187 results on '"Straily A"'
Search Results
2. Outbreak of Human Trichinellosis--Arizona, Minnesota, and South Dakota, 2022
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Cash-Goldwasser, Shama, Ortbahn, Dustin, Narayan, Muthu, Fitzgerald, Conor, Maldonado, Keila, Currie, James, Straily, Anne, Sapp, Sarah, Bishop, Henry S., Watson, Billy, Neja, Margaret, Qvarnstrom, Yvonne, Berman, David M., Park, Sarah Y., Smith, Kirk, and Holzbauer, Stacy more...
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Trichinosis ,Zoonoses ,Vegetables ,Disease transmission ,Hospital patients ,Food contamination ,Health - Abstract
Investigation and Results Index Patient Notification In July 2022, the Minnesota Department of Health was notified of a man aged 29 years who was hospitalized with fever, severe myalgias, periorbital [...] more...
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- 2024
Catalog
3. Blood Trematodes
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Montgomery, Susan P., primary and Straily, Anne, additional
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- 2023
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4. Contributors
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Abzug, Mark J., primary, Adderson, Elisabeth E., additional, Agarwal, Aastha, additional, Agwu, Allison L., additional, Albenberg, Lindsey, additional, Albert, Jonathan, additional, Alby, Kevin, additional, Aldrovandi, Grace M., additional, Allen, Upton D., additional, Alvarez-Hernndez, Gerardo, additional, Ampofo, Krow, additional, Anderson, Evan J., additional, Appiah, Grace D., additional, Ardura, Monica I., additional, Arnon, Stephen S., additional, Aronson, Naomi E., additional, Arvin, Ann M., additional, Ashkenazi, Shai, additional, Ashkenazi-Hoffnung, Liat, additional, Asturias, Edwin J., additional, Aukstuolis, Kestutis, additional, Badalyan, Vahe, additional, Baker, Carol J., additional, Balakrishnan, Karthik, additional, Barnett, Elizabeth D., additional, Bechtel, Kirsten, additional, Benitz, William E., additional, Berkovich, Rachel, additional, Berman, David M., additional, Bialek, Stephanie R., additional, Bijker, Else M., additional, Bizzarro, Matthew J., additional, Bloch, Karen C., additional, Bocchini, Joseph A., additional, Boyce, Thomas G., additional, Bradley, John S., additional, Bratcher, Denise F., additional, Braverman, Paula K., additional, Brook, Itzhak, additional, Brown, Kevin Edward, additional, Bryant, Kristina P., additional, Camacho-Gonzalez, Andres F., additional, Caete-Gibas, Connie F., additional, Cantey, Joseph B., additional, Cantey, Paul, additional, Cardemil, Cristina V., additional, Caserta, Mary T., additional, Castagnini, Luis A., additional, Cataldi, Jessica R., additional, Chadwick, Ellen Gould, additional, Chancey, Rebecca J., additional, Cherry, Cara C., additional, Chiang, Silvia S., additional, Choi, Mary, additional, Christenson, John C., additional, Coffin, Susan E., additional, Cohn, Amanda, additional, Contopoulos-Ioannidis, Despina G., additional, Conway, James H., additional, Cortese, Margaret M., additional, Creech, C. Buddy, additional, Crews, Jonathan D., additional, Curtis, Donna, additional, Curtis, Nigel, additional, Danziger-Isakov, Lara A., additional, Darville, Toni, additional, Dasch, Gregory A., additional, Daskalaki, Irini, additional, Davies, H. Dele, additional, Dawood, Fatimah S., additional, Day, J. Christopher, additional, Teresa de la Morena, M., additional, DeMuri, Gregory P., additional, Despommier, Dickson D., additional, Dodson, Daniel S., additional, Dolgner, Stephen J., additional, Dunn, Clinton, additional, Dyal, Jonathan, additional, Edwards, Kathryn M., additional, Edwards, Morven S., additional, Eichenfield, Dawn Z., additional, Eichenfield, Lawrence F., additional, Elston, Dirk M., additional, Emerson, Beth, additional, Enane, Leslie A., additional, Ephros, Moshe, additional, Erdem, Guliz, additional, Eremeeva, Marina E., additional, Esposito, Douglas H., additional, Farley, Monica M., additional, Feingold, Anat R., additional, Feja, Kristina N., additional, Finn, Adam, additional, Fischer, Marc, additional, Fisher, Brian T., additional, Fisher, Randall G., additional, Flynn, Patricia Michele, additional, Foster, Monique A., additional, Fox, LeAnne M., additional, Frank, Michael M., additional, Fredrick, Douglas R., additional, Frenck, Robert W., additional, Gaensbauer, James, additional, Gans, Hayley A., additional, Gauthier, Gregory M., additional, Gavigan, Patrick, additional, Gerber, Jeffrey S., additional, Gernez, Yael, additional, Gigliotti, Francis, additional, Gilger, Mark A., additional, Glaser, Carol A., additional, Gould, Jane M., additional, Graziano, James, additional, Green, Amanda M., additional, Green, Michael, additional, Griffin, Daniel, additional, Griffin, Patricia M., additional, Griffith, David C., additional, Gupta, Piyush, additional, Gutelius, Bruce J., additional, Gutman, Julie R., additional, Hall, Aron J., additional, Hamdy, Rana F., additional, Han, Jin-Young, additional, Handy, Lori K., additional, Hanisch, Benjamin, additional, Harper, Marvin B., additional, Harris, Aaron M., additional, Harrison, Christopher J., additional, Haslam, David B., additional, Haston, Julia C., additional, Hawkes, Sarah.J., additional, Heald-Sargent, Taylor, additional, Hendley, J. Owen, additional, Hersh, Adam L., additional, Hilinski, Joseph A., additional, Hills, Susan L., additional, Hong, David K., additional, Hotez, Peter J., additional, Hsu, Katherine K., additional, Huang, Felicia Scaggs, additional, Hunstad, David A., additional, Hunt, W. Garrett, additional, Hwang, Loris Y., additional, Ilboudo, Christelle M., additional, Jaggi, Preeti, additional, Jean, Sophonie, additional, Jhaveri, Ravi, additional, Jirk-Pomajbkov, Kateina, additional, Kadry, Nadia A., additional, Kamb, Mary L., additional, Kapadia, Ronak K., additional, Katz, Ben Z., additional, Katz, Sophie E., additional, Kaur, Ishminder, additional, Kersh, Gilbert J., additional, Khan, Muhammad Ali, additional, Khurana, Ananta, additional, Kimberlin, David W., additional, Klein, Bruce, additional, Kobayashi, Miwako, additional, Kociolek, Larry K., additional, Koh, Andrew Y., additional, Kotloff, Karen L., additional, Kroger, Andrew T., additional, Kronman, Matthew P., additional, Lalor, Leah, additional, Lauren, Christine T., additional, Leber, Amy, additional, Leshem, Eyal, additional, Lewis, David B., additional, Livingston, Robyn A., additional, Llata, Eloisa, additional, Lloyd, Kevin, additional, Loh, Katrina, additional, Long, Sarah S., additional, Lopman, Benjamin A., additional, Lucero, Yalda C., additional, Lugo, Debra J., additional, Lujn-Zilbermann, Jorge, additional, Maldonado, Yvonne A., additional, Manaloor, John J., additional, Manthiram, Kalpana, additional, Martin, Stacey W., additional, Mathew, Roshni, additional, Mazzulli, Tony, additional, McFarland, Elizabeth J., additional, McGann, Kathleen A., additional, McNamara, Lucy A., additional, Meislich, Debrah, additional, Meissner, H. Cody, additional, Mejias, Asuncion, additional, Mertsola, Jussi, additional, Messacar, Kevin, additional, Mhaissen, Mohammad Nael, additional, Michaels, Marian G., additional, Miller, Melissa B., additional, Miller-Handley, Hilary, additional, Mintz, Eric, additional, Mohan, Parvathi, additional, Montgomery, Susan P., additional, Montoya, Jose G., additional, Moorman, Anne C., additional, Moro, Pedro L., additional, Moscicki, Anna-Barbara, additional, Muller, William J., additional, Myers, Angela L., additional, Nadel, Simon, additional, Nayak, Jennifer Lynn, additional, Neely, Michael Noel, additional, Neil, Karen P., additional, Nelson, Christina A., additional, Nelson, Noele P., additional, Nichols, Megin, additional, Nicholson, William, additional, Nopper, Amy Jo, additional, Norton, Laura E., additional, Ochoa, Theresa J., additional, Olarte, Liset, additional, Onarecker, Timothy R., additional, Orenstein, Walter A., additional, ORyan, Miguel, additional, Otto, William R., additional, Ouellette, Christopher P., additional, Paddock, Christopher D., additional, Palazzi, Debra L., additional, Panuganti, Suresh Kumar, additional, Pappas, Diane E., additional, Paret, Michal, additional, Pastula, Daniel M., additional, Patterson, Thomas F., additional, Petersen, Brett W., additional, Petrosyan, Mikael, additional, Pickering, Larry K., additional, Pindyck, Talia, additional, Pinninti, Swetha, additional, Pittet, Laure F., additional, Planet, Paul J., additional, Pollard, Andrew J., additional, Posfay-Barbe, Klara M., additional, Poulsen, Casper S., additional, Poutanen, Susan M., additional, Powers, Ann M., additional, Prasanphanich, Nina Salinger, additional, Pritt, Bobbi S., additional, Prober, Charles G., additional, Puar, Neha, additional, Quilter, Laura A.S., additional, Ramilo, Octavio, additional, Rao, Suchitra, additional, Ratner, Adam J., additional, Rawstron, Sarah A., additional, Read, Jennifer S., additional, Relich, Ryan F., additional, Reller, Megan E., additional, Robinson, Candice L., additional, Romero, Jos R., additional, Rosen, David A., additional, Ross, Shannon A., additional, Rours, G. Ingrid J.G., additional, Rowe, Peter C., additional, Rowley, Anne H., additional, Rubin, Lorry G., additional, Ryan, Edward T., additional, Sacharok, Alexandra, additional, Sandora, Thomas J., additional, Sapp, Sarah G.H., additional, Sardana, Kabir, additional, Sauberan, Jason B., additional, Schaffzin, Joshua K., additional, Schillie, Sarah, additional, Schuster, Jennifer E., additional, Schwartz, Kevin