297 results on '"Strand C"'
Search Results
2. Rapid Chemiluminescent Imaging Behind Reflected Shock Waves
- Author
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Davidson, D. F., Tulgestke, A., Strand, C., Campbell, M. F., Troutman, V. A., Miller, V. A., Hanson, R. K., Ben-Dor, Gabi, editor, Sadot, Oren, editor, and Igra, Ozer, editor
- Published
- 2017
- Full Text
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3. A non-intrusive site investigation for a Geological Disposal Facility for radioactive waste
- Author
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Strand, C., primary, Canning, J., additional, Eastwell, D., additional, Rudling, C., additional, Purcell, K., additional, and Bartlett, R., additional
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- 2023
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4. High-sensitivity in situ QCLAS-based ammonia concentration sensor for high-temperature applications
- Author
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Peng, W. Y., Sur, R., Strand, C. L., Spearrin, R. M., Jeffries, J. B., and Hanson, R. K.
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- 2016
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5. High-speed OH* chemiluminescence imaging of ignition through a shock tube end-wall
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Troutman, V. A., Strand, C. L., Campbell, M. F., Tulgestke, A. M., Miller, V. A., Davidson, D. F., and Hanson, R. K.
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- 2016
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6. Understanding the current backlash against LGBTIQ+ rights through the lens of heteroactivism: A case study of the International Organization for the Family’s transnational norm diffusion on Twitter
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Strand Cecilia, Eriksson Åsa, and Svensson Jakob
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anti-gender ,digital media ,heteroactivism ,lgbtiq+ ,norm diffusion ,Communication. Mass media ,P87-96 - Abstract
A new generation of transnational anti-gender actors are framing themselves as human rights champions and protectors of the rights of the “natural family”. To better understand these actors’ norm diffusion, including their re-styling of anti-gender narratives in contemporary iterations of heteroactivism and its potential threat to LGBTIQ+ rights, in this article we analyse the social media tactics of a key transnational anti-gender actor: the International Organization for the Family (IOF). The analysis is focused on the organisation’s Twitter (now X) account and we draw on theories of network media logic, connective action, and connective emotions. Two periods of activism – the first a low-intensity period in 2021 and the second a high-intensity period in 2022 – were purposefully selected for the analysis. In this article, we identify differences between the two periods, noting that the period covering the flagship event, the World Congress of Families (WCF) in 2022, was markedly less LGBTIQ-hostile and adversarial than the first period. IOF thus appears to be inspired by heteroactivist frames during the WCF and abides by logic that should trigger user interaction and content spreading. The lack of interactions and engagement with IOF Twitter content in either period indicates the need for more research on which logics apply to anti-gender audiences. We discuss the findings and what they may imply in a context like Sweden, a country whose self-image as a global champion for women’s and LGBTIQ+ rights may make it ill-equipped to counter the onslaught of transnational actors’ norm entrepreneurial activities.
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- 2024
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7. High resolution MR anatomy of the subthalamic nucleus: Imaging at 9.4 T with histological validation
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Massey, L.A., Miranda, M.A., Zrinzo, L., Al-Helli, O., Parkes, H.G., Thornton, J.S., So, P.-W., White, M.J., Mancini, L., Strand, C., Holton, J.L., Hariz, M.I., Lees, A.J., Revesz, T., and Yousry, T.A.
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- 2012
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8. Drugs and Remedies
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Strand, C. Vibeke and Clark, Sharon R.
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- 1983
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9. Final Result of DIAL (NCI10089), Randomized Phase 2 trial of Varlilumab combined with Nivolumab in patients with relapsed/refractory aggressive B‐cell non‐Hodgkin lymphoma.
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Soekojo, C. Y., Yin, J., Kline, J., Lazaryan, A., Bartlett, N., Geethakumari, P. Ramakrishnan, Awan, F., Karmali, R., Hernandez‐Ilizaliturri, F. J., Shune, L., Lansigan, F., Reeder, C., Diefenbach, C., Sharon, E., Mikula, E., Strand, C., Postovalova, E., Kotlov, N., Zornikova, K., and Bagaev, A.
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NON-Hodgkin's lymphoma ,NIVOLUMAB - Abstract
Subgroup analysis of patients with confirmed prior CAR-T cell therapy showed similar ORR compared to overall cohort (5/33; 15%), not statistically different between arms; 3 responses were complete (Figure 1B). Final Result of DIAL (NCI10089), Randomized Phase 2 trial of Varlilumab combined with Nivolumab in patients with relapsed/refractory aggressive B-cell non-Hodgkin lymphoma B Introduction: b The prognosis for patients with relapsed or refractory aggressive B-cell non-Hodgkin lymphoma (r/r B-NHL) is poor. [Extracted from the article]
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- 2023
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10. High Resolution Meets High Efficiency with an Ultra-Wide-Tow Penta Source Solution in The Barents Sea
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Oukili, J., primary, Widmaier, M., additional, Roalkvam, C., additional, Strand, C., additional, Halbert, N., additional, and Baramony, O., additional
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- 2021
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11. Novel clinicopathological characteristics differentiate dementia with Lewy bodies from Parkinson’s disease dementia
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Hansen, D., primary, Ling, H., additional, Lashley, T., additional, Foley, J. A., additional, Strand, C., additional, Eid, T. M., additional, Holton, J. L., additional, and Warner, T. T., additional
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- 2020
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12. Heat shock does not induce tolerance to hyperoxia
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Strand, C., Warshaw, J. B., Snow, K., and Jacobs, H. C.
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- 1994
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13. Frontotemporal lobar degeneration with ubiquitin-only-immunoreactive neuronal changes: broadening the clinical picture to include progressive supranuclear palsy
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Paviour, D. C., Lees, A. J., Josephs, K. A., Ozawa, T., Ganguly, M., Strand, C., Godbolt, A., Howard, R. S., Revesz, T., and Holton, J. L.
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- 2004
14. Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule-binding repeat domains as demonstrated by new specific monoclonal antibodies
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de Silva, R., Lashley, T., Gibb, G., Hanger, D., Hope, A., Reid, A., Bandopadhyay, R., Utton, M., Strand, C., Jowett, T., Khan, N., Anderton, B., Wood, N., Holton, J., Revesz, T., and Lees, A.
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- 2003
15. Pathological, clinical and genetic heterogeneity in progressive supranuclear palsy
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Morris, H. R., Gibb, G., Katzenschlager, R., Wood, N. W., Hanger, D. P., Strand, C., Lashley, T., Daniel, S. E., Lees, A. J., Anderton, B. H., and Revesz, T.
- Published
- 2002
16. Dual-comb Spectroscopy in Shock Tubes: Mid-Infrared Microsecond-resolved Spectrometer
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Geiser, M., primary, Horvath, R., additional, Strand, C. L., additional, Pinkowski, N., additional, Ding, Y., additional, and Hanson, R. K., additional
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- 2019
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17. Dual-comb Measurements behind Reflected Shock Waves
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Pinkowski, N., primary, Strand, C., additional, Ding, Y., additional, Hanson, R., additional, Horvath, R., additional, and Geiser, M., additional
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- 2019
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18. Novel clinicopathological characteristics differentiate dementia with Lewy bodies from Parkinson's disease dementia.
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Hansen, D., Ling, H., Lashley, T., Foley, J. A., Strand, C., Eid, T. M., Holton, J. L., and Warner, T. T.
