167 results on '"Stucker, I"'
Search Results
2. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach
- Author
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Di Credico, G, Edefonti, V, Polesel, J, Pauli, F, Torelli, N, Serraino, D, Negri, E, Luce, D, Stucker, I, Matsuo, K, Brennan, P, Vilensky, M, Fernandez, L, Curado, M, Menezes, A, Daudt, A, Koifman, R, Wunsch-Filho, V, Holcatova, I, Ahrens, W, Lagiou, P, Simonato, L, Richiardi, L, Healy, C, Kjaerheim, K, Conway, D, Macfarlane, T, Thomson, P, Agudo, A, Znaor, A, Boaventura Rios, L, Toporcov, T, Franceschi, S, Herrero, R, Muscat, J, Olshan, A, Zevallos, J, La Vecchia, C, Winn, D, Sturgis, E, Li, G, Fabianova, E, Lissowska, J, Mates, D, Rudnai, P, Shangina, O, Swiatkowska, B, Moysich, K, Zhang, Z, Morgenstern, H, Levi, F, Smith, E, Lazarus, P, Bosetti, C, Garavello, W, Kelsey, K, Mcclean, M, Ramroth, H, Chen, C, Schwartz, S, Vaughan, T, Zheng, T, Menvielle, G, Boccia, S, Cadoni, G, Hayes, R, Purdue, M, Gillison, M, Schantz, S, Yu, G, Brenner, H, D'Souza, G, Gross, N, Chuang, S, Boffetta, P, Hashibe, M, Lee, Y, Dal Maso, L, Di Credico G., Edefonti V., Polesel J., Pauli F., Torelli N., Serraino D., Negri E., Luce D., Stucker I., Matsuo K., Brennan P., Vilensky M., Fernandez L., Curado M. P., Menezes A., Daudt A. W., Koifman R., Wunsch-Filho V., Holcatova I., Ahrens W., Lagiou P., Simonato L., Richiardi L., Healy C., Kjaerheim K., Conway D. I., Macfarlane T. V., Thomson P., Agudo A., Znaor A., Boaventura Rios L. F., Toporcov T. N., Franceschi S., Herrero R., Muscat J., Olshan A. F., Zevallos J. P., La Vecchia C., Winn D. M., Sturgis E. M., Li G., Fabianova E., Lissowska J., Mates D., Rudnai P., Shangina O., Swiatkowska B., Moysich K., Zhang Z. -F., Morgenstern H., Levi F., Smith E., Lazarus P., Bosetti C., Garavello W., Kelsey K., McClean M., Ramroth H., Chen C., Schwartz S. M., Vaughan T. L., Zheng T., Menvielle G., Boccia S., Cadoni G., Hayes R. B., Purdue M., Gillison M., Schantz S., Yu G. -P., Brenner H., D'Souza G., Gross N. D., Chuang S. -C., Boffetta P., Hashibe M., Lee Y. -C. A., Dal Maso L., Di Credico, G, Edefonti, V, Polesel, J, Pauli, F, Torelli, N, Serraino, D, Negri, E, Luce, D, Stucker, I, Matsuo, K, Brennan, P, Vilensky, M, Fernandez, L, Curado, M, Menezes, A, Daudt, A, Koifman, R, Wunsch-Filho, V, Holcatova, I, Ahrens, W, Lagiou, P, Simonato, L, Richiardi, L, Healy, C, Kjaerheim, K, Conway, D, Macfarlane, T, Thomson, P, Agudo, A, Znaor, A, Boaventura Rios, L, Toporcov, T, Franceschi, S, Herrero, R, Muscat, J, Olshan, A, Zevallos, J, La Vecchia, C, Winn, D, Sturgis, E, Li, G, Fabianova, E, Lissowska, J, Mates, D, Rudnai, P, Shangina, O, Swiatkowska, B, Moysich, K, Zhang, Z, Morgenstern, H, Levi, F, Smith, E, Lazarus, P, Bosetti, C, Garavello, W, Kelsey, K, Mcclean, M, Ramroth, H, Chen, C, Schwartz, S, Vaughan, T, Zheng, T, Menvielle, G, Boccia, S, Cadoni, G, Hayes, R, Purdue, M, Gillison, M, Schantz, S, Yu, G, Brenner, H, D'Souza, G, Gross, N, Chuang, S, Boffetta, P, Hashibe, M, Lee, Y, Dal