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1. Measurable residual disease quantification in adult patients with KMT2A-rearranged acute lymphoblastic leukemia

Author

Burmeister, Thomas, Ströh, Aeint-Steffen, Kehden, Britta, Trautmann, Heiko, Meyer, Claus, Marschalek, Rolf, Larghero, Patrizia, Schwartz, Stefan, Steffen, Björn, Spriewald, Bernd, Heinicke, Thomas, Jäkel, Nadja, Westermann, Jörg, Nachtkamp, Kathrin, Viardot, Andreas, Topp, Max S., Neumann, Martin, Baldus, Claudia D., Gökbuget, Nicola, and Brüggemann, Monika

Published
2024
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2. Evaluation of a vaccination seminar in regard to medical students' attitudes and their theoretical and practical vaccination-specific competencies

Author

Rill, Vera, Steffen, Björn, and Wicker, Sabine

Subjects
vaccination certificate, immunization seminar, medical students, attitude, knowledge, practical competence, medical education, Special aspects of education, LC8-6691, Medicine
Abstract

Aim: Despite having a generally positive attitude toward vaccinations, medical students show gaps in their own immunization histories and knowledge about vaccinations. Future practicing physicians will be confronted with the need to evaluate protective immunity and make vaccination recommendations. This study aims to investigate the extent to which a seminar on the topic of vaccination can improve students’ attitudes, knowledge and practical skills in interpreting vaccination certificates.Project description: Two different one-hour seminars were developed and integrated into the required clinical curriculum. A third of the students attended a theory-based seminar; the other two-thirds completed a predominantly practice-based seminar. The theoretical seminar consisted of a lecture on the principles and theoretical aspects of immunization. In the practical seminar, the curricular content was case-based and taught using fictive examples of vaccination certificates. Before the seminar was held, a voluntary and anonymous survey of the students was conducted regarding their attitudes toward and knowledge of immunization. At the conclusion of the seminar, the students’ ability to understand vaccination certificates was tested. After completing the seminar, all of the participants received a link to participate in a voluntary online survey to evaluate the seminar.Results: Of the 149 seminar attendees in the 2017/18 winter semester, 148 participated in the study. Students have a positive attitude toward vaccinations. Regardless of the type of seminar attended, the agreement with statements on vaccination could be significantly increased primarily among students who already at the start of the seminar expressed a high degree of agreement. Students vaccinated against influenza showed significantly stronger agreement than unvaccinated students. Regardless of teaching format, students’ knowledge about vaccination topics could be increased. For those vaccinated against influenza, the mean value for agreement with the statement, saw an increase on a five-point Likert scale from 3.97 to 4.4 (p

Published
2020
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3. Cytokine-responsive T- and NK-cells portray SARS-CoV-2 vaccine-responders and infection in multiple myeloma patients

Author

Enssle, Julius C., Campe, Julia, Moter, Alina, Voit, Isabel, Gessner, Alec, Yu, Weijia, Wolf, Sebastian, Steffen, Björn, Serve, Hubert, Bremm, Melanie, Huenecke, Sabine, Lohoff, Michael, Vehreschild, Maria, Rabenau, Holger F., Widera, Marek, Ciesek, Sandra, Oellerich, Thomas, Imkeller, Katharina, Rieger, Michael A., von Metzler, Ivana, and Ullrich, Evelyn

Published
2024
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4. The reliability and predictive validity of a sixth-semester OSPE in conservative dentistry regarding performance on the state examination

Author

Petko, Petkov, Knuth-Herzig, Katja, Hoefer, Sebastian, Stehle, Sebastian, Scherer, Sonja, Steffen, Björn, Scherzer, Stephan, Ochsendorf, Falk, Horz, Holger, Sader, Robert, and Gerhardt-Szép, Susanne

Subjects
OSPE, OSCE, predictive validity, reliability, state exams, length of study, clinical competency, Special aspects of education, LC8-6691, Medicine
Abstract

Introduction: The aim of this study was to ascertain whether the testing format of an OSPE (Objective Structured Practical Examination) in conservative dentistry (sixth semester) predicts the scores on the practical section of the state examination (11 semester) in the same subject. Taking general student profiles into consideration (score on the school-leaving exam [Abitur], score on the preliminary exam in dental medicine [Physikum], length of university study, cohorts, and sex), we also investigated if any correlations or differences exist in regard to the total and partial scores on the OSPE and the corresponding state examination.Methods: Within the scope of this longitudinal retrospective study, exam-specific data spanning 11 semesters for dental students (N=223) in Frankfurt am Main were collected and analyzed. Statistical analysis was carried out by calculating Spearman rank correlations, partial correlations, Pearson’s correlation coefficients, and multiple regressions (SPSS Statistics 21, IBM Corporation, New York).Results: The results show that the OSPE (Cronbach’s α=.87) correlates with level of success on the practical section of the state exam in conservative dentistry (=.01, =.17). Length of university study also emerged to correlate significantly with the state exam score (=.001, =.23). Together, these two variables contribute significantly to predicting the state exam score (=.001, =.076). This was seen extensively among female students. It was also discovered that these female students had higher school-leaving exam scores than male students (=6.09, =.01, =.027), and that a significant correlation between scores on the Physikum (preliminary exam in dental medicine) and OSPE scores existed only for male students (=.17, =.01).Conclusion: This study was able to demonstrate the predictive effect of a clinical OSPE regarding scores achieved on the state exam. Taking the limitations of this study into account, we are able to recommend using the OSPE testing format in the sixth semester during the clinical phase of dental study.

