21 results on '"Stinn B"'
Search Results
2. Sialolipom der Glandula parotis
- Author
-
Fritzsche, F.R., Bode, P.K., Stinn, B., Huber, G.F., and Noske, A.
- Published
- 2009
- Full Text
- View/download PDF
3. Die Computertomographie bei der Bildgebung von Kindern mit kongenitalen Herzvitien
- Author
-
Glaser-Gallion, N., Stinn, B., Alkadhi, H., Lell, M., Goo, H.W., Paul, J. -F, Wildermuth, S., Leschka, S., Glaser-Gallion, N., Stinn, B., Alkadhi, H., Lell, M., Goo, H.W., Paul, J. -F, Wildermuth, S., and Leschka, S.
- Abstract
Zusammenfassung: Kongenitale Herzfehler sind die häufigsten kongenitalen Fehlbildungen. Echokardiographie und Katheterangiographie gelten allgemein als Goldstandard zur Abklärung angeborener Herzerkrankungen. Die Magnetresonanztomographie ist aufgrund ihrer Fähigkeit, Herzvitien morphologisch und funktionell zu charakterisieren, als ein wichtiges ergänzendes Verfahren anzusehen. Durch mehr und mehr dosissparende Untersuchungsprotokolle der neuesten Gerätegenerationen und eine gleichzeitig bessere zeitliche und räumliche Auflösung findet die Computertomographie zunehmend Eingang in die Abklärung kongenitaler Herzfehler. In der präoperativen Planung und der postoperativen Kontrolle erlaubt sie eine übersichtliche Darstellung komplexer Fehlbildung nicht nur des Herzens, sondern auch der pulmonalvenösen und -arteriellen Zirkulation sowie des systemischen Kreislaufs. Dieser Beitrag gibt eine Übersicht über die technischen Aspekte der kardialen CT und die Anpassung des Untersuchungsprotokolls an die zu erwartende Pathologie und das Alter des Kindes. Zudem werden die Möglichkeiten und Limitationen der unterschiedlichen dosissparenden Protokolle erläutert
- Published
- 2018
4. Sialolipom der Glandula parotis
- Author
-
Fritzsche, F.R., Bode, P.K., Stinn, B., Huber, G.F., Noske, A., Fritzsche, F.R., Bode, P.K., Stinn, B., Huber, G.F., and Noske, A.
- Abstract
Zusammenfassung: Das Sialolipom ist eine relativ neue und seltene Lipomvariante der Speicheldrüsen, welche durch die Kombination von klassischer Lipommorphologie mit nichtneoplastischen duktuloazinären Speicheldrüsenanteilen gekennzeichnet ist. Inklusive des vorliegenden Falles wurden bislang 27Sialolipome publiziert, davon 14 in der Glandula parotis. Wir beschreiben die klinischen, radiologischen und pathomorphologischen Eigenschaften eines Sialolipoms der Ohrspeicheldrüse bei einem 43Jahre alten Patienten
- Published
- 2018
5. Kardiale Niedrigdosis-Computertomographie
- Author
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Karlo, Christoph, Stinn, B, Leschka, S, Alkadhi, H, Stolzmann, P, University of Zurich, and Karlo, Christoph
- Subjects
10042 Clinic for Diagnostic and Interventional Radiology ,610 Medicine & health ,2700 General Medicine ,General Medicine - Published
- 2010
- Full Text
- View/download PDF
6. Prediction model to estimate presence of coronary artery disease: Retrospective pooled analysis of existing cohorts
- Author