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LEWY body dementia ,PARKINSON'S disease ,DEMENTIA ,CEREBRAL amyloid angiopathy ,ALZHEIMER'S disease ,AMYLOID beta-protein precursor - Abstract
Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) known as Lewy body dementias have overlapping clinical and neuropathological features. Neuropathology in both includes combination of Lewy body and Alzheimer's disease (AD) pathology. Cerebral amyloid angiopathy (CAA), often seen in AD, is increasingly recognized for its association with dementia. Aims: This study investigated clinical and neuropathological differences between DLB and PDD. Methods: 52 PDD and 16 DLB cases from the Queen Square Brain Bank (QSBB) for Neurological disorders were included. Comprehensive clinical data of motor and cognitive features were obtained from medical records. Neuropathological assessment included examination of CAA, Lewy body and AD pathology. Results: CAA was more common in DLB than in PDD (P = 0.003). The severity of CAA was greater in DLB than in PDD (P = 0.009), with significantly higher CAA scores in the parietal lobe (P = 0.043), and the occipital lobe (P = 0.008), in DLB than in PDD. The highest CAA scores were observed in cases with APOE ε4/4 and ε2/4. Survival analysis showed worse prognosis in DLB, as DLB reached each clinical milestone sooner than PDD. Absence of dyskinesia in DLB is linked to the significantly lower lifetime cumulative dose of levodopa in comparison with PDD. Conclusions: This is the first study which identified prominent concurrent CAA pathology as a pathological substrate of DLB. More prominent CAA and rapid disease progression as measured by clinical milestones distinguish DLB from PDD. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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19. Multiphysics Analysis of CFRP Charpy Tests by varying Temperatures.
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Andleeb, Z., Strand, C., Malik, S., Hussain, G., Khawaja, H., Boiger, G., and Moatamedi, M.
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NOTCHED bar testing , *WOVEN composites , *MECHANICAL properties of condensed matter , *LOW temperatures , *YOUNG'S modulus - Abstract
Carbon Fiber Reinforced Polymer (CFRP) composites have emerged as a major class of structural materials that have a significant potential use as a substitute for metals in aerospace, marine, automotive, and architecture due to their higher-strength-to-weight-ratio. CFRP is well suited for various applications, but their mechanical properties such as 'low-velocity impact resistance' are not well studied. In this study, the low-velocity impact resistance of CFRP woven composite was investigated with the help of Charpy impact tests. The CFRP samples were tested at room temperature (22°C) and at low temperature (-20°C). The experimental results indicated about 10% drop in energy-absorbing capability of CFRP samples at low temperatures in comparison to room temperature. The experimental results obtained for the room temperature were validated through finite element simulations using ANSYS® Workbench Explicit Dynamics. The mesh sensitivity analysis was performed to improve the accuracy of the finite element model. The numerical results helped to narrow down on the CFRP material properties that changed with temperature drop. It was found at -20°C, orthotropic Elasticity (Young's moduli in three mutually perpendicular directions) increases for CFRP woven composite as compared to room temperature (22°C), however the CFRP become brittle and there is a significant drop in their toughness. The current outcomes are useful for applications using CFRP under impact loading at low temperatures. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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20. Exploring the putative role of kallikrein‐6, calpain‐1 and cathepsin‐D in the proteolytic degradation of α‐synuclein in multiple system atrophy
- Author
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Kiely, A. P., primary, Miners, J. S., additional, Courtney, R., additional, Strand, C., additional, Love, S., additional, and Holton, J. L., additional
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- 2018
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21. Spread Spectrum Sweep Strategy to Improve Operational Efficiency with Marine Vibrators
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Tenghamn, R., primary, Long, A., additional, Strand, C., additional, and Beitz, M., additional
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- 2018
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22. 9.4 T MR microscopy of the substantia nigra with pathological validation in controls and disease
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Massey, LA, primary, Miranda, MA, additional, Al-Helli, O, additional, Parkes, HG, additional, Thornton, JS, additional, So, P-W, additional, White, MJ, additional, Mancini, L, additional, Strand, C, additional, Holton, J, additional, Lees, AJ, additional, Revesz, T, additional, and Yousry, TA, additional
- Published
- 2017
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23. Exploring the putative role of kallikrein‐6, calpain‐1 and cathepsin‐D in the proteolytic degradation of α‐synuclein in multiple system atrophy.
- Author
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Kiely, A. P., Miners, J. S., Courtney, R., Strand, C., Love, S., and Holton, J. L.
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KALLIKREIN ,CALPAIN ,CATHEPSIN D ,PARKINSON'S disease ,LEWY body dementia ,MULTIPLE system atrophy - Abstract
Aims: There is evidence that accumulation of α‐synuclein (α‐syn) in Parkinson's disease (PD) and dementia with Lewy bodies (DLB) results from impaired removal of α‐syn rather than its overproduction. Kallikrein‐6 (KLK6), calpain‐1 (CAPN1) and cathepsin‐D (CTSD) are among a small number of proteases that cleave α‐syn and are dysregulated in PD and DLB. Our aim in this study was to determine whether protease activity is altered in another α‐synucleinopathy, multiple system atrophy (MSA), and might thereby modulate the regional distribution of α‐syn accumulation. Methods: mRNA and protein level and/or activity of KLK6, CAPN1 and CTSD were measured and assessed in relation to α‐syn load in multiple brain regions (posterior frontal cortex, caudate nucleus, putamen, occipital cortex, pontine base and cerebellar white matter), in MSA (n = 20) and age‐matched postmortem control tissue (n = 20). Results: CTSD activity was elevated in MSA in the pontine base and cerebellar white matter. KLK6 and CAPN1 levels were elevated in MSA in the putamen and cerebellar white matter. However, the activity or level of these proteolytic enzymes did not correlate with the regional distribution of α‐syn. Conclusions: Accumulation of α‐syn in MSA is not due to reduced activity of the proteases we have studied. We suggest that their upregulation is likely to be a compensatory response to increased α‐syn in MSA. [ABSTRACT FROM AUTHOR]
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- 2019
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24. Minimal disease activity for rheumatoid arthritis: A preliminary definition
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Wells, G. A., Boers, M., Shea, B., Brooks, P. M., Simon, L. S., Strand, C. V., Aletaha, D., Anderson, J. J., Bombardier, C., Dougados, M., Emery, P., Felson, D. T., Fransen, J., Furst, D. E., Hazes, J. M. W., Johnson, K. R., Kirwan, J. R., Landewé, R. B. M., Lassere, M. N. D., Michaud, K., Suarez-Almazor, M., Silman, A. J., Smolen, J. S., Heijde, D. M. F. M., Riel, P. L. C. M., Wolfe, F., Peter Tugwell, Rheumatology, and Other departments
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Pathogenesis and modulation of inflammation [N4i 1] ,Chronic inflammation and autoimmunity [UMCN 4.2] ,musculoskeletal diseases ,Arthritis, Rheumatoid ,Clinical Trials as Topic ,Treatment Outcome ,ROC Curve ,Evaluation of complex medical interventions [NCEBP 2] ,Outcome Assessment, Health Care ,Humans ,skin and connective tissue diseases ,Auto-immunity, transplantation and immunotherapy [N4i 4] ,Severity of Illness Index - Abstract
Contains fulltext : 48816.pdf (Publisher’s version ) (Closed access) Agreement on response criteria in rheumatoid arthritis (RA) has allowed better standardization and interpretation of clinical trial reports. With recent advances in therapy, the proportion of patients achieving a satisfactory state of minimal disease activity (MDA) is becoming a more important measure with which to compare different treatment strategies. The threshold for MDA is between high disease activity and remission and, by definition, anyone in remission will also be in MDA. True remission is still rare in RA; in addition, the American College of Rheumatology definition is difficult to apply in the context of trials. Participants at OMERACT 6 in 2002 agreed on a conceptual definition of minimal disease activity (MDA): "that state of disease activity deemed a useful target of treatment by both the patient and the physician, given current treatment possibilities and limitations." To prepare for a preliminary operational definition of MDA for use in clinical trials, we asked rheumatologists to assess 60 patient profiles describing real RA patients seen in routine clinical practice. Based on their responses, several candidate definitions for MDA were designed and discussed at the OMERACT 7 in 2004. Feedback from participants and additional on-site analyses in a cross-sectional database allowed the formulation of 2 preliminary, equivalent definitions of MDA: one based on the Disease Activity Score 28 (DAS28) index, and one based on meeting cutpoints in 5 out the 7 WHO/ILAR core set measures. Researchers applying these definitions first need to choose whether to use the DAS28 or the core set definition, because although each selects a similar proportion in a population, these are not always the same patients. In both MDA definitions, an initial decision node places all patients in MDA who have a tender joint count of 0 and a swollen joint count of 0, and an erythrocyte sedimentation rate (ESR) no greater than 10 mm. If this condition is not met: * The DAS28 definition places patients in MDA when DAS28 < or = 2.85; * The core set definition places patients in MDA when they meet 5 of 7 criteria: (1) Pain (0-10) < or = 2; (2) Swollen joint count (0-28) < or = 1; (3) Tender joint count (0-28) < or = 1; (4) Health Assessment Questionnaire (HAQ, 0-3) < or = 0.5; (5) Physician global assessment of disease activity (0-10) < or = 1.5; (6) Patient global assessment of disease activity (0-10) < or = 2; (7) ESR < or = 20. This set of 2 definitions gained approval of 73% of the attendees. These (and other) definitions will now be subject to further validation in other databases.
