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2. Visual Outcomes Following Plasma Exchange for Optic Neuritis: An International Multicenter Retrospective Analysis of 395 Optic Neuritis Attacks.

Author

Chen, John, Flanagan, Eoin, Pittock, Sean, Stern, Nicole, Tisavipat, Nanthaya, Bhatti, M, Chodnicki, Kevin, Tajfirouz, Deena, Jamali, Sepideh, Kunchok, Amy, Eggenberger, Eric, Nome, Marie, Sotirchos, Elias, Vasileiou, Eleni, Henderson, Amanda, Arnold, Anthony, Bonelli, Laura, Moss, Heather, Navarro, Sylvia, Padungkiatsagul, Tanyatuth, Stiebel-Kalish, Hadas, Lotan, Itay, Wilf-Yarkoni, Adi, Danesh-Meyer, Helen, Ivanov, Stefan, Huda, Saif, Forcadela, Mirasol, Hodge, David, Poullin, Pascale, Rode, Julie, Papeix, Caroline, Saheb, Samir, Boudot de la Motte, Marine, Vignal, Catherine, Hacohen, Yael, Pique, Julie, Maillart, Elisabeth, Deschamps, Romain, Audoin, Bertrand, and Marignier, Romain

Subjects
Humans, Female, Male, Plasma Exchange, Retrospective Studies, Myelin-Oligodendrocyte Glycoprotein, Optic Neuritis, Neuromyelitis Optica, Vision Disorders, Autoantibodies
Abstract

PURPOSE: To evaluate the effectiveness of plasma exchange (PLEX) for optic neuritis (ON). METHODS: We conducted an international multicenter retrospective study evaluating the outcomes of ON following PLEX. Outcomes were compared to raw data from the Optic Neuritis Treatment Trial (ONTT) using a matched subset. RESULTS: A total of 395 ON attack treated with PLEX from 317 patients were evaluated. The median age was 37 years (range 9-75), and 71% were female. Causes of ON included multiple sclerosis (108), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) (92), aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD) (75), seronegative-NMOSD (34), idiopathic (83), and other (3). Median time from onset of vision loss to PLEX was 2.6 weeks (interquartile range [IQR], 1.4-4.0). Median visual acuity (VA) at the time of PLEX was count fingers (IQR, 20/200-hand motion), and median final VA was 20/25 (IQR, 20/20-20/60) with no differences among etiologies except MOGAD-ON, which had better outcomes. In 81 (20.5%) ON attacks, the final VA was 20/200 or worse. Patients with poor outcomes were older (P = .002), had worse VA at the time of PLEX (P < .001), and longer delay to PLEX (P < .001). In comparison with the ONTT subset with severe corticosteroid-unresponsive ON, a final VA of worse than 20/40 occurred in 6 of 50 (12%) PLEX-treated ON vs 7 of 19 (37%) from the ONTT treated with intravenous methylprednisolone without PLEX (P = .04). CONCLUSION: Most ON attacks improved with PLEX, and outcomes were better than attacks with similar severity in the ONTT. The presence of severe vision loss at nadir, older age, and longer delay to PLEX predicted a worse outcome whereas MOGAD-ON had a more favorable prognosis. NOTE: Publication of this article is sponsored by the American Ophthalmological Society.

Published
2023

4. OCT retinal nerve fiber layer thickness differentiates acute optic neuritis from MOG antibody-associated disease and Multiple Sclerosis RNFL thickening in acute optic neuritis from MOGAD vs MS

Author

Chen, John J, Sotirchos, Elias S, Henderson, Amanda D, Vasileiou, Eleni S, Flanagan, Eoin P, Bhatti, M Tariq, Jamali, Sepideh, Eggenberger, Eric R, Dinome, Marie, Frohman, Larry P, Arnold, Anthony C, Bonelli, Laura, Seleme, Nicolas, Mejia-Vergara, Alvaro J, Moss, Heather E, Padungkiatsagul, Tanyatuth, Stiebel-Kalish, Hadas, Lotan, Itay, Hellmann, Mark A, Hodge, Dave, Oertel, Frederike Cosima, Paul, Friedemann, Saidha, Shiv, Calabresi, Peter A, and Pittock, Sean J

Subjects
Clinical Research, Brain Disorders, Autoimmune Disease, Eye Disease and Disorders of Vision, Multiple Sclerosis, Neurosciences, Neurodegenerative, Neurological, Adult, Cross-Sectional Studies, Female, Humans, Middle Aged, Nerve Fibers, Optic Neuritis, Tomography, Optical Coherence, Myelin oligodendrocyte glycoprotein, MOG antibody-associated disease, Optic neuritis, Optical coherence tomography, Peripapillary retinal nerve fiber layer
Abstract

BackgroundOptic neuritis (ON) is the most common manifestation of myelin oligodendrocyte glycoprotein antibody associated disorder (MOGAD) and multiple sclerosis (MS). Acute ON in MOGAD is thought to be associated with more severe optic disk edema than in other demyelinating diseases, but this has not been quantitatively confirmed. The goal of this study was to determine whether optical coherence tomography (OCT) can distinguish acute ON in MOGAD from MS, and establish the sensitivity of OCT as a confirmatory biomarker of ON in these entities.MethodsThis was a multicenter cross-sectional study of MOGAD and MS patients with peripapillary retinal nerve fiber layer (pRNFL) thickness measured with OCT within two weeks of acute ON symptom. Cirrus HD-OCT (Carl Zeiss Meditec, Inc. Dublin, CA, USA) was used to measure the pRNFL during acute ON. Eyes with prior ON or disk pallor were excluded. A receiver operating characteristic (ROC) curve analysis was performed to assess the ability of pRNFL thickness to distinguish MOGAD from MS.ResultsSixty-four MOGAD and 50 MS patients met study inclusion criteria. Median age was 46.5 years (interquartile range [IQR]: 34.3-57.0) for the MOGAD group and 30.4 years (IQR: 25.7-38.4) for the MS group (p

Published
2022

5. Astrocytic outer retinal layer thinning is not a feature in AQP4-IgG seropositive neuromyelitis optica spectrum disorders

Author

Lu, Angelo, Zimmermann, Hanna G, Specovius, Svenja, Motamedi, Seyedamirhosein, Chien, Claudia, Bereuter, Charlotte, Lana-Peixoto, Marco A, Fontenelle, Mariana Andrade, Ashtari, Fereshteh, Kafieh, Rahele, Dehghani, Alireza, Pourazizi, Mohsen, Pandit, Lekha, D'Cunha, Anitha, Kim, Ho Jin, Hyun, Jae-Won, Jung, Su-Kyung, Leocani, Letizia, Pisa, Marco, Radaelli, Marta, Siritho, Sasitorn, May, Eugene F, Tongco, Caryl, De Sèze, Jérôme, Senger, Thomas, Palace, Jacqueline, Roca-Fernández, Adriana, Leite, Maria Isabel, Sharma, Srilakshmi M, Stiebel-Kalish, Hadas, Asgari, Nasrin, Soelberg, Kerstin Kathrine, Martinez-Lapiscina, Elena H, Havla, Joachim, Mao-Draayer, Yang, Rimler, Zoe, Reid, Allyson, Marignier, Romain, Cobo-Calvo, Alvaro, Altintas, Ayse, Tanriverdi, Uygur, Yildirim, Rengin, Aktas, Orhan, Ringelstein, Marius, Albrecht, Philipp, Tavares, Ivan Maynart, Bichuetti, Denis Bernardi, Jacob, Anu, Huda, Saif, de Castillo, Ibis Soto, Petzold, Axel, Green, Ari J, Yeaman, Michael R, Smith, Terry J, Cook, Lawrence, Paul, Friedemann, Brandt, Alexander U, and Oertel, Frederike Cosima

