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10. Feasibility and safety of intranasally administered mesenchymal stromal cells after perinatal arterial ischaemic stroke in the Netherlands (PASSIoN): a first-in-human, open-label intervention study

Author

Baak, Lisanne M, Wagenaar, Nienke, van der Aa, Niek E, Groenendaal, Floris, Dudink, Jeroen, Tataranno, Maria Luisa, Mahamuud, Ubah, Verhage, Cornelia H, Eijsermans, Rian M J C, Smit, Liesbeth S, Jellema, Reint K, de Haan, Timo R, ter Horst, Hendrik J, de Boode, Willem P, Steggerda, Sylke J, Prins, Henk-Jan, de Haar, Colin G, de Vries, Linda S, van Bel, Frank, Heijnen, Cobi J, Nijboer, Cora H, and Benders, Manon J N L

Published
2022
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11. Cerebral Doppler imaging in neonates: A guide for clinical application and diagnosis.

Author

Horsch, Sandra, Schwarz, Simone, Arnaez, Juan, Steggerda, Sylke, Arena, Roberta, Govaert, Paul, Agut, Thais, Alarcon, Ana, Bartocci, Marco, Benavente‐Fernández, Isabel, Bravo, Maria Carmen, Cabañas, Fernando, Carreras, Nuria Blesa, Claris, Olivier, Dudink, Jeroen, Fumagalli, Monica, Garcia‐Alix, Alfredo, Lubián‐López, Simón Pedro, Mühlbacher, Tobias, and Parodi, Alessandro

Subjects
MAGNETIC resonance angiography, MAGNETIC resonance imaging, NEONATAL intensive care units, DOPPLER ultrasonography, MAGNETIC resonance
Abstract

Cranial ultrasound reliably diagnoses many neonatal brain disorders. Adding Doppler imaging expands the spectrum by providing information on the status of the vasculature and haemodynamics that may guide further diagnostic and clinical management. Doppler imaging may identify neonates with congenital or acquired vascular abnormalities such as perinatal stroke, sinuvenous thrombosis, vein of Galen malformation, dural sinus malformation, sinus pericranii, and developmental venous anomaly. These entities may need further investigation with complementary imaging modalities such as magnetic resonance imaging and magnetic resonance angiography, or conventional angiography. This review aims to help clinicians to improve their Doppler sonography knowledge and skills in order to use this helpful tool in neonates with neurological symptoms or suspected cerebral vascular abnormalities admitted to the neonatal intensive care unit. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Brain MRI Injury Patterns across Gestational Age among Preterm Infants with Perinatal Asphyxia

Author

Parmentier, Corline E.J., primary, el Bakkali, Loubna, additional, Verhagen, Elise A., additional, Steggerda, Sylke J., additional, Alderliesten, Thomas, additional, Lequin, Maarten H., additional, van de Pol, Laura A., additional, Benders, Manon J.N.L., additional, van Bel, Frank, additional, Koopman-Esseboom, Corine, additional, de Haan, Timo R., additional, de Vries, Linda S., additional, and Groenendaal, Floris, additional

Published
2024
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28. Cerebral imaging and neurodevelopmental outcome after entero- and human parechovirus sepsis in young infants.

Author

de Jong, Eveline, Holscher, Herma, Steggerda, Sylke, Van Klink, Jeanine, van Elzakker, Erika, Lopriore, Enrico, Walther, Frans, and Brus, Frank

Subjects
Cerebral imaging, Enterovirus, Human parechovirus, Neurodevelopment, Brain, Child Development, Enterovirus Infections, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Magnetic Resonance Imaging, Male, Neurodevelopmental Disorders, Neuroimaging, Parechovirus, Picornaviridae Infections, Prospective Studies, Sepsis, Ultrasonography
Abstract