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- 2005
25. Photographs of MIT environments
- Author
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Brian J. Swift., Massachusetts Institute of Technology. Dept. of Architecture., Strand, C. Mark, Brian J. Swift., Massachusetts Institute of Technology. Dept. of Architecture., and Strand, C. Mark
- Abstract
Thesis (M.S.V.S.)--Massachusetts Institute of Technology, Dept. of Architecture, 1984., MICROFICHE COPY AVAILABLE IN ARCHIVES AND ROTCH., This thesis is based on an exhibition of 43 photographs shown in a visual thesis exhibition at the Creative Photography Gallery November 15-December 15, 1983. The photographs document MIT environments with special categories pertaining to equipment and artifacts, working environments and portraits. The project is essentially a creative rather than a research project. It was undertaken in four semesters beginning in the fall of 1982. The thesis is a catalog of the exhibition with project background and technical notes . Slides of the photographs may be seen in the Rotch Visual Collections Library, and prints may be seen at the MIT Museum. Five of the exhibition prints (1), (21), (22), (39) and (42) were purchased for the Hayden Gallery permanent collection., by C. Mark Strand., M.S.V.S.
- Published
- 2013
26. Study of Heart and Renal Protection (SHARP): Randomized trial to assess the effects of lowering low-density lipoprotein cholesterol among 9,438 patients with chronic kidney disease.
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Reaich R., Schouten D., Rashid H., Birtcher K., Cantu J., Tait C., Taun W., Fadem S., Das D., Khosla U., Brown C., Brown T., Buquing J., Cromwell H., Dickson N., Najimipour B., Robeson J., Tabibi W., Mulloy L., Bailey K., Burton B., Fall P., Jagadeesan M., Paulson W., Szerlip H., White J., Faulkner M., Adeleye O., Boatright D., Mensah D., Nwankwo U., Crutcher L., Cummings C., Floyd M., Putatunda B., Ross J., Sanford V., Thadani U., Haragsim L., Parker B., Rogan L., Thresher M., Turner J., Dworkin L., Mignano D., O'Mara A., Shemin D., Bakris G., Basta E., Chua D., Neri G., Ahmed I., Elliott W., Fondren L., Hasabou N., Khosla N., Mazin A., Riehle J., Kovesdy C., Mendoza J., Ahmadzadeh S., Iranmanesh A., Lewis M., Lu J., Benabe J., Gonzalez-Melendez E., Padilla B., Serrano J., Russ T., Athmann L., Funke L., Larson P., Roach D., Salveson B., Nogueira J., Hanes D., Hise M., Light P., Copland E., Fink J., Hakim M., Hough K., McMinn S., Weir M., Young C., Kershaw G., Hill I., White B., Plumb T., Florescu M., Groggel G., Martin M., Rao V., Denu-Ciocca C., Candiani C., Cooper J., Gordon B., Joy M., Kiser M., Lambeth C., Rosas S., Cochetti P., Robinson J., Schankel K., Teng H., Weise W., Geneidy A., Murray P., Solomon R., De Waal D., LaPointe S., Schoenknecht A., Campese V., Habashy M., Ananthakrisna R., Bedwani D., Fazli U., Fetrat M., Frampton Q., Kaldas B., Kazarian V., Pitts L., Sadeghi A., Yeasmin N., Young E., Fissell R., Belanger K., Ricci N., Farwell W., Bowman T., Dhingra R., Pesenson A., Ambrosino J., Chittamooru S., Kaufman J., Ramos M., Yap C., Nakhle S., Aligaen L., Duren D., Laine B., Moore S., Tuazon H., Coyne D., Audrain J., Bryant B., Dombek S., Freeman S., Klein P., Germain M., Berkowitz A., Bokhari A., Braden G., Diaz A., Greco B., Mulhern J., O'Shea M., Poindexter A., Poppel D., Ryan M., Sweet S., Ye J., Osterman J., Lin T., Mays B., Rizvi A., Sonnier C., Twining C., Wang S., Hix M., Schenck J., Baigent C., Landray M., Reith C., Dasgupta T., Emberson J., Herrington W., Lewis D., Mafham M., Collins R., Bray C., Chen Y., Baxter A., Young A., Hill M., Knott C., Cass A., Feldt-Rasmussen B., Fellstrom B., Grobbee R., Gronhagen-Riska C., Haas M., Holdaas H., Hooi L.S., Jiang L., Kasiske B., Krairittichai U., Levin A., Massy Z., Tesar V., Walker R., Wanner C., Wheeler D., Wiecek A., Majoni W., Simpson D., Strony J., Musliner T., Agodoa L., Armitage J., Chen Z., Craig J., De Zeeuw D., Gaziano M., Grimm R., Krane V., Neal B., Ophascharoensuk V., Pedersen T., Sleight P., Tobert J., Tomson C., Sandercock P., Keech A., Whelton P., Yusuf S., Peto R., Parish S., Dolph L., Bahu T., Booth-Davey E., Brewster A., Yau F., Denis E., Frederick K., Haywood D., Heineman J., Howard S., Jayne K., Madgwick Z., Michell S., Murphy K., Ning L., Nolan J., Nunn M., Roberts J., Wickman M., Bowman L., Bulbulia R., Haynes R., Rahimi K., Rahman N., Ait-Sadi R., Barton I., Zhu W., Clark S., Kourellias K., Radley M., Brown K., Worthing D., Coates G., Goodenough B., Lucas N., Carreras A., Currie R., Donaldson O., Fjalling E., Gallagher M., Gibson K., Goddard J., Healy J., Hones L., Jardine M., Kwong I., Merai M., Murray S., Perkovic V., Rendina A., Gallo K., Caron S., Carlson K., Foley K., Matzek S., Mewhort L., O'Donoghue S., Perel-Winkler A., Terins T., Nie Q., Yu H., Ge L., Hao D., Li L., Pang X., Wei X., Yan G., Certikova Chabova V., Holst H., Molvadgaard T., Munksgaard D., Peltonen Y., Liabeuf S., Lebel C., Ouabou L., Bauer B., Bergmann K., Beusch M., Cavitt D., Drechsler C., Dulau I., Hugen K., Kempf S., Kuchenmeister B., Pscheidl V., Schmiedeke D., Schwarz M., Speerschneider K., Stahl B., Lim B.C., Nadia H., Zishareena M.F., Vasuthavan S., Ganesapillai A.T., Yuen S., Grobbee D., Bobbink I., Groot K., Sikking I., Raley J., Colban M., Smerud K., Trygg N., Waagaard E., Westad H., Rotkegel S., Spiechowicz U., Domoradzka M., Gawlowska M., Flygar A., Odmark I., Pettersson A., Blackwood S., Barclay J., Benham J., Brown R., Cureton L., Jackson D., Kennedy I., Leaper C., Taylor A., Winter C., Wise C., Nash M., Taylor Bennett A., Donaldson D., Chalmers K., Corderoy H., Bartkoske M., Bjerk C., Camarena A., Herskovitz L., Heuer C., Levin J., Robinson R., Wicklund B., Bentzel D., Cohen S., Costa C., Scranton R., Auwardt R., Boyer M., Cogdell P., Menahem S., Sheldrake J., Mount P., Fraenkel M., Bisscheroux P., Dempester J., Gleeson P., Harris G., Holmes C., Hyett K., Linton A., Miach P., Booth D., Druce L., Mantha M., Borg E., Green S., Killen J., Lynch Y., Colquhoun D., Herzig K., Row G., Addison J., Asa J., Beatson G., Calvird D., Edmunds J., Ferreira-Jardim A., Gwynne A., Mackay D., McLoughlin L., Wightwick