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Genders, T.S.S. (Tessa), Steyerberg, E.W. (Ewout), Hunink, M.G.M. (Myriam), Nieman, K. (Koen), Galema, T.W. (Tjebbe), Mollet, N.R.A. (Nico), Feyter, P.J. (Pim) de, Krestin, G.P. (Gabriel), Alkadhi, H. (Hatem), Leschka, S. (Sebastian), Desbiolles, L. (Lotus), Meijs, M.F.L. (Matthijs), Cramer, M.-J. (Maarten-Jan), Knuuti, J. (Juhani), Kajander, S. (Sami), Bogaert, J. (Jan), Goetschalckx, K. (Kaatje), Cademartiri, F. (Filippo), Maffei, E. (Erica), Martini, C. (Chiara), Seitun, S. (Sara), Aldrovandi, A. (Annachiara), Wildermuth, S. (Simon), Stinn, B. (Björn), Fornaro, J. (Jürgen), Feuchtner, G.M. (Gudrun), Zordo, T. (Tobias) de, Auer, T. (Thomas), Plank, F. (Fabian), Friedrich, G. (Guy), Pugliese, F. (Francesca), Petersen, S.E. (Steffen), Davies, L.C. (L. Ceri), Schoepf, U.J. (Joseph), Rowe, G.W. (Garrett W.), Mieghem, C.A.G. (Carlos) van, Driessche, L. (Luc) van, Sinitsyn, V. (Valentin), Gopalan, D. (Deepa), Nikolaou, K. (Konstantin), Bamberg, F. (Fabian), Cury, R.C. (Ricardo), Battle, J. (Juan), Maurovich-Horvat, P. (Pal), Bartykowszki, A. (Andrea), Merkely, B. (Bela), Becker, D. (Dávid), Hadamitzky, M. (Martin), Hausleiter, J. (Jörg), Dewey, T.M. (Todd M.), Zimmermann, E. (Elke), Laule, M. (Michael), Genders, T.S.S. (Tessa), Steyerberg, E.W. (Ewout), Hunink, M.G.M. (Myriam), Nieman, K. (Koen), Galema, T.W. (Tjebbe), Mollet, N.R.A. (Nico), Feyter, P.J. (Pim) de, Krestin, G.P. (Gabriel), Alkadhi, H. (Hatem), Leschka, S. (Sebastian), Desbiolles, L. (Lotus), Meijs, M.F.L. (Matthijs), Cramer, M.-J. (Maarten-Jan), Knuuti, J. (Juhani), Kajander, S. (Sami), Bogaert, J. (Jan), Goetschalckx, K. (Kaatje), Cademartiri, F. (Filippo), Maffei, E. (Erica), Martini, C. (Chiara), Seitun, S. (Sara), Aldrovandi, A. (Annachiara), Wildermuth, S. (Simon), Stinn, B. (Björn), Fornaro, J. (Jürgen), Feuchtner, G.M. (Gudrun), Zordo, T. (Tobias) de, Auer, T. (Thomas), Plank, F. (Fabian), Friedrich, G. (Guy), Pugliese, F. (Francesca), Petersen, S.E. (Steffen), Davies, L.C. (L. Ceri), Schoepf, U.J. (Joseph), Rowe, G.W. (Garrett W.), Mieghem, C.A.G. (Carlos) van, Driessche, L. (Luc) van, Sinitsyn, V. (Valentin), Gopalan, D. (Deepa), Nikolaou, K. (Konstantin), Bamberg, F. (Fabian), Cury, R.C. (Ricardo), Battle, J. (Juan), Maurovich-Horvat, P. (Pal), Bartykowszki, A. (Andrea), Merkely, B. (Bela), Becker, D. (Dávid), Hadamitzky, M. (Martin), Hausleiter, J. (Jörg), Dewey, T.M. (Todd M.), Zimmermann, E. (Elke), and Laule, M. (Michael)
- Published
- 2012
- Full Text
- View/download PDF
7. Prediction model to estimate presence of coronary artery disease: retrospective pooled analysis of existing cohorts
- Author
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Genders, Tessa, Steyerberg, Ewout, Nieman, Koen, Galema, Tjebbe, Mollet, Nico, Feijter, Pim, Krestin, Gabriel, Alkadhi, H, Leschka, S, Desbiolles, L, Meijs, MFL, Cramer, MJ, Knuuti, J, Kajander, S, Bogaert, J, Goetschalckx, K, Cademartiri, F., Maffei, E, Martini, C, Seitun, S, Aldrovandi, A, Wildermuth, S, Stinn, B, Fornaro, J, Feuchtner, G, De Zordo, T, Auer, T, Plank, F, Friedrich, G, Pugliese, F, Petersen, SE, Davies, LC, Schoepf, UJ, Rowe, GW, van Mieghem, CAG, van Driessche, L, Sinitsyn, V, Gopalan, D (Deepa), Nikolaou, K, Bamberg, F, Cury, RC, Battle, J, Maurovich-Horvat, P, Bartykowszki, A, Merkely, B, Becker, D, Hadamitzky, M, Hausleiter, J, Dewey, M, Zimmermann, E, Laule, M, Hunink, Myriam, Genders, Tessa, Steyerberg, Ewout, Nieman, Koen, Galema, Tjebbe, Mollet, Nico, Feijter, Pim, Krestin, Gabriel, Alkadhi, H, Leschka, S, Desbiolles, L, Meijs, MFL, Cramer, MJ, Knuuti, J, Kajander, S, Bogaert, J, Goetschalckx, K, Cademartiri, F., Maffei, E, Martini, C, Seitun, S, Aldrovandi, A, Wildermuth, S, Stinn, B, Fornaro, J, Feuchtner, G, De Zordo, T, Auer, T, Plank, F, Friedrich, G, Pugliese, F, Petersen, SE, Davies, LC, Schoepf, UJ, Rowe, GW, van Mieghem, CAG, van Driessche, L, Sinitsyn, V, Gopalan, D (Deepa), Nikolaou, K, Bamberg, F, Cury, RC, Battle, J, Maurovich-Horvat, P, Bartykowszki, A, Merkely, B, Becker, D, Hadamitzky, M, Hausleiter, J, Dewey, M, Zimmermann, E, Laule, M, and Hunink, Myriam
