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162 results on '"Stoecklein, Sophia"'

1. Preserved prenatal lung growth assessed by fetal MRI in the omicron-dominated phase of the SARS-CoV-2 pandemic

Author

Biechele, Gloria, Koliogiannis, Vanessa, Rennollet, Philippe, Prester, Tobias, Schulz, Enrico, Kolben, Thomas, Jegen, Magdalena, Hübener, Christoph, Hasbargen, Uwe, Flemmer, Andreas, Dietrich, Olaf, Burkard, Tanja, Schinner, Regina, Dinkel, Julien, Muenchhoff, Maximilian, Hintz, Susan, Delius, Maria, Mahner, Sven, Ricke, Jens, Hilgendorff, Anne, and Stoecklein, Sophia

Published
2024
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2. Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease

Author

Zatcepin, Artem, Gnörich, Johannes, Rauchmann, Boris-Stephan, Bartos, Laura M., Wagner, Stephan, Franzmeier, Nicolai, Malpetti, Maura, Xiang, Xianyuan, Shi, Yuan, Parhizkar, Samira, Grosch, Maximilian, Wind-Mark, Karin, Kunte, Sebastian T., Beyer, Leonie, Meyer, Carolin, Brösamle, Desirée, Wendeln, Ann-Christin, Osei-Sarpong, Collins, Heindl, Steffanie, Liesz, Arthur, Stoecklein, Sophia, Biechele, Gloria, Finze, Anika, Eckenweber, Florian, Lindner, Simon, Rominger, Axel, Bartenstein, Peter, Willem, Michael, Tahirovic, Sabina, Herms, Jochen, Buerger, Katharina, Simons, Mikael, Haass, Christian, Rupprecht, Rainer, Riemenschneider, Markus J., Albert, Nathalie L., Beyer, Marc, Neher, Jonas J., Paeger, Lars, Levin, Johannes, Höglinger, Günter U., Perneczky, Robert, Ziegler, Sibylle I., and Brendel, Matthias

Published
2024
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4. Associations between sex, body mass index and the individual microglial response in Alzheimer’s disease

Author

Biechele, Gloria, Rauchmann, Boris-Stephan, Janowitz, Daniel, Buerger, Katharina, Franzmeier, Nicolai, Weidinger, Endy, Guersel, Selim, Schuster, Sebastian, Finze, Anika, Harris, Stefanie, Lindner, Simon, Albert, Nathalie L., Wetzel, Christian, Rupprecht, Rainer, Rominger, Axel, Palleis, Carla, Katzdobler, Sabrina, Burow, Lena, Kurz, Carolin, Zaganjori, Mirlind, Trappmann, Lena-Katharina, Goldhardt, Oliver, Grimmer, Timo, Haeckert, Jan, Keeser, Daniel, Stoecklein, Sophia, Morenas-Rodriguez, Estrella, Bartenstein, Peter, Levin, Johannes, Höglinger, Günter U., Simons, Mikael, Perneczky, Robert, and Brendel, Matthias

Published
2024
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5. Prognostic validation of a new classification system for extent of resection in glioblastoma: A report of the RANO resect group

Author

Karschnia, Philipp, Young, Jacob S, Dono, Antonio, Häni, Levin, Sciortino, Tommaso, Bruno, Francesco, Juenger, Stephanie T, Teske, Nico, Morshed, Ramin A, Haddad, Alexander F, Zhang, Yalan, Stoecklein, Sophia, Weller, Michael, Vogelbaum, Michael A, Beck, Juergen, Tandon, Nitin, Hervey-Jumper, Shawn, Molinaro, Annette M, Rudà, Roberta, Bello, Lorenzo, Schnell, Oliver, Esquenazi, Yoshua, Ruge, Maximilian I, Grau, Stefan J, Berger, Mitchel S, Chang, Susan M, van den Bent, Martin, and Tonn, Joerg-Christian

Subjects
Brain Disorders, Rare Diseases, Brain Cancer, Cancer, Neurosciences, Humans, Prognosis, Glioblastoma, Retrospective Studies, Brain Neoplasms, Neurosurgical Procedures, Treatment Outcome, EOR, classification, glioblastoma, outcome, surgical resection, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundTerminology to describe extent of resection in glioblastoma is inconsistent across clinical trials. A surgical classification system was previously proposed based upon residual contrast-enhancing (CE) tumor. We aimed to (1) explore the prognostic utility of the classification system and (2) define how much removed non-CE tumor translates into a survival benefit.MethodsThe international RANO resect group retrospectively searched previously compiled databases from 7 neuro-oncological centers in the USA and Europe for patients with newly diagnosed glioblastoma per WHO 2021 classification. Clinical and volumetric information from pre- and postoperative MRI were collected.ResultsWe collected 1,008 patients with newly diagnosed IDHwt glioblastoma. 744 IDHwt glioblastomas were treated with radiochemotherapy per EORTC-26981/22981 (TMZ/RT→TMZ) following surgery. Among these homogenously treated patients, lower absolute residual tumor volumes (in cm3) were favorably associated with outcome: patients with "maximal CE resection" (class 2) had superior outcome compared to patients with "submaximal CE resection" (class 3) or "biopsy" (class 4). Extensive resection of non-CE tumor (≤5 cm3 residual non-CE tumor) was associated with better survival among patients with complete CE resection, thus defining class 1 ("supramaximal CE resection"). The prognostic value of the resection classes was retained on multivariate analysis when adjusting for molecular and clinical markers.ConclusionsThe proposed "RANO categories for extent of resection in glioblastoma" are highly prognostic and may serve for stratification within clinical trials. Removal of non-CE tumor beyond the CE tumor borders may translate into additional survival benefit, providing a rationale to explicitly denominate such "supramaximal CE resection."

