. Yu Nechaeva, Rachik Soualah, G. Luijckx, A. Richards, Ulrich Parzefall, M. Ziolkowski, Scott Snyder, Driss Benchekroun, Kunihiro Nagano, S. Eckweiler, Carlos Lacasta, Masaya Ishino, E. Turlay, Remi Lafaye, T. Del Prete, John Rutherfoord, C. Dionisi, H. Brown, Johannes Erdmann, J. Lys, Xiaohu Sun, C. Lapoire, Diane Cinca, A. Di Mattia, Philippe Mermod, Michel Vetterli, Heidi Sandaker, A. Ishikawa, Sten Hellman, Jan Andre Stillings, Matthias Hamer, R. Cherkaoui El Moursli, B. Gibbard, Reiner Klingenberg, Helmut Wolters, Vladimir Nikolaenko, Z. Weng, A. M. Kiver, Dimitrios Sampsonidis, A. Penson, Nikola Makovec, Ian Michael Nugent, Imma Riu, J. Mechnich, C. H. Wang, V. Kaushik, T. Meguro, Andreas Redelbach, Farid Ould-Saada, R. Spiwoks, Jean-Christophe Gayde, L. P. Says, E. Berglund, L. De Mora, B. Gosdzik, Alex Martyniuk, Wolfgang Wagner, A. M. Moisseev, P. F. Klok, Bostjan Macek, A. Chilingarov, Marie-Hélène Genest, L. Pribyl, A. Barbaro Galtieri, R. St. Denis, G. Ciapetti, Vasiliki Kouskoura, Bing Zhou, Didier Ferrere, Odette Benary, Mihai Caprini, J. Gunther, Marco Costa, Trisha Farooque, Tobias Kruker, M. Holder, Alexander Paramonov, M. Franklin, F.C. Pastore, Philippe Calfayan, P. van Gemmeren, F. E. Taylor, Z. L. Ren, J. Labbe, A. T. Waugh, Claudia Gemme, Michel Janus, A. Eppig, K. Nikolics, G. Blanchot, V. Rumiantsev, Kaushik De, A. Marin, Georgios Iakovidis, J. D. Palmer, Albert Olariu, Mikhail Demichev, Milind Purohit, Libor Nozka, M. Fokitis, A. Pinder, A. Onofre, Jan Stark, D. A. Soh, N. Bousson, M. L. Ferrer, Henry Lubatti, Raquel Pezoa, Yasuhiro Homma, Evelin Meoni, and V. Nguyen Thi Hong
Subjects: Physics, Nuclear and High Energy Physics, Particle physics, Muon, Proton, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, ATLAS experiment, Electron, Gauge (firearms), 01 natural sciences, 7. Clean energy, Standard Model, Nuclear physics, medicine.anatomical_structure, Atlas (anatomy), 0103 physical sciences, medicine, Physics::Accelerator Physics, High Energy Physics::Experiment, 010306 general physics, Boson
Abstract: This Letter presents a measurement of W(+/-)Z production in 1.02 fb(-1) of pp collision data at root s = 7 TeV collected by the ATLAS experiment in 2011. Doubly leptonic decay events are selected w ...
Published: 2012

16. ADHD symptom presentation and trajectory in adults with borderline and mild intellectual disability

Author: Stefanos Maltezos, Esther Rose, Elena Paliokosta, Kiriakos Xenitidis, and Jessica Bramham
Subjects: medicine.medical_specialty, Intelligence quotient, business.industry, Rehabilitation, medicine.disease, Developmental disorder, Psychiatry and Mental health, Neurology, Arts and Humanities (miscellaneous), Publishing, Intellectual disability, medicine, Attention deficit hyperactivity disorder, Neurology (clinical), Young adult, Presentation (obstetrics), business, Psychiatry, Psychology
Abstract: The definitive version is available at : http://www3.interscience.wiley.com/ Copyright Blackwell Publishing [Full text of this article is not available in the UHRA]
Published: 2010

