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244 results on '"Steplewski, Zenon"'

24. Elevated expression of H type GDP-L-fucose: beta-D-galactoside alpha-2-L-fucosyltransferase is associated with human colon adenocarcinoma progression

Author

Sun, Jing, Thurin, Jan, Cooper, Harry S., Wang, Ping, Mackiewicz, Miroslav, Steplewski, Zenon, and Balszczyk-Thurin, Magdalena

Subjects
Colorectal cancer -- Genetic aspects, Adenocarcinoma -- Genetic aspects, Tumors -- Genetic aspects, Science and technology
Abstract

DNA synthesis and PCR on total RNA extracted from human colon tissues revealed 40- and 340-fold increases in mRNA transcript levels for the human H gene-encoded beta-D-galactoside alpha-2-L-fucosyltransferase in adenocarcinomas and tumor cell lines compared to normal colon mucosa. DNA sequence analysis of the plasmid insert in the protein coding region of the cDNAs from normal colon, adenoma and colon adenocarcinoma revealed 100% homology. These results suggest that beta-D-galactoside alpha-2-L-fucosyltransferase expression is correlated with the development of colon adenocarcinoma.

Published
1995

30. The Cell and its Components

Author

Studzinski, G. P., Love, R., Zbarsky, I. B., Khrushchov, N. G., Yermolaeva, L. P., Vinnikov, J. A., Titova, L. K., Osipova, I. V., Bronshtein, A. A., Vorbrodt, Andrzej, Steplewski, Zenon, Wolman, M., Strauss, W., Ericsson, Jan L. E., Trump, Benjamin F., Rostgaard, Jorgen, Barrnett, Russell J., Voss, Herbert, Wittekind, D., Rentsch, G., Takada, Hideo, Schiebler, T. H., editor, Pearse, A. G. E., editor, and Wolff, H. H., editor

Published
1964
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31. Third International Congress of Histochemistry and Cytochemistry