Maso, L, Di Credico G., Edefonti V., Polesel J., Pauli F., Torelli N., Serraino D., Negri E., Luce D., Stucker I., Matsuo K., Brennan P., Vilensky M., Fernandez L., Curado M. P., Menezes A., Daudt A. W., Koifman R., Wunsch-Filho V., Holcatova I., Ahrens W., Lagiou P., Simonato L., Richiardi L., Healy C., Kjaerheim K., Conway D. I., Macfarlane T. V., Thomson P., Agudo A., Znaor A., Boaventura Rios L. F., Toporcov T. N., Franceschi S., Herrero R., Muscat J., Olshan A. F., Zevallos J. P., La Vecchia C., Winn D. M., Sturgis E. M., Li G., Fabianova E., Lissowska J., Mates D., Rudnai P., Shangina O., Swiatkowska B., Moysich K., Zhang Z. -F., Morgenstern H., Levi F., Smith E., Lazarus P., Bosetti C., Garavello W., Kelsey K., McClean M., Ramroth H., Chen C., Schwartz S. M., Vaughan T. L., Zheng T., Menvielle G., Boccia S., Cadoni G., Hayes R. B., Purdue M., Gillison M., Schantz S., Yu G. -P., Brenner H., D'Souza G., Gross N. D., Chuang S. -C., Boffetta P., Hashibe M., Lee Y. -C. A., and Dal Maso L.
- Abstract
Objectives: This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures. Materials and Methods: We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework. Results: For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30 years. In former smokers who quit ≥10 years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers. Conclusion: Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies
- Published
- 2019
3. Occupations and the Risk of Head and Neck Cancer: A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium
- Author
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Khetan, P. Boffetta, P. Luce, D. Stucker, I. Curado, M.P. Menezes, A. Wunsch-Filho, V. Ahrens, W. Lagiou, P. Serraino, D. Richiardi, L. Kjaerheim, K. Conway, D. Thomson, P. Muscat, J. Mates, D. Ramroth, H. Menvielle, G. Vaughan, T.L. Brenner, H. Lee, Y.-C.A. La Vecchia, C. Hashibe, M. Hashim, D.
- Abstract
Objective:To investigate the associations between head and neck cancer (HNC) risk and occupations.Methods:We harmonized data on occupations in a pooled analysis of 8839 HNC cases and 13,730 controls in International Head and Neck Cancer Epidemiology (INHANCE) consortium. Logistic regression was used to estimate odds ratios (ORs) for associations of occupations and HNC risk. Population attributable fraction (PAF) for occupations was calculated using the formula PEC×(OR-1)/OR.1Results:Trend of increasing HNC risk was found with increasing duration of employment for many occupations, including cooks (OR=1.36; 95% confidence interval [CI] 1.09 to 1.68), cleaners (OR=1.38; 95% CI 1.13 to 1.69), painters (OR=1.82; 95% CI 1.42 to 2.35). The PAF for a priori occupations was 14.5% (95% CI 7.1% to 21.9%) for HNC.Conclusions:We found associations between certain occupations and HNC risks, including for subsites, with a duration-response relationship. Copyright © 2019 American College of Occupational and Environmental Medicine.