Published
2017
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5. Mutated IKZF1 is an independent marker of adverse risk in acute myeloid leukemia

Author

Eckardt, Jan-Niklas, Stasik, Sebastian, Röllig, Christoph, Petzold, Andreas, Sauer, Tim, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Kunzmann, Volker, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Herbst, Regina, Hänel, Mathias, Hanoun, Maher, Kaiser, Ulrich, Kaufmann, Martin, Rácil, Zdenek, Mayer, Jiri, Oelschlägel, Uta, Berdel, Wolfgang E., Ehninger, Gerhard, Serve, Hubert, Müller-Tidow, Carsten, Platzbecker, Uwe, Baldus, Claudia D., Dahl, Andreas, Schetelig, Johannes, Bornhäuser, Martin, Middeke, Jan Moritz, and Thiede, Christian

Published
2023
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6. Secondary-type mutations do not impact outcome in NPM1-mutated acute myeloid leukemia – implications for the European LeukemiaNet risk classification

Author

Eckardt, Jan-Niklas, Bill, Marius, Rausch, Christian, Metzeler, Klaus, Spiekermann, Karsten, Stasik, Sebastian, Sauer, Tim, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Krug, Utz, Wörmann, Bernhard, Hiddemann, Wolfgang, Görlich, Dennis, Sauerland, Cristina, Steffen, Björn, Einsele, Hermann, Neubauer, Andreas, Burchert, Andreas, Schäfer-Eckart, Kerstin, Berdel, Wolfgang E., Schliemann, Christoph, Krause, Stefan W., Hänel, Mathias, Hanoun, Maher, Kaufmann, Martin, Fransecky, Lars, Braess, Jan, Ruhnke, Leo, Schetelig, Johannes, Middeke, Jan Moritz, Serve, Hubert, Baldus, Claudia D., Platzbecker, Uwe, Müller-Tidow, Carsten, Bornhäuser, Martin, Herold, Tobias, Thiede, Christian, and Röllig, Christoph

Published
2023
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7. Impact of BMI on patient outcome in acute myeloid leukaemia patients receiving intensive induction therapy: a real-world registry experience

Author

Enßle, Julius C., Wolf, Sebastian, Scheich, Sebastian, Weber, Sarah, Kramer, Michael, Ruhnke, Leo, Schliemann, Christoph, Mikesch, Jan-Henrik, Krause, Stefan, Sauer, Tim, Hanoun, Maher, Reinhardt, Hans Christian, Kraus, Sabrina, Kaufmann, Martin, Hänel, Mathias, Fransecky, Lars, Burchert, Andreas, Neubauer, Andreas, Crysandt, Martina, Jost, Edgar, Niemann, Dirk, Schäfer-Eckart, Kerstin, Held, Gerhard, Kaiser, Ulrich, Wass, Maxi, Schaich, Markus, Müller-Tidow, Carsten, Platzbecker, Uwe, Baldus, Claudia D., Bornhäuser, Martin, Röllig, Christoph, Serve, Hubert, and Steffen, Björn

Published
2023
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9. Intensified cytarabine dose during consolidation in adult AML patients under 65 years is not associated with survival benefit: real-world data from the German SAL-AML registry

Author

Hanoun, Maher, Ruhnke, Leo, Kramer, Michael, Hanoun, Christine, Schäfer-Eckart, Kerstin, Steffen, Björn, Sauer, Tim, Krause, Stefan W., Schliemann, Christoph, Mikesch, Jan-Henrik, Kaufmann, Martin, Hänel, Mathias, Jost, Edgar, Brümmendorf, Tim H., Fransecky, Lars, Kraus, Sabrina, Einsele, Hermann, Niemann, Dirk, Neubauer, Andreas, Kullmer, Johannes, Seggewiss-Bernhard, Ruth, Görner, Martin, Held, Gerhard, Kaiser, Ulrich, Scholl, Sebastian, Hochhaus, Andreas, Reinhardt, H. Christian, Platzbecker, Uwe, Baldus, Claudia D., Müller-Tidow, Carsten, Bornhäuser, Martin, Serve, Hubert, and Röllig, Christoph

Published
2023
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10. Remission induction versus immediate allogeneic haematopoietic stem cell transplantation for patients with relapsed or poor responsive acute myeloid leukaemia (ASAP): a randomised, open-label, phase 3, non-inferiority trial

Author

Alakel, Nael, Albring, Jörn, Berdel, Wolfgang E., Bethge, Wolfgang, Bornhäuser, Martin, Bug, Gesine, Buhl, Christoph, Call, Simon, Crysandt, Martina, Egger-Heidrich, Katharina, Eßeling, Eva, Faul, Christoph, Franke, Georg-Nikolaus, Georgi, Julia-Annabell, Glück-Wolf, Julia, Groth, Christoph, Hauptrock, Beate, Heidenreich, Daniela, Janjetovic, Snjezana, Jost, Edgar, Kaufmann, Martin, Kindler, Thomas, Klein, Stefan A., Krause, Stefan W., Kreil, Sebastian, Kretschmann, Theresa, Kunadt, Desiree, Lang, Fabian, Lenz, Georg, Martin, Sonja, Marx, Julia, Middeke, Jan-Moritz, Mikesch, Jan-Henrik, Müller, Lutz P., Müller, Nadine, Niederland, Judith, Parmentier, Stefani, Petzold, Kathrin, Platzbecker, Uwe, Rank, Andreas, Reicherts, Christian, Röllig, Christoph, Rösler, Wolf, Schäfer-Eckart, Kerstin, Schaffrath, Judith, Schaich, Markus, Schetelig, Johannes, Schliemann, Christoph, Schmid, Christoph, Schneidawind, Dominik, Schubert, Jörg, Serve, Hubert, Sockel, Katja, Steffen, Björn, Stelljes, Matthias, Teipel, Raphael, von Bonin, Malte, Wagner-Drouet, Eva, Wass, Maxi, Wendelin, Knut, Middeke, Jan Moritz, Wagner-Drouet, Eva-Maria, Müller, Lutz P, Krause, Stefan W, Klein, Stefan A, Baldauf, Henning, Stölzel, Friedrich, Petzold, Cathleen, Kriege, Oliver, Berdel, Wolfgang E, Ehninger, Gerhard, and Schmidt, Alexander H

