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Your search keyword '"Steffy, Brian M."' showing total 7 results
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7 results on '"Steffy, Brian M."'

3. Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop

Author

Durkin, John T., Holskin, Beverly P., Kopec, Karla K., Reed, Matt S., Spais, Chrysanthe M., Steffy, Brian M., Gessner, George, Angeles, Thelma S., Pohl, Jan, Ator, Mark A., and Meyer, Sheryl L.

Subjects
Threonine -- Chemical properties, Protein kinases -- Research, Phosphorylation -- Methods, Biological sciences, Chemistry
Abstract

Mixed-lineage kinase 1 (MLK1) is a mitogen-activated protein kinase kinase kinase capable of activating the c-Jun NH2-terminal kinase (JNK) pathway. Immunoblot and mass spectrometry show that MLK1 is threonine phosphorylated in or near the activation loop. A kinase dead mutant is not, consistent with autophosphorylation.

Published
2004

4. Identification of QTL for locomotor activation and anxiety using closely-related inbred strains

Author

Bailey, Janice S., Grabowski-Boase, Laura, Steffy, Brian M., Wiltshire, Tim, Churchill, Gary A., and Tarantino, Lisa M.

Subjects
Male, Chromosome Mapping, Mice, Inbred Strains, Anxiety, Motor Activity, Polymorphism, Single Nucleotide, Article, Mice, Inbred C57BL, Mice, Ethylnitrosourea, Animals, Regression Analysis, Female, Mutagens
Abstract

We carried out a quantitative trait loci (QTL) mapping experiment in two phenotypically similar inbred mouse strains, C57BL/6J and C58/J, using the open-field assay, a well-established model of anxiety-related behavior in rodents. This intercross was initially carried out as a control cross for an ethylnitrosurea mutagenesis mapping study. Surprisingly, although open-field behavior is similar in the two strains, we identified significant QTL in their F2 progeny. Marker regression identified a locus on Chr 8 having associations with multiple open-field measures and a significant interaction between loci on Chr 13 and 17. Together, the Chr 8 locus and the interaction effect form the core set of QTL controlling these behaviors with additional loci on Chr 1 and 6 present in a subset of the behaviors.

Published
2008

6. Genome Wide Analysis of Inbred Mouse Lines Identifies a Locus Containing Ppar-γ as Contributing to Enhanced Malaria Survival

Author

Bopp, Selina E. R., primary, Ramachandran, Vandana, additional, Henson, Kerstin, additional, Luzader, Angelina, additional, Lindstrom, Merle, additional, Spooner, Muriel, additional, Steffy, Brian M., additional, Suzuki, Oscar, additional, Janse, Chris, additional, Waters, Andrew P., additional, Zhou, Yingyao, additional, Wiltshire, Tim, additional, and Winzeler, Elizabeth A., additional

Published
2010
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7. A Forward Genetics Screen in Mice Identifies Recessive Deafness Traits and Reveals That Pejvakin Is Essential for Outer Hair Cell Function

Author

Schwander, Martin, primary, Sczaniecka, Anna, additional, Grillet, Nicolas, additional, Bailey, Janice S., additional, Avenarius, Matthew, additional, Najmabadi, Hossein, additional, Steffy, Brian M., additional, Federe, Glenn C., additional, Lagler, Erica A., additional, Banan, Raheleh, additional, Hice, Rudy, additional, Grabowski-Boase, Laura, additional, Keithley, Elisabeth M., additional, Ryan, Allen F., additional, Housley, Gary D., additional, Wiltshire, Tim, additional, Smith, Richard J. H., additional, Tarantino, Lisa M., additional, and Müller, Ulrich, additional

Published
2007
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