Author

Abe, Muneaki, Akamatsu, Masasuke, Matsumoto, Takaharu, Ohuchi, Nobuo, Masuya, Tomichi, Abe, T., Nakashio, K., Kazama, M., Matsuda, M., Adams, C. W. M., Virág, S., Morgan, R. S., Orton, C. C., Adams, Jean R., Wilcox, Theodore A., Akert, Konrad, Alberti, Rachele, Allen, Robert C., Moore, Dorothy J., Tyndall, Richard L., Anderson, Paul J., Song, Sun K., Angelakos, E. T., King, M. P., Appleton, Timothy C., Arstila, Antti U., Trump, Benjamin F., Lauria, A., Bahr, Gunter F., Wied, George L., Bartels, Peter H., Bajusz, E., Balogh, Kåroly, Barer, R., Barka, Tibor, Barnard, Eric A., Komender, Janusz, Wieckowski, Jan, Barrnett, R. J., Barron, K. D., Koeppen, A. H., Bernsohn, J., Bélanger, Leonard F., Beltrami, Carlo Alberto, Björklund, A., Ehinger, B., Falck, B., Boadle, Margaret C., Bloom, Floyd E., Bona, C., Bradshaw, M., Monus, L., Stroman, S., Budd, G. C., Salpeter, M. M., Bukhonova, A. I., Burnasheva, S. A., Jurzina, G. A., Burt, Alvin M., Chang, Jeffrey P., Schatzki, Peter F., Saito, Takuma, Chavin, Walter, Chyle, M., Korych, B., Lojda, Zdenek, Patocka, F., Cohn, Z. A., Conning, D. M., Coutinho, Hélio B., Rocha, Jácia T., Jales, Benjamin F., Cunningham, Lew, Heitsch, Richard, Daneholt, B., Edström, J.-E., Danilova, L. V., Rokhlenko, K. D., Dauwalder, M., Whaley, W. G., Kephart, J. E., Deitch, Arline D., Sawicki, Stanley G., Godman, Gabriel C., Della Corte, Francesco, Desmet, V. J., Bullens, A.-M., De Groote, J., Heirwegh, K. P. M., Diculescu, I., Onicescu, Doina, Szegly, G., Doane, Winifred W., Donskikh, N. V., Novikov, V. D., Subbotin, M. Ya., Tsirelnikov, N. I., Doolin, Paul F., Birge, Wesley J., Droz, Bernard, Bergeron, M., Drukker, J., Duarte-Escalante, Ovidio, Dubowitz, Victor, Dupraw, E. J., Eckner, Friedrich A. O., Blackstone, Eugene H., Moulder, Peter V., Ehrlich, M. P., Ellis, Stanley, McDonald, J. Ken, Callahan, P. X., Enesco, Hildegard E., Engel, W. King, Epifanova, O. I., Lomakina, L. Ya., Terskikh, V. V., Ericsson, Jan L. E., Jakobsson, Sten, Eristawi, K. D., Sharashidze, L. K., Sturua, N. S., Fabris, Guidalberto, Mariuzzi, Gianmario, Nenci, Italo, Fahimi, H. Dariush, Karnovsky, Morris J., Fand, Sally B., Farquhar, Marilyn G., Felgenhauer, K., Glenner, G. G., Stammler, A., Filkuka, J., Svejda, J., Áubrechtova, V., Filotto, U., Fischbein, J. W., Rutenburg, Alexander M., Fisher, Donald B., Forni, Alessandra, Nencioni, Torquato, Ballare’, Gianfranco, Fotin, Ludmila, Popescu, Maria, Frankfurt, O. S., Friend, Daniel S., Fuchs, B. B., Arutyunov, V. D., Shnaper, A. L., Gabunia, U. A., Shiukashvili, N. N., Gahan, P. B., Anker, P., Stroun, M., McLean, Jean, Galjaard, H., Bootsma, D., Ganina, K. P., Garcia, Alfredo Mariano, Garrett, J. R., Gepts, W., Gregoire, F., Ooms, H., Gerzeli, Giuseppe, Giacobini, Ezio, Hovmark, Stefan, Gilkerson, Seth W., Glick, David, Godlewski, H. G., Huszczuk, A., Penar, Barbara, Goldfischer, Sidney, Sternlieb, Irmin, Goldstone, A., Szabo, E., Koenig, Harold, Gornak, K. A., Goslar, H. G., Grigoriadis, P., Jaeger, K. H., Gössner, W., Benoit, H., Gracheva, Nina D., Grillo, T. Adesanya Ige, Gropp, A., Gross, U. M., Gueft, Boris, Guha, S., Fouquet, J. P., Håkanson, R., Owman, Ch., Sporrong, B., Hale, A. J., Marshall, D. J., Switsur, V. R., Hanker, Jacob S., Zenker, Nicolas, Morizono, Yoshihisa, Deb, Chandicharan, Seligman, Arnold M., Hardonk, M. J., Elema, J. D., Koudstaal, Joh., Hoedemaeker, Ph. J., Hayashi, Masando, Heller, A., Hernández, F., Martinez De Morentin, J., Herrmann, Hans-Jürgen, Hershey, Falls