Author: "Stilo, Simona A" - Searchworks@Jio Institute Digital Library Search Results

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1. Causes and Outcome of Psychosis

Author: Casetta, Cecilia, primary, Kępińska, Adrianna P., additional, Stilo, Simona A., additional, and Murray, Robin M., additional
Published: 2024
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2. The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study

Author: Sideli, Lucia, Aas, Monica, Quattrone, Diego, La Barbera, Daniele, La Cascia, Caterina, Ferraro, Laura, Alameda, Luis, Velthorst, Eva, Trotta, Giulia, Tripoli, Giada, Schimmenti, Adriano, Fontana, Andrea, Gayer-Anderson, Charlotte, Stilo, Simona, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, Berardi, Domenico, D’Andrea, Giuseppe, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, Sanjuán, Julio, Santos, Jose Luis, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Jongsma, Hannah E., Jones, Peter B., Kirkbride, James B., Llorca, Pierre-Michel, Tortelli, Andrea, Pignon, Baptiste, de Haan, Lieuwe, Selten, Jean-Paul, Van Os, Jim, Rutten, Bart P., Bentall, Richard, Di Forti, Marta, Murray, Robin M., Morgan, Craig, and Fisher, Helen L.
Published: 2023
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3. Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis—findings from the EU-GEI study

Author: Alameda, Luis, Liu, Zhonghua, Sham, Pak C., Aas, Monica, Trotta, Giulia, Rodriguez, Victoria, Di Forti, Marta, Stilo, Simona A., Kandaswamy, Radhika, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, de Haan, Lieuwe, Del-Ben, Cristina Marta, Gayer-Anderson, Charlotte, Sideli, Lucia, Jones, Peter B., Jongsma, Hannah E., Kirkbride, James B., La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre-Michel, Menezes, Paulo Rossi, van Os, Jim, Quattrone, Diego, Rutten, Bart P., Santos, Jose Luis, Sanjuán, Julio, Selten, Jean-Paul, Szöke, Andrei, Tarricone, Ilaria, Tortelli, Andrea, Velthorst, Eva, Morgan, Craig, Dempster, Emma, Hannon, Eilis, Burrage, Joe, Dwir, Daniella, Arumuham, Atheeshaan, Mill, Jonathan, Murray, Robin M., and Wong, Chloe C. Y.
Published: 2023
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4. The impact of adverse social experiences in a sample of first episode psychosis patients

Author: Stilo, Simona Ausilia, Morgan, Craig, and Murray, Robin MacGregor
Subjects: 362.19689
Abstract: The robust evidence that the incidence of psychosis is elevated in many migrant and minority ethnic population, especially the black population in the UK, has led to a resurgence of interest in the potential role of socio-environmental factors. A growing body of evidence suggests that experiences of social adversity can increase risk of psychosis, particularly in the presence of other known risk factors (e.g. genetic risk). The aims of this thesis are to investigate the relationship between psychosis and a number of current and long-term indicators of childhood and adulthood social adversity in patients suffering their first episode of psychosis (n = 507) and in a control sample (425). Detailed data on social adversity were collected as part of the GAP and EU-GEI studies. Across all the domains considered, cases were more likely to report social adversity than were controls. Social adversity, especially in the case of cumulative exposure, was associated with up to a 9 fold increased risk of psychosis, independent of potential confounders. Greater number of indicators present and longer exposure result in progressively greater risk (linear relationship). Contrary to my hypothesis, no evidence was found that social adversity was more common in Black and other minority groups compared to White British subjects. However, going beyond the study of each risk factor individually, I found evidence that childhood adversity and adulthood adversity combined synergistically to increase the odds of psychosis, and social adversity in adulthood, combine with cannabis use, conferring a greater risk than would be expected if each worked through a separate causal pathway. Although the results were not significant, there was a trend towards an additive interaction between adversity in adulthood and psychosis family history.
Published: 2015

5. The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study

Author: Amoretti, Silvia, Arrojo, Manuel, Baudin, Grégoire, Beards, Stephanie, Bernardo, Miquel, Bobes, Julio, Bonetto, Chiara, Cabrera, Bibiana, Carracedo, Angel, Charpeaud, Thomas, Costas, Javier, Cristofalo, Doriana, Cuadrado, Pedro, Díaz-Caneja, Covadonga M, Ferchiou, Aziz, Franke, Nathalie, Frijda, Flora, García Bernardo, Enrique, Garcia-Portilla, Paz, González, Emiliano, Hubbard, Kathryn, Jamain, Stéphane, Jiménez-López, Estela, Leboyer, Marion, López Montoya, Gonzalo, Lorente-Rovira, Esther, Marcelino Loureiro, Camila, Marrazzo, Giovanna, Martínez, Covadonga, Matteis, Mario, Messchaart, Elles, Moltó, Ma Dolores, Nacher, Juan, Olmeda, Ma Soledad, Parellada, Mara, González Peñas, Javier, Pignon, Baptiste, Rapado, Marta, Richard, Jean-Romain, Rodríguez Solano, José Juan, Roldán Díaz, Laura, Ruggeri, Mirella, Sáiz, Pilar A., Sánchez, Emilio, Sanjuán, Julio, Sartorio, Crocettarachele, Schürhoff, Franck, Seminerio, Fabio, Shuhama, Rosana, Sideli, Lucia, Stilo, Simona A, Termorshuizen, Fabian, Tosato, Sarah, Tronche, Anne-Marie, van Dam, Daniella, van der Ven, Elsje, Di Forti, Marta, Quattrone, Diego, Freeman, Tom P, Tripoli, Giada, Gayer-Anderson, Charlotte, Quigley, Harriet, Rodriguez, Victoria, Jongsma, Hannah E, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Berardi, Domenico, Szöke, Andrei, Arango, Celso, Tortelli, Andrea, Velthorst, Eva, Bernardo, Miguel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B, Kirkbride, James B, Rutten, Bart PF, de Haan, Lieuwe, Sham, Pak C, van Os, Jim, Lewis, Cathryn M, Lynskey, Michael, Morgan, Craig, and Murray, Robin M
Published: 2019
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6. Variation of subclinical psychosis across 16 sites in Europe and Brazil: findings from the multi-national EU-GEI study

Author: D'Andrea, Giuseppe, primary, Quattrone, Diego, additional, Malone, Kathryn, additional, Tripoli, Giada, additional, Trotta, Giulia, additional, Spinazzola, Edoardo, additional, Gayer-Anderson, Charlotte, additional, Jongsma, Hannah E, additional, Sideli, Lucia, additional, Stilo, Simona A, additional, La Cascia, Caterina, additional, Ferraro, Laura, additional, Lasalvia, Antonio, additional, Tosato, Sarah, additional, Tortelli, Andrea, additional, Velthorst, Eva, additional, de Haan, Lieuwe, additional, Llorca, Pierre-Michel, additional, Rossi Menezes, Paulo, additional, Santos, Jose Luis, additional, Arrojo, Manuel, additional, Bobes, Julio, additional, Sanjuán, Julio, additional, Bernardo, Miguel, additional, Arango, Celso, additional, Kirkbride, James B, additional, Jones, Peter B, additional, Rutten, Bart P, additional, Van Os, Jim, additional, Selten, Jean-Paul, additional, Vassos, Evangelos, additional, Schürhoff, Franck, additional, Szöke, Andrei, additional, Pignon, Baptiste, additional, O'Donovan, Michael, additional, Richards, Alexander, additional, Morgan, Craig, additional, Di Forti, Marta, additional, Tarricone, Ilaria, additional, and Murray, Robin M, additional
Published: 2024
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7. Different types of childhood adversity and 5-year outcomes in a longitudinal cohort of first-episode psychosis patients

Author: Ajnakina, Olesya, Trotta, Antonella, Forti, Marta Di, Stilo, Simona A., Kolliakou, Anna, Gardner-Sood, Poonam, Lopez-Morinigo, Javier, Gaughran, Fiona, David, Anthony S., Dazzan, Paola, Pariante, Carmine, Mondelli, Valeria, Murray, Robin M., and Fisher, Helen L.
Published: 2018
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8. Utilising symptom dimensions with diagnostic categories improves prediction of time to first remission in first-episode psychosis

Author: Ajnakina, Olesya, Lally, John, Di Forti, Marta, Stilo, Simona A., Kolliakou, Anna, Gardner-Sood, Poonam, Dazzan, Paola, Pariante, Carmine, Reis Marques, Tiago, Mondelli, Valeria, MacCabe, James, Gaughran, Fiona, David, Anthony S., Stamate, Daniel, Murray, Robin M., and Fisher, Helen L.
Published: 2018
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9. Non-Genetic Factors in Schizophrenia

Author: Stilo, Simona A. and Murray, Robin M.
Published: 2019
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10. Development and Validation of Predictive Model for a Diagnosis of First Episode Psychosis Using the Multinational EU-GEI Case-control Study and Modern Statistical Learning Methods

Author: Hersenen-Medisch 1, Brain, Ajnakina, Olesya, Fadilah, Ihsan, Quattrone, Diego, Arango, Celso, Berardi, Domenico, Bernardo, Miguel, Bobes, Julio, De Haan, Lieuwe, Del-Ben, Cristina Marta, Gayer-Anderson, Charlotte, Stilo, Simona, Jongsma, Hannah E., Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre Michel, Menezes, Paulo Rossi, Rutten, Bart P., Santos, Jose Luis, Sanjuán, Julio, Selten, Jean Paul, Szöke, Andrei, Tarricone, Ilaria, D'Andrea, Giuseppe, Tortelli, Andrea, Velthorst, Eva, Jones, Peter B., Romero, Manuel Arrojo, La Cascia, Caterina, Kirkbride, James B., Van Os, Jim, O'Donovan, Michael, Morgan, Craig, Di Forti, Marta, Murray, Robin M., Hubbard, Kathryn, Stahl, Daniel, Hersenen-Medisch 1, Brain, Ajnakina, Olesya, Fadilah, Ihsan, Quattrone, Diego, Arango, Celso, Berardi, Domenico, Bernardo, Miguel, Bobes, Julio, De Haan, Lieuwe, Del-Ben, Cristina Marta, Gayer-Anderson, Charlotte, Stilo, Simona, Jongsma, Hannah E., Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre Michel, Menezes, Paulo Rossi, Rutten, Bart P., Santos, Jose Luis, Sanjuán, Julio, Selten, Jean Paul, Szöke, Andrei, Tarricone, Ilaria, D'Andrea, Giuseppe, Tortelli, Andrea, Velthorst, Eva, Jones, Peter B., Romero, Manuel Arrojo, La Cascia, Caterina, Kirkbride, James B., Van Os, Jim, O'Donovan, Michael, Morgan, Craig, Di Forti, Marta, Murray, Robin M., Hubbard, Kathryn, and Stahl, Daniel
Published: 2023

11. Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis-findings from the EU-GEI study