Subjects
Eye Disease and Disorders of Vision, Brain Disorders, Neurosciences, Neurodegenerative, Adult, Aquaporin 4, Astrocytes, Autoantibodies, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Neuromyelitis Optica, Retina, Tomography, Optical Coherence, vision, clinical neurology, ophthalmology, GJCF International Clinical Consortium for NMOSD, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract

BackgroundPatients with anti-aquaporin-4 antibody seropositive (AQP4-IgG+) neuromyelitis optica spectrum disorders (NMOSDs) frequently suffer from optic neuritis (ON) leading to severe retinal neuroaxonal damage. Further, the relationship of this retinal damage to a primary astrocytopathy in NMOSD is uncertain. Primary astrocytopathy has been suggested to cause ON-independent retinal damage and contribute to changes particularly in the outer plexiform layer (OPL) and outer nuclear layer (ONL), as reported in some earlier studies. However, these were limited in their sample size and contradictory as to the localisation. This study assesses outer retinal layer changes using optical coherence tomography (OCT) in a multicentre cross-sectional cohort.Method197 patients who were AQP4-IgG+ and 32 myelin-oligodendrocyte-glycoprotein antibody seropositive (MOG-IgG+) patients were enrolled in this study along with 75 healthy controls. Participants underwent neurological examination and OCT with central postprocessing conducted at a single site.ResultsNo significant thinning of OPL (25.02±2.03 µm) or ONL (61.63±7.04 µm) were observed in patients who were AQP4-IgG+ compared with patients who were MOG-IgG+ with comparable neuroaxonal damage (OPL: 25.10±2.00 µm; ONL: 64.71±7.87 µm) or healthy controls (OPL: 24.58±1.64 µm; ONL: 63.59±5.78 µm). Eyes of patients who were AQP4-IgG+ (19.84±5.09 µm, p=0.027) and MOG-IgG+ (19.82±4.78 µm, p=0.004) with a history of ON showed parafoveal OPL thinning compared with healthy controls (20.99±5.14 µm); this was not observed elsewhere.ConclusionThe results suggest that outer retinal layer loss is not a consistent component of retinal astrocytic damage in AQP4-IgG+ NMOSD. Longitudinal studies are necessary to determine if OPL and ONL are damaged in late disease due to retrograde trans-synaptic axonal degeneration and whether outer retinal dysfunction occurs despite any measurable structural correlates.

Published
2022

6. Retinal Optical Coherence Tomography in Neuromyelitis Optica.

Author

Oertel, Frederike, Specovius, Svenja, Zimmermann, Hanna, Chien, Claudia, Motamedi, Seyedamirhosein, Bereuter, Charlotte, Cook, Lawrence, Lana Peixoto, Marco, Fontanelle, Mariana, Kim, Ho, Hyun, Jae-Won, Palace, Jacqueline, Roca-Fernandez, Adriana, Leite, Maria, Sharma, Srilakshmi, Ashtari, Fereshteh, Kafieh, Rahele, Dehghani, Alireza, Pourazizi, Mohsen, Pandit, Lekha, DCunha, Anitha, Aktas, Orhan, Ringelstein, Marius, Albrecht, Philipp, May, Eugene, Tongco, Caryl, Leocani, Letizia, Pisa, Marco, Radaelli, Marta, Martinez-Lapiscina, Elena, Stiebel-Kalish, Hadas, Siritho, Sasitorn, de Seze, Jérome, Senger, Thomas, Havla, Joachim, Marignier, Romain, Cobo-Calvo, Alvaro, Bichuetti, Denis, Tavares, Ivan, Asgari, Nasrin, Soelberg, Kerstin, Altintas, Ayse, Yildirim, Rengin, Tanriverdi, Uygur, Jacob, Anu, Huda, Saif, Rimler, Zoe, Reid, Allyson, Mao-Draayer, Yang, Soto de Castillo, Ibis, Petzold, Axel, Green, Ari, Yeaman, Michael, Smith, Terry, Brandt, Alexander, and Paul, Friedemann

Subjects
Adult, Aquaporin 4, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Neuromyelitis Optica, Optic Neuritis, Retinal Neurons, Retrospective Studies, Tomography, Optical Coherence, Young Adult
Abstract

BACKGROUND AND OBJECTIVES: To determine optic nerve and retinal damage in aquaporin-4 antibody (AQP4-IgG)-seropositive neuromyelitis optica spectrum disorders (NMOSD) in a large international cohort after previous studies have been limited by small and heterogeneous cohorts. METHODS: The cross-sectional Collaborative Retrospective Study on retinal optical coherence tomography (OCT) in neuromyelitis optica collected retrospective data from 22 centers. Of 653 screened participants, we included 283 AQP4-IgG-seropositive patients with NMOSD and 72 healthy controls (HCs). Participants underwent OCT with central reading including quality control and intraretinal segmentation. The primary outcome was thickness of combined ganglion cell and inner plexiform (GCIP) layer; secondary outcomes were thickness of peripapillary retinal nerve fiber layer (pRNFL) and visual acuity (VA). RESULTS: Eyes with ON (NMOSD-ON, N = 260) or without ON (NMOSD-NON, N = 241) were assessed compared with HCs (N = 136). In NMOSD-ON, GCIP layer (57.4 ± 12.2 μm) was reduced compared with HC (GCIP layer: 81.4 ± 5.7 μm, p < 0.001). GCIP layer loss (-22.7 μm) after the first ON was higher than after the next (-3.5 μm) and subsequent episodes. pRNFL observations were similar. NMOSD-NON exhibited reduced GCIP layer but not pRNFL compared with HC. VA was greatly reduced in NMOSD-ON compared with HC eyes, but did not differ between NMOSD-NON and HC. DISCUSSION: Our results emphasize that attack prevention is key to avoid severe neuroaxonal damage and vision loss caused by ON in NMOSD. Therapies ameliorating attack-related damage, especially during a first attack, are an unmet clinical need. Mild signs of neuroaxonal changes without apparent vision loss in ON-unaffected eyes might be solely due to contralateral ON attacks and do not suggest clinically relevant progression but need further investigation.

Published
2021

7. Cohort profile: a collaborative multicentre study of retinal optical coherence tomography in 539 patients with neuromyelitis optica spectrum disorders (CROCTINO).

