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26 results on '"Strüssmann, Tim"'

1. Hematopoietic stem cell transplantation for DLBCL: a report from the European Society for Blood and Marrow Transplantation on more than 40,000 patients over 32 years

Author

Berning, Philipp, Fekom, Mathilde, Ngoya, Maud, Goldstone, Anthony H., Dreger, Peter, Montoto, Silvia, Finel, Hervé, Shumilov, Evgenii, Chevallier, Patrice, Blaise, Didier, Strüssmann, Tim, Carpenter, Ben, Forcade, Edouard, Castilla-Llorente, Cristina, Trneny, Marek, Ghesquieres, Hervé, Capria, Saveria, Thieblemont, Catherine, Blau, Igor Wolfgang, Meijer, Ellen, Broers, Annoek E. C., Huynh, Anne, Caillot, Denis, Rösler, Wolf, Nguyen Quoc, Stephanie, Bittenbring, Jörg, Nagler, Arnon, Galimard, Jacques-Emmanuel, Glass, Bertram, Sureda, Anna, and Schmitz, Norbert

Published
2024
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3. Timing of high-dose methotrexate CNS prophylaxis in DLBCL: a multicenter international analysis of 1384 patients

Author

Wilson, Matthew R., Eyre, Toby A., Kirkwood, Amy A., Wong Doo, Nicole, Soussain, Carole, Choquet, Sylvain, Martinez-Calle, Nicolás, Preston, Gavin, Ahearne, Matthew, Schorb, Elisabeth, Moles-Moreau, Marie-Pierre, Ku, Matthew, Rusconi, Chiara, Khwaja, Jahanzaib, Narkhede, Mayur, Lewis, Katharine L., Calimeri, Teresa, Durot, Eric, Renaud, Loïc, Øvlisen, Andreas Kiesbye, McIlroy, Graham, Ebsworth, Timothy J., Elliot, Johnathan, Santarsieri, Anna, Ricard, Laure, Shah, Nimish, Liu, Qin, Zayac, Adam S., Vassallo, Francesco, Lebras, Laure, Roulin, Louise, Lombion, Naelle, Manos, Kate, Fernandez, Ruben, Hamad, Nada, Lopez-Garcia, Alberto, O'Mahony, Deirdre, Gounder, Praveen, Forgeard, Nathalie, Lees, Charlotte, Agbetiafa, Kossi, Strüßmann, Tim, Htut, Thura Win, Clavert, Aline, Scott, Hamish, Guidetti, Anna, Barlow, Brett R., Tchernonog, Emmanuelle, Smith, Jeffery, Miall, Fiona, Fox, Christopher P., Cheah, Chan Y., El Galaly, Tarec Christoffer, Ferreri, Andrés J.M., Cwynarski, Kate, and McKay, Pamela

Published
2022
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5. Reduced Intensity Conditioning Prior Autologous Stem Cell Transplantation in Elderly DLBCL Patients.

Author

Strüßmann, Tim, Hermes, Philipp, Ihorst, Gabriele, Finke, Jürgen, Duque‐Afonso, Jesús, Engelhardt, Monika, Duyster, Justus, and Marks, Reinhard

Subjects
*STEM cell transplantation, *OLDER patients, *OVERALL survival, *MULTIVARIATE analysis, *UNIVARIATE analysis
Abstract

ABSTRACT High‐dose chemotherapy (HDCT) followed by autologous stem cell transplantation (ASCT) is widely used in patients with diffuse large B‐cell lymphoma. HDCT/ASCT is associated with increased morbidity in elderly/unfit patients. We retrospectively evaluated the use of reduced intensity conditioning in DLBCL patients. Our study included 146 patients aged 60 years and older treated at our institution between 2005 and 2019; 86 patients received standard intensity conditioning (SI group) with BEAM or TEAM (BCNU or thiotepa, etoposide, cytarabine, melphalan). Sixty patients received reduced intensity high‐dose conditioning (RI group) with BM (BCNU, melphalan, 43.3%), TM (thiotepa, melphalan, 16.7%), BCNU or busulfan thiotepa (38.4%), or bendamustine melphalan (1.7%). Median follow‐up was 62.4 months. We observed comparable toxicities in the SI and RI groups. The cumulative incidence of relapse at 3 years was higher in the RI group (30.8% vs. 23.4%, p = 0.034). There was no difference in nonrelapse mortality (NRM). In univariate analyses, SI vs. RI conditioning resulted in superior progression‐free survival (PFS) (HR 1.80 CI 1.11–2.92, p = 0.017) but not in superior overall survival (OS) (HR 1.48 CI 0.86–2.56, p = 0.152). On multivariate analysis, we observed no difference in PFS (HR 0.74 CI 0.40–1.38, p = 0.345) and a trend toward better OS with RI conditioning (HR 0.45 CI 0.22–0.94, p = 0.032). Age 60–69 versus ≥ 70 years and remission prior to ASCT were the only factors predicting better PFS. Factors associated with better OS were RI conditioning, age 60–69 versus ≥ 70 years, ECOG 0 versus ≥ 1 performance status, bulky disease, and prior lines 1 versus ≥ 2. In conclusion, RI conditioning prior to ASCT may be feasible in elderly patients and led to a comparable outcome when corrected for several significant confounders. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Identification of clinical factors impacting outcome in patients undergoing autologous hematopoietic cell transplantation after BEAM and TEAM conditioning.

