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49 results on '"Strauss, H. -G."'

2. 1524P Epidemiology and demography of gynecological sarcoma: Results of the prospective intergroup registry for gynecological sarcoma REGSA (NOGGO RU1)

Author

Roser, E., primary, Noack, A-S., additional, Zocholl, D., additional, Kommoss, S., additional, Harter, P., additional, Kalder, M., additional, Egger, E.K., additional, Buderath, P., additional, Marth, C., additional, Ulrich, U., additional, Klar, M., additional, Weigel, M., additional, Traub, L., additional, Strauß, H-G., additional, Hanker, L., additional, Pölcher, M., additional, Wimberger, P., additional, Beck, F., additional, Pietzner, K., additional, and Sehouli, J., additional

Published
2022
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3. 604P T cell density and immune phenotypes at the invasive margin correlate with prognosis in epithelial vulvar cancer

Author

Woelber, L., primary, Blessin, N.C., additional, Rolschewski, A-C., additional, Lutz, F., additional, Mandelkow, T., additional, Yang, C., additional, Bady, E., additional, Reiswich, V., additional, Simon, R., additional, Sauter, G., additional, Mahner, S., additional, De Gregorio, N., additional, Kalder, M., additional, Klapdor, R., additional, Braicu, I., additional, Fuerst, S., additional, Klar, M., additional, Strauß, H-G., additional, Burandt, E., additional, and Prieske, K., additional

Published
2022
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5. Uptake of hysterectomy and bilateral salpingooophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report

Author

Seppala, TT, Dominguez-Valentin, M, Crosbie, EJ, Engel, C, Aretz, S, Macrae, F, Winship, I, Capella, G, Thomas, H, Hovig, E, Nielsen, M, Sijmons, RH, Bertario, L, Bonanni, B, Tibiletti, MG, Cavestro, GM, Mints, M, Gluck, N, Katz, L, Heinimann, K, Vaccaro, CA, Green, K, Lalloo, F, Hill, J, Schmiegel, W, Vangala, D, Perne, C, Strauss, H-G, Tecklenburg, J, Holinski-Feder, E, Steinke-Lange, V, Mecklin, J-P, Plazzer, J-P, Pineda, M, Navarro, M, Vida, JB, Kariv, R, Rosner, G, Pinero, TA, Pavicic, W, Kalfayan, P, Ten Broeke, SW, Jenkins, MA, Sunde, L, Bernstein, I, Burn, J, Greenblatt, M, Cappel, WHDVTN, Della Valle, A, Lopez-Koestner, F, Alvarez, K, Buettner, R, Goergens, H, Morak, M, Holzapfel, S, Hueneburg, R, Doeberitz, MVK, Loeffler, M, Redler, S, Weitz, J, Pylvaenaeinen, K, Renkonen-Sinisalo, L, Lepisto, A, Hopper, JL, Win, AK, Lindor, NM, Gallinger, S, Marchand, LL, Newcomb, PA, Figueiredo, JC, Thibodeau, SN, Therkildsen, C, Wadt, KAW, Mourits, MJE, Ketabi, Z, Denton, OG, Rodland, EA, Vasen, H, Neffa, F, Esperon, P, Tjandra, D, Moeslein, G, Rokkones, E, Sampson, JR, Evans, DG, Moller, P, Seppala, TT, Dominguez-Valentin, M, Crosbie, EJ, Engel, C, Aretz, S, Macrae, F, Winship, I, Capella, G, Thomas, H, Hovig, E, Nielsen, M, Sijmons, RH, Bertario, L, Bonanni, B, Tibiletti, MG, Cavestro, GM, Mints, M, Gluck, N, Katz, L, Heinimann, K, Vaccaro, CA, Green, K, Lalloo, F, Hill, J, Schmiegel, W, Vangala, D, Perne, C, Strauss, H-G, Tecklenburg, J, Holinski-Feder, E, Steinke-Lange, V, Mecklin, J-P, Plazzer, J-P, Pineda, M, Navarro, M, Vida, JB, Kariv, R, Rosner, G, Pinero, TA, Pavicic, W, Kalfayan, P, Ten Broeke, SW, Jenkins, MA, Sunde, L, Bernstein, I, Burn, J, Greenblatt, M, Cappel, WHDVTN, Della Valle, A, Lopez-Koestner, F, Alvarez, K, Buettner, R, Goergens, H, Morak, M, Holzapfel, S, Hueneburg, R, Doeberitz, MVK, Loeffler, M, Redler, S, Weitz, J, Pylvaenaeinen, K, Renkonen-Sinisalo, L, Lepisto, A, Hopper, JL, Win, AK, Lindor, NM, Gallinger, S, Marchand, LL, Newcomb, PA, Figueiredo, JC, Thibodeau, SN, Therkildsen, C, Wadt, KAW, Mourits, MJE, Ketabi, Z, Denton, OG, Rodland, EA, Vasen, H, Neffa, F, Esperon, P, Tjandra, D, Moeslein, G, Rokkones, E, Sampson, JR, Evans, DG, and Moller, P

Abstract

PURPOSE: This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. METHODS: The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30-69 years. RESULTS: Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds of procedures before 50 years of age were combined hysterectomy and BSO, and 81% of all procedures included BSO. Risk-reducing hysterectomy was performed before age 50 years in 28%, 25%, 15%, and 9%, and BSO in 26%, 25%, 14% and 13% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 carriers, respectively. Before 50 years of age, 107 of 188 (57%) BSO and 126 of 204 (62%) hysterectomies were performed in women without any prior cancer, and only 5% (20/392) were performed simultaneously with colorectal cancer (CRC) surgery. CONCLUSION: Uptake of RRS before 50 years of age was low, and RRS was rarely undertaken in association with surgical treatment of CRC. Uptake of RRS aligned poorly with gene- and age-associated risk estimates for endometrial or ovarian cancer that were published recently from PLSD and did not correspond well with current clinical guidelines. The reasons should be clarified. Decision-making on opting for or against RRS and its timing should be better aligned with predicted risk and mortality for endometrial and ovarian cancer in Lynch syndrome to improve outcomes.

Published
2021

6. Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report

Author

Dominguez-Valentin, M, Crosbie, EJ, Engel, C, Aretz, S, Macrae, F, Winship, I, Capella, G, Thomas, H, Nakken, S, Hovig, E, Nielsen, M, Sijmons, RH, Bertario, L, Bonanni, B, Tibiletti, MG, Cavestro, GM, Mints, M, Gluck, N, Katz, L, Heinimann, K, Vaccaro, CA, Green, K, Lalloo, F, Hill, J, Schmiegel, W, Vangala, D, Perne, C, Strauss, H-G, Tecklenburg, J, Holinski-Feder, E, Steinke-Lange, V, Mecklin, J-P, Plazzer, J-P, Pineda, M, Navarro, M, Brunet Vidal, J, Kariv, R, Rosner, G, Alejandra Pinero, T, Laura Gonzalez, M, Kalfayan, P, Ryan, N, Ten Broeke, SW, Jenkins, MA, Sunde, L, Bernstein, I, Burn, J, Greenblatt, M, Cappel, WHDVTN, Della Valle, A, Lopez-Koestner, F, Alvarez, K, Buettner, R, Goergens, H, Morak, M, Holzapfel, S, Hueneburg, R, Doeberitz, MVK, Loeffler, M, Rahner, N, Weitz, J, Pylvanainen, K, Renkonen-Sinisalo, L, Lepisto, A, Auranen, A, Hopper, JL, Win, AK, Haile, RW, Lindor, NM, Gallinger, S, Le Marchand, L, Newcomb, PA, Figueiredo, JC, Thibodeau, SN, Therkildsen, C, Okkels, H, Ketabi, Z, Denton, OG, Rodland, EA, Vasen, H, Neffa, F, Esperon, P, Tjandra, D, Moeslein, G, Sampson, JR, Evans, DG, Seppala, TT, Moller, P, Dominguez-Valentin, M, Crosbie, EJ, Engel, C, Aretz, S, Macrae, F, Winship, I, Capella, G, Thomas, H, Nakken, S, Hovig, E, Nielsen, M, Sijmons, RH, Bertario, L, Bonanni, B, Tibiletti, MG, Cavestro, GM, Mints, M, Gluck, N, Katz, L, Heinimann, K, Vaccaro, CA, Green, K, Lalloo, F, Hill, J, Schmiegel, W, Vangala, D, Perne, C, Strauss, H-G, Tecklenburg, J, Holinski-Feder, E, Steinke-Lange, V, Mecklin, J-P, Plazzer, J-P, Pineda, M, Navarro, M, Brunet Vidal, J, Kariv, R, Rosner, G, Alejandra Pinero, T, Laura Gonzalez, M, Kalfayan, P, Ryan, N, Ten Broeke, SW, Jenkins, MA, Sunde, L, Bernstein, I, Burn, J, Greenblatt, M, Cappel, WHDVTN, Della Valle, A, Lopez-Koestner, F, Alvarez, K, Buettner, R, Goergens, H, Morak, M, Holzapfel, S, Hueneburg, R, Doeberitz, MVK, Loeffler, M, Rahner, N, Weitz, J, Pylvanainen, K, Renkonen-Sinisalo, L, Lepisto, A, Auranen, A, Hopper, JL, Win, AK, Haile, RW, Lindor, NM, Gallinger, S, Le Marchand, L, Newcomb, PA, Figueiredo, JC, Thibodeau, SN, Therkildsen, C, Okkels, H, Ketabi, Z, Denton, OG, Rodland, EA, Vasen, H, Neffa, F, Esperon, P, Tjandra, D, Moeslein, G, Sampson, JR, Evans, DG, Seppala, TT, and Moller, P

Abstract

PURPOSE: To determine impact of risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) on gynecological cancer incidence and death in heterozygotes of pathogenic MMR (path_MMR) variants. METHODS: The Prospective Lynch Syndrome Database was used to investigate the effects of gynecological risk-reducing surgery (RRS) at different ages. RESULTS: Risk-reducing hysterectomy at 25 years of age prevents endometrial cancer before 50 years in 15%, 18%, 13%, and 0% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 heterozygotes and death in 2%, 2%, 1%, and 0%, respectively. Risk-reducing BSO at 25 years of age prevents ovarian cancer before 50 years in 6%, 11%, 2%, and 0% and death in 1%, 2%, 0%, and 0%, respectively. Risk-reducing hysterectomy at 40 years prevents endometrial cancer by 50 years in 13%, 16%, 11%, and 0% and death in 1%, 2%, 1%, and 0%, respectively. BSO at 40 years prevents ovarian cancer before 50 years in 4%, 8%, 0%, and 0%, and death in 1%, 1%, 0%, and 0%, respectively. CONCLUSION: Little benefit is gained by performing RRS before 40 years of age and premenopausal BSO in path_MSH6 and path_PMS2 heterozygotes has no measurable benefit for mortality. These findings may aid decision making for women with LS who are considering RRS.

Published
2021

8. Age-dependent differences in borderline ovarian tumours (BOT) regarding clinical characteristics and outcome: results from a sub-analysis of the Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) ROBOT study

Author

Trillsch, F., Mahner, S., Woelber, L., Vettorazzi, E., Reuss, A., Ewald-Riegler, N., de Gregorio, N., Fotopoulou, C., Schmalfeldt, B., Burges, A., Hilpert, F., Fehm, T., Meier, W., Hillemanns, P., Hanker, L., Hasenburg, A., Strauss, H. G., Hellriegel, M., Wimberger, P., Baumann, K., Keyver-Paik, M. D., Canzler, U., Wollschlaeger, K., Forner, D., Pfisterer, J., Schroeder, W., Muenstedt, K., Richter, B., Kommoss, F., Hauptmann, S., and du Bois, A.

Published
2014
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9. Outcome parameters in node-negative vulvar cancer - a subset analysis of the AGO CaRE-1 study: ID 329

Author

Wölber, L., Jueckstock, J., Hilpert, F., Neuser, P., Harter, P., De Gregorio, N., Iborra, S., Sehouli, J., Habermann, A., Hillemanns, P., Fürst, S., Strauss, H.-G., Baumann, K. H., Thiel, F., Mustea, A., Meier, W., Du Bois, A., Wimberger, P., Hanker, L. C., Schmalfeldt, B., Canzler, U., Fehm, T., Luyten, A., Hellriegel, M., Kosse, J., Heiss, C., Hantschmann, P., Mallmann, P., Tanner, B., Pfisterer, J., Richter, B., Griebel, L.-F., and Mahner, S.

Published
2014

10. Importance of pelvic Lymphonodectomy in Squamous Cell Carcinoma of the Vulva (VSCC) Subgroup Analysis of the AGO-CaRE-1 Study

Author

Jueckstock, J., Fuerst, S., Bommert, M., Harter, P., Prieske, K., Eulenburg, C., Hilpert, F., deGregorio, N., Iborra, S., Sehouli, J., Ignatov, A., Hillemanns, P., Jaeger, A., Strauss, H-G, Baumann, K., Thiel, F., Mustea, A., Meier, W., Wimberger, P., Hanker, L., Schmalfeldt, B., Canzler, U., Fehm, T., Luyten, A., Hellriegel, M., Kosse, J., Heiss, C., Hantschmann, P., Mallmann, P., Tanner, B., Pfisterer, J., Woelber, L., Mahner, S., Jueckstock, J., Fuerst, S., Bommert, M., Harter, P., Prieske, K., Eulenburg, C., Hilpert, F., deGregorio, N., Iborra, S., Sehouli, J., Ignatov, A., Hillemanns, P., Jaeger, A., Strauss, H-G, Baumann, K., Thiel, F., Mustea, A., Meier, W., Wimberger, P., Hanker, L., Schmalfeldt, B., Canzler, U., Fehm, T., Luyten, A., Hellriegel, M., Kosse, J., Heiss, C., Hantschmann, P., Mallmann, P., Tanner, B., Pfisterer, J., Woelber, L., and Mahner, S.