C., Williams L., Ferrari P., Barry J., Hodson S., Zakrzewska W., Meagher E., Mulcahy M., Parnham A., Carney S., Garvey L., Gillies A., Hayes S., Mathew M., Fassett R., Anderson L., Clingeleffer C., Curnock A., Mayne L., Richardson D., Smith M., Smith S., Suranyi M., Howlin K., Chow J., Cleland B., Rayment G., Spicer T., Wong J., Wong M., Packham D., Alison C., Fraser I., Mitchell J., Nagle J., Brown F., Ellery C., Monkhouse J., Nandkumar J., Reith-Myers L., Gray N., Cocks C., Courtney M., Hollett P., Johnston C., Larsen H., Pollock A., Stewart S., Styles G., Wyndham R., Fanning M., Gibson W., Jackson S., Mannering M., Mercado E., Oliphant R., Sud K., Ubera N., Wood C., Karrasch J., Brinkley T., Estensen K., Moroney A., Sutton J., Warren R., Saltissi D., Jahke H., Roach H., Saltissi J., Wiederroth O'Brien M., Johnson D., Bali V., Evans M., Franzen K., Halbish S., Helyar J., Martin A., Mudge D., Sonnenburg K., Sudak J., Roger S., Almeida S., Andrews H., Bohringer L., Bouwhuis L., Brady L., Carpenter A., Warren S., Elias T., Bannister K., Chew G., Clarke J., Faull R., Hooper A., Jeffs L., Napier A., Peh C., Pirone K., Skilton F., Ranganathan D., Best J., Hart L., Healy H., Morgan C., Ratanjee S., Salisbury A., Jose M., Freeman J., Hamilton R., Kirkland G., Read G., Anderson H., Boekel K., Farrell M., Foreman A., Iliev K., Pedagogos E., Raspudic T., Pollock C., Cooper B., Kesselhut J., Macadam C., Pearse J., Rowland C., Tully H., Irish A., Dogra G., Coutts P., Hayes L., Khoo D., Nathoo B., Shakespeare K., Warger A., Gillin A., Burman J., George C., Sherwood S., Snelling P., Stevens C., Hutchison B., Luxton G., Devenny N., Herson H., Pellicano S., Kelly J., Coutelas J., Garlinge C., McClelland A., Pirabhahar S., Saleh H., Langham R., Englebright B., Giang M., Lanteri M., Mullins K., Turner C., Collett P., Stokoe S., Sutherland K., Talafua D., Talaulikar G., Clarkson A., Rees C., Carney G., Falk M., Gracey D., Jadeer A., Johnson P., Karpe K., Singer R., Walters G., McDonald S., Burgess J., Fischer K., Gentgall M., Hockley M., Veitch D., De Jersey P., Gillam A., Hartig V., Holland K., McArdle J., Washington W., Rangan G., Mikaheal M., Murie P., Perez N., Punnoose N., Smolonogov T., Taler N., Williams G., Wen C., Kohlhagen J., Wessels J., Johnson S., Reid A., Ryan J., Taprell D., Auinger M., Eigner M., Kodras K., Leithner C., Magpantay L., Marterer C., Prager R., Prinz C., Seiringer E., Kramar R., Mitter E., Stummvoll H., Dieplinger G., Wenzel R., Stolz G., Drose S., Edlinger E., Headlam-Leitner E., Miska H., Then M., Weninger S., Lhotta K., Neyer U., Dickie H., Smodek S., Sprenger-Mahr H., Rosenkranz A., Zitt E., Mayr B., Schinner A., Soltys G., Begin V., Brunet S., Cournoyer S., Gelinas M., Giroux C., Martineau J., Roy M., Savoie L., Agharazii M., Blouin J., Desmeules S., Langlois S., Samson F., Wong G., Constantini L., Jing J., Malko J., Rivers C., Rochester D., Skilling C., Wadgymar A., Wu G., Kates D., Husch J., Mantle M., Turri L., Barrett B., Curtis B., Greeley B., Hannaford M., Harnett J., Kelly M., Langille E., Morgan J., Murphy S., Karim M., Arbo T., Carpenito G., Chan V., DaRoza G., Friesen M., Kraus D., Lam S., Lange B., Minhas S., Starko R., Torng S., Vela K., Madore F., Roy P., Troyanov S., Bonnardeaux A., Lauzon L., Pichette V., Yeates K., Mahoney K., Myers C., Pilkey R., Moist L., Edgar M., House A., Kortas C., Mindorff S., Tam P., Chow S., Fung J., Nagai G., Ng P., Sikaneta T., Ting R., Forzley B., Clouatre Y., Cooper S., DaCosta H., Granger S., Valley S., Karunakaran S., Abdulhadi M., Altwasser C., Anderson S., Bergquist L., Wijeyesinghe C., Berst L., Horgan K., Coles K., Lotter T., Robson L., Barre P., Golden J., Golden M., Tanguay N., Rigatto C., Armstrong S., Fine A., Fontaine B., Friesen D., Henry S., Kraushar M., Reslerova M., Verrelli M., Rabbat C., Clase C., Suva G., Winegard N., Goldstein M., Curvelo S., Donnelly S., Huckle J., Marticorena R., Chan-Yan C., Chiu A., DeLuca L., Flamer D., Gill J., Jamal A., Jung B., Kiaii M., Landsberg D., Rozen N., Taylor P., Werb R., Pylypchuk G., Ahmed A., Barton J., Hundseth M., Kappel J., Keindel I., Klassen J., Pylypchuk S., Rindall M., Tobe S., Naimark D., Agelopoulos M., Chessman M., Hladunewich M., Perkins N., Sainsbury S., McCready W., Adams B., Tonelli M., Caldwell S., Kumar U., McMahon 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V., Aerenlund H., Braemer-Jensen M., Kamper A., Raaschou S., Heaf J., Dreyer J., Freese P., Holm M., Munch M., Gade-Rasmussen E., Bredmose K., Daugaard H., Nielsen J., Friedberg M., Jensen D., Munk Plum M., Solling K., Dieperink H., Arp Nielsen L., Friborg E., Gloe-Jakobsen A., Thye Ronn P., Rasmussen K., Andersen C., Johansen A., Odum L., Ostergaard O., Pedersen L., Lykkegaard S., Aundal M., Faureholm Huess S., Danielsen H., Madsen J., Nyvang M., Ekstrand A., Boman H., Hartman J., Lipponen A., Lithovius R., Rauta V., Salmela A., Saloranta K., Forslund T., Koskiaho P., Jaaskelainen K., Kanninen M., Laine K., Asola M., Huhti J., Pentti M., Metsarinne K., Heiro M., Koivuviita N., Saarinen M., Tertti R., Choukroun G., Fournier A., Ducloux D., Marechal F., Simula Faivre D., Combe C., Douillet M., Lamblot T., Nardi H., Vendrely B., Bourbigot B., Ferlandin S., Zaoui P., Jouet C., Geffroy-Guiberteau S., Bugnazet L., Aldigier J., El Hamel-Belili C., Giraud S., Dussol B., Berland Y., Chollet 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A., Schulz E., Krumwiede A., Kruse D., Lucke S., Keim H., Fink H., Fischer S., Klingbeil A., Kuhlmei K., Ortwein-Horn N., Merker L., Bayer B., Benamar K., Emmert S., Floten E., Holzheuer K., Lummer M., Ossendorf E., Scholz M., Oppitz M., Georgiew L., Tripps C., Wendehake M., Lange D., Pingel V., Brause M., Schanze W., Duygulu E., Dellanna F., Heinemann-Nieberding S., Sturmer C., Wieczorek K., Zarga O., Kullmer B., Kullmer S., Akin M., Gondolf M., Schutterle S., Walker G., Bertsch R., Seul M., Allendorff J., Siehler R., Stemmler S., Baldus M., Adler A., Harter S., Wurmell W., Moller M., Hame C., Muller M., Schreiber M., Schurfeld C., Millington-Herrmann M., Benschneider A., Gaffal J., Sprunken U., Bohling M., Wunderlich S., Schramm L., Kollenbrath C., Netzer K., Sieber T., Zimmermann