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3. A metagenomic analysis for combination therapy of multiple classes of antibiotics on the prevention of the spread of antibiotic-resistant genes

Author

Igo, Matthew, primary, Xu, Lei, additional, Krishna, Ashok, additional, Stewart, Sharron, additional, Xu, Lin, additional, Li, Zhihua, additional, Weaver, James L., additional, Stone, Heather, additional, Sacks, Leonard, additional, Bensman, Timothy, additional, Florian, Jeffry, additional, Rouse, Rodney, additional, and Han, Xiaomei, additional

Published
2023
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9. Application of Mechanistic Ocular Absorption Modeling and Simulation to Understand the Impact of Formulation Properties on Ophthalmic Bioavailability in Rabbits: a Case Study Using Dexamethasone Suspension

Author

Le Merdy, Maxime, Fan, Jianghong, Bolger, Michael B., Lukacova, Viera, Spires, Jessica, Tsakalozou, Eleftheria, Patel, Vikram, Xu, Lin, Stewart, Sharron, Chockalingam, Ashok, Narayanasamy, Suresh, Rouse, Rodney, Matta, Murali, Babiskin, Andrew, Kozak, Darby, Choi, Stephanie, Zhang, Lei, Lionberger, Robert, and Zhao, Liang

Published
2019
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13. Effects of sedative psychotropic drugs combined with oxycodone on respiratory depression in the rat

Author

Xu, Lin, primary, Krishna, Ashok, additional, Stewart, Sharron, additional, Shea, Katherine, additional, Racz, Rebecca, additional, Weaver, James L., additional, Volpe, Donna A., additional, Pilli, Nageswara R., additional, Narayanasamy, Suresh, additional, Florian, Jeffry, additional, Patel, Vikram, additional, Matta, Murali K., additional, Stone, Marc B., additional, Zhu, Hao, additional, Davis, Michael C., additional, Strauss, David G., additional, and Rouse, Rodney, additional

Published
2021
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17. Additional file 1 of The effect of antibiotics on the gut microbiome: a metagenomics analysis of microbial shift and gut antibiotic resistance in antibiotic treated mice

Author

Xu, Lei, Surathu, Anil, Raplee, Isaac, Chockalingam, Ashok, Stewart, Sharron, Walker, Lacey, Sacks, Leonard, Patel, Vikram, Zhihua Li, and Rouse, Rodney

Abstract

Additional file 1: Supplementary Figure 1. Principle Coordinate Analysis (PCoaA) based on Bray–Curtis dissimilarity of ARG abundances for all sample groups across all three cohorts Ampicillin (A), Ciprofloxacin (B), and Fosfomycin (C). Supplementary Table 1. Sample read counts. Supplementary Table 7. Shared species.

Published
2020
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22. Additional file 1: Figure S1. of Evaluating the potential of gold, silver, and silica nanoparticles to saturate mononuclear phagocytic system tissues under repeat dosing conditions

Author

Weaver, James, Grainne Tobin, Ingle, Taylor, Bancos, Simona, Stevens, David, Rouse, Rodney, Howard, Kristina, Goodwin, David, Knapton, Alan, Xiaohong Li, Shea, Katherine, Stewart, Sharron, Xu, Lin, Goering, Peter, Zhang, Qin, Howard, Paul, Collins, Jessie, Khan, Saeed, Kidon Sung, and Tyner, Katherine

Abstract

Schematic of experimental design. Note NP treatment is for each of the three NPs tested (e.g. 56 animals for AuNPs, 56 animals for AgNPs, 56 animals for SiO2 NPs). Note that this scheme does not take into account the extra animals that were dosed to allow for sufficient animal numbers at the end of the study (e.g. due to mis-dosing or animal death). Figure S2. DLS stability evaluation of NP dosing solutions. NPs were dispersed into D5W at representative dosing concentrations. DLS histograms were recorded up to 72Â h after initial dilution. Representative histograms for A) AuNPs B) AgNPs C) SiO2 NPs. Dosing took no longer than 3.5Â h for any NP. Table S1. Staining template for splenocyte analysis. Table S2. Summary Incidence Tables for AuNPs. Table S2. Summary Incidence Tables for AgNPs. Table S4. Summary Incidence Tables for SiO2NPs. (DOC 664Â kb)