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- 2019
4. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach
- Author
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Di Credico, G., Edefonti, V., Polesel, J., Pauli, F., Torelli, N., Serraino, D., Negri, E., Luce, D., Stucker, I., Matsuo, K., Brennan, P., Vilensky, M., Fernandez, L., Curado, M. P., Menezes, A., Daudt, A. W., Koifman, R., Wunsch-Filho, V., Holcatova, I., Ahrens, W., Lagiou, Pagona, Simonato, L., Richiardi, L., Healy, C., Kjaerheim, K., Conway, D. I., Macfarlane, T. V., Thomson, P., Agudo, A., Znaor, A., Boaventura Rios, L. F., Toporcov, T. N., Franceschi, S., Herrero, R., Muscat, J., Olshan, A. F., Zevallos, J. P., La Vecchia, C., Winn, D. M., Sturgis, E. M., Li, G., Fabianova, E., Lissowska, J., Mates, D., Rudnai, P., Shangina, O., Swiatkowska, B., Moysich, K., Zhang, Z. -F., Morgenstern, H., Levi, F., Smith, E., Lazarus, P., Bosetti, C., Garavello, W., Kelsey, K., Mcclean, M., Ramroth, H., Chen, C., Schwartz, S. M., Vaughan, T. L., Zheng, T., Menvielle, G., Boccia, Stefania, Cadoni, Gabriella, Hayes, R. B., Purdue, M., Gillison, M., Schantz, S., Yu, G. -P., Brenner, H., D'Souza, G., Gross, N. D., Chuang, S. -C., Boffetta, Paolo, Hashibe, M., Lee, Y. -C. A., Dal Maso, L., Lagiou P., Boccia S. (ORCID:0000-0002-1864-749X), Cadoni G. (ORCID:0000-0001-8244-784X), Boffetta P., Di Credico, G., Edefonti, V., Polesel, J., Pauli, F., Torelli, N., Serraino, D., Negri, E., Luce, D., Stucker, I., Matsuo, K., Brennan, P., Vilensky, M., Fernandez, L., Curado, M. P., Menezes, A., Daudt, A. W., Koifman, R., Wunsch-Filho, V., Holcatova, I., Ahrens, W., Lagiou, Pagona, Simonato, L., Richiardi, L., Healy, C., Kjaerheim, K., Conway, D. I., Macfarlane, T. V., Thomson, P., Agudo, A., Znaor, A., Boaventura Rios, L. F., Toporcov, T. N., Franceschi, S., Herrero, R., Muscat, J., Olshan, A. F., Zevallos, J. P., La Vecchia, C., Winn, D. M., Sturgis, E. M., Li, G., Fabianova, E., Lissowska, J., Mates, D., Rudnai, P., Shangina, O., Swiatkowska, B., Moysich, K., Zhang, Z. -F., Morgenstern, H., Levi, F., Smith, E., Lazarus, P., Bosetti, C., Garavello, W., Kelsey, K., Mcclean, M., Ramroth, H., Chen, C., Schwartz, S. M., Vaughan, T. L., Zheng, T., Menvielle, G., Boccia, Stefania, Cadoni, Gabriella, Hayes, R. B., Purdue, M., Gillison, M., Schantz, S., Yu, G. -P., Brenner, H., D'Souza, G., Gross, N. D., Chuang, S. -C., Boffetta, Paolo, Hashibe, M., Lee, Y. -C. A., Dal Maso, L., Lagiou P., Boccia S. (ORCID:0000-0002-1864-749X), Cadoni G. (ORCID:0000-0001-8244-784X), and Boffetta P.
- Abstract
Objectives: This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures. Materials and Methods: We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework. Results: For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30 years. In former smokers who quit ≥10 years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers. Conclusion: Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.
- Published
- 2019
5. Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years
- Author
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Taioli, E, Gaspari, L, Benhamou, S, Boffetta, P, Brockmoller, J, Butkiewicz, D, Cascorbi, I, Clapper, ML, Dolzan, V, Haugen, A, Hirvonen, A, Husgafvel-Pursiainen, K, Kalina, I, Kremers, P, Le Marchand, L, London, S, Rannug, A, Romkes, M, Schoket, B, Seidegard, J, Strange, RC, Stucker, I, To-Figueras, J, and Garte, S
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- 2003
6. Alcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study