- Abstract
Objectives To develop prediction models that better estimate the pretest probability of coronary artery disease in low prevalence populations. Design Retrospective pooled analysis of individual patient data. Setting 18 hospitals in Europe and the United States. Participants Patients with stable chest pain without evidence for previous coronary artery disease, if they were referred for computed tomography (CT) based coronary angiography or catheter based coronary angiography (indicated as low and high prevalence settings, respectively). Main outcome measures Obstructive coronary artery disease (>= 50% diameter stenosis in at least one vessel found on catheter based coronary angiography). Multiple imputation accounted for missing predictors and outcomes, exploiting strong correlation between the two angiography procedures. Predictive models included a basic model (age, sex, symptoms, and setting), clinical model (basic model factors and diabetes, hypertension, dyslipidaemia, and smoking), and extended model (clinical model facto Results We included 5677 patients (3283 men, 2394 women), of whom 1634 had obstructive coronary artery disease found on catheter based coronary angiography. All potential predictors were significantly associated with the presence of disease in univariable and multivariable analyses. The clinical model improved the prediction, compared with the basic model (cross validated c statistic improvement from 0.77 to 0.79, net reclassification improvement 35%); the coronary calcium score in the extended Conclusions Updated prediction models including age, sex, symptoms, and cardiovascular risk factors allow for accurate estimation of the pretest probability of coronary artery disease in low prevalence populations. Addition of coronary calcium scores to the prediction models improves the estimates.
- Published
- 2012
8. Die Computertomographie bei der Bildgebung von Kindern mit kongenitalen Herzvitien
- Author
-
Glaser-Gallion, N, Stinn, B, Alkadhi, H, Lell, M, Goo, H W, Paul, J F, Wildermuth, S, Leschka, S, Glaser-Gallion, N, Stinn, B, Alkadhi, H, Lell, M, Goo, H W, Paul, J F, Wildermuth, S, and Leschka, S
- Abstract
Congenital heart diseases are the most common congenital abnormalities of development. In general, echocardiography and cardiac catheter angiography are considered the gold standard for the evaluation of congenital heart disease. Cardiac magnetic resonance imaging has become an important supplementary imaging modality because of its ability to provide an accurate morphological and functional evaluation. The role of cardiac computed tomography in the imaging of patients with congenital heart disease is becoming increasingly more important due to the development of low radiation dose protocols and improvements in the spatial and temporal resolution. In the preoperative depiction and follow-up after surgical repair of congenital heart diseases, cardiac computed tomography provides detailed information of the heart, the venous and arterial pulmonary circulation as well as systemic arteries. This article reviews the technical aspects of cardiac CT and the modification of examination protocols according to the expected pathology and patient age. The potentials and limitations of the various radiation dose reduction strategies are outlined.