Author

Specovius, Svenja, Zimmermann, Hanna G, Oertel, Frederike Cosima, Chien, Claudia, Bereuter, Charlotte, Cook, Lawrence J, Lana Peixoto, Marco Aurélio, Fontenelle, Mariana Andrade, Kim, Ho Jin, Hyun, Jae-Won, Jung, Su-Kyung, Palace, Jacqueline, Roca-Fernandez, Adriana, Diaz, Alejandro Rubio, Leite, Maria Isabel, Sharma, Srilakshmi M, Ashtari, Fereshte, Kafieh, Rahele, Dehghani, Alireza, Pourazizi, Mohsen, Pandit, Lekha, Dcunha, Anitha, Aktas, Orhan, Ringelstein, Marius, Albrecht, Philipp, May, Eugene, Tongco, Caryl, Leocani, Letizia, Pisa, Marco, Radaelli, Marta, Martinez-Lapiscina, Elena H, Stiebel-Kalish, Hadas, Hellmann, Mark, Lotan, Itay, Siritho, Sasitorn, de Seze, Jérôme, Senger, Thomas, Havla, Joachim, Marignier, Romain, Tilikete, Caroline, Cobo Calvo, Alvaro, Bichuetti, Denis Bernardi, Tavares, Ivan Maynart, Asgari, Nasrin, Soelberg, Kerstin, Altintas, Ayse, Yildirim, Rengin, Tanriverdi, Uygur, Jacob, Anu, Huda, Saif, Rimler, Zoe, Reid, Allyson, Mao-Draayer, Yang, de Castillo, Ibis Soto, Yeaman, Michael R, Smith, Terry J, Brandt, Alexander U, Paul, Friedemann, and GJCF International Clinical Consortium for NMOSD

Subjects
GJCF International Clinical Consortium for NMOSD, medical retina, neuro-ophthalmology, neurology, radiology & imaging, radiology &amp, imaging, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences
Abstract

PurposeOptical coherence tomography (OCT) captures retinal damage in neuromyelitis optica spectrum disorders (NMOSD). Previous studies investigating OCT in NMOSD have been limited by the rareness and heterogeneity of the disease. The goal of this study was to establish an image repository platform, which will facilitate neuroimaging studies in NMOSD. Here we summarise the profile of the Collaborative OCT in NMOSD repository as the initial effort in establishing this platform. This repository should prove invaluable for studies using OCT to investigate NMOSD.ParticipantsThe current cohort includes data from 539 patients with NMOSD and 114 healthy controls. These were collected at 22 participating centres from North and South America, Asia and Europe. The dataset consists of demographic details, diagnosis, antibody status, clinical disability, visual function, history of optic neuritis and other NMOSD defining attacks, and OCT source data from three different OCT devices.Findings to dateThe cohort informs similar demographic and clinical characteristics as those of previously published NMOSD cohorts. The image repository platform and centre network continue to be available for future prospective neuroimaging studies in NMOSD. For the conduct of the study, we have refined OCT image quality criteria and developed a cross-device intraretinal segmentation pipeline.Future plansWe are pursuing several scientific projects based on the repository, such as analysing retinal layer thickness measurements, in this cohort in an attempt to identify differences between distinct disease phenotypes, demographics and ethnicities. The dataset will be available for further projects to interested, qualified parties, such as those using specialised image analysis or artificial intelligence applications.

Published
2020

8. Visual Outcomes Following Plasma Exchange for Optic Neuritis: An International Multicenter Retrospective Analysis of 395 Optic Neuritis Attacks

Author

Chen, John J., Flanagan, Eoin P., Pittock, Sean J., Stern, Nicole Caroline, Tisavipat, Nanthaya, Bhatti, M. Tariq, Chodnicki, Kevin D., Tajfirouz, Deena A., Jamali, Sepideh, Kunchok, Amy, Eggenberger, Eric R., Nome, Marie A. Di, Sotirchos, Elias S., Vasileiou, Eleni S., Henderson, Amanda D., Arnold, Anthony C., Bonelli, Laura, Moss, Heather E., Navarro, Sylvia Elizabeth Villarreal, Padungkiatsagul, Tanyatuth, Stiebel-Kalish, Hadas, Lotan, Itay, Wilf-Yarkoni, Adi, Danesh-Meyer, Helen, Ivanov, Stefan, Huda, Saif, Forcadela, Mirasol, Hodge, David, Poullin, Pascale, Rode, Julie, Papeix, Caroline, Saheb, Samir, Boudot de la Motte, Marine, Vignal, Catherine, Hacohen, Yael, Pique, Julie, Maillart, Elisabeth, Deschamps, Romain, Audoin, Bertrand, and Marignier, Romain

Published
2023
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9. Details and outcomes of a large cohort of MOG-IgG associated optic neuritis

Author

Chen, John J., Flanagan, Eoin P., Bhatti, M. Tariq, Tisavipat, Nanthaya, Jamali, Sepideh, Kunchok, Amy, Eggenberger, Eric R., Nome, Marie Di, Sotirchos, Elias S., Vasileiou, Eleni S., Henderson, Amanda D., Arnold, Anthony C., Bonelli, Laura, Seleme, Nicolas, Mejia-Vergara, Alvaro J., Moss, Heather E., Padungkiatsagul, Tanyatuth, Stiebel-Kalish, Hadas, Lotan, Itay, Wilf-Yarkoni, Adi, Hellmann, Mark A., Vuppala, Amrita, Hodge, David, and Pittock, Sean J.

Published
2022
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10. Diagnosis and classification of optic neuritis

Author

Petzold, Axel, Fraser, Clare L, Abegg, Mathias, Alroughani, Raed, Alshowaeir, Daniah, Alvarenga, Regina, Andris, Cécile, Asgari, Nasrin, Barnett, Yael, Battistella, Roberto, Behbehani, Raed, Berger, Thomas, Bikbov, Mukharram M, Biotti, Damien, Biousse, Valerie, Boschi, Antonella, Brazdil, Milan, Brezhnev, Andrei, Calabresi, Peter A, Cordonnier, Monique, Costello, Fiona, Cruz, Franz M, Cunha, Leonardo Provetti, Daoudi, Smail, Deschamps, Romain, de Seze, Jerome, Diem, Ricarda, Etemadifar, Masoud, Flores-Rivera, Jose, Fonseca, Pedro, Frederiksen, Jette, Frohman, Elliot, Frohman, Teresa, Tilikete, Caroline Froment, Fujihara, Kazuo, Gálvez, Alberto, Gouider, Riadh, Gracia, Fernando, Grigoriadis, Nikolaos, Guajardo, José M, Habek, Mario, Hawlina, Marko, Martínez-Lapiscina, Elena H, Hooker, Juzar, Hor, Jyh Yung, Howlett, William, Huang-Link, Yumin, Idrissova, Zhannat, Illes, Zsolt, Jancic, Jasna, Jindahra, Panitha, Karussis, Dimitrios, Kerty, Emilia, Kim, Ho Jin, Lagrèze, Wolf, Leocani, Letizia, Levin, Netta, Liskova, Petra, Liu, Yaou, Maiga, Youssoufa, Marignier, Romain, McGuigan, Chris, Meira, Dália, Merle, Harold, Monteiro, Mário L R, Moodley, Anand, Moura, Frederico, Muñoz, Silvia, Mustafa, Sharik, Nakashima, Ichiro, Noval, Susana, Oehninger, Carlos, Ogun, Olufunmilola, Omoti, Afekhide, Pandit, Lekha, Paul, Friedemann, Rebolleda, Gema, Reddel, Stephen, Rejdak, Konrad, Rejdak, Robert, Rodriguez-Morales, Alfonso J, Rougier, Marie-Bénédicte, Sa, Maria Jose, Sanchez-Dalmau, Bernardo, Saylor, Deanna, Shatriah, Ismail, Siva, Aksel, Stiebel-Kalish, Hadas, Szatmary, Gabriella, Ta, Linh, Tenembaum, Silvia, Tran, Huy, Trufanov, Yevgen, van Pesch, Vincent, Wang, An-Guor, Wattjes, Mike P, Willoughby, Ernest, Zakaria, Magd, Zvornicanin, Jasmin, Balcer, Laura, and Plant, Gordon T