17. Assessment of mental health problems in people with autism

Author: Stefanos Maltezos, Kiriakos Xenitidis, Vangelis Pappas, and Elena Paliokosta
Subjects: medicine.medical_specialty, Mental health law, Mind-blindness, Building and Construction, medicine.disease, Mental health, Prevalence of mental disorders, Autism spectrum disorder, mental disorders, Intellectual disability, medicine, Attention deficit hyperactivity disorder, Autism, Psychology, Psychiatry, Clinical psychology
Abstract: The general public and professionals from a range of backgrounds have increasingly become interested in autism spectrum disorders. This interest is particularly relevant to learning disability practitioners. Both autism and learning disabilities are independently associated with increased risk of mental health problems. Thus, when a person has learning disabilities and an autism spectrum disorder, a comprehensive assessment for mental health problems is of paramount importance. This paper provides an overview of the assessment of mental health problems in adults and children with neurodevelopmental disorders. The general assessment principles are outlined followed by assessment issues related to specific conditions such as psychoses, mood disorders and attention deficit hyperactivity disorder. Finally conclusions on the clinical implications are drawn.
Published: 2007

18. Attention deficit hyperactivity disorder in adults with learning disabilities

Author: Stefanos Maltezos and Kiriakos Xenitidis
Subjects: education.field_of_study, medicine.medical_specialty, Population, medicine.disease, Affect (psychology), behavioral disciplines and activities, law.invention, Psychiatry and Mental health, Neurodevelopmental disorder, Randomized controlled trial, law, mental disorders, Intellectual disability, Learning disability, medicine, Attention deficit hyperactivity disorder, Pshychiatric Mental Health, medicine.symptom, Everyday life, education, Psychology, Psychiatry
Abstract: Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder and symptoms often persist in adult life resulting in significant impairment. ADHD is increasingly recognized as occurring in children and adults with learning disability. ADHD symptoms were found to affect everyday life performance and to increase the impairment imposed by the learning disability, suggesting a double vulnerability and indicating the need for treatment. Although treatment of ADHD in this population has not been tested widely and randomized controlled trials are sparse, there is some evidence that pharmacological treatment can be effective. Thorough assessment of ADHD and comorbid conditions, and appropriate management is warranted.
Published: 2009

19. Attention-Deficit Hyperactivity Disorder (ADHD)

Author: Philip Asherson, Kiriakos Xenitidis, and Stefanos Maltezos
Subjects: medicine.medical_specialty, Challenging behaviour, Context (language use), medicine.disease, Mental illness, behavioral disciplines and activities, mental disorders, Intellectual disability, medicine, Autism, Attention deficit hyperactivity disorder, Identification (psychology), Psychology, Psychiatry, Association (psychology)
Abstract: People with intellectual disability (ID) are more susceptible to mental disorders including mental illness and developmental disorders, such as autism and attention-deficit hyperactivity disorder (ADHD). Identification of such comorbidities is important, as it has implications for diagnosis as well as treatment and prognosis. In this chapter the association between ADHD and ID is explored. The evidence for the validity of the diagnosis of ADHD in ID is reviewed. Subsequently, the assessment and diagnosis of ADHD in the context of ID is discussed. Finally, issues of treatment and management are highlighted.
Published: 2013