L., additional, Sederdahl, Bethany K., additional, Serpa-Alvarez, Jose, additional, Shah, Kara N., additional, Shah, Samir S., additional, Shaikh, Nader, additional, Shane, Andi L., additional, Shapiro, Eugene D., additional, Shaw, Jana, additional, Shetty, Avinash K., additional, Shope, Timothy R., additional, Dairiki Shortliffe, Linda M., additional, Shulman, Stanford T., additional, Shust, Gail F., additional, Siberry, George Kelly, additional, Siegel, Jane D., additional, Siegel, Robert David, additional, Simonsen, Kari A., additional, Singh, Upinder, additional, Smith, Christiana, additional, Smith, Lauren L., additional, Song, Eunkyung, additional, Souder, Emily, additional, Spearman, Paul, additional, St. Geme, Joseph W., additional, Staat, Mary Allen, additional, Staples, J. Erin, additional, Starke, Jeffrey R., additional, Statler, Victoria A., additional, Steinbach, William J., additional, Stensvold, Christen Rune, additional, Stokes, Erin K., additional, Stoner, Bradley P., additional, Storch, Gregory A., additional, Straily, Anne, additional, Sullivan, Kathleen E., additional, Swanson, Douglas S., additional, Tanz, Robert R., additional, Taormina, Gillian, additional, Tate, Jacqueline E., additional, Taveras, Jeanette, additional, Tebruegge, Marc, additional, Teshale, Eyasu H., additional, Thompson, George R., additional, Thompson-Stone, Robert, additional, Thomsen, Isaac, additional, Thomson, Richard B., additional, Thorell, Emily A., additional, Tien, Vivian, additional, Tobin, Nicole H., additional, Toltzis, Philip, additional, Treat, James, additional, Troy, Stephanie B., additional, Van Dvke, Russell B., additional, Vaz, Louise Elaine, additional, Vijayan, Vini, additional, Vodzak, Jennifer, additional, Wagner, Thor A., additional, Wald, Ellen R., additional, Wallihan, Rebecca, additional, Wang, Huanyu, additional, Wangu, Zoon, additional, Washam, Matthew, additional, Waters, Valerie, additional, Watson, Joshua R., additional, Weatherhead, Jill E., additional, Weinberg, Geoffrey A., additional, Weng, Mark K., additional, Wiederhold, Nathan P., additional, Wiesenfeld, Harold C., additional, Williams, Cydni, additional, Williams, John V., additional, Willoughby, Rodney E., additional, Wittler, Robert R., additional, Wood, James B., additional, Woods, Charles Reece, additional, Workowski, Kimberly A., additional, Wright, Terry W., additional, Wu, Hsi-Yang, additional, Xu, Huan, additional, Yagupsky, Pablo, additional, Yi, Jumi, additional, Yoder, Jonathan, additional, Young, Edward J., additional, Zaenglein, Andrea L., additional, Zimmermann, Petra, additional, and Zong, Wenjing, additional more...
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- 2023
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5. Defining elimination as a public health problem for schistosomiasis control programmes: beyond prevalence of heavy-intensity infections
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Wiegand, Ryan E, Fleming, Fiona M, de Vlas, Sake J, Odiere, Maurice R, Kinung'hi, Safari, King, Charles H, Evans, Darin, French, Michael D, Montgomery, Susan P, Straily, Anne, Utzinger, Jürg, Vounatsou, Penelope, and Secor, W Evan more...
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- 2022
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6. Seroprevalence and Risk Factors for Toxoplasma gondii Infection in Women of Reproductive Age in Nigeria in 2018.
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Blackburn, Dawn, Mba, Nwando, Nwachukwu, William, Hong Zhou, Hill, Andrew, Abbott, Andrew, Parameswaran, Nishanth, Awala, Samuel, Greby, Stacie, Alagi, Matthias, Iriemenam, Nnaemeka C., Okoye, McPaul I., Swaminathan, Mahesh, Priest, Jeffrey W., Martin, Diana, Straily, Anne, and Ihekweazu, Chikwe more...
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- 2024
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7. Epidemiologic and Genomic Evidence for Zoonotic Transmission of SARS-CoV-2 among People and Animals on a Michigan Mink Farm, United States, 2020
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Ria R. Ghai, Anne Straily, Nora Wineland, Jennifer Calogero, Mary Grace Stobierski, Kimberly Signs, Melissa Blievernicht, Yaritbel Torres-Mendoza, Michelle A. Waltenburg, Jillian A. Condrey, Heather M. Blankenship, Diana Riner, Nancy Barr, Michele Schalow, Jarold Goodrich, Cheryl Collins, Ausaf Ahmad, John Michael Metz, Owen Herzegh, Kelly Straka, Dustin M. Arsnoe, Anthony G. Duffiney, Susan A. Shriner, Markus H. Kainulainen, Ann Carpenter, Florence Whitehill, Natalie M. Wendling, Robyn A. Stoddard, Adam C. Retchless, Anna Uehara, Ying Tao, Yan Li, Jing Zhang, Suxiang Tong, and Casey Barton Behravesh more...
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SARS-CoV-2 ,COVID-19 ,coronavirus ,zoonotic disease ,animal ,mink ,Microbiology ,QR1-502 - Abstract
Farmed mink are one of few animals in which infection with SARS-CoV-2 has resulted in sustained transmission among a population and spillback from mink to people. In September 2020, mink on a Michigan farm exhibited increased morbidity and mortality rates due to confirmed SARS-CoV-2 infection. We conducted an epidemiologic investigation to identify the source of initial mink exposure, assess the degree of spread within the facility’s overall mink population, and evaluate the risk of further viral spread on the farm and in surrounding wildlife habitats. Three farm employees reported symptoms consistent with COVID-19 the same day that increased mortality rates were observed among the mink herd. One of these individuals, and another asymptomatic employee, tested positive for SARS-CoV-2 by real-time reverse transcription PCR (RT-qPCR) 9 days later. All but one mink sampled on the farm were positive for SARS-CoV-2 based on nucleic acid detection from at least one oral, nasal, or rectal swab tested by RT-qPCR (99%). Sequence analysis showed high degrees of similarity between sequences from mink and the two positive farm employees. Epidemiologic and genomic data, including the presence of F486L and N501T mutations believed to arise through mink adaptation, support the hypothesis that the two employees with SARS-CoV-2 nucleic acid detection contracted COVID-19 from mink. However, the specific source of virus introduction onto the farm was not identified. Three companion animals living with mink farm employees and 31 wild animals of six species sampled in the surrounding area were negative for SARS-CoV-2 by RT-qPCR. Results from this investigation support the necessity of a One Health approach to manage the zoonotic spread of SARS-CoV-2 and underscores the critical need for multifaceted public health approaches to prevent the introduction and spread of respiratory viruses on mink farms. more...
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- 2023
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8. Éclosions de trichinellose humaine — Arizona, Minnesota et Dakota du Sud, 2022
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Cash-Goldwasser, Shama, primary, Ortbahn, Dustin, additional, Narayan, Muthu, additional, Fitzgerald, Conor, additional, Maldonado, Keila, additional, Currie, James, additional, Straily, Anne, additional, Sapp, Sarah, additional, Bishop, Henry S, additional, Watson, Billy, additional, Neja, Margaret, additional, Qvarnstrom, Yvonne, additional, Berman, David M, additional, Park, Sarah Y, additional, Smith, Kirk, additional, and Holzbauer, Stacy, additional more...
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- 2024
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9. Epidemiologic and Genomic Evidence for Zoonotic Transmission of SARS-CoV-2 among People and Animals on a Michigan Mink Farm, United States, 2020
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Ghai, Ria R., primary, Straily, Anne, additional, Wineland, Nora, additional, Calogero, Jennifer, additional, Stobierski, Mary Grace, additional, Signs, Kimberly, additional, Blievernicht, Melissa, additional, Torres-Mendoza, Yaritbel, additional, Waltenburg, Michelle A., additional, Condrey, Jillian A., additional, Blankenship, Heather M., additional, Riner, Diana, additional, Barr, Nancy, additional, Schalow, Michele, additional, Goodrich, Jarold, additional, Collins, Cheryl, additional, Ahmad, Ausaf, additional, Metz, John Michael, additional, Herzegh, Owen, additional, Straka, Kelly, additional, Arsnoe, Dustin M., additional, Duffiney, Anthony G., additional, Shriner, Susan A., additional, Kainulainen, Markus H., additional, Carpenter, Ann, additional, Whitehill, Florence, additional, Wendling, Natalie M., additional, Stoddard, Robyn A., additional, Retchless, Adam C., additional, Uehara, Anna, additional, Tao, Ying, additional, Li, Yan, additional, Zhang, Jing, additional, Tong, Suxiang, additional, and Barton Behravesh, Casey, additional more...
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- 2023
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10. 624. Outbreak of Human Trichinellosis Linked to Bear Meat Infected with Multiple Trichinella Species — Arizona, Minnesota, and South Dakota, 2022
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Cash-Goldwasser, Shama, primary, Ortbahn, Dustin, additional, Narayan, Muthu, additional, Fitzgerald, Conor, additional, Maldonado, Keila, additional, Straily, Anne, additional, Sapp, Sarah, additional, Watson, Billy, additional, Qvarnstrom, Yvonne, additional, Margaret, Neja, additional, Berman, David, additional, Park, Sarah Y, additional, Smith, Kirk, additional, and Holzbauer, Stacy, additional more...