Published
2017
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24. Determination of Non-Transferrin Bound Iron, Transferrin Bound Iron, Drug Bound Iron and Total Iron in Serum in a Rats after IV Administration of Sodium Ferric Gluconate Complex by Simple Ultrafiltration Inductively Coupled Plasma Mass Spectrometric Detection

Author

Matta, Murali, primary, Beekman, Christopher, additional, Gandhi, Adarsh, additional, Narayanasamy, Suresh, additional, Thomas, Christopher, additional, Mohammad, Adil, additional, Stewart, Sharron, additional, Xu, Lin, additional, Chockalingam, Ashok, additional, Shea, Katherine, additional, Patel, Vikram, additional, and Rouse, Rodney, additional

Published
2018
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27. Comparative Evaluation of U.S. Brand and Generic Intravenous Sodium Ferric Gluconate Complex in Sucrose Injection: Biodistribution after Intravenous Dosing in Rats

Author

Beekman, Christopher, primary, Matta, Murali, additional, Thomas, Christopher, additional, Mohammad, Adil, additional, Stewart, Sharron, additional, Xu, Lin, additional, Chockalingam, Ashok, additional, Shea, Katherine, additional, Sun, Dajun, additional, Jiang, Wenlei, additional, Patel, Vikram, additional, and Rouse, Rodney, additional

Published
2017
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28. Autophagy in Pancreatic Acinar Cells in Caerulein-treated Mice

Author

Stewart Sharron, Grainne A. McMahon Tobin, Jun Zhang, Rodney Rouse, Lin Xu, Alan Knapton, Katherine Shea, and Leshuai W. Zhang

Subjects
Male, Pathology, medicine.medical_specialty, Acinar Cells, Biology, Toxicology, Pathology and Forensic Medicine, Mice, Necrosis, Lysosome, Autophagy, medicine, Acinar cell, Animals, Pancreas, Molecular Biology, Ceruletide, TUNEL assay, Proteins, Lipase, Cell Biology, medicine.disease, Immunohistochemistry, Molecular biology, Mice, Inbred C57BL, medicine.anatomical_structure, Pancreatitis, Membrane protein, Amylases, Biomarkers
Abstract

Drug-induced pancreatitis (DIP) is an underdiagnosed condition that lacks sensitive and specific biomarkers. To better understand the mechanisms of DIP and to identify potential tissue biomarkers, we studied experimental pancreatitis induced in male C57BL/6 mice by intraperitoneal injection of caerulein (10 or 50 μg/kg) at 1-hr intervals for a total of 7 injections. Pancreata from caerulein-treated mice exhibited consistent acinar cell autophagy and apoptosis with infrequent necrosis. Kinetic assays for serum amylase and lipase also showed a dose-dependent increase. Terminal deoxynucleotidyl transferase–mediated biotin-dNTP nick labeling (TUNEL) detected dose-dependent acinar cell apoptosis. By light microscopy, autophagy was characterized by the formation of autophagosomes and autolysosomes (ALs) within the cytoplasm of acinar cells. Immunohistochemical studies with specific antibodies for proteins related to autophagy and pancreatic stress were conducted to evaluate these proteins as potential biomarkers of pancreatitis. Western blots were used to confirm immunohistochemical results using pancreatic lysates from control and treated animals. Autophagy was identified as a contributing process in caerulein-induced pancreatitis and proteins previously associated with autophagy were upregulated following caerulein treatment. Autophagosomes and ALs were found to be a common pathway, in which cathepsins, lysosome-associated membrane protein 2, vacuole membrane protein 1, microtubule-associated protein 1 light chain 3 (LC3), autophagy-related protein 9, Beclin1,andpancreatitis-associated proteins were simultaneously involved in response to caerulein stimulus. Regenerating islet-derived 3 gamma (Reg3γ), a pancreatic acute response protein, was dose-dependently induced in caerulein-treated mice and colocalized with the autophagosomal marker, LC3. This finding supports Reg3γ as a candidate biomarker for pancreatic injury.

