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Your search keyword '"Stephan-Gueldner, Markus"' showing total 9 results
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9 results on '"Stephan-Gueldner, Markus"'

2. Contributors

Author

Barrow, Paul, primary, Bayne, Kathryn, additional, Bluemel, Joerg, additional, Brennan, Frank, additional, Bolton, Iris D., additional, Bowman, Christopher J., additional, Buck, Wayne R., additional, Burns-Naas, Leigh Ann, additional, Burr, David B., additional, Cann, Jennifer A., additional, Cauvin, Annick J., additional, Cavagnaro, Joy A., additional, Certa, Ulrich, additional, Chapman, Kathryn, additional, Chellman, Gary J., additional, Coogan, Timothy P., additional, Couch, Jessica, additional, de Haan, Lolke, additional, Decelle, Thierry, additional, Delaunois, Annie, additional, Faggioni, Raffaella, additional, Ferguson, Betsy, additional, Finch, John, additional, Fisher, Virginia, additional, Frings, Werner, additional, Gelzleichter, Thomas, additional, Gschwind, Andreas, additional, Hall, Robert, additional, Halpern, Wendy G., additional, Heckel, Tobias, additional, Henson, Kristin L., additional, Henwood, Susan, additional, Heyen, Jonathan R., additional, Iverson, William Oliver, additional, Kallman, Mary Jeanne, additional, Kaspareit, Joachim, additional, Koban, Tina, additional, Korte, Sven, additional, Lainée, Pierre, additional, Leach, Michael W., additional, LeSauteur, Lynne, additional, Lewis, Anne D., additional, Lima, Beatriz Silva, additional, Ma, Yanfei L., additional, Mansfield, Keith G., additional, Luetjens, C. Marc, additional, Martin, Pauline L., additional, Mätz-Rensing, Kerstin, additional, Mikkelsen, Lars Fris, additional, Mounho-Zamora, Barbara, additional, Müller, Wolfgang, additional, Murphy, Dennis J., additional, Niehoff, Marc, additional, Niggemann, Birgit, additional, Palmer, Helen, additional, Patrick, Daniel J., additional, Peters, Christopher, additional, Piché, Marie-Soleil, additional, Prescott, Mark, additional, Prongay, Kamm, additional, Rebelatto, Marlon C., additional, Reymond, Alexandre, additional, Richman, Laura, additional, Roos, Christian, additional, Roskos, Lorin K., additional, Saravanan, Chandrassegar, additional, Sasseville, Vito G., additional, Schenck, Emanuel, additional, Schmitt, Georg, additional, Shenton, Jacintha M., additional, Singh, Anjali, additional, Skinner, Matthew, additional, Smith, David Glenn, additional, Stephan-Gueldner, Markus, additional, Todd, Marque, additional, Tseng, Chih-Ming L., additional, Vahle, John L., additional, Valentin, Jean-Pierre, additional, Vargas, Hugo M., additional, Wakshull, Eric, additional, Walter, Lutz, additional, Weinbauer, Gerhard F., additional, Wistuba, Joachim, additional, Yang, Harry, additional, and Zinner, Dietmar, additional

Published
2015
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5. An Approach to Minimise Dog Use in Regulatory Toxicology: Production of a Best Practice Guide to Study Design

Author

Phillips, Barry, primary, Smith, David, additional, Combes, Robert, additional, Descotes, Gerard, additional, Jacobsen, Soren Dyring, additional, Hack, Ruediger, additional, Kemkowski, Joerg, additional, Krauser, Klaus, additional, Pfister, Rudolf, additional, Rabemampianina, Yvon, additional, Sparrow, Sue, additional, Stephan-Gueldner, Markus, additional, and von Landenberg, Friedrich, additional

Published
2004
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6. Preclinical Safety Evaluation Using Nonrodent Species: An Industry/Welfare Project to Minimize Dog Use

Author

Smith, David, primary, Broadhead, Caren, additional, Descotes, Gerard, additional, Fosse, Richard, additional, Hack, Ruediger, additional, Krauser, Kiaus, additional, ister, Rudolf Pf, additional, Phillips, Barry, additional, Rabemampianina, Yvon, additional, Sanders, James, additional, Sparrow, Sue, additional, Stephan-Gueldner, Markus, additional, and Dyring Jacobsen, Soren, additional

Published
2002
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9. Multiple comparisons model-based clustering and ternary pattern tree numerical display of gene response to treatment: procedure and application to the preclinical evaluation of chemopreventive agents.

Author

Sutter TR, He XR, Dimitrov P, Xu L, Narasimhan G, George EO, Sutter CH, Grubbs C, Savory R, Stephan-Gueldner M, Kreder D, Taylor MJ, Lubet R, Patterson TA, and Kensler TW

Subjects
Animals, Down-Regulation, Female, Humans, Models, Chemical, Models, Statistical, RNA metabolism, Rats, Rats, Sprague-Dawley, Software, Statistics as Topic methods, Up-Regulation, Anticarcinogenic Agents pharmacology, Neoplasms drug therapy, Neoplasms genetics, Oligonucleotide Array Sequence Analysis methods
Abstract

Microarray technology has greatly aided the identification of genes that are expressed differentially. Statistical analysis of such data by multiple comparisons procedures has been slow to develop, in part, because methods to cluster the results of such comparisons in biologically meaningful ways have not been available. We isolated and analyzed, by Northern blot and GeneChip, replicate liver RNA samples (n = 4/group) from rats fed with control diet or diet containing one of three chemopreventive compounds, selected because their pharmacological activities, including RNA expression response, are relatively well understood. We report on a classification tree, based on the results of nonparametric multiple comparisons, which results in the bipolar hierarchical clustering of genes in relation to their response to treatment. In addition to identifying treatment-responsive genes, application of this procedure to our test study identified the known pharmacological relationships among the treatment groups without supervision. Also, small treatment-specific subsets of genes were identified that may be indicative of additional pharmacophores present in the test compounds.

Published
2002

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