Author: Hersenen-Medisch 1, Brain, Alameda, Luis, Liu, Zhonghua, Sham, Pak C, Aas, Monica, Trotta, Giulia, Rodriguez, Victoria, Di Forti, Marta, Stilo, Simona A, Kandaswamy, Radhika, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, de Haan, Lieuwe, Del-Ben, Cristina Marta, Gayer-Anderson, Charlotte, Sideli, Lucia, Jones, Peter B, Jongsma, Hannah E, Kirkbride, James B, La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre-Michel, Menezes, Paulo Rossi, van Os, Jim, Quattrone, Diego, Rutten, Bart P, Santos, Jose Luis, Sanjuán, Julio, Selten, Jean-Paul, Szöke, Andrei, Tarricone, Ilaria, Tortelli, Andrea, Velthorst, Eva, Morgan, Craig, Dempster, Emma, Hannon, Eilis, Burrage, Joe, Dwir, Daniella, Arumuham, Atheeshaan, Mill, Jonathan, Murray, Robin M, Wong, Chloe C Y, Hersenen-Medisch 1, Brain, Alameda, Luis, Liu, Zhonghua, Sham, Pak C, Aas, Monica, Trotta, Giulia, Rodriguez, Victoria, Di Forti, Marta, Stilo, Simona A, Kandaswamy, Radhika, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, de Haan, Lieuwe, Del-Ben, Cristina Marta, Gayer-Anderson, Charlotte, Sideli, Lucia, Jones, Peter B, Jongsma, Hannah E, Kirkbride, James B, La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre-Michel, Menezes, Paulo Rossi, van Os, Jim, Quattrone, Diego, Rutten, Bart P, Santos, Jose Luis, Sanjuán, Julio, Selten, Jean-Paul, Szöke, Andrei, Tarricone, Ilaria, Tortelli, Andrea, Velthorst, Eva, Morgan, Craig, Dempster, Emma, Hannon, Eilis, Burrage, Joe, Dwir, Daniella, Arumuham, Atheeshaan, Mill, Jonathan, Murray, Robin M, and Wong, Chloe C Y
Published: 2023

12. Child maltreatment, migration and risk of first-episode psychosis: results from the multinational EU-GEI study

Author: Hersenen-Medisch 1, Brain, D'Andrea, Giuseppe, Lal, Jatin, Tosato, Sarah, Gayer-Anderson, Charlotte, Jongsma, Hannah E, Stilo, Simona A, van der Ven, Els, Quattrone, Diego, Velthorst, Eva, Berardi, Domenico, Rossi Menezes, Paulo, Arango, Celso, Parellada, Mara, Lasalvia, Antonio, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Sideli, Lucia, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Tripoli, Giada, Llorca, Pierre-Michel, de Haan, Lieuwe, Selten, Jean-Paul, Tortelli, Andrea, Szöke, Andrei, Muratori, Roberto, Rutten, Bart P, van Os, Jim, Jones, Peter B, Kirkbride, James B, Murray, Robin M, di Forti, Marta, Tarricone, Ilaria, Morgan, Craig, Hersenen-Medisch 1, Brain, D'Andrea, Giuseppe, Lal, Jatin, Tosato, Sarah, Gayer-Anderson, Charlotte, Jongsma, Hannah E, Stilo, Simona A, van der Ven, Els, Quattrone, Diego, Velthorst, Eva, Berardi, Domenico, Rossi Menezes, Paulo, Arango, Celso, Parellada, Mara, Lasalvia, Antonio, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Sideli, Lucia, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Tripoli, Giada, Llorca, Pierre-Michel, de Haan, Lieuwe, Selten, Jean-Paul, Tortelli, Andrea, Szöke, Andrei, Muratori, Roberto, Rutten, Bart P, van Os, Jim, Jones, Peter B, Kirkbride, James B, Murray, Robin M, di Forti, Marta, Tarricone, Ilaria, and Morgan, Craig
Published: 2023

13. Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study

Author: Hersenen-Medisch 1, Brain, Rodriguez, Victoria, Alameda, Luis, Quattrone, Diego, Tripoli, Giada, Gayer-Anderson, Charlotte, Spinazzola, Edoardo, Trotta, Giulia, Jongsma, Hannah E, Stilo, Simona, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, Bonora, Elena, Jamain, Stéphane, Selten, Jean-Paul, Velthorst, Eva, de Haan, Lieuwe, Llorca, Pierre-Michel, Arrojo, Manuel, Bobes, Julio, Bernardo, Miguel, Arango, Celso, Kirkbride, James, Jones, Peter B, Rutten, Bart P, Richards, Alexander, Sham, Pak C, O'Donovan, Michael, Van Os, Jim, Morgan, Craig, Di Forti, Marta, Murray, Robin M, Vassos, Evangelos, Hersenen-Medisch 1, Brain, Rodriguez, Victoria, Alameda, Luis, Quattrone, Diego, Tripoli, Giada, Gayer-Anderson, Charlotte, Spinazzola, Edoardo, Trotta, Giulia, Jongsma, Hannah E, Stilo, Simona, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, Bonora, Elena, Jamain, Stéphane, Selten, Jean-Paul, Velthorst, Eva, de Haan, Lieuwe, Llorca, Pierre-Michel, Arrojo, Manuel, Bobes, Julio, Bernardo, Miguel, Arango, Celso, Kirkbride, James, Jones, Peter B, Rutten, Bart P, Richards, Alexander, Sham, Pak C, O'Donovan, Michael, Van Os, Jim, Morgan, Craig, Di Forti, Marta, Murray, Robin M, and Vassos, Evangelos
Published: 2023

14. The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study

Author: European Commission, Sao Paulo Research Foundation, Netherlands Organization for Scientific Research, Economic and Social Research Council (UK), Kings College London, Medical Research Council (UK), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Comunidad de Madrid, National Institute of Mental Health (US), Fundación Familia Alonso, Fundación Alicia Koplowitz, Sideli, Lucia, Aas, Monica, Quattrone, Diego, La Barbera, Daniele, La Cascia, Caterina, Ferraro, Laura, Alameda, Luis, Velthorst, Eva, Trotta, Giulia, Tripoli, Giada, Schimmenti, Adriano, Fontana, Andrea, Gayer-Anderson, Charlotte, Stilo, Simona, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, Berardi, Domenico, D’Andrea, Giuseppe, EU-GEI WP2 Group, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, Sanjuán, Julio, Santos, José Luis, Rossi Menezes, Paulo, Del-Ben, Cristina Marta, Jongsma, Hannah E., Jones, Peter B., Kirkbride, James B., Llorca, Pierre-Michel, Tortelli, Andrea, Pignon, Baptiste, Haan, Lieuwe de, Selten, Jean-Paul, Os, Jim van, Rutten, Bart P. F., Bentall, Richard, Di Forti, Marta, Murray, Robin M., Morgan, Craig, Fisher, Helen L., European Commission, Sao Paulo Research Foundation, Netherlands Organization for Scientific Research, Economic and Social Research Council (UK), Kings College London, Medical Research Council (UK), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Comunidad de Madrid, National Institute of Mental Health (US), Fundación Familia Alonso, Fundación Alicia Koplowitz, Sideli, Lucia, Aas, Monica, Quattrone, Diego, La Barbera, Daniele, La Cascia, Caterina, Ferraro, Laura, Alameda, Luis, Velthorst, Eva, Trotta, Giulia, Tripoli, Giada, Schimmenti, Adriano, Fontana, Andrea, Gayer-Anderson, Charlotte, Stilo, Simona, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, Berardi, Domenico, D’Andrea, Giuseppe, EU-GEI WP2 Group, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Bobes, Julio, Sanjuán, Julio, Santos, José Luis, Rossi Menezes, Paulo, Del-Ben, Cristina Marta, Jongsma, Hannah E., Jones, Peter B., Kirkbride, James B., Llorca, Pierre-Michel, Tortelli, Andrea, Pignon, Baptiste, Haan, Lieuwe de, Selten, Jean-Paul, Os, Jim van, Rutten, Bart P. F., Bentall, Richard, Di Forti, Marta, Murray, Robin M., Morgan, Craig, and Fisher, Helen L.
Abstract: This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.
Published: 2023

15. Proportion of patients in south London with first-episode psychosis attributable to use of high potency cannabis: a case-control study

Author: Di Forti, Marta, Marconi, Arianna, Carra, Elena, Fraietta, Sara, Trotta, Antonella, Bonomo, Matteo, Bianconi, Francesca, Gardner-Sood, Poonam, O'Connor, Jennifer, Russo, Manuela, Stilo, Simona A, Marques, Tiago Reis, Mondelli, Valeria, Dazzan, Paola, Pariante, Carmine, David, Anthony S, Gaughran, Fiona, Atakan, Zerrin, Iyegbe, Conrad, Powell, John, Morgan, Craig, Lynskey, Michael, and Murray, Robin M
Published: 2015
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16. The association between reasons for first using cannabis, later pattern of use, and risk of first-episode psychosis: the EU-GEI case-control study

Author: Spinazzola, Edoardo, Quattrone, Diego, Rodriguez, Victoria, Trotta, Giulia, Alameda, Luis, Tripoli, Giada, Gayer-Anderson, Charlotte, Freeman, Tom P, Johnson, Emma C, Jongsma, Hannah E, Stilo, Simona, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, D'Andrea, Giuseppe, Galatolo, Michela, Tortelli, Andrea, Tagliabue, Ilaria, Turco, Marco, Pompili, Maurizio, Selten, Jean-Paul, de Haan, Lieuwe, Rossi Menezes, Paulo, Del Ben, Cristina M, Santos, Jose Luis, Arrojo, Manuel, Bobes, Julio, Sanjuán, Julio, Bernardo, Miguel, Arango, Celso, Kirkbride, James B, Jones, Peter B, O'Donovan, Michael, Rutten, Bart P, Van Os, Jim, Morgan, Craig, Sham, Pak C, Austin-Zimmerman, Isabelle, Zhikun, Li, Vassos, Evangelos, Murray, Robin M, and Di Forti, Marta
Subjects: psychotic disorders, path analysis, Cannabis use
Published: 2023

17. Post-migration trajectories and psychopathological vulnerability

Author: Tarricone, I., primary, Tarricone, Ilaria, additional, D’Andrea, Giuseppe, additional, Jongsma, Hannah E, additional, Tosato, Sarah, additional, Gayer-Anderson, Charlotte, additional, Stilo, Simona A., additional, Suprani, Federico, additional, Iyegbe, Conrad, additional, van der Ven, Els, additional, Quattrone, Diego, additional, di Forti, Marta, additional, Velthorst, Eva, additional, Menezes, Paulo Rossi, additional, Arango, Celso, additional, and Parel, Mara, additional
Published: 2023
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18. Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case–control study.

Author: Trotta, Giulia, Rodriguez, Victoria, Quattrone, Diego, Spinazzola, Edoardo, Tripoli, Giada, Gayer-Anderson, Charlotte, Freeman, Tom P, Jongsma, Hannah E, Sideli, Lucia, Aas, Monica, Stilo, Simona A, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, D'Andrea, Giuseppe, Tortelli, Andrea, and Schürhoff, Franck
Subjects: SUBSTANCE abuse prevention, ADVERSE childhood experiences, CANNABIS (Genus), SUBSTANCE abuse, PSYCHOSES, CASE-control method, QUESTIONNAIRES, RESEARCH funding, PSYCHOTHERAPY
Abstract: Background: Childhood adversity and cannabis use are considered independent risk factors for psychosis, but whether different patterns of cannabis use may be acting as mediator between adversity and psychotic disorders has not yet been explored. The aim of this study is to examine whether cannabis use mediates the relationship between childhood adversity and psychosis. Methods: Data were utilised on 881 first-episode psychosis patients and 1231 controls from the European network of national schizophrenia networks studying Gene–Environment Interactions (EU-GEI) study. Detailed history of cannabis use was collected with the Cannabis Experience Questionnaire. The Childhood Experience of Care and Abuse Questionnaire was used to assess exposure to household discord, sexual, physical or emotional abuse and bullying in two periods: early (0–11 years), and late (12–17 years). A path decomposition method was used to analyse whether the association between childhood adversity and psychosis was mediated by (1) lifetime cannabis use, (2) cannabis potency and (3) frequency of use. Results: The association between household discord and psychosis was partially mediated by lifetime use of cannabis (indirect effect coef. 0.078, s.e. 0.022, 17%), its potency (indirect effect coef. 0.059, s.e. 0.018, 14%) and by frequency (indirect effect coef. 0.117, s.e. 0.038, 29%). Similar findings were obtained when analyses were restricted to early exposure to household discord. Conclusions: Harmful patterns of cannabis use mediated the association between specific childhood adversities, like household discord, with later psychosis. Children exposed to particularly challenging environments in their household could benefit from psychosocial interventions aimed at preventing cannabis misuse. [ABSTRACT FROM AUTHOR]
Published: 2023
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19. Child maltreatment, migration and risk of first-episode psychosis: results from the multinational EU-GEI study.