Published
2024
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11. Q-HAM: a multicenter upfront randomized phase II trial of quizartinib and high-dose Ara-C plus mitoxantrone in relapsed/refractory AML with FLT3-ITD

Author

Jaramillo, Sonia, Le Cornet, Lucian, Kratzmann, Markus, Krisam, Johannes, Görner, Martin, Hänel, Mathias, Röllig, Christoph, Wass, Maxi, Scholl, Sebastian, Ringhoffer, Mark, Reichart, Alexander, Steffen, Björn, Kayser, Sabine, Mikesch, Jan-Henrik, Schaefer-Eckart, Kerstin, Schubert, Jörg, Geer, Thomas, Martin, Sonja, Kieser, Meinhard, Sauer, Tim, Kriegsmann, Katharina, Hundemer, Michael, Serve, Hubert, Bornhäuser, Martin, Müller-Tidow, Carsten, and Schlenk, Richard F.

Published
2023
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12. UBTF tandem duplications are rare but recurrent alterations in adult AML and associated with younger age, myelodysplasia, and inferior outcome

Author

Georgi, Julia-Annabell, Stasik, Sebastian, Eckardt, Jan-Niklas, Zukunft, Sven, Hartwig, Marita, Röllig, Christoph, Middeke, Jan Moritz, Oelschlägel, Uta, Krug, Utz, Sauer, Tim, Scholl, Sebastian, Hochhaus, Andreas, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Hänel, Mathias, Noppeney, Richard, Kaiser, Ulrich, Baldus, Claudia D., Kaufmann, Martin, Müller-Tidow, Carsten, Platzbecker, Uwe, Berdel, Wolfgang E., Serve, Hubert, Ehninger, Gerhard, Bornhäuser, Martin, Schetelig, Johannes, Kroschinsky, Frank, and Thiede, Christian

Published
2023
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13. Alterations of cohesin complex genes in acute myeloid leukemia: differential co-mutations, clinical presentation and impact on outcome

Author

Eckardt, Jan-Niklas, Stasik, Sebastian, Röllig, Christoph, Sauer, Tim, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Kunzmann, Volker, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Herbst, Regina, Hänel, Mathias, Hanoun, Maher, Kaiser, Ulrich, Kaufmann, Martin, Rácil, Zdenek, Mayer, Jiri, Cerqueira, Tiago, Kroschinsky, Frank, Berdel, Wolfgang E., Serve, Hubert, Müller-Tidow, Carsten, Platzbecker, Uwe, Baldus, Claudia D., Schetelig, Johannes, Siepmann, Timo, Bornhäuser, Martin, Middeke, Jan Moritz, and Thiede, Christian

Published
2023
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16. A randomized phase 2 trial of nintedanib and low-dose cytarabine in elderly patients with acute myeloid leukemia ineligible for intensive chemotherapy

Author

Berdel, Andrew F., Koch, Raphael, Gerss, Joachim, Hentrich, Marcus, Peceny, Rudolf, Bartscht, Tobias, Steffen, Björn, Bischoff, Marina, Spiekermann, Karsten, Angenendt, Linus, Mikesch, Jan-Henrik, Kewitz, Tobias, Butterfass-Bahloul, Trude, Serve, Hubert, Lenz, Georg, Berdel, Wolfgang E., Krug, Utz, and Schliemann, Christoph

Published
2023
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17. German Patient Blood Management Network: effectiveness and safety analysis in 1.2 million patients

Author

Baumhove, Olaf, Leeuw van Weenen, Samuel de, Velten, Markus, Wittmann, Maria, Neumann, Claudia, Kirfel, Andrea, Straßberger-Nerschbach, Nadine, Ehrentraut, Heidi, Grigutsch, Daniel, Guttenthaler, Vera, Puskarevic, Alma, Mohssen, Ghaith, Oldenburg, Johannes, Görtzen, Jan, Narita, Diana, Barbara, Lighvani, Michael Huber, Josef, Choorapoikayil, Suma, Hof, Lotta, Isik, Sabine, Neef, Vanessa, Piekarski, Florian, Schmitt, Elke, Zacharowski, Kai, Walther, Thomas, Keller, Harald, Schnitzbauer, Andreas, Schmitz-Rixen, Thomas, Oikonomou, Kyriakos, Steffen, Bjoern, Zeuzem, Stefan, Czabanka, Marcus, Chun, Felix, Marzi, Ingo, Stöver, Timo, Ghanaati, Shahram, Louwen, Frank, Mueller, Markus M., Geisen, Christoph, Seyfried, Erhard, Herrmann, Eva, Bayer, Alexandra, Weigt, Henry, Lange, Björn, Raadts, Ansgar, Haas, Christoph, Duemmler, Johannes, Lorenzen, Ulf, Pagel, Matthias, Puehler, Thomas, Pochhammer, Julius, Klueter, Tim, Ahmeti, Hajrullah, Bauerschlag, Dirk, Wieker, Henning, Rusch, René, Meybohm, Patrick, Old, Oliver, Müller, Markus M., Geisen, Christof, Seifried, Erhard, de Leeuw van Weenen, Samuel, Friederich, Patrick, Bräutigam, Brigitte, Friedrich, Jens, Gruenewald, Matthias, Elke, Gunnar, Molter, Gerd P., Schwendner, Klaus, Steinbicker, Andrea U., Jenke, Dana J., Thoma, Josef, and Weber, Viola