Published
2023

6. Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies

Author

Finze, Anika, Biechele, Gloria, Rauchmann, Boris-Stephan, Franzmeier, Nicolai, Palleis, Carla, Katzdobler, Sabrina, Weidinger, Endy, Guersel, Selim, Schuster, Sebastian, Harris, Stefanie, Schmitt, Julia, Beyer, Leonie, Gnörich, Johannes, Lindner, Simon, Albert, Nathalie L., Wetzel, Christian H., Rupprecht, Rainer, Rominger, Axel, Danek, Adrian, Burow, Lena, Kurz, Carolin, Tato, Maia, Utecht, Julia, Papazov, Boris, Zaganjori, Mirlind, Trappmann, Lena-Katharina, Goldhardt, Oliver, Grimmer, Timo, Haeckert, Jan, Janowitz, Daniel, Buerger, Katharina, Keeser, Daniel, Stoecklein, Sophia, Dietrich, Olaf, Morenas-Rodriguez, Estrella, Barthel, Henryk, Sabri, Osama, Bartenstein, Peter, Simons, Mikael, Haass, Christian, Höglinger, Günter U., Levin, Johannes, Perneczky, Robert, and Brendel, Matthias

Published
2023
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7. [18F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data

Author

Ballweg, Anna, Klaus, Carolin, Vogler, Letizia, Katzdobler, Sabrina, Wind, Karin, Zatcepin, Artem, Ziegler, Sibylle I., Secgin, Birkan, Eckenweber, Florian, Bohr, Bernd, Bernhardt, Alexander, Fietzek, Urban, Rauchmann, Boris-Stephan, Stoecklein, Sophia, Quach, Stefanie, Beyer, Leonie, Scheifele, Maximilian, Simmet, Marcel, Joseph, Emanuel, Lindner, Simon, Berg, Isabella, Koglin, Norman, Mueller, Andre, Stephens, Andrew W., Bartenstein, Peter, Tonn, Joerg C., Albert, Nathalie L., Kümpfel, Tania, Kerschensteiner, Martin, Perneczky, Robert, Levin, Johannes, Paeger, Lars, Herms, Jochen, and Brendel, Matthias

Published
2023
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11. Association between aerobic fitness and the functional connectome in patients with schizophrenia

Author

Roell, Lukas, Maurus, Isabel, Keeser, Daniel, Karali, Temmuz, Papazov, Boris, Hasan, Alkomiet, Schmitt, Andrea, Papazova, Irina, Lembeck, Moritz, Hirjak, Dusan, Sykorova, Eliska, Thieme, Cristina E., Muenz, Susanne, Seitz, Valentina, Greska, David, Campana, Mattia, Wagner, Elias, Loehrs, Lisa, Stoecklein, Sophia, Ertl-Wagner, Birgit, Poemsl, Johannes, Roeh, Astrid, Malchow, Berend, Keller-Varady, Katriona, Meyer-Lindenberg, Andreas, and Falkai, Peter

Published
2022
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12. Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease

Author

Ersoezlue, Ersin, Rauchmann, Boris-Stephan, Schneider-Axmann, Thomas, Wagner, Michael, Ballarini, Tommaso, Tato, Maia, Utecht, Julia, Kurz, Carolin, Papazov, Boris, Guersel, Selim, Burow, Lena, Koller, Gabriele, Stöcklein, Sophia, Keeser, Daniel, Bartels, Claudia, Brosseron, Frederic, Buerger, Katharina, Cetindag, Arda C., Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Frommann, Ingo, Haynes, John D., Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Kleinedam, Luca, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Peters, Oliver, Preis, Lukas, Priller, Josef, Ramirez, Alfredo, Roeske, Sandra, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike J., Teipel, Stefan, Wiltfang, Jens, Wolfsgruber, Steffen, Yakupov, Renat, Duezel, Emrah, Jessen, Frank, and Perneczky, Robert

Published
2023
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14. Subcortical tau is linked to hypoperfusion in connected cortical regions in 4-repeat tauopathies

Author

Roemer, Sebastian N, primary, Brendel, Matthias, additional, Gnoerich, Johannes, additional, Malpetti, Maura, additional, Zaganjori, Mirlind, additional, Quattrone, Andrea, additional, Gross, Mattes, additional, Steward, Anna, additional, Dewenter, Anna, additional, Wagner, Fabian, additional, Dehsarvi, Amir, additional, Ferschmann, Christian, additional, Wall, Stephan, additional, Palleis, Carla, additional, Rauchmann, Boris S, additional, Katzdobler, Sabrina, additional, Jaeck, Alexander, additional, Stockbauer, Anna, additional, Fietzek, Urban M, additional, Bernhardt, Alexander M, additional, Weidinger, Endy, additional, Zwergal, Andreas, additional, Stoecklein, Sophia, additional, Perneczky, Robert, additional, Barthel, Henryk, additional, Sabri, Osama, additional, Levin, Johannes, additional, Hoeglinger, Guenter U, additional, and Franzmeier, Nicolai, additional

Published
2024
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16. The spine-brain axis: is spinal anatomy associated with brain volume?

Author

Grosu, Sergio, Nikolova, Trayana, Lorbeer, Roberto, Stoecklein, Veit M, Rospleszcz, Susanne, Fink, Nicola, Schlett, Christopher L, Storz, Corinna, Beller, Ebba, Keeser, Daniel, Heier, Margit, Kiefer, Lena S, Maurer, Elke, Walter, Sven S, Ertl-Wagner, Birgit B, Ricke, Jens, Bamberg, Fabian, Peters, Annette, and Stoecklein, Sophia

Published
2024
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19. Association between Long-Term Exposure to Traffic-Related Air Pollution and Cardio-Metabolic Phenotypes: An MRI Data-Based Analysis

Author

Woeckel, Margarethe, Rospleszcz, Susanne, Wolf, Kathrin, Breitner-Busch, Susanne, Ingrisch, Michael, Bamberg, Fabian, Ricke, Jens, Schlett, Christopher L, Storz, Corinna, Schneider, Alexandra, Stoecklein, Sophia, and Peters, Annette

Abstract

Long-term exposure to traffic-related air pollution (TRAP) is associated with cardiometabolic disease; however, its role in subclinical stages of disease development is unclear. Thus, we aimed to explore this association in a cross-sectional analysis, with cardiometabolic phenotypes derived from magnetic resonance imaging (MRI). Phenotypes of the left (LV) and right cardiac ventricle, whole-body adipose tissue (AT), and organ-specific AT were obtained by MRI in 400 participants of the KORA cohort. Land-use regression models were used to estimate residential long-term exposures to TRAP, e.g., nitrogen dioxides (NO2) or particle number concentration (PNC). Associations between TRAP and MRI phenotypes were modeled using linear regression. Participants’ mean age was 56 ± 9 years, and 42% were female. Long-term exposure to TRAP was associated with decreased LV wall thickness; a 6.0 μg/m3increase in NO2was associated with a −1.9% [95% confidence interval: −3.7%; −0.1%] decrease in mean global LV wall thickness. Furthermore, we found associations between TRAP and increased cardiac AT. A 2,242 n/cm3increase in PNC was associated with a 4.3% [−1.7%; 10.4%] increase in mean total cardiac AT. Associations were more pronounced in women and in participants with diabetes. Our exploratory study indicates that long-term exposure to TRAP is associated with subclinical cardiometabolic disease states, particularly in metabolically vulnerable subgroups.