UNLABELLED: Enterovirus (EV) and human parechovirus (HPeV) are major causes of sepsis-like illness in infants under 90 days of age and have been identified as neurotropic. Studies about acute and long-term neurodevelopment in infants with sepsis-like illness without the need for intensive care are few. This study investigates cerebral imaging and neurodevelopmental outcome following EV and HPeV infection in these infants. We studied infants under 90 days of age who were admitted to a medium care unit with proven EV- or HPeV-induced sepsis-like illness. In addition to standard care, we did a cerebral ultrasound and cerebral magnetic resonance imaging (MRI), as well as neurodevelopmental follow-up at 6 weeks and 6 months and Bayley Scale of Infant and Toddler Development 3rd edition (BSID-III) investigation at 1 year of age. Twenty-six infants, 22 with EV and 4 with HPeV, were analysed. No abnormalities were detected at cerebral imaging. At 1 year of age, two infants had a moderate delay on both the motor and cognitive scale, one on the cognitive scale only and three others on the gross motor scale only. CONCLUSION: Although our study population, especially the number of HPeV positive infants is small, our study shows that these infants do not seem to develop severe neurodevelopmental delay and neurologic sequelae more often than the normal Dutch population. Follow-up to school age allows for more reliable assessments of developmental outcome and is recommended for further studies to better assess outcome. What is known: • Enterovirus and Human Parechovirus infections are a major cause of sepsis-like illness in young infants. • After intensive care treatment for EV or HPeV infection, white matter abnormalities and neurodevelopmental delay have been described. What is new: • In our medium care population, no abnormalities at cerebral imaging after EV- or HPeV-induced sepsis-like illness have been found. • At 1 year of age, infants who had EV- or HPeV-induced sepsis-like illness do not seem to develop severe neurodevelopmental delay and neurologic sequelae more often than the normal population.

Published
2017

30. Developmental anatomy of the thalamus, perinatal lesions, and neurological development.

Author

Govaert, Paul, Arena, Roberta, Dudink, Jeroen, Steggerda, Sylke, Agut, Thais, Marissens, Gertjan, Hoebeek, Freek, Thais, Agut, Alarcon, Ana, Arnaez, Juan, Bartocci, Marco, Benavente‐Fernández, Isabel, Bravo, Maria Carmen, Cabañas, Fernando, Carreras, Nuria Blesa, Claris, Olivier, Fumagalli, Monica, Garcia‐Alix, Alfredo, Horsch, Sandra, and Lubián‐López, Simón Pedro

Abstract

The thalamic nuclei develop before a viable preterm age. GABAergic neuronal migration is especially active in the third trimester. Thalamic axons meet cortical axons during subplate activation and create the definitive cortical plate in the second and third trimesters. Default higher‐order cortical driver connections to the thalamus are then replaced by the maturing sensory networks, in a process that is driven by first‐order thalamic neurons. Surface electroencephalographic activity, generated first in the subplate and later in the cortical plate, gradually show oscillations based on the interaction of the cortex with thalamus, which is controlled by the thalamic reticular nucleus. In viable newborn infants, in addition to sensorimotor networks, the thalamus already contributes to visual, auditory, and pain processing, and to arousal and sleep. Isolated thalamic lesions may present as clinical seizures. In addition to asphyxia and stroke, infection and network injury are also common. Cranial ultrasound can be used to classify neonatal thalamic injuries based on functional parcelling of the mature thalamus. We provide ample illustration and a detailed description of the impact of neonatal focal thalamic injury on neurological development, and discuss the potential for neuroprotection based on thalamocortical plasticity. [ABSTRACT FROM AUTHOR]

Published
2025
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31. Neuroimaging in infants with congenital cytomegalovirus infection and its correlation with outcome: emphasis on white matter abnormalities

Author

MS Neonatologie, Alarcón, Ana, de Vries, Linda S, Parodi, Alessandro, Arnáez, Juan, Cabañas, Fernando, Steggerda, Sylke J, Rebollo, Mónica, Ramenghi, Luca, Dorronsoro, Izaskun, López-Azorín, Manuela, Schneider, Juliane, Noguera-Julian, Antoni, Ríos-Barnés, María, Recio, Manuel, Bickle-Graz, Myriam, Martínez-Biarge, Miriam, Fortuny, Clàudia, García-Alix, Alfredo, Truttmann, Anita C, MS Neonatologie, Alarcón, Ana, de Vries, Linda S, Parodi, Alessandro, Arnáez, Juan, Cabañas, Fernando, Steggerda, Sylke J, Rebollo, Mónica, Ramenghi, Luca, Dorronsoro, Izaskun, López-Azorín, Manuela, Schneider, Juliane, Noguera-Julian, Antoni, Ríos-Barnés, María, Recio, Manuel, Bickle-Graz, Myriam, Martínez-Biarge, Miriam, Fortuny, Clàudia, García-Alix, Alfredo, and Truttmann, Anita C