Published
2022
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14. Acute Optic Neuropathy in Older Adults

Author

Tisavipat, Nanthaya, primary, Stiebel-Kalish, Hadas, additional, Palevski, Dahlia, additional, Bialer, Omer Y., additional, Moss, Heather E., additional, Chaitanuwong, Pareena, additional, Padungkiatsagul, Tanyatuth, additional, Henderson, Amanda D., additional, Sotirchos, Elias S., additional, Singh, Shonar, additional, Salman, Abdul-Rahman, additional, Tajfirouz, Deena A., additional, Chodnicki, Kevin D., additional, Pittock, Sean J., additional, Flanagan, Eoin P., additional, and Chen, John J., additional

Published
2024
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15. Protocol of a prospective multicenter study on comorbidity impact on multiple sclerosis and antibody-mediated diseases of the central nervous system (COMMIT).

Author

Samadzadeh, Sara, Adnan, Rafl, Berglova, Paulina, Barzegar, Mahdi, Debrabant, Birgit, Roikjaer, Stine Gundtoft, Levy, Michael, Petzold, Axel, Palace, Jacqueline, Flanagan, Eoin P., Mariotto, Sara, Skou, Soeren T., Froelich, Anne, Lotan, Itay, Messina, Silvia, Geraldes, Ruth, Asseyer, Susanna, Stiebel-Kalish, Hadas, Oertel, Frederike Cosima, and Shaygannejad, Vahid

Subjects
CENTRAL nervous system diseases, CENTRAL nervous system viral diseases, NEUROMYELITIS optica, MULTIPLE sclerosis, REVERSE transcriptase polymerase chain reaction, MYELIN oligodendrocyte glycoprotein
Abstract

Comorbidities in patients with multiple sclerosis (MS) and antibody-mediated diseases of the central nervous system (CNS) including neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein (MOG)- antibody-associated disease (MOGAD) are common and may influence the course of their neurological disease. Comorbidity may contribute to neuronal injury and therefore limit recovery from attacks, accelerate disease progression, and increase disability. This study aims to explore the impact of comorbidity, particularly vascular comorbidity, and related risk factors on clinical and paraclinical parameters of MS, NMOSD and MOGAD. We propose COMMIT, a prospective multicenter study with longitudinal follow-up of patients with MS, NMOSD, and MOGAD, with or without comorbidities, as well as healthy subjects as controls. Subjects will be stratified by age, sex and ethnicity. In consecutive samples we will analyze levels of inflammation and neurodegeneration markers in both fluid and cellular compartments of the peripheral blood and cerebrospinal fluid (CSF) using multiple state-of-the-art technologies, including untargeted proteomics and targeted ultrasensitive ELISA assays and quantitative reverse transcription polymerase chain reaction (RT-qPCR) as well as high-dimensional single-cell technologies i.e., mass cytometry and single-cell RNA sequencing. Algorithm-based data analyses will be used to unravel the relationship between these markers, optical coherence tomography (OCT) and magnetic resonance imaging (MRI), and clinical outcomes including frequency and severity of relapses, long-term disability, and quality of life. The goal is to evaluate the impact of comorbidities on MS, NMOSD, and MOGAD which may lead to development of treatment approaches to improve outcomes of inflammatory demyelinating diseases of the CNS. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Effectiveness of oral prednisone tapering following intravenous methylprednisolone for acute optic neuritis in multiple sclerosis

Author

Wilf-Yarkoni, Adi, primary, Feldmann, Kristina, additional, Rubarth, Kerstin, additional, Dorsch, Eva-Maria, additional, Rust, Rebekka, additional, Urman, Ilia, additional, Hellmann, Mark A., additional, Friedman, Yitzhak, additional, Lotan, Itay, additional, Bialer, Omer, additional, Buenrostro, Gilberto Solorza, additional, Zimmermann, Hanna G., additional, Leutloff, Carla, additional, Schmitz-Hübsch, Tanja, additional, Paul, Friedemann, additional, Asseyer, Susanna, additional, and Stiebel-Kalish, Hadas, additional

Published
2023
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18. Steroid-sparing maintenance immunotherapy for MOG-IgG associated disorder

Author

Chen, John J., Flanagan, Eoin P., Bhatti, M. Tariq, Jitprapaikulsan, Jiraporn, Dubey, Divyanshu, Lopez Chiriboga, Alfonso (Sebastian) S., Fryer, James P., Weinshenker, Brian G., McKeon, Andrew, Tillema, Jan-Mendelt, Lennon, Vanda A., Lucchinetti, Claudia F., Kunchok, Amy, McClelland, Collin M., Lee, Michael S., Bennett, Jeffrey L., Pelak, Victoria S., Van Stavern, Gregory, Adesina, Ore-Ofe O., Eggenberger, Eric R., Acierno, Marie D., Wingerchuk, Dean M., Lam, Byron L., Moss, Heather, Beres, Shannon, Gilbert, Aubrey L., Shah, Veeral, Armstrong, Grayson, Heidary, Gena, Cestari, Dean M., Stiebel-Kalish, Hadas, and Pittock, Sean J.

