Search

Your search keyword '"Stretea, Roland"' showing total 6 results
Start Over Author "Stretea, Roland"
6 results on '"Stretea, Roland"'

6. COX-2 as a potential biomarker and therapeutic target in melanoma.

Author

Tudor, Diana Valentina, Bâldea, Ioana, Lupu, Mihai, Kacso, Teodor, Kutasi, Eniko, Hopârtean, Andreea, Stretea, Roland, and Filip, Adriana Gabriela

Subjects
IMMUNOSUPPRESSION, INFLAMMATION
Abstract

With a constantly increasing incidence, cutaneous melanoma has raised the need for a better understanding of its complex microenvironment that may further guide therapeutic options. Melanoma is a model tumor in immuno-oncology. Inflammation represents an important hallmark of cancer capable of inducing and sustaining tumor development. The inflammatory process also orchestrates the adaptative immunosuppression of tumor cells that helps them to evade immune destruction. Besides its role in proliferation, angiogenesis, and apoptosis, cyclooxygenase-2 (COX-2) is a well-known promoter of immune suppression in melanoma. COX-2 inhibitors are closely involved in this condition. This review attempts to answer two controversial questions: is COX-2 a valuable prognostic factor? Among all COX-2 inhibitors, is celecoxib a suitable adjuvant in melanoma therapy? [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results