Published
2024

32. Randomized Controlled Early versus Late Ventricular Intervention Study in Posthemorrhagic Ventricular Dilatation: Outcome at 2 Years

Author

Han, Kuo S., ter Horst, Hendrik J., Dijkman, Koen P., Ley, David, Fellman, Vineta, de Haan, Timo R., Brouwer, Annemieke J., Benders, Manon J.N.L., Dudink, Jeroen, Verlaat, Ellen van’t, Govaert, Paul, Swarte, Renate M.C., Rijken, Monique, van Wezel-Meijler, Gerda, Quijano, Thais Agut, Barcik, Uli, Mathur, Amit M., Graca, Andre M., Cizmeci, Mehmet N., Groenendaal, Floris, Liem, Kian D., van Haastert, Ingrid C., Benavente-Fernández, Isabel, van Straaten, Henrica L.M., Steggerda, Sylke, Smit, Bert J., Whitelaw, Andrew, Woerdeman, Peter, Heep, Axel, and de Vries, Linda S.

Published
2020
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33. Association between seizures and neurodevelopmental outcome at two- and five years in asphyxiated newborns with therapeutic hypothermia

Author

Langeslag, J.F., primary, Onland, W., additional, Groenendaal, F., additional, de Vries, L.S., additional, van Kaam, A.H., additional, de Haan, T.R., additional, van den Akker, Chris H.P., additional, de Boode, Willem P., additional, Cools, Filip, additional, ter Horst, Henk J., additional, Dijkman, Koen P., additional, Groenendaal, Floris, additional, de Haan, Timo R., additional, Simons, Sinno H.P., additional, Steggerda, Sylke J., additional, Mulder-Tollenaer, Suzanne, additional, and Zecic, Alexandra, additional

Published
2024
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36. Putting genome-wide sequencing in neonates into perspective

Author

van der Sluijs, Pleuntje J., Aten, Emmelien, Barge-Schaapveld, Daniela Q.C.M., Bijlsma, Emilia K., Bökenkamp-Gramann, Regina, Donker Kaat, Laura, van Doorn, Remco, van de Putte, Dietje Fransen, van Haeringen, Arie, ten Harkel, Arend D.J., Hilhorst-Hofstee, Yvonne, Hoffer, Mariette J.V., den Hollander, Nicolette S., van Ierland, Yvette, Koopmans, Marije, Kriek, Marjolein, Moghadasi, Setareh, Nibbeling, Esther A.R., Peeters-Scholte, Cacha M.P.C.D., Potjer, Thomas P., van Rij, Maartje, Ruivenkamp, Claudia A.L., Rutten, Julie W., Steggerda, Sylke J., Suerink, Manon, Tan, Ratna N.G.B., van der Tuin, Karin, Visser, Remco, van der Werf -'t Lam, Anne-Sophie, Williams, Monique, Witlox, Ruben, and Santen, Gijs W.E.

Published
2019
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37. Assessment of Brain Injury and Brain Volumes after Posthemorrhagic Ventricular Dilatation: A Nested Substudy of the Randomized Controlled ELVIS Trial

Author

Han, K., Woerdeman, P., ter Horst, H.J., Dijkman, K.P., Ley, D., Fellman, V., de Haan, T.R., Brouwer, A.J., van ‘t Verlaat, E., Govaert, P., Smit, B.J., Agut Quijano, T., Barcik, U., Mathur, A., Graca, A.M., Cizmeci, Mehmet N., Khalili, Nadieh, Claessens, Nathalie H.P., Groenendaal, Floris, Liem, Kian D., Heep, Axel, Benavente-Fernández, Isabel, van Straaten, Henrica L.M., van Wezel-Meijler, Gerda, Steggerda, Sylke J., Dudink, Jeroen, Išgum, Ivana, Whitelaw, Andrew, Benders, Manon J.N.L., and de Vries, Linda S.