20. Comparison of ICD-10R, DSM-IV-TR and DSM-5 in an adult autism spectrum disorder diagnostic clinic

Author: Stefanos Maltezos, Chris Ohlsen, Clodagh M. Murphy, Debbie Spain, Maria Andreina Mendez, Nicola Gillan, Janneke Zinkstok, Gedeon Roberts, C. Ellie Wilson, Katie Johnston, Christina Dardani, Dene Robertson, Declan G. Murphy, P. Quinton Deeley, Francesca Happé, and Michael C. Craig
Subjects: Adult, Male, medicine.medical_specialty, genetic structures, Adolescent, behavioral disciplines and activities, Sensitivity and Specificity, DSM-5, Young Adult, mental disorders, Developmental and Educational Psychology, medicine, Humans, Young adult, Asperger Syndrome, Autistic Disorder, Psychiatry, Aged, Social communication, Middle Aged, medicine.disease, Dsm iv tr, Diagnostic and Statistical Manual of Mental Disorders, Autism spectrum disorder, Asperger syndrome, Child Development Disorders, Pervasive, Clinical diagnosis, Autism, Female, Psychology
Abstract: An Autism Spectrum Disorder (ASD) diagnosis is often used to access services. We investigated whether ASD diagnostic outcome varied when DSM-5 was used compared to ICD-10R and DSM-IV-TR in a clinical sample of 150 intellectually able adults. Of those diagnosed with an ASD using ICD-10R, 56 % met DSM-5 ASD criteria. A further 19 % met DSM-5 (draft) criteria for Social Communication Disorder. Of those diagnosed with Autistic Disorder/Asperger Syndrome on DSM-IV-TR, 78 % met DSM-5 ASD criteria. Sensitivity of DSM-5 was significantly increased by reducing the number of criteria required for a DSM-5 diagnosis, or by rating ‘uncertain’ criteria as ‘present’, without sacrificing specificity. Reduced rates of ASD diagnosis may mean some ASD individuals will be unable to access clinical services.
Published: 2013

21. Atomoxetine for Attention Deficit Hyperactivity Disorder (ADHD) in people with intellectual disabilities

Author: Alex Thomson, Stefanos Maltezos, Elena Paliokosta, and Kiriakos Xenitidis
Published: 2011

22. ADHD in adults. Your guide to today's mental health issues

Author: Kiriakos, Xenitidis, Stefanos, Maltezos, and Mark, Pitts
Subjects: Adult, Mental Health Services, England, Attention Deficit Disorder with Hyperactivity, Practice Guidelines as Topic, Humans, Continuity of Patient Care
Published: 2011

23. Assessing the impact of risk-taking behavior on road crash involvement among University students residing in two Mediterranean countries

Author: Evi Germeni, Constantine N. Antonopoulos, Flora Bacopoulou, Stella S. Daskalopoulou, Eva Negri, Vassiliki Kalampoki, Eleni Petridou, Ilias Skalkidis, Stefanos Maltezos, Antonopoulos CN, Germeni E, Bacopoulou F, Kalampoki V, Maltezos S, Skalkidis I, Daskalopoulou S, Negri E, and Petridou E
Subjects: Engineering, medicine.medical_specialty, business.industry, Public health, education, Public Health, Environmental and Occupational Health, Poison control, Computer security, computer.software_genre, Suicide prevention, Occupational safety and health, Drunk drivers, Health promotion, Environmental health, Injury prevention, medicine, Safety, Risk, Reliability and Quality, business, Risk assessment, Safety Research, computer, human activities
Abstract: Surveillance systems are indispensable for injury prevention; yet, detailed electronic records are rarely available. The "Student's Health Card" is a self-reporting electronic tool addressing health issues of University students, while aiming to actively involve them in preventive practices and health promotion. Utilizing data from the injury prevention related section, this study sought to investigate the impact of risk-taking behavior on road crash involvement among University students residing in two Mediterranean countries. A total of 978 University students, 451 Greek and 527 Italian, provided information on prior road crash involvement, as well as on eight behavioral variables, comprising a risky behavior score. Multiple logistic regression analysis was performed. The already known tendency for clustering of risky behaviors was evident. One degree increment in the risky behavior score was found to increase the risk of road crash involvement by 35%. Driving after drinking (OR = 2.55, CI = 1.53-4.26), riding with a drunk driver (OR = 2.19, CI = 1.08-4.45) and tobacco smoking (OR = 1.95, CI = 1.18-3.22) significantly multiplied the risk. Despite their better compliance with safety measures, Italian students, compared with Greek, reported worse alcohol-related driving habits and engaged more frequently in mobile phone use while driving. Clustering of risky behaviors was found to be an important predictor of road crash involvement. Screening and awareness of risk-taking propensity of University students could guide early intervention. The "Student's Health Card" could provide, at minimal cost, reliable risk-taking and road crash involvement information, which is needed for both personal risk assessment and surveillance purposes. (C) 2011 Elsevier Ltd. All rights reserved.
Published: 2011