Published
2020

11. The influence of age on treatment and prognosis of patients with squamous cell vulvar cancer (VSCC)- a subset analysis of the AGO-CaRE-1 study

Author

Prieske, K., Woelber, L., Muallem, M. Z., Eulenburg, C., Jueckstock, J., Hilpert, F., de Gregorio, N., Iborra, S., Ignatov, A., Hillemanns, P., Fuerst, S. T., Strauss, H. G., Baumann, K., Thiel, F., Mustea, A., Meier, W., Harter, P., Wimberger, P., Hanker, L., Schmalfeldt, B., Canzler, U., Fehm, T., Luyten, A., Hellriegel, M., Kosse, J., Heiss, C., Hantschmann, P., Mallmann, P., Tanner, B., Pfisterer, J., Sehouli, J., Mahner, S., Prieske, K., Woelber, L., Muallem, M. Z., Eulenburg, C., Jueckstock, J., Hilpert, F., de Gregorio, N., Iborra, S., Ignatov, A., Hillemanns, P., Fuerst, S. T., Strauss, H. G., Baumann, K., Thiel, F., Mustea, A., Meier, W., Harter, P., Wimberger, P., Hanker, L., Schmalfeldt, B., Canzler, U., Fehm, T., Luyten, A., Hellriegel, M., Kosse, J., Heiss, C., Hantschmann, P., Mallmann, P., Tanner, B., Pfisterer, J., Sehouli, J., and Mahner, S.

Published
2020

12. Risk-Reducing Gynecological Surgery in Lynch Syndrome: Results of an International Survey from the Prospective Lynch Syndrome Database

Author

Dominguez-Valentin, M, Seppala, TT, Engel, C, Aretz, S, Macrae, F, Winship, I, Capella, G, Thomas, H, Hovig, E, Nielsen, M, Sijmons, RH, Bertario, L, Bonanni, B, Tibiletti, MG, Cavestro, GM, Mints, M, Gluck, N, Katz, L, Heinimann, K, Vaccaro, CA, Green, K, Lalloo, F, Hill, J, Schmiegel, W, Vangala, D, Perne, C, Strauss, H-G, Tecklenburg, J, Holinski-Feder, E, Steinke-Lange, V, Mecklin, J-P, Plazzer, J-P, Pineda, M, Navarro, M, Vidal, JB, Kariv, R, Rosner, G, Alejandra Pinero, T, Laura Gonzalez, M, Kalfayan, P, Sampson, JR, Ryan, NAJ, Evans, DG, Moller, P, Crosbie, EJ, Dominguez-Valentin, M, Seppala, TT, Engel, C, Aretz, S, Macrae, F, Winship, I, Capella, G, Thomas, H, Hovig, E, Nielsen, M, Sijmons, RH, Bertario, L, Bonanni, B, Tibiletti, MG, Cavestro, GM, Mints, M, Gluck, N, Katz, L, Heinimann, K, Vaccaro, CA, Green, K, Lalloo, F, Hill, J, Schmiegel, W, Vangala, D, Perne, C, Strauss, H-G, Tecklenburg, J, Holinski-Feder, E, Steinke-Lange, V, Mecklin, J-P, Plazzer, J-P, Pineda, M, Navarro, M, Vidal, JB, Kariv, R, Rosner, G, Alejandra Pinero, T, Laura Gonzalez, M, Kalfayan, P, Sampson, JR, Ryan, NAJ, Evans, DG, Moller, P, and Crosbie, EJ

Abstract

PURPOSE: To survey risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) practice and advice regarding hormone replacement therapy (HRT) in women with Lynch syndrome. METHODS: We conducted a survey in 31 contributing centers from the Prospective Lynch Syndrome Database (PLSD), which incorporates 18 countries worldwide. The survey covered local policies for risk-reducing hysterectomy and BSO in Lynch syndrome, the timing when these measures are offered, the involvement of stakeholders and advice regarding HRT. RESULTS: Risk-reducing hysterectomy and BSO are offered to path_MLH1 and path_MSH2 carriers in 20/21 (95%) contributing centers, to path_MSH6 carriers in 19/21 (91%) and to path_PMS2 carriers in 14/21 (67%). Regarding the involvement of stakeholders, there is global agreement (~90%) that risk-reducing surgery should be offered to women, and that this discussion may involve gynecologists, genetic counselors and/or medical geneticists. Prescription of estrogen-only HRT is offered by 15/21 (71%) centers to women of variable age range (35-55 years). CONCLUSIONS: Most centers offer risk-reducing gynecological surgery to carriers of path_MLH1, path_MSH2 and path_MSH6 variants but less so for path_PMS2 carriers. There is wide variation in how, when and to whom this is offered. The Manchester International Consensus Group developed recommendations to harmonize clinical practice across centers, but there is a clear need for more research.

Published
2020

13. DEGRO 2004: 10. Jahreskongress der Deutschen Gesellschaft für Radioonkologie

Author

Wendt, Thomas G., Gademann, G., Pambor, C., Grießbach, I., von Specht, H., Martin, T., Baltas, D., Kurek, R., Röddiger, S., Tunn, U. W., Zamboglou, N., Eich, H. T., Staar, S., Gossmann, A., Hansemann, K., Semrau, R., Skripnitchenko, R., Diehl, V., Müller, R.-P., Sehlen, S., Willich, N., Rühl, U., Lukas, P., Dühmke, E., Engel, K., Tabbert, E., Bolck, M., Knaack, S., Annweiler, H., Krempien, R., Hoppe, H., Harms, W., Daeuber, S., Schorr, O., Treiber, M., Debus, J., Alber, M., Paulsen, F., Birkner, M., Bakai, A., Belka, C., Budach, W., Grosser, K.-H., Kramer, R., Kober, B., Reinert, M., Schneider, P., Hertel, A., Feldmann, H., Csere, P., Hoinkis, C., Rothe, G., Zahn, P., Alheit, H., Cavanaugh, S. X., Kupelian, P., Reddy, C., Pollock, B., Fuss, M., Roeddiger, S., Dannenberg, T., Rogge, B., Drechsler, D., Herrmann, T., Alberti, W., Schwarz, R., Graefen, M., Krüll, A., Rudat, V., Huland, H., Fehr, C., Baum, C., Glocker, S., Nüsslin, F., Heil, T., Lemnitzer, H., Knips, M., Baumgart, O., Thiem, W., Kloetzer, K.-H., Hoffmann, L., Neu, B., Hültenschmidt, B., Sautter-Bihl, M.-L., Micke, O., Seegenschmiedt, M. H., Köppen, D., Klautke, G., Fietkau, R., Schultze, J., Schlichting, G., Koltze, H., Kimmig, B., Glatzel, M., Fröhlich, D., Bäsecke, S., Krauß, A., Strauß, D., Buth, K.-J., Böhme, R., Oehler, W., Bottke, D., Keilholz, U., Heufelder, K., Wiegel, T., Hinkelbein, W., Rödel, C., Papadopoulos, T., Munnes, M., Wirtz, R., Sauer, R., Rödel, F., Lubgan, D., Distel, L., Grabenbauer, G. G., Sak, A., Stüben, G., Pöttgen, C., Grehl, S., Stuschke, M., Müller, K., Pfaffendorf, C., Mayerhofer, A., Köhn, F. M., Ring, J., van Beuningen, D., Meineke, V., Neubauer, S., Keller, U., Wittlinger, M., Riesenbeck, D., Greve, B., Exeler, R., Ibrahim, M., Liebscher, C., Severin, E., Ott, O., Pötter, R., Hammer, J., Hildebrandt, G., Beckmann, M. W., Strnad, V., Fehlauer, F., Tribius, S., Bajrovic, A., Höller, U., Rades, D., Warszawski, A., Baumann, R., Madry-Gevecke, B., Karstens, J. H., Grehn, C., Hensley, F., Berns, C., Wannenmacher, M., Semrau, S., Reimer, T., Gerber, B., Ketterer, P., Koepcke, E., Hänsgen, G., Strauß, H. G., Dunst, J., Füller, J., Kalb, S., Wendt, T., Weitmann, H. D., Waldhäusl, C., Knocke, T.-H., Lamprecht, U., Classen, J., Kaulich, T. W., Aydeniz, B., Bamberg, M., Wiezorek, T., Banz, N., Salz, H., Scheithauer, M., Schwedas, M., Lutterbach, J., Bartelt, S., Frommhold, H., Lambert, J., Hornung, D., Swiderski, S., Walke, M., Siefert, A., Pöllinger, B., Krimmel, K., Schaffer, M., Koelbl, O., Bratengeier, K., Vordermark, D., Flentje, M., Hero, B., Berthold, F., Combs, S. E., Gutwein, S., Schulz-Ertner, D., van Kampen, M., Thilmann, C., Kocher, M., Kunze, S., Schild, S., Ikezaki, K., Müller, B., Sieber, R., Weiß, C., Wolf, I., Wenz, F., Weber, K.-J., Schäfer, J., Engling, A., Laufs, S., Veldwijk, M. R., Milanovic, D., Fleckenstein, K., Zeller, W., Fruehauf, S., Herskind, C., Weinmann, M., Jendrossek, V., Rübe, C., Appold, S., Kusche, S., Hölscher, T., Brüchner, K., Geyer, P., Baumann, M., Kumpf, R., Zimmermann, F., Schill, S., Geinitz, H., Nieder, C., Jeremic, B., Molls, M., Liesenfeld, S., Petrat, H., Hesselmann, S., Schäfer, U., Bruns, F., Horst, E., Wilkowski, R., Assmann, G., Nolte, A., Diebold, J., Löhrs, U., Fritz, P., Hans-Jürgen, K., Mühlnickel, W., Bach, P., Wahlers, B., Kraus, H.-J., Wulf, J., Hädinger, U., Baier, K., Krieger, T., Müller, G., Hof, H., Herfarth, K., Brunner, T., Hahn, S. M., Schreiber, F. S., Rustgi, A. K., McKenna, W. G., Bernhard, E. J., Guckenberger, M., Meyer, K., Willner, J., Schmidt, M., Kolb, M., Li, M., Gong, P., Abdollahi, A., Trinh, T., Huber, P. E., Christiansen, H., Saile, B., Neubauer-Saile, K., Tippelt, S., Rave-Fränk, M., Hermann, R. M., Dudas, J., Hess, C. F., Schmidberger, H., Ramadori, G., Andratschke, N., Price, R., Ang, K.-K., Schwarz, S., Kulka, U., Busch, M., Schlenger, L., Bohsung, J., Eichwurzel, I., Matnjani, G., Sandrock, D., Richter, M., Wurm, R., Budach, V., Feussner, A., Gellermann, J., Jordan, A., Scholz, R., Gneveckow, U., Maier-Hauff, K., Ullrich, R., Wust, P., Felix, R., Waldöfner, N., Seebass, M., Ochel, H.-J., Dani, A., Varkonyi, A., Osvath, M., Szasz, A., Messer, P. M., Blumstein, N. M., Gottfried, H.-W., Schneider, E., Reske, S. N., Röttinger, E. M., Grosu, A.-L., Franz, M., Stärk, S., Weber, W., Heintz, M., Indenkämpen, F., Beyer, T., Lübcke, W., Levegrün, S., Hayen, J., Czech, N., Mbarek, B., Köster, R., Thurmann, H., Todorovic, M., Schuchert, A., Meinertz, T., Münzel, T., Grundtke, H., Hornig, B., Hehr, T., Dilcher, C., Chan, R. C., Mintz, G. S., Kotani, J.-I., Shah, V. M., Canos, D. A., Weissman, N. J., Waksman, R., Wolfram, R., Bürger, B., Schrappe, M., Timmermann, B., Lomax, A., Goitein, G., Schuck, A., Mattke, A., Int-Veen, C., Brecht, I., Bernhard, S., Treuner, J., Koscielniak, E., Heinze, F., Kuhlen, M., von Schorlemer, I., Ahrens, S., Hunold, A., Könemann, S., Winkelmann, W., Jürgens, H., Gerstein, J., Polivka, B., Sykora, K.-W., Bremer, M., Thamm, R., Höpfner, C., Gumprecht, H., Jäger, R., Leonardi, M. A., Frank, A. M., Trappe, A. E., Lumenta, C. B., Östreicher, E., Pinsker, K., Müller, A., Fauser, C., Arnold, W., Henzel, M., Groß, M. W., Engenhart-Cabillic, R., Schüller, P., Palkovic, S., Schröder, J., Wassmann, H., Block, A., Bauer, R., Keffel, F.-W., Theophil, B., Wisser, L., Rogger, M., Niewald, M., van Lengen, V., Mathias, K., Welzel, G., Bohrer, M., Steinvorth, S., Schleußner, C., Leppert, K., Röhrig, B., Strauß, B., van Oorschot, B., Köhler, N., Anselm, R., Winzer, A., Schneider, T., Koch, U., Schönekaes, K., Mücke, R., Büntzel, J., Kisters, K., Scholz, C., Keller, M., Winkler, C., Prause, N., Busch, R., Roth, S., Haas, I., Willers, R., Schultze-Mosgau, S., Wiltfang, J., Kessler, P., Neukam, F. W., Röper, B., Nüse, N., Auer, F., Melzner, W., Geiger, M., Lotter, M., Kuhnt, T., Müller, A. C., Jirsak, N., Gernhardt, C., Schaller, H.-G., Al-Nawas, B., Klein, M. O., Ludwig, C., Körholz, J., Grötz, K. A., Huppers, K., Kunkel, M., Olschewski, T., Bajor, K., Lang, B., Lang, E., Kraus-Tiefenbacher, U., Hofheinz, R., von Gerstenberg-Helldorf, B., Willeke, F., Hochhaus, A., Roebel, M., Oertel, S., Riedl, S., Buechler, M., Foitzik, T., Ludwig, K., Klar, E., Meyer, A., Meier zu Eissen, J., Schwab, D., Meyer, T., Höcht, S., Siegmann, A., Sieker, F., Pigorsch, S., Milicic, B., Acimovic, L., Milisavljevic, S., Radosavljevic-Asic, G., Presselt, N., Baum, R. P., Treutler, D., Bonnet, R., Schmücking, M., Sammour, D., Fink, T., Ficker, J., Pradier, O., Lederer, K., Weiss, E., Hille, A., Welz, S., Sepe, S., Friedel, G., Spengler, W., Susanne, E., Kölbl, O., Hoffmann, W., Wörmann, B., Günther, A., Becker-Schiebe, M., Güttler, J., Schul, C., Nitsche, M., Körner, M. K., Oppenkowski, R., Guntrum, F., Malaimare, L., Raub, M., Schöfl, C., Averbeck, T., Hacker, I., Blank, H., Böhme, C., Imhoff, D., Eberlein, K., Weidauer, S., Böttcher, H. D., Edler, L., Tatagiba, M., Molina, H., Ostertag, C., Milker-Zabel, S., Zabel, A., Schlegel, W., Hartmann, A., Wildfang, I., Kleinert, G., Hamm, K., Reuschel, W., Wehrmann, R., Kneschaurek, P., Münter, M. W., Nikoghosyan, A., Didinger, B., Nill, S., Rhein, B., Küstner, D., Schalldach, U., Eßer, D., Göbel, H., Wördehoff, H., Pachmann, S., Hollenhorst, H., Dederer, K., Evers, C., Lamprecht, J., Dastbaz, A., Schick, B., Fleckenstein, J., Plinkert, P. K., Rübe, Chr., Merz, T., Sommer, B., Mencl, A., Ghilescu, V., Astner, S., Martin, A., Momm, F., Volegova-Neher, N. J., Schulte-Mönting, J., Guttenberger, R., Buchali, A., Blank, E., Sidow, D., Huhnt, W., Gorbatov, T., Heinecke, A., Beckmann, G., Bentia, A.-M., Schmitz, H., Spahn, U., Heyl, V., Prott, P.-J., Galalae, R., Schneider, R., Voith, C., Scheda, A., Hermann, B., Bauer, L., Melchert, F., Kröger, N., Grüneisen, A., Jänicke, F., Zander, A., Zuna, I., Schlöcker, I., Wagner, K., John, E., Dörk, T., Lochhas, G., Houf, M., Lorenz, D., Link, K.-H., Prott, F.-J., Thoma, M., Schauer, R., Heinemann, V., Romano, M., Reiner, M., Quanz, A., Oppitz, U., Bahrehmand, R., Tine, M., Naszaly, A., Patonay, P., Mayer, Á., Markert, K., Mai, S.-K., Lohr, F., Dobler, B., Pinkawa, M., Fischedick, K., Treusacher, P., Cengiz, D., Mager, R., Borchers, H., Jakse, G., Eble, M. J., Asadpour, B., Krenkel, B., Holy, R., Kaplan, Y., Block, T., Czempiel, H., Haverkamp, U., Prümer, B., Christian, T., Benkel, P., Weber, C., Gruber, S., Reimann, P., Blumberg, J., Krause, K., Fischedick, A.-R., Kaube, K., Steckler, K., Henzel, B., Licht, N., Loch, T., Krystek, A., Lilienthal, A., Alfia, H., Claßen, J., Spillner, P., Knutzen, B., Souchon, R., Schulz, I., Grüschow, K., Küchenmeister, U., Vogel, H., Wolff, D., Ramm, U., Licner, J., Rudolf, F., Moog, J., Rahl, C. G., Mose, S., Vorwerk, H., Weiß, E., Engert, A., Seufert, I., Schwab, F., Dahlke, J., Zabelina, T., Krüger, W., Kabisch, H., Platz, V., Wolf, J., Pfistner, B., Stieltjes, B., Wilhelm, T., Schmuecking, M., Junker, K., Treutier, D., Schneider, C. P., Leonhardi, J., Niesen, A., Hoeffken, K., Schmidt, A., Mueller, K.-M., Schmid, I., Lehmann, K., Blumstein, C. G., Kreienberg, R., Freudenberg, L., Kühl, H., Stahl, M., Elo, B., Erichsen, P., Stattaus, H., Welzel, T., Mende, U., Heiland, S., Salter, B. J., Schmid, R., Stratakis, D., Huber, R. M., Haferanke, J., Zöller, N., Henke, M., Lorenzen, J., Grzyska, B., Kuhlmey, A., Adam, G., Hamelmann, V., Bölling, T., Job, H., Panke, J. E., Feyer, P., Püttmann, S., Siekmeyer, B., Jung, H., Gagel, B., Militz, U., Piroth, M., Schmachtenberg, A., Hoelscher, T., Verfaillie, C., Kaminski, B., Lücke, E., Mörtel, H., Eyrich, W., Fritsch, M., Georgi, J.-C., Plathow, C., Zieher, H., Kiessling, F., Peschke, P., Kauczor, H.-U., Licher, J., Schneider, O., Henschler, R., Seidel, C., Kolkmeyer, A., Nguyen, T. P., Janke, K., Michaelis, M., Bischof, M., Stoffregen, C., Lipson, K., Weber, K., Ehemann, V., Jürgen, D., Achanta, P., Thompson, K., Martinez, J. L., Körschgen, T., Pakala, R., Pinnow, E., Hellinga, D., O’Tio, F., Katzer, A., Kaffer, A., Kuechler, A., Steinkirchner, S., Dettmar, N., Cordes, N., Frick, S., Kappler, M., Taubert, H., Bartel, F., Schmidt, H., Bache, M., Frühauf, S., Wenk, T., Litzenberger, K., Erren, M., van Valen, F., Liu, L., Yang, K., Palm, J., Püsken, M., Behe, M., Behr, T. M., Marini, P., Johne, A., Claussen, U., Liehr, T., Steil, V., Moustakis, C., Griessbach, I., Oettel, A., Schaal, C., Reinhold, M., Strasssmann, G., Braun, I., Vacha, P., Richter, D., Osterham, T., Wolf, P., Guenther, G., Miemietz, M., Lazaridis, E. A., Forthuber, B., Sure, M., Klein, J., Saleske, H., Riedel, T., Hirnle, P., Horstmann, G., Schoepgens, H., Van Eck, A., Bundschuh, O., Van Oosterhut, A., Xydis, K., Theodorou, K., Kappas, C., Zurheide, J., Fridtjof, N., Ganswindt, U., Weidner, N., Buchgeister, M., Weigel, B., Müller, S. B., Glashörster, M., Weining, C., Hentschel, B., Sauer, O. A., Kleen, W., Beck, J., Lehmann, D., Ley, S., Fink, C., Puderbach, M., Hosch, W., Schmähl, A., Jung, K., Stoßberg, A., Rolf, E., Damrau, M., Oetzel, D., Maurer, U., Maurer, G., Lang, K., Zumbe, J., Hahm, D., Fees, H., Robrandt, B., Melcher, U., Niemeyer, M., Mondry, A., Kanellopoulos-Niemeyer, V., Karle, H., Jacob-Heutmann, D., Born, C., Mohr, W., Kutzner, J., Thelen, M., Schiebe, M., Pinkert, U., Piasswilm, L., Pohl, F., Garbe, S., Wolf, K., Nour, Y., Barwig, P., Trog, D., Schäfer, C., Herbst, M., Dietl, B., Cartes, M., Schroeder, F., Sigingan-Tek, G., Feierabend, R., Theden, S., Schlieck, A., Gotthardt, M., Glowalla, U., Kremp, S., Hamid, O., Riefenstahl, N., Michaelis, B., Schaal, G., Liebermeister, E., Niewöhner-Desbordes, U., Kowalski, M., Franz, N., Stahl, W., Baumbach, C., Thale, J., Wagner, W., Justus, B., Huston, A. L., Seaborn, R., Rai, P., Rha, S.-W., Sakas, G., Wesarg, S., Zogal, P., Schwald, B., Seibert, H., Berndt-Skorka, R., Seifert, G., Schoenekaes, K., Bilecen, C., Ito, W., Matschuck, G., and Isik, D.