Published
2024
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20. Delineating morbidity patterns in preterm infants at near-term age using a data-driven approach

Author

Ciora, Octavia-Andreea; https://orcid.org/0000-0002-9399-781X, Seegmüller, Tanja, Fischer, Johannes S; https://orcid.org/0000-0001-9504-3844, Wirth, Theresa, Häfner, Friederike; https://orcid.org/0000-0003-1488-6490, Stoecklein, Sophia, Flemmer, Andreas W, Förster, Kai; https://orcid.org/0000-0002-4127-1400, Kindt, Alida; https://orcid.org/0000-0001-6551-6030, Bassler, Dirk, Poets, Christian F, Ahmidi, Narges; https://orcid.org/0000-0003-0983-9964, Hilgendorff, Anne; https://orcid.org/0000-0002-3725-996X, Ciora, Octavia-Andreea; https://orcid.org/0000-0002-9399-781X, Seegmüller, Tanja, Fischer, Johannes S; https://orcid.org/0000-0001-9504-3844, Wirth, Theresa, Häfner, Friederike; https://orcid.org/0000-0003-1488-6490, Stoecklein, Sophia, Flemmer, Andreas W, Förster, Kai; https://orcid.org/0000-0002-4127-1400, Kindt, Alida; https://orcid.org/0000-0001-6551-6030, Bassler, Dirk, Poets, Christian F, Ahmidi, Narges; https://orcid.org/0000-0003-0983-9964, and Hilgendorff, Anne; https://orcid.org/0000-0002-3725-996X

Abstract

BACKGROUND: Long-term survival after premature birth is significantly determined by development of morbidities, primarily affecting the cardio-respiratory or central nervous system. Existing studies are limited to pairwise morbidity associations, thereby lacking a holistic understanding of morbidity co-occurrence and respective risk profiles. METHODS: Our study, for the first time, aimed at delineating and characterizing morbidity profiles at near-term age and investigated the most prevalent morbidities in preterm infants: bronchopulmonary dysplasia (BPD), pulmonary hypertension (PH), mild cardiac defects, perinatal brain pathology and retinopathy of prematurity (ROP). For analysis, we employed two independent, prospective cohorts, comprising a total of 530 very preterm infants: AIRR ("Attention to Infants at Respiratory Risks") and NEuroSIS ("Neonatal European Study of Inhaled Steroids"). Using a data-driven strategy, we successfully characterized morbidity profiles of preterm infants in a stepwise approach and (1) quantified pairwise morbidity correlations, (2) assessed the discriminatory power of BPD (complemented by imaging-based structural and functional lung phenotyping) in relation to these morbidities, (3) investigated collective co-occurrence patterns, and (4) identified infant subgroups who share similar morbidity profiles using machine learning techniques. RESULTS: First, we showed that, in line with pathophysiologic understanding, BPD and ROP have the highest pairwise correlation, followed by BPD and PH as well as BPD and mild cardiac defects. Second, we revealed that BPD exhibits only limited capacity in discriminating morbidity occurrence, despite its prevalence and clinical indication as a driver of comorbidities. Further, we demonstrated that structural and functional lung phenotyping did not exhibit higher association with morbidity severity than BPD. Lastly, we identified patient clusters that share similar morbidity patterns using machine learning

Published
2024

26. Associations between sex, body mass index and the individual microglial response in Alzheimer’s disease

Author

Biechele, Gloria, primary, Rauchmann, Boris-Stephan, additional, Janowitz, Daniel, additional, Buerger, Katharina, additional, Franzmeier, Nicolai, additional, Weidinger, Endy, additional, Guersel, Selim, additional, Schuster, Sebastian, additional, Finze, Anika, additional, Harris, Stefanie, additional, Lindner, Simon, additional, Albert, Nathalie L., additional, Wetzel, Christian, additional, Rupprecht, Rainer, additional, Rominger, Axel, additional, Palleis, Carla, additional, Katzdobler, Sabrina, additional, Burow, Lena, additional, Kurz, Carolin, additional, Zaganjori, Mirlind, additional, Trappmann, Lena-Katharina, additional, Goldhardt, Oliver, additional, Grimmer, Timo, additional, Haeckert, Jan, additional, Keeser, Daniel, additional, Stoecklein, Sophia, additional, Morenas-Rodriguez, Estrella, additional, Bartenstein, Peter, additional, Levin, Johannes, additional, Höglinger, Günter U., additional, Simons, Mikael, additional, Perneczky, Robert, additional, and Brendel, Matthias, additional

Published
2023
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27. Functional connectivity MRI provides an imaging correlate for CAR T cell associated neurotoxicity

Author

Stoecklein, Sophia, primary, Wunderlich, Stephan, additional, Papazov, Boris, additional, Winkelmann, Michael, additional, Kunz, Wolfgang G, additional, Mueller, Katharina, additional, Ernst, Katharina, additional, Stoecklein, Veit M, additional, Blumenberg, Viktoria, additional, Karschnia, Philipp, additional, Bücklein, Veit L, additional, Rejeski, Kai, additional, Schmidt, Christian, additional, von Bergwelt-Baildon, Michael, additional, Tonn, Joerg-Christian, additional, Ricke, Jens, additional, Liu, Hesheng, additional, Remi, Jan, additional, Subklewe, Marion, additional, von Baumgarten, Louisa, additional, and Schoeberl, Florian, additional

Published
2023
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28. MRI pulmonary artery flow detects lung vascular pathology in preterms with lung disease

Author

Häfner, Friederike, primary, Kindt, Alida, additional, Strobl, Kathrin, additional, Förster, Kai, additional, Heydarian, Motaharehsadat, additional, Gonzalez, Erika, additional, Schubert, Benjamin, additional, Kraus, Yvonne, additional, Dalla Pozza, Robert, additional, Flemmer, Andreas W., additional, Ertl-Wagner, Birgit, additional, Dietrich, Olaf, additional, Stoecklein, Sophia, additional, Tello, Khodr, additional, and Hilgendorff, Anne, additional

Published
2023
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29. Strong Association of Depression and Anxiety With the Presence of Back Pain While Impact of Spinal Imaging Findings is Limited: Analysis of an MRI Cohort Study

Author

Stoecklein, Veit M., primary, Grosu, Sergio, additional, Nikolova, Trayana, additional, Tonn, Joerg-Christian, additional, Zausinger, Stefan, additional, Ricke, Jens, additional, Schlett, Christopher L., additional, Maurer, Elke, additional, Walter, Sven S., additional, Peters, Annette, additional, Bamberg, Fabian, additional, Rospleszcz, Susanne, additional, and Stoecklein, Sophia, additional

Published
2023
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31. Effects of Exercise on Structural and Functional Brain Patterns in Schizophrenia—Data From a Multicenter Randomized-Controlled Study