24. Describing the brain in autism in five dimensions--magnetic resonance imaging-assisted diagnosis of autism spectrum disorder using a multiparameter classification approach

Author: Stefanos Maltezos, Michael Brammer, Andre F. Marquand, Clodagh M. Murphy, Eileen Daly, Dene Robertson, Patrick Johnston, Janaina Mourao-Miranda, Steven Williams, Declan G. Murphy, and Christine Ecker
Subjects: Adult, Male, Statistics as Topic, Severity of Illness Index, Brain anatomy, Young Adult, mental disorders, medicine, Image Processing, Computer-Assisted, Attention deficit hyperactivity disorder, Humans, Cortical surface, Autistic Disorder, Child, Aged, Intelligence Tests, Brain Mapping, medicine.diagnostic_test, General Neuroscience, Brain, Magnetic resonance imaging, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Support vector machine, medicine.anatomical_structure, ROC Curve, Autism spectrum disorder, Attention Deficit Disorder with Hyperactivity, Child Development Disorders, Pervasive, Case-Control Studies, Autism, Psychology, Neuroscience, Neuroanatomy
Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental condition with multiple causes, comorbid conditions, and a wide range in the type and severity of symptoms expressed by different individuals. This makes the neuroanatomy of autism inherently difficult to describe. Here, we demonstrate how a multiparameter classification approach can be used to characterize the complex and subtle structural pattern of gray matter anatomy implicated in adults with ASD, and to reveal spatially distributed patterns of discriminating regions for a variety of parameters describing brain anatomy. A set of five morphological parameters including volumetric and geometric features at each spatial location on the cortical surface was used to discriminate between people with ASD and controls using a support vector machine (SVM) analytic approach, and to find a spatially distributed pattern of regions with maximal classification weights. On the basis of these patterns, SVM was able to identify individuals with ASD at a sensitivity and specificity of up to 90% and 80%, respectively. However, the ability of individual cortical features to discriminate between groups was highly variable, and the discriminating patterns of regions varied across parameters. The classification was specific to ASD rather than neurodevelopmental conditions in general (e.g., attention deficit hyperactivity disorder). Our results confirm the hypothesis that the neuroanatomy of autism is truly multidimensional, and affects multiple and most likely independent cortical features. The spatial patterns detected using SVM may help further exploration of the specific genetic and neuropathological underpinnings of ASD, and provide new insights into the most likely multifactorial etiology of the condition.
Published: 2010

