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2. A characterization of Hermitian varieties as codewords

Author

Aguglia, A., Bartoli, D., Storme, L., and Weiner, Zs.

Subjects
Mathematics - Combinatorics, 51E20, 94B05
Abstract

It is known that the Hermitian varieties are codewords in the code defined by the points and hyperplanes of the projective spaces $PG(r,q^2)$. In finite geometry, also quasi-Hermitian varieties are defined. These are sets of points of $PG(r,q^2)$ of the same size as a non-singular Hermitian variety of $PG(r,q^2)$, having the same intersection sizes with the hyperplanes of $PG(r,q^2)$. In the planar case, this reduces to the definition of a unital. A famous result of Blokhuis, Brouwer, and Wilbrink states that every unital in the code of the points and lines of $PG(2,q^2)$ is a Hermitian curve. We prove a similar result for the quasi-Hermitian varieties in $PG(3,q^2)$, $q=p^{h}$, as well as in $PG(r,q^2)$, $q=p$ prime, or $q=p^2$, $p$ prime, and $r\geq 4$.

Published
2017

24. How Does a Delay Between Temperate Running Exercise and Hot-Water Immersion Alter the Acute Thermoregulatory Response and Heat-Load?

Author

Storme L. Heathcote, Peter Hassmén, Shi Zhou, Lee Taylor, and Christopher J. Stevens

Subjects
heat acclimation, heat stress, hot bath, passive heating, endurance athletes, Physiology, QP1-981
Abstract

Hot-water immersion following exercise in a temperate environment can elicit heat acclimation in endurance-trained individuals. However, a delay between exercise cessation and immersion is likely a common occurrence in practice. Precisely how such a delay potentially alters hot-water immersion mediated acute physiological responses (e.g., total heat-load) remains unexplored. Such data would aid in optimizing prescription of post-exercise hot-water immersion in cool environments, relative to heat acclimation goals. Twelve male recreational runners (mean ± SD; age: 38 ± 13 years, height: 180 ± 7 cm, body mass: 81 ± 13.7 kg, body fat: 13.9 ± 3.5%) completed three separate 40-min treadmill runs (18°C), followed by either a 10 min (10M), 1 h (1H), or 8 h (8H) delay, prior to a 30-min hot-water immersion (39°C), with a randomized crossover design. Core and skin temperatures, heart rate, sweat, and perceptual responses were measured across the trials. Mean core temperature during immersion was significantly lower in 1H (37.39 ± 0.30°C) compared to 10M (37.83 ± 0.24°C; p = 0.0032) and 8H (37.74 ± 0.19°C; p = 0.0140). Mean skin temperature was significantly higher in 8H (32.70 ± 0.41°C) compared to 10M (31.93 ± 0.60°C; p = 0.0042) at the end of the hot-water immersion. Mean and maximal heart rates were also higher during immersion in 10M compared to 1H and 8H (p < 0.05), despite no significant differences in the sweat or perceptual responses. The shortest delay between exercise and immersion (10M) provoked the greatest heat-load during immersion. However, performing the hot-water immersion in the afternoon (8H), which coincided with peak circadian body temperature, provided a larger heat-load stimulus than the 1 h delay (1H).

Published
2019
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29. Passive Heating: Reviewing Practical Heat Acclimation Strategies for Endurance Athletes

Author

Storme L. Heathcote, Peter Hassmén, Shi Zhou, and Christopher J. Stevens

Subjects
passive heating, heat acclimation, hot-water immersion, thermal adaptation, hot bath, sauna, Physiology, QP1-981
Abstract

Heat acclimation protocols—both active and passive—have been employed by athletes in an effort to attenuate the detrimental effects of heat stress on physical capacities and sports performance. Active strategies have been extensively reviewed, but have various practical and economic limitations. The purpose of this review was therefore to provide an overview of the passive strategies that have received less attention, yet may be more practical or economically viable; recommendations for athletes are also provided. With a systematic search of the relevant databases ending in June 2018, 16 articles on passive heat acclimation that met the inclusion criteria were included in the review. The review highlighted that passive heat acclimation strategies can successfully induce heat adaptations, evident by reports of improved exercise performance, thermoregulatory, cardiovascular, and perceptual responses accompanying such interventions. Based on the review it is apparent that the use of sauna, hot-water immersion and environmental chambers may be used to provide heat stress under passive conditions, for the purpose of acclimation. To maximize the thermoregulatory-adaptive responses, exercise bouts should be employed prior to passive heat stress, rather than passive heating alone, with a minimal delay between exercise and the application of heat stress. Heating bouts should have a minimum duration of 30 min per session and be employed on consecutive days, when possible, with a minimum of 6–7 exposures to induce adaptation. This review identified that information regarding the magnitude of performance changes that can occur, as well as the perceptual responses to passive heating protocols is limited. Future research should investigate the use of passive heat exposures before and/or after repeated heat training sessions, to assess if a further boost to heat adaptation can be achieved with this strategy.