- Published
- 2011
9. Technical principles of computed tomography in patients with congenital heart disease
- Author
-
Stinn, B, Stolzmann, P, Fornaro, J, Hibbeln, D, Alkadhi, H, Wildermuth, S, Leschka, S, Stinn, B, Stolzmann, P, Fornaro, J, Hibbeln, D, Alkadhi, H, Wildermuth, S, and Leschka, S
- Abstract
Cardiac magnetic resonance imaging and echocardiography are often the primary imaging techniques for many patients with congenital heart disease (CHD). However, with modern generations of CT systems and recent advances in temporal and spatial resolution, cardiac CT has been gaining an increasing reputation in the field of cardiac imaging and in the evaluation of patients with congenital heart disease. The CT imaging protocol depends on the suspected cardiac defect, the type of previous surgical repair, and the patient's age and level of cooperation. Various strategies are available for reducing radiation exposure, which is of utmost importance particularly in paediatric patients. A sequential segmental analysis is a commonly used approach to analysing congenital heart defects. Familiarity of the performing radiologist with dedicated CT protocols, the complex anatomy, morphology and terminology of CHD, as well as with the surgical procedures used to correct congenital abnormalities is a prerequisite for correct diagnosis.
- Published
- 2011
10. Low kilovoltage cardiac dual-source CT: attenuation, noise, and radiation dose
- Author
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Leschka, S, Stolzmann, P, Schmid, F T, Scheffel, H, Stinn, B, Marincek, B, Alkadhi, H, Wildermuth, S, Leschka, S, Stolzmann, P, Schmid, F T, Scheffel, H, Stinn, B, Marincek, B, Alkadhi, H, and Wildermuth, S
- Abstract
The purpose of this study was to investigate the effect of low kilovoltage dual-source computed tomography coronary angiography (CTCA) on qualitative and quantitative image quality parameters and radiation dose. Dual-source CTCA with retrospective ECG gating was performed in 80 consecutive patients of normal weight. Forty were examined with a standard protocol (120 kV/330mAs), 20 were examined at 100 kV/330mAs, and 20 at 100 kV/220mAs. Two blinded observers independently assessed image quality of each coronary segment and measured the image parameters noise, attenuation, and contrast-to-noise ratio (CNR). The effective radiation dose was calculated using CT dose volume index and the dose-length product. Diagnostic image quality was obtained in 99% of all coronary segments (1,127/1,140) without significant differences among the protocols. Image noise, attenuation, and CNR were significantly higher for 100 kV/330mAs (26 +/- 3 HU, 549 +/- 62 HU, 25.5 +/- 3.2; each P < 0.01) and 100 kV/220mAs (27 +/- 2 HU, 560 +/- 43 HU, 25.0 +/- 2.2; each P < 0.01) when compared to the 120-kV protocol (21 +/- 2 HU, 317 +/- 28 HU, 20.6 +/- 1.7). There was no significant difference between the two 100-kV protocols. Estimated effective radiation dose of the 120-kV protocol (8.9 +/- 1.2 mSv) was significantly higher than the 100 kV/330mAs (6.7 +/- 0.8 mSv, P < 0.01) or 100 kV/220mAs (4.4 +/- 0.6 mSv, P < 0.001) protocols. Dual-source CTCA with 100 kV is feasible in patients of normal weight, results in a diagnostic image quality with a higher CNR, and at the same time significantly reduces the radiation dose.