Author

Gherman, Radu‐Florian, Ewald, Sophie, Ihorst, Gabriele, Strüßmann, Tim, Zeiser, Robert, Wäsch, Ralph, Bertz, Hartmut, Stolz, Daiana, Duyster, Justus, Finke, Jürgen, Marks, Reinhard, Engelhardt, Monika, and Duque‐Afonso, Jesús

Subjects
STEM cell transplantation, HEMATOPOIETIC stem cell transplantation, TREATMENT effectiveness, KARNOFSKY Performance Status, SEVERE combined immunodeficiency
Abstract

Organ dysfunction, including pulmonary function impairment, plays a key role in the choice of conditioning chemotherapy before autologous hematopoietic stem cell transplantation (auto‐HSCT). Replacement of BCNU/carmustine as part of BEAM (BCNU/carmustine, etoposide, cytarabine, and melphalan) conditioning protocol by thiotepa (TEAM) reduces pulmonary toxicity while maintaining efficacy. We retrospectively analyzed the association of clinical characteristics, comorbidities, and organ function with outcomes after conditioning with BEAM or TEAM. Three hundred ninety‐six patients undergoing auto‐HSCT (n = 333 with BEAM; n = 63 with TEAM) at our institution between 2008 and 2021 were included in this study. In the multivariate analysis, CO‐diffusion capacity corrected for hemoglobin (DLCOcSB) ≤ 60% of predicted, progressive disease (PD) before auto‐HSCT, Karnofsky performance score (KPS) ≤ 80%, HCT‐CI score ≥ 4, and cardiac disease before auto‐HSCT were associated with decreased overall survival (OS) in patients treated with BEAM. In contrast, only PD before auto‐HSCT was identified in patients treated with TEAM. Patients conditioned with BEAM and DLCOcSB ≤ 60% had higher non‐relapse mortality, including pulmonary cause of death. In summary, we have identified clinical and pulmonary risk factors associated with worse outcomes in patients conditioned with BEAM compared to TEAM. Our data suggest TEAM conditioning as a valid alternative for patients with comorbidities, including pulmonary dysfunction and/or poorer performance scores, before auto‐HSCT. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Single-Center Experience of Decitabine/Venetoclax in Newly Diagnosed Older AML Patients with Non-Favorable Genetics: Bridging to Allo-HCT or Treatment Continuation

Author

Alber, David, primary, Rummelt, Christoph, additional, Strüßmann, Tim, additional, Rettig, Andrés, additional, Shlyakhto, Valeria, additional, La Rosée, Paul, additional, Henkes, Martin, additional, Bubnova, Elizaveta, additional, Ma, Tobias, additional, Thomas, Johanna, additional, Ihorst, Gabriele, additional, Wehr, Claudia, additional, Marks, Reinhard, additional, Becker, Heiko, additional, Duyster, Justus, additional, Wäsch, Ralph, additional, Finke, Jürgen, additional, and Lübbert, Michael, additional

Published
2023
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11. Identification of clinical factors impacting outcome in patients undergoing autologous hematopoietic cell transplantation after BEAM and TEAM conditioning

Author

Gherman, Radu‐Florian, primary, Ewald, Sophie, additional, Ihorst, Gabriele, additional, Strüßmann, Tim, additional, Zeiser, Robert, additional, Wäsch, Ralph, additional, Bertz, Hartmut, additional, Stolz, Daiana, additional, Duyster, Justus, additional, Finke, Jürgen, additional, Marks, Reinhard, additional, Engelhardt, Monika, additional, and Duque‐Afonso, Jesús, additional

Published
2023
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13. Dosage of high‐dose methotrexate as CNS prophylaxis in DLBCL: A detailed analysis of toxicity and impact on CNS relapse.