Published
2019
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38. Social-emotional and behavioural issues after very preterm birth: Parental and teachers experiences.

Author

Jansen, Lisette, Steggerda, Sylke, Rijken, Monique, van Steenis, Andrea, de Vries, Linda, Peeters-Scholte, Cacha, Vermeiren, Robert, and van Klink, Jeanine

Abstract

Preterm infants are at risk of developing social-emotional and behavioural difficulties. To understand the experiences of their caregivers in day-to-day life, parents (at 2 and 10 years) and teachers (at 10 years) completed a behavioural questionnaire and answered two open-ended questions addressing their concerns and the most positive aspects regarding their child and/or pupil (born <32 weeks gestation). Their answers were analyzed using thematic content analysis. Parental concerns at two years related equally to themes in the clusters Developmental Milestones, Physical Development and Development in Relation to the Self and Others. At 10 years, both parents and teachers reported mainly within the cluster Development in Relation to the Self and Others, but the underlying themes differed. While parents more often mentioned their child's emotional development, teachers were more concerned about their pupils' difficulties interacting with their peers, due to a lack of social skills. In-depth qualitative analysis of what parents and teachers experience from day-to-day improves our understanding of the social-emotional and behavioural development of children born very preterm, revealing important topics that should be addressed during follow-up. [ABSTRACT FROM AUTHOR]

Published
2024
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41. List of Contributors

Author

Acharya, Ganesh, primary, Aertsen, Michael, additional, Afshar, Yalda, additional, Ananth, Cande V., additional, Ashworth, Michael, additional, Au, Patrick, additional, Bakalis, Spyros, additional, Benoist, Guillaume, additional, Bilancia, Colleen G., additional, Bilardo, Caterina M., additional, Bryant, Louise D., additional, Butler, Colin R., additional, Van Calenbergh, Frank, additional, Caritis, Steve N., additional, Chitty, Lyn S., additional, Collins, Patricia, additional, Cook, James, additional, Cuckle, Howard, additional, David, Anna L., additional, De Catte, Luc, additional, De Coppi, Paolo, additional, de Jong-Pleij, Elisabeth, additional, De Keersmaecker, Bart, additional, Deprest, Jan, additional, Devlieger, Roland, additional, de Wert, Guido M., additional, Dickinson, Jan E., additional, Dilworth, Mark, additional, Dondorp, Wybo J., additional, Dunk, Caroline E., additional, Everett, Thomas R., additional, Fisher, Jane, additional, Galan, Henry L., additional, Ganapathi, Mythily, additional, Gardiner, Helena M., additional, Gotherstrom, Cecilia, additional, Harding, Richard, additional, Hewison, Jenny, additional, Hewitt, Richard J., additional, Hiersch, Liran, additional, Hill, Melissa, additional, Hillman, Sara L., additional, Hindryckx, An, additional, Hooper, Stuart B., additional, Huppertz, Berthold, additional, Hutchinson, J. Ciaran, additional, Hyett, Jon, additional, Joyeux, Luc, additional, Jurkovic, Davor, additional, Kingdom, John C., additional, Langlois, Sylvie, additional, Lemon, Lara S., additional, Leruez-Ville, Marianne, additional, Lewi, Liesbeth, additional, Levy, Brynn, additional, Loke, Y.W., additional, Lopriore, Enrico, additional, Macones, George A., additional, Malone, Fergal D., additional, Martirosian, Anahit, additional, McAuliffe, Fionnuala, additional, McDougall, Annie R.A., additional, Moise, Kenneth J., additional, Moffett, Ashley, additional, Müllers, Sieglinde M., additional, Neiger, Ran, additional, Newnham, John P., additional, Obican, Sarah G., additional, Odibo, Anthony O., additional, Oepkes, Dick, additional, Pandya, Pranav P., additional, Platt, Lawrence D., additional, Pratt, Rosalind, additional, Rajah, Kuhan, additional, Rao, Rashmi, additional, Richter, Jute, additional, Rosenbloom, Joshua I., additional, Russo, Francesca Maria, additional, Scialli, Anthony R., additional, Sebire, Neil J., additional, Sharkey, Andrew, additional, Shelmerdine, Susan C., additional, Sibley, Colin, additional, Snowise, Saul, additional, Steggerda, Sylke, additional, Su, Emily J., additional, Tang, Mary, additional, Te Pas, Arjan B., additional, Tita, Alan T., additional, Ushakov, Fred, additional, Van den Veyver, Ignatia B., additional, van Klink, Jeanine M., additional, Venkataramanan, Raman, additional, Ville, Yves, additional, Walkiewicz, Magdalena, additional, Wallis, Colin, additional, Walther-Jallow, Lilian, additional, Wapner, Ronald J., additional, Westgren, Magnus, additional, White, Scott W., additional, Wilson, Louise C., additional, Wilson, R. Douglas, additional, Winkelhorst, Dian, additional, Winyard, Paul J.D., additional, Wohlmuth, Christoph, additional, Wou, Karen, additional, Yaron, Yuval, additional, Leung, Kwok Yin, additional, and Yulia, Angela, additional

