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1. Weaningversagen

Author

Storre, Jan Hendrik, Brülls, Christian, Bickenbach, Johannes, editor, Marx, Gernot, editor, Dreher, Michael, editor, and Schönhofer, Bernd, editor

Published
2018
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4. Assessment of Sleep in Patients Receiving Invasive Mechanical Ventilation in a Specialized Weaning Unit

Author

Huttmann, Sophie Emilia, Wilms, Katharina, Hamm, Christine, Magnet, Friederike Sophie, Windisch, Wolfram, and Storre, Jan Hendrik

Subjects
Health
Abstract

Author(s): Sophie Emilia Huttmann [sup.1] , Katharina Wilms [sup.1] , Christine Hamm [sup.1] , Friederike Sophie Magnet [sup.1] , Wolfram Windisch [sup.1 ] , Jan Hendrik Storre [sup.1] [sup.2 ] [...]

Published
2017
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10. Patient-Ventilator Synchronization During Non-invasive Ventilation: A Pilot Study of an Automated Analysis System

Author

Letellier, Christophe, primary, Lujan, Manel, additional, Arnal, Jean-Michel, additional, Carlucci, Annalisa, additional, Chatwin, Michelle, additional, Ergan, Begum, additional, Kampelmacher, Mike, additional, Storre, Jan Hendrik, additional, Hart, Nicholas, additional, Gonzalez-Bermejo, Jesus, additional, and Nava, Stefano, additional

Published
2021
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18. Home noninvasive ventilatory support for patients with chronic obstructive pulmonary disease: patient selection and perspectives

Author

Storre,Jan Hendrik, Callegari,Jens, Magnet,Friederike Sophie, Schwarz,Sarah Bettina, Duiverman,Marieke Leontine, Wijkstra,Peter Jan, and Windisch,Wolfram

Subjects
International Journal of Chronic Obstructive Pulmonary Disease
Abstract

Jan Hendrik Storre,1,2 Jens Callegari,3 Friederike Sophie Magnet,3 Sarah Bettina Schwarz,3 Marieke Leontine Duiverman,4,5 Peter Jan Wijkstra,4,5 Wolfram Windisch3 1Department of Intensive Care, Sleep Medicine and Mechanical Ventilation, Asklepios Fachkliniken Munich-Gauting, Gauting, Germany; 2Department of Pneumology, University Medical Hospital, Freiburg, Germany; 3Department of Pneumology, Cologne Merheim Hospital, Kliniken der Stadt Köln gGmbH Witten/Herdecke University, Faculty of Health/School of Medicine, Cologne, Germany; 4Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; 5Groningen Research Institute of Asthma and COPD (GRIAC), University of Groningen, Groningen, the Netherlands Abstract: Long-term or home mechanical noninvasive ventilation (Home-NIV) has become a well-established form of therapy over the last few decades for chronic hypercapnic COPD patients in European countries. However, meta-analyses and clinical guidelines do not recommend Home-NIV for COPD patients on a routine basis. In particular, there is ongoing debate about Home-NIV in chronic hypercapnic COPD regarding the overall effects, the most favorable treatment strategy, the selection of eligible patients, and the time point at which it is prescribed. The current review focuses on specific aspects of patient selection and discusses the various scientific as well as clinical-guided perspectives on Home-NIV in patients suffering from chronic hypercapnic COPD. In addition, special attention will be given to the topic of ventilator settings and interfaces. Keywords: exacerbation, pulmonary emphysema, hypercapnia, mechanical ventilation, respiratory insufficiency

Published
2018

19. European Respiratory Society guidelines on long-term home non-invasive ventilation for management of COPD

Author

Ergan, Begum, primary, Oczkowski, Simon, additional, Rochwerg, Bram, additional, Carlucci, Annalisa, additional, Chatwin, Michelle, additional, Clini, Enrico, additional, Elliott, Mark, additional, Gonzalez-Bermejo, Jesus, additional, Hart, Nicholas, additional, Lujan, Manel, additional, Nasilowski, Jacek, additional, Nava, Stefano, additional, Pepin, Jean Louis, additional, Pisani, Lara, additional, Storre, Jan Hendrik, additional, Wijkstra, Peter, additional, Tonia, Thomy, additional, Boyd, Jeanette, additional, Scala, Raffaele, additional, and Windisch, Wolfram, additional

Published
2019
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20. Capillary PO2 does not adequately reflect arterial PO2 in hypoxemic COPD patients

Author

Magnet,Friederike Sophie, Majorski,Daniel, Sebastian, Callegari,Jens, Schwarz,Sarah Bettina, Schmoor,Claudia, Windisch,Wolfram, and Storre,Jan Hendrik

Subjects
respiratory system, International Journal of Chronic Obstructive Pulmonary Disease, circulatory and respiratory physiology, respiratory tract diseases
Abstract