Published
2004
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14. Bedeutung der pelvinen Lymphonodektomie beim Plattenepithelkarzinom der Vulva (VSCC) – Subgruppenanalyse der AGO-CaRE-1 Studie

Author

Jueckstock, J, additional, Fuerst, S, additional, Bommert, M, additional, Harter, P, additional, Prieske, K, additional, Eulenburg, C, additional, Hilpert, F, additional, deGregorio, N, additional, Iborra, S, additional, Sehouli, J, additional, Ignatov, A, additional, Hillemanns, P, additional, Jaeger, A, additional, Strauss, H-G, additional, Baumann, K, additional, Thiel, F, additional, Mustea, A, additional, Meier, W, additional, Wimberger, P, additional, Hanker, L, additional, Schmalfeldt, B, additional, Canzler, U, additional, Fehm, T, additional, Luyten, A, additional, Hellriegel, M, additional, Kosse, J, additional, Heiss, C, additional, Hantschmann, P, additional, Mallmann, P, additional, Tanner, B, additional, Pfisterer, J, additional, Woelber, L, additional, and Mahner, S, additional

Published
2020
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15. P193 p53 and p16 expression profiles identify three prognostically subgroups in vulvar cancer : a TMA based study by the AGO-CaRE-translational study group : Poster exhibition Day 2

Author

Wölber, L., Prieske, K., Eulenburg, C., Gregorio, N. de, Klapdor, R., Kalder, M., Braicu, I., Fuerst, S., Klar, M., Strauss, H.-G., Mehlhorn, G., Meier, W., Ignatov, A., Mustea, A., Jueckstock, J., Schmidt, G., Bauerschlag, D., Hellriegel, M., Canzler, U., Luyten, A., Kommoss, S., Hantschmann, P., Heubner, Martin, Mahner, S., and Burandt, E.

Subjects
Medizin, ComputingMethodologies_GENERAL
Abstract

Poster

Published
2019

17. P193 p53 and p16 expression profiles identify three prognostically subgroups in vulvar cancer: a TMA based study by the AGO-CaRE-translational study group

Author

Wölber, L, primary, Prieske, K, additional, Eulenburg, C, additional, de Gregorio, N, additional, Klapdor, R, additional, Kalder, M, additional, Braicu, I, additional, Fuerst, S, additional, Klar, M, additional, Strauss, H-G, additional, Mehlhorn, G, additional, Meier, W, additional, Ignatov, A, additional, Mustea, A, additional, Jueckstock, J, additional, Schmidt, G, additional, Bauerschlag, D, additional, Hellriegel, M, additional, Canzler, U, additional, Luyten, A, additional, Kommoss, S, additional, Hantschmann, P, additional, Heubner, M, additional, Mahner, S, additional, Burandt, E, additional, and Study Group, AGO, additional

Published
2019
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20. Outcome parameters in node-negative vulvar cancer - subset analysis of the AGO CaRE-1 study

Author

Wolber, L., Jueckstock, J., Hilpert, F., Neuser, P., Harter, P., De Gregorio, N., Iborra, S., Sehouli, J., Habermann, A., Hillemanns, P., Furst, S., Strauss, H. G., Baumann, K. H., Thiel, F., Mustea, A., Meier, W., Du Bois, A., Wimberger, Pauline, Hanker, L. C., Schmalfeldt, B., Canzler, U., Fehm, T., Luyten, A., Hellriegel, M., Kosse, J., Heiss, C., Hantschmann, P., Mallmann, P., Tanner, B., Pfisterer, J., Richter, B., Griebel, L. F., and Mahner, S.

Subjects
Medizin
Published
2014

21. AGO Vulva CaRE-1 multicenter study - adjuvant radio(chemo)therapy in vulvar cancer

Author

Hillemanns, P., Wolber, L., Juckstock, J., Neuser, P., Hilpert, F., Harter, P., De Gregorio, N., Hasenburg, A., Sehouli, J., Habermann, A., Fuerst, S. T., Strauss, H. G., Baumann, K., Thiel, F., Mustea, A., Meier, W., Du Bois, A., Wimberger, Pauline, Hanker, L., Schmalfeldt, B., Canzler, U., Fehm, T., Luyten, A., Hellriegel, M., Kosse, J., Heiss, C., Hantschmann, P., Mallmann, P., Tanner, B., Pfisterer, J., Richter, B., Petersen, C., and Mahner, S.

Subjects
Medizin
Published
2014

22. Prognostic impact of the time interval between primary and re-staging surgery in patients with borderline ovarian tumours (BOT) : An analysis of the Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) Study Group

Author

Trillsch, F., Mahner, S., Rutzel, J. D., Vettorazzi, E., Reuss, A., Hillemanns, P., Hanker, L., Hasenburg, A., Strauss, H. G., Hellriegel, M., Wimberger, Pauline, Klaus, B., Keyver-Paik, M. D., Canzler, U., Wollschlaeger, K., Forner, D., Pfisterer, J., Schroder, W., Munstedt, K., Richter, B., Fotopoulou, C., Schmalfeldt, B., Burges, A., Fehm, T., Meier, W., Ewald-Riegler, N., De Gregorio, N., Hilpert, F., and Du Bois, A.

Subjects
Medizin
Published
2014

23. Sarcoma of the Uterus. Guideline of the DGGG (S2k-Level, AWMF Registry No. 015/074, August 2015)

Author

Denschlag, D., Thiel, F. C., Ackermann, S., Harter, P., Juhasz-Boess, I., Mallmann, P., Strauss, H. -G., Ullrich, U., Horn, L. -C., Schmidt, D., Vordermark, D., Vogl, T., Reichardt, P., Gass, P., Gebhardt, M., Beckmann, M. W., Denschlag, D., Thiel, F. C., Ackermann, S., Harter, P., Juhasz-Boess, I., Mallmann, P., Strauss, H. -G., Ullrich, U., Horn, L. -C., Schmidt, D., Vordermark, D., Vogl, T., Reichardt, P., Gass, P., Gebhardt, M., and Beckmann, M. W.