Published
2023
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18. A post hoc analysis of the EPAZ trial: The role of geriatric variables in elderly soft tissue sarcoma patients on toxicity and outcome

Author

Hamacher, Rainer, Liu, Xiaofei, Schuler, Markus K., Hentschel, Leopold, Schöffski, Patrick, Kopp, Hans-Georg, Bauer, Sebastian, Kasper, Bernd, Lindner, Lars, Chemnitz, Jens-Markus, Crysandt, Martina, Stein, Alexander, Steffen, Björn, Richter, Stephan, Egerer, Gerlinde, Ivanyi, Philipp, Kunitz, Annegret, and Grünwald, Viktor

Published
2023
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20. Developmental trajectories and cooperating genomic events define molecular subtypes of BCR::ABL1-positive ALL

Author

Bastian, Lorenz, primary, Beder, Thomas, additional, Barz, Malwine J., additional, Bendig, Sonja, additional, Bartsch, Lorenz, additional, Walter, Wencke, additional, Wolgast, Nadine, additional, Brändl, Björn, additional, Rohrandt, Christian, additional, Hansen, Björn-Thore, additional, Hartmann, Alina M., additional, Iben, Katharina, additional, Das Gupta, Dennis, additional, Denker, Miriam, additional, Zimmermann, Johannes, additional, Wittig, Michael, additional, Chitadze, Guranda, additional, Neumann, Martin, additional, Schneller, Folker, additional, Fiedler, Walter, additional, Steffen, Björn, additional, Stelljes, Matthias, additional, Faul, Christoph, additional, Schwartz, Stefan, additional, Müller, Franz-Josef, additional, Cario, Gunnar, additional, Harder, Lana, additional, Haferlach, Claudia, additional, Pfeifer, Heike, additional, Gökbuget, Nicola, additional, Brüggemann, Monika, additional, and Baldus, Claudia D., additional

Published
2024
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21. UBTF::ATXN7L3 gene fusion defines novel B cell precursor ALL subtype with CDX2 expression and need for intensified treatment

Author

Bastian, Lorenz, Hartmann, Alina M., Beder, Thomas, Hänzelmann, Sonja, Kässens, Jan, Bultmann, Miriam, Hoeppner, Marc P., Franzenburg, Sören, Wittig, Michael, Franke, Andre, Nagel, Inga, Spielmann, Malte, Reimer, Niklas, Busch, Hauke, Schwartz, Stefan, Steffen, Björn, Viardot, Andreas, Döhner, Konstanze, Kondakci, Mustafa, Wulf, Gerald, Wendelin, Knut, Renzelmann, Andrea, Kiani, Alexander, Trautmann, Heiko, Neumann, Martin, Gökbuget, Nicola, Brüggemann, Monika, and Baldus, Claudia D.

Published
2022
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23. Impact of IDH1 and IDH2 mutational subgroups in AML patients after allogeneic stem cell transplantation

Author

Kunadt, Desiree, Stasik, Sebastian, Metzeler, Klaus H., Röllig, Christoph, Schliemann, Christoph, Greif, Philipp A., Spiekermann, Karsten, Rothenberg-Thurley, Maja, Krug, Utz, Braess, Jan, Krämer, Alwin, Hochhaus, Andreas, Scholl, Sebastian, Hilgendorf, Inken, Brümmendorf, Tim H., Jost, Edgar, Steffen, Björn, Bug, Gesine, Einsele, Hermann, Görlich, Dennis, Sauerland, Cristina, Schäfer-Eckart, Kerstin, Krause, Stefan W., Hänel, Mathias, Hanoun, Maher, Kaufmann, Martin, Wörmann, Bernhard, Kramer, Michael, Sockel, Katja, Egger-Heidrich, Katharina, Herold, Tobias, Ehninger, Gerhard, Burchert, Andreas, Platzbecker, Uwe, Berdel, Wolfgang E., Müller-Tidow, Carsten, Hiddemann, Wolfgang, Serve, Hubert, Stelljes, Matthias, Baldus, Claudia D., Neubauer, Andreas, Schetelig, Johannes, Thiede, Christian, Bornhäuser, Martin, Middeke, Jan M., and Stölzel, Friedrich

Published
2022
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24. Molecular profiling and clinical implications of patients with acute myeloid leukemia and extramedullary manifestations

Author

Eckardt, Jan-Niklas, Stölzel, Friedrich, Kunadt, Desiree, Röllig, Christoph, Stasik, Sebastian, Wagenführ, Lisa, Jöhrens, Korinna, Kuithan, Friederike, Krämer, Alwin, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Kunzmann, Volker, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Herbst, Regina, Hänel, Mathias, Hanoun, Maher, Kaiser, Ulrich, Kaufmann, Martin, Rácil, Zdenek, Mayer, Jiri, Kroschinsky, Frank, Berdel, Wolfgang E., Ehninger, Gerhard, Serve, Hubert, Müller-Tidow, Carsten, Platzbecker, Uwe, Baldus, Claudia D., Schetelig, Johannes, Bornhäuser, Martin, Thiede, Christian, and Middeke, Jan Moritz

Published
2022
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25. Differential impact of IDH1/2 mutational subclasses on outcome in adult AML: results from a large multicenter study