Published
2013

29. Evaluating the potential of gold, silver, and silica nanoparticles to saturate mononuclear phagocytic system tissues under repeat dosing conditions

Author

Weaver, James L., primary, Tobin, Grainne A., additional, Ingle, Taylor, additional, Bancos, Simona, additional, Stevens, David, additional, Rouse, Rodney, additional, Howard, Kristina E., additional, Goodwin, David, additional, Knapton, Alan, additional, Li, Xiaohong, additional, Shea, Katherine, additional, Stewart, Sharron, additional, Xu, Lin, additional, Goering, Peter L., additional, Zhang, Qin, additional, Howard, Paul C., additional, Collins, Jessie, additional, Khan, Saeed, additional, Sung, Kidon, additional, and Tyner, Katherine M., additional

Published
2017
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30. Comparative Evaluation of U.S. Brand and Generic Intravenous Sodium Ferric Gluconate Complex in Sucrose Injection: Biodistribution after Intravenous Dosing in Rats.

Author

Beekman, Christopher R., Matta, Murali K., Thomas, Christopher D., Mohammad, Adil, Stewart, Sharron, Xu, Lin, Chockalingam, Ashok, Shea, Katherine, Sun, Dajun, Jiang, Wenlei, Patel, Vikram, and Rouse, Rodney

Subjects
THERAPEUTIC equivalency in drugs, THERAPEUTIC use of iron, INTRAVENOUS therapy
Abstract

Relative biodistribution of FDA-approved innovator and generic sodium ferric gluconate (SFG) drug products was investigated to identify differences in tissue distribution of iron after intravenous dosing to rats. Three equal cohorts of 42 male Sprague-Dawley rats were created with each cohort receiving one of three treatments: (1) the innovator SFG product dosed intravenously at a concentration of 40 mg/kg; (2) the generic SFG product dosed intravenously at a concentration of 40 mg/kg; (3) saline dosed intravenously at equivalent volume to SFG products. Sampling time points were 15 min, 1 h, 8 h, 1 week, two weeks, four weeks, and six weeks post-treatment. Six rats from each group were sacrificed at each time point. Serum, femoral bone marrow, lungs, brain, heart, kidneys, liver, and spleen were harvested and evaluated for total iron concentration by ICP-MS. The ICP-MS analytical method was validated with linearity, range, accuracy, and precision. Results were determined for mean iron concentrations (µg/g) and mean total iron (whole tissue) content (µg/tissue) for each tissue of all groups at each time point. A percent of total distribution to each tissue was calculated for both products. At any given time point, the overall percent iron concentration distribution did not vary between the two SFG drugs by more than 7% in any tissue. Overall, this study demonstrated similar tissue biodistribution for the two SFG products in the examined tissues. [ABSTRACT FROM AUTHOR]

Published
2018
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35. 56th Sig Bn assists in Katrina disaster relief

Author

Stewart, Sharron

Subjects
Hurricane Katrina, 2005 -- Management -- Influence, Natural disasters -- Influence -- United States, Soldiers -- Services, Disaster relief -- Management -- United States, Company business management, Electronics, Military and naval science
Abstract

Like a Phoenix rising from the ashes, the city of New Orleans steadily rises from the mire and goes about the mission of restoring order to her citizens. Soldiers of [...]

Published
2006

37. Comparison of the Diagnostic Accuracy of Di-22:6-Bis(monoacylglycerol)Phosphate and Other Urinary Phospholipids for Drug-Induced Phospholipidosis or Tissue Injury in the Rat

Author

Thompson, Karol L., primary, Haskins, Kylie, additional, Rosenzweig, Barry A., additional, Stewart, Sharron, additional, Zhang, Jun, additional, Peters, David, additional, Knapton, Alan, additional, Rouse, Rodney, additional, Mans, Daniel, additional, and Colatsky, Thomas, additional

Published
2012
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