Published
2020
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21. Application of diagnostic criteria for optic neuritis – Authors' reply

Author

Petzold, Axel, primary, Liu, Yaou, additional, Fraser, Clare, additional, Abegg, Mathias, additional, Alroughani, Raed, additional, Alshowaeir, Daniah, additional, Alvarenga, Regina, additional, Andris, Cécile, additional, Asgari, Nasrin, additional, Barnett, Yael, additional, Battistella, Roberto, additional, Behbehani, Raed, additional, Berger, Thomas, additional, Bikbov, Mukharram M., additional, Biotti, Damien, additional, Biousse, Valerie, additional, Boschi, Antonella, additional, Brazdil, Milan, additional, Brezhnev, Andrei, additional, Calabresi, Peter, additional, Cordonnier, Monique, additional, Costello, Fiona, additional, Cruz, Franz Marie, additional, Cunha, Leonardo Provetti, additional, Daoudi, Smail, additional, Deschamps, Romain, additional, DeSeze, Jerome, additional, Diem, Ricarda, additional, Etemadifar, Masoud, additional, Flores-Rivera, Jose, additional, Fonseca, Pedro, additional, Frederiksen, Jette, additional, Frohman, Elliot, additional, Frohman, Teresa, additional, FromentTilikete, Caroline, additional, Fujihara, Kazuo, additional, Gálvez, Alberto, additional, Gouider, Riadh, additional, Gracia, Fernando, additional, Grigoriadis, Nikolaos, additional, Guajardo, José Manuel, additional, Habek, Mario, additional, Hawlina, Marko, additional, Hernández-Martínez de Lapiscina, Elena, additional, Hooker, Juzar, additional, Hor, Jyh Yung, additional, Howlett, William, additional, Huang-Link, Yumin, additional, Idrissova, Zhannat, additional, Illes, Zsolt, additional, Jancic, Jasna, additional, Jindahra, Panitha, additional, Karussis, Dimitrios, additional, Kerty, Emilia, additional, Kim, Ho Jin, additional, Lagrèze, Wolf, additional, Leocani, Letizia, additional, Levin, Netta, additional, Liskova, Petra, additional, Maiga, Youssoufa, additional, Marignier, Romain, additional, McGuigan, Chris, additional, Meira, Dália, additional, Merle, Harold, additional, Monteiro, Mário L.R., additional, Moodley, Anand, additional, Moura, Frederico, additional, Muñoz, Silvia, additional, Mustafa, Sharik, additional, Nakashima, Ichiro, additional, Noval, Susana, additional, Oehninger, Carlos, additional, Ogun, Olufunmilola, additional, Omoti, Afekhide, additional, Pandit, Lekha, additional, Paul, Friedemann, additional, Rebolleda, Gema, additional, Reddel, Stephen, additional, Rejdak, Konrad, additional, Rejdak, Robert, additional, Rodriguez-Morales, Alfonso, additional, Rougier, Marie-Bénédicte, additional, Sa, Maria Jose, additional, Sanchez-Dalmau, Bernardo, additional, Saylor, Deanna, additional, Shatriah, Ismail, additional, Siva, Aksel, additional, Stiebel-Kalish, Hadas, additional, Szatmary, Gabriella, additional, Ta, Linh, additional, Tenembaum, Sylvia, additional, Tran, Huy, additional, Trufanov, Yevgen, additional, VanPesch, Vincent, additional, Wang, An-Guor, additional, Wattjes, Mike P., additional, Willoughby, Ernie, additional, Zakaria, Magd, additional, Zvornicanin, Jasmin, additional, Balcer, Laura, additional, and Plant, Gordon T., additional

Published
2023
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22. Long-term Outcomes of MOGAD without Chronic Steroid-sparing Immunotherapy: a Multicenter Retrospective Cohort (S40.008)

Author

Tisavipat, Nanthaya, primary, Wilf-Yarkoni, Adi, additional, Flanagan, Eoin, additional, Redenbaugh, Vyanka, additional, Schwartzmann, Yoel, additional, Hellmann, Mark, additional, Tolkovsky, Assaf, additional, Stiebel-Kalish, Hadas, additional, Lotan, Itay, additional, Levy, Michael, additional, Salky, Rebecca, additional, Vaknin-Dembinsky, Adi, additional, Ganelin-Cohen, Esther, additional, Lopez, Alfonso, additional, Pittock, Sean, additional, and Chen, John, additional

Published
2023
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24. The Acute Optic Neuritis Network (ACON): Study protocol of a non-interventional prospective multicenter study on diagnosis and treatment of acute optic neuritis

Author

Asseyer, Susanna, primary, Asgari, Nasrin, additional, Bennett, Jeffrey, additional, Bialer, Omer, additional, Blanco, Yolanda, additional, Bosello, Francesca, additional, Camos-Carreras, Anna, additional, Carnero Contentti, Edgar, additional, Carta, Sara, additional, Chen, John, additional, Chien, Claudia, additional, Chomba, Mashina, additional, Dale, Russell C., additional, Dalmau, Josep, additional, Feldmann, Kristina, additional, Flanagan, Eoin P., additional, Froment Tilikete, Caroline, additional, Garcia-Alfonso, Carolina, additional, Havla, Joachim, additional, Hellmann, Mark, additional, Kim, Ho Jin, additional, Klyscz, Philipp, additional, Konietschke, Frank, additional, La Morgia, Chiara, additional, Lana-Peixoto, Marco, additional, Leite, Maria Isabel, additional, Levin, Netta, additional, Levy, Michael, additional, Llufriu, Sara, additional, Lopez, Pablo, additional, Lotan, Itay, additional, Lugaresi, Alessandra, additional, Marignier, Romain, additional, Mariotto, Sara, additional, Mollan, Susan P., additional, Ocampo, Cassandra, additional, Cosima Oertel, Frederike, additional, Olszewska, Maja, additional, Palace, Jacqueline, additional, Pandit, Lekha, additional, Peralta Uribe, José Luis, additional, Pittock, Sean, additional, Ramanathan, Sudarshini, additional, Rattanathamsakul, Natthapon, additional, Saiz, Albert, additional, Samadzadeh, Sara, additional, Sanchez-Dalmau, Bernardo, additional, Saylor, Deanna, additional, Scheel, Michael, additional, Schmitz-Hübsch, Tanja, additional, Shifa, Jemal, additional, Siritho, Sasitorn, additional, Sperber, Pia S., additional, Subramanian, Prem S., additional, Tiosano, Alon, additional, Vaknin-Dembinsky, Adi, additional, Mejia Vergara, Alvaro Jose, additional, Wilf-Yarkoni, Adi, additional, Zarco, Luis Alfonso, additional, Zimmermann, Hanna G., additional, Paul, Friedemann, additional, and Stiebel-Kalish, Hadas, additional

Published
2023
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25. sj-docx-1-msj-10.1177_13524585231184738 – Supplemental material for Intravenous immunoglobulin treatment for acute attacks in myelin oligodendrocyte glycoprotein antibody disease

Author

Lotan, Itay, Chen, John J, Hacohen, Yael, Abdel-Mannan, Omar, Mariotto, Sara, Huda, Saif, Gibbons, Emily, Wilf-Yarkoni, Adi, Hellmann, Mark A, Stiebel-Kalish, Hadas, Pittock, Sean J, Flanagan, Eoin P, Molazadeh, Negar, Anderson, Monique, Salky, Rebecca, Romanow, Gabriela, Schindler, Patrick, Duchow, Ankelien Solveig, Paul, Friedemann, and Levy, Michael

Subjects
Aged Health Care, Neurology and Neuromuscular Diseases, FOS: Clinical medicine
Abstract

