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1. Ocular and Oral Complications

Author

Steven, Philipp, Mays, Jacqueline W., Hashmi, Shahrukh K., Sureda, Anna, editor, Corbacioglu, Selim, editor, Greco, Raffaella, editor, Kröger, Nicolaus, editor, and Carreras, Enric, editor

Published
2024
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5. The novel role of lymphatic vessels in the pathogenesis of ocular diseases

Author

Clahsen, Thomas, Hadrian, Karina, Notara, Maria, Schlereth, Simona L., Howaldt, Antonia, Prokosch, Verena, Volatier, Thomas, Hos, Deniz, Schroedl, Falk, Kaser-Eichberger, Alexandra, Heindl, Ludwig M., Steven, Philipp, Bosch, Jacobus J., Steinkasserer, Alexander, Rokohl, Alexander C., Liu, Hanhan, Mestanoglu, Mert, Kashkar, Hamid, Schumacher, Björn, Kiefer, Friedemann, Schulte-Merker, Stefan, Matthaei, Mario, Hou, Yanhong, Fassbender, Sonja, Jantsch, Jonathan, Zhang, Wei, Enders, Philip, Bachmann, Björn, Bock, Felix, and Cursiefen, Claus

Published
2023
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13. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2020 Highly morbid forms report

Author

Wolff, Daniel, Radojcic, Vedran, Lafyatis, Robert, Cinar, Resat, Rosenstein, Rachel K., Cowen, Edward W., Cheng, Guang-Shing, Sheshadri, Ajay, Bergeron, Anne, Williams, Kirsten M., Todd, Jamie L., Teshima, Takanori, Cuvelier, Geoffrey D.E., Holler, Ernst, McCurdy, Shannon R., Jenq, Robert R., Hanash, Alan M., Jacobsohn, David, Santomasso, Bianca D., Jain, Sandeep, Ogawa, Yoko, Steven, Philipp, Luo, Zhonghui Katie, Dietrich-Ntoukas, Tina, Saban, Daniel, Bilic, Ervina, Penack, Olaf, Griffith, Linda M., Cowden, Meredith, Martin, Paul J., Greinix, Hildegard T., Sarantopoulos, Stefanie, Socie, Gerard, Blazar, Bruce R., Pidala, Joseph, Kitko, Carrie L., Couriel, Daniel R., Cutler, Corey, Schultz, Kirk R., Pavletic, Steven Z., Lee, Stephanie J., and Paczesny, Sophie

Published
2021
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14. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report

Author

Kitko, Carrie L., Pidala, Joseph, Schoemans, Hélène M., Lawitschka, Anita, Flowers, Mary E., Cowen, Edward W., Tkaczyk, Eric, Farhadfar, Nosha, Jain, Sandeep, Steven, Philipp, Luo, Zhonghui K., Ogawa, Yoko, Stern, Michael, Yanik, Greg A., Cuvelier, Geoffrey D.E., Cheng, Guang-Shing, Holtan, Shernan G., Schultz, Kirk R., Martin, Paul J., Lee, Stephanie J., Pavletic, Steven Z., Wolff, Daniel, Paczesny, Sophie, Blazar, Bruce R., Sarantopoulos, Stephanie, Socie, Gerard, Greinix, Hildegard, and Cutler, Corey

Published
2021
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22. Einführung

Author

Assadian, Ojan, Bialasiewicz, Alexander A., Falke, Karen, Guthoff, R. F., Kramer, Axel, Peschel, Sabine, Pleyer, Uwe, Seitz, Berthold, Steven, Philipp, Szentmáry, Nóra, Zhivov, Andrey, and Pleyer, Uwe, editor

Published
2014
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31. Clinical Dry Eye and Meibomian Gland Features Among Dry Eye Patients in Rural and Urban Ghana

Author

Osae, Eugene Appenteng, Ablordeppey, Reynolds Kwame, Horstmann, Jens, Kumah, David Ben, and Steven, Philipp

Subjects
dry eye, ocular surface, dysfunctional tear syndrome, Clinical Ophthalmology, meibomian gland dysfunction, Original Research
Abstract