B., Hess, H. H., Pope, A., Bass, N. H., Hewitt, J. M., Guigon, M., Bolubasz, J., Himes, M. H., Burdick, C., Hirai, Kei-Ichi, Takamatsu, Hideo, Hirose, Shunta, Hirsch, Hilde E., Hodges, Donald R., Costoff, Allen, McShan, W. H., Holtzman, Eric, Holubar, K., Tappeiner, J., Wolff, K., Hopsu-Havu, Väinö K., Hosannah, Yvonne, Blackwood, Carlton E., Mandl, Ines, Hoskins, Godfrey C., Hugon, J. S., Borgers, M., Hurwitz, Lawrence S., Rubinstein, Lucien J., Ibrahim, M. Z. M., Imura, Shin-Ichi, Takeda, Masanori, Jacobsen, N. O., Jørgensen, P. Leth, Jarrett, A., Joandrea-Casian, Claudia, Prundeanu, Cornelia, Johnson, Anne B., Johnson, Waine C., Alkek, David S., Jongkind, J. F., Swaab, D. F., Jos, J., Junqueira, L. C., Toledo, A. M. Souza, Kaiser, Hans E., Kakari, Sophia, Kalina, Moshe, Bubis, Jose. J., Kamentsky, L. A., Kasten, Frederick H., Kiefer, Gunter G., Sandritter, W., Killander, D., Rigler, R., Kishino, Yasuo, Kobayashi, H., Urano, A., Yokoyama, K., Koelle, George B., Hughes, Charles, Korhonen, L. Kalevi, Kramer, M. F., Poort, C., Kreutzberg, Georg W., Künzel, Erich, Tanyolac, Attila, Labella, Frank S., Langley, O. K., Lanza, Giovanni B., Lappano-Colletta, Eleanor Rita, Leblond, C. P., Merzel, J., Cheng, Hazel, Nadler, N. J., Herscovics, Annette A., Lederer, B., Mittermayer, C., Lee, Sin Hang, Torack, Richard M., Lehrer, Gerard M., Bornstein, Murray B., Katzman, Robert, Leites, F. L., Tendetnik, Ju. J., Ruchadse, E. S., Rjadneva, O. E., Leppi, T. John, Kinnison, Patricia A., Gaffney, Susan P., Lev, Robert, Gerard, Andre, De Graef, Jacques, Jerzy Glass, George B., Lhotka, J. F., Jr., Anderson, J. W., Liber, Amour F., Lillie, R. D., Pizzolato, Philip, Lindner, J., Grasedyck, K., Johannes, G., Freytag, G., Lipchina, L. P., Aksyutina, M. S., Yablonovskaya, L. Ya., Lipetz, Jacques, Liu, J. C., Roizin, L., Lodin, Z., Kage, M., Hartman, J., Srajer, J., Fric, Premysl, Long, Margaret E., Sommers, Sheldon C., McGarry, E. E., Nayak, R., Birch, E., Beck, J. C., McMillan, Paul J., Adeoye, Christopher ’Seinde, Macovschi, O., Maeda, Ryuei, Ihara, Nobuo, Kanazawa, Kokichi, Maeir, David M., Wagner, Lenore, Maggi, Viviane, Franks, L. M., Livingston, D. C., Coombs, M. M., Wilson, Patricia D., Carbonell, A. W., Malyuk, V. I., Romanini, Manfredi, Gabriella, Maria, Fraschini, Annunzia, Porcelli, Franca, Manocha, Sohan L., Shantha, Totada R., Bourne, Geoffrey H., Marques, Dante, Bastos, A. L., Baptista, A. M., Vigario, J. D., Nunes, J. M., Terrinha, A. M., Silva, J. A. F., Masurovsky, E. B., Benitez, H. H., Kim, S-U., Murray, M. R., Matschinsky, F. M., Rutherford, C. L., Guerra, L., Matturri, L., Curri, S., Melnick, P. J., Mendelsohn, M. L., Conway, T. J., Perry, B., Prewitt, J. M. S., Mercado, Teresa I., Miksche, Jerome P., Misch, Donald W., Misch, Margaret S., Mitchell, J. P., Mizuhira, Vinci, Uchida, Kazuko, Amakawa, Takanori, Shindo, Hideo, Totsu, Junichi, Suesada, Ikuo, Mizutani, Akira, Monis, Benito, Candiotti, Alberto, Mori, G., Ingrami, A., Morikawa, Shigeru, Yamamura, Masao, Harada, Takayuki, Hamashima, Yoshihiro, Mullaney, P. F., Dean, P. N., Van Dilla, M. A., Müller, Gerhard, Müller, Otfried, Nakane, Paul K., Neurath, Peter W., Curtis, Zay B., Selles, William, Vetter, Henri G., Norgren, P. E., Novikoff, Alex B., O’Brien, Regina, Ohringer, Philip, Spitaleri, Vincent, Olszewska, M. J., Gabara, B., Konopska, L., Parfanovich, M. I., Sokolov, N. N., Berezina, O. N., Fadeeva, L. L., Pauly, John E., Scheving, Lawrence E., Pearse, A. G. E., Pearson, Bjarne, Bennett, William, Esterly, John