Published
2018
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37. Extracorporeal Membrane Oxygenation in Children with Coronavirus Disease 2019: Preliminary Report from the Collaborative European Chapter of the Extracorporeal Life Support Organization Prospective Survey

Author

Di Nardo, M, Hoskote, A, Thiruchelvam, T, Lillie, J, Horan, M, Belda Hofheinz, S, Dupic, L, Gimeno, R, De Piero, M, Lo Coco, V, Roeleveld, P, Davidson, M, Jones, T, Broman, L, Lorusso, R, Belohlavek, J, Cavallaro, G, Zanai, R, Agati, S, Amodeo, A, Lorini, F, Grazioli, L, Moscatelli, A, Amigoni, A, Brissaud, O, Tafer, N, Rambaud, J, Leger, P, Tissieres, P, Didier, C, Boet, A, Lebel, S, Berthomieu, L, Guilbert, A, Bourgoin, P, Wildschut, E, Kneyber, M, Mikael Broman, L, Miera, O, Kumpf, M, Knies, R, Schaible, T, Stiller, B, Vobruba, V, Lopez-Herce, J, Segura Matute, S, Balcells, J, Modesto I Alapont, V, Belda, S, Montanes, E, Schnur, J, Maraczi, V, Mendonca, M, Llevadias, J, Westrope, C, Desai, A, Ellis, D, Farley, M, Humphrey, A, Rautiainen, P, Abecasis, F, Vlasselaers, D, Vercaemst, L, Willems, J, Kelly, C, Joseph, S, Pollak, U, Simma, B, Schweiger, M, Gkouziouta, A, Storme, L, Di Nardo M., Hoskote A., Thiruchelvam T., Lillie J., Horan M., Belda Hofheinz S., Dupic L., Gimeno R., De Piero M. E., Lo Coco V., Roeleveld P., Davidson M., Jones T., Broman L. M., Lorusso R., Belohlavek J., Cavallaro G., Zanai R., Agati S., Amodeo A., Lorini FL., Grazioli L., Moscatelli A., Amigoni A., Brissaud O., Tafer N., Rambaud J., Leger P. -L., Tissieres P., Didier C., Boet A., Lebel S., Berthomieu L., Guilbert A. -S., Bourgoin P., Wildschut E. D., Roeleveld P. P., Kneyber M., Mikael Broman L., Miera O., Kumpf M., Knies R., Schaible T., Stiller B., Vobruba V., Lopez-Herce J., Segura Matute S., Balcells J., Modesto I Alapont V., Belda S., Montanes E., Schnur J., Maraczi V., Mendonca M., Llevadias J., Westrope C., Desai A., Ellis D., Farley M., Humphrey A., Rautiainen P., Abecasis F., Vlasselaers D., Vercaemst L., Willems J., Kelly C., Joseph S., Pollak U., Simma B., Schweiger M., Gkouziouta A., Storme L., Di Nardo, M, Hoskote, A, Thiruchelvam, T, Lillie, J, Horan, M, Belda Hofheinz, S, Dupic, L, Gimeno, R, De Piero, M, Lo Coco, V, Roeleveld, P, Davidson, M, Jones, T, Broman, L, Lorusso, R, Belohlavek, J, Cavallaro, G, Zanai, R, Agati, S, Amodeo, A, Lorini, F, Grazioli, L, Moscatelli, A, Amigoni, A, Brissaud, O, Tafer, N, Rambaud, J, Leger, P, Tissieres, P, Didier, C, Boet, A, Lebel, S, Berthomieu, L, Guilbert, A, Bourgoin, P, Wildschut, E, Kneyber, M, Mikael Broman, L, Miera, O, Kumpf, M, Knies, R, Schaible, T, Stiller, B, Vobruba, V, Lopez-Herce, J, Segura Matute, S, Balcells, J, Modesto I Alapont, V, Belda, S, Montanes, E, Schnur, J, Maraczi, V, Mendonca, M, Llevadias, J, Westrope, C, Desai, A, Ellis, D, Farley, M, Humphrey, A, Rautiainen, P, Abecasis, F, Vlasselaers, D, Vercaemst, L, Willems, J, Kelly, C, Joseph, S, Pollak, U, Simma, B, Schweiger, M, Gkouziouta, A, Storme, L, Di Nardo M., Hoskote A., Thiruchelvam T., Lillie J., Horan M., Belda Hofheinz S., Dupic L., Gimeno R., De Piero M. E., Lo Coco V., Roeleveld P., Davidson M., Jones T., Broman L. M., Lorusso R., Belohlavek J., Cavallaro G., Zanai R., Agati S., Amodeo A., Lorini FL., Grazioli L., Moscatelli A., Amigoni A., Brissaud O., Tafer N., Rambaud J., Leger P. -L., Tissieres P., Didier C., Boet A., Lebel S., Berthomieu L., Guilbert A. -S., Bourgoin P., Wildschut E. D., Roeleveld P. P., Kneyber M., Mikael Broman L., Miera O., Kumpf M., Knies R., Schaible T., Stiller B., Vobruba V., Lopez-Herce J., Segura Matute S., Balcells J., Modesto I Alapont V., Belda S., Montanes E., Schnur J., Maraczi V., Mendonca M., Llevadias J., Westrope C., Desai A., Ellis D., Farley M., Humphrey A., Rautiainen P., Abecasis F., Vlasselaers D., Vercaemst L., Willems J., Kelly C., Joseph S., Pollak U., Simma B., Schweiger M., Gkouziouta A., and Storme L.