Published
2020
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43. Correction: Putting genome-wide sequencing in neonates into perspective

Author

van der Sluijs, Pleuntje J., Aten, Emmelien, Barge-Schaapveld, Daniela Q. C. M., Bijlsma, Emilia K., Bökenkamp-Gramann, Regina, Kaat, Laura Donker, van Doorn, Remco, van de Putte, Dietje Fransen, van Haeringen, Arie, ten Harkel, Arend D. J., Hilhorst-Hofstee, Yvonne, Hoffer, Mariette J. V., den Hollander, Nicolette S., van Ierland, Yvette, Koopmans, Marije, Kriek, Marjolein, Moghadasi, Setareh, Nibbeling, Esther A. R., Peeters-Scholte, Cacha M. P. C. D., Potjer, Thomas P., van Rij, Maartje, Ruivenkamp, Claudia A. L., Rutten, Julie W., Steggerda, Sylke J., Suerink, Manon, Tan, Ratna N. G. B., van der Tuin, Karin, Visser, Remco, van der Werf –’t Lam, Anne-Sophie, Williams, Monique, Witlox, Ruben, and Santen, Gijs W. E.

Published
2019
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45. Proceedings of the 14th International Newborn Brain Conference: Neonatal Neurocritical Care, seizures, and continuous aEEG and /or EEG monitoring