Friederike Sophie Magnet,1 Daniel Sebastian Majorski,1 Jens Callegari,1 Sarah Bettina Schwarz,1 Claudia Schmoor,2 Wolfram Windisch,1 Jan Hendrik Storre3,4 1Department of Pneumology, Cologne Merheim Hospital, Kliniken der Stadt Köln gGmbH Witten/Herdecke University, Faculty of Health/School of Medicine, Cologne, Germany; 2Clinical Trials Unit, Medical Center– University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; 3Department of Intensive Care, Sleep Medicine and Mechanical Ventilation, Asklepios Fachkliniken Munich-Gauting, Gauting, Germany; 4Department of Pneumology, University Medical Hospital, Freiburg, Germany Purpose: To compare arterial (PaO2) with capillary (PcO2) partial pressure of oxygen in hypoxemic COPD patients because capillary blood gas analysis (CBG) is increasingly being used as an alternative to arterial blood gas analysis (ABG) in a non-intensive care unit setting, although the agreement between PcO2 and PaO2 has not been evaluated in hypoxemic COPD patients.Patients and methods: Bland–Altman comparison of PaO2 and PcO2 served as the primary outcome parameter if PcO2 values were ≤60 mmHg and the secondary outcome parameter if PcO2 values were ≤55 mmHg. Pain associated with the measurements was assessed using a 100-mm visual analog scale.Results: One hundred and two PaO2/PcO2 measurement pairs were obtained. For PcO2 values ≤60 mmHg, the mean difference between PaO2 and PcO2 was 5.99±6.05 mmHg (limits of agreement: -5.88 to 17.85 mmHg). For PcO2 values ≤55 mmHg (n=73), the mean difference was 5.33±5.52 mmHg (limits of agreement: -5.48 to 16.15 mmHg). If PaO2 ≤55 (≤60) mmHg was set as the cut-off value, in 20.6% (30.4%) of all patients, long-term oxygen therapy have been unnecessarily prescribed if only PcO2 would have been assessed. ABG was rated as more painful compared with CBG.Conclusions: PcO2 does not adequately reflect PaO2 in hypoxemic COPD patients, which can lead to a relevant number of unnecessary long-term oxygen therapy prescriptions. Keywords: blood gas analysis, COPD, respiratory insufficiency, hypoxemia

Published
2017

23. Interfaces and ventilator settings for long-term noninvasive ventilation in COPD patients

Author

Callegari,Jens, Magnet,Friederike, Taubner,Steven, Berger,Melanie, Schwarz,Sarah, Windisch,Wolfram, Storre,Jan Hendrik, Callegari,Jens, Magnet,Friederike, Taubner,Steven, Berger,Melanie, Schwarz,Sarah, Windisch,Wolfram, and Storre,Jan Hendrik

Abstract

Jens Callegari,1 Friederike Sophie Magnet,1 Steven Taubner,1 Melanie Berger,2 Sarah Bettina Schwarz,1 Wolfram Windisch,1 Jan Hendrik Storre3,4 1Department of Pneumology, Cologne-Merheim Hospital, Kliniken der Stadt Koeln, Witten/Herdecke University Hospital, 2Department of Pneumology, Malteser Hospital St Hildegardis, Cologne, 3Department of Pneumology, University Medical Hospital, Freiburg, 4Department of Intensive Care, Sleep Medicine and Mechanical Ventilation, Asklepios Fachkliniken Munich-Gauting, Gauting, Germany Introduction: The establishment of high-intensity (HI) noninvasive ventilation (NIV) that targets elevated PaCO2 has led to an increase in the use of long-term NIV to treat patients with chronic hypercapnic COPD. However, the role of the ventilation interface, especially in more aggressive ventilation strategies, has not been systematically assessed.Methods: Ventilator settings and NIV compliance were assessed in this prospective cross-sectional monocentric cohort study of COPD patients with pre-existing NIV. Daytime ­arterialized blood gas analyses and lung function testing were also performed. The primary end point was the distribution among study patients of interfaces (full-face masks [FFMs] vs nasal masks [NMs]) in a real-life setting.Results: The majority of the 123 patients studied used an FFM (77%), while 23% used an NM. Ventilation settings were as follows: mean ± standard deviation (SD) inspiratory positive airway pressure (IPAP) was 23.2±4.6 mbar and mean ± SD breathing rate was 16.7±2.4/minute. Pressure support ventilation (PSV) mode was used in 52.8% of patients, while assisted pressure-controlled ventilation (aPCV) was used in 47.2% of patients. Higher IPAP levels were associated with an increased use of FFMs (IPAP <21 mbar: 73% vs IPAP >25 mbar: 84%). Mean compliance was 6.5 hours/day, with no differences between FFM (6.4&n

Published
2017

31. Schlafqualität im prolongierten Weaning

Author

Huttmann, Sophie, Wilms, Katharina, Hamm, Christine, Windisch, Wolfram, and Storre, Jan Hendrik

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Ein erholsamer Schlaf ist wichtig für die allgemeine Regeneration des Organismus und das Wohlbefinden eines Menschen. Studien haben gezeigt, dass der Schlaf bei invasiv beatmeten Patienten auf der Intensivstation schwer gestört sein kann. Über Schlafqualität auf der [for full text, please go to the a.m. URL], 23. Jahreskongress der Deutschen Interdisziplinären Gesellschaft für Außerklinische Beatmung (DIGAB) e.V.

