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1. Searching for new targets and treatments in the battle against squamous cell carcinoma of the head and neck, with specific focus on tumours of the tongue

Author

Sgaramella, Nicola, Gu, Xiaolian, Boldrup, Linda, Coates, Philip J., Fåhraeus, Robin, Califano, Luigi, Tartaro, Gianpaolo, Colella, Giuseppe, Norberg-Spaak, Lena, Strom, Adrian, Wilms, Torben, Lo Muzio, Lorenzo, Orabona, Giovanni Dell'Aversana, Santagata, Mario, Loljung, Lotta, Rossiello, Riccardo, Danielsson, Karin, Strindlund, Klas, Lillqvist, Sandra, Nylander, Karin, Sgaramella, Nicola, Gu, Xiaolian, Boldrup, Linda, Coates, Philip J., Fåhraeus, Robin, Califano, Luigi, Tartaro, Gianpaolo, Colella, Giuseppe, Norberg-Spaak, Lena, Strom, Adrian, Wilms, Torben, Lo Muzio, Lorenzo, Orabona, Giovanni Dell'Aversana, Santagata, Mario, Loljung, Lotta, Rossiello, Riccardo, Danielsson, Karin, Strindlund, Klas, Lillqvist, Sandra, and Nylander, Karin

Abstract

Squamous cell carcinoma of the head and neck, SCCHN, is a heterogeneous group of tumours not only concerning the site of origin but also regarding aetiology. The 5-year survival for the whole group of SCCHN tumours has not significantly improved over the last 20-25 years. Apart from tumour spread to lymph nodes, N status, gains and losses of specific chromosomes are the only factors shown to be independent prognostic markers for these tumours. Worldwide, an increasing number of people ≤ 40 years are seen being affected by tongue SCC, the most common tumour within the SCCHN group. Even without any clinical signs of metastasis, up to 30% of all tongue SCC have histologically detectable spread to lymph nodes. In this mini review, field cancerization, tumour microenvironment, the so called EMT (epithelial mesenchymal transition) process and the role of viruses in development of SCCHN are discussed as well as potential new therapeutic targets. For the group of tongue SCC, with the increasing incidence seen in young patients and particularly women, new data with impact on prognosis and treatment are urgently needed. But as long as data from the analyses of several sub sites are presented as valid for the whole group of tumours, this vital point is missed.

Published
2018
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2. Searching for New Targets and Treatments in the Battle Against Squamous Cell Carcinoma of the Head and Neck, with Specific Focus on Tumours of the Tongue

Author

Sgaramella, Nicola, primary, Gu, Xiaolian, additional, Boldrup, Linda, additional, Coates, Philip J, additional, Fahraeus, Robin, additional, Califano, Luigi, additional, Tartaro, Gianpaolo, additional, Colella, Giuseppe, additional, Spaak, Lena Norberg, additional, Strom, Adrian, additional, Wilms, Torben, additional, Muzio, Lorenzo Lo, additional, Orabona, Giovanni Dell`Aversana, additional, Santagata, Mario, additional, Loljung, Lotta, additional, Rossiello, Riccardo, additional, Danielsson, Karin, additional, Strindlund, Klas, additional, Lillqvist, Sandra, additional, and Nylander, Karin, additional

Published
2018
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3. Searching for New Targets and Treatments in the Battle Against Squamous Cell Carcinoma of the Head and Neck, with Specific Focus on Tumours of the Tongue

Author

Karin Danielsson, Torben Wilms, Xiaolian Gu, Philip J. Coates, Robin Fåhraeus, Lena Norberg Spaak, Gianpaolo Tartaro, Lorenzo Lo Muzio, Klas Strindlund, Riccardo Rossiello, Mario Santagata, Linda Boldrup, Karin Nylander, Luigi Califano, Nicola Sgaramella, Giovanni Dell'Aversana Orabona, Adrian Strom, Lotta Loljung, Sandra Lillqvist, Giuseppe Colella, Sgaramella, Nicola, Gu, Xiaolian, Boldrup, Linda, Coates, Philip J, Fahraeus, Robin, Califano, Luigi, Tartaro, Gianpaolo, Colella, Giuseppe, Spaak, Lena Norberg, Strom, Adrian, Wilms, Torben, Muzio, Lorenzo Lo, Orabona, Giovanni Dell'Aversana, Santagata, Mario, Loljung, Lotta, Rossiello, Riccardo, Danielsson, Karin, Strindlund, Kla, Lillqvist, Sandra, Nylander, Karin, Sgaramella, N, Gu, X, Boldrup, L, Coates, P, Fahraeus, R, Califano, L, Tartaro, Giorgio, Colella, G, Spaak, Ln, Strom, A, Wilms, T, Muzio, Ll, dell'aversana Orabona, G, Santagata, M, Loljung, L, Rossiello, R, Danielsson, K, Strindlund, K, Lillqvist, S, and Nylander, K.

Subjects
0301 basic medicine, Oncology, Herpesvirus 4, Human, Battle, Antineoplastic Agent, 0302 clinical medicine, Squamous cell carcinoma, Drug Discovery, Tumor Microenvironment, Head and neck, Papillomaviridae, Site of origin, media_common, Head and Neck Neoplasm, Microbial Sensitivity Test, Medicine (all), General Medicine, p63, Tongue Neoplasms, medicine.anatomical_structure, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Human, medicine.medical_specialty, HPV, Prognosi, media_common.quotation_subject, Antineoplastic Agents, Microbial Sensitivity Tests, Antiviral Agents, 03 medical and health sciences, Structure-Activity Relationship, Tongue, EBV, Internal medicine, medicine, Humans, Basal cell, miRNA, Antiviral Agent, Focus (computing), Heterogeneous group, business.industry, stomatognathic diseases, 030104 developmental biology, Therapy, Drug Screening Assays, Antitumor, business, Tongue Neoplasm
Abstract

Squamous cell carcinoma of the head and neck, SCCHN, is a heterogeneous group of tumours not only concerning the site of origin but also regarding aetiology. The 5-year survival for the whole group of SCCHN tumours has not significantly improved over the last 20-25 years. Apart from tumour spread to lymph nodes, N status, gains and losses of specific chromosomes are the only factors shown to be independent prognostic markers for these tumours. Worldwide, an increasing number of people ≤ 40 years are seen being affected by tongue SCC, the most common tumour within the SCCHN group. Even without any clinical signs of metastasis, up to 30% of all tongue SCC have histologically detectable spread to lymph nodes. In this mini review, field cancerization, tumour microenvironment, the so called EMT (epithelial mesenchymal transition) process and the role of viruses in development of SCCHN are discussed as well as potential new therapeutic targets. For the group of tongue SCC, with the increasing incidence seen in young patients and particularly women, new data with impact on prognosis and treatment are urgently needed. But as long as data from the analyses of several sub sites are presented as valid for the whole group of tumours, this vital point is missed.

Published
2017

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