J., Bellersen M., Uerkvitz M., David-Walek T., Hauschildt B., Leimenstoll G., Lonnemann G., Hilfenhaus M., Benedetto C., Stockmann S., Ichtiaris P., Jungmann A., Neumeier K., Stoof A., Bohmer K., Kirpal A., 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Weyer J., Heine C., Kirste P., Zemann B., Alscher D., Rumpf D., Wullen B., Bengel A., Friedrich B., Kirschner T., Knodler U., Machleidt C., Niederstrasser K., Noack E., Wilhelm J., Heuer H., Dulea J., Piolot R., Rudke M., Treinen G., Elberg B., Hanke J., Nitschke T., Rosendahl C., Schmitz A., Schrader J., Kulschewski A., Lubcke C., Hammersen F., Luders S., Venneklaas U., Muhlfeld A., Arabi Al-Khanne F., Ketteler M., Politt D., Schuster C., Eitner F., Goretz U., Heidenreich S., Janssen U., Kranz A., Moormann E., Schneider B., Weber W., Frei U., Jovanovic T., Asmus H., Canaan-Kuhl S., Pannier L., Petersen S., Pluer M., Schaeffner E., Schafer C., Warncke S., Schmieder R., Donhauser C., Schulze B., Koziolek M., Bechtel W., Kurz B., Strutz F., Bramlage C., Dreyer S., Mommeyer E., Niemann J., Scheel A., Troche-Polzien I., Weber F., Heine G., Girndt M., Lizzi F., Rogacev K., Lindner T., Achenbach H., Peschel K., Beige J., Jentho S., Kreyssig C., Prill K., Renders L., Walcher J., Cerny S., 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B.B., Krishnan S., Seet W.W.T., Liew S.K., Keng T.C., Tobe T., Deelen M., Klaassen I., Grave W., Emmen M., Janssen W., Bossen W., Elzinga B., Van Der Velden A., Hemmelder M., Slagman M., Waanders F., Viergever P., Boerema I., Potter Van Loon B., Muthert B., Geers T., Schollaert N., Van Weverwijk I., Veen P., Woittiez A., Krikken J., Kwakernaak A., Visser F., Navis G., Hoekstra F., Hawkins S., McGregor D., Usher J., MacGinley R., Schollum J., Ellis G., Voss D., Rosman J., Upjohn M., Panlilio N., Madhan K., Naicker V., Anderson E., Bushell M., Lumb N., Pepperell B., Sizeland P., Hayett S., Sullivan N., Tuffery C., Macdonald A., Ostapowicz T., Wessel-Aas T., Wessel-Aas H., Bjorbaek E., Bjorbaek R., Simso I., Oien C., Bergrem H., Espedal S., Kronborg J., Solbakken K., Rocke J., Aakervik O., Haugen V., Eide T., Berglund J., Loland W., Schei T., Stromsaether C., Willadsen H., Lyngdal P., Vad A., Waldum B., Froslid G., Roaldsnes C., Rustad D., Soderblom P., Eriksen B., Hanssen E., Julsrud J., Mathisen U., Pedersen M., Rumsfeld M., Toft I., Berget K., Landsverk K., Tveiten G., Wamstad H., Klinger M., Krajewska M., Golebiowski T., Kusztal M., Spiechowicz-Zaton U., Rutkowski B., Renke M., Tylicki L., Czekalski S., Koziol L., Wanic-Kossowska M., Wasik-Olejnik A., Nowicki M., Dryja P., Kurnatowska I., Zawiasa A., Ciszek M., Gomolka M., Mysliwiec M., Brzosko S., Mazerska M., Hruby Z., Koscielniak K., Stanek-Piotrowska M., Mesjasz J., Rudka R., Baranski M., Jupowiecki J., Klein D., Switalski M., Kuriga M., Ostrowski M., Lidman A., Linde T., Waltersson K., Weiss L., Andersson G., Lindell C., Welander G., Jacobson S., Edensjo P., Wallin J., Linder M., Karsberg M., Hellgren K., Lonn I., Frisenette-Fich C., Johansson A., Lundstrom A., Mauritz N., Stahl-Nilsson A., Tobafard N., Hellberg O., Ejemar E., Von Schmalensee N., Gunne T., Eriksson A., Ostberg S., Svensson C., Mulec H., Jacobsson A., Karlsson M., Onnermalm L., Osagie S., Ekengren U., Larsson M., Lindberger K., Olofsson A., Samuelsson O., Beagan L., Dezfoolian H., Just M., Ortegren L., Saeed A., Strand U., Ramsauer B., Hultstrom D., Nordlinder K., Sundberg I., Oqvist B., Green C., Fernstrom A., Cassel A., Goransson I., Gylling M., Jorgensen A., Sterner G., Christensson A., Hjelmstedt P., Nystrom A., Sundin P., Samuelsson I., Tidman M., Johansson M., Lofgren Andersson M., Ohman M., Andersson P., Hallberg Karlsson A., Ringstad L., Chittinandana A., Chailimpamontree W., Gojaseni P., Singprasert R., Tungsanga K., Amphun W., Intim P., Kanjanabuch T., Poowarattanakul D., Treratha C., Wongvan P., Jittikanont S., Suriya T., Indrasthitya P., Sumethkul V., Ingsathit A., Jansomwong J., Lertchalorarn K., Phachiyanukul V., Phiromkit T., Saengsri S., Vareesangthip K., Chawanasuntorapoj R., Kiattisunthorn K., Larpkitkachorn R., Webster J., Henderson J., Jayne D., Hollis J., Townsend K., Harron C., Bleakley N., Hanley N., Morgan S., Brittney L., Brown H., Maxwell P., Murtagh H., Thomas M., Burke E., Carmody M., Cox G., Dasgin J., Ali G., Whitehouse L., Williams V., Brown E., Dlelana G., Esson A., Fagerbrink S., Marshall F., Mazibuko B., Nelson C., Russell E., Williams R., Altmann P., McNichols-Thomas C., Parsons K., MacGregor M., McGowan J., Mead P., Gilbanks K., Sanderson M., Fluck R., Chandler G., Hulme L., Smith J., Tse Y., West C., Taylor J., Breakspear S., Burgess B., Isles C., Bell J., Duignan J., Gorman J., Swainson C., Beveridge C., Cairns A., Miller D., Paterson F., Smith L., Kumwenda M., Glover R., Geddes C., Gemmell C., Grieve I., Matthews E., McLaren B., Meyer B., Spiers A., Banks R., Apperley P., Patterson T., Paynter H., Scoble J., Thom D., Watkins J., Kalra P., Gowland S., Haydock L., Smart I., Bhandari S., Gillett P., James K., Lewis R., Melville H., Tamimi A., Williams P., Heath T., Small S., Paterson A., Gibson N., Laven C., Wilson T., Cairns H., Casley-Ready K., Warwick G., Fentum B., James J., Kumar T., Marshall R., Ratcliffe F., Shenton A., Warwicker P., Bowser M., Mumford C., Mitra S., Woolfson R., Yang R., Williams A., Richards K., Turner A., Odum J., Rylance P., Smallwood A., Ward J., Henderson I., McMahon M., Ross C., Burrows M., Morais J., Rajan S., Tindall H., Barrett C., Kelly F., El-Nahas M., Bartholomew J., Edwards L., Okhuoya F., Bebb C., Cassidy M., Brand S., Quashie-Howard M., Taggart C., Capps N., Tonks L., Mason J., Powell S., Watkins L., Ball S., Dutton M., Fifer L., McGlynn F., Wood M., Jenkins D., Allan N., Fahal I., Elhag-Ali H., King J., Peel R., Potts L., Logie I., McGhie F., Naik R., Parry R., Andain K., Durkin S., D'Souza R., Harrison D., Cooke J., Kinyanjui R., Harper J., Algate K., McCarthy M., Van Eker D., Thuraisingham R., Chinodya M., Deelchand V., Garcia R., Ngango R., Rolfe C., Williams K., Solomon L., Heap T., MacDowall P., Saunderson Smith L., MacDiarmaid-Gordon A., Harman W., Smithson H., Robertson D., Gammon B., O'Grady D., Verow C., Rogerson