Author

Middeke, Jan M., Metzeler, Klaus H., Röllig, Christoph, Krämer, Michael, Eckardt, Jan-Niklas, Stasik, Sebastian, Greif, Philipp A., Spiekermann, Karsten, Rothenberg-Thurley, Maja, Krug, Utz, Braess, Jan, Krämer, Alwin, Hochhaus, Andreas, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Görlich, Dennis, Sauerland, Cristina, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Hänel, Mathias, Frickhofen, Norbert, Noppeney, Richard, Kaiser, Ulrich, Kaufmann, Martin, Kunadt, Desiree, Wörmann, Bernhard, Sockel, Katja, von Bonin, Malte, Herold, Tobias, Müller-Tidow, Carsten, Platzbecker, Uwe, Berdel, Wolfgang E., Serve, Hubert, Baldus, Claudia D., Ehninger, Gerhard, Schetelig, Johannes, Hiddemann, Wolfgang, Bornhäuser, Martin, Stölzel, Friedrich, and Thiede, Christian

Published
2022
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26. CEBPA mutations in 4708 patients with acute myeloid leukemia: differential impact of bZIP and TAD mutations on outcome

Author

Taube, Franziska, Georgi, Julia Annabell, Kramer, Michael, Stasik, Sebastian, Middeke, Jan Moritz, Röllig, Christoph, Krug, Utz, Krämer, Alwin, Scholl, Sebastian, Hochhaus, Andreas, Brümmendorf, Tim H., Naumann, Ralph, Petzold, Andreas, Mulet-Lazaro, Roger, Valk, Peter J.M., Steffen, Björn, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Hänel, Mathias, Noppeney, Richard, Kaiser, Ulrich, Baldus, Claudia D., Kaufmann, Martin, Herold, Sylvia, Stölzel, Friedrich, Sockel, Katja, von Bonin, Malte, Müller-Tidow, Carsten, Platzbecker, Uwe, Berdel, Wolfgang E., Serve, Hubert, Ehninger, Gerhard, Bornhäuser, Martin, Schetelig, Johannes, and Thiede, Christian

Published
2022
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28. Quizartinib, an FLT3 inhibitor, as monotherapy in patients with relapsed or refractory acute myeloid leukaemia: an open-label, multicentre, single-arm, phase 2 trial

Author

Cortes, Jorge, Perl, Alexander E, Döhner, Hartmut, Kantarjian, Hagop, Martinelli, Giovanni, Kovacsovics, Tibor, Rousselot, Philippe, Steffen, Björn, Dombret, Hervé, Estey, Elihu, Strickland, Stephen, Altman, Jessica K, Baldus, Claudia D, Burnett, Alan, Krämer, Alwin, Russell, Nigel, Shah, Neil P, Smith, Catherine C, Wang, Eunice S, Ifrah, Norbert, Gammon, Guy, Trone, Denise, Lazzaretto, Deborah, and Levis, Mark

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Oncology and Carcinogenesis, Clinical Trials and Supportive Activities, Hematology, Cancer, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Administration, Oral, Adult, Aged, Benzothiazoles, Canada, Disease-Free Survival, Dose-Response Relationship, Drug, Drug Administration Schedule, Europe, Female, Humans, Internationality, Leukemia, Myeloid, Acute, Male, Maximum Tolerated Dose, Middle Aged, Neoplasm Recurrence, Local, Phenylurea Compounds, Prognosis, Survival Rate, Treatment Outcome, United States, Young Adult, fms-Like Tyrosine Kinase 3, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundOld age and FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutations in patients with acute myeloid leukaemia are associated with early relapse and poor survival. Quizartinib is an oral, highly potent, and selective next-generation FLT3 inhibitor with clinical antileukaemic activity in relapsed or refractory acute myeloid leukaemia. We aimed to assess the efficacy and safety of single-agent quizartinib in patients with relapsed or refractory acute myeloid leukaemia.MethodsWe did an open-label, multicentre, single-arm, phase 2 trial at 76 hospitals and cancer centres in the USA, Europe, and Canada. We enrolled patients with morphologically documented primary acute myeloid leukaemia or acute myeloid leukaemia secondary to myelodysplastic syndromes and an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 into two predefined, independent cohorts: patients who were aged 60 years or older with relapsed or refractory acute myeloid leukaemia within 1 year after first-line therapy (cohort 1), and those who were 18 years or older with relapsed or refractory disease following salvage chemotherapy or haemopoietic stem cell transplantation (cohort 2). Patients with an FLT3-ITD allelic frequency of more than 10% were considered as FLT3-ITD positive, whereas all other patients were considered as FLT3-ITD negative. Patients received quizartinib once daily as an oral solution; the initial 17 patients received 200 mg per day but the QTcF interval was prolonged for more than 60 ms above baseline in some of these patients. Subsequently, doses were amended for all patients to 135 mg per day for men and 90 mg per day for women. The co-primary endpoints were the proportion of patients who achieved a composite complete remission (defined as complete remission + complete remission with incomplete platelet recovery + complete remission with incomplete haematological recovery) and the proportion of patients who achieved a complete remission. Efficacy and safety analyses included all patients who received at least one dose of quizartinib (ie, the intention-to-treat population). Patients with a locally assessed post-treatment bone marrow aspirate or biopsy were included in efficacy analyses by response; all other patients were considered to have an unknown response. This study is registered with ClinicalTrials.gov, number NCT00989261, and with the European Clinical Trials Database, EudraCT 2009-013093-41, and is completed.FindingsBetween Nov 19, 2009, and Oct 31, 2011, a total of 333 patients were enrolled (157 in cohort 1 and 176 in cohort 2). In cohort 1, 63 (56%) of 112 FLT3-ITD-positive patients and 16 (36%) of 44 FLT3-ITD-negative patients achieved composite complete remission, with three (3%) FLT3-ITD-positive patients and two (5%) FLT3-ITD-negative patients achieving complete remission. In cohort 2, 62 (46%) of 136 FLT3-ITD-positive patients achieved composite complete remission with five (4%) achieving complete remission, whereas 12 (30%) of 40 FLT3-ITD-negative patients achieved composite complete remission with one (3%) achieving complete remission. Across both cohorts (ie, the intention-to-treat population of 333 patients), grade 3 or worse treatment-related treatment-emergent adverse events in 5% or more of patients were febrile neutropenia (76 [23%] of 333), anaemia (75 [23%]), thrombocytopenia (39 [12%]), QT interval corrected using Fridericia's formula (QTcF) prolongation (33 [10%]), neutropenia (31 [9%]), leucopenia (22 [7%]), decreased platelet count (20 [6%]), and pneumonia (17 [5%]). Serious adverse events occurring in 5% or more of patients were febrile neutropenia (126 [38%] of 333; 76 treatment related), acute myeloid leukaemia progression (73 [22%]), pneumonia (40 [12%]; 14 treatment related), QTcF prolongation (33 [10%]; 32 treatment related), sepsis (25 [8%]; eight treatment related), and pyrexia (18 [5%]; nine treatment related). Notable serious adverse events occurring in less than 5% of patients were torsades de pointes (one [