Author

Roell, Lukas, primary, Keeser, Daniel, additional, Papazov, Boris, additional, Lembeck, Moritz, additional, Papazova, Irina, additional, Greska, David, additional, Muenz, Susanne, additional, Schneider-Axmann, Thomas, additional, Sykorova, Eliska B, additional, Thieme, Christina E, additional, Vogel, Bob O, additional, Mohnke, Sebastian, additional, Huppertz, Charlotte, additional, Roeh, Astrid, additional, Keller-Varady, Katriona, additional, Malchow, Berend, additional, Stoecklein, Sophia, additional, Ertl-Wagner, Birgit, additional, Henkel, Karsten, additional, Wolfarth, Bernd, additional, Tantchik, Wladimir, additional, Walter, Henrik, additional, Hirjak, Dusan, additional, Schmitt, Andrea, additional, Hasan, Alkomiet, additional, Meyer-Lindenberg, Andreas, additional, Falkai, Peter, additional, and Maurus, Isabel, additional

Published
2023
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33. Distributed changes of the functional connectome in patients with glioblastoma

Author

Nenning, Karl-Heinz, Furtner, Julia, Kiesel, Barbara, Schwartz, Ernst, Roetzer, Thomas, Fortelny, Nikolaus, Bock, Christoph, Grisold, Anna, Marko, Martha, Leutmezer, Fritz, Liu, Hesheng, Golland, Polina, Stoecklein, Sophia, Hainfellner, Johannes A., Kasprian, Gregor, Prayer, Daniela, Marosi, Christine, Widhalm, Georg, Woehrer, Adelheid, and Langs, Georg

Published
2020
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35. Effects of Exercise on Structural and Functional Brain Patterns in Schizophrenia—Data From a Multicenter Randomized-Controlled Study.

Author

Roell, Lukas, Keeser, Daniel, Papazov, Boris, Lembeck, Moritz, Papazova, Irina, Greska, David, Muenz, Susanne, Schneider-Axmann, Thomas, Sykorova, Eliska B, Thieme, Christina E, Vogel, Bob O, Mohnke, Sebastian, Huppertz, Charlotte, Roeh, Astrid, Keller-Varady, Katriona, Malchow, Berend, Stoecklein, Sophia, Ertl-Wagner, Birgit, Henkel, Karsten, and Wolfarth, Bernd

Subjects
BRAIN physiology, BRAIN anatomy, RESEARCH, AEROBIC exercises, SCHIZOPHRENIA, TREATMENT effectiveness, RANDOMIZED controlled trials, RESEARCH funding, PSYCHOLOGICAL adaptation, LOGISTIC regression analysis
Abstract

Background and Hypothesis Aerobic exercise interventions in people with schizophrenia have been demonstrated to improve clinical outcomes, but findings regarding the underlying neural mechanisms are limited and mainly focus on the hippocampal formation. Therefore, we conducted a global exploratory analysis of structural and functional neural adaptations after exercise and explored their clinical implications. Study Design In this randomized controlled trial, structural and functional MRI data were available for 91 patients with schizophrenia who performed either aerobic exercise on a bicycle ergometer or underwent a flexibility, strengthening, and balance training as control group. We analyzed clinical and neuroimaging data before and after 6 months of regular exercise. Bayesian linear mixed models and Bayesian logistic regressions were calculated to evaluate effects of exercise on multiple neural outcomes and their potential clinical relevance. Study Results Our results indicated that aerobic exercise in people with schizophrenia led to structural and functional adaptations mainly within the default-mode network, the cortico-striato-pallido-thalamo-cortical loop, and the cerebello-thalamo-cortical pathway. We further observed that volume increases in the right posterior cingulate gyrus as a central node of the default-mode network were linked to improvements in disorder severity. Conclusions These exploratory findings suggest a positive impact of aerobic exercise on 3 cerebral networks that are involved in the pathophysiology of schizophrenia. Clinical Trials Registration The underlying study of this manuscript was registered in the International Clinical Trials Database, ClinicalTrials.gov (NCT number: NCT03466112, https://clinicaltrials.gov/ct2/show/NCT03466112?term=NCT03466112&draw=2&rank=1) and in the German Clinical Trials Register (DRKS-ID: DRKS00009804). [ABSTRACT FROM AUTHOR]

Published
2024
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37. Prognostic validation of a new classification system for extent of resection in glioblastoma:A report of the RANO resect group

Author

Karschnia, Philipp, Young, Jacob S., Dono, Antonio, Haeni, Levin, Sciortino, Tommaso, Bruno, Francesco, Juenger, Stephanie T., Teske, Nico, Morshed, Ramin A., Haddad, Alexander F., Zhang, Yalan, Stoecklein, Sophia, Weller, Michael, Vogelbaum, Michael A., Beck, Juergen, Tandon, Nitin, Hervey-Jumper, Shawn, Molinaro, Annette M., Ruda, Roberta, Bello, Lorenzo, Schnell, Oliver, Esquenazi, Yoshua, Ruge, Maximilian, Grau, Stefan J., Berger, Mitchel S., Chang, Susan M., van den Bent, Martin, Tonn, Joerg-Christian, Karschnia, Philipp, Young, Jacob S., Dono, Antonio, Haeni, Levin, Sciortino, Tommaso, Bruno, Francesco, Juenger, Stephanie T., Teske, Nico, Morshed, Ramin A., Haddad, Alexander F., Zhang, Yalan, Stoecklein, Sophia, Weller, Michael, Vogelbaum, Michael A., Beck, Juergen, Tandon, Nitin, Hervey-Jumper, Shawn, Molinaro, Annette M., Ruda, Roberta, Bello, Lorenzo, Schnell, Oliver, Esquenazi, Yoshua, Ruge, Maximilian, Grau, Stefan J., Berger, Mitchel S., Chang, Susan M., van den Bent, Martin, and Tonn, Joerg-Christian

Abstract

Background Terminology to describe extent of resection in glioblastoma is inconsistent across clinical trials. A surgical classification system was previously proposed based upon residual contrast-enhancing (CE) tumor. We aimed to (1) explore the prognostic utility of the classification system and (2) define how much removed non-CE tumor translates into a survival benefit. Methods The international RANO resect group retrospectively searched previously compiled databases from 7 neuro-oncological centers in the USA and Europe for patients with newly diagnosed glioblastoma per WHO 2021 classification. Clinical and volumetric information from pre- and postoperative MRI were collected. Results We collected 1,008 patients with newly diagnosed IDHwt glioblastoma. 744 IDHwt glioblastomas were treated with radiochemotherapy per EORTC-26981/22981 (TMZ/RT -> TMZ) following surgery. Among these homogenously treated patients, lower absolute residual tumor volumes (in cm(3)) were favorably associated with outcome: patients with "maximal CE resection" (class 2) had superior outcome compared to patients with "submaximal CE resection" (class 3) or "biopsy" (class 4). Extensive resection of non-CE tumor (<= 5 cm(3) residual non-CE tumor) was associated with better survival among patients with complete CE resection, thus defining class 1 ("supramaximal CE resection"). The prognostic value of the resection classes was retained on multivariate analysis when adjusting for molecular and clinical markers. Conclusions The proposed "RANO categories for extent of resection in glioblastoma" are highly prognostic and may serve for stratification within clinical trials. Removal of non-CE tumor beyond the CE tumor borders may translate into additional survival benefit, providing a rationale to explicitly denominate such "supramaximal CE resection."