M., Berry L., Gough C., Hayward E., Jones C., Payne T., Rowe L., Sibley C., 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M., Kodras K., Leithner C., Magpantay L., Marterer C., Prager R., Prinz C., Seiringer E., Kramar R., Mitter E., Stummvoll H., Dieplinger G., Wenzel R., Stolz G., Drose S., Edlinger E., Headlam-Leitner E., Miska H., Then M., Weninger S., Lhotta K., Neyer U., Dickie H., Smodek S., Sprenger-Mahr H., Rosenkranz A., Zitt E., Mayr B., Schinner A., Soltys G., Begin V., Brunet S., Cournoyer S., Gelinas M., Giroux C., Martineau J., Roy M., Savoie L., Agharazii M., Blouin J., Desmeules S., Langlois S., Samson F., Wong G., Constantini L., Jing J., Malko J., Rivers C., Rochester D., Skilling C., Wadgymar A., Wu G., Kates D., Husch J., Mantle M., Turri L., Barrett B., Curtis B., Greeley B., Hannaford M., Harnett J., Kelly M., Langille E., Morgan J., Murphy S., Karim M., Arbo T., Carpenito G., Chan V., DaRoza G., Friesen M., Kraus D., Lam S., Lange B., Minhas S., Starko R., Torng S., Vela K., Madore F., Roy P., Troyanov S., Bonnardeaux A., Lauzon L., Pichette V., Yeates K., Mahoney K., Myers C., Pilkey R., Moist L., Edgar M., House A., Kortas C., Mindorff S., Tam P., Chow S., Fung J., Nagai G., Ng P., Sikaneta T., Ting R., Forzley B., Clouatre Y., Cooper S., DaCosta H., Granger S., Valley S., Karunakaran S., Abdulhadi M., Altwasser C., Anderson S., Bergquist L., Wijeyesinghe C., Berst L., Horgan K., Coles K., Lotter T., Robson L., Barre P., Golden J., Golden M., Tanguay N., Rigatto C., Armstrong S., Fine A., Fontaine B., Friesen D., Henry S., Kraushar M., Reslerova M., Verrelli M., Rabbat C., Clase C., Suva G., Winegard N., Goldstein M., Curvelo S., Donnelly S., Huckle J., Marticorena R., Chan-Yan C., Chiu A., DeLuca L., Flamer D., Gill J., Jamal A., Jung B., Kiaii M., Landsberg D., Rozen N., Taylor P., Werb R., Pylypchuk G., Ahmed A., Barton J., Hundseth M., Kappel J., Keindel I., Klassen J., Pylypchuk S., Rindall M., Tobe S., Naimark D., Agelopoulos M., Chessman M., Hladunewich M., Perkins N., Sainsbury S., McCready W., Adams B., Tonelli M., Caldwell S., Kumar U., McMahon 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Knogl A., Flege F., Franke K., Groth P., Parensen E., Bockmann M., Przyklenk P., Piazolo L., Thinius-Jaudas L., Versen A., Hettich R., Arendt R., Geiger K., Hoppe H., Schwarting A., Beyer T., Faust J., Hazenbiller A., Tschirner S., Grupp C., Dorsch O., Eigner-Schmidtchen M., Michler K., Roth J., Schramm S., Waldmuller G., Riedl B., Vogele-Dirks H., Linz J., Biggar P., Hennemann H., Bauer G., Buchholz J., Fischer P., Bihlmaier W., Baumann A., Peichl B., Roser S., Ludewig S., Ricksgers M., Szendzielorz M., Baus A., Baust K., Schaller P., Schnellbacher G., Sorensen S., Buschges-Seraphin B., Hauenstein L., Hofmann B., Nikolay J., Merkel F., Nebel M., Petersen J., Schweb S., Zeissler H., Baumhackel K., Krauss A., Schafer R., Pastor A., Zielinski B., Strauss H., Theis H., Burkhardt K., Heckel M., Hussendorfer K., Bahner U., Brandl M., Hammerl-Kraus B., Herrmann D., Kramer H., Baudenbacher H., Blaser C., Buschmann G., Eckert G., Ehrich H., Hofmann K., Huller U., Geiger H., Becker B., Hoischen 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Dasgin J., Ali G., Whitehouse L., Williams V., Brown E., Dlelana G., Esson A., Fagerbrink S., Marshall F., Mazibuko B., Nelson C., Russell E., Williams R., Altmann P., McNichols-Thomas C., Parsons K., MacGregor M., McGowan J., Mead P., Gilbanks K., Sanderson M., Fluck R., Chandler G., Hulme L., Smith J., Tse Y., West C., Taylor J., Breakspear S., Burgess B., Isles C., Bell J., Duignan J., Gorman J., Swainson C., Beveridge C., Cairns A., Miller D., Paterson F., Smith L., Kumwenda M., Glover R., Geddes C., Gemmell C., Grieve I., Matthews E., McLaren B., Meyer B., Spiers A., Banks R., Apperley P., Patterson T., Paynter H., Scoble J., Thom D., Watkins J., Kalra P., Gowland S., Haydock L., Smart I., Bhandari S., Gillett P., James K., Lewis R., Melville H., Tamimi A., Williams P., Heath T., Small S., Paterson A., Gibson N., Laven C., Wilson T., Cairns H., Casley-Ready K., Warwick G., Fentum B., James J., Kumar T., Marshall R., Ratcliffe F., Shenton A., Warwicker P., Bowser M., Mumford C., Mitra S., Woolfson R., Yang R., Williams A., Richards K., Turner A., Odum J., Rylance P., Smallwood A., Ward J., Henderson I., McMahon M., Ross C., Burrows M., Morais J., Rajan S., Tindall H., Barrett C., Kelly F., El-Nahas M., Bartholomew J., Edwards L., Okhuoya F., Bebb C., Cassidy M., Brand S., Quashie-Howard M., Taggart C., Capps N., Tonks L., Mason J., Powell S., Watkins L., Ball S., Dutton M., Fifer L., McGlynn F., Wood M., Jenkins D., Allan N., Fahal I., Elhag-Ali H., King J., Peel R., Potts L., Logie I., McGhie F., Naik R., Parry R., Andain K., Durkin S., D'Souza R., Harrison D., Cooke J., Kinyanjui R., Harper J., Algate K., McCarthy M., Van Eker D., Thuraisingham R., Chinodya M., Deelchand V., Garcia R., Ngango R., Rolfe C., Williams K., Solomon L., Heap T., MacDowall P., Saunderson Smith L., MacDiarmaid-Gordon A., Harman W., Smithson H., Robertson D., Gammon B., O'Grady D., Verow C., Rogerson M., Berry L., Gough C., Hayward E., Jones C., Payne T., Rowe L., Sibley C., Szymanski J., Almond M., Bourton L., Bromwich C., Dawson S., Mason S., Oliveira D., Ramkhelawon R., Tuazon J., Andrews P., Archer K., Moore A., Thomas G., Velazquez C., Mumtaz R., Roberts R., Farquhar F., Ott J., Fenwick S., Callaway A., Garrett P., Dees L., McDonagh U., Garner S., Zehnder D., Aldridge N., Dyer C., Gomez M., Hewins S., McCarthy K., Rush J., Spencer S., Harvey M., Mills H., Drew P., Henry M., Wilberforce S., Worth D., Adair Z., Hartley J., Jibani M., Jones D., Swan S., Shamp T., Alcorn H., Bookey J., Cannon C., Jarvis K., Muesing C., Murphy M., Muster H., Planting M., Strand C., Middleton J., Gitter K., Mace N., Schumm D., Pogue V., Alimohammadi B., Arora P., Herbert L., Cheng J., Dowie D., Mohan S., Peters G., Tuttle K., Albritton S., Benedetti R., Joshi S., Lund B., Shuler L., Trevino M., Mai K., Osborn T., Parekh R., Eustace J., Novak G., Patterson S., Lindsey C., Hill T., Liston M., Wiegmann T., Nagaria A., Hurd C., Hurst A., Omoscharka E., Parks S., and Price V.