25. Risperidone for attention-deficit hyperactivity disorder in people with intellectual disabilities

Author: Stefanos Maltezos, Elena Paliokosta, Alex B. Thomson, and Kiriakos Xenitidis
Subjects: Adult, medicine.medical_specialty, Population, Persons with Mental Disabilities, MEDLINE, PsycINFO, Irritability, Intellectual disability, medicine, Attention deficit hyperactivity disorder, Humans, Pharmacology (medical), Psychiatry, education, Child, Randomized Controlled Trials as Topic, education.field_of_study, Psychotropic Drugs, Risperidone, business.industry, medicine.disease, Fragile X syndrome, Attention Deficit Disorder with Hyperactivity, medicine.symptom, business, medicine.drug
Abstract: BACKGROUND Attention-deficit hyperactivity disorder (ADHD) is increasingly recognised as occurring in people with intellectual disability (ID), although treatment of ADHD in this population has not been tested widely. Amfetamine has been used to treat ADHD in people with and without ID, although the evidence for its efficacy in people with ID is unclear. OBJECTIVES To examine the effectiveness of amfetamine for the treatment of attention deficit hyperactivity disorder in people with intellectual disabilities. SEARCH STRATEGY MEDLINE, PsycINFO, EMBASE, AMED, ISI Web of Science and WorldCat Dissertations were searched using an extensive list of synonyms for ADHD and ID. CENTRAL, Current Controlled Trials meta-register (mRCT), CenterWatch, NHS National Research Register, clinicaltrials.gov were searched in August 2007. Pharmaceutical companies and experts in the field were contacted. Reference lists of review articles were examined and citation searches were performed in ISI Web of Knowledge. SELECTION CRITERIA All randomised controlled studies, both published and unpublished, in any language, in which children or adults with ADHD and ID were treated with amfetamine. DATA COLLECTION AND ANALYSIS Data were extracted independently by two reviewers using a standardised extraction sheet. Risk of bias was assessed by two authors using a standardised framework. Meta-analyses were planned but were not performed due to a lack of suitable studies. MAIN RESULTS Only one study was suitable for inclusion. This was a cross-over study in 15 children with ADHD, ID and Fragile X syndrome. Duration of treatment was only one week. No significant difference was reported between amfetamine and placebo for any of the ADHD measures, but significantly more side effects were reported while taking amfetamine, mainly mood lability and irritability. AUTHORS' CONCLUSIONS There is very little evidence for the effectiveness of amfetamine for ADHD in people with ID . Prescribing in this population is based on extrapolation of research in people without ID. More research into effectiveness and tolerability is urgently needed.
Published: 2009

26. Amfetamine for attention deficit hyperactivity disorder in people with intellectual disabilities

Author: Alex Thomson, Stefanos Maltezos, Elena Paliokosta, and Kiriakos Xenitidis
Subjects: Amphetamine, Attention Deficit Disorder with Hyperactivity, Child, Preschool, Fragile X Syndrome, Persons with Mental Disabilities, Methylphenidate, Humans, Pharmacology (medical), Central Nervous System Stimulants, Child
Abstract: BACKGROUND: Attention‐deficit hyperactivity disorder (ADHD) is increasingly recognised as occurring in people with intellectual disability (ID), although treatment of ADHD in this population has not been tested widely. Amfetamine has been used to treat ADHD in people with and without ID, although the evidence for its efficacy in people with ID is unclear. OBJECTIVES: To examine the effectiveness of amfetamine for the treatment of attention deficit hyperactivity disorder in people with intellectual disabilities. SEARCH METHODS: MEDLINE, PsycINFO, EMBASE, AMED, ISI Web of Science and WorldCat Dissertations were searched using an extensive list of synonyms for ADHD and ID. CENTRAL, Current Controlled Trials meta‐register (mRCT), CenterWatch, NHS National Research Register, clinicaltrials.gov were searched in August 2007. Pharmaceutical companies and experts in the field were contacted. Reference lists of review articles were examined and citation searches were performed in ISI Web of Knowledge. SELECTION CRITERIA: All randomised controlled studies, both published and unpublished, in any language, in which children or adults with ADHD and ID were treated with amfetamine. DATA COLLECTION AND ANALYSIS: Data were extracted independently by two reviewers using a standardised extraction sheet. Risk of bias was assessed by two authors using a standardised framework. Meta‐analyses were planned but were not performed due to a lack of suitable studies. MAIN RESULTS: Only one study was suitable for inclusion. This was a cross‐over study in 15 children with ADHD, ID and Fragile X syndrome. Duration of treatment was only one week. No significant difference was reported between amfetamine and placebo for any of the ADHD measures, but significantly more side effects were reported while taking amfetamine, mainly mood lability and irritability. AUTHORS' CONCLUSIONS: There is very little evidence for the effectiveness of amfetamine for ADHD in people with ID . Prescribing in this population is based on extrapolation of research in people without ID. More research into effectiveness and tolerability is urgently needed.
Published: 2009