Published
2023

38. [18F]DED PET Imaging of Reactive Astrogliosis in Neurodegenerative Diseases: Preclinical Proof of Concept and First-in-Human Data

Author

Ballweg, Anna, primary, Klaus, Carolin, additional, Vogler, Letizia, additional, Katzdobler, Sabrina, additional, Wind, Karin, additional, Zatcepin, Artem, additional, Ziegler, Sibylle, additional, Secgin, Birkan, additional, Eckenweber, Florian, additional, Bohr, Bernd, additional, Bernhardt, Alexander, additional, Fietzek, Urban, additional, Rauchmann, Boris-Stephan, additional, Stoecklein, Sophia, additional, Quach, Stefanie, additional, Beyer, Leonie, additional, Scheifele, Maximilian, additional, Simmet, Marcel, additional, Joseph, Emanuel, additional, Lindner, Simon, additional, Berg, Isabella, additional, Koglin, Norman, additional, Mueller, Andre, additional, Stephens, Andrew, additional, Bartenstein, Peter, additional, Tonn, Joerg-Christian, additional, Albert, Nathalie, additional, Kümpfel, Tanja, additional, Kerschensteiner, Martin, additional, Perneczky, Robert, additional, Levin, Johannes, additional, Paeger, Lars, additional, Herms, Jochen, additional, and Brendel, Matthias, additional

Published
2022
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39. A Residual Marker of Cognitive Reserve Is Associated with Resting-State Intrinsic Functional Connectivity Along the Alzheimer's Disease Continuum

Author

Ersoezlue, Ersin, Perneczky, Robert, Keeser, Daniel, Papazov, Boris, Totzke, Marie, Ballarini, Tommaso, Brosseron, Frederic, Buerger, Katharina, Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Tato, Maia, Glanz, Wenzel, Haynes, John Dylan, Heneka, Michael T, Janowitz, Daniel, Kilimann, Ingo, Kleineidam, Luca, Laske, Christoph, Maier, Franziska, Munk, Matthias H, Peters, Oliver, Utecht, Julia, Priller, Josef, Ramirez, Alfredo, Roeske, Sandra, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Schott, Björn H, Spottke, Annika, Spruth, Eike J, Teipel, Stefan, Kurz, Carolin, Unterfeld, Chantal, Wagner, Michael, Wang, Xiao, Wiltfang, Jens, Wolfsgruber, Steffen, Yakupov, Renat, Duezel, Emrah, Jessen, Frank, Rauchmann, Boris-Stephan, group, DELCODE study, Häckert, Jan, Guersel, Selim, Burow, Lena, Koller, Gabriele, and Stoecklein, Sophia

Subjects
cognition, General Neuroscience, resting-state functional connectivity, General Medicine, cognitive reserve, Magnetic Resonance Imaging, Psychiatry and Mental health, Clinical Psychology, pathology [Alzheimer Disease], intrinsic network connectivity, Neural Pathways, Humans, functional MRI, ddc:610, Geriatrics and Gerontology, Nerve Net, diagnostic imaging [Brain], Alzheimer’s disease
Abstract

Background: Cognitive reserve (CR) explains inter-individual differences in the impact of the neurodegenerative burden on cognitive functioning. A residual model was proposed to estimate CR more accurately than previous measures. However, associations between residual CR markers (CRM) and functional connectivity (FC) remain unexplored. Objective: To explore the associations between the CRM and intrinsic network connectivity (INC) in resting-state networks along the neuropathological-continuum of Alzheimer’s disease (ADN). Methods: Three hundred eighteen participants from the DELCODE cohort were stratified using cerebrospinal fluid biomarkers according to the A(myloid-β)/T(au)/N(eurodegeneration) classification. CRM was calculated utilizing residuals obtained from a multilinear regression model predicting cognition from markers of disease burden. Using an independent component analysis in resting-state fMRI data, we measured INC of resting-state networks, i.e., default mode network (DMN), frontoparietal network (FPN), salience network (SAL), and dorsal attention network. The associations of INC with a composite memory score and CRM and the associations of CRM with the seed-to-voxel functional connectivity of memory-related were tested in general linear models. Results: CRM was positively associated with INC in the DMN in the entire cohort. The A+T+N+ group revealed an anti-correlation between the SAL and the DMN. Furthermore, CRM was positively associated with anti-correlation between memory-related regions in FPN and DMN in ADN and A+T/N+. Conclusion: Our results provide evidence that INC is associated with CRM in ADN defined as participants with amyloid pathology with or without cognitive symptoms, suggesting that the neural correlates of CR are mirrored in network FC in resting-state.

Published
2023

40. Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies

Author

Finze, Anika, primary, Biechele, Gloria, additional, Rauchmann, Boris-Stephan, additional, Franzmeier, Nicolai, additional, Palleis, Carla, additional, Katzdobler, Sabrina, additional, Weidinger, Endy, additional, Guersel, Selim, additional, Schuster, Sebastian, additional, Harris, Stefanie, additional, Schmitt, Julia, additional, Beyer, Leonie, additional, Gnörich, Johannes, additional, Lindner, Simon, additional, Albert, Nathalie L., additional, Wetzel, Christian, additional, Rupprecht, Rainer, additional, Rominger, Axel, additional, Danek, Adrian, additional, Burow, Lena, additional, Kurz, Carolin, additional, Tato, Maia, additional, Utecht, Julia, additional, Papazov, Boris, additional, Zaganjori, Mirlind, additional, Trappmann, Lena-Katharina, additional, Goldhardt, Oliver, additional, Grimmer, Timo, additional, Haeckert, Jan, additional, Janowitz, Daniel, additional, Buerger, Katharina, additional, Keeser, Daniel, additional, Stoecklein, Sophia, additional, Dietrich, Olaf, additional, Morenas-Rodriguez, Estrella, additional, Barthel, Henryk, additional, Sabri, Osama, additional, Bartenstein, Peter, additional, Simons, Mikael, additional, Haass, Christian, additional, Höglinger, Günter U., additional, Levin, Johannes, additional, Perneczky, Robert, additional, and Brendel, Matthias, additional

