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1. Symptom monitoring with electronic patient-reported outcomes during cancer treatment: final results of the PRO-TECT cluster-randomized trial

Author

Basch, Ethan, Schrag, Deborah, Jansen, Jennifer, Henson, Sydney, Ginos, Brenda, Stover, Angela M., Carr, Philip, Spears, Patricia A., Jonsson, Mattias, Deal, Allison M., Bennett, Antonia V., Thanarajasingam, Gita, Rogak, Lauren, Reeve, Bryce B., Snyder, Claire, Bruner, Deborah, Cella, David, Kottschade, Lisa A., Perlmutter, Jane, Geoghegan, Cindy, Given, Barbara, Mazza, Gina L., Miller, Robert, Strasser, Jon F., Zylla, Dylan M., Weiss, Anna, Blinder, Victoria S., Wolf, Anna P., and Dueck, Amylou C.

Published
2025
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2. Smoking and Radiation-induced Skin Injury: Analysis of a Multiracial, Multiethnic Prospective Clinical Trial.

Author

Hu, Jennifer, Weaver, Kathryn, Lively, Mark, Winkfield, Karen, Shaw, Edward, Diaz, Luis, Brown, Doris, Strasser, Jon, Sears, Judith, Lesser, Glenn, Hughes, Ryan, Ip, Edward, and Urbanic, James

Subjects
Breast cancer, Patient reported outcomes, Radiation injuries, Radiation-induced dermatitis, Radiotherapy, Female, Humans, Breast Neoplasms, Mastectomy, Prospective Studies, Smoking, Mastectomy, Segmental, Radiation Injuries, Radiotherapy, Adjuvant
Abstract

INTRODUCTION: Smoking during breast radiotherapy (RT) may be associated with radiation-induced skin injury (RISI). We aimed to determine if a urinary biomarker of tobacco smoke exposure is associated with increased rates of RISI during and after breast RT. PATIENTS AND METHODS: Women with Stage 0-IIIA breast cancer treated with breast-conserving surgery or mastectomy followed by RT to the breast or chest wall with or without regional nodal irradiation were prospectively enrolled on a multicenter study assessing acute/late RISI. 980 patients with urinary cotinine (UCot) measurements (baseline and end-RT) were categorized into three groups. Acute and late RISI was assessed using the ONS Acute Skin Reaction scale and the LENT-SOMA Criteria. RESULTS: Late Grade 2+ and Grade 3+ RISI occurred in 18.2% and 1.9% of patients, respectively-primarily fibrosis, pain, edema, and hyperpigmentation. Grade 2+ late RISI was associated with UCot group (P= 006). Multivariable analysis identified UCot-based light smoker/secondhand smoke exposure (HR 1.79, P= .10) and smoking (HR 1.60, p = .06) as non-significantly associated with an increased risk of late RISI. Hypofractionated breast RT was associated with decreased risk of late RISI (HR 0.51, P=.03). UCot was not associated with acute RISI, multivariable analysis identified race, obesity, RT site/fractionation, and bra size to be associated with acute RISI. CONCLUSIONS: Tobacco exposure during breast RT may be associated with an increased risk of late RISI without an effect on acute toxicity. Smoking cessation should be encouraged prior to radiotherapy to minimize these and other ill effects of smoking.

Published
2022

3. Comparing the Effectiveness of Electronic Symptom Monitoring versus Usual Care in Improving Survival among Patients with Metastatic Cancer -- The PRO-TECT Trial

Author

Basch, Ethan, primary, Schrag, Deborah, additional, Henson, Sydney, additional, Jansen, Jennifer, additional, Ginos, Brenda, additional, Stover, Angela, additional, Carr, Philip, additional, Spears, Patricia, additional, Jonsson, Mattias, additional, Deal, Allison, additional, Bennett, Antonia, additional, Thanarajasingam, Gita, additional, Rogak, Lauren, additional, Reeve, Bryce, additional, Snyder, Claire, additional, Bruner, Deborah, additional, Cella, David, additional, Kottschade, Lisa, additional, Perlmutter, Jane, additional, Geoghegan, Cindy, additional, Samuel-Ryals, Cleo, additional, Given, Barbara, additional, Mazza, Gina, additional, Miller, Robert, additional, Strasser, Jon, additional, Zylla, Dylan, additional, Rapperport, Anna, additional, Weiss, Anna, additional, Blinder, Victoria, additional, and Dueck, Amylou, additional

Published
2024
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5. Association Between Inflammatory Biomarker C-Reactive Protein and Radiotherapy-Induced Early Adverse Skin Reactions in a Multiracial/Ethnic Breast Cancer Population.