R., Standen, Alfred C., Pelc, S. R., Viola-Magni, M. P., Penttilä, Antti, Perez, Vernon J., Moore, Blake W., Peters, Theodore, Jr., Danzi, J. Thomas, Ashley, Charles A., Petrova, A. S., Probatova, N. A., Philippens, Karel, Pilgrim, C., Pollock, B. M., Presnov, M. A., Preston, Kendall, Jr., Preto Parvis, V., Cisotti, F., Prewitt, Judith M. S., Mayall, Brian H., Mendelsohn, Mortimer L., Pryse-Davis, John, Sandler, Merton, Quay, W. B., Raikhlin, N. T., Rasch, Ellen M., Riecken, E. O., Goebell, H., Bode, C., Rigatuso, Joseph L., Ringertz, N. R., Bolund, L., Ritter, Carl, Thorell, Bo, Rizzotti, M., Aureli, G., Balduini, C., Castellani, A. A., Rosenbaum, Robert M., Rosene, Gordon L., Rossi, Ferdinando, Rost, F. W. D., Roth, Daniel, Ruch, Fritz, Ruddle, Frank H., Lubs, Herbert A., Ledley, Robert S., Shows, Thomas B., Roderick, Thomas H., Kim, H., Brodie, E., Rosales, C. L., Sadauskas, P., Luksys, L., Dabkevcius, V., Sakharova, A. V., Sakharov, D. A., Samosudova, N. V., Ogieveckaja, M. M., Kalamkarova, M. B., Sandler, Maurice, Santti, R. S., Sasaki, Mitsuo, Takeuchi, Tadao, Satir, P., Schauer, Alfred, Scher, Stanley, Haley, Patricia L., Schiebler, T. H., Schiemer, Hans-Georg, Schlüns, Jürgen, Schuster, F. L., Hershenov, B., Scott, J. E., Scott, T. Gilbert, Seno, Satimaru, Yokomura, Ei-Ichi, Itoh, Nobutaka, Yamamoto, Michio, Shungskaya, V. E., Enenko, S. O., Lukyanova, L. D., Sarch, E. N., Shuter, Eli, Jungalwala, Firoze, Robins, Eli, Sierakowska, Halina, Silverman, L., Simard, A., Daoust, R., Smith, Edgar E., Smith, R. E., Fishman, William H., Henzl, Milan, Sobel, Harold J., Avrin, Erna, Sorokin, Helen P., Sorokin, Sergei, Squier, C. A., Waterhouse, J. P., Steinbach, Günter, Steplewski, Zenon, Stitnimankarn, Tinrat, Stoward, Peter J., Straus, W., Stumpf, Walter E., Roth, Lloyd J., Sylvén, B., Kanamura, Shinsuke, Templeton, McCormick, Tewari, H. B., Tyagi, H. R., Thalmann, R., Glismann, L., Thomas, E., Tice, Lois W., Tixier-Vidal, A., Törö, I., Bacsy, E., Vadasz, Gy., Rappay, Gy., Tsou, K. C., Chang, Mildred Y., Matsukawa, S., Goodwin, Cleon, Lynm, Dwo, Seamond, Bette, Van Der Ploeg, M., Van Duijn, P., Coulter, J. R., Pascoe, E., Van Fleet, D. S., VanHouten, Wiecher H., Vecher, A. S., Masko, A. A., Predkel, K. I., Reshetnikov, V. N., Tchaika, M. T., Velican, C., Velican, Doina, Vendrely, C., Lageron, A., Tournier, P., Vialli, Maffo, Prenna, Giovanni, Vilter, Voldemar, Vittek, Josef, Vogt, Arnold, Vollrath, L., Von Mayersbach, Heinz, Vorbrodt, Andrzej, Wächtler, Klaus, Wakabayashi, Katsumi, Tamaoki, Bun-Ichi, Wald, Niel, Ranshaw, Russell, Weller, Roy O., Welsch, Ulrich, Werner, Gottfried, Williams, Vick, Morriss, Fran, Willighagen, R. G. J., Wilson, Barry W., Wohlrab, Frank, Wolf, Paul L., Horwitz, Jerome P., Freisler, Josef V., Von Der Muehll, Elisabeth, Vazquez, Janice, Wolman, Moshe, Yamada, Masaoki, Iwata, Sunao, Yamaguchi, Hisao, Yataganas, X., Gahrton, G., Young, Ian T., Zaccheo, D., Grossi, C. E., Genta, V., Riva, A., Zacks, S. I., Sheff, M. F., Zamfirescu-Gheorghiu, M., Serban, M., Vladescu, C., Chirulescu, Z., Marcus, N., Zelenin, A. V., Kirianova, E. A., Stepanova, N. G., Zeuthen, Erik, Zimmermann, Horst, Zugibe, Frederick T., Abrahamson, Dean E., Anderson, Norman G., Caspersson, Törbjorn, Cornell, Richard, Dougherty, William, Jirasek, J. E., Jonsson, Gösta, Leske, Regina, Moyer, Frank H., Schneider, Walter C., Siegel, Howard I., Sternberger, Ludwig, Osserman, Elliott F., Weinstock, A., and Rosenbaum, Robert M.