Author

Wilson, Matthew R., Kirkwood, Amy A., Wong Doo, Nicole, Soussain, Carole, Choquet, Sylvain, Lees, Charlotte, Fox, Christopher, Preston, Gavin, Ahearne, Matthew, Strüßmann, Tim, Clavert, Aline, Rusconi, Chiara, Ku, Matthew, Khwaja, Jahanzaib, Narkhede, Mayur, Lewis, Katharine, Durot, Eric, Smith, Jeffery, Renaud, Loic, and Ferreri, Andrés J. M.

Published
2024
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17. Favourable outcomes of double‐hit/double‐expressor lymphoma and high‐grade B‐cell lymphoma, not otherwise specified after early dose‐intensive treatment and up‐front autologous stem cell transplantation: a single‐centre retrospective experience

Author

Strüßmann, Tim, primary, Glatzki, Franziska, additional, Engelhardt, Monika, additional, Mertelsmann, Roland, additional, Duyster, Justus, additional, Finke, Jürgen, additional, and Marks, Reinhard, additional

Published
2022
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18. Early Integration of High Dose Methotrexate to Frontline DLBCL Therapy Does Not Impact CNS Relapse Compared to End of Treatment Delivery: A Multicentre International Analysis of 1384 Patients

Author

Wilson, Matthew R, primary, Eyre, Toby A., additional, Kirkwood, Amy A, additional, Wong Doo, Nicole, additional, Soussain, Carole, additional, Choquet, Sylvain, additional, Martinex-Calle, Nicolas, additional, Preston, Gavin, additional, Ahearne, Matthew J, additional, Schorb, Elisabeth, additional, Moles-Moreau, Marie-Pierre, additional, Ku, Matthew, additional, Rusconi, Chiara, additional, Khwaja, Jahanzaib, additional, Narkhede, Mayur, additional, Lewis, Katharine L, additional, Calimeri, Teresa, additional, Durot, Eric, additional, Renaud, Loic, additional, Øvlisen, Andreas Kiesbye, additional, McIlroy, Graham, additional, Ebsworth, Tim, additional, Elliot, Johnathon, additional, Santarsiere, Anna, additional, Ricard, Laure, additional, Shah, Nimish, additional, Liu, Qin, additional, Zayac, Adam, additional, Vassallo, Francesco, additional, Lebras, Laure, additional, Roulin, Louise, additional, Lombion, Naelle, additional, Manos, Kate, additional, Fernandez, Ruben, additional, Hamad, Nada, additional, Lopez-Garcia, Alberto, additional, O'Mahony, Deirdre, additional, Gounder, Praveen, additional, Forgeard, Nathalie, additional, Lees, Charlotte, additional, Agbetiafa, Kossi, additional, Strüßmann, Tim, additional, Win Htut, Thura, additional, Clavert, Aline, additional, Scott, Hamish W, additional, Guidetti, Anna, additional, Barlow, Brett R, additional, Smith, Jeffrey, additional, El-Galaly, Tarec Christoffer, additional, Cheah, Chan Yoon, additional, Ferreri, Andres JM, additional, Miall, Fiona, additional, Fox, Christopher P, additional, Cwynarski, Kate, additional, and McKay, Pamela, additional

Published
2021
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20. Early Prediction of Treatment Response By Circulating Tumor DNA Profiling in Patients with Diffuse Large B-Cell Lymphoma Receiving CAR T-Cell Therapy

Author

Foerster, Anna Katharina, Kronenthaler, Corinna, Ranganathan, Lavanya, Bandara, Samuel, Woestmann, Corinna, Yaung, Stephanie, Bleul, Sabine, Klingler, Christian, Mitschke, Jan, Wehrle, Julius, Wäsch, Ralph, Duyster, Justus, Struessmann, Tim, Finke, Jürgen, Su, Bowdoin, Marks, Reinhard, and Scherer, Florian

Published
2023
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21. Colon and liver tissue damage detection using methylated SESN3 and PTK2B genes in circulating cell-free DNA in patients with acute graft-versus-host disease

Author

Waterhouse, Miguel, primary, Pennisi, Sandra, additional, Pfeifer, Dietmar, additional, Deuter, Max, additional, von Bubnoff, Nikolas, additional, Scherer, Florian, additional, Strüssmann, Tim, additional, Wehr, Claudia, additional, Duyster, Justus, additional, Bertz, Hartmut, additional, Finke, Jürgen, additional, and Duque-Afonso, Jesus, additional

Published
2020
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