Abstract

Purpose: Official guideline published and coordinated by the German Society of Gynecology and Obstetrics (DGGG). Due to their rarity and their heterogeneous histopathology uterine sarcomas remain challenging tumors to manage and need a multidisciplinary approach. To our knowledge so far there is no evidence-based guideline on the appropiate management of these heterogeneous tumors. Methods: This S2k-guideline is the work of an representative committee of experts from a variety of different professions who were commissioned by the DGGG to carry out a systematic literature review of uterine sarcoma. Members of the participating scientific societies developed a structured consensus in a formal procedure. Recommendations: 1. The incidence and histopathologic classification of uterine sarcoma. 2. The clinical manifestations, diagnosis and staging of uterine sarcoma. 3. The management of leiomyosarcoma. 4. The management of endometrial stromal sarcoma and undifferentiated uterine sarcoma. 5. The management of adenosarcoma as well as carcinosarcomas. 6. The management of morcellated uterine sarcoma

Published
2015

24. Sarcoma of the Uterus. Guideline of the DGGG (S2k-Level, AWMF Registry No. 015/074, August 2015)

Author

Denschlag, D., additional, Thiel, F., additional, Ackermann, S., additional, Harter, P., additional, Juhasz-Boess, I., additional, Mallmann, P., additional, Strauss, H.-G., additional, Ulrich, U., additional, Horn, L.-C., additional, Schmidt, D., additional, Vordermark, D., additional, Vogl, T., additional, Reichardt, P., additional, Gaß, P., additional, Gebhardt, M., additional, and Beckmann, M., additional

Published
2015
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25. Surgical staging and prognosis in serous borderline ovarian tumours (BOT): A subanalysis of the AGO ROBOT study

Author

Trillsch, F, primary, Mahner, S, additional, Vettorazzi, E, additional, Woelber, L, additional, Reuss, A, additional, Baumann, K, additional, Keyver-Paik, M-D, additional, Canzler, U, additional, Wollschlaeger, K, additional, Forner, D, additional, Pfisterer, J, additional, Schroeder, W, additional, Muenstedt, K, additional, Richter, B, additional, Fotopoulou, C, additional, Schmalfeldt, B, additional, Burges, A, additional, Ewald-Riegler, N, additional, de Gregorio, N, additional, Hilpert, F, additional, Fehm, T, additional, Meier, W, additional, Hillemanns, P, additional, Hanker, L, additional, Hasenburg, A, additional, Strauss, H-G, additional, Hellriegel, M, additional, Wimberger, P, additional, Kommoss, S, additional, Kommoss, F, additional, Hauptmann, S, additional, and du Bois, A, additional

Published
2015
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26. Outcome parameters in node-negative vulvar cancer - subset analysis of the AGO CaRE-1 study

Author

Woelber, L., Jueckstock, J., Hilpert, F., Neuser, P., Harter, P., De Gregorio, N., Iborra, S., Sehouli, J., Habermann, A., Hillemanns, P., Fuerst, S., Strauss, H. -G., Baumann, K. H., Thiel, F., Mustea, A., Meier, W., Du Bois, A., Wimberger, P., Hanker, L. C., Schmalfeldt, B., Canzler, U., Fehm, T., Luyten, A., Hellriegel, M., Kosse, J., Heiss, C., Hantschmann, P., Mallmann, P., Tanner, B., Pfisterer, J., Richter, B., Griebel, L. -F., Mahner, S., Woelber, L., Jueckstock, J., Hilpert, F., Neuser, P., Harter, P., De Gregorio, N., Iborra, S., Sehouli, J., Habermann, A., Hillemanns, P., Fuerst, S., Strauss, H. -G., Baumann, K. H., Thiel, F., Mustea, A., Meier, W., Du Bois, A., Wimberger, P., Hanker, L. C., Schmalfeldt, B., Canzler, U., Fehm, T., Luyten, A., Hellriegel, M., Kosse, J., Heiss, C., Hantschmann, P., Mallmann, P., Tanner, B., Pfisterer, J., Richter, B., Griebel, L. -F., and Mahner, S.

Published
2014

30. Autorenverzeichnis

Author

Andresen, V., Angenendt, J., Anthoni, C., Appenrodt, B., Arbogast, M., Arco, G., Atta, J., Auer, M., Auernhammer, C., Autenrieth, I.B., Avenhaus, W., Bachem, R., Backmund, M., Bänsch, D., Ballauff, A., Baltzer, J., Barth, J., Batra, A., Bazarra-Castro, M.A., Beck, S., Becker, K., Becker, Karsten, Behr, J., Behrens, A., Belyaev, O., Bender-Götze, Ch., Bengel, J., Benz, M., Haunerschen, von, Berberich, J., Berger, M., Berner, R., Berr, F., S.C., Blank, N., Bleh, C., Blind, Eberhard, Blum, H.E., Bock, N., Bockhorn, M., Böhler, J., Böhm, M., Bokemeyer, D., Bönner, G., Bork, K., Born, G., Brandt, Thomas, Braun, J., Bruch, H.-P., Brümmendorf, T.H., Brüwer, M., Brunnberg, U., Buchfelder, M., Buchkremer, G., Büchler, M.W., Carl, H.-D., Castell, S., Daniels, C., Daum, S., Detter, C., Deuschl, G., Dieckmann, E., Diederich, S., Diehm, C., Diemer, T., Diener, H.C., Diepolder, H., Distler, J., Dörner, T., Prof. Dr., Domagk, D., Domschke, W., Dragu, A., Dralle, H., Dreyling, M., van, P., Dürk, T., Ebert, D., Ehlebracht-König, I., Elger, C.E., Ell, C., Ellinger, J., Emons, G., Engel, O., Enzensberger, W., Epple, H.-J., Erbel, R., Fassnacht, M., Feußner, Hubertus, Fichter, M., Fiegel, P., Filipas, D., Fisang, C., Fisch, M., Fischbach, W., Fischer, N., Fischer, M., Flamme, C.H., Fleckenstein, K., Floege, J., Fluhr, G., Fölsch, U.R., Forsting, M., Fottner, C., Frank, W., Frey, N., Freyberger, H., Friese, K., Frilling, A., habil, PD. Dr., Frommberger, U., Frühmorgen, P., Fuss, Johannes, Gätje, R., Galle, P.R., Geidel, S., Geiß, H.-Ch., Genth, Ekkehard, Gilsbach, J.M., Gingelmaier, A., Goebel, F.-D., Göhl, J., Gökbuget, N., Gold, R., Gonzalez-Carmona, M.A., Gossé, F., Grabitz, K., Greetfeld, M., Gries, F.A., Grosch-Wörner, I., Grüner, N., Grünke, M., Grüters-Kieslich, A., Gülberg, V., Haak, T., Häfner, R., Härter, M., Hagenacker, T., Hahn, S., Hahner, S., Haidl, G., Hammer, M., Hammersen, F., Handrick, W., Hanisch, F., Hansen, M.P., Hanke, Sara, Haschka, J., Hasslacher, C., Hauer, Th., Hauptmann, A., Heckmann, M., Heidbreder, E., Heim, U., Heindel, W., Heitmann, J., Hegenbart, U., Hermann, W., Herrmann, J.M., Herpertz-Dahlmann, B., Heßlinger, B., Heuß, D., Heußner, P., Hiller, E., Hirner, A., Hölscher, A.H., Hölzen, J., Hörl<ce:sup loc='post">†</ce:sup>, W.H., Hörle, S., Hof, H., Hofmann, W.-K., Hohenberger, W., Hohenfellner, U., Holler, E., Holtmann, G., Honegger, J., Hopf, H.C., Horch, R.E., Hornke, I., Hornung, T., Huber, R.M., Hueber, A., Hübner, J., Hummel, R., Irmscher, S., Janßen, O.E., Jelinek, T., Jendrissek, K.A., Jonas, S., Jost, E., Jung, H.H., Kahaly, G.J., Kalden, J.R., Kalff, J., Kapellen, T., Karaus, M., Kastrup, O., Katsoulis, S., Katus, H., Kaudel, C.P., Kaulitz, R., Keck, C., Keller, F., Kellnar, S., Kiehne, K., Kiess, W., Kindermann, M., Kirschbaum, A., Klein, M., Kleindienst, A., Kneitz, C., von Kodolitsch, Y., Köhler, D., Kessler, H.P., Köhler, G., Köhler, H., Köhler, L., Köhler, M., Köhnke, M., Königs, C., Köninger, J., Könsgen-Mustea, D., Köster, R., Kötter, I., Kohne, E., Kolb, H.-J., Koletzko, S., Kollmar, R., Konstantinidis, S., Koop, K., Kopp, H.G., Koschinsky, T., Kramer, H.J., Krauss, J., Kreis, M.E., Kremer, B., Kroemer, H.K., Kröner-Herwig, B., Kroll, P., Külz, A.K., Kuhl, H., Kuipers, J.G., Laaser, M., Lamla, U., Lammert, F., Langer, M., Laß, M., Laukötter, M., Layer, P., Leffler, M., Lehnert, H., Lehrke, M., Lembcke, B., Lerch, M.M., Liebe, S., Lieber, A., Limmroth, V., Lochs, H., Loddenkemper, R., Löhr, J.-M., Löscher, T., Loh, A., Lorenz, H.-M., Lorenz, J., Lügering, N., Luster, M., Lux, G., Luzar, O., Maercker, A., Magdorf, K., Mallmann, P., Marth, T., May, K., Mayerle, J., Meinertz, T., Melichar, V., Merle, U., Meyer, H.J., Meyer, Th., Meyer-Lehnert, H., Meyer-Marcotty, A., Michels, H., Möbius, C., Möddel, G., Möhler, M., Mönnikes, H., Mössner, J., Mohaupt, M.G., Müller, S.C., Müller, S.A., Müller-Lissner, S., Müller-Quernheim, J., Muntau, A., Musholt, T.J., Nacimiento, W., Nattermann, J., Nelles, G., Neubrand, M., Neuhäuser, C., Neuhaus, P., Neumann, P.-A., Neundörfer, B., Nicolai, T., Niebling, W.-B., Niehues, T., Nilius, G., Nolde, J., Noth, J., Olschewski, H., Ostermeyer, J., Ott, C., Pahernik, S., Palmes, D., Pankratius, U., Parhofer, K., Paschke, R., Passlick, B., Pech, O., Pelster, F.W., Petersen, E.E., Petri, E., Pfaffenbach, B., Pfeifer, M., Pfeiffer, T., Pfister, H.W., Diplom-Gesundheitswirt, Pickel, J., Pilatz, A., Pirlich, M., Polykandriotis, E., Pontz, B., Possinger, K., Pohl-Koppe, A., Pohle, T., Prange, H., Prasse, A., Pruß, A., Rädle, J., Raile, K., Randerath, W., Rascher, W., Rauch, B., Raue, F., Raziorruh, B., Rech, J., Regierer, A.C., Reichel, C., Reindl, C., Reinhardt, D., Reißfelder, C., Rendl, J., Reuss-Borst, M., Rieckmann, P., Riedner, C., Rietschel, E., Rijcken, E., Rister, M., Rödder, K., Rogenhofer, S., Roos, F.C., Roos, R., Rosskopf, D., Rudnik-Schöneborn, S., Rudofsky<ce:sup loc='post">†</ce:sup>, G., Ruhnke, M., Ruß, M., Rust, C.F., Saborowski, F., Sailer, M., Salakdeh, M. Sedigh, Samtleben, Walter, Sandmann, W., Sauerbruch, T., Schaal, K.P., Schackert, G., Schäfer-Graf, U., Schäfers, M., Schalhorn, A., Schepp, W., Schetelig, J., Schifferdecker, M., Schipper, J., Schießl, A., Schlegel, U., Schliep, S., Schmid, A., Schmid, P., Schmidt, F., Schmied, B., Schmiegel, W., Schneider, A., Schneider, T., Schneider-Gold, C., Schnürch, H.-G., Schölmerich, J., Schönermarck, U., Schönhofer, B., Schönland, S., Scholz, H., Schopohl, J., Schott, G., Schrader, J., Schraml, A., Schrezenmeier, H., Schuchert, A., Schüßler, G., Schulze-Koops, H., Schuppan, D., Schuster, V., Schwab, S., Schwandner, O., Schwarz, C.H.M., Schwarz, T.F., Schweppe, K.W., Secknus, R., Segerer, S.E., Senninger, N., Serve, H., Seybold, U., Sezer, O., Siegmund, B., Siegmund, W., Siemon, G., Simmen, B.R., Simonetti, G., Sommer, C., Spengler, U., Sprott, H., Stabenow-Lohbauer, U., Stahl, M., Stalla, G., Stallmach, A., Stammschulte, T., Stebler, R., Stein, R., Steven, D., Sticherling, M., Stöhr, M., Strauch, U., Strauss, A., Strauß, H.-G., Stremmel, C., Stremmel, W., Strupp, M., Stüber, E., Stürz, H., Sure, U., Swoboda, B., Taube, C., Thiel, K., Thomssen, C., Thurau, K., Thöne, J., Thüroff, J., Tomiak, C., Toyka, K.V., Tröger, H., Trüeb, R.M., Tryba, M., Uhl, W., Ullerich, H., Unger, L., Vallböhmer, D., van Calker, D., Vloet, T., Voderholzer, U., Völkl, Thomas M.K., Vogel, T., Vogt, P., Wagenlehner, F.E.M., Wagner, A., Wagner, U., Wahn, V., Wallesch, C.W., Watzka, F., Weber, K., Weber, L., Weber, M.M., Wehrmann, T., Weidner, W., Weinke, T., Weiß, M., Weis-Müller, B.T., Weller, Michael, Wenz, F., Werdan, K., Wettstein, M., Wick, M., Wiegratz, I., Willems, S., Wilke, H., Wintergerst, U., Wirth, M., Wolkersdörfer, G.W., Wüster, C., Zabel, F., Zeidler, H., Zeitz, M., Zerres, K., Ziemer, G., Zierz, S., Zimmermann, T., and Zwerina, J.