Author: D'Andrea, Giuseppe, Lal, Jatin, Tosato, Sarah, Gayer-Anderson, Charlotte, Jongsma, Hannah E., Stilo, Simona A., van der Ven, Els, Quattrone, Diego, Velthorst, Eva, Berardi, Domenico, Rossi Menezes, Paulo, Arango, Celso, Parellada, Mara, Lasalvia, Antonio, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Sideli, Lucia, Bobes, Julio, and Bernardo, Miguel
Subjects: POPULATION, CHILD abuse, PSYCHOSES, PSYCHOLOGICAL vulnerability, MIGRANT labor, RISK assessment, PSYCHOSOCIAL factors, CHI-squared test, QUESTIONNAIRES, RESEARCH funding, LOGISTIC regression analysis
Abstract: Background: Child maltreatment (CM) and migrant status are independently associated with psychosis. We examined prevalence of CM by migrant status and tested whether migrant status moderated the association between CM and first-episode psychosis (FEP). We further explored whether differences in CM exposure contributed to variations in the incidence rates of FEP by migrant status. Methods: We included FEP patients aged 18–64 years in 14 European sites and recruited controls representative of the local populations. Migrant status was operationalized according to generation (first/further) and region of origin (Western/non-Western countries). The reference population was composed by individuals of host country's ethnicity. CM was assessed with Childhood Trauma Questionnaire. Prevalence ratios of CM were estimated using Poisson regression. We examined the moderation effect of migrant status on the odds of FEP by CM fitting adjusted logistic regressions with interaction terms. Finally, we calculated the population attributable fractions (PAFs) for CM by migrant status. Results: We examined 849 FEP cases and 1142 controls. CM prevalence was higher among migrants, their descendants and migrants of non-Western heritage. Migrant status, classified by generation (likelihood test ratio:χ2 = 11.3, p = 0.004) or by region of origin (likelihood test ratio:χ2 = 11.4, p = 0.003), attenuated the association between CM and FEP. PAFs for CM were higher among all migrant groups compared with the reference populations. Conclusions: The higher exposure to CM, despite a smaller effect on the odds of FEP, accounted for a greater proportion of incident FEP cases among migrants. Policies aimed at reducing CM should consider the increased vulnerability of specific subpopulations. [ABSTRACT FROM AUTHOR]
Published: 2023
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20. Methylomic signature of current cannabis use in two first-episode psychosis cohorts

Author: Dempster, Emma L., Wong, Chloe C. Y., Burrage, Joe, Hannon, Eilis, Quattrone, Diego, Trotta, Giulia, Rodriguez, Victoria, Alameda, Luis, Spinazzola, Edoardo, Tripoli, Giada, Austin-Zimmerman, Isabelle, Li, Zhikun, Gayer-Anderson, Charlotte, Freeman, Tom P., Johnson, Emma C., Jongsma, Hannah E., Stilo, Simona, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, D’Andrea, Giuseppe, Galatolo, Michela, Tortelli, Andrea, Pompili, Maurizio, Selten, Jean-Paul, de Haan, Lieuwe, Menezes, Paulo Rossi, Del Ben, Cristina M., Santos, Jose Luis, Arrojo, Manuel, Bobes, Julio, Sanjuán, Julio, Bernardo, Miguel, Arango, Celso, Jones, Peter B., Breen, Gerome, Mondelli, Valeria, Dazzan, Paola, Iyegbe, Conrad, Vassos, Evangelos, Morgan, Craig, Mukherjee, Diptendu, van Os, Jim, Rutten, Bart, O’Donovan, Michael C., Sham, Pak, Mill, Jonathan, Murray, Robin, and Di Forti, Marta
Abstract: The rising prevalence and legalisation of cannabis worldwide have underscored the need for a comprehensive understanding of its biological impact, particularly on mental health. Epigenetic mechanisms, specifically DNA methylation, have gained increasing recognition as vital factors in the interplay between risk factors and mental health. This study aimed to explore the effects of current cannabis use and high-potency cannabis on DNA methylation in two independent cohorts of individuals experiencing first-episode psychosis (FEP) compared to control subjects. The combined sample consisted of 682 participants (188 current cannabis users and 494 never users). DNA methylation profiles were generated on blood-derived DNA samples using the Illumina DNA methylation array platform. A meta-analysis across cohorts identified one CpG site (cg11669285) in the CAVIN1gene that showed differential methylation with current cannabis use, surpassing the array-wide significance threshold, and independent of the tobacco-related epigenetic signature. Furthermore, a CpG site localised in the MCUgene (cg11669285) achieved array-wide significance in an analysis of the effect of high-potency (THC = > 10%) current cannabis use. Pathway and regional analyses identified cannabis-related epigenetic variation proximal to genes linked to immune and mitochondrial function, both of which are known to be influenced by cannabinoids. Interestingly, a model including an interaction term between cannabis use and FEP status identified two sites that were significantly associated with current cannabis use with a nominally significant interaction suggesting that FEP status might moderate how cannabis use affects DNA methylation. Overall, these findings contribute to our understanding of the epigenetic impact of current cannabis use and highlight potential molecular pathways affected by cannabis exposure.
Published: 2024
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21. Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis – findings from the EU-GEI study

Author: Luis Alameda, Zhonghua Liu, Pak Sham, AAS Monica, Trotta Giulia, Rodriguez Victoria, Marta di Forti, Stilo Simona, Kandaswamy Radhika, Celso Arango, Manuel Arrojo, Miquel Bernardo, Julio Bobes, Lieuwe de Haan, Cristina Del-Ben, Charlotte Gayer-Anderson, Sideli Lucia, Peter Jones, Hannah Jongsma, James Kirkbride, Caterina La Cascia, Antonio Lasalvia, Sarah Tosato, Pierre Michel Llorca, Paulo Menezes, Jim van Os, Quattrone Diego, Bart Rutten, José Santos, Julio Sanjuan, Jean-Paul Selten, Andrei Szöke, Ilaria Tarricone, Andrea Tortelli, Eva Velthorst, Craig Morgan, Emma Dempster, Eilis Hannon, Joe Burrage, Jonathan Mill, Robin Murray, and Chloe Wong
Abstract: Studies conducted in psychotic disorders have shown that DNA-methylation (DNAm) is sensitive to the impact of Childhood Adversity (CA). However, whether it mediates the association between CA and psychosis is yet to be explored. Epigenome-wide association studies (EWAS) using the Illumina Infinium-Methylation EPIC array in peripheral blood tissue from 366 First-episode of psychosis and 517 healthy controls was performed. Polyvictimization scores were created for abuse, neglect, and composite adversity with the Childhood Trauma Questionnaire (CTQ). Regressions examining (I) CTQ scores with psychosis; (II) with DNAm EWAS level and (III), then between DNAm and caseness, adjusted for a variety of confounders were conducted. Divide-Aggregate Composite-null Test for the composite null hypothesis of no mediation effect was conducted. Enrichment analyses were conducted with missMethyl package and the KEGG database. Our results show that CA was associated with psychosis (Composite: OR = 3.09; p =
Published: 2022
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22. Child maltreatment, migration and risk of first-episode psychosis: results from the multinational EU-GEI study

Author: D'Andrea, Giuseppe, primary, Lal, Jatin, additional, Tosato, Sarah, additional, Gayer-Anderson, Charlotte, additional, Jongsma, Hannah E., additional, Stilo, Simona A., additional, van der Ven, Els, additional, Quattrone, Diego, additional, Velthorst, Eva, additional, Berardi, Domenico, additional, Rossi Menezes, Paulo, additional, Arango, Celso, additional, Parellada, Mara, additional, Lasalvia, Antonio, additional, La Cascia, Caterina, additional, Ferraro, Laura, additional, La Barbera, Daniele, additional, Sideli, Lucia, additional, Bobes, Julio, additional, Bernardo, Miguel, additional, Sanjuán, Julio, additional, Santos, Jose Luis, additional, Arrojo, Manuel, additional, Del-Ben, Cristina Marta, additional, Tripoli, Giada, additional, Llorca, Pierre-Michel, additional, de Haan, Lieuwe, additional, Selten, Jean-Paul, additional, Tortelli, Andrea, additional, Szöke, Andrei, additional, Muratori, Roberto, additional, Rutten, Bart P., additional, van Os, Jim, additional, Jones, Peter B., additional, Kirkbride, James B., additional, Murray, Robin M., additional, di Forti, Marta, additional, Tarricone, Ilaria, additional, and Morgan, Craig, additional
Published: 2022
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23. Cannabis users have higher premorbid IQ than other patients with first onset psychosis

Author: Ferraro, Laura, Russo, Manuela, O'Connor, Jennifer, Wiffen, Benjamin D.R., Falcone, Maria Aurora, Sideli, Lucia, Gardner-Sood, Poonam, Stilo, Simona, Trotta, Antonella, Dazzan, Paola, Mondelli, Valeria, Taylor, Heather, Friedman, Bess, Sallis, Hannah, La Cascia, Caterina, La Barbera, Daniele, David, Anthony S., Reichenberg, Abraham, Murray, Robin M., and Di Forti, Marta
Published: 2013
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24. Confirmation that the AKT1 (rs2494732) Genotype Influences the Risk of Psychosis in Cannabis Users

Author: Di Forti, Marta, Iyegbe, Conrad, Sallis, Hannah, Kolliakou, Anna, Falcone, M. Aurora, Paparelli, Alessandra, Sirianni, Miriam, La Cascia, Caterina, Stilo, Simona A., Marques, Tiago Reis, Handley, Rowena, Mondelli, Valeria, Dazzan, Paola, Pariante, Carmine, David, Anthony S., Morgan, Craig, Powell, John, and Murray, Robin M.
Published: 2012
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25. The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI)