Published
1968
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44. Zelle und Zellbestandteile

Author

Studzinski, G. P., primary, Love, R., additional, Zbarsky, I. B., additional, Khrushchov, N. G., additional, Yermolaeva, L. P., additional, Vinnikov, J. A., additional, Titova, L. K., additional, Osipova, I. V., additional, Bronshtein, A. A., additional, Vorbrodt, Andrzej, additional, Steplewski, Zenon, additional, Wolman, M., additional, Strauss, W., additional, Ericsson, Jan L. E., additional, Trump, Benjamin F., additional, Rostgaard, Jorgen, additional, Barrnett, Russell J., additional, Voss, Herbert, additional, Wittekind, D., additional, Rentsch, G., additional, and Takada, Hideo, additional

Published
1964
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45. Third International Congress of Histochemistry and Cytochemistry

Author

Muneaki, Abe, primary, Akamatsu, Masasuke, additional, Matsumoto, Takaharu, additional, Ohuchi, Nobuo, additional, Masuya, Tomichi, additional, Abe, T., additional, Nakashio, K., additional, Kazama, M., additional, Matsuda, M., additional, Adams, C. W. M., additional, Virág, S., additional, Morgan, R. S., additional, Orton, C. C., additional, Adams, Jean R., additional, Wilcox, Theodore A., additional, Akert, Konrad, additional, Alberti, Rachele, additional, Allen, Robert C., additional, Moore, Dorothy J., additional, Tyndall, Richard L., additional, Anderson, Paul J., additional, Song, Sun K., additional, Angelakos, E. T., additional, King, M. P., additional, Appleton, Timothy C., additional, Arstila, Antti U., additional, Trump, Benjamin F., additional, Aureli, G., additional, Lauria, A., additional, Rizzotti, M., additional, Bahr, G. F., additional, Wied, G. L., additional, Bartels, P., additional, Bajusz, E., additional, Barer, R., additional, Barka, Tibor, additional, Barnard, Eric A., additional, Komender, Janusz, additional, Wieckowski, Jan, additional, Barrnett, R. J., additional, Barron, K. D., additional, Koeppen, A. H., additional, Bernsohn, J., additional, Bélanger, Leonard F., additional, Beltrami, Carlo Alberto, additional, Björklund, A., additional, Ehinger, B., additional, Falck, B., additional, Boadle, Margaret C., additional, Bloom, Floyd E., additional, Bona, C., additional, Bradshaw, M., additional, Stroman, S., additional, Monus, L., additional, Budd, G. C., additional, Salpeter, M. M., additional, Bukhonova, A. I., additional, Burnasheva, S. A., additional, Jurzina, G. A., additional, Burt, Alvin M., additional, Chang, Jeffre Y. P., additional, Schatzki, Peter F., additional, Saito, Takuma, additional, Chavin, Walter, additional, Chyle, M., additional, Korych, B., additional, Lojda, Z., additional, Patocka, F., additional, Cohn, Z. A., additional, Conning, D. M., additional, Coutinho, Hélio B., additional, Rocha, Jácia T., additional, Jales, Benjamin F., additional, Cunningham, Lew, additional, Heitsch, Richard, additional, Daneholt, B., additional, Edström, J.-E., additional, Danilova, L. V., additional, Rokhlenko, K. D., additional, Dauwalder, M., additional, Whaley, W. G., additional, Kephart, J. E., additional, Deitch, Arline D., additional, Sawicki, Stanley G., additional, Godman, Gabriel C., additional, Francesco, Della Corte, additional, Desmet, V. J., additional, Bullens, A.