- Abstract
Background: Lowering low-density lipoprotein (LDL) cholesterol with statin therapy has been shown to reduce the incidence of atherosclerotic events in many types of patient, but it remains uncertain whether it is of net benefit among people with chronic kidney disease (CKD). Method(s): Patients with advanced CKD (blood creatinine >=1.7 mg/dL [>= 150 mumol/L] in men or >=1.5 mg/dL [ >= 130 mumol/L] in women) with no known history of myocardial infarction or coronary revascularization were randomized in a ratio of 4:4:1 to ezetimibe 10 mg plus simvastatin 20 mg daily versus matching placebo versus simvastatin 20 mg daily (with the latter arm rerandomized at 1 year to ezetimibe 10 mg plus simvastatin 20 mg daily vs placebo). The key outcome will be major atherosclerotic events, defined as the combination of myocardial infarction, coronary death, ischemic stroke, or any revascularization procedure. Results A total of 9,438 CKD patients were randomized, of whom 3,056 were on dialysis. Mean age was 61 years, two thirds were male, one fifth had diabetes mellitus, and one sixth had vascular disease. Compared with either placebo or simvastatin alone, allocation to ezetimibe plus simvastatin was not associated with any excess of myopathy, hepatic toxicity, or biliary complications during the first year of follow-up. Compared with placebo, allocation to ezetimibe 10 mg plus simvastatin 20 mg daily yielded average LDL cholesterol differences of 43 mg/dL (1.10 mmol/L) at 1 year and 33 mg/dL (0.85 mmol/L) at 2.5 years. Follow-up is scheduled to continue until August 2010, when all patients will have been followed for at least 4 years. Conclusions SHARP should provide evidence about the efficacy and safety of lowering LDL cholesterol with the combination of ezetimibe and simvastatin among a wide range of patients with CKD.Copyright © 2010, Mosby, Inc. All rights reserved.
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- 2010
27. Measures of response in clinical trials of systemic sclerosis: the combined response index for systemic sclerosis (CRISS) and Outcome Measures in Pulmonary Arterial Hypertension related to Systemic Sclerosis (EPOSS)
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Khanna, D, Distler, O, Avouac, J, Behrens, F, Clements, P J, Denton, C, Foeldvari, I, Giannini, E, Huscher, D, Kowal-Bielecka, O, Lovell, D, Matucci-Cerinic, M, Mayes, M, Merkel, P A, Nash, P, Opitz, C F, Pittrow, D, Rubin, L, Seibold, J R, Steen, V, Strand, C V, Tugwell, P S, Varga, J, Zink, A, Furst, D E, Khanna, D, Distler, O, Avouac, J, Behrens, F, Clements, P J, Denton, C, Foeldvari, I, Giannini, E, Huscher, D, Kowal-Bielecka, O, Lovell, D, Matucci-Cerinic, M, Mayes, M, Merkel, P A, Nash, P, Opitz, C F, Pittrow, D, Rubin, L, Seibold, J R, Steen, V, Strand, C V, Tugwell, P S, Varga, J, Zink, A, and Furst, D E
- Abstract
There have been steady efforts to develop a combined response index for systemic sclerosis (CRISS). A parallel and equally successful effort has been made by an Expert Panel on Outcome Measures in PAH related to Systemic Sclerosis (EPOSS) to measure effect in treatment of pulmonary arterial hypertension of systemic sclerosis (PAH-SSc). CRISS conducted a Delphi process combined with expert review to identify 11 candidate domains for inclusion in a core set of outcomes for SSc clinical trials: soluble biomarkers, cardiac, digital ulcers, gastrointestinal, global health, health related quality of life (HRQOL) and function, musculoskeletal, pulmonary, Raynaud's, renal, and skin. Tools within domains were also agreed upon. Concentrating on one aspect of disease, PAH, EPOSS also conducted a Delphi process and judged the following domains as the most appropriate for randomized controlled trials in PAH-SSc: lung vascular/pulmonary arterial pressure, cardiac function, exercise testing; severity of dyspnea, discontinuation of treatment; quality of life/activities of daily living; global state; and survival. Possible useful tools within each domain were also agreed on. Patient derived, physician derived, and objective measures of response will be included and combined with the idea that each reflects different aspects of PAH (EPOSS) and overall disease (CRISS) although this assumption may not prove true and can be separated if statistically and clinically valid to do so. In either case, prospective studies will require measurement of all domains, and tools are required and will be developed to define appropriate combined measures of response. CRISS and EPOSS are being developed through the OMERACT process. Through Delphi process and literature review significant progress has been made for both indices, and prospective data are being collected.
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- 2009
28. Challenging South Australia mega-survey utilizes recent acquisition technologies to complete 3D survey in a single weather window
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Manning, T., primary, Green, E., additional, Nicol, G., additional, Strand, C., additional, van der Wal, A., additional, and Mostavan, A., additional
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- 2013
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29. Using Modelled Far-field Signatures of Airgun Arrays to Estimate Impact on Marine Mammals
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Goertz, A., primary, Ali, J., additional, Wislřff, J.F., additional, and Strand, C., additional
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- 2013
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30. Impact of Survey Design and Acquisition Technology on 3D Marine Mega-Survey Success
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Manning, T.A., primary, Nicol, G., additional, Green, E., additional, Strand, C., additional, van der Wal, A., additional, and Mostavan, A., additional
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- 2013
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31. Abstract P2-10-28: The Prognostic Index, KiGE, Combining Proliferation, Histological Grade and Estrogen Receptor Status Challenges Gene Profiling – A Study in 1,854 Chemo-Naïve Women with N0/N1 Primary Breast Cancer.
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Strand, C, primary, Bak, M, additional, Borgquist, S, additional, Chebil, G, additional, Falck, A-K, additional, Fjällskog, M-L, additional, Grabau, D, additional, Hedenfalk, I, additional, Jirström, K, additional, Klintman, M, additional, Malmtröm, P, additional, Olsson, H, additional, Rydén, L, additional, Stål, O, additional, Bendahl, P-O, additional, and Fernö, M, additional
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- 2012
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32. Abstract P2-10-19: Are the mitotic factors Mitotic Activity Index (MAI) and Phosphohistone 3 (PPH3) stronger prognostic proliferation factors than Ki67 in node-negative breast cancer?