Author: Gayer-Anderson, Charlotte, Jongsma, Hannah E., Di Forti, Marta, Quattrone, Diego, Velthorst, Eva, De Haan, Lieuwe, Selten, Jean-Paul, Szöke, Andrei, Llorca, Pierre-Michel, Tortelli, Andrea, Arango, Celso, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, José Luis, Arrojo, Manuel, Parellada, Mara, Tarricone, Ilaria, Berardi, Domenico, Ruggeri, Mirella, Lasalvia, Antonio, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Rutten, Bart P., Van Os, Jim, Jones, Peter B., Murray, Robin M., Kirkbride, James B., Morgan, Craig, Hubbard, Kathryn, Beards, Stephanie, Reininghaus, Ulrich, Tripoli, Giada, Stilo, Simona A., Roldán, Laura, López, Gonzalo, Matteis, Mario, Rapado, Marta, González, Emiliano, Martínez, Covadonga, Cuadrado, Pedro, Solano, José Juan Rodríguez, Carracedo, Angel, Costas, Javier, Bernardo, Enrique García, Sánchez, Emilio, Olmeda, Ma Soledad, Cabrera, Bibiana, Lorente-Rovira, Esther, Garcia-Portilla, Paz, Jiménez-López, Estela, Franke, Nathalie, Van Dam, Daniella, Termorshuizen, Fabian, Van Der Ven, Elsje, Messchaart, Elles, Leboyer, Marion, Schürhoff, Franck, Baudin, Grégoire, Ferchiou, Aziz, Pignon, Baptiste, Jamain, Stéphane, Richard, Jean-Romain, Charpeaud, Thomas, Tronche, Anne-Marie, Frijda, Flora, Sideli, Lucia, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Loureiro, Camila Marcelino, Shuhama, Rosana, Tosato, Sarah, Bonetto, Chiara, Cristofalo, Doriana, Gayer-Anderson, Charlotte [0000-0003-1636-889X], Apollo - University of Cambridge Repository, Gayer-Anderson C., Jongsma H.E., Di Forti M., Quattrone D., Velthorst E., de Haan L., Selten J.-P., Szoke A., Llorca P.-M., Tortelli A., Arango C., Bobes J., Bernardo M., Sanjuan J., Santos J.L., Arrojo M., Parellada M., Tarricone I., Berardi D., Ruggeri M., Lasalvia A., Ferraro L., La Cascia C., La Barbera D., Menezes P.R., Del-Ben C.M., Hubbard K., Beards S., Reininghaus U., Tripoli G., Stilo S.A., Roldan L., Lopez G., Matteis M., Rapado M., Gonzalez E., Martinez C., Cuadrado P., Solano J.J.R., Carracedo A., Costas J., Bernardo E.G., Sanchez E., Olmeda M.S., Cabrera B., Lorente-Rovira E., Garcia-Portilla P., Jimenez-Lopez E., Franke N., van Dam D., Termorshuizen F., van der Ven E., Messchaart E., Leboyer M., Schurhoff F., Baudin G., Ferchiou A., Pignon B., Jamain S., Richard J.-R., Charpeaud T., Tronche A.-M., Frijda F., Sideli L., Seminerio F., Sartorio C., Marrazzo G., Loureiro C.M., Shuhama R., Tosato S., Bonetto C., Cristofalo D., Rutten B.P., van Os J., Jones P.B., Murray R.M., Kirkbride J.B., Morgan C., Gayer-Anderson, Charlotte, Jongsma, Hannah E., Di Forti, Marta, Quattrone, Diego, Velthorst, Eva, de Haan, Lieuwe, Selten, Jean-Paul, Szöke, Andrei, Llorca, Pierre-Michel, Tortelli, Andrea, Arango, Celso, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, José Lui, Arrojo, Manuel, Parellada, Mara, Tarricone, Ilaria, Berardi, Domenico, Ruggeri, Mirella, Lasalvia, Antonio, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Rutten, Bart P., van Os, Jim, Jones, Peter B., Murray, Robin M., Kirkbride, James B., Morgan, Craig, Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), RS: MHeNs - R3 - Neuroscience, MUMC+: Hersen en Zenuw Centrum (3), ANS - Mood, Anxiety, Psychosis, Stress & Sleep, Adult Psychiatry, and APH - Mental Health
Subjects: Male, Health (social science), Epidemiology, Ethnic group, Ethnic Group, Gene-environment interactions, Environment–environment interactions, 0302 clinical medicine, Ethnicity, 10. No inequality, First episode, RISK, biology, Incidence (epidemiology), Incidence, CANNABIS, Middle Aged, Case-control, First-episode psychosis, 3. Good health, Europe, Psychiatry and Mental health, Case–control Environment–environment interactions EU-GEI First-episode psychosis Gene–environment interactions Incidence, Case–control, EU-GEI, Gene–environment interactions, Schizophrenia, Cohort, Female, Psychology, Case-Control Studie, Brazil, Human, Adult, medicine.medical_specialty, Social Psychology, Adolescent, Study Protocols and Samples, DISORDERS, Environment–environment interaction, Representativeness heuristic, 03 medical and health sciences, Young Adult, PSYCHOSIS, AGE, First-episode psychosi, Environment-environment interactions, medicine, Humans, Gene–environment interaction, Settore MED/25 - Psichiatria, METAANALYSIS, biology.organism_classification, medicine.disease, 030227 psychiatry, Case-Control Studies, Gene-Environment Interaction, Cannabis, CHILDHOOD ADVERSITIES, 030217 neurology & neurosurgery, Demography
Abstract: Funder: FP7 Ideas: European Research Council; doi: http://dx.doi.org/10.13039/100011199; Grant(s): HEALTH-F2-2010-241909, Purpose: The EUropean Network of National Schizophrenia Networks Studying Gene–Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and minority ethnic groups; and (2) the role of multiple environmental and genetic risk factors, and their interactions, in the development of psychotic disorders. Methods: Between 2010 and 2015, we identified 2774 incident cases of psychotic disorders during 12.9 million person-years at risk, across 17 sites in 6 countries (UK, The Netherlands, France, Spain, Italy, and Brazil). Of the 2774 incident cases, 1130 cases were assessed in detail and form the case sample for case–control analyses. Across all sites, 1497 controls were recruited and assessed. We collected data on an extensive range of exposures and outcomes, including demographic, clinical (e.g. premorbid adjustment), social (e.g. childhood and adult adversity, cannabis use, migration, discrimination), cognitive (e.g. IQ, facial affect processing, attributional biases), and biological (DNA via blood sample/cheek swab). We describe the methodology of the study and some descriptive results, including representativeness of the cohort. Conclusions: This resource constitutes the largest and most extensive incidence and case–control study of psychosis ever conducted.
Published: 2020
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26. Migration history and risk of psychosis: results from the multinational EU-GEI study

Author: Hersenen-Medisch 1, Brain, Tarricone, Ilaria, D'Andrea, Giuseppe, Jongsma, Hannah E, Tosato, Sarah, Gayer-Anderson, Charlotte, Stilo, Simona A, Suprani, Federico, Iyegbe, Conrad, van der Ven, Els, Quattrone, Diego, di Forti, Marta, Velthorst, Eva, Rossi Menezes, Paulo, Arango, Celso, Parellada, Mara, Lasalvia, Antonio, La Cascia, Caterina, Ferraro, Laura, Bobes, Julio, Bernardo, Miguel, Sanjuán, Iulio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Tripoli, Giada, Llorca, Pierre-Michel, de Haan, Lieuwe, Selten, Jean-Paul, Tortelli, Andrea, Szöke, Andrei, Muratori, Roberto, Rutten, Bart P, van Os, Jim, Jones, Peter B, Kirkbride, James B, Berardi, Domenico, Murray, Robin M, Morgan, Craig, Hersenen-Medisch 1, Brain, Tarricone, Ilaria, D'Andrea, Giuseppe, Jongsma, Hannah E, Tosato, Sarah, Gayer-Anderson, Charlotte, Stilo, Simona A, Suprani, Federico, Iyegbe, Conrad, van der Ven, Els, Quattrone, Diego, di Forti, Marta, Velthorst, Eva, Rossi Menezes, Paulo, Arango, Celso, Parellada, Mara, Lasalvia, Antonio, La Cascia, Caterina, Ferraro, Laura, Bobes, Julio, Bernardo, Miguel, Sanjuán, Iulio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Tripoli, Giada, Llorca, Pierre-Michel, de Haan, Lieuwe, Selten, Jean-Paul, Tortelli, Andrea, Szöke, Andrei, Muratori, Roberto, Rutten, Bart P, van Os, Jim, Jones, Peter B, Kirkbride, James B, Berardi, Domenico, Murray, Robin M, and Morgan, Craig
Published: 2022

27. Pre-morbid Conduct Disorder symptoms are associated with cannabis use among individuals with a first episode of psychosis

Author: Malcolm, Charlotte P., Picchioni, Marco M., DiForti, Marta, Sugranyes, Gisela, Cooke, Elizabeth, Joseph, Candice, McQueen, Grant, Paparelli, Alessandra, Stilo, Simona, O'Connor, Jennifer, Morgan, Craig, Murray, Robin M., and Hodgins, Sheilagh
Published: 2011
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28. Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study.

Author: Rodriguez, Victoria, Alameda, Luis, Quattrone, Diego, Tripoli, Giada, Gayer-Anderson, Charlotte, Spinazzola, Edoardo, Trotta, Giulia, Jongsma, Hannah E., Stilo, Simona, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, Bonora, Elena, Jamain, Stéphane, Selten, Jean-Paul, Velthorst, Eva, and de Haan, Lieuwe
Subjects: GENETICS, CONFIDENCE intervals, SCHIZOPHRENIA, PSYCHOSES, MULTIPLE regression analysis, RISK assessment, AFFECTIVE disorders, DISEASE susceptibility, GENOTYPES, ODDS ratio, PREDICTION models
Abstract: Background: Schizophrenia (SZ), bipolar disorder (BD) and depression (D) run in families. This susceptibility is partly due to hundreds or thousands of common genetic variants, each conferring a fractional risk. The cumulative effects of the associated variants can be summarised as a polygenic risk score (PRS). Using data from the EUropean Network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) first episode case–control study, we aimed to test whether PRSs for three major psychiatric disorders (SZ, BD, D) and for intelligent quotient (IQ) as a neurodevelopmental proxy, can discriminate affective psychosis (AP) from schizophrenia-spectrum disorder (SSD). Methods: Participants (842 cases, 1284 controls) from 16 European EU-GEI sites were successfully genotyped following standard quality control procedures. The sample was stratified based on genomic ancestry and analyses were done only on the subsample representing the European population (573 cases, 1005 controls). Using PRS for SZ, BD, D, and IQ built from the latest available summary statistics, we performed simple or multinomial logistic regression models adjusted for 10 principal components for the different clinical comparisons. Results: In case–control comparisons PRS-SZ, PRS-BD and PRS-D distributed differentially across psychotic subcategories. In case–case comparisons, both PRS-SZ [odds ratio (OR) = 0.7, 95% confidence interval (CI) 0.54–0.92] and PRS-D (OR = 1.31, 95% CI 1.06–1.61) differentiated AP from SSD; and within AP categories, only PRS-SZ differentiated BD from psychotic depression (OR = 2.14, 95% CI 1.23–3.74). Conclusions: Combining PRS for severe psychiatric disorders in prediction models for psychosis phenotypes can increase discriminative ability and improve our understanding of these phenotypes. Our results point towards the potential usefulness of PRSs in specific populations such as high-risk or early psychosis phases. [ABSTRACT FROM AUTHOR]
Published: 2023
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29. Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study