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2015
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35. DEGRO 2004

Author

Wendt, Thomas G., primary, Gademann, G., additional, Pambor, C., additional, Grießbach, I., additional, von Specht, H., additional, Martin, T., additional, Baltas, D., additional, Kurek, R., additional, Röddiger, S., additional, Tunn, U. W., additional, Zamboglou, N., additional, Eich, H. T., additional, Staar, S., additional, Gossmann, A., additional, Hansemann, K., additional, Semrau, R., additional, Skripnitchenko, R., additional, Diehl, V., additional, Müller, R.-P., additional, Sehlen, S., additional, Willich, N., additional, Rühl, U., additional, Lukas, P., additional, Dühmke, E., additional, Engel, K., additional, Tabbert, E., additional, Bolck, M., additional, Knaack, S., additional, Annweiler, H., additional, Krempien, R., additional, Hoppe, H., additional, Harms, W., additional, Daeuber, S., additional, Schorr, O., additional, Treiber, M., additional, Debus, J., additional, Alber, M., additional, Paulsen, F., additional, Birkner, M., additional, Bakai, A., additional, Belka, C., additional, Budach, W., additional, Grosser, K.-H., additional, Kramer, R., additional, Kober, B., additional, Reinert, M., additional, Schneider, P., additional, Hertel, A., additional, Feldmann, H., additional, Csere, P., additional, Hoinkis, C., additional, Rothe, G., additional, Zahn, P., additional, Alheit, H., additional, Cavanaugh, S. X., additional, Kupelian, P., additional, Reddy, C., additional, Pollock, B., additional, Fuss, M., additional, Roeddiger, S., additional, Dannenberg, T., additional, Rogge, B., additional, Drechsler, D., additional, Herrmann, T., additional, Alberti, W., additional, Schwarz, R., additional, Graefen, M., additional, Krüll, A., additional, Rudat, V., additional, Huland, H., additional, Fehr, C., additional, Baum, C., additional, Glocker, S., additional, Nüsslin, F., additional, Heil, T., additional, Lemnitzer, H., additional, Knips, M., additional, Baumgart, O., additional, Thiem, W., additional, Kloetzer, K.-H., additional, Hoffmann, L., additional, Neu, B., additional, Hültenschmidt, B., additional, Sautter-Bihl, M.-L., additional, Micke, O., additional, Seegenschmiedt, M. H., additional, Köppen, D., additional, Klautke, G., additional, Fietkau, R., additional, Schultze, J., additional, Schlichting, G., additional, Koltze, H., additional, Kimmig, B., additional, Glatzel, M., additional, Fröhlich, D., additional, Bäsecke, S., additional, Krauß, A., additional, Strauß, D., additional, Buth, K.-J., additional, Böhme, R., additional, Oehler, W., additional, Bottke, D., additional, Keilholz, U., additional, Heufelder, K., additional, Wiegel, T., additional, Hinkelbein, W., additional, Rödel, C., additional, Papadopoulos, T., additional, Munnes, M., additional, Wirtz, R., additional, Sauer, R., additional, Rödel, F., additional, Lubgan, D., additional, Distel, L., additional, Grabenbauer, G. G., additional, Sak, A., additional, Stüben, G., additional, Pöttgen, C., additional, Grehl, S., additional, Stuschke, M., additional, Müller, K., additional, Pfaffendorf, C., additional, Mayerhofer, A., additional, Köhn, F. M., additional, Ring, J., additional, van Beuningen, D., additional, Meineke, V., additional, Neubauer, S., additional, Keller, U., additional, Wittlinger, M., additional, Riesenbeck, D., additional, Greve, B., additional, Exeler, R., additional, Ibrahim, M., additional, Liebscher, C., additional, Severin, E., additional, Ott, O., additional, Pötter, R., additional, Hammer, J., additional, Hildebrandt, G., additional, Beckmann, M. W., additional, Strnad, V., additional, Fehlauer, F., additional, Tribius, S., additional, Bajrovic, A., additional, Höller, U., additional, Rades, D., additional, Warszawski, A., additional, Baumann, R., additional, Madry-Gevecke, B., additional, Karstens, J. H., additional, Grehn, C., additional, Hensley, F., additional, Berns, C., additional, Wannenmacher, M., additional, Semrau, S., additional, Reimer, T., additional, Gerber, B., additional, Ketterer, P., additional, Koepcke, E., additional, Hänsgen, G., additional, Strauß, H. G., additional, Dunst, J., additional, Füller, J., additional, Kalb, S., additional, Wendt, T., additional, Weitmann, H. D., additional, Waldhäusl, C., additional, Knocke, T.-H., additional, Lamprecht, U., additional, Classen, J., additional, Kaulich, T. W., additional, Aydeniz, B., additional, Bamberg, M., additional, Wiezorek, T., additional, Banz, N., additional, Salz, H., additional, Scheithauer, M., additional, Schwedas, M., additional, Lutterbach, J., additional, Bartelt, S., additional, Frommhold, H., additional, Lambert, J., additional, Hornung, D., additional, Swiderski, S., additional, Walke, M., additional, Siefert, A., additional, Pöllinger, B., additional, Krimmel, K., additional, Schaffer, M., additional, Koelbl, O., additional, Bratengeier, K., additional, Vordermark, D., additional, Flentje, M., additional, Hero, B., additional, Berthold, F., additional, Combs, S. E., additional, Gutwein, S., additional, Schulz-Ertner, D., additional, van Kampen, M., additional, Thilmann, C., additional, Kocher, M., additional, Kunze, S., additional, Schild, S., additional, Ikezaki, K., additional, Müller, B., additional, Sieber, R., additional, Weiß, C., additional, Wolf, I., additional, Wenz, F., additional, Weber, K.-J., additional, Schäfer, J., additional, Engling, A., additional, Laufs, S., additional, Veldwijk, M. R., additional, Milanovic, D., additional, Fleckenstein, K., additional, Zeller, W., additional, Fruehauf, S., additional, Herskind, C., additional, Weinmann, M., additional, Jendrossek, V., additional, Rübe, C., additional, Appold, S., additional, Kusche, S., additional, Hölscher, T., additional, Brüchner, K., additional, Geyer, P., additional, Baumann, M., additional, Kumpf, R., additional, Zimmermann, F., additional, Schill, S., additional, Geinitz, H., additional, Nieder, C., additional, Jeremic, B., additional, Molls, M., additional, Liesenfeld, S., additional, Petrat, H., additional, Hesselmann, S., additional, Schäfer, U., additional, Bruns, F., additional, Horst, E., additional, Wilkowski, R., additional, Assmann, G., additional, Nolte, A., additional, Diebold, J., additional, Löhrs, U., additional, Fritz, P., additional, Hans-Jürgen, K., additional, Mühlnickel, W., additional, Bach, P., additional, Wahlers, B., additional, Kraus, H.-J., additional, Wulf, J., additional, Hädinger, U., additional, Baier, K., additional, Krieger, T., additional, Müller, G., additional, Hof, H., additional, Herfarth, K., additional, Brunner, T., additional, Hahn, S. M., additional, Schreiber, F. S., additional, Rustgi, A. K., additional, McKenna, W. G., additional, Bernhard, E. J., additional, Guckenberger, M., additional, Meyer, K., additional, Willner, J., additional, Schmidt, M., additional, Kolb, M., additional, Li, M., additional, Gong, P., additional, Abdollahi, A., additional, Trinh, T., additional, Huber, P. E., additional, Christiansen, H., additional, Saile, B., additional, Neubauer-Saile, K., additional, Tippelt, S., additional, Rave-Fränk, M., additional, Hermann, R. M., additional, Dudas, J., additional, Hess, C. F., additional, Schmidberger, H., additional, Ramadori, G., additional, Andratschke, N., additional, Price, R., additional, Ang, K.-K., additional, Schwarz, S., additional, Kulka, U., additional, Busch, M., additional, Schlenger, L., additional, Bohsung, J., additional, Eichwurzel, I., additional, Matnjani, G., additional, Sandrock, D., additional, Richter, M., additional, Wurm, R., additional, Budach, V., additional, Feussner, A., additional, Gellermann, J., additional, Jordan, A., additional, Scholz, R., additional, Gneveckow, U., additional, Maier-Hauff, K., additional, Ullrich, R., additional, Wust, P., additional, Felix, R., additional, Waldöfner, N., additional, Seebass, M., additional, Ochel, H.-J., additional, Dani, A., additional, Varkonyi, A., additional, Osvath, M., additional, Szasz, A., additional, Messer, P. M., additional, Blumstein, N. M., additional, Gottfried, H.-W., additional, Schneider, E., additional, Reske, S. N., additional, Röttinger, E. M., additional, Grosu, A.-L., additional, Franz, M., additional, Stärk, S., additional, Weber, W., additional, Heintz, M., additional, Indenkämpen, F., additional, Beyer, T., additional, Lübcke, W., additional, Levegrün, S., additional, Hayen, J., additional, Czech, N., additional, Mbarek, B., additional, Köster, R., additional, Thurmann, H., additional, Todorovic, M., additional, Schuchert, A., additional, Meinertz, T., additional, Münzel, T., additional, Grundtke, H., additional, Hornig, B., additional, Hehr, T., additional, Dilcher, C., additional, Chan, R. C., additional, Mintz, G. S., additional, Kotani, J.-I., additional, Shah, V. M., additional, Canos, D. A., additional, Weissman, N. J., additional, Waksman, R., additional, Wolfram, R., additional, Bürger, B., additional, Schrappe, M., additional, Timmermann, B., additional, Lomax, A., additional, Goitein, G., additional, Schuck, A., additional, Mattke, A., additional, Int-Veen, C., additional, Brecht, I., additional, Bernhard, S., additional, Treuner, J., additional, Koscielniak, E., additional, Heinze, F., additional, Kuhlen, M., additional, von Schorlemer, I., additional, Ahrens, S., additional, Hunold, A., additional, Könemann, S., additional, Winkelmann, W., additional, Jürgens, H., additional, Gerstein, J., additional, Polivka, B., additional, Sykora, K.-W., additional, Bremer, M., additional, Thamm, R., additional, Höpfner, C., additional, Gumprecht, H., additional, Jäger, R., additional, Leonardi, M. A., additional, Frank, A. M., additional, Trappe, A. E., additional, Lumenta, C. B., additional, Östreicher, E., additional, Pinsker, K., additional, Müller, A., additional, Fauser, C., additional, Arnold, W., additional, Henzel, M., additional, Groß, M. W., additional, Engenhart-Cabillic, R., additional, Schüller, P., additional, Palkovic, S., additional, Schröder, J., additional, Wassmann, H., additional, Block, A., additional, Bauer, R., additional, Keffel, F.-W., additional, Theophil, B., additional, Wisser, L., additional, Rogger, M., additional, Niewald, M., additional, van Lengen, V., additional, Mathias, K., additional, Welzel, G., additional, Bohrer, M., additional, Steinvorth, S., additional, Schleußner, C., additional, Leppert, K., additional, Röhrig, B., additional, Strauß, B., additional, van Oorschot, B., additional, Köhler, N., additional, Anselm, R., additional, Winzer, A., additional, Schneider, T., additional, Koch, U., additional, Schönekaes, K., additional, Mücke, R., additional, Büntzel, J., additional, Kisters, K., additional, Scholz, C., additional, Keller, M., additional, Winkler, C., additional, Prause, N., additional, Busch, R., additional, Roth, S., additional, Haas, I., additional, Willers, R., additional, Schultze-Mosgau, S., additional, Wiltfang, J., additional, Kessler, P., additional, Neukam, F. W., additional, Röper, B., additional, Nüse, N., additional, Auer, F., additional, Melzner, W., additional, Geiger, M., additional, Lotter, M., additional, Kuhnt, T., additional, Müller, A. C., additional, Jirsak, N., additional, Gernhardt, C., additional, Schaller, H.-G., additional, Al-Nawas, B., additional, Klein, M. O., additional, Ludwig, C., additional, Körholz, J., additional, Grötz, K. A., additional, Huppers, K., additional, Kunkel, M., additional, Olschewski, T., additional, Bajor, K., additional, Lang, B., additional, Lang, E., additional, Kraus-Tiefenbacher, U., additional, Hofheinz, R., additional, von Gerstenberg-Helldorf, B., additional, Willeke, F., additional, Hochhaus, A., additional, Roebel, M., additional, Oertel, S., additional, Riedl, S., additional, Buechler, M., additional, Foitzik, T., additional, Ludwig, K., additional, Klar, E., additional, Meyer, A., additional, Meier zu Eissen, J., additional, Schwab, D., additional, Meyer, T., additional, Höcht, S., additional, Siegmann, A., additional, Sieker, F., additional, Pigorsch, S., additional, Milicic, B., additional, Acimovic, L., additional, Milisavljevic, S., additional, Radosavljevic-Asic, G., additional, Presselt, N., additional, Baum, R. P., additional, Treutler, D., additional, Bonnet, R., additional, Schmücking, M., additional, Sammour, D., additional, Fink, T., additional, Ficker, J., additional, Pradier, O., additional, Lederer, K., additional, Weiss, E., additional, Hille, A., additional, Welz, S., additional, Sepe, S., additional, Friedel, G., additional, Spengler, W., additional, Susanne, E., additional, Kölbl, O., additional, Hoffmann, W., additional, Wörmann, B., additional, Günther, A., additional, Becker-Schiebe, M., additional, Güttler, J., additional, Schul, C., additional, Nitsche, M., additional, Körner, M. K., additional, Oppenkowski, R., additional, Guntrum, F., additional, Malaimare, L., additional, Raub, M., additional, Schöfl, C., additional, Averbeck, T., additional, Hacker, I., additional, Blank, H., additional, Böhme, C., additional, Imhoff, D., additional, Eberlein, K., additional, Weidauer, S., additional, Böttcher, H. D., additional, Edler, L., additional, Tatagiba, M., additional, Molina, H., additional, Ostertag, C., additional, Milker-Zabel, S., additional, Zabel, A., additional, Schlegel, W., additional, Hartmann, A., additional, Wildfang, I., additional, Kleinert, G., additional, Hamm, K., additional, Reuschel, W., additional, Wehrmann, R., additional, Kneschaurek, P., additional, Münter, M. W., additional, Nikoghosyan, A., additional, Didinger, B., additional, Nill, S., additional, Rhein, B., additional, Küstner, D., additional, Schalldach, U., additional, Eßer, D., additional, Göbel, H., additional, Wördehoff, H., additional, Pachmann, S., additional, Hollenhorst, H., additional, Dederer, K., additional, Evers, C., additional, Lamprecht, J., additional, Dastbaz, A., additional, Schick, B., additional, Fleckenstein, J., additional, Plinkert, P. K., additional, Rübe, Chr., additional, Merz, T., additional, Sommer, B., additional, Mencl, A., additional, Ghilescu, V., additional, Astner, S., additional, Martin, A., additional, Momm, F., additional, Volegova-Neher, N. J., additional, Schulte-Mönting, J., additional, Guttenberger, R., additional, Buchali, A., additional, Blank, E., additional, Sidow, D., additional, Huhnt, W., additional, Gorbatov, T., additional, Heinecke, A., additional, Beckmann, G., additional, Bentia, A.-M., additional, Schmitz, H., additional, Spahn, U., additional, Heyl, V., additional, Prott, P.-J., additional, Galalae, R., additional, Schneider, R., additional, Voith, C., additional, Scheda, A., additional, Hermann, B., additional, Bauer, L., additional, Melchert, F., additional, Kröger, N., additional, Grüneisen, A., additional, Jänicke, F., additional, Zander, A., additional, Zuna, I., additional, Schlöcker, I., additional, Wagner, K., additional, John, E., additional, Dörk, T., additional, Lochhas, G., additional, Houf, M., additional, Lorenz, D., additional, Link, K.-H., additional, Prott, F.-J., additional, Thoma, M., additional, Schauer, R., additional, Heinemann, V., additional, Romano, M., additional, Reiner, M., additional, Quanz, A., additional, Oppitz, U., additional, Bahrehmand, R., additional, Tine, M., additional, Naszaly, A., additional, Patonay, P., additional, Mayer, Á., additional, Markert, K., additional, Mai, S.-K., additional, Lohr, F., additional, Dobler, B., additional, Pinkawa, M., additional, Fischedick, K., additional, Treusacher, P., additional, Cengiz, D., additional, Mager, R., additional, Borchers, H., additional, Jakse, G., additional, Eble, M. 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E., additional, Feyer, P., additional, Püttmann, S., additional, Siekmeyer, B., additional, Jung, H., additional, Gagel, B., additional, Militz, U., additional, Piroth, M., additional, Schmachtenberg, A., additional, Hoelscher, T., additional, Verfaillie, C., additional, Kaminski, B., additional, Lücke, E., additional, Mörtel, H., additional, Eyrich, W., additional, Fritsch, M., additional, Georgi, J.-C., additional, Plathow, C., additional, Zieher, H., additional, Kiessling, F., additional, Peschke, P., additional, Kauczor, H.-U., additional, Licher, J., additional, Schneider, O., additional, Henschler, R., additional, Seidel, C., additional, Kolkmeyer, A., additional, Nguyen, T. P., additional, Janke, K., additional, Michaelis, M., additional, Bischof, M., additional, Stoffregen, C., additional, Lipson, K., additional, Weber, K., additional, Ehemann, V., additional, Jürgen, D., additional, Achanta, P., additional, Thompson, K., additional, Martinez, J. L., additional, Körschgen, T., additional, Pakala, R., additional, Pinnow, E., additional, Hellinga, D., additional, O’Tio, F., additional, Katzer, A., additional, Kaffer, A., additional, Kuechler, A., additional, Steinkirchner, S., additional, Dettmar, N., additional, Cordes, N., additional, Frick, S., additional, Kappler, M., additional, Taubert, H., additional, Bartel, F., additional, Schmidt, H., additional, Bache, M., additional, Frühauf, S., additional, Wenk, T., additional, Litzenberger, K., additional, Erren, M., additional, van Valen, F., additional, Liu, L., additional, Yang, K., additional, Palm, J., additional, Püsken, M., additional, Behe, M., additional, Behr, T. M., additional, Marini, P., additional, Johne, A., additional, Claussen, U., additional, Liehr, T., additional, Steil, V., additional, Moustakis, C., additional, Griessbach, I., additional, Oettel, A., additional, Schaal, C., additional, Reinhold, M., additional, Strasssmann, G., additional, Braun, I., additional, Vacha, P., additional, Richter, D., additional, Osterham, T., additional, Wolf, P., additional, Guenther, G., additional, Miemietz, M., additional, Lazaridis, E. A., additional, Forthuber, B., additional, Sure, M., additional, Klein, J., additional, Saleske, H., additional, Riedel, T., additional, Hirnle, P., additional, Horstmann, G., additional, Schoepgens, H., additional, Van Eck, A., additional, Bundschuh, O., additional, Van Oosterhut, A., additional, Xydis, K., additional, Theodorou, K., additional, Kappas, C., additional, Zurheide, J., additional, Fridtjof, N., additional, Ganswindt, U., additional, Weidner, N., additional, Buchgeister, M., additional, Weigel, B., additional, Müller, S. B., additional, Glashörster, M., additional, Weining, C., additional, Hentschel, B., additional, Sauer, O. A., additional, Kleen, W., additional, Beck, J., additional, Lehmann, D., additional, Ley, S., additional, Fink, C., additional, Puderbach, M., additional, Hosch, W., additional, Schmähl, A., additional, Jung, K., additional, Stoßberg, A., additional, Rolf, E., additional, Damrau, M., additional, Oetzel, D., additional, Maurer, U., additional, Maurer, G., additional, Lang, K., additional, Zumbe, J., additional, Hahm, D., additional, Fees, H., additional, Robrandt, B., additional, Melcher, U., additional, Niemeyer, M., additional, Mondry, A., additional, Kanellopoulos-Niemeyer, V., additional, Karle, H., additional, Jacob-Heutmann, D., additional, Born, C., additional, Mohr, W., additional, Kutzner, J., additional, Thelen, M., additional, Schiebe, M., additional, Pinkert, U., additional, Piasswilm, L., additional, Pohl, F., additional, Garbe, S., additional, Wolf, K., additional, Nour, Y., additional, Barwig, P., additional, Trog, D., additional, Schäfer, C., additional, Herbst, M., additional, Dietl, B., additional, Cartes, M., additional, Schroeder, F., additional, Sigingan-Tek, G., additional, Feierabend, R., additional, Theden, S., additional, Schlieck, A., additional, Gotthardt, M., additional, Glowalla, U., additional, Kremp, S., additional, Hamid, O., additional, Riefenstahl, N., additional, Michaelis, B., additional, Schaal, G., additional, Liebermeister, E., additional, Niewöhner-Desbordes, U., additional, Kowalski, M., additional, Franz, N., additional, Stahl, W., additional, Baumbach, C., additional, Thale, J., additional, Wagner, W., additional, Justus, B., additional, Huston, A. L., additional, Seaborn, R., additional, Rai, P., additional, Rha, S.-W., additional, Sakas, G., additional, Wesarg, S., additional, Zogal, P., additional, Schwald, B., additional, Seibert, H., additional, Berndt-Skorka, R., additional, Seifert, G., additional, Schoenekaes, K., additional, Bilecen, C., additional, Ito, W., additional, Matschuck, G., additional, and Isik, D., additional