Published
2018

29. Akute Leukämien

Author

Steffen, Björn, primary, Brunnberg, Uta, additional, Gökbuget, Nicola, additional, and Serve, Hubert, additional

Published
2022
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30. Autoreninnen und Autoren

Author

Ahrens, Marit, primary, Al-Batran, Salah-Eddin, additional, Armbrust, Robert, additional, Banek, Séverine, additional, Becker, Sven, additional, Bergmann, Lothar, additional, Bojunga, Jörg, additional, Brümmendorf, Tim Henrik, additional, Brunnberg, Uta, additional, Bug, Gesine, additional, Burger, Michael, additional, Chromik, Jörg, additional, Chun, Felix K.-H., additional, Czauderna, Carolin, additional, Dumoulin, Franz Ludwig, additional, Dreyling, Martin, additional, El-Balat, Ahmed, additional, Ellinger, Jörg, additional, Elsner, Susanne, additional, Enßle, Julius C., additional, Fottner, Christian, additional, Galle, Peter R., additional, Gökbuget, Nicola, additional, Götze, Thorsten Oliver, additional, Halbsguth, Teresa, additional, Höh, Benedikt, additional, Hohenberger, Peter, additional, Hübner, Joachim, additional, Hübner, Jutta, additional, Isfort, Susanne, additional, Kasper, Bernd, additional, Katalinic, Alexander, additional, Kestler, Angelika, additional, Khodamoradi, Yascha, additional, Kleemann, Johannes, additional, Kluth, Luis A., additional, Köhler, Viktoria F., additional, Kollmar, Otto, additional, Koschmieder, Steffen, additional, Lang, Fabian, additional, Makowka, Philipp, additional, Mallmann, Peter, additional, Mallmann-Gottschalk, Nina, additional, Mandel, Philipp, additional, Maurer, Gabriele, additional, Mayer, Arnulf, additional, Meissner, Markus, additional, Menge, Franka, additional, Middeke, Jan Moritz, additional, Miesbach, Wolfgang, additional, Möhler, Markus, additional, Möbus, Volker, additional, Müller, Stefan C., additional, Musholt, Thomas J., additional, Nauck, Friedemann, additional, Oellerich, Thomas, additional, Özistanbullu, Deniz, additional, Porschen, Rainer, additional, Pox, Christian, additional, Richter, Konrad Klaus, additional, Sauerbruch, Tilman, additional, Scheich, Sebastian, additional, Schetelig, . Johannes, additional, Schmidberger, Heinz, additional, Schnürch, Hans-Georg, additional, Sebastian, Martin, additional, Sehouli, Jalid, additional, Seifart, Ulf, additional, Serve, Hubert, additional, Seufferlein, Thomas, additional, Shaid, Shabnam, additional, Soysal, Savas D., additional, Steffen, Björn, additional, Steinbach, Joachim P., additional, Stratmann, Jan A., additional, Tsoukakis, Ioannis, additional, Ullrich, Evelyn, additional, Vehreschild, Janne, additional, Metzler, Ivana von, additional, Wolff, Michael von, additional, Voß, Martin, additional, Wagner, Sebastian, additional, Weber, Matthias M., additional, Wege, Henning, additional, Weis, Joachim, additional, Welte, Maria-Noemi, additional, Wenzel, Mike, additional, Wolf, Timo, additional, and Zurmeyer, David, additional

Published
2022
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31. No impact of time from diagnosis to treatment on survival in newly diagnosed AML treated with venetoclax-based regimens