Author: Rodriguez, Victoria, primary, Alameda, Luis, additional, Quattrone, Diego, additional, Tripoli, Giada, additional, Gayer-Anderson, Charlotte, additional, Spinazzola, Edoardo, additional, Trotta, Giulia, additional, Jongsma, Hannah E., additional, Stilo, Simona, additional, La Cascia, Caterina, additional, Ferraro, Laura, additional, La Barbera, Daniele, additional, Lasalvia, Antonio, additional, Tosato, Sarah, additional, Tarricone, Ilaria, additional, Bonora, Elena, additional, Jamain, Stéphane, additional, Selten, Jean-Paul, additional, Velthorst, Eva, additional, de Haan, Lieuwe, additional, Llorca, Pierre-Michel, additional, Arrojo, Manuel, additional, Bobes, Julio, additional, Bernardo, Miguel, additional, Arango, Celso, additional, Kirkbride, James, additional, Jones, Peter B., additional, Rutten, Bart P., additional, Richards, Alexander, additional, Sham, Pak C., additional, O'Donovan, Michael, additional, Van Os, Jim, additional, Morgan, Craig, additional, Di Forti, Marta, additional, Murray, Robin M., additional, and Vassos, Evangelos, additional
Published: 2022
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30. Assessing cross-national invariance of the Community Assessment of Psychic Experiences (CAPE)

Author: Pignon, Baptiste, Peyre, Hugo, Ferchiou, Aziz, van Os, Jim, Rutten, Bart P. F., Murray, Robin M., Morgan, Craig, Leboyer, Marion, Schurhoff, Franck, Szoke, Andrei, Hubbard, Kathryn, Beards, Stephanie, Stilo, Simona A., Parellada, Mara, Cuadrado, Pedro, Rodriguez Solano, Jose Juan, Carracedo, Angel, Garcia Bernardo, Enrique, Roldan, Laura, Lopez, Gonzalo, Cabrera, Bibiana, Lorente-Rovira, Esther, Garcia-Portilla, Paz, Costas, Javier, Jimenez-Lopez, Estela, Matteis, Mario, Rapado, Marta, Gonzalez, Emiliano, Martinez, Covadonga, Sanchez, Emilio, Soledad Olmeda, Ma, Franke, Nathalie, Termorshuizen, Fabian, van Dam, Daniella, van der Ven, Elsje, Messchaart, Elles, Jamain, Stephane, Baudin, Gregoire, Richard, Jean-Romain, Charpeaud, Thomas, Tronche, Anne-Marie, Frijda, Flora, Marrazzo, Giovanna, Sideli, Lucia, Sartorio, Crocettarachele, Seminerio, Fabio, Loureiro, Camila Marcelino, Shuhama, Rosana, Ruggeri, Mirella, Tosato, Sarah, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), MUMC+: Hersen en Zenuw Centrum (3), Psychiatrie & Neuropsychologie, and RS: MHeNs - R3 - Neuroscience
Subjects: Cross-Cultural Comparison, PSYCHOTIC-LIKE EXPERIENCES, DIMENSIONS, Psychometrics, PREDICTION, Schizotypy, Population, schizotypy, VALIDATION, 03 medical and health sciences, Community Assessment of Psychic Experiences (CAPE), 0302 clinical medicine, Surveys and Questionnaires, Statistics, SCHIZOPHRENIA, media_common.cataloged_instance, Humans, Measurement invariance, European union, psychotic experiences, education, Equivalence (measure theory), Categorical variable, Applied Psychology, POPULATION, Factor analysis, media_common, Netherlands, cross-national invariance, education.field_of_study, INSTRUMENT, Confirmatory factor analysis, United Kingdom, 030227 psychiatry, Psychiatry and Mental health, INDIVIDUALS, PSYCHOMETRIC PROPERTIES, Italy, Psychotic Disorders, Spain, Gene-Environment Interaction, France, Psychology, Factor Analysis, Statistical, 030217 neurology & neurosurgery, Brazil
Abstract: BackgroundThe Community Assessment of Psychic Experiences (CAPE) is a 42-item self-report questionnaire that has been developed and validated to measure the dimensions of psychosis in the general population. The CAPE has a three-factor structure with dimensions of positive, negative and depression. Assessing the cross-national equivalence of a questionnaire is an essential prerequisite before pooling data from different countries. In this study, our aim was to investigate the measurement invariance of the CAPE across different countries.MethodsData were drawn from the European Union Gene-Environment Interaction (EU-GEI) study. Participants (incident cases of psychotic disorder, controls and siblings of cases) were recruited in Brazil, France, Italy, the Netherlands, Spain and UK. To analyse the measurement invariance across these samples, we tested configural invariance (i.e. identical structures of the factors), metric invariance (i.e. equivalence of the factor loadings) and scalar invariance (i.e. equivalence of the thresholds) of the three CAPE dimensions using multigroup categorical confirmatory factor analysis methods.ResultsThe configural invariance model fits well, providing evidence for identical factorial structure across countries. In comparison with the configural model invariance, the fit indices were very similar in the metric and scalar invariance models, indicating that factor loadings and thresholds did not differ across the six countries.ConclusionWe found that, across six countries, the CAPE showed equivalent factorial structure, factor loadings and thresholds. Thus, differences observed in scores between individuals from different countries should be considered as reflecting different levels of psychosis.
Published: 2019
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31. Development and Validation of Predictive Model for a Diagnosis of First Episode Psychosis Using the Multinational EU-GEI Case–control Study and Modern Statistical Learning Methods.

Author: Ajnakina, Olesya, Fadilah, Ihsan, Quattrone, Diego, Arango, Celso, Berardi, Domenico, Bernardo, Miguel, Bobes, Julio, Haan, Lieuwe de, Del-Ben, Cristina Marta, Gayer-Anderson, Charlotte, Stilo, Simona, Jongsma, Hannah E, Lasalvia, Antonio, Tosato, Sarah, Llorca, Pierre-Michel, Menezes, Paulo Rossi, Rutten, Bart P, Santos, Jose Luis, Sanjuán, Julio, and Selten, Jean-Paul
Subjects: STATISTICS, RESEARCH, CANNABIS (Genus), SUBSTANCE abuse, SAMPLE size (Statistics), CONFIDENCE intervals, PSYCHOSES, CASE-control method, LEARNING strategies, RISK assessment, COMPARATIVE studies, THEORY, DESCRIPTIVE statistics, PREDICTION models, RECEIVER operating characteristic curves, DATA analysis software, ODDS ratio
Abstract: Background and Hypothesis It is argued that availability of diagnostic models will facilitate a more rapid identification of individuals who are at a higher risk of first episode psychosis (FEP). Therefore, we developed, evaluated, and validated a diagnostic risk estimation model to classify individual with FEP and controls across six countries. Study Design We used data from a large multi-center study encompassing 2627 phenotypically well-defined participants (aged 18–64 years) recruited from six countries spanning 17 research sites, as part of the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions study. To build the diagnostic model and identify which of important factors for estimating an individual risk of FEP, we applied a binary logistic model with regularization by the least absolute shrinkage and selection operator. The model was validated employing the internal-external cross-validation approach. The model performance was assessed with the area under the receiver operating characteristic curve (AUROC), calibration, sensitivity, and specificity. Study Results Having included preselected 22 predictor variables, the model was able to discriminate adults with FEP and controls with high accuracy across all six countries (rangesAUROC = 0.84–0.86). Specificity (range = 73.9–78.0%) and sensitivity (range = 75.6–79.3%) were equally good, cumulatively indicating an excellent model accuracy; though, calibration slope for the diagnostic model showed a presence of some overfitting when applied specifically to participants from France, the UK, and The Netherlands. Conclusions The new FEP model achieved a good discrimination and good calibration across six countries with different ethnic contributions supporting its robustness and good generalizability. [ABSTRACT FROM AUTHOR]
Published: 2023
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32. First-Episode Psychosis Patients Who Deteriorated in the Premorbid Period Do Not Have Higher Polygenic Risk Scores Than Others: A Cluster Analysis of EU-GEI Data.

Author: Ferraro, Laura, Quattrone, Diego, Barbera, Daniele La, Cascia, Caterina La, Morgan, Craig, Kirkbride, James B, Cardno, Alastair G, Sham, Pak, Tripoli, Giada, Sideli, Lucia, Seminerio, Fabio, Sartorio, Crocettarachele, Szoke, Andrei, Tarricone, Ilaria, Bernardo, Miquel, Rodriguez, Victoria, Stilo, Simona A, Gayer-Anderson, Charlotte, Haan, Lieuwe de, and Velthorst, Eva
Subjects: SCHIZOPHRENIA risk factors, ACADEMIC achievement evaluation, MENTAL depression risk factors, SUBSTANCE abuse, CANNABIS (Genus), CONFIDENCE intervals, PSYCHOSES, GENETIC variation, RISK assessment, COMPARATIVE studies, DESCRIPTIVE statistics, SOCIAL skills, CLUSTER analysis (Statistics), BIPOLAR disorder, DISEASE risk factors, DISEASE complications, CHILDREN, ADOLESCENCE
Abstract: Cluster studies identified a subgroup of patients with psychosis whose premorbid adjustment deteriorates before the onset, which may reflect variation in genetic influence. However, other studies reported a complex relationship between distinctive patterns of cannabis use and cognitive and premorbid impairment that is worthy of consideration. We examined whether: (1) premorbid social functioning (PSF) and premorbid academic functioning (PAF) in childhood and adolescence and current intellectual quotient (IQ) define different clusters in 802 first-episode of psychosis (FEP) patients; resulting clusters vary in (2) polygenic risk scores (PRSs) for schizophrenia (SCZ_PRS), bipolar disorder (BD_PRS), major depression (MD_PRS), and IQ (IQ_PRS), and (3) patterns of cannabis use, compared to 1,263 population-based controls. Four transdiagnostic clusters emerged (BIC = 2268.5): (1) high-cognitive-functioning (n = 205), with the highest IQ (Mean = 106.1, 95% CI: 104.3, 107.9) and PAF, but low PSF. (2) Low-cognitive-functioning (n = 223), with the lowest IQ (Mean = 73.9, 95% CI: 72.2, 75.7) and PAF, but normal PSF. (3) Intermediate (n = 224) (Mean_IQ = 80.8, 95% CI: 79.1, 82.5) with low-improving PAF and PSF. 4) Deteriorating (n = 150) (Mean_IQ = 80.6, 95% CI: 78.5, 82.7), with normal-deteriorating PAF and PSF. The PRSs explained 7.9% of between-group membership. FEP had higher SCZ_PRS than controls [ F (4,1319) = 20.4, P < .001]. Among the clusters, the deteriorating group had lower SCZ_PRS and was likelier to have used high-potency cannabis daily. Patients with FEP clustered according to their premorbid and cognitive abilities. Pronounced premorbid deterioration was not typical of most FEP, including those more strongly predisposed to schizophrenia, but appeared in a cluster with a history of high-potency cannabis use. [ABSTRACT FROM AUTHOR]
Published: 2023
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33. The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study