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- 2023
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11. Schistosomiasis Seroprevalence among Children Aged 0–14 Years in Nigeria, 2018
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Straily, Anne, primary, Tamunonengiyeofori, Israel, additional, Wiegand, Ryan E., additional, Iriemenam, Nnaemeka C., additional, Okoye, McPaul I., additional, Dawurung, Ayuba B., additional, Ugboaja, Nkechi Blessing, additional, Tongha, Martha, additional, Parameswaran, Nishanth, additional, Greby, Stacie M., additional, Alagi, Matthias, additional, Akpan, Nseobong M., additional, Nwachukwu, William E., additional, Mba, Nwando, additional, Martin, Diana L., additional, Secor, W. Evan, additional, Swaminathan, Mahesh, additional, Adetifa, Ifedayo, additional, and Ihekweazu, Chikwe, additional more...
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- 2023
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12. Multiple Cyclosporiasis Outbreaks — United States, 2018
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Casillas, Shannon M., Bennett, Carolyne, and Straily, Anne
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- 2018
13. Chagas Disease Surveillance Activities — Seven States, 2017
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Bennett, Carolyne, Straily, Anne, Haselow, Dirk, Weinstein, Susan, Taffner, Richard, Yaglom, Hayley, Komatsu, Kenneth, Venkat, Heather, Brown, Catherine, Byers, Paul, Dunn, John, Moncayo, Abelardo, Mayes, Bonny C., and Montgomery, Susan P. more...
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- 2018
14. Cyclosporiasis Cases Associated with Dining at a Mediterranean-Style Restaurant Chain — Texas, 2017
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Keaton, Amelia A., Hall, Noemi Borsay, Chancey, Rebecca J., Heines, Vivienne, Cantu, Venessa, Vakil, Varsha, Long, Stephen, Short, Kirstin, Franciscus, Elya, Wahab, Natasha, Haynie, Aisha, Gieraltowski, Laura, and Straily, Anne more...
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- 2018
15. Trichinellosis Outbreak Linked to Consumption of Privately Raised Raw Boar Meat — California, 2017
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Heaton, Dustin, Huang, Sandra, Shiau, Rita, Casillas, Shannon, Straily, Anne, Kong, Li Kuo, Ng, Valerie, and Petru, Viviana
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- 2018
16. Urogenital schistosomiasis infection prevalence targets to determine elimination as a public health problem based on microhematuria prevalence in school-age children.
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Ryan E Wiegand, Fiona M Fleming, Anne Straily, Susan P Montgomery, Sake J de Vlas, Jürg Utzinger, Penelope Vounatsou, and W Evan Secor
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Arctic medicine. Tropical medicine ,RC955-962 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundRecent research suggests that schistosomiasis targets for morbidity control and elimination as a public health problem could benefit from a reanalysis. These analyses would define evidence-based targets that control programs could use to confidently assert that they had controlled or eliminated schistosomiasis as a public health problem. We estimated how low Schistosoma haematobium infection levels diagnosed by urine filtration in school-age children should be decreased so that microhematuria prevalence was at, or below, a "background" level of morbidity.MethodologyData obtained from school-age children in Burkina Faso, Mali, Niger, Tanzania, and Zambia who participated in schistosomiasis monitoring and evaluation cohorts were reanalyzed before and after initiation of preventive chemotherapy. Bayesian models estimated the infection level prevalence probabilities associated with microhematuria thresholds ≤10%, 13%, or 15%.Principal findingsAn infection prevalence of 5% could be a sensible target for urogenital schistosomiasis morbidity control in children as microhematuria prevalence was highly likely to be below 10% in all surveys. Targets of 8% and 11% infection prevalence were highly likely to result in microhematuria levels less than 13% and 15%, respectively. By contrast, measuring heavy-intensity infections only achieves these thresholds at impractically low prevalence levels.Conclusions/significanceA target of 5%, 8%, or 11% urogenital schistosomiasis infection prevalence in school-age children could be used to determine whether a geographic area has controlled or eliminated schistosomiasis as a public health problem depending on the local background threshold of microhematuria. more...
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- 2021
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17. Surveillance for Q Fever Endocarditis in the United States, 1999–2015
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Straily, Anne, Dahlgren, F. Scott, Peterson, Amy, and Paddock, Christopher D.
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- 2017
18. Toxoplasmosis
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Straily, A., primary
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- 2020
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19. Cyclospora cayetanensis comprises at least 3 species that cause human cyclosporiasis
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Joel Leonard Nicholas Barratt, John Shen, Katelyn Houghton, Travis Richins, Sarah G. H. Sapp, Vitaliano Cama, Michael J. Arrowood, Anne Straily, and Yvonne Qvarnstrom
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Infectious Diseases ,Animal Science and Zoology ,Parasitology - Abstract
The apicomplexan parasite Cyclospora cayetanensis causes seasonal foodborne outbreaks of the gastrointestinal illness cyclosporiasis. Prior to the coronavirus disease-2019 pandemic, annually reported cases were increasing in the USA, leading the US Centers for Disease Control and Prevention to develop a genotyping tool to complement cyclosporiasis outbreak investigations. Thousands of US isolates and 1 from China (strain CHN_HEN01) were genotyped by Illumina amplicon sequencing, revealing 2 lineages (A and B). The allelic composition of isolates was examined at each locus. Two nuclear loci (CDS3 and 360i2) distinguished lineages A and B. CDS3 had 2 major alleles: 1 almost exclusive to lineage A and the other to lineage B. Six 360i2 alleles were observed – 2 exclusive to lineage A (alleles A1 and A2), 2 to lineage B (B1 and B2) and 1 (B4) was exclusive to CHN_HEN01 which shared allele B3 with lineage B. Examination of heterozygous genotypes revealed that mixtures of A- and B-type 360i2 alleles occurred rarely, suggesting a lack of gene flow between lineages. Phylogenetic analysis of loci from whole-genome shotgun sequences, mitochondrial and apicoplast genomes, revealed that CHN_HEN01 represents a distinct lineage (C). Retrospective examination of epidemiologic data revealed associations between lineage and the geographical distribution of US infections plus strong temporal associations. Given the multiple lines of evidence for speciation within human-infecting Cyclospora, we provide an updated taxonomic description of C. cayetanensis, and describe 2 novel species as aetiological agents of human cyclosporiasis: Cyclospora ashfordi sp. nov. and Cyclospora henanensis sp. nov. (Apicomplexa: Eimeriidae). more...
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- 2022
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20. One Health Investigation of SARS-CoV-2 Infection and Seropositivity among Pets in Households with Confirmed Human COVID-19 Cases—Utah and Wisconsin, 2020
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Grace W. Goryoka, Caitlin M. Cossaboom, Radhika Gharpure, Patrick Dawson, Cassandra Tansey, John Rossow, Victoria Mrotz, Jane Rooney, Mia Torchetti, Christina M. Loiacono, Mary L. Killian, Melinda Jenkins-Moore, Ailam Lim, Keith Poulsen, Dan Christensen, Emma Sweet, Dallin Peterson, Anna L. Sangster, Erin L. Young, Kelly F. Oakeson, Dean Taylor, Amanda Price, Tair Kiphibane, Rachel Klos, Darlene Konkle, Sanjib Bhattacharyya, Trivikram Dasu, Victoria T. Chu, Nathaniel M. Lewis, Krista Queen, Jing Zhang, Anna Uehara, Elizabeth A. Dietrich, Suxiang Tong, Hannah L. Kirking, Jeffrey B. Doty, Laura S. Murrell, Jessica R. Spengler, Anne Straily, Ryan Wallace, and Casey Barton Behravesh more...
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COVID-19 ,SARS-CoV-2 ,pets ,dog ,cat ,transmission ,Microbiology ,QR1-502 - Abstract
Approximately 67% of U.S. households have pets. Limited data are available on SARS-CoV-2 in pets. We assessed SARS-CoV-2 infection in pets during a COVID-19 household transmission investigation. Pets from households with ≥1 person with laboratory-confirmed COVID-19 were eligible for inclusion from April–May 2020. We enrolled 37 dogs and 19 cats from 34 households. All oropharyngeal, nasal, and rectal swabs tested negative by rRT-PCR; one dog’s fur swabs (2%) tested positive by rRT-PCR at the first sampling. Among 47 pets with serological results, eight (17%) pets (four dogs, four cats) from 6/30 (20%) households had detectable SARS-CoV-2 neutralizing antibodies. In households with a seropositive pet, the proportion of people with laboratory-confirmed COVID-19 was greater (median 79%; range: 40–100%) compared to households with no seropositive pet (median 37%; range: 13–100%) (p = 0.01). Thirty-three pets with serologic results had frequent daily contact (≥1 h) with the index patient before the person’s COVID-19 diagnosis. Of these 33 pets, 14 (42%) had decreased contact with the index patient after diagnosis and none were seropositive; of the 19 (58%) pets with continued contact, four (21%) were seropositive. Seropositive pets likely acquired infection after contact with people with COVID-19. People with COVID-19 should restrict contact with pets and other animals. more...
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- 2021
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21. Defining elimination as a public health problem for schistosomiasis control programmes
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Ryan E Wiegand, Fiona M Fleming, Sake J de Vlas, Maurice R Odiere, Safari Kinung'hi, Charles H King, Darin Evans, Michael D French, Susan P Montgomery, Anne Straily, Jürg Utzinger, Penelope Vounatsou, and W Evan Secor more...
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Cross-Sectional Studies ,SDG 3 - Good Health and Well-being ,Prevalence ,Schistosoma haematobium ,Animals ,Humans ,Schistosomiasis ,General Medicine ,Public Health ,Article - Abstract
WHO's 2021-30 road map for neglected tropical diseases (NTDs) outlines disease-specific and cross-cutting targets for the control, elimination, and eradication of NTDs in affected countries. For schistosomiasis, the criterion for elimination as a public health problem (EPHP) is defined as less than 1% prevalence of heavy-intensity infections (ie, ≥50 Schistosoma haematobium eggs per 10 mL of urine or ≥400 Schistosoma mansoni eggs per g of stool). However, we believe the evidence supporting this definition of EPHP is inadequate and the shifting distribution of schistosomiasis morbidity towards more subtle, rather than severe, morbidity in the face of large-scale control programmes requires guidelines to be adapted. In this Viewpoint, we outline the need for more accurate measures to develop a robust evidence-based monitoring and evaluation framework for schistosomiasis. Such a framework is crucial for achieving the goal of widespread EPHP of schistosomiasis and to meet the WHO road map targets. We encourage use of overall prevalence of schistosome infection (instead of the prevalence of heavy-intensity infections), development of species-dependent and age-dependent morbidity markers, and construction of a standardised monitoring and evaluation protocol. more...