-M., additional, De Groote, J., additional, Heirwegh, K. P. M., additional, Diculescu, I., additional, Onicescu, Doina, additional, Szegly, G., additional, Doane, Winifred W., additional, Donskikh, N. V., additional, Novikov, V. D., additional, Subbotin, M. Ya., additional, Tsirelnikov, N. I., additional, Doolin, Paul F., additional, Birge, Wesley J., additional, Bernard, Droz, additional, Droz, B., additional, Bergeron, M., additional, Drukker, J., additional, Duarte-Escalante, Ovidio, additional, Dubowitz, Victor, additional, Dupraw, E. J., additional, Eckner, Friedrich A. O., additional, Blackstone, Eugene H., additional, Moulder, Peter V., additional, Ehrlich, M. P., additional, Stanley, Ellis, additional, McDonald, J. Ken, additional, Callahan, P. X., additional, Epifanova, O. I., additional, Lomakina, L. Ya., additional, Terskikh, V. V., additional, Ericsson, Jan L. E., additional, Jakobsson, Sten, additional, Eristawi, K. D., additional, Sharashidze, L. K., additional, Sturua, N. S., additional, Fabris, G., additional, Mariuzzi, G. M., additional, Nenci, I., additional, Fahimi, Dariush H., additional, Karnovsky, Morris J., additional, Fand, Sally B., additional, Farquhar, Marilyn G., additional, Felgenhauer, K., additional, Glenner, G. G., additional, Stammler, A., additional, Filkuka, J., additional, Svejda, J., additional, Áubrechtova, V., additional, Filotto, U., additional, Fischbein, J. W., additional, Rutenburg, A. M., additional, Fisher, Donald B., additional, Alessandra, Forni, additional, Nencioni, Torquato, additional, Ballare, Gianfranco, additional, Ludmila, Fotin, additional, Popescu, Maria, additional, Frankfurt, O. S., additional, Friend, Daniel S., additional, Fuchs, B. B., additional, Arutyunov, V. D., additional, Shnaper, A. L., additional, Gabunia, U. A., additional, Shiukashvili, N. N., additional, Gahan, P. B., additional, Anker, P., additional, Stroun, M., additional, McLean, Jean, additional, Galjaard, H., additional, Bootsma, D., additional, Ganina, K. P., additional, Garcia, Alfredo Mariano, additional, Garrett, J. R., additional, Gepts, W., additional, Gregoire, F., additional, Ooms, H., additional, Giuseppe, Gerzeli, additional, Ezio, Giacobini, additional, Hovmark, Stefan, additional, Gilkerson, Seth W., additional, David, Glick, additional, Godlewski, H. G., additional, Huszczuk, A., additional, Penar, Barbara, additional, Goldfischer, Sidney, additional, Sternlieb, Irmin, additional, Goldstone, A., additional, Szabo, E., additional, Koenig, H., additional, Gornak, K. A., additional, Goslar, H. G., additional, Grigoriadis, P., additional, Jaeger, K. H., additional, Gössner, W., additional, Benoit, H., additional, Gracheva, Nina D., additional, Grillo, T. Adesanya Ige, additional, Gropp, A., additional, Gross, U. M., additional, Gueft, Boris, additional, Guha, S., additional, Fouquet, J. P., additional, Håkanson, R., additional, Owman, Ch., additional, Sporrong, B., additional, Hale, A. J., additional, Marshall, D. J., additional, Switsur, V. R., additional, Hanker, Jacob S., additional, Zenker, Nicolas, additional, Morizono, Yoshihisa, additional, Deb, Chandicharan, additional, Seligman, Arnold M., additional, Hardonk, M. J., additional, Elema, J. D., additional, Koudstaal, Joh, additional, Hoedemaeker, Ph. J., additional, Hayashi, Masando, additional, Heller, A., additional, Hernández, F., additional, De Morentin, J. Martinez, additional, Hans-Jürgen, Herrmann, additional, Hershey, Falls B., additional, Hess, H. H., additional, Pope, A., additional, Bass, N. H., additional, Hewitt, J. M., additional, Guigon, M., additional, Bolubasz, J., additional, Himes, M. H., additional, Burdick, C., additional, Hirai, Kei-Ichi, additional, Takamatsu, Hideo, additional, Shunta, Hirose, additional, Hirsch, Hilde E., additional, Hodges, Donald R., additional, Costoff, Allen, additional, McShan, W. H., additional, Holtzman, Eric, additional, Holubar, K., additional, Tappeiner, J., additional, Wolff, K., additional, Hopsu-Havu, Vainö