Search

Your search keyword '"Steinbusch, Harry W."' showing total 572 results
Start Over Author "Steinbusch, Harry W."
572 results on '"Steinbusch, Harry W."'

15. The effect of chronic stress on behaviors, inflammation and lymphocyte subtypes in male and female rats

Author

Zhang, Cheng-Cai, Liu, B, Pawluski, Jodi, Steinbusch, Harry W. M., Kirthana Kunikullaya, U, Song, C, RS: MHeNs - R3 - Neuroscience, Basic Neuroscience 2, Psychiatrie & Neuropsychologie, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Guangdong Ocean University, Maastricht University [Maastricht], School for Mental Health and Neuroscience [Maastricht] (MHeNs), This work was supported by grants to CS from the Natural Science Fund of Guangdong Province (2021A1515011579), Shenzhen Science and Technology Plan (International Cooperation Research) Project (GJHZ20190823111414825), Zhanjiang Science and Technology Project (2021A05046), Guangdong Science and Technology Project (2016B020235001)., and Chard-Hutchinson, Xavier

Subjects
[SDV] Life Sciences [q-bio], Inflammation, Behavioral Neuroscience, Depression, [SDV]Life Sciences [q-bio], Sex differences, Chronic stress, Lymphocytes
Abstract

International audience; Excessively released proinflammatory mediators from activated macrophages and lymphocytes may contribute to the etiology of depression. However, the relationship between lymphocytes and depression is not fully understood. Although women have higher depression risk than men, sex/gender differences in psychoneuroimmunological mechanisms are still unclear. To explore these two questions, chronic unpredictable mild stress (CUMS) was used to evaluate the changes in behaviors, inflammation and lymphocyte subtypes in adult male and female Wistar rats. Results show that CUMS increased anhedonia and anxiety-like behaviors, along with increased serum corticosterone, hippocampal pro-inflammatory factors, CD11b, IFN-γ, IL-6 and IL-17, but decreased CD4, CD25, CD4/CD8 ratio, GFAP, 5-hydroxytryptamine (5-HT) and NE concentrations, regardless of sex. There was no positive correlation between sucrose preference and blood CD4/CD8 ratio, but a positive correlation between sucrose preference and spleen CD25, sucrose preference and neurotransmitters (NE and 5-HT), spleen CD25 and serum TGF-β1/IL-6 ratio were found, regardless of sex. Females presented higher basal locomotion, blood CD4, CD4/CD8 ratio, serum corticosteroid and IL-6 concentrations, but lower hippocampal norepinephrine (NE) than males. Although CUMS didn’t induce significant sex differences, females presented more changes in CD4 and CD8 lymphocytes than male rats. CUMS caused abnormalities in corticosteroid, lymphocytes, cytokines and neurotransmitters, which might be the precursors for inducing depression-like behaviors in both sexes.

Published
2023
Full Text
View/download PDF

21. Incidence, predictors, and impact of acute post-operative pain after cranial neurosurgery: A prospective cohort study.

Author

Sriganesh, Kamath, Kramer, Boris W., Wadhwa, Archisha, Akash, V. S., Bharadwaj, Suparna, Rao, G. S. Umamaheswara, Steinbusch, Harry W. M., Konar, Subhas K., Gopalakrishna, Kadarapura Nanjundaiah, and Sathyaprabha, T. N.

Subjects
POSTOPERATIVE pain, NEUROSURGERY, SLEEP quality, PATIENT satisfaction, LONGITUDINAL method
Abstract

Objectives: Pain is common after craniotomy. Its incidence and predictors in developing nations are not adequately studied. We aimed to assess the incidence, predictors, and impact of acute post-operative pain after intracranial neurosurgeries. Materials and Methods: This prospective observational study was conducted in adult patients undergoing intracranial neurosurgeries. After patient consent, ethics committee approval, and study registration, we assessed the incidence of post-operative pain using numerical rating scale (NRS) score. Predictors and impact of pain on patient outcomes were also evaluated. Results: A total of 497 patients were recruited during 10-month study period. Significant (4-10 NRS score) post-operative pain at any time-point during the first 3 days after intracranial neurosurgery was reported by 65.5% (307/469) of patients. Incidence of significant pain during the 1st post-operative h, on the 1st, 2nd, and 3rd post-operative days was 20% (78/391), 50% (209/418), 38% (152/401), and 24% (86/360), respectively. Higher pre-operative NRS score and pain during the 1st h post-operatively, predicted the occurrence of pain during the first 3 days after surgery, P = 0.003 and P < 0.001, respectively. Pain was significantly associated with poor sleep quality on the first 2 post-operative nights (P < 0.001). Patient satisfaction score was higher in patients with post-operative pain, P = 0.002. Conclusion: Every two in three patients undergoing elective intracranial neurosurgery report significant pain at some point during the first 3 postoperative days. Pre-operative pain and pain during 1st post-operative h predict the occurrence of significant post-operative pain. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

24. Systemic G-CSF attenuates cerebral inflammation and hypomyelination but does not reduce seizure burden in preterm sheep exposed to global hypoxia–ischemia

Author

Jellema, Reint K., Lima Passos, Valéria, Ophelders, Daan R.M.G., Wolfs, Tim G.A.M., Zwanenburg, Alex, De Munter, Stephanie, Nikiforou, Maria, Collins, Jennifer J.P., Kuypers, Elke, Bos, Gerard M.J., Steinbusch, Harry W., Vanderlocht, Joris, Andriessen, Peter, Germeraad, Wilfred T.V., and Kramer, Boris W.