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- 2022
22. Retrospective Evaluation of an Integrated Molecular-Epidemiological Approach to Cyclosporiasis Outbreak Investigations — United States, 2021
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Ahart, Lauren, primary, Jacobson, David, additional, Rice, Marion, additional, Richins, Travis, additional, Peterson, Anna, additional, Zheng, Yueli, additional, Barratt, Joel, additional, Cama, Vitaliano, additional, Qvarnstrom, Yvonne, additional, Montgomery, Susan, additional, and Straily, Anne, additional more...
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- 2023
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23. Community-Based Prevention of Rocky Mountain Spotted Fever — Sonora, Mexico, 2016
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Straily, Anne, Drexler, Naomi, Cruz-Loustaunau, Denica, Paddock, Christopher D., and Alvarez-Hernandez, Gerardo
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- 2016
24. Rickettsia parkeri Rickettsiosis — Georgia, 2012–2014
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Straily, Anne, Feldpausch, Amanda, Ulbrich, Carl, Schell, Kiersten, Casillas, Shannon, Zaki, Sherif R., Denison, Amy M., Condit, Marah, Gabel, Julie, and Paddock, Christopher D.
- Published
- 2016
25. Public Health Surveillance and Reporting for Human Toxoplasmosis--Six States, 2021
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McCall, Jayden, Rothfeldt, Laura, Giesbrecht, Kelly, Hunt, Amanda, Bauck, Leah, Scheftel, Joni, Birn, Rachael, Buss, Bryan, Schroeder, Betsy, Haupt, Thomas E., Klos, Rachel, and Straily, Anne
- Subjects
Toxoplasmosis -- Surveys ,Infection -- Surveys ,Zoonoses -- Surveys ,Public health -- Surveys ,Health - Abstract
Toxoplasmosis is caused by infection with the zoonotic parasite Toxoplasma gondii. Although disease tends to be mild (e.g., self-limiting influenza-like symptoms) or asymptomatic in immunocompetent persons, toxoplasmosis is more severe [...] more...
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- 2022
26. Retrospective evaluation of an integrated molecular-epidemiological approach to cyclosporiasis outbreak investigations - United States, 2021.
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Ahart, L, Jacobson, D, Rice, M, Richins, T, Peterson, A, Zheng, Y, Barratt, J, Cama, V, Qvarnstrom, Y, Montgomery, S, Straily, A, Ahart, L, Jacobson, D, Rice, M, Richins, T, Peterson, A, Zheng, Y, Barratt, J, Cama, V, Qvarnstrom, Y, Montgomery, S, and Straily, A more...
- Abstract
Cyclosporiasis results from an infection of the small intestine by Cyclospora parasites after ingestion of contaminated food or water, often leading to gastrointestinal distress. Recent developments in temporally linking genetically related Cyclospora isolates demonstrated effectiveness in supporting epidemiological investigations. We used 'temporal-genetic clusters' (TGCs) to investigate reported cyclosporiasis cases in the United States during the 2021 peak-period (1 May - 31 August 2021). Our approach split 655 genotyped isolates into 55 genetic clusters and 31 TGCs. We linked two large multi-state epidemiological clusters (Epidemiologic Cluster 1 [n = 136 cases, 54 genotyped] and Epidemiologic Cluster 2 [n = 42 cases, 15 genotyped]) to consumption of lettuce varieties; however, product traceback did not identify a specific product for either cluster due to the lack of detailed product information. To evaluate the utility of TGCs, we performed a retrospective case study comparing investigation outcomes of outbreaks first detected using epidemiological methods with those of the same outbreaks had TGCs been used to first detect them. Our study results indicate that adjustments to routine epidemiological approaches could link additional cases to epidemiological clusters of cyclosporiasis. Overall, we show that CDC's integrated genotyping and epidemiological investigations provide valuable insights into cyclosporiasis outbreaks in the United States. more...
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- 2023
27. Evaluation of the Point-of-Care Circulating Cathodic Antigen Assay for Monitoring Mass Drug Administration in a Schistosoma mansoni Control Program in Western Kenya
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Dollycate Wanja, Ryan E. Wiegand, Emmy A. Kavere, Susan P. Montgomery, Alex Mwaki, Alie Eleveld, William Evan Secor, Maurice R. Odiere, and Anne Straily
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medicine.medical_specialty ,Concordance ,Point-of-Care Systems ,Schistosomiasis ,Urine ,Article ,Praziquantel ,Feces ,Virology ,Internal medicine ,parasitic diseases ,medicine ,Prevalence ,Animals ,Humans ,Mass drug administration ,Point of care ,Anthelmintics ,biology ,business.industry ,Schistosoma mansoni ,biology.organism_classification ,medicine.disease ,Kenya ,Schistosomiasis mansoni ,Infectious Diseases ,Antigens, Helminth ,Mass Drug Administration ,Parasitology ,business ,medicine.drug - Abstract
The WHO guidelines for monitoring and evaluating Schistosoma mansoni control programs are based on the Kato-Katz (KK) fecal examination method; however, there are limitations to its use, particularly in low prevalence areas. The point-of-care urine circulating cathodic antigen (POC-CCA) assay has emerged as a useful tool for mapping schistosomiasis prevalence, but its use in monitoring and evaluating control programs has not been evaluated. Before POC-CCA can be used for these programs, it must be determined how previous guidance based on the KK method can be translated to the POC-CCA assay; furthermore, its performance in different endemicity settings must be evaluated. Urine and stool specimens were collected from students attending public primary schools in western Kenya before mass treatment with praziquantel at baseline (51 schools), year 1 (45 schools), year 2 (34 schools), and year 3 (20 schools). Prevalence and infection intensity were determined by the KK method and POC-CCA assay. Changes in prevalence and intensity were compared within the strata of schools grouped according to the baseline prevalence determined by the KK method (0–10%, > 10–20%, > 20%). The prevalence determined by the POC-CCA assay was higher than that determined by the KK method at all time points for all strata. The prevalence determined by the KK method decreased from baseline to 2 and 3 years, as did infection intensity (with one exception). A corresponding decrease was not always replicated by the POC-CCA assay results. The POC-CCA assay did not perform as expected, and the concordance of results of the two tests was poor. Furthermore, there are emerging concerns regarding the specificity of the POC-CCA assay. Therefore, it is impossible to translate historical data and programmatic guidelines based on the KK method results to the POC-CCA assay. more...
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- 2021
28. Contributors
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Mark J. Abzug, Elisabeth E. Adderson, Aastha Agarwal, Allison L. Agwu, Lindsey Albenberg, Jonathan Albert, Kevin Alby, Grace M. Aldrovandi, Upton D. Allen, Gerardo Alvarez-Hernndez, Krow Ampofo, Evan J. Anderson, Grace D. Appiah, Monica I. Ardura, Stephen S. Arnon, Naomi E. Aronson, Ann M. Arvin, Shai Ashkenazi, Liat Ashkenazi-Hoffnung, Edwin J. Asturias, Kestutis Aukstuolis, Vahe Badalyan, Carol J. Baker, Karthik Balakrishnan, Elizabeth D. Barnett, Kirsten Bechtel, William E. Benitz, Rachel Berkovich, David M. Berman, Stephanie R. Bialek, Else M. Bijker, Matthew J. Bizzarro, Karen C. Bloch, Joseph A. Bocchini, Thomas G. Boyce, John S. Bradley, Denise F. Bratcher, Paula K. Braverman, Itzhak Brook, Kevin Edward Brown, Kristina P. Bryant, Andres F. Camacho-Gonzalez, Connie F. Caete-Gibas, Joseph B. Cantey, Paul Cantey, Cristina V. Cardemil, Mary T. Caserta, Luis A. Castagnini, Jessica R. Cataldi, Ellen Gould Chadwick, Rebecca J. Chancey, Cara C. Cherry, Silvia S. Chiang, Mary Choi, John C. Christenson, Susan E. Coffin, Amanda Cohn, Despina G. Contopoulos-Ioannidis, James H. Conway, Margaret M. Cortese, C. Buddy Creech, Jonathan D. Crews, Donna Curtis, Nigel Curtis, Lara A. Danziger-Isakov, Toni Darville, Gregory A. Dasch, Irini Daskalaki, H. Dele Davies, Fatimah S. Dawood, J. Christopher Day, M. Teresa de la Morena, Gregory P. DeMuri, Dickson D. Despommier, Daniel S. Dodson, Stephen J. Dolgner, Clinton Dunn, Jonathan Dyal, Kathryn M. Edwards, Morven S. Edwards, Dawn Z. Eichenfield, Lawrence F. Eichenfield, Dirk M. Elston, Beth Emerson, Leslie A. Enane, Moshe Ephros, Guliz Erdem, Marina E. Eremeeva, Douglas H. Esposito, Monica M. Farley, Anat R. Feingold, Kristina N. Feja, Adam Finn, Marc Fischer, Brian T. Fisher, Randall G. Fisher, Patricia Michele Flynn, Monique A. Foster, LeAnne M. Fox, Michael M. Frank, Douglas R. Fredrick, Robert W. Frenck, James Gaensbauer, Hayley A. Gans, Gregory M. Gauthier, Patrick Gavigan, Jeffrey S. Gerber, Yael Gernez, Francis Gigliotti, Mark A. Gilger, Carol A. Glaser, Jane M. Gould, James Graziano, Amanda M. Green, Michael Green, Daniel Griffin, Patricia M. Griffin, David C. Griffith, Piyush Gupta, Bruce J. Gutelius, Julie R. Gutman, Aron J. Hall, Rana F. Hamdy, Jin-Young Han, Lori K. Handy, Benjamin Hanisch, Marvin B. Harper, Aaron M. Harris, Christopher J. Harrison, David B. Haslam, Julia C. Haston, Sarah.J. Hawkes, Taylor Heald-Sargent, J. Owen Hendley, Adam L. Hersh, Joseph A. Hilinski, Susan L. Hills, David K. Hong, Peter J. Hotez, Katherine K. Hsu, Felicia Scaggs Huang, David A. Hunstad, W. Garrett Hunt, Loris