Published
2022
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41. Microglial Activation and Connectivity in Alzheimer Disease and Aging

Author

Rauchmann, Boris‐Stephan, primary, Brendel, Matthias, additional, Franzmeier, Nicolai, additional, Trappmann, Lena, additional, Zaganjori, Mirlind, additional, Ersoezlue, Ersin, additional, Morenas‐Rodriguez, Estrella, additional, Guersel, Selim, additional, Burow, Lena, additional, Kurz, Carolin, additional, Haeckert, Jan, additional, Tatò, Maia, additional, Utecht, Julia, additional, Papazov, Boris, additional, Pogarell, Oliver, additional, Janowitz, Daniel, additional, Buerger, Katharina, additional, Ewers, Michael, additional, Palleis, Carla, additional, Weidinger, Endy, additional, Biechele, Gloria, additional, Schuster, Sebastian, additional, Finze, Anika, additional, Eckenweber, Florian, additional, Rupprecht, Rainer, additional, Rominger, Axel, additional, Goldhardt, Oliver, additional, Grimmer, Timo, additional, Keeser, Daniel, additional, Stoecklein, Sophia, additional, Dietrich, Olaf, additional, Bartenstein, Peter, additional, Levin, Johannes, additional, Höglinger, Günter, additional, and Perneczky, Robert, additional

Published
2022
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42. Prognostic validation of a new classification system for extent of resection in glioblastoma: A report of the RANO resect group

Author

Karschnia, Philipp, primary, Young, Jacob S, additional, Dono, Antonio, additional, Häni, Levin, additional, Sciortino, Tommaso, additional, Bruno, Francesco, additional, Juenger, Stephanie T, additional, Teske, Nico, additional, Morshed, Ramin A, additional, Haddad, Alexander F, additional, Zhang, Yalan, additional, Stoecklein, Sophia, additional, Weller, Michael, additional, Vogelbaum, Michael A, additional, Beck, Juergen, additional, Tandon, Nitin, additional, Hervey-Jumper, Shawn, additional, Molinaro, Annette M, additional, Rudà, Roberta, additional, Bello, Lorenzo, additional, Schnell, Oliver, additional, Esquenazi, Yoshua, additional, Ruge, Maximilian I, additional, Grau, Stefan J, additional, Berger, Mitchel S, additional, Chang, Susan M, additional, van den Bent, Martin, additional, and Tonn, Joerg-Christian, additional

Published
2022
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43. Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease

Author

Ersoezlue, Ersin, Rauchmann, Boris-Stephan, Schneider-Axmann, Thomas, Wagner, Michael, Ballarini, Tommaso, Tato, Maia, Utecht, Julia, Kurz, Carolin, Papazov, Boris, Guersel, Selim, Burow, Lena, Koller, Gabriele, Stoecklein, Sophia, Keeser, Daniel, Bartels, Claudia, Brosseron, Frederic, Buerger, Katharina, Cetindag, Arda C., Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Frommann, Ingo, Haynes, John D., Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Kleinedam, Luca, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Peters, Oliver, Preis, Lukas, Priller, Josef, Ramirez, Alfredo, Roeske, Sandra, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike J., Teipel, Stefan, Wiltfang, Jens, Wolfsgruber, Steffen, Yakupov, Renat, Duezel, Emrah, Jessen, Frank, Perneczky, Robert, Ersoezlue, Ersin, Rauchmann, Boris-Stephan, Schneider-Axmann, Thomas, Wagner, Michael, Ballarini, Tommaso, Tato, Maia, Utecht, Julia, Kurz, Carolin, Papazov, Boris, Guersel, Selim, Burow, Lena, Koller, Gabriele, Stoecklein, Sophia, Keeser, Daniel, Bartels, Claudia, Brosseron, Frederic, Buerger, Katharina, Cetindag, Arda C., Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Frommann, Ingo, Haynes, John D., Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Kleinedam, Luca, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Peters, Oliver, Preis, Lukas, Priller, Josef, Ramirez, Alfredo, Roeske, Sandra, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike J., Teipel, Stefan, Wiltfang, Jens, Wolfsgruber, Steffen, Yakupov, Renat, Duezel, Emrah, Jessen, Frank, and Perneczky, Robert

Abstract

Alzheimer's disease (AD) is associated with alterations in functional connectivity (FC) of the brain. The FC underpinnings of CR, that is, lifelong experiences, are largely unknown. Resting-state FC and structural MRI were performed in 76 CSF amyloid-beta (A beta) negative healthy controls and 152 A beta positive individ-uals as an AD spectrum cohort (ADS; 55 with subjective cognitive decline, SCD; 52 with mild cognitive impairment; 45 with AD dementia). Following a region-of-interest (ROI) FC analysis, intrinsic network connectivity within the default-mode network (INC-DMN) and anti-correlation in INC between the DMN and dorsal attention network (DMN:DAN) were obtained as composite scores. CR was estimated by ed-ucation and Lifetime Experiences Questionnaire (LEQ). The association between INC-DMN and MEM was attenuated by higher LEQ scores in the entire ADS group, particularly in SCD. In ROI analyses, higher LEQ scores were associated with higher FC within the DMN in ADS group. INC-DMN remains relatively in-tact despite memory decline in individuals with higher lifetime activity estimates, supporting a role for functional networks in maintaining cognitive function in AD.(c) 2022 Elsevier Inc. All rights reserved.

Published
2022

44. TERT promotor status does not add prognostic information in IDH-wildtype glioblastomas fulfilling other diagnostic WHO criteria: A report of the RANO resect group

Author

Karschnia, Philipp, Young, Jacob S., Dono, Antonio, Hani, Levin, Juenger, Stephanie T., Sciortino, Tommaso, Bruno, Francesco, Teske, Nico, Morshed, Ramin A., Haddad, Alexander F., Zhang, Yalan, Stoecklein, Sophia, Vogelbaum, Michael A., Beck, Juergen, Tandon, Nitin, Hervey-Jumper, Shawn, Molinaro, Annette M., Ruda, Roberta, Bello, Lorenzo, Schnell, Oliver, Esquenazi, Yoshua, Ruge, Maximilian, I, Grau, Stefan J., van den Bent, Martin, Weller, Michael, Berger, Mitchel S., Chang, Susan M., Tonn, Joerg-Christian, Karschnia, Philipp, Young, Jacob S., Dono, Antonio, Hani, Levin, Juenger, Stephanie T., Sciortino, Tommaso, Bruno, Francesco, Teske, Nico, Morshed, Ramin A., Haddad, Alexander F., Zhang, Yalan, Stoecklein, Sophia, Vogelbaum, Michael A., Beck, Juergen, Tandon, Nitin, Hervey-Jumper, Shawn, Molinaro, Annette M., Ruda, Roberta, Bello, Lorenzo, Schnell, Oliver, Esquenazi, Yoshua, Ruge, Maximilian, I, Grau, Stefan J., van den Bent, Martin, Weller, Michael, Berger, Mitchel S., Chang, Susan M., and Tonn, Joerg-Christian