27. The clinical presentation of ADHD in adults with Learning Disability: experience from a National Specialist Adult ADHD clinic

Author: Elena Paliokosta, Jessica Bramham, Esther Rose, Stefanos Maltezos, and Kiriakos Xenitidis
Subjects: Empirical data, medicine.medical_specialty, lcsh:RC435-571, media_common.quotation_subject, fungi, food and beverages, behavioral disciplines and activities, Presentation, Psychiatry and Mental health, Forensic psychiatry, lcsh:Psychiatry, mental disorders, Learning disability, medicine, Psychopharmacology, Adhd symptoms, medicine.symptom, Psychology, Psychiatry, Geriatric psychiatry, Clinical psychology, media_common
Abstract: There is growing evidence that ADHD is more common inchildren and adults with Learning Disabilities (LD) andthat it can be successfully treated even if diagnosis can bedifficult because of ‘diagnostic overshadowing’. This studyprovides empirical data about the ADHD symptoms in LDand non-LD populations.
Published: 2008

28. Atomoxetine for attention deficit hyperactivity disorder in people with intellectual disabilities

Author: Alex Thomson, Stefanos Maltezos, Elena Paliokosta, and Kiriakos Xenitidis
Published: 2008

29. Rates of undiagnosed attention deficit hyperactivity disorder in London drug and alcohol detoxification units

Author: Amy Hammon, Zoe Huntley, Charlotte A. Williams, Karen Glaser, Raoul Howe-Forbes, Alun Morinan, Philip Asherson, Patrik Bolton, Stefanos Maltezos, E. Jane Marshall, David Ball, Declan G. Murphy, Susan Young, Kiriakos Xenitidis, Francis Keaney, and Jonna Kuntsi
Subjects: Drug, Adult, Male, medicine.medical_specialty, lcsh:RC435-571, Substance-Related Disorders, media_common.quotation_subject, medicine.medical_treatment, Suicide, Attempted, Comorbidity, behavioral disciplines and activities, lcsh:Psychiatry, mental disorders, Interview, Psychological, London, medicine, Prevalence, Attention deficit hyperactivity disorder, Humans, Autistic Disorder, Psychiatry, Depression (differential diagnoses), media_common, Psychiatric Status Rating Scales, Alcohol detoxification, Middle Aged, medicine.disease, Mental health, Substance abuse, Psychiatry and Mental health, Attention Deficit Disorder with Hyperactivity, Inactivation, Metabolic, Female, Substance use, Psychology, Clinical psychology, Research Article
Abstract: Background ADHD is a common childhood onset mental health disorder that persists into adulthood in two-thirds of cases. One of the most prevalent and impairing comorbidities of ADHD in adults are substance use disorders. We estimate rates of ADHD in patients with substance abuse disorders and delineate impairment in the co-morbid group. Method Screening for ADHD followed by a research diagnostic interview in people attending in-patient drug and alcohol detoxification units. Results We estimated prevalence of undiagnosed ADHD within substance use disorder in-patients in South London around 12%. Those individuals with substance use disorders and ADHD had significantly higher self-rated impairments across several domains of daily life; and higher rates of substance abuse and alcohol consumption, suicide attempts, and depression recorded in their case records. Conclusions This study demonstrates the high rates of untreated ADHD within substance use disorder populations and the association of ADHD in such patients with greater levels of impairment. These are likely to be a source of additional impairment to patients and represent an increased burden on clinical services.
Published: 2012