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Fehringer, G., Brenner, D. R., Zhang, Z. -F., Lee, Y. -C. A., Matsuo, K., Ito, H., Lan, Q., Vineis, P., Johansson, M., Overvad, K., Riboli, E., Trichopoulou, A., Sacerdote, C., Stucker, I., Boffetta, P., Brennan, P., Christiani, D. C., Hong, Y. -C., L, i, M. T., Morgenstern, H., Schwartz, A. G., Wenzlaff, A. S., Rennert, G., McLaughlin, J. R., Harris, C. C., Olivo-Marston, S., Orlow, I., Park, B. J., Zauderer, M., Barros Dios, J. M., Ruano Raviña, A., Siemiatycki, J., Koushik, A., Lazarus, P., Fernández-Somoano, A., Tardon, A., Le March, Brenner, H., Saum, K. -U., Duell, E. J., Andrew, A. S., Szeszenia-Dabrowska, N., Lissowska, J., Zaridze, D., Rudnai, P., Fabianova, E., Mates, D., Foretova, L., Janout, V., Bencko, V., Holcatova, I., Pesatori, A. C., Consonni, D., Olsson, A., Straif, K., Hung, R. J., and Fehringer, G. and Brenner, D.R. and Zhang, Z.-F. and Lee, Y.-C.A. and Matsuo, K. and Ito, H. and Lan, Q. and Vineis, P. and Johansson, M. and Overvad, K. and Riboli, E. and Trichopoulou, A. and Sacerdote, C. and Stucker, I. and Boffetta, P. and Brennan, P. and Christiani, D.C. and Hong, Y.-C. and Landi, M.T. and Morgenstern, H. and Schwartz, A.G. and Wenzlaff, A.S. and Rennert, G. and McLaughlin, J.R. and Harris, C.C. and Olivo-Marston, S. and Orlow, I. and Park, B.J. and Zauderer, M. and Barros Dios, J.M. and Ruano Raviña, A. and Siemiatycki, J. and Koushik, A. and Lazarus, P. and Fernández-Somoano, A. and Tardon, A. and Le Marchand, L. and Brenner, H. and Saum, K.-U. and Duell, E.J. and Andrew, A.S. and Szeszenia-Dabrowska, N. and Lissowska, J. and Zaridze, D. and Rudnai, P. and Fabianova, E. and Mates, D. and Foretova, L. and Janout, V. and Bencko, V. and Holcatova, I. and Pesatori, A.C. and Consonni, D. and Olsson, A. and Straif, K. and Hung, R.J.
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Male ,Asia ,Alcohol Drinking ,alcohol consumption ,sex difference ,cohort analysi ,environmental exposure ,cancer risk ,high risk patient ,Article ,smoking ,liquor ,adverse effect ,middle aged ,controlled study ,smoking, Aged ,human ,Alcoholic Beverage ,wine ,risk reduction ,alcohol ,adult ,Risk Factor ,disease association ,drinking behavior ,occupational exposure ,case control study ,lung adenocarcinoma ,major clinical study ,Europe ,Lung Neoplasm ,aged ,lung cancer ,female ,North America ,pathology ,beer ,small cell lung cancer ,Cohort Studie ,Case-Control Studie ,squamous cell lung carcinoma - Abstract
It is not clear whether alcohol consumption is associated with lung cancer risk. The relationship is likely confounded by smoking, complicating the interpretation of previous studies. We examined the association of alcohol consumption and lung cancer risk in a large pooled international sample, minimizing potential confounding of tobacco consumption by restricting analyses to never smokers. Our study included 22 case-control and cohort studies with a total of 2548 never-smoking lung cancer patients and 9362 never-smoking controls from North America, Europe and Asia within the International Lung Cancer Consortium (ILCCO) and SYNERGY Consortium. Alcohol consumption was categorized into amounts consumed (grams per day) and also modelled as a continuous variable using restricted cubic splines for potential non-linearity. Analyses by histologic sub-type were included. Associations by type of alcohol consumed (wine, beer and liquor) were also investigated. Alcohol consumption was inversely associated with lung cancer risk with evidence most strongly supporting lower risk for light and moderate drinkers relative to non-drinkers (>0–4.9 g per day: OR = 0.80, 95% CI = 0.70–0.90; 5–9.9 g per day: OR = 0.82, 95% CI = 0.69–0.99; 10–19.9 g per day: OR = 0.79, 95% CI = 0.65–0.96). Inverse associations were found for consumption of wine and liquor, but not beer. The results indicate that alcohol consumption is inversely associated with lung cancer risk, particularly among subjects with low to moderate consumption levels, and among wine and liquor drinkers, but not beer drinkers. Although our results should have no relevant bias from the confounding effect of smoking we cannot preclude that confounding by other factors contributed to the observed associations. Confounding in relation to the non-drinker reference category may be of particular importance. © 2017 UICC
- Published
- 2017
7. Lung Cancer Among Firefighters: Smoking-Adjusted Risk Estimates in a Pooled Analysis of Case-Control Studies
- Author
