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117 results on '"Strelau J"'

4. Growth/differentiation factor-15 (GDF-15), a novel member of the TGF-β superfamily, promotes survival of lesioned mesencephalic dopaminergic neurons in vitro and in vivo and is induced in neurons following cortical lesioning

Author

Strelau, J., Schober, A., Sullivan, A., Schilling, L., Unsicker, K., Horowski, R., editor, Mizuno, Y., editor, Olanow, C. W., editor, Poewe, W. H., editor, Riederer, P., editor, Stoessl, J. A., editor, and Youdim, M. B. H., editor

Published
2003
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5. GDF-15/MIC-1 a novel member of the TGF-ß superfamily

Author

Strelau, J., Böttner, M., Lingor, P., Suter-Crazzolara, C., Galter, D., Jaszai, J., Sullivan, A., Schober, A., Krieglstein, K., Unsicker, K., Riederer, P., editor, Calne, D. B., editor, Horowski, R., editor, Mizuno, Y., editor, Olanow, C. W., editor, Poewe, W., editor, and Youdim, M. B. H., editor

Published
2000
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12. Effect of Growth Differentiation Factor-15 (GDF-15) on the expression of apoptosis-relevant genes in a mouse-model of atherosclerosis

Author

Thogersen, J., Zügel, S., Bonaterra, G. A., Bendner, G., Vorwald, S., Fey, J., Traut, U., Strelau, J., and Kinscherf, R.

Subjects
ddc: 610, embryonic structures, 610 Medical sciences, Medicine
Abstract

[for full text, please go to the a.m. URL], 24. Jahrestagung der Deutschen Gesellschaft für Arterioskleroseforschung

Published
2011
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18. Effect of Growth Differentiation Factor-15 (GDF-15) on the expression of apoptosis-relevant genes in a mouse-model of atherosclerosis

Author

Thogersen, J, Zügel, S, Bonaterra, GA, Bendner, G, Vorwald, S, Fey, J, Traut, U, Strelau, J, Kinscherf, R, Thogersen, J, Zügel, S, Bonaterra, GA, Bendner, G, Vorwald, S, Fey, J, Traut, U, Strelau, J, and Kinscherf, R

Abstract

Growth differentiation factor-15 (GDF-15) is a distant and divergent member of the TGF-beta super family and is expressed in macrophages after stimulation by several biological mediators. Interactions between peripheral blood mononuclear cells (PBMCs) and those within plaques are suggested to be pathophysiologically relevant to lipid-induced atherosclerosis. We therefore postulated that the expression of GDF-15 is associated with the development and progression of atherosclerotic plaque, possibly through the regulation of apoptotic processes.

Published
2011

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Author

Strelau, J, Schmeer, C, Peterziel, H, Sackmann, T, Herold-Mende, C, Steiner, Hans, Weller, M, Unsicker, K, Strelau, J, Schmeer, C, Peterziel, H, Sackmann, T, Herold-Mende, C, Steiner, Hans, Weller, M, and Unsicker, K

Abstract

Recent studies have demonstrated growth-inhibiting effects of growth differentiation factor-15 (GDF-15) on different cancer cell lines invitro and on tumor growth in vivo. Here, we present data concerning expression of GDF-15 in glioblastoma. We found low levels of GDF-15 transcripts in primary glioblastoma. Thus, GDF-15 expression might be exploited as a useful indicator for distinguishing primary from other glial derived tumors. In contrast to the documented proapoptotic and anti-tumorigenic activities of GDF-15 in several cancer cell lines, our data suggest that GDF-15 does not decrease proliferation of glioblastoma cell lines, while its effects on invasiveness are not consistent.

Published
2008

24. Progressive Postnatal Motoneuron Loss in Mice Lacking GDF-15

Author

Strelau, J., primary, Strzelczyk, A., additional, Rusu, P., additional, Bendner, G., additional, Wiese, S., additional, Diella, F., additional, Altick, A. L., additional, von Bartheld, C. S., additional, Klein, R., additional, Sendtner, M., additional, and Unsicker, K., additional

Published
2009
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40. GDF-15/MIC-1 a novel member of the TGF-beta superfamily

Author

Strelau J, Böttner M, Paul Lingor, Suter-Crazzolara C, Galter D, Jaszai J, Sullivan A, Schober A, Krieglstein K, and Unsicker K

Subjects
Growth Differentiation Factor 15, Sequence Homology, Amino Acid, Transforming Growth Factor beta, Brain Injuries, Animals, Brain, Cytokines, Humans, RNA, Messenger, Cerebrospinal Fluid, Protein Structure, Tertiary
Abstract

We have cloned, expressed, and raised antibodies against a novel member of the TGF-beta superfamily, growth/differentiation factor-15 (GDF-15). The predicted protein is identical to macrophage inhibitory cytokine-1 (MIC-1), which was discovered simultaneously. GDF-15 is a more distant member of the TGF-beta superfamily and does not belong to one of the known TGF-beta subfamilies. In the CNS, GDF-15/MIC-1 mRNA is abundantly expressed by the choroid plexus. In addition we have preliminary evidence that GDF-15/MIC-1 is a potent trophic factor for selected classes of neurons in vitro and in vivo. Thus, GDF-15 is a novel neurotrophic factor with prospects for the treatment of disorders of the CNS.

50. Expression and putative functions of GDF-15, a member of the TGF-β superfamily, in human glioma and glioblastoma cell lines

Author

Tina Sackmann, Jens Strelau, Corina Schmeer, Klaus Unsicker, Heike Peterziel, Hans H. Steiner, Michael Weller, Christel Herold-Mende, University of Zurich, and Strelau, J

Subjects
Cancer Research, Growth Differentiation Factor 15, Apoptosis, 610 Medicine & health, Biology, In vivo, Cell Line, Tumor, Humans, Neoplasm Invasiveness, 1306 Cancer Research, Cell Proliferation, Glioblastoma cell, Cell growth, Glioma, Immunohistochemistry, In vitro, 10040 Clinic for Neurology, Cell biology, Oncology, Cell culture, embryonic structures, Cytokines, 2730 Oncology, GDF15, Tumor Suppressor Protein p53, Glioblastoma
Abstract

Recent studies have demonstrated growth-inhibiting effects of growth differentiation factor-15 (GDF-15) on different cancer cell lines invitro and on tumor growth in vivo. Here, we present data concerning expression of GDF-15 in glioblastoma. We found low levels of GDF-15 transcripts in primary glioblastoma. Thus, GDF-15 expression might be exploited as a useful indicator for distinguishing primary from other glial derived tumors. In contrast to the documented proapoptotic and anti-tumorigenic activities of GDF-15 in several cancer cell lines, our data suggest that GDF-15 does not decrease proliferation of glioblastoma cell lines, while its effects on invasiveness are not consistent.

Published
2008
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