Published
2021

50. NOS1 mutations cause hypogonadotropic hypogonadism with sensory and cognitive deficits that can be reversed in infantile mice

Author

Chachlaki, K. Messina, A. Delli, V. Leysen, V. Maurnyi, C. Huber, C. Ternier, G. Skrapits, K. Papadakis, G. Shruti, S. Kapanidou, M. Cheng, X. Acierno, J. Rademaker, J. Rasika, S. Quinton, R. Niedziela, M. L'Allemand, D. Pignatelli, D. Dirlewander, M. Lang-Muritano, M. Kempf, P. Catteau-Jonard, S. Niederländer, N.J. Ciofi, P. Tena-Sempere, M. Garthwaite, J. Storme, L. Avan, P. Hrabovszky, E. Carleton, A. Santoni, F. Giacobini, P. Pitteloud, N. Prevot, V. and Chachlaki, K. Messina, A. Delli, V. Leysen, V. Maurnyi, C. Huber, C. Ternier, G. Skrapits, K. Papadakis, G. Shruti, S. Kapanidou, M. Cheng, X. Acierno, J. Rademaker, J. Rasika, S. Quinton, R. Niedziela, M. L'Allemand, D. Pignatelli, D. Dirlewander, M. Lang-Muritano, M. Kempf, P. Catteau-Jonard, S. Niederländer, N.J. Ciofi, P. Tena-Sempere, M. Garthwaite, J. Storme, L. Avan, P. Hrabovszky, E. Carleton, A. Santoni, F. Giacobini, P. Pitteloud, N. Prevot, V.

Abstract

The nitric oxide (NO) signaling pathway in hypothalamic neurons plays a key role in the regulation of the secretion of gonadotropin-releasing hormone (GnRH), which is crucial for reproduction. We hypothesized that a disruption of neuronal NO synthase (NOS1) activity underlies some forms of hypogonadotropic hypogonadism. Whole-exome sequencing was performed on a cohort of 341 probands with congenital hypogonadotropic hypogonadism to identify ultrarare variants in NOS1. The activity of the identified NOS1 mutant proteins was assessed by their ability to promote nitrite and cGMP production in vitro. In addition, physiological and pharmacological characterization was carried out in a Nos1-deficient mouse model. We identified five heterozygous NOS1 loss-of-function mutations in six probands with congenital hypogonadotropic hypogonadism (2%), who displayed additional phenotypes including anosmia, hearing loss, and intellectual disability. NOS1 was found to be transiently expressed by GnRH neurons in the nose of both humans and mice, and Nos1 deficiency in mice resulted in dose-dependent defects in sexual maturation as well as in olfaction, hearing, and cognition. The pharmacological inhibition of NO production in postnatal mice revealed a critical time window during which Nos1 activity shaped minipuberty and sexual maturation. Inhaled NO treatment at minipuberty rescued both reproductive and behavioral phenotypes in Nos1-deficient mice. In summary, lack of NOS1 activity led to GnRH deficiency associated with sensory and intellectual comorbidities in humans and mice. NO treatment during minipuberty reversed deficits in sexual maturation, olfaction, and cognition in Nos1 mutant mice, suggesting a potential therapy for humans with NO deficiency. © 2022 The Authors.

Published
2022

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