Author

Hu, Jennifer, Urbanic, James, Case, L, Takita, Cristiane, Wright, Jean, Brown, Doris, Langefeld, Carl, Lively, Mark, Mitchell, Sandra, Thakrar, Anu, Bryant, David, Baglan, Kathy, Strasser, Jon, Baez-Diaz, Luis, Lesser, Glenn, and Shaw, Edward

Subjects
Adult, Aged, Aged, 80 and over, Biomarkers, Breast Neoplasms, C-Reactive Protein, Ethnicity, Female, Humans, Inflammation, Middle Aged, Radiodermatitis, Radiotherapy, Skin, Young Adult
Abstract

Purpose This study examined an inflammatory biomarker, high-sensitivity C-reactive protein (hsCRP), in radiotherapy (RT)-induced early adverse skin reactions or toxicities in breast cancer. Patients and Methods Between 2011 and 2013, 1,000 patients with breast cancer who underwent RT were evaluated prospectively for skin toxicities through the National Cancer Institute-funded Wake Forest University Community Clinical Oncology Program Research Base. Pre- and post-RT plasma hsCRP levels and Oncology Nursing Society skin toxicity criteria (0 to 6) were used to assess RT-induced skin toxicities. Multivariable logistic regression analyses were applied to ascertain the associations between hsCRP and RT-induced skin toxicities after adjusting for potential confounders. Results The study comprised 623 white, 280 African American, 64 Asian/Pacific Islander, and 33 other race patients; 24% of the patients were Hispanic, and 47% were obese. Approximately 42% and 15% of patients developed RT-induced grade 3+ and 4+ skin toxicities, respectively. The hsCRP levels differed significantly by race and body mass index but not by ethnicity. In multivariable analysis, grade 4+ skin toxicity was significantly associated with obesity (odds ratio [OR], 2.17; 95% CI, 1.41 to 3.34], post-RT hsCRP ≥ 4.11 mg/L (OR, 1.61; 95% CI, 1.07 to 2.44), and both factors combined (OR, 3.65; 95% CI, 2.18 to 6.14). Above-median post-RT hsCRP (OR, 1.93; 95% CI, 1.03 to 3.63), and change in hsCRP (OR, 2.80; 95% CI, 1.42 to 5.54) were significantly associated with grade 4+ skin toxicity in nonobese patients. Conclusion This large prospective study is the first to our knowledge of hsCRP as an inflammatory biomarker in RT-induced skin toxicities in breast cancer. We demonstrate that nonobese patients with elevated RT-related change in hsCRP levels have a significantly increased risk of grade 4+ skin toxicity. The outcomes may help to predict RT responses and guide decision making.

Published
2018

9. Abstract 1900: Radiotherapy-induced early adverse skin reactions: Comparative analysis of clinician- and patient-reported outcomes in a multi-racial/ethnic breast cancer population (WF-97609)

Author

Urbanic, James J., primary, Shaw, Edward G., additional, Takita, Cristiane, additional, Wright, Jean L., additional, Ip, Edward H., additional, Lu, Lingyi, additional, Baez-Diaz, Luis, additional, Brown, Doris R., additional, Strasser, Jon, additional, Baglan, Kathy, additional, Palmer, Mark, additional, Thakrar, Anu, additional, Curtis, Amarinthia E., additional, Lesser, Glenn, additional, and Hu, Jennifer J., additional

Published
2023
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12. Effect of Electronic Symptom Monitoring on Patient-Reported Outcomes Among Patients With Metastatic Cancer

Author

Basch, Ethan, primary, Schrag, Deborah, additional, Henson, Sydney, additional, Jansen, Jennifer, additional, Ginos, Brenda, additional, Stover, Angela M., additional, Carr, Philip, additional, Spears, Patricia A., additional, Jonsson, Mattias, additional, Deal, Allison M., additional, Bennett, Antonia V., additional, Thanarajasingam, Gita, additional, Rogak, Lauren J., additional, Reeve, Bryce B., additional, Snyder, Claire, additional, Bruner, Deborah, additional, Cella, David, additional, Kottschade, Lisa A., additional, Perlmutter, Jane, additional, Geoghegan, Cindy, additional, Samuel-Ryals, Cleo A., additional, Given, Barbara, additional, Mazza, Gina L., additional, Miller, Robert, additional, Strasser, Jon F., additional, Zylla, Dylan M., additional, Weiss, Anna, additional, Blinder, Victoria S., additional, and Dueck, Amylou C., additional

Published
2022
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14. Digital symptom monitoring with patient-reported outcomes in community oncology practices: A U.S. national cluster randomized trial.