- Published
- 2008
11. Prediction model to estimate presence of coronary artery disease: retrospective pooled analysis of existing cohorts
- Author
-
Genders, T. S. S., primary, Steyerberg, E. W., additional, Hunink, M. G. M., additional, Nieman, K., additional, Galema, T. W., additional, Mollet, N. R., additional, Feyter, P. J. d., additional, Krestin, G. P., additional, Alkadhi, H., additional, Leschka, S., additional, Desbiolles, L., additional, Meijs, M. F. L., additional, Cramer, M. J., additional, Knuuti, J., additional, Kajander, S., additional, Bogaert, J., additional, Goetschalckx, K., additional, Cademartiri, F., additional, Maffei, E., additional, Martini, C., additional, Seitun, S., additional, Aldrovandi, A., additional, Wildermuth, S., additional, Stinn, B., additional, Fornaro, J., additional, Feuchtner, G., additional, De Zordo, T., additional, Auer, T., additional, Plank, F., additional, Friedrich, G., additional, Pugliese, F., additional, Petersen, S. E., additional, Davies, L. C., additional, Schoepf, U. J., additional, Rowe, G. W., additional, van Mieghem, C. A. G., additional, van Driessche, L., additional, Sinitsyn, V., additional, Gopalan, D., additional, Nikolaou, K., additional, Bamberg, F., additional, Cury, R. C., additional, Battle, J., additional, Maurovich-Horvat, P., additional, Bartykowszki, A., additional, Merkely, B., additional, Becker, D., additional, Hadamitzky, M., additional, Hausleiter, J., additional, Dewey, M., additional, Zimmermann, E., additional, and Laule, M., additional
- Published
- 2012
- Full Text
- View/download PDF
12. Die Computertomographie bei der Bildgebung von Kindern mit kongenitalen Herzvitien
- Author
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Glaser-Gallion, N., primary, Stinn, B., additional, Alkadhi, H., additional, Lell, M., additional, Goo, H.W., additional, Paul, J. -F., additional, Wildermuth, S., additional, and Leschka, S., additional
- Published
- 2010
- Full Text
- View/download PDF
13. Beurteilungsqualität von Koronararterien bei morbid adipösen Patienten: Vergleich von 64-Zeilen CT und Dual-Source CT
- Author
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Stinn, B, primary, Leschka, S, additional, Schmid, FT, additional, Schultes, B, additional, Thurnheer, M, additional, and Wildermuth, S, additional
- Published
- 2008
- Full Text
- View/download PDF
14. Kardiale Niedrigdosis-Computertomographie.
- Author
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Karlo, C., Stinn, B., Leschka, S., Alkadhi, H., and Stolzmann, P.
- Published
- 2010
- Full Text
- View/download PDF
15. Low kilovoltage cardiac dual-source CT: attenuation, noise, and radiation dose.
- Author
-
Leschka S, Stolzmann P, Schmid FT, Scheffel H, Stinn B, Marincek B, Alkadhi H, Wildermuth S, Leschka, Sebastian, Stolzmann, Paul, Schmid, Florian T, Scheffel, Hans, Stinn, Bjoern, Marincek, Borut, Alkadhi, Hatem, and Wildermuth, Simon
- Abstract
The purpose of this study was to investigate the effect of low kilovoltage dual-source computed tomography coronary angiography (CTCA) on qualitative and quantitative image quality parameters and radiation dose. Dual-source CTCA with retrospective ECG gating was performed in 80 consecutive patients of normal weight. Forty were examined with a standard protocol (120 kV/330mAs), 20 were examined at 100 kV/330mAs, and 20 at 100 kV/220mAs. Two blinded observers independently assessed image quality of each coronary segment and measured the image parameters noise, attenuation, and contrast-to-noise ratio (CNR). The effective radiation dose was calculated using CT dose volume index and the dose-length product. Diagnostic image quality was obtained in 99% of all coronary segments (1,127/1,140) without significant differences among the protocols. Image noise, attenuation, and CNR were significantly higher for 100 kV/330mAs (26 +/- 3 HU, 549 +/- 62 HU, 25.5 +/- 3.2; each P < 0.01) and 100 kV/220mAs (27 +/- 2 HU, 560 +/- 43 HU, 25.0 +/- 2.2; each P < 0.01) when compared to the 120-kV protocol (21 +/- 2 HU, 317 +/- 28 HU, 20.6 +/- 1.7). There was no significant difference between the two 100-kV protocols. Estimated effective radiation dose of the 120-kV protocol (8.9 +/- 1.2 mSv) was significantly higher than the 100 kV/330mAs (6.7 +/- 0.8 mSv, P < 0.01) or 100 kV/220mAs (4.4 +/- 0.6 mSv, P < 0.001) protocols. Dual-source CTCA with 100 kV is feasible in patients of normal weight, results in a diagnostic image quality with a higher CNR, and at the same time significantly reduces the radiation dose. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
16. Sialolipom der Glandula parotis
- Author
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Fritzsche, F.R., Bode, P.K., Stinn, B., Huber, G.F., Noske, A., Fritzsche, F.R., Bode, P.K., Stinn, B., Huber, G.F., and Noske, A.