K., additional, Hosannah, Yvonne, additional, Blackwood, Carlton E., additional, Mandl, Ines, additional, Hoskins, Godfrey C., additional, Hugon, J. S., additional, Borgers, M., additional, Hurwitz, Lawrence S., additional, Rubinstein, Lucien J., additional, Ibrahim, M. Z. M., additional, Imura, Shin-Ichi, additional, Takeda, Masanori, additional, Jacobsen, N. O., additional, Jørgensen, P. Leth, additional, Jarrett, A., additional, Claudia, Joandrea-Casian, additional, Prundeanu, Cornelia, additional, Johnson, Anne B., additional, Johnson, Waine C., additional, Alkek, David S., additional, Jongkind, J. F., additional, Swaab, D. F., additional, Jos, J., additional, Junqueira, L. C., additional, Toledo, A. M. Souza, additional, Kaiser, Hans E., additional, Kakari, Sophia, additional, Kalina, Moshe, additional, Bubis, Jose. J., additional, Kamentsky, L. A., additional, Kasten, Frederick H., additional, Kiefer, Gunter G., additional, Sandritter, W., additional, Killander, D., additional, Rigler, R., additional, Yasuo, Kishino, additional, Kobayashi, H., additional, Urano, A., additional, Yokoyama, K., additional, Koelle, George B., additional, Koenig, Harold, additional, Hughes, Charles, additional, Korhonen, Kalevi L., additional, Kramer, M. F., additional, Poort, C., additional, Kreutzberg, Georg W., additional, Künzel, Erich, additional, Tanyolac, Attila, additional, Labella, Frank S., additional, Langley, O. K., additional, Lanza, Giovanni B., additional, Lappano-Colletta, Eleanor Rita, additional, Leblond, C. P., additional, Merzel, J., additional, Cheng, Hazel, additional, Nadler, N. J., additional, Herscovics, Annette A., additional, Lederer, B., additional, Mittermayer, C., additional, Lee, Sin Hang, additional, Torack, Richard M., additional, Lehrer, Gerard M., additional, Bornstein, Murray B., additional, Katzman, Robert, additional, Leites, F. L., additional, Tendetnik, Ju. J., additional, Ruchadse, E. S., additional, Rjadneva, O. E., additional, Leppi, T. John, additional, Kinnison, Patricia A., additional, Gaffney, Susan P., additional, Lev, Robert, additional, Gerard, Andre, additional, de Graef, Jacques, additional, Glass, George B. Jerzy, additional, Lhotka, J. F., additional, Anderson, J. W., additional, Liber, Amour F., additional, Lillie, R. D., additional, Pizzolato, Philip, additional, Lindner, J., additional, Grasedyck, K., additional, Johannes, G., additional, Freytag, G., additional, Gries, G., additional, Lipchina, L. P., additional, Aksyutina, M. S., additional, Yablonovskaya, L. Ya., additional, Lipetz, Jacques, additional, Liu, J. C., additional, Roizin, L., additional, Lodin, Z., additional, Kage, M., additional, Hartman, J., additional, Srajer, J., additional, Lojda, Zdenek, additional, Fric, Premysl, additional, Long, Margaret E., additional, Sommers, Sheldon C., additional, Ken, McDonald J., additional, Ellis, Stanley, additional, McGarry, E. E., additional, Nayak, R., additional, Birch, E., additional, Beck, J. C., additional, McMillan, Paul J., additional, Adeoye, Christopher ’Seinde, additional, Macovschi, O., additional, Maeda, Ryuei, additional, Ihara, Nobuo, additional, Kanazawa, Kokichi, additional, Maeir, David M., additional, Wagner, Lenore, additional, Viviane, Maggi, additional, Franks, L. M., additional, Livingston, D. C., additional, Coombs, M. M., additional, Wilson, Patricia D., additional, Carbonell, A. W., additional, Malyuk, V. 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Published
1968
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48. Treatment of Gastrointestinal Cancer Using Monoclonal Antibodies