30. A Spatiotemporal Profile of In Vivo Cerebral Blood Flow Changes Following Intranasal Oxytocin in Humans

Author: Matthew A. Howard, Aikaterini Fotopoulou, Orla Doyle, Yannis Paloyelis, Stefanos Maltezos, Steven Williams, and Fernando Zelaya
Subjects: 0301 basic medicine, Male, Arterial spin labeling, Rest, cerebral blood flow, Oxytocin, Pattern Recognition, Automated, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Social cognition, oxytocin, pharmacodynamics, medicine, Humans, Single-Blind Method, Resting state, resting state, Biological Psychiatry, Administration, Intranasal, Brain Mapping, Resting state fMRI, intranasal, Brain, Cognition, Human brain, Cerebral blood flow, medicine.disease, Oxytocin receptor, Magnetic Resonance Imaging, 030104 developmental biology, medicine.anatomical_structure, Intranasal, Pharmacodynamics, Cerebrovascular Circulation, Multivariate Analysis, Autism, arterial spin labelling, Psychology, Neuroscience, 030217 neurology & neurosurgery, medicine.drug, Central Nervous System Agents
Abstract: BACKGROUND: Animal and human studies highlight the role of oxytocin in social cognition and behavior and the potential of intranasal oxytocin (IN-OT) to treat social impairment in individuals with neuropsychiatric disorders such as autism. However, extensive efforts to evaluate the central actions and therapeutic efficacy of IN-OT may be marred by the absence of data regarding its temporal dynamics and sites of action in the living human brain. METHODS: In a placebo-controlled study, we used arterial spin labeling to measure IN-OT-induced changes in resting regional cerebral blood flow (rCBF) in 32 healthy men. Volunteers were blinded regarding the nature of the compound they received. The rCBF data were acquired 15 min before and up to 78 min after onset of treatment onset (40 IU of IN-OT or placebo). The data were analyzed using mass univariate and multivariate pattern recognition techniques. RESULTS: We obtained robust evidence delineating an oxytocinergic network comprising regions expected to express oxytocin receptors, based on histologic evidence, and including core regions of the brain circuitry underpinning social cognition and emotion processing. Pattern recognition on rCBF maps indicated that IN-OTinduced changes were sustained over the entire posttreatment observation interval (25–78 min) and consistent with a pharmacodynamic profile showing a peak response at 39–51 min. CONCLUSIONS: Our study provides the first visualization and quantification of IN-OT-induced changes in rCBF in the living human brain unaffected by cognitive, affective, or social manipulations. Our findings can inform theoretical and mechanistic models regarding IN-OT effects on typical and atypical social behavior and guide future experiments (e.g., regarding the timing of experimental manipulations).
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31. Immune signatures and disorder-specific patterns in a cross-disorder gene expression analysis.

Author: de Jong S, Newhouse SJ, Patel H, Lee S, Dempster D, Curtis C, Paya-Cano J, Murphy D, Wilson CE, Horder J, Mendez MA, Asherson P, Rivera M, Costello H, Maltezos S, Whitwell S, Pitts M, Tye C, Ashwood KL, Bolton P, Curran S, McGuffin P, Dobson R, and Breen G
Subjects: Adult, Attention Deficit Disorder with Hyperactivity complications, Autism Spectrum Disorder complications, Case-Control Studies, Child, Female, Genetic Predisposition to Disease genetics, Humans, Male, Middle Aged, Young Adult, Attention Deficit Disorder with Hyperactivity genetics, Autism Spectrum Disorder genetics, Depressive Disorder, Major genetics, Gene Expression Profiling
Abstract: Background: Recent studies point to overlap between neuropsychiatric disorders in symptomatology and genetic aetiology., Aims: To systematically investigate genomics overlap between childhood and adult attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and major depressive disorder (MDD)., Method: Analysis of whole-genome blood gene expression and genetic risk scores of 318 individuals. Participants included individuals affected with adult ADHD (n = 93), childhood ADHD (n = 17), MDD (n = 63), ASD (n = 51), childhood dual diagnosis of ADHD-ASD (n = 16) and healthy controls (n = 78)., Results: Weighted gene co-expression analysis results reveal disorder-specific signatures for childhood ADHD and MDD, and also highlight two immune-related gene co-expression modules correlating inversely with MDD and adult ADHD disease status. We find no significant relationship between polygenic risk scores and gene expression signatures., Conclusions: Our results reveal disorder overlap and specificity at the genetic and gene expression level. They suggest new pathways contributing to distinct pathophysiology in psychiatric disorders and shed light on potential shared genomic risk factors., Competing Interests: Declaration of interest G.B. acts a consultant in preclinical genomics for Eli Lilly., (© The Royal College of Psychiatrists 2016.)
Published: 2016
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31 results on '"Stefanos Maltezos"'