Author

Abramsky, Ramy, primary, Acun, Ceyda, additional, Alt, Jesse, additional, Aly, Hany, additional, Arad, Noa, additional, Baak, Lisanne M., additional, Bakalar, Dana, additional, Balasingham, Thameya, additional, Bammler, Theo, additional, Benders, Manon J.N.L., additional, Benitez, Diana, additional, Boni, Elisa, additional, Boylan, Geraldine, additional, Campbell, Ellie, additional, Castri, Paola, additional, Chandrashekar, Priyanka, additional, Chavez-Valdez, Raul, additional, Chen, May, additional, Chiodin, Elisabetta, additional, Comstock, Bryan, additional, Damien, Janie, additional, de Vries, Linda S., additional, de Vries, Linda, additional, Dickman, Jacky, additional, Doucette, Leslie, additional, Duckworth, Ellie, additional, Echeverria-Palacio, Carlos, additional, El Jalbout, Ramy, additional, El-Dib, Mohamed, additional, Elshibiny, Hoda, additional, Flock, Debbie, additional, Gallagher, Anne, additional, Gasperoni, Enrica, additional, Glass, Hannah, additional, Harteman, Johanneke C., additional, Harvey-Jones, Kelly, additional, Hazan, Itay, additional, Heagerty, Patrick, additional, Inder, Terrie, additional, Jantzie, Lauren, additional, Juul, Sandra, additional, Karnati, Sreenivas, additional, Kute, Nazli, additional, Lacaille, Helene, additional, Lange, Frederic, additional, Lemmers, Petra M.A., additional, Liu, Wei, additional, Llaguno, Nathalie, additional, Magalhães, Mauricio, additional, Mambule, Ivan, additional, Marandyuk, Bohdana, additional, Marks, Kyla, additional, Martin, Lee J., additional, Massaro, An, additional, Mathieson, Sean, additional, McCaul, Melisa Carrasco, additional, Meehan, Christopher, additional, Meledin, Irina, additional, Menna, Elisa, additional, Menzato, Federica, additional, Mintoft, Alison, additional, Mitra, Subhabrata, additional, Nakimuli, Annettee, additional, Nanyunya, Carol, additional, Norris, Georgina, additional, Northington, Frances J., additional, Numis, Adam, additional, O’Reilly, Jiaqi J., additional, Ortiz, Sandra, additional, Padiyar, Swetha, additional, Paquette, Natacha, additional, Parmeggiani, Lucio, additional, Patrizi, Silvia, additional, Pavlidis, Elena, additional, Pellegrin, Serena, additional, Penn, Anna A., additional, Petitpas, Laurence, additional, Pinchefsky, Elana, additional, Ponta, Alessandra, additional, Puthuraya, Jacopo Proietti Subhash, additional, Rais, Rana, additional, Robertson, Nicola J., additional, Rodrigues, Daniela, additional, Salandin, Michela, additional, Salzbank, Jacquelyn, additional, Sánchez, Lilia, additional, Schalij, Nienke, additional, Serrano-Tabares, Carolina, additional, Shany, Eilon, additional, Staffler, Alex, additional, Steggerda, Sylke, additional, Tachtsidis, Ilias, additional, Tann, Cally, additional, Tataranno, Maria Luisa, additional, Trabatti, Chiara, additional, Tremblay, Julie, additional, Tromp, Selma, additional, Tucker, Katie, additional, Turnbill, Victoria, additional, Vacher, Claire-Marie, additional, van Bel, Frank, additional, van der Aa, Niek E., additional, Van Meurs, Krisa, additional, Van Steenis, Andrea, additional, van Wyk, Linda, additional, Vannasing, Phetsamone, additional, Variane, Gabriel, additional, Verma, Vinita, additional, Voldal, Emily, additional, Wagenaar, Nienke, additional, Wu, Yvonne, additional, and Wustoff, Courtney, additional

Published
2023
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46. Proceedings of the 14th International Newborn Brain Conference: Neuro-imaging studies

Author

Herrera, Sofia, primary, Herrera, Sofia, additional, Cabacungan, Erwin, additional, Cohen, Susan, additional, Thyagarajan, Balamurugan, additional, Jefferies, Kimberley, additional, Avanaki, Kamran, additional, Manwar, Rayyan, additional, McGuire, Laura, additional, Islam, Tarikul, additional, Shoo, Anthony, additional, Charbel, Fady T, additional, Pillers, De-Ann M, additional, Verschuur, Anouk, additional, van Steenis, Andrea, additional, Boswinkel, Vivian, additional, Nijholt, Ingrid, additional, Boomsma, Martijn, additional, Steggerda, Sylke, additional, Meijler, Gerda, additional, Leijser, Lara, additional, Park, Seul Gi, additional, Yang, Hyo Ju, additional, Lim, Soo Yeon, additional, Kim, Seh Hyun, additional, Shin, Seoung Han, additional, Kim, Ee-Kyung, additional, Kim, Han-Suk, additional, Shiraki, Anna, additional, Kidokoro, Hiroyuki, additional, Watanabe, Hama, additional, Taga, Gentaro, additional, Narita, Hajime, additional, Mitsumatsu, Takamasa, additional, Kumai, Sumire, additional, Suzui, Ryosuke, additional, Sawamura, Fumi, additional, Ito, Yuji, additional, Yamamoto, Hiroyuki, additional, Nakata, Tomohiko, additional, Sato, Yoshiaki, additional, Hayakawa, Masahiro, additional, Natsume, Jun, additional, Buchmayer, Julia, additional, Kasprian, Gregor, additional, Giordano, Vito, additional, Jernej, Raphaela, additional, Klebermass-Schrehof, Katrin, additional, Berger, Angelika, additional, Goeral, Katharia, additional, Garvey, Aisling, additional, El-Shibiny, Hoda, additional, Yang, Edward, additional, Inder, Terrie, additional, El-Dib, Mohamed, additional, Grant, Ellen, additional, Manning, Simon, additional, Volpe, Joseph, additional, Roychaudhuri, Sriya, additional, Pineda, Roberta, additional, Sharon, Danielle, additional, Singh, Elizabeth, additional, Steele, Tina, additional, Sheldon, Yvonne, additional, Cuddyer, Deborah, additional, Erdei, Carmina, additional, Szakmar, Eniko, additional, Andorka, Csilla, additional, Barta, Hajnalka, additional, Sesztak, Timea, additional, Varga, Edit, additional, Szabo, Miklos, additional, Jermendy, Agnes, additional, Panzarini, Ilaria, additional, King, Regan, additional, Verschuur, Anouk S, additional, Hendson, Leonora, additional, Carlson, Helen, additional, Scotland, Jeanne, additional, Zein, Hussein, additional, Mohammed, Khorshid, additional, Bach, Ashley, additional, Lambing, Hannah, additional, Rogers, Elizabeth E., additional, Xu, Duan, additional, James, Barkovich A., additional, Ferriero, Donna M., additional, Glass, Hannah C., additional, Gano, Dawn, additional, Igreja, Liliana, additional, Ferreira, Adriana, additional, Gomes, Rita, additional, Sousa, Bebiana, additional, Novo, Ana, additional, Alves, José Eduardo, additional, Proença, Elisa, additional, and Carvalho, Carmen, additional

