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4. Additional file 2 of Use of routinely collected health data in randomised clinical trials: comparison of trial-specific death data in the BOSS trial with NHS Digital data

Author

Love, Sharon B., Kilanowski, Anna, Yorke-Edwards, Victoria, Old, Oliver, Barr, Hugh, Stokes, Clive, Kendall, Catherine, and Sydes, Matthew R.

Abstract

Additional file 2: Table A2. Disparities in dates of death between the datasets where death is reported from both sources. Description: Information on the differences between the dates of death in the two sources.

Published
2021
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5. Additional file 1 of Use of routinely collected health data in randomised clinical trials: comparison of trial-specific death data in the BOSS trial with NHS Digital data

Author

Love, Sharon B., Kilanowski, Anna, Yorke-Edwards, Victoria, Old, Oliver, Barr, Hugh, Stokes, Clive, Kendall, Catherine, and Sydes, Matthew R.

Abstract

Additional file 1: Table A1. Dates of data freeze dd-mmm-yyyy. Description: Table of dates of the data freeze for each data source.

Published
2021
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6. Additional file 3 of Use of routinely collected health data in randomised clinical trials: comparison of trial-specific death data in the BOSS trial with NHS Digital data

Author

Love, Sharon B., Kilanowski, Anna, Yorke-Edwards, Victoria, Old, Oliver, Barr, Hugh, Stokes, Clive, Kendall, Catherine, and Sydes, Matthew R.

Abstract

Additional file 3: Table A3. Check of death reporting prior data freeze. Description: Information on how close to the data freeze date deaths are reported.

Published
2021
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7. Additional file 4 of Use of routinely collected health data in randomised clinical trials: comparison of trial-specific death data in the BOSS trial with NHS Digital data

Author

Love, Sharon B., Kilanowski, Anna, Yorke-Edwards, Victoria, Old, Oliver, Barr, Hugh, Stokes, Clive, Kendall, Catherine, and Sydes, Matthew R.

Abstract

Additional file 4: Table A4. Guideline table for use of RCHD in the UK. Description: A possible table for the recording of comparisons of trial and RCHD.

Published
2021
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9. BowelScope: Accuracy of Detection Using Endocuff Optimisation of Mucosal Abnormalities (the B-ADENOMA Study): a multicentre, randomised controlled flexible sigmoidoscopy trial

Author

Rees, Colin J, primary, Brand, Andrew, additional, Ngu, Wee Sing, additional, Stokes, Clive, additional, Hoare, Zoe, additional, Totton, Nicola, additional, Bhandari, Pradeep, additional, Sharp, Linda, additional, Bastable, Alexandra, additional, Rutter, Matthew D, additional, Verma, Ajay Mark, additional, Lee, Thomas J, additional, and Walls, Martin, additional

Published
2020
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11. Acetic acid-guided biopsies in Barrett’s surveillance for neoplasia detection versus non-targeted biopsies (Seattle protocol): A feasibility study for a randomized tandem endoscopy trial. The ABBA study

Author

Chedgy, Fergus, additional, Fogg, Carole, additional, Kandiah, Kesavan, additional, Barr, Hugh, additional, Higgins, Bernard, additional, McCord, Mimi, additional, Dewey, Ann, additional, De Caestecker, John, additional, Gadeke, Lisa, additional, Stokes, Clive, additional, Poller, David, additional, Longcroft-Wheaton, Gaius, additional, and Bhandari, Pradeep, additional

Published
2018
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12. Barrett's oesophagus patients attending hospital: Baseline clinical, patient history and quality of life data from BOSS and AspECT

Author

Love, Sharon, primary, Reilly, Gavin, additional, Roberts, Corran, additional, Wise, Adelyn, additional, Moayyedi, Paul, additional, Foy, Chris, additional, Stokes, Clive, additional, De Caestecker, John, additional, Attwood, Stephen, additional, Watson, Peter, additional, Ang, Yeng, additional, Bhandiri, Pradeep, additional, Old, Oliver, additional, Hapeshi, Julie, additional, Penman, Ian, additional, Rodgers, Colin, additional, Edwards, Cathryn, additional, Monk, David, additional, Ragunath, Krish, additional, Morris, Danielle, additional, Johnston, David, additional, Barr, Hugh, additional, and Jankowski, Janusz, additional

Published
2016
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13. 566 BRIDE (Barrett's Randomised Intervention for Dysplasia by Endoscopy) -Results of a Feasibility Study Comparing Argon Plasma Coagulation (APC) With Radiofrequency Ablation (RFA) After Endoscopic Resection of Patients With High Grade Dysplasia or T1 Adenocarcinoma in Barrett's Esophagus

Author

Peerally, Mohammad F., primary, Barr, Hugh, additional, Lovat, Laurence, additional, Bhandari, Pradeep, additional, Ragunath, Krish, additional, Smart, Howard, additional, Harrison, Rebecca, additional, Stokes, Clive, additional, and de Caestecker, John S., additional

Published
2016
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16. Barrett's Oesophagus Surveillance versus endoscopy at need Study (BOSS): protocol and analysis plan for a multicentre randomized controlled trial.

Author

Old, Oliver, Moayyedi, Paul, Love, Sharon, Roberts, Corran, Hapeshi, Julie, Foy, Chris, Stokes, Clive, Briggs, Andrew, Jankowski, Janusz, and Barr, Hugh

Subjects
ADENOCARCINOMA, BARRETT'S esophagus, ESOPHAGEAL tumors, ENDOSCOPY, GASTROESOPHAGEAL reflux, MEDICAL cooperation, RESEARCH, RANDOMIZED controlled trials, ENDOSCOPIC gastrointestinal surgery, EARLY detection of cancer, DISEASE complications, DIAGNOSIS
Abstract

Objectives: The absolute annual risk of patients with Barrett's oesophagus (BO) developing oesophageal adenocarcinoma (OAC) is ≤0.5%. Screening BO patients for malignant progression using endoscopic surveillance is widely practised. To assess the efficacy and cost-effectiveness of this, we developed a protocol for a randomized controlled trial of surveillance versus ‘at need’ endoscopy. Methods: In a multicentre trial, 3400 BO patients randomized to either 2-yearly endoscopic surveillance or ‘at need’ endoscopy will be followed up for 10 years. Urgent endoscopy will be offered to all patients who develop symptoms of dysphagia, unexplained weight loss >7lb (3.2kg), iron deficiency anaemia, recurrent vomiting, or worsening upper gastrointestinal symptoms. Participants must have endoscopically and histologically confirmed BO, with circumferential BO ≥1cm or maximal tongue/island length ≥2 cm. Candidates with existing oesophageal high-grade dysplasia or cancer, or previous upper gastrointestinal cancer will be excluded. Primary outcome will be overall survival. Secondary outcomes will be cost effectiveness (cost per life year saved and quality adjusted life years); cancer-specific survival; time to OAC diagnosis and stage at diagnosis; morbidity and mortality related to any interventions; and frequency of endoscopy. Conclusions: This randomized trial will provide data to evaluate the efficacy and cost-effectiveness of screening BO patients for OAC. [ABSTRACT FROM AUTHOR]

Published
2015
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