Author

Markoe, Arnold M., primary, Brady, Luther W., additional, Woo, David, additional, Amendola, Beatriz, additional, Karlsson, Ulf, additional, Fisher, Scot, additional, Micaily, Bizhan, additional, Rackover, Michael, additional, Bulova, Stephen, additional, Steplewski, Zenon, additional, and Koprowski, Hilary, additional

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50. Plant-derived EpCAM antigen induces protective anti-cancer response.

Author

Brodzik, Robert, Spitsin, Sergei, Golovkin, Max, Bandurska, Katarzyna, Portocarrero, Carla, Okulicz, Monika, Steplewski, Zenon, Koprowski, Hilary, Brodzik, Robert, Spitsin, Sergei, Golovkin, Max, Bandurska, Katarzyna, Portocarrero, Carla, Okulicz, Monika, Steplewski, Zenon, and Koprowski, Hilary

Abstract

Immunotherapy holds great promise for treatment of infectious and malignant diseases and might help to prevent the occurrence and recurrence of cancer. We produced a plant-derived tumor-associated colorectal cancer antigen EpCAM (pGA733) at high yields using two modern plant expression systems. The full antigenic domain of EpCAM was efficiently purified to confirm its antigenic and immunogenic properties as compared to those of the antigen expressed in the baculovirus system (bGA733). Recombinant plant-derived antigen induced a humoral immune response in BALB/c mice. Sera from those mice efficiently inhibited the growth of SW948 colorectal carcinoma cells xenografted in nude mice, as compared to the EpCAM-specific mAb CO17-1A. Our results support the feasibility of producing anti-cancer recombinant vaccines using plant expression systems.

Published
2007

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