Author

Baden, David, primary, Zukunft, Sven, additional, Hernández, Gema, additional, Wolgast, Nadine, additional, Steinhäuser, Sophie, additional, Pohlmann, Alexander, additional, Schliemann, Christoph, additional, Mikesch, Jan-Henrik, additional, Steffen, Björn, additional, Sauer, Tim, additional, Hanoun, Maher, additional, Schäfer-Eckart, Kerstin, additional, Krause, Stefan, additional, Hänel, Mathias, additional, Einsele, Hermann, additional, Jost, Edgar, additional, Brümmendorf, Tim, additional, Scholl, Sebastian, additional, Hochhaus, Andreas, additional, Neubauer, Andreas, additional, Burchert, Andreas, additional, Kaufmann, Martin, additional, Niemann, Dirk, additional, Schaich, Markus, additional, Blau, Wolfgang, additional, Kiani, Alexander, additional, Görner, Martin, additional, Kaiser, Ulrich, additional, Kullmer, Johannes, additional, Weber, Thomas, additional, Berdel, Wolfgang, additional, Ehninger, Gerhard, additional, Müller-Tidow, Carsten, additional, Platzbecker, Uwe, additional, Serve, Hubert, additional, Bornhauser, Martin, additional, Röllig, Christoph, additional, Baldus, Claudia, additional, and Fransecky, Lars, additional

Published
2024
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32. Remission induction versus immediate allogeneic haematopoietic stem cell transplantation for patients with relapsed or poor responsive acute myeloid leukaemia (ASAP): a randomised, open-label, phase 3, non-inferiority trial

Author

Stelljes, Matthias, Middeke, Jan Moritz, Bug, Gesine, Wagner-Drouet, Eva-Maria, Müller, Lutz P, Schmid, Christoph, Krause, Stefan W, Bethge, Wolfgang, Jost, Edgar, Platzbecker, Uwe, Klein, Stefan A, Schubert, Jörg, Niederland, Judith, Kaufmann, Martin, Schäfer-Eckart, Kerstin, Schaich, Markus, Baldauf, Henning, Stölzel, Friedrich, Petzold, Cathleen, Röllig, Christoph, Alakel, Nael, Steffen, Björn, Hauptrock, Beate, Schliemann, Christoph, Sockel, Katja, Lang, Fabian, Kriege, Oliver, Schaffrath, Judith, Reicherts, Christian, Berdel, Wolfgang E, Serve, Hubert, Ehninger, Gerhard, Schmidt, Alexander H, Bornhäuser, Martin, Mikesch, Jan-Henrik, Schetelig, Johannes, Alakel, Nael, Albring, Jörn, Berdel, Wolfgang E., Bethge, Wolfgang, Bornhäuser, Martin, Bug, Gesine, Buhl, Christoph, Call, Simon, Crysandt, Martina, Egger-Heidrich, Katharina, Eßeling, Eva, Faul, Christoph, Franke, Georg-Nikolaus, Georgi, Julia-Annabell, Glück-Wolf, Julia, Groth, Christoph, Hauptrock, Beate, Heidenreich, Daniela, Janjetovic, Snjezana, Jost, Edgar, Kaufmann, Martin, Kindler, Thomas, Klein, Stefan A., Krause, Stefan W., Kreil, Sebastian, Kretschmann, Theresa, Kunadt, Desiree, Lang, Fabian, Lenz, Georg, Martin, Sonja, Marx, Julia, Middeke, Jan-Moritz, Mikesch, Jan-Henrik, Müller, Lutz P., Müller, Nadine, Niederland, Judith, Parmentier, Stefani, Petzold, Kathrin, Platzbecker, Uwe, Rank, Andreas, Reicherts, Christian, Röllig, Christoph, Rösler, Wolf, Schäfer-Eckart, Kerstin, Schaffrath, Judith, Schaich, Markus, Schetelig, Johannes, Schliemann, Christoph, Schmid, Christoph, Schneidawind, Dominik, Schubert, Jörg, Serve, Hubert, Sockel, Katja, Steffen, Björn, Stelljes, Matthias, Teipel, Raphael, von Bonin, Malte, Wagner-Drouet, Eva, Wass, Maxi, and Wendelin, Knut

Abstract

Whether high-dose cytarabine-based salvage chemotherapy, administered to induce complete remission in patients with poor responsive or relapsed acute myeloid leukaemia scheduled for allogeneic haematopoietic stem-cell transplantation (HSCT) after intensive conditioning confers a survival advantage, is unclear.

Published
2024
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33. Impact of PTPN11 mutations on clinical outcome analyzed in 1529 patients with acute myeloid leukemia

Author

Stasik, Sebastian, Eckardt, Jan-Niklas, Kramer, Michael, Röllig, Christoph, Krämer, Alwin, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Kunzmann, Volker, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan, Herbst, Regina, Hänel, Mathias, Frickhofen, Norbert, Noppeney, Richard, Kaiser, Ulrich, Baldus, Claudia D., Kaufmann, Martin, Rácil, Zdenek, Platzbecker, Uwe, Berdel, Wolfgang E., Mayer, Jiri, Serve, Hubert, Müller-Tidow, Carsten, Ehninger, Gerhard, Bornhäuser, Martin, Schetelig, Johannes, Middeke, Jan M., and Thiede, Christian

Published
2021
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37. Deep learning predicts therapy-relevant genetics in acute myeloid leukemia from Pappenheim-stained bone marrow smears

Author

Kockwelp, Jacqueline, primary, Thiele, Sebastian, additional, Bartsch, Jannis, additional, Haalck, Lars, additional, Gromoll, Jörg, additional, Schlatt, Stefan, additional, Exeler, Rita, additional, Bleckmann, Annalen, additional, Lenz, Georg, additional, Wolf, Sebastian, additional, Steffen, Björn, additional, Berdel, Wolfgang E., additional, Schliemann, Christoph, additional, Risse, Benjamin, additional, and Angenendt, Linus, additional

Published
2023
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38. Cytokine-responsive T- and NK-cells portray SARS-CoV-2 vaccine-responders and infection in multiple myeloma patients