Y. Hwang, Christelle M. Ilboudo, Preeti Jaggi, Sophonie Jean, Ravi Jhaveri, Kateina Jirk-Pomajbkov, Nadia A. Kadry, Mary L. Kamb, Ronak K. Kapadia, Ben Z. Katz, Sophie E. Katz, Ishminder Kaur, Gilbert J. Kersh, Muhammad Ali Khan, Ananta Khurana, David W. Kimberlin, Bruce Klein, Miwako Kobayashi, Larry K. Kociolek, Andrew Y. Koh, Karen L. Kotloff, Andrew T. Kroger, Matthew P. Kronman, Leah Lalor, Christine T. Lauren, Amy Leber, Eyal Leshem, David B. Lewis, Robyn A. Livingston, Eloisa Llata, Kevin Lloyd, Katrina Loh, Sarah S. Long, Benjamin A. Lopman, Yalda C. Lucero, Debra J. Lugo, Jorge Lujn-Zilbermann, Yvonne A. Maldonado, John J. Manaloor, Kalpana Manthiram, Stacey W. Martin, Roshni Mathew, Tony Mazzulli, Elizabeth J. McFarland, Kathleen A. McGann, Lucy A. McNamara, Debrah Meislich, H. Cody Meissner, Asuncion Mejias, Jussi Mertsola, Kevin Messacar, Mohammad Nael Mhaissen, Marian G. Michaels, Melissa B. Miller, Hilary Miller-Handley, Eric Mintz, Parvathi Mohan, Susan P. Montgomery, Jose G. Montoya, Anne C. Moorman, Pedro L. Moro, Anna-Barbara Moscicki, William J. Muller, Angela L. Myers, Simon Nadel, Jennifer Lynn Nayak, Michael Noel Neely, Karen P. Neil, Christina A. Nelson, Noele P. Nelson, Megin Nichols, William Nicholson, Amy Jo Nopper, Laura E. Norton, Theresa J. Ochoa, Liset Olarte, Timothy R. Onarecker, Walter A. Orenstein, Miguel ORyan, William R. Otto, Christopher P. Ouellette, Christopher D. Paddock, Debra L. Palazzi, Suresh Kumar Panuganti, Diane E. Pappas, Michal Paret, Daniel M. Pastula, Thomas F. Patterson, Brett W. Petersen, Mikael Petrosyan, Larry K. Pickering, Talia Pindyck, Swetha Pinninti, Laure F. Pittet, Paul J. Planet, Andrew J. Pollard, Klara M. Posfay-Barbe, Casper S. Poulsen, Susan M. Poutanen, Ann M. Powers, Nina Salinger Prasanphanich, Bobbi S. Pritt, Charles G. Prober, Neha Puar, Laura A.S. Quilter, Octavio Ramilo, Suchitra Rao, Adam J. Ratner, Sarah A. Rawstron, Jennifer S. Read, Ryan F. Relich, Megan E. Reller, Candice L. Robinson, Jos R. Romero, David A. Rosen, Shannon A. Ross, G. Ingrid J.G. Rours, Peter C. Rowe, Anne H. Rowley, Lorry G. Rubin, Edward T. Ryan, Alexandra Sacharok, Thomas J. Sandora, Sarah G.H. Sapp, Kabir Sardana, Jason B. Sauberan, Joshua K. Schaffzin, Sarah Schillie, Jennifer E. Schuster, Kevin L. Schwartz, Bethany K. Sederdahl, Jose Serpa-Alvarez, Kara N. Shah, Samir S. Shah, Nader Shaikh, Andi L. Shane, Eugene D. Shapiro, Jana Shaw, Avinash K. Shetty, Timothy R. Shope, Linda M. Dairiki Shortliffe, Stanford T. Shulman, Gail F. Shust, George Kelly Siberry, Jane D. Siegel, Robert David Siegel, Kari A. Simonsen, Upinder Singh, Christiana Smith, Lauren L. Smith, Eunkyung Song, Emily Souder, Paul Spearman, Joseph W. St. Geme, Mary Allen Staat, J. Erin Staples, Jeffrey R. Starke, Victoria A. Statler, William J. Steinbach, Christen Rune Stensvold, Erin K. Stokes, Bradley P. Stoner, Gregory A. Storch, Anne Straily, Kathleen E. Sullivan, Douglas S. Swanson, Robert R. Tanz, Gillian Taormina, Jacqueline E. Tate, Jeanette Taveras, Marc Tebruegge, Eyasu H. Teshale, George R. Thompson, Robert Thompson-Stone, Isaac Thomsen, Richard B. Thomson, Emily A. Thorell, Vivian Tien, Nicole H. Tobin, Philip Toltzis, James Treat, Stephanie B. Troy, Russell B. Van Dvke, Louise Elaine Vaz, Vini Vijayan, Jennifer Vodzak, Thor A. Wagner, Ellen R. Wald, Rebecca Wallihan, Huanyu Wang, Zoon Wangu, Matthew Washam, Valerie Waters, Joshua R. Watson, Jill E. Weatherhead, Geoffrey A. Weinberg, Mark K. Weng, Nathan P. Wiederhold, Harold C. Wiesenfeld, Cydni Williams, John V. Williams, Rodney E. Willoughby, Robert R. Wittler, James B. Wood, Charles Reece Woods, Kimberly A. Workowski, Terry W. Wright, Hsi-Yang Wu, Huan Xu, Pablo Yagupsky, Jumi Yi, Jonathan Yoder, Edward J. Young, Andrea L. Zaenglein, Petra Zimmermann, and Wenjing Zong more...
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- 2023
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29. Cyclospora cayetanensis comprises at least 3 species that cause human cyclosporiasis
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Barratt, Joel Leonard Nicholas, primary, Shen, John, additional, Houghton, Katelyn, additional, Richins, Travis, additional, Sapp, Sarah G. H., additional, Cama, Vitaliano, additional, Arrowood, Michael J., additional, Straily, Anne, additional, and Qvarnstrom, Yvonne, additional more...
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- 2022
- Full Text
- View/download PDF
30. 285 - Blood Trematodes: Schistosomiasis
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Montgomery, Susan P. and Straily, Anne
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- 2023
- Full Text
- View/download PDF
31. Association between water, sanitation and hygiene factors, and soil transmitted helminth infection
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Velleman, Yael, Braun, Laura, Straily, Anne, and Secor, William
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helminths ,sanitation ,water ,whipworm ,NTDs ,Diseases ,parasites ,roundworm ,hygiene ,strongyloides ,WASH ,Medicine and Health Sciences ,Parasitic Diseases ,soil transmitted helminths ,STH ,hookworm - Abstract
A scoping review of literature published from 2014 onwards outlining and quantifying the association between exposures related to water, sanitation and hygiene conditions, and infections with soil-transmitted helminths. more...
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- 2022
- Full Text
- View/download PDF
32. Association between water, sanitation and hygiene factors, and schistosomiasis infection
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Velleman, Yael, Straily, Anne, Secor, William, and Braun, Laura
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helminths ,elimination ,parasitic disease ,WASH ,bilharzia ,schistosomiasis ,Medicine and Health Sciences ,Life Sciences ,Public Health - Abstract
A scoping review of literature published from 2014 onwards outlining and quantifying the association between exposures related to water, sanitation and hygiene conditions, and infections with schistosomes. more...
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- 2022
- Full Text
- View/download PDF
33. Toxoplasmosis Outbreak Associated With Toxoplasma gondii-Contaminated Venison—High Attack Rate, Unusual Clinical Presentation, and Atypical Genotype
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Kristine M. Bisgard, Carlos A. Gomez, Cindy Press, Dolores E. Hill, Karine Passebosc-Faure, Amy C Schumacher, Jose G. Montoya, Lina I Elbadawi, Marie-Laure Dardé, Traci DeSalvo, Stephanie Smiley, James J Kazmierczak, Anne Straily, Daniel Ajzenberg, David Letzer, Ellen Moldenhauer, Christelle Pomares, Tammy L Handly, Centers for Disease Control and Prevention [Atlanta] (CDC), Centers for Disease Control and Prevention, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de Référence (CNR) Toxoplasmose/Toxoplasma Biological Resource Center (BRC) (CNR Toxoplasmose-Toxoplasma BRC), and CHU Limoges more...
- Subjects
Male ,Microbiology (medical) ,Pediatrics ,medicine.medical_specialty ,Meat ,Genotype ,030231 tropical medicine ,Attack rate ,Toxoplasma gondii ,Asymptomatic ,Article ,Disease Outbreaks ,Serology ,03 medical and health sciences ,Wisconsin ,0302 clinical medicine ,medicine ,Animals ,Humans ,0303 health sciences ,biology ,030306 microbiology ,business.industry ,Incidence ,Outbreak ,Middle Aged ,medicine.disease ,biology.organism_classification ,Toxoplasmosis ,3. Good health ,Toxoplasmosis, Animal ,Infectious Diseases ,North America ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Chills ,medicine.symptom ,Genetic characterization ,business ,Toxoplasma ,Polymorphism, Restriction Fragment Length - Abstract
Background During 2017, in response to a physician’s report, the Wisconsin Department of Health Services, Division of Public Health, began investigating an outbreak of febrile illness among attendees of a retreat where never frozen, intentionally undercooked, locally harvested venison was served. Preliminary testing tentatively identified the illness as toxoplasmosis. Methods Confirmatory human serology panels and testing of the venison to confirm and categorize the presence and type of Toxoplasma gondii were completed by French and American national reference laboratories. All 12 retreat attendees were interviewed; medical records were reviewed. Results All attendees were male; median age was 51 years (range: 22–75). After a median incubation period of 7 days, 9 (82%) of 11 exposed persons experienced illness lasting a median of 12 days. All 9 sought outpatient healthcare for symptoms including fever, chills, sweats, and headache (100%) and ocular disturbances (33%). Testing confirmed the illness as toxoplasmosis and venison as the infection source. Multiple laboratory results were atypical for toxoplasmosis, including transaminitis (86%), lymphocytopenia (88%), thrombocytopenia (38%), and leukopenia (63%). One exposed but asymptomatic person was seronegative; the other had immunity from prior infection. The T. gondii strain was identified as closely related to an atypical genotype (haplogroup 12, polymerase chain reaction restriction fragment length polymorphism genotype 5) common in North American wildlife but with previously uncharacterized human clinical manifestations. Conclusions The T. gondii strain contaminating the venison might explain the unusual clinical presentations. In North America, clinicians and venison consumers should be aware of risk for severe or unusual presentations of acute toxoplasmosis after consuming undercooked game meat. more...