Author

Basch, Ethan, primary, Schrag, Deborah, additional, Jansen, Jennifer, additional, Henson, Sydney, additional, Stover, Angela M., additional, Spears, Patricia, additional, Jonsson, Mattias, additional, Deal, Allison Mary, additional, Bennett, Antonia Vickery, additional, Thanarajasingam, Gita, additional, Reeve, Bryce, additional, Snyder, Claire Frances, additional, Bruner, Deborah, additional, Cella, David, additional, Kottschade, Lisa A., additional, Perlmutter, Jane, additional, Miller, Robert S., additional, Strasser, Jon F., additional, Zylla, Dylan M., additional, and Dueck, Amylou C., additional

Published
2021
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16. Phase 2 Study of a Temozolomide-Based Chemoradiation Therapy Regimen for High-Risk, Low-Grade Gliomas: Long-Term Results of Radiation Therapy Oncology Group 0424

Author

Fisher, Barbara J., primary, Pugh, Stephanie L., additional, Macdonald, David R., additional, Chakravatri, Arnab, additional, Lesser, Glenn J., additional, Fox, Sherry, additional, Rogers, C. Leland, additional, Werner-Wasik, Maria, additional, Doyle, Thomas, additional, Bahary, Jean-Paul, additional, Fiveash, John B., additional, Bovi, Joseph A., additional, Howard, Steven P., additional, Michael Yu, Hsiang-Hsuan, additional, D’Souza, David, additional, Laack, Nadia N., additional, Barani, Igor J., additional, Kwok, Young, additional, Wahl, Daniel R., additional, Strasser, Jon F., additional, Won, Minhee, additional, and Mehta, Minesh P., additional

Published
2020
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20. Utility of topical agents for radiation dermatitis and pain: a randomized clinical trial

Author

Ryan Wolf, Julie, primary, Gewandter, Jennifer S., additional, Bautista, Javier, additional, Heckler, Charles E., additional, Strasser, Jon, additional, Dyk, Pawal, additional, Anderson, Thomas, additional, Gross, Howard, additional, Speer, Tod, additional, Dolohanty, Lindsey, additional, Bylund, Kevin, additional, Pentland, Alice P., additional, and Morrow, Gary R., additional

Published
2019
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22. Impact of early FDG-PET directed intervention on preoperative therapy for locally advanced gastric cancer: A Cooperative Group random assignment phase II study (Alliance A021302) Impac.

Author

Shah, Manish A., primary, Shi, Qian, additional, Strong, Vivian E., additional, Strasser, Jon, additional, Ilson, David H., additional, Kleinberg, Lawrence, additional, Iqbal, Syma, additional, Wuthrick, Evan John, additional, Levasseur, Alexandra, additional, Hall, Nathan, additional, Meyerhardt, Jeffrey A., additional, and O'Reilly, Eileen Mary, additional

Published
2017
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24. In regard to Wu and Vapiwala et al

Author

Meyer, Joshua E., primary, Dilling, Thomas J., additional, Amdur, Robert J., additional, Strasser, Jon F., additional, Tendulkar, Rahul, additional, Lee, W. Robert, additional, Jani, Ashesh B., additional, Elshaikh, Mohamed, additional, Poppe, Matthew M., additional, Takita, Cristiane, additional, Currey, Adam, additional, Cheng, Simon K., additional, Jagsi, Reshma, additional, Kuo, Jeffrey V., additional, Chen, Allen M., additional, Dragun, Anthony E., additional, Bradley, Kristin, additional, Beriwal, Sushil, additional, Smith, Ryan P., additional, Chen, Ronald C., additional, Rosenzweig, Kenneth, additional, Kim, Sung, additional, and Mehta, Keyur, additional

Published
2016
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25. A prospective evaluation of radiotherapy (RT) related skin reactions in a multi-racial/ethnic population of women with newly diagnosed breast cancer (BC).

Author

Urbanic, James John, primary, Case, Doug, additional, Baez-Diaz, Luis, additional, Brown, Doris R., additional, Strasser, Jon, additional, Enevold, Gina, additional, Naughton, Michelle, additional, Weaver, Kathryn E, additional, Baglan, Kathy, additional, Bryant, David, additional, Langefeld, Carl, additional, Lad, Thomas E., additional, Lee, Lucille, additional, Rine, Grant, additional, Curtis, Amarinthia E., additional, Koprowski, Christoper D., additional, Tomlinson, W. Vic, additional, Lesser, Glenn Jay, additional, Shaw, Edward G., additional, and Hu, Jennifer J., additional

Published
2015
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27. Definitive radiotherapy versus Mohs surgery for early stage nonmelanoma skin cancers: a multi‐institutional retrospective comparison of local recurrence.

Author

Gasalberti, David, Ogrich, Lauren, Abdelmalek, Mark, and Strasser, Jon

Subjects
MOHS surgery, RADIOTHERAPY, SKIN cancer, DOUBLE-strand DNA breaks, BASAL cell carcinoma
Abstract

The article presents a case study of 365 patients with T1-2 squamous cell carcinomas (SCCs) and small basal cell carcinomas (BCCs). It notes the benefits of treatment with definitive radiotherapy (RT) versus Mohs surgery for early-stage nonmelanoma skin cancers of these patients. It also discusses that RT for basal cell carcinoma had similar 5-year local control rates compared to Mohs.