Supplemental material, sj-docx-1-msj-10.1177_13524585231184738 for Intravenous immunoglobulin treatment for acute attacks in myelin oligodendrocyte glycoprotein antibody disease by Itay Lotan, John J Chen, Yael Hacohen, Omar Abdel-Mannan, Sara Mariotto, Saif Huda, Emily Gibbons, Adi Wilf-Yarkoni, Mark A Hellmann, Hadas Stiebel-Kalish, Sean J Pittock, Eoin P Flanagan, Negar Molazadeh, Monique Anderson, Rebecca Salky, Gabriela Romanow, Patrick Schindler, Ankelien Solveig Duchow, Friedemann Paul and Michael Levy in Multiple Sclerosis Journal

Published
2023
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26. Intravenous immunoglobulin treatment for acute attacks in myelin oligodendrocyte glycoprotein antibody disease

Author

Lotan, Itay, Chen, John J, Hacohen, Yael, Abdel-Mannan, Omar, Mariotto, Sara, Huda, Saif, Gibbons, Emily, Wilf-Yarkoni, Adi, Hellmann, Mark A, Stiebel-Kalish, Hadas, Pittock, Sean J, Flanagan, Eoin P, Molazadeh, Negar, Anderson, Monique, Salky, Rebecca, Romanow, Gabriela, Schindler, Patrick, Duchow, Ankelien Solveig, Paul, Friedemann, and Levy, Michael

Subjects
IVIG, safety, acute treatment, effectiveness, outcomes, MOGAD
Published
2023

27. A Consensus Statement on the Terminology for Automated Visual Field Abnormalities

Author

Kruger, Joshua M., primary, Almer, Zina, additional, Almog, Yehoshua, additional, Aloni, Eyal, additional, Bachar-Zipori, Anat, additional, Bialer, Omer, additional, Ben-Bassat Mizrachi, Iris, additional, Horowitz, Josepha, additional, Huna-Baron, Ruth, additional, Ivanir, Yair, additional, Jabaly-Habib, Haneen, additional, Klein, Ainat, additional, Krasnitz, Irena, additional, Leiba, Hana, additional, Maharshak, Idit, additional, Marcus, Mira, additional, Ostashinsky, Michal, additional, Paul, Michael, additional, Rappoport, Daniel, additional, Stiebel-Kalish, Hadas, additional, Rath, Eitan Z., additional, Tam, Guy, additional, Walter, Eyal, additional, and Johnson, Chris A., additional

Published
2022
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29. Association of Maintenance Intravenous Immunoglobulin With Prevention of Relapse in Adult Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease

Author

Chen, John J., primary, Huda, Saif, additional, Hacohen, Yael, additional, Levy, Michael, additional, Lotan, Itay, additional, Wilf-Yarkoni, Adi, additional, Stiebel-Kalish, Hadas, additional, Hellmann, Mark A., additional, Sotirchos, Elias S., additional, Henderson, Amanda D., additional, Pittock, Sean J., additional, Bhatti, M. Tariq, additional, Eggenberger, Eric R., additional, Di Nome, Marie, additional, Kim, Ho Jin, additional, Kim, Su-Hyun, additional, Saiz, Albert, additional, Paul, Friedemann, additional, Dale, Russell C., additional, Ramanathan, Sudarshini, additional, Palace, Jacqueline, additional, Camera, Valentina, additional, Leite, Maria Isabel, additional, Lam, Byron L., additional, Bennett, Jeffrey L., additional, Mariotto, Sara, additional, Hodge, Dave, additional, Audoin, Bertrand, additional, Maillart, Elisabeth, additional, Deschamps, Romain, additional, Pique, Julie, additional, Flanagan, Eoin P., additional, and Marignier, Romain, additional

Published
2022
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30. Obesity is associated with myelin oligodendrocyte glycoprotein antibody-associated disease in acute optic neuritis

Author

Stiebel-Kalish*, Hadas, primary, Rubarth, Kerstin, additional, Blum, Karni, additional, Tiosano, Alon, additional, Lotan, Itay, additional, Hellmann, Mark A., additional, Wilf-Yarkoni, Adi, additional, Bialer, Omer, additional, Flanagan, Eoin P., additional, Pittock, Sean J., additional, Bhatti, M. Tariq, additional, Schmitz-Hübsch, Tanja, additional, Friedemann, Paul, additional, Asseyer#, Susanna, additional, and Chen#, John J., additional

Published
2022
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31. Obesity is Associated With Myelin Oligodendrocyte Glycoprotein Antibody Associated Disease in Acute Optic Neuritis

Author

Stiebel-Kalish, Hadas, primary, Rubarth, Kerstin, additional, Blum, Karni, additional, Tiosano, Alon, additional, Lotan, Itay, additional, Hellmann, Mark A., additional, Wilf-Yarkoni, Adi, additional, Bialer, Omer, additional, Flanagan, Eoin P., additional, Pittock, Sean J., additional, Bhatti, M. Tariq, additional, Schmitz-Hübsch, Tanja, additional, Friedemann, Paul, additional, Asseyer, Susanna, additional, and Chen, John J., additional

Published
2022
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32. OCT retinal nerve fiber layer thickness differentiates acute optic neuritis from MOG antibody-associated disease and Multiple Sclerosis

Author

Chen, John J., primary, Sotirchos, Elias S., additional, Henderson, Amanda D., additional, Vasileiou, Eleni S., additional, Flanagan, Eoin P., additional, Bhatti, M. Tariq, additional, Jamali, Sepideh, additional, Eggenberger, Eric R., additional, Dinome, Marie, additional, Frohman, Larry P., additional, Arnold, Anthony C., additional, Bonelli, Laura, additional, Seleme, Nicolas, additional, Mejia-Vergara, Alvaro J., additional, Moss, Heather E., additional, Padungkiatsagul, Tanyatuth, additional, Stiebel-Kalish, Hadas, additional, Lotan, Itay, additional, Hellmann, Mark A., additional, Hodge, Dave, additional, Oertel, Frederike Cosima, additional, Paul, Friedemann, additional, Saidha, Shiv, additional, Calabresi, Peter A., additional, and Pittock, Sean J., additional

Published
2022
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34. Astrocytic outer retinal layer thinning is not a feature in AQP4-IgG seropositive neuromyelitis optica spectrum disorders