Author

Enssle, Julius C., primary, Campe, Julia, additional, Moter, Alina, additional, Voit, Isabel, additional, Gessner, Alec, additional, Yu, Weijia, additional, Wolf, Sebastian, additional, Steffen, Björn, additional, Serve, Hubert, additional, Bremm, Melanie, additional, Huenecke, Sabine, additional, Lohoff, Michael, additional, Vehreschild, Maria, additional, Rabenau, Holger F., additional, Widera, Marek, additional, Ciesek, Sandra, additional, Oellerich, Thomas, additional, Imkeller, Katharina, additional, Rieger, Michael A., additional, von Metzler, Ivana, additional, and Ullrich, Evelyn, additional

Published
2023
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39. Use of carbapenems and glycopeptides increases risk for Clostridioides difficile infections in acute myeloid leukemia patients undergoing intensive induction chemotherapy

Author

Ballo, Olivier, Kreisel, Eva-Maria, Eladly, Fagr, Brunnberg, Uta, Stratmann, Jan, Hunyady, Peter, Hogardt, Michael, Wichelhaus, Thomas A., Kempf, Volkhard A. J., Steffen, Björn, Vehreschild, Joerg J., Vehreschild, Maria J. G. T., Finkelmeier, Fabian, Serve, Hubert, and Brandts, Christian H.

Published
2020
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40. Low-dose melphalan in elderly patients with relapsed or refractory acute myeloid leukemia: A well-tolerated and effective treatment after hypomethylating-agent failure

Author

Stratmann, Jan, van Kann, Elisabeth, Rummelt, Christoph, Koschade, Sebastian, Röllig, Christoph, Lübbert, Michael, Schaich, Markus, Parmentier, Stefani, Sebastian, Martin, Chromik, Joerg, Becker von Rose, Aaron, Ballo, Olivier, Steffen, Björn, Serve, Hubert, Brandts, Christian, and Shaid, Shabnam

Published
2019
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41. PB2070: IMMUNE RESPONSES AFTER SARS-COV-2 MRNA-VACCINATION AND INFECTION AT SINGLE CELL RESOLUTION IN PATIENTS WITH MULTIPLE MYELOMA

Author

Enssle, Julius C., primary, Campe, Julia, additional, Moter, Alina, additional, Voit, Isabel, additional, Gessner, Alec, additional, Yu, Ika Weija, additional, Wolf, Sebastian, additional, Steffen, Björn, additional, Oellerich, Thomas, additional, Serve, Hubert, additional, Bremm, Melanie, additional, Huenecke, Sabine, additional, Lohoff, Michael, additional, Vehreschild, Maria, additional, Rabenau, Holger F, additional, Widera, Marek, additional, Ciesek, Sandra, additional, Rieger, Michael A, additional, Imkeller, Katharina, additional, von Metzler, Ivana, additional, and Ullrich, Evelyn, additional

Published
2023
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42. P355: FAVORABLE OUTCOME OF PHILADELPHIA-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA WITH IMATINIB, DOSE-REDUCED INDUCTION FOLLOWED BY ALLOGENEIC STEM CELL TRANSPLANTATION –RESULTS FROM THE GMALL TRIAL 08/13

Author

Pfeifer, Heike, primary, Lang, Fabian, additional, Fiedler, Walter, additional, Stelljes, Matthias, additional, Schneller, Folker, additional, Steffen, Björn, additional, Böll, Boris, additional, Viardot, Andreas, additional, Faul, Christoph, additional, Lars Teichmann, Lino, additional, Poeck, Hendrik, additional, Westermann, Jörg, additional, Schaefer-Eckart, Kerstin, additional, Heinicke, Thomas, additional, Serve, Hubert, additional, Brüggemann, Monika, additional, Schwartz, Stefan, additional, Burmeister, Thomas, additional, and Gökbuget, Nicola, additional

Published
2023
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43. S138: VALIDATION OF THE REVISED 2022 EUROPEAN LEUKEMIANET (ELN) RISK STRATIFICATION IN ADULT PATIENTS WITH ACUTE MYELOID LEUKEMIA

Author

Bill, Marius, primary, Ruhnke, Leo, additional, Zukunft, Sven, additional, Schäfer, Silvia, additional, Eckardt, Jan-Niklas, additional, Stasik, Sebastian, additional, Hanoun, Maher, additional, Schroeder, Thomas, additional, Fransecky, Lars, additional, Steffen, Björn, additional, Krause, Stefan W., additional, Scholl, Sebastian, additional, Hochhaus, Andreas, additional, Sauer, Tim, additional, Kraus, Sabrina, additional, Schäfer-Eckart, Kerstin, additional, Kaufmann, Martin, additional, Jost, Edgar, additional, Brümmendorf, Tim H, additional, Schliemann, Christoph, additional, Mikesch, Jan-Henrik, additional, Krug, Utz, additional, Hänel, Mathias, additional, Morgner, Anke, additional, Schaich, Markus, additional, Neubauer, Andreas, additional, Repp, Roland, additional, Niemann, Dirk, additional, Seggewiss-Bernhardt, Ruth, additional, Meinhardt, Achim, additional, Kullmer, Johannes, additional, Kaiser, Ulrich, additional, Blau, Wolfgang, additional, Kiani, Alexander, additional, Grigoleit, Götz Ulrich, additional, Giagounidis, Aristoteles, additional, Wurm, Alexander, additional, Altmann, Heidi, additional, Middeke, Jan Moritz, additional, Schetelig, Johannes, additional, Müller-Tidow, Carsten, additional, Stölzel, Friedrich, additional, Baldus, Claudia, additional, Platzbecker, Uwe, additional, Serve, Hubert, additional, Bornhäuser, Martin, additional, Thiede, Christian, additional, and Röllig, Christoph, additional

Published
2023
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