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- 2020
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34. Corrigendum to: Toxoplasmosis Outbreak Associated With Toxoplasma gondii-Contaminated Venison—High Attack Rate, Unusual Clinical Presentation, and Atypical Genotype
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Amy C Schumacher, Lina I Elbadawi, Traci DeSalvo, Anne Straily, Daniel Ajzenberg, David Letzer, Ellen Moldenhauer, Tammy L Handly, Dolores Hill, Marie-Laure Dardé, Christelle Pomares, Karine Passebosc-Faure, Kristine Bisgard, Carlos A Gomez, Cindy Press, Stephanie Smiley, José G Montoya, James J Kazmierczak, Centers for Disease Control and Prevention [Atlanta] (CDC), Centers for Disease Control and Prevention, Wisconsin Division of Public Health, Service de Parasitologie Mycologie [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Animal Parasitic Diseases Laboratory [Beltsville, USA], United States Department of Agriculture (USDA)-USDA Agricultural Research Service [Beltsville, Maryland], USDA-ARS : Agricultural Research Service-USDA-ARS : Agricultural Research Service, Laboratoire de Parasitologie-Mycologie, Nice, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Université Côte d'Azur (UCA), Centre méditerranéen de médecine moléculaire (C3M), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), and University of Utah School of Medicine [Salt Lake City] more...
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Microbiology (medical) ,Infectious Diseases ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience; No abstract available
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- 2022
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35. Genotyping Cyclospora cayetanensis from multiple outbreak clusters with an emphasis on a cluster linked to bagged salad mix - United States, 2020.
- Author
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Barratt, J, Ahart, L, Rice, M, Houghton, K, Richins, T, Cama, V, Arrowood, M, Qvarnstrom, Y, Straily, A, Barratt, J, Ahart, L, Rice, M, Houghton, K, Richins, T, Cama, V, Arrowood, M, Qvarnstrom, Y, and Straily, A more...
- Abstract
Cyclosporiasis is a diarrheal illness caused by the food-borne parasite Cyclospora cayetanensis. Annually reported cases have been increasing in the United States prompting development of genotyping tools to aid cluster detection. A recently developed Cyclospora genotyping system based on eight genetic markers was applied to clinical samples collected during the cyclosporiasis peak-period of 2020, facilitating assessment of its epidemiologic utility. While the system performed well and helped inform epidemiological investigations, inclusion of additional markers to improve cluster detection was supported. Consequently, investigations have commenced to identify additional markers to enhance performance. more...
- Published
- 2022
36. Defining elimination as a public health problem for schistosomiasis control programmes:beyond prevalence of heavy-intensity infections
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Wiegand, Ryan E., Fleming, Fiona M., de Vlas, Sake J., Odiere, Maurice R., Kinung'hi, Safari, King, Charles H., Evans, Darin, French, Michael D., Montgomery, Susan P., Straily, Anne, Utzinger, Jürg, Vounatsou, Penelope, Secor, W. Evan, Wiegand, Ryan E., Fleming, Fiona M., de Vlas, Sake J., Odiere, Maurice R., Kinung'hi, Safari, King, Charles H., Evans, Darin, French, Michael D., Montgomery, Susan P., Straily, Anne, Utzinger, Jürg, Vounatsou, Penelope, and Secor, W. Evan more...
- Abstract
WHO's 2021–30 road map for neglected tropical diseases (NTDs) outlines disease-specific and cross-cutting targets for the control, elimination, and eradication of NTDs in affected countries. For schistosomiasis, the criterion for elimination as a public health problem (EPHP) is defined as less than 1% prevalence of heavy-intensity infections (ie, ≥50 Schistosoma haematobium eggs per 10 mL of urine or ≥400 Schistosoma mansoni eggs per g of stool). However, we believe the evidence supporting this definition of EPHP is inadequate and the shifting distribution of schistosomiasis morbidity towards more subtle, rather than severe, morbidity in the face of large-scale control programmes requires guidelines to be adapted. In this Viewpoint, we outline the need for more accurate measures to develop a robust evidence-based monitoring and evaluation framework for schistosomiasis. Such a framework is crucial for achieving the goal of widespread EPHP of schistosomiasis and to meet the WHO road map targets. We encourage use of overall prevalence of schistosome infection (instead of the prevalence of heavy-intensity infections), development of species-dependent and age-dependent morbidity markers, and construction of a standardised monitoring and evaluation protocol. more...
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- 2022
37. Corrigendum to: Toxoplasmosis Outbreak Associated With Toxoplasma gondii-Contaminated Venison—High Attack Rate, Unusual Clinical Presentation, and Atypical Genotype
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Schumacher, Amy C, primary, Elbadawi, Lina I, additional, DeSalvo, Traci, additional, Straily, Anne, additional, Ajzenberg, Daniel, additional, Letzer, David, additional, Moldenhauer, Ellen, additional, Handly, Tammy L, additional, Hill, Dolores, additional, Dardé, Marie-Laure, additional, Pomares, Christelle, additional, Passebosc-Faure, Karine, additional, Bisgard, Kristine, additional, Gomez, Carlos A, additional, Press, Cindy, additional, Smiley, Stephanie, additional, Montoya, José G, additional, and Kazmierczak, James J, additional more...
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- 2022
- Full Text
- View/download PDF
38. Cyclospora cayetanensis comprises at least 3 species that cause human cyclosporiasis.
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Barratt, Joel Leonard Nicholas, Shen, John, Houghton, Katelyn, Richins, Travis, Sapp, Sarah G. H., Cama, Vitaliano, Arrowood, Michael J., Straily, Anne, and Qvarnstrom, Yvonne
- Subjects
SHOTGUN sequencing ,CORONAVIRUSES ,SARS-CoV-2 ,GENE flow ,SPECIES ,COVID-19 pandemic ,ALLELES - Abstract
The apicomplexan parasite Cyclospora cayetanensis causes seasonal foodborne outbreaks of the gastrointestinal illness cyclosporiasis. Prior to the coronavirus disease-2019 pandemic, annually reported cases were increasing in the USA, leading the US Centers for Disease Control and Prevention to develop a genotyping tool to complement cyclosporiasis outbreak investigations. Thousands of US isolates and 1 from China (strain CHN_HEN01) were genotyped by Illumina amplicon sequencing, revealing 2 lineages (A and B). The allelic composition of isolates was examined at each locus. Two nuclear loci (CDS3 and 360i2) distinguished lineages A and B. CDS3 had 2 major alleles: 1 almost exclusive to lineage A and the other to lineage B. Six 360i2 alleles were observed – 2 exclusive to lineage A (alleles A1 and A2), 2 to lineage B (B1 and B2) and 1 (B4) was exclusive to CHN_HEN01 which shared allele B3 with lineage B. Examination of heterozygous genotypes revealed that mixtures of A- and B-type 360i2 alleles occurred rarely, suggesting a lack of gene flow between lineages. Phylogenetic analysis of loci from whole-genome shotgun sequences, mitochondrial and apicoplast genomes, revealed that CHN_HEN01 represents a distinct lineage (C). Retrospective examination of epidemiologic data revealed associations between lineage and the geographical distribution of US infections plus strong temporal associations. Given the multiple lines of evidence for speciation within human-infecting Cyclospora , we provide an updated taxonomic description of C. cayetanensis , and describe 2 novel species as aetiological agents of human cyclosporiasis: Cyclospora ashfordi sp. nov. and Cyclospora henanensis sp. nov. (Apicomplexa: Eimeriidae). [ABSTRACT FROM AUTHOR] more...
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- 2023
- Full Text
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39. Genotyping Cyclospora cayetanensis from multiple outbreak clusters with an emphasis on a cluster linked to bagged salad mix - United States, 2020
- Author
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Barratt, J, Ahart, L, Rice, M, Houghton, K, Richins, T, Cama, V, Arrowood, M, Qvarnstrom, Y, and Straily, A
- Subjects
Genotype ,06 Biological Sciences, 11 Medical and Health Sciences ,Humans ,Salads ,Cyclosporiasis ,Microbiology ,United States ,Cyclospora ,Disease Outbreaks - Abstract
Cyclosporiasis is a diarrheal illness caused by the food-borne parasite Cyclospora cayetanensis. Annually reported cases have been increasing in the United States prompting development of genotyping tools to aid cluster detection. A recently developed Cyclospora genotyping system based on eight genetic markers was applied to clinical samples collected during the cyclosporiasis peak-period of 2020, facilitating assessment of its epidemiologic utility. While the system performed well and helped inform epidemiological investigations, inclusion of additional markers to improve cluster detection was supported. Consequently, investigations have commenced to identify additional markers to enhance performance. more...