Published
2023
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47. Neuroimaging in infants with congenital cytomegalovirus infection and its correlation with outcome: emphasis on white matter abnormalities.

Author

Alarcón, Ana, de Vries, Linda S., Parodi, Alessandro, Arnáez, Juan, Cabañas, Fernando, Steggerda, Sylke J., Rebollo, Mónica, Ramenghi, Luca, Dorronsoro, Izaskun, López-Azorín, Manuela, Schneider, Juliane, Noguera-Julian, Antoni, Ríos-Barnés, María, Recio, Manuel, Bickle-Graz, Myriam, Martínez-Biarge, Miriam, Fortuny, Clàudia, García-Alix, Alfredo, and Truttmann, Anita C.

Published
2024
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48. Efficacy of Levetiracetam as Add-On Therapy in the Treatment of Seizures in Neonates.

Author

Rondagh, Mathies, De Vries, Linda S., Peeters-Scholte, Cacha M.P.C.D., Tromp, Selma C., and Steggerda, Sylke. J.

Subjects
CENTRAL nervous system infections, NEWBORN infants, NEONATAL intensive care units, SEIZURES (Medicine), LEVETIRACETAM
Abstract

Introduction: There is no consensus regarding the efficacy of add-on therapy with levetiracetam (LEV) in the treatment of seizures in neonates. The aim of this study was to evaluate the efficacy of add-on therapy with LEV for achieving >80% seizure reduction after phenobarbital (PB) treatment. Methods: Retrospective cohort study of near term neonates admitted to the neonatal intensive care unit with EEG-confirmed seizures despite treatment with PB as first-line therapy and using LEV as 2nd-, 3rd- or 4th-line treatment. Antiseizure medication was administered according to national guidelines. All neonates were monitored with 2-channel amplitude-integrated electroencephalography. The total seizure burden in minutes, 2 h before and 4 h after administration of LEV, was calculated using raw EEG. Primary outcome was the efficacy of LEV in achieving >80% seizure reduction. The efficacy of additional midazolam (MDZ) and lidocaine (LDC) was also calculated. Results: A total of 47 full-term neonates were included. The mean total loading dose of LEV was 40 mg/kg (36–44 mg/kg). Seizure etiology consisted of hypoxic-ischemic encephalopathy (n = 11), hemorrhagic or ischemic stroke (n = 16), central nervous system infection (n = 8), genetic (n = 8), metabolic disorders (n = 3), and unknown (n = 1). Following LEV administration, >80% seizure reduction was observed in 17% (8/47) of neonates, whereas it was 23% (6/26) after MDZ and 92% (23/25) after LDC administration. Discussion: Although the cumulative loading dose of LEV was low and the group of infants studied was heterogeneous, the efficacy of LEV as add-on therapy for the treatment of seizures in neonates was limited. The highest seizure reduction rate was seen after LDC administration. [ABSTRACT FROM AUTHOR]

Published
2024
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