1. Development, Preclinical Validation, and Clinical Translation of a Cardiac Magnetic Resonance - Electrophysiology System With Active Catheter Tracking for Ablation of Cardiac Arrhythmia.
- Author
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Chubb H, Harrison JL, Weiss S, Krueger S, Koken P, Bloch LØ, Kim WY, Stenzel GS, Wedan SR, Weisz JL, Gill J, Schaeffter T, O'Neill MD, and Razavi RS
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Cicatrix pathology, Electrophysiologic Techniques, Cardiac methods, Feasibility Studies, Female, Humans, Magnetic Resonance Imaging, Cine methods, Magnetic Resonance Imaging, Interventional methods, Male, Middle Aged, Observer Variation, Surgery, Computer-Assisted methods, Sus scrofa, Swine, Treatment Outcome, Young Adult, Atrial Flutter pathology, Atrial Flutter surgery, Catheter Ablation methods, Magnetic Resonance Angiography methods
- Abstract
Objectives: This study sought to develop an actively tracked cardiac magnetic resonance-guided electrophysiology (CMR-EP) system and perform first-in-human clinical ablation procedures., Background: CMR-EP offers high-resolution anatomy, arrhythmia substrate, and ablation lesion visualization in the absence of ionizing radiation. Implementation of active tracking, where catheter position is continuously transmitted in a manner analogous to electroanatomic mapping (EAM), is crucial for CMR-EP to take the step from theoretical technology to practical clinical tool., Methods: The setup integrated a clinical 1.5-T scanner, an EP recording and ablation system, and a real-time image guidance platform with components undergoing ex vivo validation. The full system was assessed using a preclinical study (5 pigs), including mapping and ablation with histological validation. For the clinical study, 10 human subjects with typical atrial flutter (age 62 ± 15 years) underwent MR-guided cavotricuspid isthmus (CTI) ablation., Results: The components of the CMR-EP system were safe (magnetically induced torque, radiofrequency heating) and effective in the CMR environment (location precision). Targeted radiofrequency ablation was performed in all animals and 9 (90%) humans. Seven patients had CTI ablation completed using CMR guidance alone; 2 patients required completion under fluoroscopy, with 2 late flutter recurrences. Acute and chronic CMR imaging demonstrated efficacious lesion formation, verified with histology in animals. Anatomic shape of the CTI was an independent predictor of procedural success., Conclusions: CMR-EP using active catheter tracking is safe and feasible. The CMR-EP setup provides an effective workflow and has the potential to change the way in which ablation procedures may be performed., (Copyright © 2017 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
- Published
- 2017
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