Published
2004
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40. Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants:a Prospective Lynch Syndrome Database report

Author

Einar Andreas Rødland, Joan B. Vida, Heike Görgens, Eivind Hovig, Kirsi Pylvänäinen, Monika Morak, Wouter H. de Vos tot Nederveen Cappel, Lone Sunde, Mark A. Jenkins, Lucio Bertario, Patricia Esperon, Reinhard Büttner, Finlay A. Macrae, Inge Bernstein, Marc S. Greenblatt, Wolff Schmiegel, Giulia Martina Cavestro, Maria Grazia Tibiletti, Silke Redler, Zohreh Ketabi, Karl Heinimann, Fiona Lalloo, Huw Thomas, Christina Therkildsen, Deepak Vangala, Magnus von Knebel Doeberitz, Matilde Navarro, Erik Rokkones, Douglas Tjandra, D. G. Evans, Marta Pineda, Marian J.E. Mourits, Lior H. Katz, Bernardo Bonanni, Pablo Kalfayan, Stephen N. Thibodeau, Loic Le Marchand, Revital Kariv, Maartje Nielsen, Emma J Crosbie, Oliver G. Denton, Stefanie Holzapfel, Guy Rosner, Mev Dominguez-Valentin, John Burn, Verena Steinke-Lange, Carlos A. Vaccaro, Gabriela Möslein, Elke Holinski-Feder, Gabriel Capellá, Johanna Tecklenburg, Karin Wadt, Kate Green, Christoph Engel, Miriam Mints, Anna Lepistö, Tamara Alejandra Piñero, Jukka-Pekka Mecklin, John L. Hopper, Robert Hüneburg, Markus Loeffler, Florencia Neffa, Toni T. Seppälä, Claudia Perne, Polly A. Newcomb, Karin Alvarez, Adriana Della Valle, Julian R. Sampson, Sanne W. ten Broeke, Francisco Lopez-Koestner, John-Paul Plazzer, James Hill, Hans Georg Strauß, Ingrid Winship, Nathan Gluck, Aung Ko Win, Jane C. Figueiredo, Jürgen Weitz, Hans F. A. Vasen, Rolf H. Sijmons, Walter Hernán Pavicic, Stefan Aretz, Steven Gallinger, Noralane M. Lindor, Pål Møller, Laura Renkonen-Sinisalo, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Targeted Gynaecologic Oncology (TARGON), Seppala, T. T., Dominguez-Valentin, M., Crosbie, E. J., Engel, C., Aretz, S., Macrae, F., Winship, I., Capella, G., Thomas, H., Hovig, E., Nielsen, M., Sijmons, R. H., Bertario, L., Bonanni, B., Tibiletti, M. G., Cavestro, G. M., Mints, M., Gluck, N., Katz, L., Heinimann, K., Vaccaro, C. A., Green, K., Lalloo, F., Hill, J., Schmiegel, W., Vangala, D., Perne, C., Strauss, H. -G., Tecklenburg, J., Holinski-Feder, E., Steinke-Lange, V., Mecklin, J. -P., Plazzer, J. -P., Pineda, M., Navarro, M., Vida, J. B., Kariv, R., Rosner, G., Pinero, T. A., Pavicic, W., Kalfayan, P., ten Broeke, S. W., Jenkins, M. A., Sunde, L., Bernstein, I., Burn, J., Greenblatt, M., de Vos tot Nederveen Cappel, W. H., Della Valle, A., Lopez-Koestner, F., Alvarez, K., Buttner, R., Gorgens, H., Morak, M., Holzapfel, S., Huneburg, R., von Knebel Doeberitz, M., Loeffler, M., Redler, S., Weitz, J., Pylvanainen, K., Renkonen-Sinisalo, L., Lepisto, A., Hopper, J. L., Win, A. K., Lindor, N. M., Gallinger, S., Le Marchand, L., Newcomb, P. A., Figueiredo, J. C., Thibodeau, S. N., Therkildsen, C., Wadt, K. A. W., Mourits, M. J. E., Ketabi, Z., Denton, O. G., Rodland, E. A., Vasen, H., Neffa, F., Esperon, P., Tjandra, D., Moslein, G., Rokkones, E., Sampson, J. R., Evans, D. G., Moller, P., Genome-Scale Biology (GSB) Research Program, HUS Abdominal Center, Clinicum, II kirurgian klinikka, Department of Surgery, and Doctoral Programme in Clinical Research

Subjects
0301 basic medicine, Cancer Research, Oophorectomy, Databases, Factual, Colorectal cancer, SURGERY, medicine.medical_treatment, Càncer d'ovari, computer.software_genre, DNA Mismatch Repair, 0302 clinical medicine, Endometrial cancer, munasarjasyöpä, Medicine, Prospective Studies, Colectomy, Salpingo-oophorectomy/methods, Database, Manchester Cancer Research Centre, COLON-CANCER, MLH1, WOMEN, Middle Aged, Prognosis, Lynch syndrome, 3. Good health, kohdunrungon syöpä, Oncology, COLECTOMY, 030220 oncology & carcinogenesis, Female, Biomarkers, Tumor/genetics, Adult, Heterozygote, Genital Neoplasms, Female, Salpingo-oophorectomy, Hysterectomy, 03 medical and health sciences, Genital Neoplasms, Female/prevention & control, Ovarian cancer, Colorectal Neoplasms, Hereditary Nonpolyposis/genetics, Biomarkers, Tumor, Mortalitat, Humans, Hysterectomy/methods, Mortality, Lynchin oireyhtymä, Risk-reducing surgery, Aged, business.industry, ResearchInstitutes_Networks_Beacons/mcrc, Cancer, MSH6, 3126 Surgery, anesthesiology, intensive care, radiology, medicine.disease, Colorectal Neoplasms, Hereditary Nonpolyposis, MSH2, 030104 developmental biology, Cross-Sectional Studies, PMS2, Càncer d'endometri, Mutation, kohdunpoisto, business, computer, Follow-Up Studies
Abstract

Purpose: This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants.Methods: The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30-69 years.Results: Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds of procedures before 50 years of age were combined hysterectomy and BSO, and 81% of all procedures included BSO. Risk-reducing hysterectomy was performed before age 50 years in 28%, 25%, 15%, and 9%, and BSO in 26%, 25%, 14% and 13% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 carriers, respectively. Before 50 years of age, 107 of 188 (57%) BSO and 126 of 204 (62%) hysterectomies were performed in women without any prior cancer, and only 5% (20/392) were performed simultaneously with colorectal cancer (CRC) surgery.Conclusion: Uptake of RRS before 50 years of age was low, and RRS was rarely undertaken in association with surgical treatment of CRC. Uptake of RRS aligned poorly with gene-and age-associated risk estimates for endometrial or ovarian cancer that were published recently from PLSD and did not correspond well with current clinical guidelines. The reasons should be clarified. Decision-making on opting for or against RRS and its timing should be better aligned with predicted risk and mortality for endometrial and ovarian cancer in Lynch syn-drome to improve outcomes. (C) 2021 The Author(s). Published by Elsevier Ltd.

Published
2021

41. Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report

Author

Eivind Hovig, Bernardo Bonanni, Monika Morak, Mark A. Jenkins, Patricia Esperon, Toni T. Seppälä, Lone Sunde, Pablo Kalfayan, Gabriel Capellá, Inge Bernstein, Matilde Navarro, Marc S. Greenblatt, John Burn, Zohreh Ketabi, Johanna Tecklenburg, Francisco Lopez-Koestner, Miriam Mints, Heike Görgens, Neil A J Ryan, Kate Green, Annika Auranen, Douglas Tjandra, Robert W. Haile, Marta Pineda, Tamara Alejandra Piñero, Stefan Aretz, Robert Hüneburg, Verena Steinke-Lange, Markus Loeffler, Christina Therkildsen, John L. Hopper, Deepak Vangala, Huw Thomas, Reinhard Büttner, James Hill, Einar Andreas Rødland, Revital Kariv, Maria Grazia Tibiletti, Sigve Nakken, Stefanie Holzapfel, D. Gareth Evans, Oliver G. Denton, Julian R. Sampson, Henrik Okkels, Joan Vidal, Loic Le Marchand, Hans Georg Strauß, Gabriela Möslein, Claudia Perne, Ingrid Winship, Nathan Gluck, Jane C. Figueiredo, Mev Dominguez-Valentin, Wolff Schmiegel, Karl Heinimann, Kirsi Pylvänäinen, Karin Alvarez, Maartje Nielsen, Wouter H. de Vos tot Nederveen Cappel, Fiona Lalloo, Aung Ko Win, Guy Rosner, Carlos A. Vaccaro, Polly A. Newcomb, Elke Holinski-Feder, John-Paul Plazzer, Lior H. Katz, Christoph Engel, Anna Lepistö, Jukka-Pekka Mecklin, Giulia Martina Cavestro, Adriana Della Valle, Finlay A. Macrae, Sanne W. ten Broeke, Florencia Neffa, Rolf H. Sijmons, María Laura Gonzalez, Nils Rahner, Jürgen Weitz, Hans F. A. Vasen, Stephen N. Thibodeau, Emma J Crosbie, Lucio Bertario, Steven Gallinger, Noralane M. Lindor, Pål Møller, Laura Renkonen-Sinisalo, Magnus von Knebel Doeberitz, Dominguez-Valentin, M., Crosbie, E. J., Engel, C., Aretz, S., Macrae, F., Winship, I., Capella, G., Thomas, H., Nakken, S., Hovig, E., Nielsen, M., Sijmons, R. H., Bertario, L., Bonanni, B., Tibiletti, M. G., Cavestro, G. M., Mints, M., Gluck, N., Katz, L., Heinimann, K., Vaccaro, C. A., Green, K., Lalloo, F., Hill, J., Schmiegel, W., Vangala, D., Perne, C., Strauss, H. -G., Tecklenburg, J., Holinski-Feder, E., Steinke-Lange, V., Mecklin, J. -P., Plazzer, J. -P., Pineda, M., Navarro, M., Vidal, J. B., Kariv, R., Rosner, G., Pinero, T. A., Gonzalez, M. L., Kalfayan, P., Ryan, N., ten Broeke, S. W., Jenkins, M. A., Sunde, L., Bernstein, I., Burn, J., Greenblatt, M., de Vos tot Nederveen Cappel, W. H., Della Valle, A., Lopez-Koestner, F., Alvarez, K., Buttner, R., Gorgens, H., Morak, M., Holzapfel, S., Huneburg, R., von Knebel Doeberitz, M., Loeffler, M., Rahner, N., Weitz, J., Pylvanainen, K., Renkonen-Sinisalo, L., Lepisto, A., Auranen, A., Hopper, J. L., Win, A. K., Haile, R. W., Lindor, N. M., Gallinger, S., Le Marchand, L., Newcomb, P. A., Figueiredo, J. C., Thibodeau, S. N., Therkildsen, C., Okkels, H., Ketabi, Z., Denton, O. G., Rodland, E. A., Vasen, H., Neffa, F., Esperon, P., Tjandra, D., Moslein, G., Sampson, J. R., Evans, D. G., Seppala, T. T., Moller, P., ATG - Applied Tumor Genomics, HUS Abdominal Center, II kirurgian klinikka, Department of Surgery, Clinicum, Helsinki University Hospital Area, and University of Helsinki