Author

Lu, Angelo, primary, Zimmermann, Hanna G, additional, Specovius, Svenja, additional, Motamedi, Seyedamirhosein, additional, Chien, Claudia, additional, Bereuter, Charlotte, additional, Lana-Peixoto, Marco A, additional, Fontenelle, Mariana Andrade, additional, Ashtari, Fereshteh, additional, Kafieh, Rahele, additional, Dehghani, Alireza, additional, Pourazizi, Mohsen, additional, Pandit, Lekha, additional, D'Cunha, Anitha, additional, Kim, Ho Jin, additional, Hyun, Jae-Won, additional, Jung, Su-Kyung, additional, Leocani, Letizia, additional, Pisa, Marco, additional, Radaelli, Marta, additional, Siritho, Sasitorn, additional, May, Eugene F, additional, Tongco, Caryl, additional, De Sèze, Jérôme, additional, Senger, Thomas, additional, Palace, Jacqueline, additional, Roca-Fernández, Adriana, additional, Leite, Maria Isabel, additional, Sharma, Srilakshmi M, additional, Stiebel-Kalish, Hadas, additional, Asgari, Nasrin, additional, Soelberg, Kerstin Kathrine, additional, Martinez-Lapiscina, Elena H, additional, Havla, Joachim, additional, Mao-Draayer, Yang, additional, Rimler, Zoe, additional, Reid, Allyson, additional, Marignier, Romain, additional, Cobo-Calvo, Alvaro, additional, Altintas, Ayse, additional, Tanriverdi, Uygur, additional, Yildirim, Rengin, additional, Aktas, Orhan, additional, Ringelstein, Marius, additional, Albrecht, Philipp, additional, Tavares, Ivan Maynart, additional, Bichuetti, Denis Bernardi, additional, Jacob, Anu, additional, Huda, Saif, additional, Soto de Castillo, Ibis, additional, Petzold, Axel, additional, Green, Ari J, additional, Yeaman, Michael R, additional, Smith, Terry J, additional, Cook, Lawrence, additional, Paul, Friedemann, additional, Brandt, Alexander U, additional, and Oertel, Frederike Cosima, additional

Published
2021
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35. Retinal Optical Coherence Tomography in Neuromyelitis Optica

Author

Oertel, Frederike Cosima, primary, Specovius, Svenja, additional, Zimmermann, Hanna G., additional, Chien, Claudia, additional, Motamedi, Seyedamirhosein, additional, Bereuter, Charlotte, additional, Cook, Lawrence, additional, Lana Peixoto, Marco Aurélio, additional, Fontanelle, Mariana Andrade, additional, Kim, Ho Jin, additional, Hyun, Jae-Won, additional, Palace, Jacqueline, additional, Roca-Fernandez, Adriana, additional, Leite, Maria Isabel, additional, Sharma, Srilakshmi, additional, Ashtari, Fereshteh, additional, Kafieh, Rahele, additional, Dehghani, Alireza, additional, Pourazizi, Mohsen, additional, Pandit, Lekha, additional, D'Cunha, Anitha, additional, Aktas, Orhan, additional, Ringelstein, Marius, additional, Albrecht, Philipp, additional, May, Eugene, additional, Tongco, Caryl, additional, Leocani, Letizia, additional, Pisa, Marco, additional, Radaelli, Marta, additional, Martinez-Lapiscina, Elena H., additional, Stiebel-Kalish, Hadas, additional, Siritho, Sasitorn, additional, de Seze, Jérome, additional, Senger, Thomas, additional, Havla, Joachim, additional, Marignier, Romain, additional, Calvo, Alvaro Cobo, additional, Bichuetti, Denis, additional, Tavares, Ivan Maynart, additional, Asgari, Nasrin, additional, Soelberg, Kerstin, additional, Altintas, Ayse, additional, Yildirim, Rengin, additional, Tanriverdi, Uygur, additional, Jacob, Anu, additional, Huda, Saif, additional, Rimler, Zoe, additional, Reid, Allyson, additional, Mao-Draayer, Yang, additional, Soto de Castillo, Ibis, additional, Petzold, Axel, additional, Green, Ari J., additional, Yeaman, Michael R., additional, Smith, Terry, additional, Brandt, Alexander U., additional, and Paul, Friedemann, additional

Published
2021
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39. Mild Phenotype of Wolfram Syndrome Associated With a Common Pathogenic Variant Is Predicted by a Structural Model of Wolframin

Author

Wilf-Yarkoni, Adi, primary, Shor, Oded, additional, Fellner, Avi, additional, Hellmann, Mark Andrew, additional, Pras, Elon, additional, Yonath, Hagit, additional, Shkedi-Rafid, Shiri, additional, Basel-Salmon, Lina, additional, Bazak, Lili, additional, Eliahou, Ruth, additional, Greenbaum, Lior, additional, Stiebel-Kalish, Hadas, additional, Benninger, Felix, additional, and Goldberg, Yael, additional

Published
2021
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40. Cohort profile: a collaborative multicentre study of retinal optical coherence tomography in 539 patients with neuromyelitis optica spectrum disorders (CROCTINO)

Author

Altıntaş, Ayşe (ORCID 0000-0002-8524-5087 & YÖK ID 11611), Specovius, Svenja; Zimmermann, Hanna G.; Oertel, Frederike Cosima; Chien, Claudia; Bereuter, Charlotte; Cook, Lawrence J.; Lana Peixoto, Marco Aurelio; Fontenelle, Mariana Andrade; Kim, Ho Jin; Hyun, Jae-Won; Jung, Su-Kyung; Palace, Jacqueline; Roca-Fernandez, Adriana; Diaz, Alejandro Rubio; Leite, Maria Isabel; Sharma, Srilakshmi M.; Ashtari, Fereshte; Kafieh, Rahele; Dehghani, Alireza; Pourazizi, Mohsen; Pandit, Lekha; Dcunha, Anitha; Aktas, Orhan; Ringelstein, Marius; Albrecht, Philipp; May, Eugene; Tongco, Caryl; Leocani, Letizia; Pisa, Marco; Radaelli, Marta; Martinez-Lapiscina, Elena H.; Stiebel-Kalish, Hadas; Hellmann, Mark; Lotan, Itay; Siritho, Sasitorn; de Seze, Jerome; Senger, Thomas; Havla, Joachim; Marignier, Romain; Tilikete, Caroline; Cobo Calvo, Alvaro; Bichuetti, Denis Bernardi; Tavares, Ivan Maynart; Asgari, Nasrin; Soelberg, Kerstin; Yıldırım, Rengin; Tanrıverdi, Uygur; Jacob, Anu; Huda, Saif; Rimler, Zoe; Reid, Allyson; Mao-Draayer, Yang; de Castillo, Ibis Soto; Yeaman, Michael R.; Smith, Terry J.; Brandt, Alexander U.; Paul, Friedemann; GJCF Int Clinical Consortium NMOSD, School of Medicine, Altıntaş, Ayşe (ORCID 0000-0002-8524-5087 & YÖK ID 11611), Specovius, Svenja; Zimmermann, Hanna G.; Oertel, Frederike Cosima; Chien, Claudia; Bereuter, Charlotte; Cook, Lawrence J.; Lana Peixoto, Marco Aurelio; Fontenelle, Mariana Andrade; Kim, Ho Jin; Hyun, Jae-Won; Jung, Su-Kyung; Palace, Jacqueline; Roca-Fernandez, Adriana; Diaz, Alejandro Rubio; Leite, Maria Isabel; Sharma, Srilakshmi M.; Ashtari, Fereshte; Kafieh, Rahele; Dehghani, Alireza; Pourazizi, Mohsen; Pandit, Lekha; Dcunha, Anitha; Aktas, Orhan; Ringelstein, Marius; Albrecht, Philipp; May, Eugene; Tongco, Caryl; Leocani, Letizia; Pisa, Marco; Radaelli, Marta; Martinez-Lapiscina, Elena H.; Stiebel-Kalish, Hadas; Hellmann, Mark; Lotan, Itay; Siritho, Sasitorn; de Seze, Jerome; Senger, Thomas; Havla, Joachim; Marignier, Romain; Tilikete, Caroline; Cobo Calvo, Alvaro; Bichuetti, Denis Bernardi; Tavares, Ivan Maynart; Asgari, Nasrin; Soelberg, Kerstin; Yıldırım, Rengin; Tanrıverdi, Uygur; Jacob, Anu; Huda, Saif; Rimler, Zoe; Reid, Allyson; Mao-Draayer, Yang; de Castillo, Ibis Soto; Yeaman, Michael R.; Smith, Terry J.; Brandt, Alexander U.; Paul, Friedemann; GJCF Int Clinical Consortium NMOSD, and School of Medicine