Author: Quattrone, Diego, Reininghaus, Ulrich, Richards, Alex L., Tripoli, Giada, Ferraro, Laura, Quattrone, Andrea, Marino, Paolo, Rodriguez, Victoria, Spinazzola, Edoardo, Gayer-Anderson, Charlotte, Jongsma, Hannah E., Jones, Peter B., La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Bonora, Elena, Tosato, Sarah, Lasalvia, Antonio, Szöke, Andrei, Arango, Celso, Bernardo, Miquel, Bobes, Julio, Del Ben, Cristina Marta, Menezes, Paulo Rossi, Llorca, Pierre-Michel, Santos, Jose Luis, Sanjuán, Julio, Arrojo, Manuel, Tortelli, Andrea, Velthorst, Eva, Berendsen, Steven, De Haan, Lieuwe, Rutten, Bart P. F., Lynskey, Michael T., Freeman, Tom P., Kirkbride, James B., Sham, Pak C., O’Donovan, Michael C., Cardno, Alastair G., Vassos, Evangelos, Van Os, Jim, Morgan, Craig, Murray, Robin M., Lewis, Cathryn M., Di Forti, Marta, Hubbard, Kathryn, Beards, Stephanie, Stilo, Simona A., Parellada, Mara, Fraguas, David, Castro, Marta Rapado, Andreu-Bernabeu, Álvaro, López, Gonzalo, Matteis, Mario, González, Emiliano, Durán-Cutilla, Manuel, Díaz-Caneja, Covadonga M., Cuadrado, Pedro, Rodríguez Solano, José Juan, Carracedo, Angel, Costas, Javier, Sánchez, Emilio, Amoretti, Silvia, Lorente-Rovira, Esther, Garcia-Portilla, Paz, Jiménez-López, Estela, Franke, Nathalie, Van Dam, Daniella, Termorshuizen, Fabian, Van Der Ven, Elsje, Messchaart, Elles, Leboyer, Marion, Schürhoff, Franck, Jamain, Stéphane, Baudin, Grégoire, Ferchiou, Aziz, Pignon, Baptiste, Richard, Jean-Romain, Charpeaud, Thomas, Tronche, Anne-Marie, Frijda, Flora, Marrazzo, Giovanna, Sideli, Lucia, Sartorio, Crocettarachele, Seminerio, Fabio, Loureiro, Camila Marcelino, Shuhama, Rosana, Ruggeri, Mirella, Bonetto, Chiara, Cristofalo, Doriana, Berardi, Domenico, Seri, Marco, D’Andrea, Giuseppe, Quattrone, Diego [0000-0002-6051-8309], Richards, Alex L. [0000-0003-3218-7247], Marino, Paolo [0000-0003-3571-1753], Rodriguez, Victoria [0000-0003-0383-0846], Jones, Peter B. [0000-0002-0387-880X], Tosato, Sarah [0000-0002-9665-7538], Bernardo, Miquel [0000-0001-8748-6717], Bobes, Julio [0000-0003-2187-4033], Del Ben, Cristina Marta [0000-0003-0145-9975], Menezes, Paulo Rossi [0000-0001-6330-3314], Llorca, Pierre-Michel [0000-0001-7438-8990], Rutten, Bart P. F. [0000-0002-9834-6346], Kirkbride, James B. [0000-0003-3401-0824], O’Donovan, Michael C. [0000-0001-7073-2379], Vassos, Evangelos [0000-0001-6363-0438], Murray, Robin M. [0000-0003-0829-0519], Lewis, Cathryn M. [0000-0002-8249-8476], and Apollo - University of Cambridge Repository
Subjects: 45, 692/699/476/1799, 692/53/2423, 45/43, article, 631/208/2489
Abstract: Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of cannabis use on the transdiagnostic expression of psychosis. We analysed first-episode psychosis patients (FEP) and controls, generating transdiagnostic dimensions of psychotic symptoms and experiences using item response bi-factor modelling. Linear regression was used to test the associations between these dimensions and SZ-PRS, as well as the combined effect of SZ-PRS and cannabis use on the dimensions of positive psychotic symptoms and experiences. We found associations between SZ-PRS and (1) both negative (B = 0.18; 95%CI 0.03–0.33) and positive (B = 0.19; 95%CI 0.03–0.35) symptom dimensions in 617 FEP patients, regardless of their categorical diagnosis; and (2) all the psychotic experience dimensions in 979 controls. We did not observe associations between SZ-PRS and the general and affective dimensions in FEP. Daily and current cannabis use were associated with the positive dimensions in FEP (B = 0.31; 95%CI 0.11–0.52) and in controls (B = 0.26; 95%CI 0.06–0.46), over and above SZ-PRS. We provide evidence that genetic liability to schizophrenia and cannabis use map onto transdiagnostic symptom dimensions, supporting the validity and utility of the dimensional representation of psychosis. In our sample, genetic liability to schizophrenia correlated with more severe psychosis presentation, and cannabis use conferred risk to positive symptomatology beyond the genetic risk. Our findings support the hypothesis that psychotic experiences in the general population have similar genetic substrates as clinical disorders.
Published: 2021
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34. Jumping to Conclusions, Neuropsychological Functioning, and Delusional Beliefs in First Episode Psychosis

Author: Falcone, M. Aurora, Murray, Robin M., Wiffen, Benjamin D. R., O’Connor, Jennifer A., Russo, Manuela, Kolliakou, Anna, Stilo, Simona, Taylor, Heather, Gardner-Sood, Poonam, Paparelli, Alessandra, Jichi, Fatima, Di Forti, Marta, David, Anthony S., Freeman, Daniel, and Jolley, Suzanne
Published: 2015
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35. Depression, Anxiety and Anger in Subtypes of Irritable Bowel Syndrome Patients

Author: Muscatello, Maria Rosaria A., Bruno, Antonio, Pandolfo, Gianluca, Micò, Umberto, Stilo, Simona, Scaffidi, Mariagrazia, Consolo, Pierluigi, Tortora, Andrea, Pallio, Socrate, Giacobbe, Giuseppa, Familiari, Luigi, and Zoccali, Rocco
Published: 2010
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36. Daily Use, Especially of High-Potency Cannabis, Drives the Earlier Onset of Psychosis in Cannabis Users

Author: Di Forti, Marta, Sallis, Hannah, Allegri, Fabio, Trotta, Antonella, Ferraro, Laura, Stilo, Simona A., Marconi, Arianna, La Cascia, Caterina, Reis Marques, Tiago, Pariante, Carmine, Dazzan, Paola, Mondelli, Valeria, Paparelli, Alessandra, Kolliakou, Anna, Prata, Diana, Gaughran, Fiona, David, Anthony S., Morgan, Craig, Stahl, Daniel, Khondoker, Mizanur, MacCabe, James H., and Murray, Robin M.
Published: 2014
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37. Migration history and risk of psychosis: results from the multinational EU-GEI study.

Author: Tarricone, Ilaria, D'Andrea, Giuseppe, Jongsma, Hannah E., Tosato, Sarah, Gayer-Anderson, Charlotte, Stilo, Simona A., Suprani, Federico, Iyegbe, Conrad, van der Ven, Els, Quattrone, Diego, di Forti, Marta, Velthorst, Eva, Rossi Menezes, Paulo, Arango, Celso, Parellada, Mara, Lasalvia, Antonio, La Cascia, Caterina, Ferraro, Laura, Bobes, Julio, and Bernardo, Miguel
Subjects: IMMIGRANTS, ADVERSE childhood experiences, CONFIDENCE intervals, SOCIAL support, CANNABIS (Genus), SUBSTANCE abuse, PSYCHOSES, SCHIZOPHRENIA, MULTIPLE regression analysis, PSYCHOLOGICAL vulnerability, EMIGRATION & immigration, CASE-control method, ECOLOGY, MANN Whitney U Test, FISHER exact test, SOCIOECONOMIC factors, RISK assessment, GENES, DESCRIPTIVE statistics, AGE factors in disease, QUESTIONNAIRES, CHI-squared test, EMPLOYMENT, STATISTICAL models, ODDS ratio, STATISTICAL sampling, DATA analysis software, DOSE-response relationship in biochemistry, FAMILY history (Medicine), EDUCATIONAL attainment
Abstract: Background: Psychosis rates are higher among some migrant groups. We hypothesized that psychosis in migrants is associated with cumulative social disadvantage during different phases of migration. Methods: We used data from the EUropean Network of National Schizophrenia Networks studying Gene-Environment Interactions (EU-GEI) case–control study. We defined a set of three indicators of social disadvantage for each phase: pre-migration, migration and post-migration. We examined whether social disadvantage in the pre- and post-migration phases, migration adversities, and mismatch between achievements and expectations differed between first-generation migrants with first-episode psychosis and healthy first-generation migrants, and tested whether this accounted for differences in odds of psychosis in multivariable logistic regression models. Results: In total, 249 cases and 219 controls were assessed. Pre-migration (OR 1.61, 95% CI 1.06–2.44, p = 0.027) and post-migration social disadvantages (OR 1.89, 95% CI 1.02–3.51, p = 0.044), along with expectations/achievements mismatch (OR 1.14, 95% CI 1.03–1.26, p = 0.014) were all significantly associated with psychosis. Migration adversities (OR 1.18, 95% CI 0.672–2.06, p = 0.568) were not significantly related to the outcome. Finally, we found a dose–response effect between the number of adversities across all phases and odds of psychosis (⩾6: OR 14.09, 95% CI 2.06–96.47, p = 0.007). Conclusions: The cumulative effect of social disadvantages before, during and after migration was associated with increased odds of psychosis in migrants, independently of ethnicity or length of stay in the country of arrival. Public health initiatives that address the social disadvantages that many migrants face during the whole migration process and post-migration psychological support may reduce the excess of psychosis in migrants. [ABSTRACT FROM AUTHOR]
Published: 2022
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38. Cannabis Use Cessation and the Risk of Psychotic Disorders: A Case–Control Analysis from the First Episode Case–Control EU-GEI WP2 Study: L’arrêt de l’utilisation du cannabis et le risque de troubles psychotiques: Une analyse cas-témoins tirée de l’étude cas-témoins EU-GEI WP2 centrée sur les premiers épisodes psychotiques

Author: Bond, Benjamin W., Duric, Bea, Spinazzola, Edoardo, Trotta, Giulia, Chesney, Edward, Li, Zhikun, Quattrone, Diego, Tripoli, Giada, Gayer-Anderson, Charlotte, Rodriguez, Victoria, Ferraro, Laura, La Cascia, Caterina, Tarricone, Ilaria, Szöke, Andrei, Arango, Celso, Bobes, Julio, Bernardo, Miquel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Rutten, Bart P. F., de Haan, Lieuwe, Stilo, Simona, Schürhoff, Franck, Pignon, Baptiste, Freeman, Tom P., Vassos, Evangelos, Murray, Robin M., Austin-Zimmerman, Isabelle, and Di Forti, Marta
Abstract: Objectives To establish whether the risk of psychotic disorders in cannabis users changes with time following cannabis cessation using data from the European Network of National Networks studying Gene–Environment Interactions in Schizophrenia (EU-GEI) case–control study.Methods The EU-GEI case–control study collected data from first episode psychosis patients and population controls across sites in Europe and Brazil between May 2010 and April 2015. Adjusted logistic regressions were applied to examine whether the odd of psychosis case status changed: (1) with time following cannabis cessation and (2) across different cannabis use groups.Results Psychosis risk declined following cessation of cannabis use (β = −0.002; 95% CI −0.004 to 0.000; P= 0.067). When accounting for duration of use, this effect remained (β = −0.003; 95% CI −0.005 to −0.001; P= 0.013). However, in models adjusting for frequency and potency of use the result was not significant. Analysis of different cannabis use groups indicated that ex-users who stopped 1 to 4 weeks previously had the highest risk for psychotic disorder compared to never users (OR = 6.89; 95% CI 3.91–12.14; P< 0.001); risk declined for those who stopped 5 to 12 weeks previously (OR = 2.70; 95% CI 1.73–4.21; P< 0.001) and 13 to 36 weeks previously (OR = 1.53; 95% CI 1.00–2.33; P= 0.050). Ex-users who stopped 37 to 96 weeks (OR = 1.01; 95% CI 0.66–1.57; P= 0.949), 97 to 180 weeks (OR = 0.73; 95% CI 0.45–1.19; P= 0.204), and 181 weeks previously or more (OR = 1.18; 95% CI 0.76–1.83; P= 0.456) had similar psychosis risk to those who had never-used cannabis.Conclusion Risk of psychotic disorder appears to decline with time following cannabis cessation, receding to that of those who have never used cannabis after 37 weeks or more of abstinence. Although, preliminary results suggest that frequent users of high potency types of cannabis might maintain an elevated risk compared to never users even when abstaining for longer than 181 weeks.
Published: 2025
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39. Premorbid Adjustment and IQ in Patients With First-Episode Psychosis: A Multisite Case-Control Study of Their Relationship With Cannabis Use