- Published
- 2021
40. Neglected Parasitic Infections: What Family Physicians Need to Know-A CDC Update
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Paul T, Cantey, Susan P, Montgomery, and Anne, Straily
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Family Health ,Cysticercosis ,Carrier State ,Cats ,Parasitic Diseases ,Animals ,Humans ,Chagas Disease ,Centers for Disease Control and Prevention, U.S ,Toxoplasmosis ,United States - Abstract
Chagas disease, cysticercosis, and toxoplasmosis affect millions of people in the United States and are considered neglected parasitic diseases. Few resources are devoted to their surveillance, prevention, and treatment. Chagas disease, transmitted by kissing bugs, primarily affects people who have lived in Mexico, Central America, and South America, and it can cause heart disease and death if not treated. Chagas disease is diagnosed by detecting the parasite in blood or by serology, depending on the phase of disease. Antiparasitic treatment is indicated for most patients with acute disease. Treatment for chronic disease is recommended for people younger than 18 years and generally recommended for adults younger than 50 years. Treatment decisions should be individualized for all other patients. Cysticercosis can manifest in muscles, the eyes, and most critically in the brain (neurocysticercosis). Neurocysticercosis accounts for 2.1% of all emergency department visits for seizures in the United States. Diagnosing neurocysticercosis involves serology and neuroimaging. Treatment includes symptom control and antiparasitic therapy. Toxoplasmosis is estimated to affect 11% of people older than six years in the United States. It can be acquired by ingesting food or water that has been contaminated by cat feces; it can also be acquired by eating undercooked, contaminated meat. Toxoplasma infection is usually asymptomatic; however, people who are immunosuppressed can develop more severe neurologic symptoms. Congenital infection can result in miscarriage or adverse fetal effects. Diagnosis is made with serologic testing, polymerase chain reaction testing, or parasite detection in tissue or fluid specimens. Treatment is recommended for people who are immunosuppressed, pregnant patients with recently acquired infection, and people who are immunocompetent with visceral disease or severe symptoms. more...
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- 2021
41. Investigation of US
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Joel, Barratt, Katelyn, Houghton, Travis, Richins, Anne, Straily, Ryan, Threlkel, Betelehem, Bera, Jayne, Kenneally, Brooke, Clemons, Susan, Madison-Antenucci, Elizabeth, Cebelinski, Brooke M, Whitney, Katherine R, Kreil, Vitaliano, Cama, Michael J, Arrowood, and Yvonne, Qvarnstrom more...
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cyclosporiasis ,Molecular Epidemiology ,Original Paper ,Genotype ,Genotyping Techniques ,outbreak ,Clinical Laboratory Techniques ,Cyclospora cayetanensis ,DNA, Protozoan ,United States ,Cyclospora ,Disease Outbreaks ,Feces ,genotyping ,Cluster Analysis ,Humans ,clusters ,Cyclosporiasis - Abstract
Cyclosporiasis is an illness characterised by watery diarrhoea caused by the food-borne parasite Cyclospora cayetanensis. The increase in annual US cyclosporiasis cases led public health agencies to develop genotyping tools that aid outbreak investigations. A team at the Centers for Disease Control and Prevention (CDC) developed a system based on deep amplicon sequencing and machine learning, for detecting genetically-related clusters of cyclosporiasis to aid epidemiologic investigations. An evaluation of this system during 2018 supported its robustness, indicating that it possessed sufficient utility to warrant further evaluation. However, the earliest version of CDC's system had some limitations from a bioinformatics standpoint. Namely, reliance on proprietary software, the inability to detect novel haplotypes and absence of a strategy to select an appropriate number of discrete genetic clusters would limit the system's future deployment potential. We recently introduced several improvements that address these limitations and the aim of this study was to reassess the system's performance to ensure that the changes introduced had no observable negative impacts. Comparison of epidemiologically-defined cyclosporiasis clusters from 2019 to analogous genetic clusters detected using CDC's improved system reaffirmed its excellent sensitivity (90%) and specificity (99%), and confirmed its high discriminatory power. This C. cayetanensis genotyping system is robust and with ongoing improvement will form the basis of a US-wide C. cayetanensis genotyping network for clinical specimens. more...
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- 2021
42. Investigation of US Cyclospora cayetanensis outbreaks in 2019 and evaluation of an improved Cyclospora genotyping system against 2019 cyclosporiasis outbreak clusters
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Barratt, J, Houghton, K, Richins, T, Straily, A, Threlkel, R, Bera, B, Kenneally, J, Clemons, B, Madison-Antenucci, S, Cebelinski, E, Whitney, BM, Kreil, KR, Cama, V, Arrowood, MJ, and Qvarnstrom, Y
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Molecular Epidemiology ,Genotype ,Genotyping Techniques ,Epidemiology ,Clinical Laboratory Techniques ,DNA, Protozoan ,United States ,1117 Public Health and Health Services ,Cyclospora ,Disease Outbreaks ,Feces ,Cluster Analysis ,Humans ,Cyclosporiasis - Abstract
Cyclosporiasis is an illness characterised by watery diarrhoea caused by the food-borne parasite Cyclospora cayetanensis. The increase in annual US cyclosporiasis cases led public health agencies to develop genotyping tools that aid outbreak investigations. A team at the Centers for Disease Control and Prevention (CDC) developed a system based on deep amplicon sequencing and machine learning, for detecting genetically-related clusters of cyclosporiasis to aid epidemiologic investigations. An evaluation of this system during 2018 supported its robustness, indicating that it possessed sufficient utility to warrant further evaluation. However, the earliest version of CDC's system had some limitations from a bioinformatics standpoint. Namely, reliance on proprietary software, the inability to detect novel haplotypes and absence of a strategy to select an appropriate number of discrete genetic clusters would limit the system's future deployment potential. We recently introduced several improvements that address these limitations and the aim of this study was to reassess the system's performance to ensure that the changes introduced had no observable negative impacts. Comparison of epidemiologically-defined cyclosporiasis clusters from 2019 to analogous genetic clusters detected using CDC's improved system reaffirmed its excellent sensitivity (90%) and specificity (99%), and confirmed its high discriminatory power. This C. cayetanensis genotyping system is robust and with ongoing improvement will form the basis of a US-wide C. cayetanensis genotyping network for clinical specimens. more...
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- 2021
43. One Health Investigation of SARS-CoV-2 Infection and Seropositivity among Pets in Households with Confirmed Human COVID-19 Cases—Utah and Wisconsin, 2020
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Trivikram Dasu, Amanda J. Price, Krista Queen, Christina M. Loiacono, Dallin Peterson, Dean Taylor, Suxiang Tong, Laura S Murrell, Casey Barton Behravesh, Emma Sweet, Jeffrey B. Doty, Nathaniel M. Lewis, Caitlin M. Cossaboom, John Rossow, Grace W Goryoka, Ailam Lim, Kelly F. Oakeson, Ryan M. Wallace, Anne Straily, Keith P. Poulsen, Mary Lea Killian, Anna L Sangster, Mia Kim Torchetti, Radhika Gharpure, Victoria T Chu, Jing Zhang, Hannah L Kirking, Anna Uehara, Patrick Dawson, Jessica R. Spengler, Dan Ploug Christensen, Tair Kiphibane, Sanjib Bhattacharyya, Melinda Jenkins-Moore, Jane Rooney, Rachel Klos, Elizabeth A. Dietrich, Victoria Mrotz, Erin L Young, Cassandra Tansey, and Darlene Konkle more...
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2019-20 coronavirus outbreak ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,cat ,History, 21st Century ,Viral Zoonoses ,Microbiology ,Article ,Serology ,Dogs ,Wisconsin ,Seroepidemiologic Studies ,Virology ,Internal medicine ,Utah ,household transmission ,Medicine ,Animals ,Humans ,Phylogeny ,Family Characteristics ,business.industry ,Transmission (medicine) ,SARS-CoV-2 ,Family characteristics ,transmission ,COVID-19 ,QR1-502 ,zoonoses ,Infectious Diseases ,One Health ,Population Surveillance ,dog ,Cats ,RNA, Viral ,pets ,business - Abstract
Approximately 67% of U.S. households have pets. Limited data are available on SARS-CoV-2 in pets. We assessed SARS-CoV-2 infection in pets during a COVID-19 household transmission investigation. Pets from households with ≥1 person with laboratory-confirmed COVID-19 were eligible for inclusion from April–May 2020. We enrolled 37 dogs and 19 cats from 34 households. All oropharyngeal, nasal, and rectal swabs tested negative by rRT-PCR, one dog’s fur swabs (2%) tested positive by rRT-PCR at the first sampling. Among 47 pets with serological results, eight (17%) pets (four dogs, four cats) from 6/30 (20%) households had detectable SARS-CoV-2 neutralizing antibodies. In households with a seropositive pet, the proportion of people with laboratory-confirmed COVID-19 was greater (median 79%, range: 40–100%) compared to households with no seropositive pet (median 37%, range: 13–100%) (p = 0.01). Thirty-three pets with serologic results had frequent daily contact (≥1 h) with the index patient before the person’s COVID-19 diagnosis. Of these 33 pets, 14 (42%) had decreased contact with the index patient after diagnosis and none were seropositive, of the 19 (58%) pets with continued contact, four (21%) were seropositive. Seropositive pets likely acquired infection after contact with people with COVID-19. People with COVID-19 should restrict contact with pets and other animals. more...
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- 2021
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44. Evaluation of the Point-of-Care Circulating Cathodic Antigen Assay for Monitoring Mass Drug Administration in a Schistosoma mansoni Control Program in Western Kenya
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Straily, Anne, primary, Kavere, Emmy A., additional, Wanja, Dollycate, additional, Wiegand, Ryan E., additional, Montgomery, Susan P., additional, Mwaki, Alex, additional, Eleveld, Alie, additional, Secor, William E., additional, and Odiere, Maurice R., additional more...
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- 2021
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45. Community-based prevention of epidemic Rocky Mountain spotted fever among minority populations in Sonora, Mexico, using a One Health approach
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Naomi A. Drexler, Vanessa A Arteaga-Cardenas, Jesús D. Licona-Enriquez, Anne Straily, Christopher D. Paddock, Jesús Delgado-de la Mora, Gerardo Álvarez-Hernández, Maria del Carmen Candia-Plata, and Denica Cruz-Loustaunau more...