1. Poor response to methylphenidate is associated with a smaller dorsal attentive network in adult Attention-Deficit/Hyperactivity Disorder (ADHD)

2. Reduced inferior fronto-insular-thalamic activation during failed inhibition in young adults with combined ASD and ADHD compared to typically developing and pure disorder groups

3. Comparison of an online adaptation of the Autism Diagnostic Observation Schedule-2 with its in-person version in an adult autism diagnostic service

4. The key role of daytime sleepiness in cognitive functioning of adults with attention deficit hyperactivity disorder

5. Lateralization of attention in adults with ADHD: Evidence of pseudoneglect

6. Emotion recognition and mind wandering in adults with attention deficit hyperactivity disorder or autism spectrum disorder

7. How Does an Observational Assessment Adapted for Online Delivery Perform Compared to an In-Person Assessment? Learning From the National Autism Service for Adults

8. ADHD in adults

9. Lateralization of attention in adults with ADHD: Evidence of pseudoneglect

10. Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans

11. The effects of emotional lability, mind wandering and sleep quality on ADHD symptom severity in adults with ADHD

12. Measurement of $W^{\pm}Z$ production cross sections and gauge boson polarisation in $pp$ collisions at $\sqrt{s} = 13$ TeV with the ATLAS detector

13. A measurement of material in the ATLAS tracker using secondary hadronic interactions in 7 TeV pp collisions

14. Immune signatures and disorder-specific patterns in a cross-disorder gene expression analysis

15. Measurement of the W±Z production cross section and limits on anomalous triple gauge couplings in proton–proton collisions at s=7 TeV with the ATLAS detector

16. ADHD symptom presentation and trajectory in adults with borderline and mild intellectual disability

17. Assessment of mental health problems in people with autism

18. Attention deficit hyperactivity disorder in adults with learning disabilities

19. Attention-Deficit Hyperactivity Disorder (ADHD)

20. Comparison of ICD-10R, DSM-IV-TR and DSM-5 in an adult autism spectrum disorder diagnostic clinic

21. Atomoxetine for Attention Deficit Hyperactivity Disorder (ADHD) in people with intellectual disabilities

22. ADHD in adults. Your guide to today's mental health issues

23. Assessing the impact of risk-taking behavior on road crash involvement among University students residing in two Mediterranean countries

24. Describing the brain in autism in five dimensions--magnetic resonance imaging-assisted diagnosis of autism spectrum disorder using a multiparameter classification approach

25. Risperidone for attention-deficit hyperactivity disorder in people with intellectual disabilities

26. Amfetamine for attention deficit hyperactivity disorder in people with intellectual disabilities

27. The clinical presentation of ADHD in adults with Learning Disability: experience from a National Specialist Adult ADHD clinic

28. Atomoxetine for attention deficit hyperactivity disorder in people with intellectual disabilities

29. Rates of undiagnosed attention deficit hyperactivity disorder in London drug and alcohol detoxification units

30. A Spatiotemporal Profile of In Vivo Cerebral Blood Flow Changes Following Intranasal Oxytocin in Humans

31. Immune signatures and disorder-specific patterns in a cross-disorder gene expression analysis.

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31 results on '"Stefanos Maltezos"'

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