Author: Ferraro, Laura, La Cascia, Caterina, Quattrone, Diego, Sideli, Lucia, Matranga, Domenica, Capuccio, Veronica, Tripoli, Giada, Gayer-Anderson, Charlotte, Morgan, Craig, Sami, Musa B., Sham, Pak, de Haan, Lieuwe, Velthorst, Eva, Jongsma, Hannah E., Kirkbride, James B., Rutten, Bart P. F., Richards, Alexander L., Roldan, Laura, Arango, Celso, Bernardo, Miquel, Bobes, Julio, Sanjuan, Julio, Santos, Jose Luis, Arrojo, Manuel, Tarricone, Ilaria, Tortelli, Andrea, Del-Ben, Cristina Marta, Selten, Jean-Paul, Lynskey, Michael, Jones, Peter B., Van Os, Jim, La Barbera, Daniele, Murray, Robin M., Di Forti, Marta, WP2 EU-GEI GROUP, Amoretti, Silvia, Beards, Stephanie, Berardi, Domenico, Bonetto, Chiara, Cabrera, Bibiana, Carracedo, Angel, Charpeaud, Thomas, Costas, Javier, Cristofalo, Doriana, Cuadrado, Pedro, Ferchiou, Aziz, Franke, Nathalie, Frijda, Flora, Garcia-Portilla, Paz, Hubbard, Kathryn, Lasalvia, Antonio, Leboyer, Marion, Lorente-Rovira, Esther, Marcelino Loureiro, Camila, Marrazzo, Giovanna, Matteis, Mario, Messchaart, Elles, Moreno, Carmen, Juan, Nacher, Olmeda, Ma Soledad, Parellada, Mara, Pignon, Baptiste, Rapado, Marta, Richard, Jean-Romain, Rossi Menezes, Paulo, Ruggeri, Mirella, Sartorio, Crocettarachele, Schu?rhoff, Franck, Seminerio, Fabio, Shuhama, Rosana, Stilo, Simona A, Termorshuizen, Fabian, Tosato, Sarah, Tronche, Anne-Marie, van Dam, Daniella, and van der Ven, Elsje
Subjects: Psychiatry and Mental health
Published: 2020

40. Use of multiple Polygenic Risk Scores for distinguishing Schizophrenia-spectrum disorder and Affective psychosis categories; the EUGEI study

Author: Rodriguez, Victoria, primary, Alameda, Luis, additional, Quattrone, Diego, additional, Tripoli, Giada, additional, Gayer-Anderson, Charlotte, additional, Spinazzola, Edoardo, additional, Trotta, Giulia, additional, Jongsma, Hannah E, additional, Stilo, Simona, additional, Cascia, Caterina La, additional, Ferraro, Laura, additional, Barbera, Daniele La, additional, Lasalvia, Antonio, additional, Tosato, Sarah, additional, Tarricone, Ilaria, additional, Bonora, Elena, additional, Jamain, Stéphane, additional, Selten, Jean-Paul, additional, Velthorst, Eva, additional, de Haan, Lieuwe, additional, Llorca, Pierre-Michel, additional, Arrojo, Manuel, additional, Bobes, Julio, additional, Bernardo, Miguel, additional, Arango, Celso, additional, Kirkbride, James, additional, Jones, Peter B, additional, Rutten, Bart P, additional, Richards, Alexander, additional, Sham, Pak C, additional, O’Donovan, Michael, additional, Van Os, Jim, additional, Morgan, Craig, additional, Forti, Marta Di, additional, Murray, Robin M, additional, and Vassos, Evangelos, additional
Published: 2021
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41. Social Disadvantage: Cause or Consequence of Impending Psychosis?

Author: Stilo, Simona A., Di Forti, Marta, Mondelli, Valeria, Falcone, Aurora M., Russo, Manuela, O’Connor, Jennifer, Palmer, Emma, Paparelli, Alessandra, Kolliakou, Anna, Sirianni, Miriam, Taylor, Heather, Handley, Rowena, Dazzan, Paola, Pariante, Carmine, Marques, Tiago R., Zoccali, Rocco, David, Anthony, Murray, Robin M., and Morgan, Craig
Published: 2013
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42. Migration history and risk of psychosis: results from the multinational EU-GEI study

Author: Tarricone, Ilaria, primary, D'Andrea, Giuseppe, additional, Jongsma, Hannah E., additional, Tosato, Sarah, additional, Gayer-Anderson, Charlotte, additional, Stilo, Simona A., additional, Suprani, Federico, additional, Iyegbe, Conrad, additional, van der Ven, Els, additional, Quattrone, Diego, additional, di Forti, Marta, additional, Velthorst, Eva, additional, Rossi Menezes, Paulo, additional, Arango, Celso, additional, Parellada, Mara, additional, Lasalvia, Antonio, additional, La Cascia, Caterina, additional, Ferraro, Laura, additional, Bobes, Julio, additional, Bernardo, Miguel, additional, Sanjuán, Iulio, additional, Santos, Jose Luis, additional, Arrojo, Manuel, additional, Del-Ben, Cristina Marta, additional, Tripoli, Giada, additional, Llorca, Pierre-Michel, additional, de Haan, Lieuwe, additional, Selten, Jean-Paul, additional, Tortelli, Andrea, additional, Szöke, Andrei, additional, Muratori, Roberto, additional, Rutten, Bart P., additional, van Os, Jim, additional, Jones, Peter B., additional, Kirkbride, James B., additional, Berardi, Domenico, additional, Murray, Robin M., additional, and Morgan, Craig, additional
Published: 2021
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43. The role of high potency cannabis use and psychosis genetic liability in moderating the risk for onset of psychotic disorders

Author: Di Forti, Marta, Morgan, Craig, Stilo, Simona, Papparelli, Alessandra, Falcone, Aurora, Luzi, Sonija, Marques, Tiago Reis, Mondelli, Valeria, Casadio, Paola, Russo, Manuela, Wiffen, Ben, Dazzan, Paola, Pariante, Carmine, Flach, Clare, Powell, John, and Murray, Robin M
Published: 2010

44. High-potency cannabis and the risk of psychosis

Author: Forti, Marta Di, Morgan, Craig, Dazzan, Paola, Pariante, Carmine, Mondelli, Valeria, Marques, Tiago Reis, Handley, Rowena, Luzi, Sonija, Russo, Manuela, Paparelli, Alessandra, Butt, Alexander, Stilo, Simona A., Wiffen, Ben, Powell, John, and Murray, Robin M.
Published: 2009
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45. Transdiagnostic dimensions of psychopathology at first episode psychosis: findings from the multinational EU-GEI study

Author: Quattrone, Diego, Di Forti, Marta, Gayer-Anderson, Charlotte, Ferraro, Laura, Jongsma, Hannah E., Tripoli, Giada, La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Berardi, Domenico, Szoke, Andrei, Arango, Celso, Lasalvia, Antonio, Tortelli, Andrea, Llorca, Pierre-Michel, de Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuan, Julio, Luis Santos, Jose, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B., Kirkbride, James B., Richards, Alexander L., O'Donovan, Michael C., Sham, Pak C., Vassos, Evangelos, Rutten, Bart P. F., van Os, Jim, Morgan, Craig, Lewis, Cathryn M., Murray, Robin M., Reininghaus, Ulrich, Hubbard, Kathryn, Beards, Stephanie, Stilo, Simona A., Parellada, Mara, Cuadrado, Pedro, Rodriguez Solano, Jose Juan, Carracedo, Angel, Garcia Bernardo, Enrique, Roldan, Laura, Lopez, Gonzalo, Cabrera, Bibiana, Lorente-Rovira, Esther, Garcia-Portilla, Paz, Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), RS: MHeNs - R3 - Neuroscience, and MUMC+: Hersen en Zenuw Centrum (3)
Subjects: GENDER-DIFFERENCES, NEGATIVE SYNDROME SCALE, SEX-DIFFERENCES, first episode psychosis, 5-FACTOR MODEL, Bifactor model, WORKING GROUP, BIPOLAR DISORDER, psychopathology, GENETIC-RELATIONSHIPS, DSM-V, diagnostic categories, symptom dimensions
Abstract: Background. The value of the nosological distinction between non-affective and affective psychosis has frequently been challenged. We aimed to investigate the transdiagnostic dimensional structure and associated characteristics of psychopathology at First Episode Psychosis (FEP). Regardless of diagnostic categories, we expected that positive symptoms occurred more frequently in ethnic minority groups and in more densely populated environments, and that negative symptoms were associated with indices of neurodevelopmental impairment. Method. This study included 2182 FEP individuals recruited across six countries, as part of the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Symptom ratings were analysed using multidimensional item response modelling in Mplus to estimate five theory-based models of psychosis. We used multiple regression models to examine demographic and context factors associated with symptom dimensions. Results. A bifactor model, composed of one general factor and five specific dimensions of positive, negative, disorganization, manic and depressive symptoms, best-represented associations among ratings of psychotic symptoms. Positive symptoms were more common in ethnic minority groups. Urbanicity was associated with a higher score on the general factor. Men presented with more negative and less depressive symptoms than women. Early age-at-first-contact with psychiatric services was associated with higher scores on negative, disorganized, and manic symptom dimensions. Conclusions. Our results suggest that the bifactor model of psychopathology holds across diagnostic categories of non-affective and affective psychosis at FEP, and demographic and context determinants map onto general and specific symptom dimensions. These findings have implications for tailoring symptom-specific treatments and inform research into the mood-psychosis spectrum.
Published: 2019

46. The Maudsley environmental risk score for psychosis

Author: Vassos, Evangelos, primary, Sham, Pak, additional, Kempton, Matthew, additional, Trotta, Antonella, additional, Stilo, Simona A., additional, Gayer-Anderson, Charlotte, additional, Di Forti, Marta, additional, Lewis, Cathryn M., additional, Murray, Robin M., additional, and Morgan, Craig, additional
Published: 2019
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47. The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study