- Abstract
Zusammenfassung: Das Sialolipom ist eine relativ neue und seltene Lipomvariante der Speicheldrüsen, welche durch die Kombination von klassischer Lipommorphologie mit nichtneoplastischen duktuloazinären Speicheldrüsenanteilen gekennzeichnet ist. Inklusive des vorliegenden Falles wurden bislang 27Sialolipome publiziert, davon 14 in der Glandula parotis. Wir beschreiben die klinischen, radiologischen und pathomorphologischen Eigenschaften eines Sialolipoms der Ohrspeicheldrüse bei einem 43Jahre alten Patienten
17. Die Computertomographie bei der Bildgebung von Kindern mit kongenitalen Herzvitien
- Author
-
Glaser-Gallion, N., Stinn, B., Alkadhi, H., Lell, M., Goo, H.W., Paul, J. -F, Wildermuth, S., Leschka, S., Glaser-Gallion, N., Stinn, B., Alkadhi, H., Lell, M., Goo, H.W., Paul, J. -F, Wildermuth, S., and Leschka, S.
- Abstract
Zusammenfassung: Kongenitale Herzfehler sind die häufigsten kongenitalen Fehlbildungen. Echokardiographie und Katheterangiographie gelten allgemein als Goldstandard zur Abklärung angeborener Herzerkrankungen. Die Magnetresonanztomographie ist aufgrund ihrer Fähigkeit, Herzvitien morphologisch und funktionell zu charakterisieren, als ein wichtiges ergänzendes Verfahren anzusehen. Durch mehr und mehr dosissparende Untersuchungsprotokolle der neuesten Gerätegenerationen und eine gleichzeitig bessere zeitliche und räumliche Auflösung findet die Computertomographie zunehmend Eingang in die Abklärung kongenitaler Herzfehler. In der präoperativen Planung und der postoperativen Kontrolle erlaubt sie eine übersichtliche Darstellung komplexer Fehlbildung nicht nur des Herzens, sondern auch der pulmonalvenösen und -arteriellen Zirkulation sowie des systemischen Kreislaufs. Dieser Beitrag gibt eine Übersicht über die technischen Aspekte der kardialen CT und die Anpassung des Untersuchungsprotokolls an die zu erwartende Pathologie und das Alter des Kindes. Zudem werden die Möglichkeiten und Limitationen der unterschiedlichen dosissparenden Protokolle erläutert
18. First-line treatment of NRAS-mutated metastatic melanoma with a MEK inhibitor.
- Author
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Bickel A, Diem S, Flatz L, Stinn B, and Siano M
- Subjects
- Aged, 80 and over, Humans, Male, Melanoma pathology, Neoplasm Metastasis, Skin Neoplasms pathology, Treatment Outcome, Azetidines therapeutic use, GTP Phosphohydrolases genetics, Melanoma drug therapy, Membrane Proteins genetics, Mitogen-Activated Protein Kinase Kinases antagonists & inhibitors, Mutation, Piperidines therapeutic use, Skin Neoplasms drug therapy
- Abstract
Until recently, standard treatment for advanced melanoma comprised basically dacarbazine and interleukin-2, leading to low response rates and significant toxicity. These days, new treatments such as immunotherapy (anti-CTLA4 and anti-PD1 antibodies) and targeted therapy with BRAF/MEK-inhibitor combinations for patients harboring a BRAF mutation are available. In BRAF wild-type patients harboring an NRAS mutation, not fit for immunotherapy treatment options are still dismal. We describe an 84-year-old patient with widespread metastatic melanoma. He presented in July 2015 with a cerebral hemorrhage under anticoagulation for atrial fibrillation. Computed tomography revealed extensive metastatic disease (liver, lung, bones, lymph nodes, heart, and brain). Molecular testing was negative for BRAF but showed the presence of an NRAS mutation in exon 3 (pQ61K [c.181C>A]). The patient received as first-line treatment two cycles of cobimetinib showing a good partial remission and manageable side effects., Competing Interests: None
