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17 results on '"Stritt, Manuel"'

1. NF-κB drives epithelial-mesenchymal mechanisms of lung fibrosis in a translational lung cell model

Author

Sieber, Patrick, primary, Schäfer, Anny, additional, Lieberherr, Raphael, additional, Caimi, Silvia L., additional, Lüthi, Urs, additional, Ryge, Jesper, additional, Bergmann, Jan H., additional, Le Goff, François, additional, Stritt, Manuel, additional, Blattmann, Peter, additional, Renault, Bérengère, additional, Rammelt, Patrick, additional, Sempere, Bruno, additional, Freti, Diego, additional, Studer, Rolf, additional, White, Eric S., additional, Birker-Robaczewska, Magdalena, additional, Boucher, Maxime, additional, and Nayler, Oliver, additional

Published
2023
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3. Ideas and Improvements for Semantic Wikis

Author

Fischer, Jochen, Gantner, Zeno, Rendle, Steffen, Stritt, Manuel, Schmidt-Thieme, Lars, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Sure, York, editor, and Domingue, John, editor

Published
2006
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6. Orbit image analysis machine learning software can be used for the histological quantification of acute ischemic stroke blood clots

Author

Fitzgerald, Seán, primary, Wang, Shunli, additional, Dai, Daying, additional, Murphree, Dennis H., additional, Pandit, Abhay, additional, Douglas, Andrew, additional, Rizvi, Asim, additional, Kadirvel, Ramanathan, additional, Gilvarry, Michael, additional, McCarthy, Ray, additional, Stritt, Manuel, additional, Gounis, Matthew J., additional, Brinjikji, Waleed, additional, Kallmes, David F., additional, and Doyle, Karen M., additional

Published
2019
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10. A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor

Author

Lotz-Jenne, Carina, primary, Lüthi, Urs, additional, Ackerknecht, Sabine, additional, Lehembre, François, additional, Fink, Tobias, additional, Stritt, Manuel, additional, Wirth, Matthias, additional, Pavan, Simona, additional, Bill, Ruben, additional, Regenass, Urs, additional, Christofori, Gerhard, additional, and Meyer-Schaller, Nathalie, additional

Published
2016
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11. Novel high–throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP2 and EP4 receptors.

Author

Sieber, Patrick, Schäfer, Anny, Lieberherr, Raphael, Le Goff, François, Stritt, Manuel, Welford, Richard W. D., Gatfield, John, Peter, Oliver, Nayler, Oliver, and Lüthi, Urs

Subjects
PULMONARY fibrosis, MYOFIBROBLASTS, EXTRACELLULAR matrix, CHEMICAL structure, MEDICAL screening
Abstract

Pathological features of pulmonary fibrosis include accumulation of myofibroblasts and increased extracellular matrix (ECM) deposition in lung tissue. Contractile α–smooth muscle actin (α–SMA)–expressing myofibroblasts that produce and secrete ECM are key effector cells of the disease and therefore represent a viable target for potential novel anti–fibrotic treatments. We used primary normal human lung fibroblasts (NHLF) in two novel high–throughput screening assays to discover molecules that inhibit or revert fibroblast–to–myofibroblast differentiation. A phenotypic high–content assay (HCA) quantified the degree of myofibroblast differentiation, whereas an impedance–based assay, multiplexed with MS / MS quantification of α–SMA and collagen 1 alpha 1 (COL1) protein, provided a measure of contractility and ECM formation. The synthetic prostaglandin E1 (PGE1) alprostadil, which very effectively and potently attenuated and even reversed TGF–β1–induced myofibroblast differentiation, was identified by screening a library of approved drugs. In TGF–β1–induced myofibroblasts the effect of alprostadil was attributed to activation of prostanoid receptor 2 and 4 (EP2 and EP4, respectively). However, selective activation of the EP2 or the EP4 receptor was already sufficient to prevent or reverse TGF–β1–induced NHLF myofibroblast transition. Our high–throughput assays identified chemical structures with potent anti–fibrotic properties acting through potentially novel mechanisms. [ABSTRACT FROM AUTHOR]

Published
2018
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13. Identification of Cathepsin L as a Potential Sex-Specific Biomarker for Renal Damage

Author

Bauer, Yasmina, primary, Hess, Patrick, additional, Qiu, Changbin, additional, Klenk, Axel, additional, Renault, Bérengère, additional, Wanner, Daniel, additional, Studer, Rolf, additional, Killer, Nina, additional, Stalder, Anna Katharina, additional, Stritt, Manuel, additional, Strasser, Daniel Stefan, additional, Farine, Hervé, additional, Kauser, Katalin, additional, Clozel, Martine, additional, Fischli, Walter, additional, and Nayler, Oliver, additional

Published
2011
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16. Ideas and Improvements for Semantic Wikis.

Author

Sure, York, Domingue, John, Fischer, Jochen, Gantner, Zeno, Rendle, Steffen, Stritt, Manuel, and Schmidt-Thieme, Lars

Abstract

We present an architecture for combining wikis containing hypertext with ontologies containing formal, structured information. A web-based ontology editor that supports collaborative work through versioning, transactions and management of simultaneous modifications is used for ontology evolution. In wiki pages, ontology information can be used to render dynamic content and answer user queries. Furthermore, query templates are introduced that simplify the use of queries for inexperienced users. The architecture allows easy integration with existing ontology frameworks and wiki engines. The usefulness of the approach is demonstrated by a prototypical implementation as well as a small case study. [ABSTRACT FROM AUTHOR]

Published
2006
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17. Integration of distributed computing into the drug discovery process

Author

von Korff, Modest, Rufener, Christian, Stritt, Manuel, Freyss, Joel, Bäär, Roman, and Sander, Thomas

Abstract

Grid computing offers an opportunity to gain massive computing power at low costs. We give a short introduction into the drug discovery process and exemplify the use of grid computing for image processing, docking and 3D pharmacophore descriptor calculations. The principle of a grid and its architecture are briefly explained. More emphasis is laid on the issues related to a company-wide grid installation and embedding the grid into the research process. The future of grid computing in drug discovery is discussed in the expert opinion section. Most needed, besides reliable algorithms to predict compound properties, is embedding the grid seamlessly into the discovery process. User friendly access to powerful algorithms without any restrictions, that is, by a limited number of licenses, has to be the goal of grid computing in drug discovery.

Published
2011
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