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Klintman, M, primary, Strand, C, additional, Gudlaugsson, E, additional, Janssen, E, additional, Skaland, I, additional, Malmström, P, additional, Baak, J, additional, and Fernö, M, additional
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- 2012
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33. High resolution MR anatomy of the subthalamic nucleus: Imaging at 9.4T with histological validation
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Massey, L.A., primary, Miranda, M.A., additional, Zrinzo, L., additional, Al-Helli, O., additional, Parkes, H.G., additional, Thornton, J.S., additional, So, P.-W., additional, White, M.J., additional, Mancini, L., additional, Strand, C., additional, Holton, J.L., additional, Hariz, M.I., additional, Lees, A.J., additional, Revesz, T., additional, and Yousry, T.A., additional
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- 2012
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34. Designing 3D Marine Seismic Surveys for Efficiency
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Strand, C., primary and Mostavan, A., additional
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- 2011
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35. Utilization of dried blood spots within drug discovery: modification of a standard DiLab® AccuSampler® to facilitate automatic dried blood spot sampling
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Clark, G T, primary, Giddens, G, additional, Burrows, L, additional, and Strand, C, additional
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- 2011
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36. Composite Measures in Psoriatic Arthritis: A Report from the GRAPPA 2009 Annual Meeting
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HELLIWELL, PHILIP S., primary, FITZGERALD, OLIVER, additional, STRAND, C. VIBEKE, additional, and MEASE, PHILIP J., additional
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- 2011
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37. Essential hypernatremia
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GOSSAIN, VED V., KINZEL, TERRY, STRAND, C VIBEKE, and ROVNER, DAVID R.
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- 1978
38. Abstract P3-10-06: Modeling Prognostic Markers in Breast Cancer — Are We Using Them the Optimal Way?
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Strand, C, primary, Falck, A-K, additional, Jirström, K, additional, Malmström, P, additional, Rydén, L, additional, Bendahl, P-O, additional, and Fernö, M., additional
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- 2010
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39. 127 Cyclin A – an alternative to gene expression profiling for subdividing histological grade 2 breast cancer into groups with different prognosis
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Strand, C., primary, Ahlin, C., additional, Fjällskog, M.L., additional, Malmström, P., additional, and Fernö, M., additional
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- 2010
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40. Reducing Infill – Real Time Application of Geophysically Based Coverage Specifications
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Strand, C., primary, Campbell, S., additional, and E. Dhelie, P., additional
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- 2010
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41. Content and Criterion Validity of the Preliminary Core Dataset for Clinical Trials in Fibromyalgia Syndrome
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CHOY, ERNEST H., primary, ARNOLD, LESLEY M., additional, CLAUW, DANIEL J., additional, CROFFORD, LESLIE J., additional, GLASS, JENNIFER M., additional, SIMON, LEE S., additional, MARTIN, SUSAN A., additional, STRAND, C. VIBEKE, additional, WILLIAMS, DAVID A., additional, and MEASE, PHILIP J., additional
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- 2009
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42. Measures of Response in Clinical Trials of Systemic Sclerosis: The Combined Response Index for Systemic Sclerosis (CRISS) and Outcome Measures in Pulmonary Arterial Hypertension Related to Systemic Sclerosis (EPOSS)
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KHANNA, DINESH, primary, DISTLER, OLIVER, additional, AVOUAC, JEROME, additional, BEHRENS, FRANK, additional, CLEMENTS, PHILIP J., additional, DENTON, CHRISTOPHER, additional, FOELDVARI, IVAN, additional, GIANNINI, EDWARD, additional, HUSCHER, DOERTE, additional, KOWAL-BIELECKA, OTYLIA, additional, LOVELL, DANIEL, additional, MATUCCI-CERINIC, MARCO, additional, MAYES, MAUREEN, additional, MERKEL, PETER A., additional, NASH, PETER, additional, OPITZ, CHRISTIAN F., additional, PITTROW, DAVID, additional, RUBIN, LEWIS, additional, SEIBOLD, JAMES R., additional, STEEN, VIRGINIA, additional, STRAND, C. VIBEKE, additional, TUGWELL, PETER S., additional, VARGA, JOHN, additional, ZINK, ANGELA, additional, and FURST, DANIEL E., additional
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- 2009
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43. Fibromyalgia Syndrome Module at OMERACT 9: Domain Construct
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MEASE, PHILIP, primary, ARNOLD, LESLEY M., additional, CHOY, ERNEST H., additional, CLAUW, DANIEL J., additional, CROFFORD, LESLIE J., additional, GLASS, JENNIFER M., additional, MARTIN, SUSAN A., additional, MOREA, JESSICA, additional, SIMON, LEE, additional, STRAND, C. VIBEKE, additional, and WILLIAMS, DAVID A., additional
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- 2009
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44. Observations from the OMERACT Drug Safety Summit, May 2008
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SIMON, LEE S., primary, STRAND, C. VIBEKE, additional, BOERS, MAARTEN, additional, BROOKS, PETER M., additional, HENRY, DAVID, additional, and TUGWELL, PETER S., additional
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- 2009
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45. How to Ascertain Drug Safety in the Context of Benefit. Controversies and Concerns: Table 1.
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SIMON, LEE S., primary, STRAND, C. VIBEKE, additional, BOERS, MAARTEN, additional, BROOKS, PETER M., additional, TUGWELL, PETER S., additional, BOMBARDIER, CLAIRE, additional, FRIES, JAMES F., additional, HENRY, DAVID, additional, GOLDKIND, LARRY, additional, GUYATT, GORDON, additional, LAUPACIS, ANDREAS, additional, LYND, LARRY, additional, MacDONALD, TOM, additional, MAMDANI, MUHAMMAD, additional, MOORE, ANDREW, additional, SAAG, KEN S., additional, SILMAN, ALAN J., additional, STEVENS, RANDALL, additional, and TYNDALL, ALAN, additional
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- 2009
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46. Variation in Outcome Measures in Hip and Knee Arthroplasty Clinical Trials: A Proposed Approach to Achieving Consensus
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RIDDLE, DANIEL L., primary, STRATFORD, PAUL W., additional, SINGH, JASVINDER A., additional, and STRAND, C. VIBEKE, additional
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- 2009
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47. Measuring Worker Productivity: Frameworks and Measures
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BEATON, DORCAS, primary, BOMBARDIER, CLAIRE, additional, ESCORPIZO, REUBEN, additional, ZHANG, WEI, additional, LACAILLE, DIANE, additional, BOONEN, ANNELIES, additional, OSBORNE, RICHARD H., additional, ANIS, ASLAM H., additional, STRAND, C. VIBEKE, additional, and TUGWELL, PETER S., additional
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- 2009
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48. Developing a Standardized Definition for Disease “Flare” in Rheumatoid Arthritis (OMERACT 9 Special Interest Group): Table 1.
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BINGHAM, CLIFTON O., primary, POHL, CHRISTOPH, additional, WOODWORTH, THASIA G., additional, HEWLETT, SARAH E., additional, MAY, JAMES E., additional, RAHMAN, MAHBOOB U., additional, WITTER, JAMES P., additional, FURST, DANIEL E., additional, STRAND, C. VIBEKE, additional, BOERS, MAARTEN, additional, and ALTEN, RIEKE E., additional
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- 2009
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49. Multiple Computer-based Methods of Measuring Joint Space Width Can Discriminate Between Treatment Arms in the COBRA Trial — Update of an Ongoing OMERACT Project
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SHARP, JOHN T., primary, ANGWIN, JANE, additional, BOERS, MAARTEN, additional, DURYEA, JEFF, additional, FINCKH, AXEL, additional, HALL, JAMES R., additional, KAUFFMAN, JOOST A., additional, LANDEWÉ, ROBERT, additional, LANGS, GEORG, additional, LUKAS, CÉDRIC, additional, MOENS, H.J. BERNELOT, additional, PELOSCHEK, PHILIPP, additional, STRAND, C. VIBEKE, additional, and van der HEIJDE, DÉSIRÉE, additional
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- 2009
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50. Neuropathology of primary adult-onset dystonia
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Holton, J. L., primary, Schneider, S. A., additional, Ganesharajah, T., additional, Gandhi, S., additional, Strand, C., additional, Shashidharan, P., additional, Barreto, J., additional, Wood, N. W., additional, Lees, A. J., additional, Bhatia, K. P., additional, and Revesz, T., additional
- Published
- 2008
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