- Published
- 2021
- Full Text
- View/download PDF
19. Technical principles of computed tomography in patients with congenital heart disease.
- Author
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Stinn B, Stolzmann P, Fornaro J, Hibbeln D, Alkadhi H, Wildermuth S, and Leschka S
- Abstract
Cardiac magnetic resonance imaging and echocardiography are often the primary imaging techniques for many patients with congenital heart disease (CHD). However, with modern generations of CT systems and recent advances in temporal and spatial resolution, cardiac CT has been gaining an increasing reputation in the field of cardiac imaging and in the evaluation of patients with congenital heart disease. The CT imaging protocol depends on the suspected cardiac defect, the type of previous surgical repair, and the patient's age and level of cooperation. Various strategies are available for reducing radiation exposure, which is of utmost importance particularly in paediatric patients. A sequential segmental analysis is a commonly used approach to analysing congenital heart defects. Familiarity of the performing radiologist with dedicated CT protocols, the complex anatomy, morphology and terminology of CHD, as well as with the surgical procedures used to correct congenital abnormalities is a prerequisite for correct diagnosis.
- Published
- 2011
- Full Text
- View/download PDF
20. Dual source CT coronary angiography in severely obese patients: trading off temporal resolution and image noise.
- Author
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Leschka S, Stinn B, Schmid F, Schultes B, Thurnheer M, Baumueller S, Stolzmann P, Scheffel H, Flohr TG, Wildermuth S, and Alkadhi H
- Subjects
- Adult, Aged, Coronary Artery Disease complications, Female, Humans, Obesity, Morbid complications, Radiographic Image Interpretation, Computer-Assisted methods, Reproducibility of Results, Sensitivity and Specificity, Artifacts, Coronary Angiography methods, Coronary Artery Disease diagnostic imaging, Obesity, Morbid diagnostic imaging, Radiographic Image Enhancement methods, Tomography, X-Ray Computed methods
- Abstract
Objective: To assess in severely obese patients the subjective and objective image quality parameters and to estimate the radiation dose of dual-source computed tomography coronary angiography (CTCA), using 3 different protocols., Materials and Methods: Dual-source CTCA was performed in 60 patients (30 women; mean age 58 +/- 7 years) suffering from obesity class II or higher (body mass index [BMI] >35 kg/sq m). Twenty patients were examined with a standard CTCA protocol at 120 kV/350 mAs (protocol A), 20 patients with a CTCA protocol at 140 kV/350 mAs (protocol B), and 20 patients at 140 kV/350 mAs with a dedicated obesity protocol (protocol C), that allows the additional data sampling by expanding the data acquisition for each tube from a quarter to a half rotation, permitting to trade off temporal resolution and image noise. Two blinded observers independently assessed the image quality of each coronary segment, using a 4-point scale (1: excellent-4: nondiagnostic) and measured the different image parameters (image noise, signal-to-noise ratio [SNR], and contrast-to-noise ratio [CNR]). Radiation dose estimates were calculated., Results: The average BMI was 46.3 +/- 8.3 kg/sq m (range, 36.8-69.6 kg/sq m). Subjective image quality (1.55 +/- 0.73) was significantly better in protocol C when compared with protocol A (2.46 +/- 0.76; P < 0.01) and protocol B (2.12 +/- 0.87; P < 0.017). There was a significantly lower rate of coronary artery segments with nondiagnostic image quality when using the obesity protocol C (1.5%; 4/262) compared with that obtained when using protocol A (7.8%; 22/280; P < 0.01) and protocol B (4.4%; 12/275; P < 0.017). Image noise was significantly lower in protocol C (31.8 +/- 5.0 HU) when compared with group A (43.5 +/- 4.7 HU; P < 0.001) and B (36.8 +/- 5.5 HU; P < 0.01). SNR and CNR were significantly higher in group C (13.8 +/- 2.4 and 23.1 +/- 2.8) compared with group A (10.6 +/- 1.7 and 15.1 +/- 3.2; each P < 0.001) and group B (12.0 +/- 2.0 and 18.8 +/- 3.1; each P < 0.01). The estimated effective radiation dose of the obesity protocol C (15.6 +/- 0.9 mSv) was significantly higher when compared with that in protocol A (10.1 +/- 0.8 mSv; P < 0.01), but not significantly different from that in protocol B (13.3 +/- 0.8 mSv; P = 0.022)., Conclusions: Use of an obesity protocol in dual-source CTCA in severely obese patients significantly improves image quality, but goes along with a higher radiation dose.