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medicine.medical_specialty ,biology ,Community based prevention ,Acaricide ,Rocky Mountain spotted fever ,Public health ,Public Health, Environmental and Occupational Health ,Psychological intervention ,Outbreak ,Rhipicephalus sanguineus ,General Medicine ,Tick ,medicine.disease ,biology.organism_classification ,Dogs ,Infectious Diseases ,One Health ,medicine ,Animals ,Parasitology ,Epidemics ,Mexico ,Rocky Mountain Spotted Fever ,Demography - Abstract
Background Rocky Mountain spotted fever (RMSF) is a significant public health problem in Sonora, Mexico, resulting in thousands of cases and hundreds of deaths. Outbreaks of RMSF are perpetuated by heavy brown dog tick infestations in and around homes. During 2009–2015, there were 61 RMSF cases and 23 deaths in a single community of Sonora (Community A). Methods An integrated intervention was carried out from March–November 2016 aimed at reducing tick populations with long-acting acaricidal collars on dogs, environmental acaricides applied to peri-domestic areas and RMSF education. Tick levels were measured by inspection of community dogs to monitor efficacy of the intervention. A similar neighborhood (Community B) was selected for comparison and received standard care (acaricide treatment and education). Results The prevalence of tick-infested dogs in Community A declined from 32.5% to 8.8% (p Conclusions Community-based interventions using an integrated approach to control brown dog ticks can diminish the morbidity and mortality attributable to RMSF. more...
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- 2019
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46. Genotyping Cyclospora cayetanensis From Multiple Outbreak Clusters With An Emphasis on a Cluster Linked to Bagged Salad Mix-United States, 2020
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Lauren Ahart, Travis Richins, Joel Barratt, Michael J. Arrowood, Vitaliano Cama, Anne Straily, Katelyn Houghton, Marion E. Rice, and Yvonne Qvarnstrom
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Genotype ,Outbreak ,Biology ,biology.organism_classification ,Cyclospora cayetanensis ,United States ,Cyclospora ,Disease Outbreaks ,Infectious Diseases ,Environmental health ,Immunology and Allergy ,Humans ,Salads ,Cyclosporiasis ,Genotyping - Abstract
Cyclosporiasis is a diarrheal illness caused by the foodborne parasite Cyclospora cayetanensis. Annually reported cases have been increasing in the United States prompting development of genotyping tools to aid cluster detection. A recently developed Cyclospora genotyping system based on 8 genetic markers was applied to clinical samples collected during the cyclosporiasis peak period of 2020, facilitating assessment of its epidemiologic utility. While the system performed well and helped inform epidemiologic investigations, inclusion of additional markers to improve cluster detection was supported. Consequently, investigations have commenced to identify additional markers to enhance performance. more...
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- 2021
47. Genotyping Cyclospora cayetanensis From Multiple Outbreak Clusters With An Emphasis on a Cluster Linked to Bagged Salad Mix—United States, 2020
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Barratt, Joel, primary, Ahart, Lauren, additional, Rice, Marion, additional, Houghton, Katelyn, additional, Richins, Travis, additional, Cama, Vitaliano, additional, Arrowood, Michael, additional, Qvarnstrom, Yvonne, additional, and Straily, Anne, additional more...
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- 2021
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48. One Health Investigation of SARS-CoV-2 Infection and Seropositivity among Pets in Households with Confirmed Human COVID-19 Cases—Utah and Wisconsin, 2020
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Goryoka, Grace W., primary, Cossaboom, Caitlin M., additional, Gharpure, Radhika, additional, Dawson, Patrick, additional, Tansey, Cassandra, additional, Rossow, John, additional, Mrotz, Victoria, additional, Rooney, Jane, additional, Torchetti, Mia, additional, Loiacono, Christina M., additional, Killian, Mary L., additional, Jenkins-Moore, Melinda, additional, Lim, Ailam, additional, Poulsen, Keith, additional, Christensen, Dan, additional, Sweet, Emma, additional, Peterson, Dallin, additional, Sangster, Anna L., additional, Young, Erin L., additional, Oakeson, Kelly F., additional, Taylor, Dean, additional, Price, Amanda, additional, Kiphibane, Tair, additional, Klos, Rachel, additional, Konkle, Darlene, additional, Bhattacharyya, Sanjib, additional, Dasu, Trivikram, additional, Chu, Victoria T., additional, Lewis, Nathaniel M., additional, Queen, Krista, additional, Zhang, Jing, additional, Uehara, Anna, additional, Dietrich, Elizabeth A., additional, Tong, Suxiang, additional, Kirking, Hannah L., additional, Doty, Jeffrey B., additional, Murrell, Laura S., additional, Spengler, Jessica R., additional, Straily, Anne, additional, Wallace, Ryan, additional, and Barton Behravesh, Casey, additional more...
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- 2021
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49. One Health Investigation of SARS-CoV-2 Infection and Seropositivity among Pets in Households with Confirmed Human COVID-19 Cases — Utah and Wisconsin, 2020
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Erin L Young, Christina M. Loiacono, Caitlin M. Cossaboom, Krista Queen, Victoria T Chu, Tair Kiphibane, Grace W Goryoka, Elizabeth A. Dietrich, Melinda Jenkins-Moore, Jing Zhang, Casey Barton Behravesh, Cassandra Tansey, Anne Straily, Emma Sweet, Ailam Lim, Jessica R. Spengler, Sanjib Bhattacharyya, Keith P. Poulsen, Dan Ploug Christensen, Kelly F. Oakeson, Ryan M. Wallace, Anna L Sangster, Nathaniel M. Lewis, Mia Kim Torchetti, Dallin Peterson, Dean Taylor, John Rossow, Darlene Konkle, Rachel Klos, Trivikram Dasu, Anna Uehara, Patrick Dawson, Suxiang Tong, Amanda J. Price, Jeffrey B. Doty, Jane Rooney, Hannah L Kirking, Victoria Mrotz, Radhika Gharpure, Mary Lea Killian, and Laura S Murrell more...
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medicine.medical_specialty ,One Health ,Coronavirus disease 2019 (COVID-19) ,Transmission (medicine) ,business.industry ,Internal medicine ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,medicine ,Virus Neutralization ,business ,Disease control ,Feces ,Serology - Abstract
BackgroundApproximately 67% of U.S. households have pets. Limited data are available on SARS-CoV-2 in pets. We assessed SARS-CoV-2 infection in pet cohabitants as a sub-study of an ongoing COVID-19 household transmission investigation.MethodsMammalian pets from households with ≥1 person with laboratory-confirmed COVID-19 were eligible for inclusion from April–May 2020. Demographic/exposure information, oropharyngeal, nasal, rectal, and fur swabs, feces, and blood were collected from enrolled pets and tested by rRT-PCR and virus neutralization assays.FindingsWe enrolled 37 dogs and 19 cats from 34 of 41 eligible households. All oropharyngeal, nasal, and rectal swabs tested negative by rRT-PCR; one dog’s fur swabs (2%) tested positive by rRT-PCR at the first animal sampling. Among 47 pets with serological results from 30 households, eight (17%) pets (4 dogs, 4 cats) from 6 (20%) households had detectable SARS-CoV-2 neutralizing antibodies. In households with a seropositive pet, the proportion of people with laboratory-confirmed COVID-19 was greater (median 79%; range: 40–100%) compared to households with no seropositive pet (median 37%; range: 13–100%) (p=0.01). Thirty-three pets with serologic results had frequent daily contact (≥1 hour) with the human index patient before the person’s COVID-19 diagnosis. Of these 33 pets, 14 (42%) had decreased contact with the human index patient after diagnosis and none (0%) were seropositive; of the 19 (58%) pets with continued contact, 4 (21%) were seropositive.InterpretationsSeropositive pets likely acquired infection from humans, which may occur more frequently than previously recognized. People with COVID-19 should restrict contact with animals.FundingCenters for Disease Control and Prevention, U.S. Department of Agriculture more...
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- 2021
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50. Use of a tablet-based system to perform abdominal ultrasounds in a field investigation of schistosomiasis-related morbidity in western Kenya
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Susan P. Montgomery, Rono Kiplimo, Dollycate Wanja, William Evan Secor, Rose Aera, Solomon Mwangi, Maurice R. Odiere, Anne Straily, Sarah Mukire, Alfred O. Malit, Emmy A. Kavere, Ryan E. Wiegand, Caroline Momanyi, and Ashley A. Souza more...
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Radiography, Abdominal ,medicine.medical_specialty ,Intestinal schistosomiasis ,030231 tropical medicine ,MEDLINE ,Schistosomiasis ,Disease ,03 medical and health sciences ,0302 clinical medicine ,Disease severity ,Virology ,medicine ,Prevalence ,Humans ,Diagnosis, Computer-Assisted ,Intensive care medicine ,Ultrasonography ,business.industry ,Public health ,Tropical disease ,Articles ,medicine.disease ,Kenya ,Schistosomiasis mansoni ,Infectious Diseases ,Computers, Handheld ,Parasitology ,Public Health ,Morbidity ,business - Abstract
Chronic intestinal schistosomiasis can cause severe hepatosplenic disease and is a neglected tropical disease of public health importance in sub-Saharan Africa, including Kenya. Although the goal of control programs is to reduce morbidity, milestones for program performance focus on reductions in prevalence and intensity of infection, rather than actual measures of morbidity. Using ultrasound to measure hepatosplenic disease severity is an accepted method of determining schistosomiasis-related morbidity; however, ultrasound has not historically been considered a field-deployable tool because of equipment limitations and unavailability of expertise. A point-of-care tablet-based ultrasound system was used to perform abdominal ultrasounds in a field investigation of schistosomiasis-related morbidity in western Kenya; during the study, other pathologies and pregnancies were also identified via ultrasound, and participants referred to care. Recent technological advances may make it more feasible to implement ultrasound as part of a control program and can also offer important benefits to the community. more...
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- 2021
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