Subjects
0301 basic medicine, medicine.medical_treatment, DNA Mismatch Repair, Gynecologic surgery, 0302 clinical medicine, Malalties hereditàries, Prospective Studies, Prospective cohort study, Genetics (clinical), Mismatch Repair Endonuclease PMS2, Incidence (epidemiology), Middle Aged, 16. Peace & justice, Lynch syndrome, 3. Good health, 030220 oncology & carcinogenesis, Female, syöpätaudit, MutL Protein Homolog 1, Genetic diseases, Heterozygote, medicine.medical_specialty, Salpingo-oophorectomy, Cirurgia ginecològica, Hysterectomy, Article, 03 medical and health sciences, Càncer colorectal, CAPP2, medicine, Humans, Lynchin oireyhtymä, Gynecology, perinnölliset taudit, HEREDITARY COLORECTAL-CANCER, business.industry, Endometrial cancer, Cancer, medicine.disease, Colorectal Neoplasms, Hereditary Nonpolyposis, Colorectal cancer, ASPIRIN, 030104 developmental biology, Clinical research, 3121 General medicine, internal medicine and other clinical medicine, kohdunpoisto, 3111 Biomedicine, Ovarian cancer, business
Abstract

Purpose To determine impact of risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) on gynecological cancer incidence and death in heterozygotes of pathogenic MMR ( path_MMR ) variants. Methods The Prospective Lynch Syndrome Database was used to investigate the effects of gynecological risk-reducing surgery (RRS) at different ages. Results Risk-reducing hysterectomy at 25 years of age prevents endometrial cancer before 50 years in 15%, 18%, 13%, and 0% of path_MLH1 , path_MSH2 , path_MSH6 , and path_PMS2 heterozygotes and death in 2%, 2%, 1%, and 0%, respectively. Risk-reducing BSO at 25 years of age prevents ovarian cancer before 50 years in 6%, 11%, 2%, and 0% and death in 1%, 2%, 0%, and 0%, respectively. Risk-reducing hysterectomy at 40 years prevents endometrial cancer by 50 years in 13%, 16%, 11%, and 0% and death in 1%, 2%, 1%, and 0%, respectively. BSO at 40 years prevents ovarian cancer before 50 years in 4%, 8%, 0%, and 0%, and death in 1%, 1%, 0%, and 0%, respectively. Conclusion Little benefit is gained by performing RRS before 40 years of age and premenopausal BSO in path_MSH6 and path_PMS2 heterozygotes has no measurable benefit for mortality. These findings may aid decision making for women with LS who are considering RRS.

Published
2021

43. Phase II trial of docetaxel and carboplatin in recurrent platinum-sensitive ovarian, peritoneal and tubal cancer.

Author

Strauss HG, Henze A, Teichmann A, Karbe I, Baumgart A, Thomssen C, and Koelbl H

Subjects
Adult, Aged, Antineoplastic Combined Chemotherapy Protocols adverse effects, Carboplatin administration & dosage, Carboplatin adverse effects, Disease-Free Survival, Docetaxel, Drug Resistance, Neoplasm, Female, Humans, Middle Aged, Taxoids administration & dosage, Taxoids adverse effects, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Fallopian Tube Neoplasms drug therapy, Neoplasm Recurrence, Local drug therapy, Ovarian Neoplasms drug therapy, Peritoneal Neoplasms drug therapy
Abstract

Objective: Docetaxel and carboplatin are active in relapsed ovarian, peritoneal and tubal cancer. Recently, two prospective-randomized trials showed an advantage of carboplatin combination regimen with paclitaxel or gemcitabine over carboplatinum alone in platinum-sensitive cases. The question on the most effective combination with the best tolerable side effects still needs to be answered., Methods: Eligible patients had recurrent ovarian, peritoneal or tubal cancer (platinum-free interval >6 months), performance status 0-2 and normal bone marrow, renal and hepatic function. 25 patients (age 18-75 years) were enrolled into this phase II trial. Patients with debulking operation of recurrence were excluded from this study. Docetaxel 75 mg/m(2) via 30-min infusion was given on day 1 followed by carboplatin (area under curve [AUC] 5) on day 1. The administration was repeated every 3 weeks over 6 courses. Primary endpoint of this trial was the response rate; secondary endpoints were progression-free survival, overall survival and toxicity., Results: In the intent-to-treat population, there were 16 (64.0%) complete and 2 (8.0%) partial responses resulting in an overall response rate of 72.0%. Three patients (12.0%) showed a stable disease and other 2 patients (8.0%) a progression of cancer. Two patients (8.0%) were not evaluable for response. Neutropenia was the most frequent G3/G4 hematologic toxicity in 15/25 patients (60.0%); but no neutropenic fever occurred in this trial. Diarrhea G3 was the most frequent G3/G4 non-hematologic toxicity in only 3/25 patients (12.0%). Dose-limiting toxicities were hypersensitivity reaction in one and depressive mood alteration requiring therapy in another case., Conclusion: Carboplatin in combination with docetaxel is highly active and well tolerated in patients with recurrent platinum-sensitive ovarian, peritoneal and tubal cancer. Prospective-randomized trials comparing this with other carboplatin therapeutic doublets in patients with recurrent ovarian cancer are a possible option for the future to answer the question on the best combination regimen.

Published
2007
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44. [Not Available].

Author

Wendt TG, Gademann G, Pambor C, Grießbach I, von Specht H, Martin T, Baltas D, Kurek R, Röddiger S, Tunn UW, Zamboglou N, Eich HT, Staar S, Gossmann A, Hansemann K, Semrau R, Skripnitchenko R, Diehl V, Müller RP, Sehlen S, Willich N, Rühl U, Lukas P, Dühmke E, Engel K, Tabbert E, Bolck M, Knaack S, Annweiler H, Krempien R, Hoppe H, Harms W, Daeuber S, Schorr O, Treiber M, Debus J, Alber M, Paulsen F, Birkner M, Bakai A, Belka C, Budach W, Grosser KH, Kramer R, Kober B, Reinert M, Schneider P, Hertel A, Feldmann H, Csere P, Hoinkis C, Rothe G, Zahn P, Alheit H, Cavanaugh SX, Kupelian P, Reddy C, Pollock B, Fuss M, Roeddiger S, Dannenberg T, Rogge B, Drechsler D, Herrmann T, Alberti W, Schwarz R, Graefen M, Krüll A, Rudat V, Huland H, Fehr C, Baum C, Glocker S, Nüsslin F, Heil T, Lemnitzer H, Knips M, Baumgart O, Thiem W, Kloetzer KH, Hoffmann L, Neu B, Hültenschmidt B, Sautter-Bihl ML, Micke O, Seegenschmiedt MH, Köppen D, Klautke G, Fietkau R, Schultze J, Schlichting G, Koltze H, Kimmig B, Glatzel M, Fröhlich D, Bäsecke S, Krauß A, Strauß D, Buth KJ, Böhme R, Oehler W, Bottke D, Keilholz U, Heufelder K, Wiegel T, Hinkelbein W, Rödel C, Papadopoulos T, Munnes M, Wirtz R, Sauer R, Rödel F, Lubgan D, Distel L, Grabenbauer GG, Sak A, Stüben G, Pöttgen C, Grehl S, Stuschke M, Müller K, Pfaffendorf C, Mayerhofer A, Köhn FM, Ring J, van Beuningen D, Meineke V, Neubauer S, Keller U, Wittlinger M, Riesenbeck D, Greve B, Exeler R, Ibrahim M, Liebscher C, Severin E, Ott O, Pötter R, Hammer J, Hildebrandt G, Beckmann MW, Strnad V, Fehlauer F, Tribius S, Bajrovic A, Höller U, Rades D, Warszawski A, Baumann R, Madry-Gevecke B, Karstens JH, Grehn C, Hensley F, Berns C, Wannenmacher M, Semrau S, Reimer T, Gerber B, Ketterer P, Koepcke E, Hänsgen G, Strauß HG, Dunst J, Füller J, Kalb S, Wendt T, Weitmann HD, Waldhäusl C, Knocke TH, Lamprecht U, Classen J, Kaulich TW, Aydeniz B, Bamberg M, Wiezorek T, Banz N, Salz H, Scheithauer M, Schwedas M, Lutterbach J, Bartelt S, Frommhold H, Lambert J, Hornung D, Swiderski S, Walke M, Siefert A, Pöllinger B, Krimmel K, Schaffer M, Koelbl O, Bratengeier K, Vordermark D, Flentje M, Hero B, Berthold F, Combs SE, Gutwein S, Schulz-Ertner D, van Kampen M, Thilmann C, Kocher M, Kunze S, Schild S, Ikezaki K, Müller B, Sieber R, Weiß C, Wolf I, Wenz F, Weber KJ, Schäfer J, Engling A, Laufs S, Veldwijk MR, Milanovic D, Fleckenstein K, Zeller W, Fruehauf S, Herskind C, Weinmann M, Jendrossek V, Rübe C, Appold S, Kusche S, Hölscher T, Brüchner K, Geyer P, Baumann M, Kumpf R, Zimmermann F, Schill S, Geinitz H, Nieder C, Jeremic B, Molls M, Liesenfeld S, Petrat H, Hesselmann S, Schäfer U, Bruns F, Horst E, Wilkowski R, Assmann G, Nolte A, Diebold J, Löhrs U, Fritz P, Hans-Jürgen K, Mühlnickel W, Bach P, Wahlers B, Kraus HJ, Wulf J, Hädinger U, Baier K, Krieger T, Müller G, Hof H, Herfarth K, Brunner T, Hahn SM, Schreiber FS, Rustgi AK, McKenna WG, Bernhard EJ, Guckenberger M, Meyer K, Willner J, Schmidt M, Kolb M, Li M, Gong P, Abdollahi A, Trinh T, Huber PE, Christiansen H, Saile B, Neubauer-Saile K, Tippelt S, Rave-Fränk M, Hermann RM, Dudas J, Hess CF, Schmidberger H, Ramadori G, Andratschke N, Price R, Ang KK, Schwarz S, Kulka U, Busch M, Schlenger L, Bohsung J, Eichwurzel I, Matnjani G, Sandrock D, Richter M, Wurm R, Budach V, Feussner A, Gellermann J, Jordan A, Scholz R, Gneveckow U, Maier-Hauff K, Ullrich R, Wust P, Felix R, Waldöfner N, Seebass M, Ochel HJ, Dani A, Varkonyi A, Osvath M, Szasz A, Messer PM, Blumstein NM, Gottfried HW, Schneider E, Reske SN, Röttinger EM, Grosu AL, Franz M, Stärk S, Weber W, Heintz M, Indenkämpen F, Beyer T, Lübcke W, Levegrün S, Hayen J, Czech N, Mbarek B, Köster R, Thurmann H, Todorovic M, Schuchert A, Meinertz T, Münzel T, Grundtke H, Hornig B, Hehr T, Dilcher C, Chan RC, Mintz GS, Kotani JI, Shah VM, Canos DA, Weissman NJ, Waksman R, Wolfram R, Bürger B, Schrappe M, Timmermann B, Lomax A, Goitein G, Schuck A, Mattke A, Int-Veen C, Brecht I, Bernhard S, Treuner J, Koscielniak E, Heinze F, Kuhlen M, von Schorlemer I, Ahrens S, Hunold A, Könemann S, Winkelmann W, Jürgens H, Gerstein J, Polivka B, Sykora KW, Bremer M, Thamm R, Höpfner C, Gumprecht H, Jäger R, Leonardi MA, Frank AM, Trappe AE, Lumenta CB, Östreicher E, Pinsker K, Müller A, Fauser C, Arnold W, Henzel M, Groß MW, Engenhart-Cabillic R, Schüller P, Palkovic S, Schröder J, Wassmann H, Block A, Bauer R, Keffel FW, Theophil B, Wisser L, Rogger M, Niewald M, van Lengen V, Mathias K, Welzel G, Bohrer M, Steinvorth S, Schleußner C, Leppert K, Röhrig B, Strauß B, van Oorschot B, Köhler N, Anselm R, Winzer A, Schneider T, Koch U, Schönekaes K, Mücke R, Büntzel J, Kisters K, Scholz C, Keller M, Winkler C, Prause N, Busch R, Roth S, Haas I, Willers R, Schultze-Mosgau S, Wiltfang J, Kessler P, Neukam FW, Röper B, Nüse N, Auer F, Melzner W, Geiger M, Lotter M, Kuhnt T, Müller AC, Jirsak N, Gernhardt C, Schaller HG, Al-Nawas B, Klein MO, Ludwig C, Körholz J, Grötz KA, Huppers K, Kunkel M, Olschewski T, Bajor K, Lang B, Lang E, Kraus-Tiefenbacher U, Hofheinz R, von Gerstenberg-Helldorf B, Willeke F, Hochhaus A, Roebel M, Oertel S, Riedl S, Buechler M, Foitzik T, Ludwig K, Klar E, Meyer A, Meier Zu Eissen J, Schwab D, Meyer T, Höcht S, Siegmann A, Sieker F, Pigorsch S, Milicic B, Acimovic L, Milisavljevic S, Radosavljevic-Asic G, Presselt N, Baum RP, Treutler D, Bonnet R, Schmücking M, Sammour D, Fink T, Ficker J, Pradier O, Lederer K, Weiss E, Hille A, Welz S, Sepe S, Friedel G, Spengler W, Susanne E, Kölbl O, Hoffmann W, Wörmann B, Günther A, Becker-Schiebe M, Güttler J, Schul C, Nitsche M, Körner MK, Oppenkowski R, Guntrum F, Malaimare L, Raub M, Schöfl C, Averbeck T, Hacker I, Blank H, Böhme C, Imhoff D, Eberlein K, Weidauer S, Böttcher HD, Edler L, Tatagiba M, Molina H, Ostertag C, Milker-Zabel S, Zabel A, Schlegel W, Hartmann A, Wildfang I, Kleinert G, Hamm K, Reuschel W, Wehrmann R, Kneschaurek P, Münter MW, Nikoghosyan A, Didinger B, Nill S, Rhein B, Küstner D, Schalldach U, Eßer D, Göbel H, Wördehoff H, Pachmann S, Hollenhorst H, Dederer K, Evers C, Lamprecht J, Dastbaz A, Schick B, Fleckenstein J, Plinkert PK, Rübe C, Merz T, Sommer B, Mencl A, Ghilescu V, Astner S, Martin A, Momm F, Volegova-Neher NJ, Schulte-Mönting J, Guttenberger R, Buchali A, Blank E, Sidow D, Huhnt W, Gorbatov T, Heinecke A, Beckmann G, Bentia AM, Schmitz H, Spahn U, Heyl V, Prott PJ, Galalae R, Schneider R, Voith C, Scheda A, Hermann B, Bauer L, Melchert F, Kröger N, Grüneisen A, Jänicke F, Zander A, Zuna I, Schlöcker I, Wagner K, John E, Dörk T, Lochhas G, Houf M, Lorenz D, Link KH, Prott FJ, Thoma M, Schauer R, Heinemann V, Romano M, Reiner M, Quanz A, Oppitz U, Bahrehmand R, Tine M, Naszaly A, Patonay P, Mayer Á, Markert K, Mai SK, Lohr F, Dobler B, Pinkawa M, Fischedick K, Treusacher P, Cengiz D, Mager R, Borchers H, Jakse G, Eble MJ, Asadpour B, Krenkel B, Holy R, Kaplan Y, Block T, Czempiel H, Haverkamp U, Prümer B, Christian T, Benkel P, Weber C, Gruber S, Reimann P, Blumberg J, Krause K, Fischedick AR, Kaube K, Steckler K, Henzel B, Licht N, Loch T, Krystek A, Lilienthal A, Alfia H, Claßen J, Spillner P, Knutzen B, Souchon R, Schulz I, Grüschow K, Küchenmeister U, Vogel H, Wolff D, Ramm U, Licner J, Rudolf F, Moog J, Rahl CG, Mose S, Vorwerk H, Weiß E, Engert A, Seufert I, Schwab F, Dahlke J, Zabelina T, Krüger W, Kabisch H, Platz V, Wolf J, Pfistner B, Stieltjes B, Wilhelm T, Schmuecking M, Junker K, Treutier D, Schneider CP, Leonhardi J, Niesen A, Hoeffken K, Schmidt A, Mueller KM, Schmid I, Lehmann K, Blumstein CG, Kreienberg R, Freudenberg L, Kühl H, Stahl M, Elo B, Erichsen P, Stattaus H, Welzel T, Mende U, Heiland S, Salter BJ, Schmid R, Stratakis D, Huber RM, Haferanke J, Zöller N, Henke M, Lorenzen J, Grzyska B, Kuhlmey A, Adam G, Hamelmann V, Bölling T, Job H, Panke JE, Feyer P, Püttmann S, Siekmeyer B, Jung H, Gagel B, Militz U, Piroth M, Schmachtenberg A, Hoelscher T, Verfaillie C, Kaminski B, Lücke E, Mörtel H, Eyrich W, Fritsch M, Georgi JC, Plathow C, Zieher H, Kiessling F, Peschke P, Kauczor HU, Licher J, Schneider O, Henschler R, Seidel C, Kolkmeyer A, Nguyen TP, Janke K, Michaelis M, Bischof M, Stoffregen C, Lipson K, Weber K, Ehemann V, Jürgen D, Achanta P, Thompson K, Martinez JL, Körschgen T, Pakala R, Pinnow E, Hellinga D, O'Tio F, Katzer A, Kaffer A, Kuechler A, Steinkirchner S, Dettmar N, Cordes N, Frick S, Kappler M, Taubert H, Bartel F, Schmidt H, Bache M, Frühauf S, Wenk T, Litzenberger K, Erren M, van Valen F, Liu L, Yang K, Palm J, Püsken M, Behe M, Behr TM, Marini P, Johne A, Claussen U, Liehr T, Steil V, Moustakis C, Griessbach I, Oettel A, Schaal C, Reinhold M, Strasssmann G, Braun I, Vacha P, Richter D, Osterham T, Wolf P, Guenther G, Miemietz M, Lazaridis EA, Forthuber B, Sure M, Klein J, Saleske H, Riedel T, Hirnle P, Horstmann G, Schoepgens H, Van Eck A, Bundschuh O, Van Oosterhut A, Xydis K, Theodorou K, Kappas C, Zurheide J, Fridtjof N, Ganswindt U, Weidner N, Buchgeister M, Weigel B, Müller SB, Glashörster M, Weining C, Hentschel B, Sauer OA, Kleen W, Beck J, Lehmann D, Ley S, Fink C, Puderbach M, Hosch W, Schmähl A, Jung K, Stoßberg A, Rolf E, Damrau M, Oetzel D, Maurer U, Maurer G, Lang K, Zumbe J, Hahm D, Fees H, Robrandt B, Melcher U, Niemeyer M, Mondry A, Kanellopoulos-Niemeyer V, Karle H, Jacob-Heutmann D, Born C, Mohr W, Kutzner J, Thelen M, Schiebe M, Pinkert U, Piasswilm L, Pohl F, Garbe S, Wolf K, Nour Y, Barwig P, Trog D, Schäfer C, Herbst M, Dietl B, Cartes M, Schroeder F, Sigingan-Tek G, Feierabend R, Theden S, Schlieck A, Gotthardt M, Glowalla U, Kremp S, Hamid O, Riefenstahl N, Michaelis B, Schaal G, Liebermeister E, Niewöhner-Desbordes U, Kowalski M, Franz N, Stahl W, Baumbach C, Thale J, Wagner W, Justus B, Huston AL, Seaborn R, Rai P, Rha SW, Sakas G, Wesarg S, Zogal P, Schwald B, Seibert H, Berndt-Skorka R, Seifert G, Schoenekaes K, Bilecen C, Ito W, Matschuck G, and Isik D