Abstract

Purpose: optical coherence tomography (OCT) captures retinal damage in neuromyelitis optica spectrum disorders (NMOSD). Previous studies investigating OCT in NMOSD have been limited by the rareness and heterogeneity of the disease. The goal of this study was to establish an image repository platform, which will facilitate neuroimaging studies in NMOSD. Here we summarise the profile of the Collaborative OCT in NMOSD repository as the initial effort in establishing this platform. This repository should prove invaluable for studies using OCT to investigate NMOSD. Participants: the current cohort includes data from 539 patients with NMOSD and 114 healthy controls. These were collected at 22 participating centres from North and South America, Asia and Europe. The dataset consists of demographic details, diagnosis, antibody status, clinical disability, visual function, history of optic neuritis and other NMOSD defining attacks, and OCT source data from three different OCT devices. Findings to date: the cohort informs similar demographic and clinical characteristics as those of previously published NMOSD cohorts. The image repository platform and centre network continue to be available for future prospective neuroimaging studies in NMOSD. For the conduct of the study, we have refined OCT image quality criteria and developed a cross-device intraretinal segmentation pipeline. Future plans: we are pursuing several scientific projects based on the repository, such as analysing retinal layer thickness measurements, in this cohort in an attempt to identify differences between distinct disease phenotypes, demographics and ethnicities. The dataset will be available for further projects to interested, qualified parties, such as those using specialised image analysis or artificial intelligence applications., Guthy Jackson Charitable Foundation

Published
2020

43. Application of diagnostic criteria for optic neuritis – Authors' reply

Author

Fraser, Clare, Abegg, Mathias, Alroughani, Raed, Alshowaeir, Daniah, Alvarenga, Regina, Andris, Cécile, Asgari, Nasrin, Barnett, Yael, Battistella, Roberto, Behbehani, Raed, Berger, Thomas, Bikbov, Mukharram M., Biotti, Damien, Biousse, Valerie, Boschi, Antonella, Brazdil, Milan, Brezhnev, Andrei, Calabresi, Peter, Cordonnier, Monique, Costello, Fiona, Cruz, Franz Marie, Cunha, Leonardo Provetti, Daoudi, Smail, Deschamps, Romain, DeSeze, Jerome, Diem, Ricarda, Etemadifar, Masoud, Flores-Rivera, Jose, Fonseca, Pedro, Frederiksen, Jette, Frohman, Elliot, Frohman, Teresa, FromentTilikete, Caroline, Fujihara, Kazuo, Gálvez, Alberto, Gouider, Riadh, Gracia, Fernando, Grigoriadis, Nikolaos, Guajardo, José Manuel, Habek, Mario, Hawlina, Marko, Hernández-Martínez de Lapiscina, Elena, Hooker, Juzar, Hor, Jyh Yung, Howlett, William, Huang-Link, Yumin, Idrissova, Zhannat, Illes, Zsolt, Jancic, Jasna, Jindahra, Panitha, Karussis, Dimitrios, Kerty, Emilia, Kim, Ho Jin, Lagrèze, Wolf, Leocani, Letizia, Levin, Netta, Liskova, Petra, Maiga, Youssoufa, Marignier, Romain, McGuigan, Chris, Meira, Dália, Merle, Harold, Monteiro, Mário L.R., Moodley, Anand, Moura, Frederico, Muñoz, Silvia, Mustafa, Sharik, Nakashima, Ichiro, Noval, Susana, Oehninger, Carlos, Ogun, Olufunmilola, Omoti, Afekhide, Pandit, Lekha, Paul, Friedemann, Rebolleda, Gema, Reddel, Stephen, Rejdak, Konrad, Rejdak, Robert, Rodriguez-Morales, Alfonso, Rougier, Marie-Bénédicte, Sa, Maria Jose, Sanchez-Dalmau, Bernardo, Saylor, Deanna, Shatriah, Ismail, Siva, Aksel, Stiebel-Kalish, Hadas, Szatmary, Gabriella, Ta, Linh, Tenembaum, Sylvia, Tran, Huy, Trufanov, Yevgen, VanPesch, Vincent, Wang, An-Guor, Wattjes, Mike P., Willoughby, Ernie, Zakaria, Magd, Zvornicanin, Jasmin, Balcer, Laura, Plant, Gordon T., Petzold, Axel, and Liu, Yaou

Published
2023
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50. A Single Low-Dose of Methylphenidate Improves Abnormal Visual Field Testing.

Author

Sternfeld, Amir, Bialer, Omer Y., Keidar, Dotan, Megiddo, Elinor, Budnik, Ivan, Stiebel-Kalish, Hadas, and Livnat, Tami

Subjects
VISUAL fields, METHYLPHENIDATE, STANDARD deviations, ADULTS, EYE examination
Abstract

To evaluate the effect of methylphenidate on visual field testing in healthy adults with abnormal visual field results. This prospective, randomized, controlled interventional clinical trial comprised all patients who had abnormal visual field test results and normal eye examination and ophthalmic history. Eligible patients were randomly assigned to either the study group or the control group. All patients repeated their visual field testing. Study group patients received a single dose of 10 mg methylphenidate prior to that. The main outcome measures were the percent difference in mean deviation and pattern standard deviation between the second and first visual fields. The methylphenidate group had greater improvement in all parameters. Mean deviation improved by median 68% (IQR 19%–78%) in the methylphenidate group vs. 27% [−5% to 55%] in the controls. However, this was not statistically significant (p =.83). Pattern standard deviation improved by median 49% (22%–59%) vs. 7% [−9% to 45%], respectively (p =.012). The visual fields were also reviewed by 3 masked experienced ophthalmologists. They indicated that the second visual field improved in 76.2% of the methylphenidate group vs. 48.5% of the controls (p =.04). A normal repeat visual field occurred in 57.7% vs. 21.2%, respectively. A subgroup analysis of patients with prior experience in visual field testing yielded an even more striking improvement in the methylphenidate group vs. controls. A single low dose of methylphenidate can improve visual field testing in subjects without ocular pathology, and even more in those with prior experience in perimetry. [ABSTRACT FROM AUTHOR]

Published
2021
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