Published
2022

45. TERT promotor status does not add prognostic information in IDH-wildtype glioblastomas fulfilling other diagnostic WHO criteria:A report of the RANO resect group

Author

Karschnia, Philipp, Young, Jacob S., Dono, Antonio, Häni, Levin, Juenger, Stephanie T., Sciortino, Tommaso, Bruno, Francesco, Teske, Nico, Morshed, Ramin A., Haddad, Alexander F., Zhang, Yalan, Stoecklein, Sophia, Vogelbaum, Michael A., Beck, Juergen, Tandon, Nitin, Hervey-Jumper, Shawn, Molinaro, Annette M., Rudà, Roberta, Bello, Lorenzo, Schnell, Oliver, Esquenazi, Yoshua, Ruge, Maximilian I., Grau, Stefan J., Van Den Bent, Martin, Weller, Michael, Berger, Mitchel S., Chang, Susan M., Tonn, Joerg Christian, Karschnia, Philipp, Young, Jacob S., Dono, Antonio, Häni, Levin, Juenger, Stephanie T., Sciortino, Tommaso, Bruno, Francesco, Teske, Nico, Morshed, Ramin A., Haddad, Alexander F., Zhang, Yalan, Stoecklein, Sophia, Vogelbaum, Michael A., Beck, Juergen, Tandon, Nitin, Hervey-Jumper, Shawn, Molinaro, Annette M., Rudà, Roberta, Bello, Lorenzo, Schnell, Oliver, Esquenazi, Yoshua, Ruge, Maximilian I., Grau, Stefan J., Van Den Bent, Martin, Weller, Michael, Berger, Mitchel S., Chang, Susan M., and Tonn, Joerg Christian

Abstract

In IDH-wildtype glioblastomas which meet the histopathological or molecular diagnosis criteria, it remains unclear whether the presence of TERT promotor mutations provides additional prognostic information. Based on a multicenter cohort of 466 IDH-wildtype glioblastomas (including 396 with and 70 patients without TERT promotor mutations), we found that TERT promotor mutations were neither associated with progression-free survival nor overall survival. This held true in various treatment-based or molecular subgroups. This argues against standardized analysis for TERT promotor mutation status for the purpose of prognostic or therapeutic relevance in newly diagnosed IDH-wildtype glioblastoma that otherwise meets the histopathological and molecular diagnosis criteria.

Published
2022

46. Differences in electric field strength between clinical and non-clinical populations induced by prefrontal tDCS: A cross-diagnostic, individual MRI-based modeling study

Author

Mizutani-Tiebel, Yuki, Takahashi, Shun, Karali, Temmuz, Mezger, Eva, Bulubas, Lucia, Papazova, Irina, Dechantsreiter, Esther, Stoecklein, Sophia, Papazov, Boris, Thielscher, Axel, Padberg, Frank, Keeser, Daniel, Mizutani-Tiebel, Yuki, Takahashi, Shun, Karali, Temmuz, Mezger, Eva, Bulubas, Lucia, Papazova, Irina, Dechantsreiter, Esther, Stoecklein, Sophia, Papazov, Boris, Thielscher, Axel, Padberg, Frank, and Keeser, Daniel

Abstract

Introduction: Prefrontal cortex (PFC) regions are promising targets for therapeutic applications of non-invasive brain stimulation, e.g. transcranial direct current stimulation (tDCS), which has been proposed as a novel intervention for major depressive disorder (MDD) and negative symptoms of schizophrenia (SCZ). However, the effects of tDCS vary inter-individually, and dose–response relationships have not been established. Stimulation parameters are often tested in healthy subjects and transferred to clinical populations. The current study investigates the variability of individual MRI-based electric fields (e-fields) of standard bifrontal tDCS across individual subjects and diagnoses. Method: The study included 74 subjects, i.e. 25 patients with MDD, 24 patients with SCZ, and 25 healthy controls (HC). Individual e-fields of a common tDCS protocol (i.e. 2 mA stimulation intensity, bifrontal anode-F3/cathode-F4 montage) were modeled by two investigators using SimNIBS (2.0.1) based on structural MRI scans. Result: On a whole-brain level, the average e-field strength was significantly reduced in MDD and SCZ compared to HC, but MDD and SCZ did not differ significantly. Regions of interest (ROI) analysis for PFC subregions showed reduced e-fields in Sallet areas 8B and 9 for MDD and SCZ compared to HC, whereas there was again no difference between MDD and SCZ. Within groups, we generally observed high inter-individual variability of e-field intensities at a higher percentile of voxels. Conclusion: MRI-based e-field modeling revealed significant differences in e-field strengths between clinical and non-clinical populations in addition to a general inter-individual variability. These findings support the notion that dose–response relationships for tDCS cannot be simply transferred from healthy to clinical cohorts and need to be individually established for clinical groups. In this respect, MRI-based e-field modeling may

Published
2022

47. TERT promotor status does not add prognostic information in IDH-wildtype glioblastomas fulfilling other diagnostic WHO criteria: A report of the RANO resect group

