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Texto completo: acesso restrito. p.47–55. Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2012-02-29T17:21:05Z No. of bitstreams: 1 Affective temperamental profiles are associated with white matter.pdf: 236313 bytes, checksum: 437ecb29de9d4e5412d6bfe66d2dc6dd (MD5) Made available in DSpace on 2012-02-29T17:21:05Z (GMT). No. of bitstreams: 1 Affective temperamental profiles are associated with white matter.pdf: 236313 bytes, checksum: 437ecb29de9d4e5412d6bfe66d2dc6dd (MD5) Previous issue date: 2011 Background: Patients with white matter hyperintensities (WMH) may be at higher risk for affective disorders and suicide. Affective temperaments may play a significant role in mood disorders. This study aimed to evaluate the eventual association between WMH, affective temperaments and suicidal behaviour in major affective disorder. Methods: A total of 318 patients with major affective disorders were consecutively admitted as psychiatric inpatient. A total of 247 were included and given, brain magnetic resonance imaging (MRI) and assessed with the Mini International Neuropsychiatric Interview (MINI), the Beck Hopelessness Scale (BHS), the Hamilton Depression Rating Scale (HDRS17), the Young Mania Rating Scale (YMRS) and the Temperament Evaluation of Memphis, Pisa, Paris and San Diego (TEMPS-A). Results: A total of 48% of patients had periventricular WMH (PWMH) and 39% of them had deep WMH (DWMH). Patients with higher dysthymia and lower hyperthymia (H-DCIA group) were more likely to have higherBHS scores (BHS 9=77% vs. 52%; pN0.001),moreWMH(46% vs. 29%; 2 n=3=9.90; pb0.05), higherMINI suicidal risk (54% vs. 42%; pb0.05), and more recent suicide attempts (24% vs. 14%; pb0.05), than patients with higher hyperthymia and lower dysthymia (H-H group). Limitations: The small sample size did not allow the generalization of the present findings. Conclusions: Differences among temperament groupsmeasured by the TEMPS-Aare associatedwith differences in their MRIs, indicating that different temperament profiles are associated with differences in the subcortical structures of the brain. The implications of the resultswere discussed.