Published
2004
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45. Ectopic lobular breast cancer of the vulva.

Author

Neumann I, Strauss HG, Buchmann J, and Koelbl H

Subjects
Choristoma, Female, Humans, Lymph Node Excision, Middle Aged, Neoplasm Invasiveness, Neoplasm Metastasis, Ultrasonography, Vulvar Neoplasms diagnostic imaging, Vulvar Neoplasms pathology, Vulvar Neoplasms surgery, Breast Neoplasms pathology, Vulvar Neoplasms secondary
Abstract

Background: Primary breast cancer of the vulvar region is a rare tumor entity. Only 12 cases have been published so far in the literature., Patient and Methods: We report on a case of a 60-year old woman with an invasive lobular breast cancer localized to the vulva. The woman with elevated CA 15-3 and CEA markers underwent local wide excision of the tumor and bilateral inguinal lymphonodectomy, adjuvant anthracycline containing chemotherapy and locoregional irradiation including both inguinal regions and subsequent endocrine therapy with tamoxifen., Results: The resected specimen showed an estrogen receptor-positive diffuse infiltrating lobular breast cancer of the vulva with metastases in both groins. Original tissue of the breast adjacent to the malignant vulvar transformation was lacking. Imaging of the breast was lacking any pathology. Our patient has been followed up for 20 months without any signs of progressive disease., Conclusion: Due to the rare occurrence, we are not able to give general guidelines for the treatment of ectopic breast cancer. However, adjustment of treatment to the therapeutic recommendations for orthotopic breast cancer seems reasonable and effective.

Published
2000

46. Significance of endovaginal ultrasonography in assessing tamoxifen-associated changes of the endometrium. A prospective study.

Author

Strauss HG, Wolters M, Methfessel G, Buchmann J, and Koelbl H

Subjects
Aged, Aged, 80 and over, Antineoplastic Agents, Hormonal therapeutic use, Breast Neoplasms drug therapy, Endometrium diagnostic imaging, Endometrium pathology, False Positive Reactions, Female, Humans, Middle Aged, Prospective Studies, Tamoxifen therapeutic use, Ultrasonography, Antineoplastic Agents, Hormonal adverse effects, Endometrium drug effects, Tamoxifen adverse effects, Vagina diagnostic imaging
Abstract

Background: A prospective study was conducted investigating the value of endovaginal ultrasound in the assessment of tamoxifen-associated changes of the endometrium in patients with breast cancer., Methods: Seventy postmenopausal patients with breast cancer treated with anti-estrogens for at least 6 months were entered. Those with bleeding disorders and/or an endometrial thickness of > or =10 mm found on ultrasonography underwent hysteroscopy and dilatation and curettage (D&C) for further histological evaluation. In 22 patients, positive ultrasound findings could be compared with histopathology., Results: 82% of the 22 patients with positive sonographic findings had a glandular-cystic hyperplasia or a glandular-cystic polyp. No adenomatous hyperplasia or endometrial cancer was observed in our series., Conclusion: Vaginal ultrasound represents a useful diagnostic tool to detect tamoxifen-associated changes of the endometrium. A threshold of 10 mm endometrial thickness appears suitable to identify endometrial abnormalities while reducing the rate of false-positive findings to an acceptable level. However, the role of vaginal ultrasound in screening for endometrial cancer or premalignant lesions remains uncertain.

Published
2000

47. [Preoperative axilla sonography in breast tumor suspected of malignancy--a diagnostic advantage?].

Author

Strauss HG, Lampe D, Methfessel G, and Buchmann J

Subjects
Adenocarcinoma diagnostic imaging, Adenocarcinoma pathology, Adult, Aged, Aged, 80 and over, Axilla, Breast Neoplasms pathology, Carcinoma, Ductal, Breast diagnostic imaging, Carcinoma, Ductal, Breast pathology, Carcinoma, Lobular diagnostic imaging, Carcinoma, Lobular pathology, Female, Humans, Lymph Nodes pathology, Lymphatic Metastasis, Middle Aged, Neoplasm Staging, Sensitivity and Specificity, Breast Neoplasms diagnostic imaging, Lymph Nodes diagnostic imaging, Ultrasonography, Mammary
Abstract

Purpose: To assess the value of preoperative axillary sonography possibly malignant for breast tumours., Method: We performed preoperative axillary sonography on 89 patients with suspicious breast tumours. In 78 cases, among which there were 74 invasive carcinomas, the surgery that followed included an axillary lymph node dissection and a comparison with the histology was possible., Results: The sonographic detection of axillary lymph node metastases has a sensitivity of 90% and a specificity of 91.7% in relation to all tumour stages and a sensitivity of 100% and specificity of 89.6% in relation to T1 tumours. In our analysis, therefore, it is vastly superior to a clinical examination of the axilla., Conclusion: Ultrasonography is an accurate imaging method for the diagnosis of axillary lymph node metastases. Broadening this analysis to include more patients will validate this conclusion. The results of our preliminary study suggest that this diagnostic method could help reduce unnecessary radical surgery in the treatment of breast cancer.

Published
1998
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48. [Recurrent vulvar carcinoma at the Halle/S. University Gynecologic Clinic 1971-1990--diagnosis and results of therapy].

Author

Strauss HG and Lampe D

Subjects
Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell mortality, Carcinoma, Squamous Cell pathology, Female, Follow-Up Studies, Humans, Lymphatic Metastasis, Middle Aged, Neoplasm Recurrence, Local mortality, Neoplasm Recurrence, Local pathology, Neoplasm Staging, Survival Rate, Vulvar Neoplasms mortality, Vulvar Neoplasms pathology, Carcinoma, Squamous Cell surgery, Neoplasm Recurrence, Local surgery, Vulvar Neoplasms surgery
Abstract

We analysed the recurrences of vulvar carcinoma diagnosed at the Gynecological University Hospital of Halle/S. between 1971 and 1990. 37 cases were evaluated. 75.7% of all patients had a local recurrence of the vulvar region; no distant site of recurrent tumour outside the pelvis was described. Only 48.6% of the recurrences occurred within a period of two years after primary therapy. The five year survival after diagnosis of recurrent disease was 56%. The influence of potential prognostic factors on survival was evaluated by a multivariate analysis according to the Cox model. Only the localisation of recurrence represented a statistically significant prognostic factor. Patients with a local recurrent carcinoma had a significant survival advantage as compared to those cases with inguinal or pelvic node tumour (p = 0.0021).

Published
1994

49. [HELLP syndrome on the 6th puerperal day. Presentation of case reports].

Author

Strauss HG, Scheler C, and Röpke F

Subjects
Adult, Cesarean Section, Combined Modality Therapy, Critical Care, Fatal Outcome, Female, Fetal Death etiology, HELLP Syndrome mortality, HELLP Syndrome therapy, Humans, Infant, Newborn, Pre-Eclampsia diagnosis, Pre-Eclampsia mortality, Pre-Eclampsia therapy, Pregnancy, Puerperal Disorders mortality, Puerperal Disorders therapy, HELLP Syndrome diagnosis, Puerperal Disorders diagnosis
Abstract

We show by two case reports, that the HELLP-syndrome is the most severe form of pre-eclampsia and associated with a relative high maternal and perinatal mortality because of the sudden onset of the complications. In the first case report we describe the development of this syndrome after two eclamptical convulsions on the 6th day of puerperal period. A similar case has not been published yet in all literature. In the second report a mother died by rupture of the capsule of liver because of the HELLP-syndrome 72 hours after Section caesarea. We want to show, that caesarean section cannot avoid this complication. It is not in all cases the most advantageous procedure of delivery in patients with HELLP-syndrome.

Published
1994

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