Author

Karschnia, Philipp; https://orcid.org/0000-0002-1254-5310, Young, Jacob S, Dono, Antonio; https://orcid.org/0000-0002-8041-8399, Häni, Levin, Juenger, Stephanie T, Sciortino, Tommaso, Bruno, Francesco; https://orcid.org/0000-0001-8087-5293, Teske, Nico, Morshed, Ramin A, Haddad, Alexander F, Zhang, Yalan, Stoecklein, Sophia, Vogelbaum, Michael A, Beck, Juergen, Tandon, Nitin; https://orcid.org/0000-0002-2752-2365, Hervey-Jumper, Shawn, Molinaro, Annette M; https://orcid.org/0000-0002-9854-7404, Rudà, Roberta, Bello, Lorenzo, Schnell, Oliver, Esquenazi, Yoshua; https://orcid.org/0000-0002-9757-1453, Ruge, Maximilian I, Grau, Stefan J, van den Bent, Martin, Weller, Michael; https://orcid.org/0000-0002-1748-174X, Berger, Mitchel S; https://orcid.org/0000-0003-1983-4892, Chang, Susan M, Tonn, Joerg-Christian, Karschnia, Philipp; https://orcid.org/0000-0002-1254-5310, Young, Jacob S, Dono, Antonio; https://orcid.org/0000-0002-8041-8399, Häni, Levin, Juenger, Stephanie T, Sciortino, Tommaso, Bruno, Francesco; https://orcid.org/0000-0001-8087-5293, Teske, Nico, Morshed, Ramin A, Haddad, Alexander F, Zhang, Yalan, Stoecklein, Sophia, Vogelbaum, Michael A, Beck, Juergen, Tandon, Nitin; https://orcid.org/0000-0002-2752-2365, Hervey-Jumper, Shawn, Molinaro, Annette M; https://orcid.org/0000-0002-9854-7404, Rudà, Roberta, Bello, Lorenzo, Schnell, Oliver, Esquenazi, Yoshua; https://orcid.org/0000-0002-9757-1453, Ruge, Maximilian I, Grau, Stefan J, van den Bent, Martin, Weller, Michael; https://orcid.org/0000-0002-1748-174X, Berger, Mitchel S; https://orcid.org/0000-0003-1983-4892, Chang, Susan M, and Tonn, Joerg-Christian

Published
2022

48. [18F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data.

Author

Ballweg, Anna, Klaus, Carolin, Vogler, Letizia, Katzdobler, Sabrina, Wind, Karin, Zatcepin, Artem, Ziegler, Sibylle I., Secgin, Birkan, Eckenweber, Florian, Bohr, Bernd, Bernhardt, Alexander, Fietzek, Urban, Rauchmann, Boris-Stephan, Stoecklein, Sophia, Quach, Stefanie, Beyer, Leonie, Scheifele, Maximilian, Simmet, Marcel, Joseph, Emanuel, and Lindner, Simon

Subjects
POSITRON emission tomography, GLIAL fibrillary acidic protein, NEURODEGENERATION, GLIOSIS, ALZHEIMER'S disease
Abstract

Objectives: Reactive gliosis is a common pathological hallmark of CNS pathology resulting from neurodegeneration and neuroinflammation. In this study we investigate the capability of a novel monoamine oxidase B (MAO-B) PET ligand to monitor reactive astrogliosis in a transgenic mouse model of Alzheimer's disease (AD). Furthermore, we performed a pilot study in patients with a range of neurodegenerative and neuroinflammatory conditions. Methods: A cross-sectional cohort of 24 transgenic (PS2APP) and 25 wild-type mice (age range: 4.3–21.0 months) underwent 60 min dynamic [18F]fluorodeprenyl-D2 ([18F]F-DED), static 18 kDa translocator protein (TSPO, [18F]GE-180) and β-amyloid ([18F]florbetaben) PET imaging. Quantification was performed via image derived input function (IDIF, cardiac input), simplified non-invasive reference tissue modelling (SRTM2, DVR) and late-phase standardized uptake value ratios (SUVr). Immunohistochemical (IHC) analyses of glial fibrillary acidic protein (GFAP) and MAO-B were performed to validate PET imaging by gold standard assessments. Patients belonging to the Alzheimer's disease continuum (AD, n = 2), Parkinson's disease (PD, n = 2), multiple system atrophy (MSA, n = 2), autoimmune encephalitis (n = 1), oligodendroglioma (n = 1) and one healthy control underwent 60 min dynamic [18F]F-DED PET and the data were analyzed using equivalent quantification strategies. Results: We selected the cerebellum as a pseudo-reference region based on the immunohistochemical comparison of age-matched PS2APP and WT mice. Subsequent PET imaging revealed that PS2APP mice showed elevated hippocampal and thalamic [18F]F-DED DVR when compared to age-matched WT mice at 5 months (thalamus: + 4.3%; p = 0.048), 13 months (hippocampus: + 7.6%, p = 0.022) and 19 months (hippocampus: + 12.3%, p < 0.0001; thalamus: + 15.2%, p < 0.0001). Specific [18F]F-DED DVR increases of PS2APP mice occurred earlier when compared to signal alterations in TSPO and β-amyloid PET and [18F]F-DED DVR correlated with quantitative immunohistochemistry (hippocampus: R = 0.720, p < 0.001; thalamus: R = 0.727, p = 0.002). Preliminary experience in patients showed [18F]F-DED VT and SUVr patterns, matching the expected topology of reactive astrogliosis in neurodegenerative (MSA) and neuroinflammatory conditions, whereas the patient with oligodendroglioma and the healthy control indicated [18F]F-DED binding following the known physiological MAO-B expression in brain. Conclusions: [18F]F-DED PET imaging is a promising approach to assess reactive astrogliosis in AD mouse models and patients with neurological diseases. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Effects of SARS-CoV-2 on prenatal lung growth assessed by fetal MRI

Author

Stoecklein, Sophia, primary, Koliogiannis, Vanessa, additional, Prester, Tobias, additional, Kolben, Thomas, additional, Jegen, Magdalena, additional, Hübener, Christoph, additional, Hasbargen, Uwe, additional, Flemmer, Andreas, additional, Dietrich, Olaf, additional, Schinner, Regina, additional, Dinkel, Julien, additional, Fink, Nicola, additional, Muenchhoff, Maximilian, additional, Hintz, Susan, additional, Delius, Maria, additional, Mahner, Sven, additional, Ricke, Jens, additional, and Hilgendorff, Anne, additional

Published
2022
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50. MRI connectivity-based spread of microglial activation in early Alzheimer's disease

Author

Rauchmann, Boris-Stephan, primary, Brendel, Matthias, additional, Franzmeier, Nicolai, additional, Trappmann, Lena, additional, Zaganjori, Mirlind, additional, Morenas-Rodriguez, Estrella, additional, Guersel, Selim, additional, Burow, Lena, additional, Kurz, Carolin, additional, Haeckert, Jan, additional, Tato, Maia, additional, Utecht, Julia, additional, Papazov, Boris, additional, Pogarell, Oliver, additional, Janowitz, Daniel, additional, Buerger, Katharina, additional, Ewers, Michael, additional, Palleis, Carla, additional, Weidinger, Endy, additional, Biechele, Gloria, additional, Schuster, Sebastian, additional, Finze, Anika, additional, Eckenweber, Florian, additional, Rupprecht, Rainer, additional, Rominger, Axel, additional, Goldhardt, Oliver, additional, Grimmer, Timo, additional, Keeser, Daniel, additional, Stoecklein, Sophia, additional, Dietrich, Olaf, additional, Bartenstein, Peter, additional, Levin, Johannes, additional, Hoeglinger, Guenter, additional, and Perneczky, Robert, additional

Published
2022
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