Eugene Appenteng Osae,1,2 Reynolds Kwame Ablordeppey,1 Jens Horstmann,2 David Ben Kumah,1 Philipp Steven2,3 1Department of Optometry and Visual Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; 2Department of Ophthalmology, Division for Dry-Eye and Ocular GvHD, Medical Faculty, University of Cologne, Cologne, Germany; 3Cluster of Excellence: Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, GermanyCorrespondence: Eugene Appenteng OsaeDepartment of Optometry and Visual Science, Kwame Nkrumah University of Science and Technology, Private Mail Bag, Kumasi, GhanaTel +233 200 466 637Email osaeappen@gmail.comAim: To compare differences in clinical dry eye features and meibomian gland health status between dry eye patients from rural and urban populations in Ghana.Methods: We examined 211 (rural=109, urban=102) participants with subjective dry eye symptoms. Tear film break -up time (TBUT), Schirmer’s test and ocular surface staining (OSS) were assessed. Symptoms were evaluated using the SPEED II questionnaire. Meibomian glands (MG) in the right eye upper (UL) and lower lids (LL) were imaged using a custom meibographer. MG area was determined by intensity threshold segmentation using Image J software. MG loss (MGL) was also graded based on Pult’s grading scheme. Mann–Whitney, Spearman correlation, chi-square and odds analyses were performed; p< 0.05 was considered significant.Results: Rural participants showed greater SPEED scores, reduced TBUT, and lower Schirmer scores, p < 0.05. The proportion of rural participants with MGL were significantly more (82.3%) than urban participants (63.3%), p < 0.05. They also showed greater MGL than urban participants, p < 0.05. Chi-square test revealed significantly different meiboscale distributions (UL: χ2=13.58, LL: χ2=15.29) between the groups, p < 0.05. Overall significant relationships were observed between MGL and age [rs= 0.61], OSS [rs= 0.35], TBUT [rs= − 0.52], and Schirmer scores [rs= − 0.40], p < 0.05.Conclusion: The data suggest that the participants from the rural population have worse dry eye and meibomian gland health status than those from the urban population. The significant relationships between the various clinical variables suggest important links between MGD and DED. Subtle differences in the everyday working and living environment could likely account for the differences in the severity of DED and MGD between the two groups. And considering the increased pattern of urbanization, industrialization and modernization and the related environmental effects in Africa, future longitudinal studies on specific environmental risk factors or mediators of DED and MGD are necessary to ascertain the MGD and DED situation in Ghana and Africa at large.Keywords: dry eye, meibomian gland dysfunction, ocular surface, dysfunctional tear syndrome

Published
2020

33. [kumulative Dissertation]

Author

Steven, Philipp, Universitätsklinikum Köln. Klinik Und Poliklinik Für Allgemeine Augenheilkunde, Tahmaz, Volkan, and Scheid, Christoph

Subjects
Medizin und Gesundheit
Published
2022
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35. Okuläre Graft-Versus-Host Erkrankung: Leitlinie der Deutschen Ophthalmologischen Gesellschaft (DOG) und des Berufsverbands der Augenärzte Deutschlands e. V. (BVA).

Author

Deutsche Ophthalmologische Gesellschaft (DOG), Bertram, Bernd, Claessens, Daniela, Cursiefen, Claus, Dietrich-Ntoukas, Tina, Eberwein, Philipp, Ostrowski, Angelika, Seitz, Berthold, Steven, Philipp, Uhlig, Constantin, and Westekemper, Henrike

Abstract

Copyright of Die Ophthalmologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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36. A Novel Ferroptosis Inhibitor UAMC-3203, a Potential Treatment for Corneal Epithelial Wound.

Author

Balla, Anusha, Tran, Bao, Valtari, Annika, Steven, Philipp, Scarpellini, Camilla, Augustyns, Koen, Urtti, Arto, Vellonen, Kati-Sisko, and Ruponen, Marika

Subjects
WOUND healing, CORNEA injuries, SUMATRIPTAN, OPTICAL coherence tomography, TOPICAL drug administration, OCULAR injuries, INSPECTION & review
Abstract

Corneal wound, associated with pain, impaired vision, and even blindness, is the most common ocular injury. In this study, we investigated the effect of a novel ferroptosis inhibitor, UAMC-3203 (10 nM–50 µM), in corneal epithelial wound healing in vitro in human corneal epithelial (HCE) cells and ex vivo using alkali-induced corneal wounded mice eye model. We evaluated in vivo acute tolerability of the compound by visual inspection, optical coherence tomography (OCT), and stereomicroscope imaging in rats after its application (100 µM drug solution in phosphate buffer pH 7.4) twice a day for 5 days. In addition, we studied the partitioning of UAMC-3203 in corneal epithelium and corneal stroma using excised porcine cornea. Our study demonstrated that UAMC-3203 had a positive corneal epithelial wound healing effect at the optimal concentration of 10 nM (IC50 value for ferroptosis) in vitro and at 10 µM in the ex vivo study. UAMC-3203 solution (100 µM) was well tolerated after topical administration with no signs of toxicity and inflammation in rats. Ex-vivo distribution study revealed significantly higher concentration (~12–38-fold) and partition coefficient (Kp) (~52 times) in corneal epithelium than corneal stroma. The UAMC-3203 solution (100 µM) was stable for up to 30 days at 4 °C, 37 °C, and room temperature. Overall, UAMC-3203 provides a new prospect for safe and effective therapy for corneal wounds. [ABSTRACT FROM AUTHOR]

Published
2023
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