Published
2013
Full Text
View/download PDF

48. Anatomical and neurochemical organization of the serotonergic system in the mammalian brain and in particular the involvement of the dorsal raphe nucleus in relation to neurological diseases

Author

Steinbusch, Harry W M, Dolatkhah, Mohammad Amin, Hopkins, David A, Di Giovanni, Giuseppe, De Deurwaerdere, Philippe, Academic Affairs, RS: MHeNs - R3 - Neuroscience, and Psychiatrie & Neuropsychologie

Subjects
Dorsal Raphe Nucleus, Serotonin, Parkinson's disease, Central nervous system, Biology, Serotonergic, RAT-BRAIN, 03 medical and health sciences, TRANSPORT FOLLOWING INJECTION, 0302 clinical medicine, Dorsal raphe nucleus, Alzheimer Disease, medicine, Animals, Humans, Autonomic nervous system, NITRIC-OXIDE SYNTHASE, HISTAMINE-LIKE IMMUNOREACTIVITY, Mammals, Neurotransmitter Agents, Depression, Neurodegeneration, CENTRAL-NERVOUS-SYSTEM, Neurodegenerative diseases, NECROSIS-FACTOR-ALPHA, RECEPTOR SUBTYPES, Frontotemporal lobar degeneration, MAJOR DEPRESSION, Alzheimer's disease, medicine.disease, SUBSTANCE-P, Neuroanatomy, medicine.anatomical_structure, CONTAINING NEURONS, Forebrain, Neuroscience, Brainstem, 030217 neurology & neurosurgery, Brain Stem
Abstract

The brainstem is a neglected brain area in neurodegenerative diseases, including Alzheimer's and Parkinson's disease, frontotemporal lobar degeneration and autonomic dysfunction. In Depression, several observations have been made in relation to changes in one particular the Dorsal Raphe Nucleus (DRN) which also points toward as key area in various age-related and neurodevelopmental diseases. The DRN is further thought to be related to stress regulated processes and cognitive events. It is involved in neurodegeneration, e.g., amyloid plaques, neurofibrillary tangles, and impaired synaptic transmission in Alzheimer's disease as shown in our autopsy findings. The DRN is a phylogenetically old brain area, with projections that reach out to a large number of regions and nuclei of the central nervous system, particularly in the forebrain. These ascending projections contain multiple neurotransmitters. One of the main reasons for the past and current interest in the DRN is its involvement in depression, and its main transmitter serotonin. The DRN also points toward the increased importance and focus of the brainstem as key area in various age-related and neurodevelopmental diseases. This review describes the morphology, ascending projections and the complex neurotransmitter nature of the DRN, stressing its role as a key research target into the neural bases of depression.

Published
2021

49. Additional file 1 of Region-specific amyloid-β accumulation in the olfactory system influences olfactory sensory neuronal dysfunction in 5xFAD mice

Author

Gowoon Son, Seung-Jun Yoo, Shinwoo Kang, Rasheed, Ameer, Jung, Da Hae, Hyunjun Park, Bongki Cho, Steinbusch, Harry W. M., Keun-A Chang, Yoo-Hun Suh, and Moon, Cheil

Abstract

Additional file 1: Figure S1. Verification of early-stage AD phenotype in 5xFAD transgenic mice. (a) Illustration of the time course for Y-maze and Morris water maze test. (b) Basic mobility tests using Y-maze showed the total number of arm entries (WT, n = 23; 5xFAD, n = 16). (c–d) Spontaneous alternation test using the Y-maze and Morris water maze test was performed to evaluate working memory (two-month: WT, n = 23; 5xFAD, n = 16, four-month: WT, n = 6; 5xFAD, n = 6, six-month: WT, n = 10; 5xFAD, n = 10). (c) A spontaneous alternation test using Y-maze was performed and the number of entries to another arm was measured (top). Scheme illustration (bottom). (d) The Morris water maze task was performed and the ratio of escape latency (WT/5xFAD) was measured (top). Scheme illustration (bottom). (e) Illustration of experimental timepoints identified in this research based on the result interpretation. One-way ANOVA was performed for statistical analysis. All data presented as mean ± SEMs. Statistical significances are noted [ns, non-significant; ***P

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results