Published
2019
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28. Recurrence Rates by Age Stratification for Accelerated Partial Breast Irradiation Using Strut-Based Brachytherapy in Ductal Carcinoma In Situ Patients: A Report on 284 Patients

Author

Einck, John P., primary, Scanderbeg, Daniel J., additional, Kuske, Robert R., additional, Hong, Robert L., additional, Han, Ben, additional, Reiff, Jay E., additional, Mahalingam, Sudha B., additional, Nigh, Stephen S., additional, Strasser, Jon F., additional, Mantz, Constantine A., additional, Pollock, Jondavid, additional, Komarnicky, Lydia, additional, Finkelstein, Steven E., additional, and Yashar, Catheryn M., additional

Published
2014
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29. Frequency of Severe Valvular Disease Caused by Mediastinal Radiation Among Patients Undergoing Valve Surgery in a Community-Based, Regional Academic Medical Center

Author

Copeland, Kevin A., primary, Hosmane, Vinay R., additional, Jurkovitz, Claudine, additional, Kolm, Paul, additional, Bowen, Jim, additional, DiSabatino, Angela, additional, Banbury, Michael K., additional, Strasser, Jon F., additional, Weintraub, William S., additional, and Doorey, Andrew J., additional

Published
2013
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31. Outcomes for Accelerated Partial Breast Irradiation with a Strut-Based Brachytherapy Applicator: 320 Patients with at least 24-Month Followup

Author

Kuske, Robert R., primary, Han, Ben H., additional, Hong, Robert L., additional, Komarnicky, Lydia, additional, Lyden, Maureen, additional, Mahalingam, Sudha, additional, Mantz, Constantine A., additional, Nigh, Stephen, additional, Perry, Kerri, additional, Pollock, JonDavid, additional, Strasser, Jon, additional, and Yashar, Catheryn, additional

Published
2013
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32. FREQUENCY OF SEVERE VALVULAR DISEASE CAUSED BY MEDIASTINAL RADIATION AMONG PATIENTS UNDERGOING VALVE SURGERY IN A REGIONAL ACADEMIC MEDICAL CENTER

Author

Copeland, Kevin A., primary, Hosmane, Vinay R., additional, Jurkovitz, Claudine, additional, Kolm, Paul, additional, Bowen, James, additional, Strasser, Jon F., additional, Banbury, Michael K., additional, Gardner, Timothy J., additional, Weintraub, William S., additional, and Doorey, Andrew J., additional

Published
2011
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33. Reduce in Variation and Improve Efficiency of Target Volume Delineation by a Computer-Assisted System Using a Deformable Image Registration Approach

Author

Chao, K.S. Clifford, primary, Bhide, Shreerang, additional, Chen, Hansen, additional, Asper, Joshua, additional, Bush, Steven, additional, Franklin, Gregg, additional, Kavadi, Vivek, additional, Liengswangwong, Vichaivood, additional, Gordon, William, additional, Raben, Adam, additional, Strasser, Jon, additional, Koprowski, Christopher, additional, Frank, Steven, additional, Chronowski, Gregory, additional, Ahamad, Anesa, additional, Malyapa, Robert, additional, Zhang, Lifei, additional, and Dong, Lei, additional

Published
2007
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37. An unusual presentation of invasive squamous cell carcinoma of the upper extremities in a patient with a history of severe electrical burns and chronic thermal and chemical exposure.

Author

Chang BL, Chang A, Strasser J, Reinhardt JF, and Guarino M

Subjects
Burns, Electric epidemiology, Carcinoma, Squamous Cell epidemiology, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell therapy, Combined Modality Therapy, Dimethyl Sulfoxide, Humans, Male, Middle Aged, Occupational Exposure, Skin Neoplasms epidemiology, Skin Neoplasms pathology, Skin Neoplasms therapy, Solvents, Carcinoma, Squamous Cell diagnosis, Hand, Skin Neoplasms diagnosis
Abstract

This is a case report that depicts an atypical presentation of very aggressive, metachronous invasive squamous cell carcinomas of the upper extremities in a patient with no prior history of precancerous or cancerous skin lesions and no significant solar radiation exposure. Potentially causative factors that played a role in the emergence of this aggressive form of skin cancer in this case study are multifactorial: (1) chronic thermal exposure of 3000 degrees F daily to his hands for an eight to ten-year time period; (2) chronic chemical exposure of DMSO solvent and higher levels of chemical contaminants such and finally; (3) a form of chronic immunosuppression as a result of his severe electrical burns that resulted in widespread second and third burns throughout his body.

Published
2011

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