Published
2015
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32. Invasive außerklinische Beatmungstherapie: Lebensbedingungen und gesundheitsbezogene Lebensqualität

Author

Huttmann, Sophie, Windisch, Wolfram, and Storre, Jan Hendrik

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Durch Fortschritte der Medizin werden stetig steigende Patientenzahlen von Langzeitbeatmeten generiert, die letztlich nicht von der Beatmung zu entwöhnen sind und diese im außerklinischen Umfeld fortführen. Diese Patienten haben eine stark eingeschränkte Prognose. Bezüglich[for full text, please go to the a.m. URL], 23. Jahreskongress der Deutschen Interdisziplinären Gesellschaft für Außerklinische Beatmung (DIGAB) e.V.

Published
2015

35. Validity and Usability of Physical Activity Monitoring in Patients with Chronic Obstructive Pulmonary Disease (COPD)

Author

Boeselt, Tobias, primary, Spielmanns, Marc, additional, Nell, Christoph, additional, Storre, Jan Hendrik, additional, Windisch, Wolfram, additional, Magerhans, Lena, additional, Beutel, Bjoern, additional, Kenn, Klaus, additional, Greulich, Timm, additional, Alter, Peter, additional, Vogelmeier, Claus, additional, and Koczulla, Andreas Rembert, additional

Published
2016
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37. Spot Check Analysis of Gas Exchange: Invasive versus Noninvasive Methods

Author

Ekkernkamp, Emelie, Welte, Lena, Schmoor, Claudia, Huttmann, Sophie Emilia, Dreher, Michael, Windisch, Wolfram, Storre, Jan Hendrik, Ekkernkamp, Emelie, Welte, Lena, Schmoor, Claudia, Huttmann, Sophie Emilia, Dreher, Michael, Windisch, Wolfram, and Storre, Jan Hendrik

Abstract

Background: Correct measurement of PO2 and PCO2 is essential to establish appropriate therapy such as long-term oxygen therapy (LTOT) in patients suffering from respiratory failure. Objectives: We aimed to compare common invasive and noninvasive methods for assessing blood gas components for spot check analysis. Methods: Arterial (PaO2, PaCO2) and capillary blood gas (PCBGO2, PCBGCO2) measurements were taken consecutively in a randomized order and were compared with noninvasive measurements obtained from the transcutaneous monitoring of PO2 and PCO2 (PtcO2, PtcC2, sensor-temperature 44 degrees C). Capillary samples were taken from both arterialized earlobes, where samples of right earlobes were defined as a reference value. Pain assessment of all measurements was evaluated by each subject using the 100-mm visual analogue scale. Results: 83 patients and 17 healthy subjects were included. The mean difference between PaO2 and PtcO2 was 11.9 +/- 15.0 mm Hg, with lower limits of agreement (LLA) of -17.4 mm Hg (95% confidence interval (CI) -22.5 to -12.3 mm Hg), and upper limits of agreement (ULA) of 41.1 mm Hg (95% CI 36.0-46.2 mm Hg). The comparison of PaO2 with PCBGO2 showed a mean difference of 5.6 +/- 7.2 mm Hg (LLA -11.0; ULA 19.6 mm Hg). The mean difference between PaCO2 and PtcCO2 was 1.1 +/- 4.9 mm Hg (LLA -8.6; ULA 10.8 mm Hg) and that between PaCO2 and PCBGCO2 was 0.7 +/- 2.0 mm Hg (LLA -3.3; ULA 4.8 mm Hg). The analysis of capillary blood gases (36.2 +/- 22.3 mm) was rated as more painful than the analysis of arterial blood gases (26.1 +/- 20.6 mm), while transcutaneous measurement was rated as the least painful method (1.9 +/- 7.4 mm; all p < 0.0001). Conclusions: The comparison of different methods for blood gas measurements showed substantial differences between capillary and arterial PO2 and between transcutaneous and arterial PO2. Therefore, arterial PO2 analysis is the essential method evaluating indication for LTOT. Nevertheless, comparative analysis fu

Published
2015

38. Biometric approximation of diaphragmatic contractility during sustained hyperpnea

Author

Kabitz, Hans-Joachim, Walker, David Johannes, Schwoerer, Anja, Schlager, Daniel, Walterspacher, Stephan, Storre, Jan Hendrik, Roecker, Kai, Windisch, Wolfram, Vergès, Samuel, Spengler, Christina M, and University of Zurich

Subjects
2740 Pulmonary and Respiratory Medicine, 10076 Center for Integrative Human Physiology, 570 Life sciences, biology, 2800 General Neuroscience, 610 Medicine & health, 1314 Physiology
Published
2011

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