Author: Di Forti, Marta, primary, Quattrone, Diego, additional, Freeman, Tom P, additional, Tripoli, Giada, additional, Gayer-Anderson, Charlotte, additional, Quigley, Harriet, additional, Rodriguez, Victoria, additional, Jongsma, Hannah E, additional, Ferraro, Laura, additional, La Cascia, Caterina, additional, La Barbera, Daniele, additional, Tarricone, Ilaria, additional, Berardi, Domenico, additional, Szöke, Andrei, additional, Arango, Celso, additional, Tortelli, Andrea, additional, Velthorst, Eva, additional, Bernardo, Miguel, additional, Del-Ben, Cristina Marta, additional, Menezes, Paulo Rossi, additional, Selten, Jean-Paul, additional, Jones, Peter B, additional, Kirkbride, James B, additional, Rutten, Bart PF, additional, de Haan, Lieuwe, additional, Sham, Pak C, additional, van Os, Jim, additional, Lewis, Cathryn M, additional, Lynskey, Michael, additional, Morgan, Craig, additional, Murray, Robin M, additional, Amoretti, Silvia, additional, Arrojo, Manuel, additional, Baudin, Grégoire, additional, Beards, Stephanie, additional, Bernardo, Miquel, additional, Bobes, Julio, additional, Bonetto, Chiara, additional, Cabrera, Bibiana, additional, Carracedo, Angel, additional, Charpeaud, Thomas, additional, Costas, Javier, additional, Cristofalo, Doriana, additional, Cuadrado, Pedro, additional, Díaz-Caneja, Covadonga M, additional, Ferchiou, Aziz, additional, Franke, Nathalie, additional, Frijda, Flora, additional, García Bernardo, Enrique, additional, Garcia-Portilla, Paz, additional, González, Emiliano, additional, Hubbard, Kathryn, additional, Jamain, Stéphane, additional, Jiménez-López, Estela, additional, Leboyer, Marion, additional, López Montoya, Gonzalo, additional, Lorente-Rovira, Esther, additional, Marcelino Loureiro, Camila, additional, Marrazzo, Giovanna, additional, Martínez, Covadonga, additional, Matteis, Mario, additional, Messchaart, Elles, additional, Moltó, Ma Dolores, additional, Nacher, Juan, additional, Olmeda, Ma Soledad, additional, Parellada, Mara, additional, González Peñas, Javier, additional, Pignon, Baptiste, additional, Rapado, Marta, additional, Richard, Jean-Romain, additional, Rodríguez Solano, José Juan, additional, Roldán Díaz, Laura, additional, Ruggeri, Mirella, additional, Sáiz, Pilar A., additional, Sánchez, Emilio, additional, Sanjuán, Julio, additional, Sartorio, Crocettarachele, additional, Schürhoff, Franck, additional, Seminerio, Fabio, additional, Shuhama, Rosana, additional, Sideli, Lucia, additional, Stilo, Simona A, additional, Termorshuizen, Fabian, additional, Tosato, Sarah, additional, Tronche, Anne-Marie, additional, van Dam, Daniella, additional, and van der Ven, Elsje, additional
Published: 2019
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48. Transdiagnostic dimensions of psychopathology at first episode psychosis: findings from the multinational EU-GEI study

Author: Brain, Hersenen-Medisch 1, HAG Netwerken, Quattrone, Diego, Di Forti, Marta, Gayer-Anderson, Charlotte, Ferraro, Laura, Jongsma, Hannah E., Tripoli, Giada, La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Berardi, Domenico, Szoke, Andrei, Arango, Celso, Lasalvia, Antonio, Tortelli, Andrea, Llorca, Pierre-Michel, de Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuan, Julio, Luis Santos, Jose, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B., Kirkbride, James B., Richards, Alexander L., O'Donovan, Michael C., Sham, Pak C., Vassos, Evangelos, Rutten, Bart P. F., van Os, Jim, Morgan, Craig, Lewis, Cathryn M., Murray, Robin M., Reininghaus, Ulrich, Hubbard, Kathryn, Beards, Stephanie, Stilo, Simona A., Parellada, Mara, Cuadrado, Pedro, Rodriguez Solano, Jose Juan, Carracedo, Angel, Garcia Bernardo, Enrique, Roldan, Laura, Lopez, Gonzalo, Cabrera, Bibiana, Lorente-Rovira, Esther, Garcia-Portilla, Paz, Costas, Javier, Jimenez-Lopez, Estela, Matteis, Mario, Rapado, Marta, Gonzalez, Emiliano, Martinez, Covadonga, Sanchez, Emilio, Olmeda, Ma Soledad, Franke, Nathalie, Termorshuizen, Fabian, van Dam, Daniella, van der Ven, Elsje, Messchaart, Elles, Leboyer, Marion, Schurhoff, Franck, Jamain, Stephane, Baudin, Gregoire, Ferchiou, Aziz, Pignon, Baptiste, Richard, Jean-Romain, Charpeaud, Thomas, Tronche, Anne-Marie, Frijda, Flora, Marrazzo, Giovanna, Sideli, Lucia, Sartorio, Crocettarachele, Seminerio, Fabio, Loureiro, Camila Marcelino, Shuhama, Rosana, Ruggeri, Mirella, Tosato, Sarah, Bonetto, Chiara, Cristofalo, Doriana, Brain, Hersenen-Medisch 1, HAG Netwerken, Quattrone, Diego, Di Forti, Marta, Gayer-Anderson, Charlotte, Ferraro, Laura, Jongsma, Hannah E., Tripoli, Giada, La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Berardi, Domenico, Szoke, Andrei, Arango, Celso, Lasalvia, Antonio, Tortelli, Andrea, Llorca, Pierre-Michel, de Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuan, Julio, Luis Santos, Jose, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B., Kirkbride, James B., Richards, Alexander L., O'Donovan, Michael C., Sham, Pak C., Vassos, Evangelos, Rutten, Bart P. F., van Os, Jim, Morgan, Craig, Lewis, Cathryn M., Murray, Robin M., Reininghaus, Ulrich, Hubbard, Kathryn, Beards, Stephanie, Stilo, Simona A., Parellada, Mara, Cuadrado, Pedro, Rodriguez Solano, Jose Juan, Carracedo, Angel, Garcia Bernardo, Enrique, Roldan, Laura, Lopez, Gonzalo, Cabrera, Bibiana, Lorente-Rovira, Esther, Garcia-Portilla, Paz, Costas, Javier, Jimenez-Lopez, Estela, Matteis, Mario, Rapado, Marta, Gonzalez, Emiliano, Martinez, Covadonga, Sanchez, Emilio, Olmeda, Ma Soledad, Franke, Nathalie, Termorshuizen, Fabian, van Dam, Daniella, van der Ven, Elsje, Messchaart, Elles, Leboyer, Marion, Schurhoff, Franck, Jamain, Stephane, Baudin, Gregoire, Ferchiou, Aziz, Pignon, Baptiste, Richard, Jean-Romain, Charpeaud, Thomas, Tronche, Anne-Marie, Frijda, Flora, Marrazzo, Giovanna, Sideli, Lucia, Sartorio, Crocettarachele, Seminerio, Fabio, Loureiro, Camila Marcelino, Shuhama, Rosana, Ruggeri, Mirella, Tosato, Sarah, Bonetto, Chiara, and Cristofalo, Doriana
Published: 2019

49. Treated incidence of psychotic disorders in the multinational EU-GEI study

Author: Jongsma, Hannah E., Gayer-Anderson, Charlotte, Lasalvia, Antonio, Quattrone, Diego, Mulè, Alice, Szöke, Andrei, Selten, Jean Paul, Turner, Caitlin, Arango, Celso, Tarricone, Ilaria, Berardi, Domenico, Tortelli, Andrea, Llorca, Pierre Michel, De Haan, Lieuwe, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, José Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Murray, Robin M., Rutten, Bart P., Jones, Peter B., Van Os, Jim, Morgan, Craig, Kirkbride, James B., Reininghaus, Ulrich, Di Forti, Marta, Hubbard, Kathryn, Beards, Stephanie, Stilo, Simona A., Tripoli, Giada, Parellada, Mara, Cuadrado, Pedro, Solano, José Juan Rodríguez, Carracedo, Angel, Bernardo, Enrique García, Roldán, Laura, López, Gonzalo, Cabrera, Bibiana, Lorente-Rovira, Esther, Garcia-Portilla, Paz, Costas, Javier, Jiménez-López, Estela, Matteis, Mario, Rapado, Marta, González, Emiliano, Martínez, Covadonga, and Termorshuizen, Fabian
Subjects: Psychiatry and Mental health
Abstract: IMPORTANCE Psychotic disorders contribute significantly to the global disease burden, yet the latest international incidence study of psychotic disorders was conducted in the 1980s. OBJECTIVES To estimate the incidence of psychotic disorders using comparable methods across 17 catchment areas in 6 countries and to examine the variance between catchment areas by putative environmental risk factors. DESIGN, SETTING, AND PARTICIPANTS An international multisite incidence study (the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions) was conducted from May 1, 2010, to April 1, 2015, among 2774 individuals from England (2 catchment areas), France (3 catchment areas), Italy (3 catchment areas), the Netherlands (2 catchment areas), Spain (6 catchment areas), and Brazil (1 catchment area) with a first episode of nonorganic psychotic disorders (International Statistical Classification of Diseases and Related Health Problems, Tenth Revision [ICD-10] codes F20-F33) confirmed by the Operational Criteria Checklist. Denominator populations were estimated using official national statistics. EXPOSURES Age, sex, and racial/ethnic minority status were treated as a priori confounders. Latitude, population density, percentage unemployment, owner-occupied housing, and single-person households were treated as catchment area-level exposures. MAIN OUTCOMES AND MEASURES Incidence of nonorganic psychotic disorders (ICD-10 codes F20-F33), nonaffective psychoses (ICD-10 codes F20-F29), and affective psychoses (ICD-10 codes F30-F33) confirmed by the Operational Criteria Checklist. RESULTS A total of 2774 patients (1196 women and 1578 men; median age, 30.5 years [interquartile range, 23.0-41.0 years]) with incident cases of psychotic disorders were identified during 12.9 million person-years at risk (crude incidence, 21.4 per 100 000 person-years; 95%CI, 19.4-23.4 per 100 000 person-years). A total of 2183 patients (78.7%) had nonaffective psychotic disorders. After direct standardization for age, sex, and racial/ethnic minority status, an 8-fold variation was seen in the incidence of all psychotic disorders, from 6.0 (95%CI, 3.5-8.6) per 100 000 person-years in Santiago, Spain, to 46.1 (95%CI, 37.3-55.0) per 100 000 person-years in Paris, France. Rates were elevated in racial/ethnic minority groups (incidence rate ratio, 1.6; 95%CI, 1.5-1.7), were highest for men 18 to 24 years of age, and were lower in catchment areas with more owner-occupied homes (incidence rate ratio, 0.8; 95%CI, 0.7-0.8). Similar patterns were observed for nonaffective psychoses; a lower incidence of affective psychoses was associated with higher area-level unemployment (incidence rate ratio, 0.3; 95%CI, 0.2-0.5). CONCLUSIONS AND RELEVANCE This study confirmed marked heterogeneity in risk for psychotic disorders by person and place, including higher rates in younger men, racial/ethnic minorities, and areas characterized by a lower percentage of owner-occupied houses.
Published: 2018
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50. F114THE DEVELOPMENT OF THE MAUDSLEY ENVIRONMENTAL RISK SCORE FOR PSYCHOSIS

Author: Vassos, Evangelos, primary, Sham, Pak, additional, Kempton, Matthew, additional, Trotta, Antonella, additional, Stilo, Simona, additional, Gayer-Anderson, Charlotte, additional, Di Forti, Marta, additional, Lewis, Cathryn, additional, Murray, Robin, additional, and Morgan, Craig, additional
Published: 2019
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