- Published
- 2009
- Full Text
- View/download PDF
21. Mono- versus bisegment reconstruction algorithms for dual-source computed tomography coronary angiography.
- Author
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Leschka S, Alkadhi H, Stolzmann P, Schmid FT, Leschka SC, Scheffel H, Stinn B, Flohr TG, Marincek B, and Wildermuth S
- Subjects
- Adult, Aged, Aged, 80 and over, Coronary Vessels pathology, Female, Humans, Image Enhancement instrumentation, Linear Models, Male, Middle Aged, Algorithms, Coronary Angiography instrumentation, Coronary Vessels physiology, Image Processing, Computer-Assisted instrumentation, Radiation Dosage, Tomography, X-Ray Computed instrumentation
- Abstract
Objective: To compare the image quality of mono- versus bisegment reconstruction algorithms for dual-source computed tomography coronary angiography (CTCA)., Materials and Methods: Eighty consecutive patients (27 women; average age, 60 +/- 12 years) were randomly assigned to 2 different CTCA scanning protocols: 40 patients (group A) underwent dual-source CTCA with a heart rate (HR)-dependent pitch adaptation with datasets reconstructed using the monosegment algorithm; 40 patients (group B) underwent CTCA at a fixed pitch of 0.2 and datasets were reconstructed using both mono- and bisegment algorithms. The temporal resolution was 82 milliseconds for mono- and 42 to 83 milliseconds (58 +/- 14 milliseconds) for bisegment reconstruction, the latter depending on the HR during CTCA. Images were reconstructed in the reconstruction phase having least motion artifacts in the individual patient, primarily during mid-diastole at 70% of the R-R interval. The HR variability was defined as the standard deviation from the average HR. Two blinded observers independently assessed the image quality of each coronary segment using a 4-point scale (1: excellent to 4: nonevaluable). Effective radiation dose estimates were calculated., Results: The overall image quality showed no significant differences between the 2 groups scanned with a fixed or a HR-adapted pitch (group A, score 1.21 +/- 0.63; group B, score 1.19 +/- 0.52). The overall image quality was superior when using monosegment (group A and B, score 1.21 +/- 0.63 and 1.19 +/- 0.52, respectively) when compared with the bisegment reconstruction algorithm (group B, score 1.33 +/- 0.72; P < 0.01). Image quality did not significantly correlate with average HR neither for monosegment (group A: r = 0.07; P = 0.35; group B: r = 0.06; P = 0.41) nor bisegment reconstructions (r = 0.07; P = 0.32). There was no significant correlation between image quality and HR variability using monosegment reconstructions (group A: r = 0.09; P = 0.22; group B: r = 0.05; P = 0.67), whereas a significant correlation was found for bisegment reconstructions (group B: r = 0.51; P < 0.01). The estimated effective radiation dose was significantly higher in group B (10.8 +/- 1.4 mSv) when compared with group A (9.0 +/- 0.8 mSv; P < 0.01)., Conclusions: Although providing a higher temporal resolution at certain HRs, the use of bisegment reconstructions for dual-source CTCA does not result in an improved overall image quality when compared with the monosegment reconstruction algorithm.
- Published
- 2008
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