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Bigert, C, Gustavsson, P, Straif, K, Taeger, D, Pesch, B, Kendzia, B, Schuz, J, Stucker, I, Guida, F, Bruske, I, Wichmann, H E, Pesatori, A C, Landi, M T, Caporaso, N, Tse, L A, Yu, I T, Siemiatycki, J, Lavoue, J, Richiardi, L, Mirabelli, D, Simonato, L, Jockel, K H, Ahrens, W, Pohlabeln, H, Tardon, A, Zaridze, D, Field, J K, t Mannetje, A, Pearce, N, McLaughlin, J, Demers, P, Szeszenia-Dabrowska, N, Lissowska, J, Rudnai, P, Fabianova, E, Stanescu Dumitru, R, Bencko, V, Foretova, L, Janout, V, Boffetta, P, Peters, S, Vermeulen, R, Kromhout, H, Bruning, T, Olsson, A C, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, dIRAS RA-I&I RA, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, dIRAS RA-I&I RA, Bigert, C., Gustavsson, P., Straif, K., Taeger, D., Pesch, B., Kendzia, B., Schüz, J., Stücker, I., Guida, F., Brüske, I., Wichmann, H.-E., Pesatori, A.C., Landi, M.T., Caporaso, N., Tse, L.A., Yu, I.T.-S., Siemiatycki, J., Lavoué, J., Richiardi, L., Mirabelli, D., Simonato, L., Jöckel, K.-H., Ahrens, W., Pohlabeln, H., Tardón, A., Zaridze, D., Field, J.K., Mannetje, A., Pearce, N., McLaughlin, J., Demers, P., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Dumitru, R.S., Bencko, V., Foretova, L., Janout, V., Boffetta, P., Peters, S., Vermeulen, R., Kromhout, H., Brüning, T., and Olsson, A.C.
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Gerontology ,Canada ,China ,Lung Neoplasms ,Medizin ,Logistic regression ,Article ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Occupational Exposure ,Odds Ratio ,Medicine ,Humans ,030212 general & internal medicine ,Lung cancer ,Cell specific ,business.industry ,Environmental and Occupational Health ,Smoking ,Public Health, Environmental and Occupational Health ,Absolute risk reduction ,Case-control study ,Odds ratio ,medicine.disease ,030210 environmental & occupational health ,Europe ,Occupational Diseases ,Pooled analysis ,Case-Control Studies ,Firefighters ,Lung cancer - firefighters ,Public Health ,Occupational exposure ,business ,Demography ,New Zealand - Abstract
Objectives: The aim of this study was to explore lung cancer risk among firefighters, with adjustment for smoking. Methods: We used pooled information from the SYNERGY project including 14 case-control studies conducted in Europe, Canada, New Zealand, and China, with lifetime work histories and smoking habits for 14,748 cases of lung cancer and 17,543 controls. We estimated odds ratios by unconditional logistic regression with adjustment for smoking and having ever been employed in a job known to present an excess risk of lung cancer. Results: There was no increased lung cancer risk overall or by specific cell type among firefighters (n=190), neither before nor after smoking adjustment. We observed no significant exposure-response relationship in terms of work duration. Conclusions: We found no evidence of an excess lung cancer risk related to occupational exposure as a firefighter. Copyright © 2016 American College of Occupational and Environmental Medicine. Unauthorized reproduction of this article is prohibited.
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- 2016
8. Risk of fatal industrial accidents and death from other external causes among asphalt workers
- Author
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Burstyn, I., Boffetta, P., Jarvholm, B., Partanen, T., Svane, O., Langard, S., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D., Ahrens, W., Bergdahl, I., Cenee, S., Hooiveld, M., Randem, B.G., Johansen, C., Ferro, G., and Kromhout, H.
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Health - Abstract
The hypothesis that asphalt workers are at increased risk of mortality from industrial accidents and other external causes was tested. Mortality rates for external and violent causes of death in [...]
- Published
- 2004
9. Incidence of malignancy in patients treated for antineutrophil cytoplasm antibody-associated vasculitis: follow-up data from European Vasculitis Study Group clinical trials
- Author
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Heijl, C., Harper, L., Flossmann, O., Stucker, I., Scott, D.G.I., Watts, R.A., Hoglund, P., Westman, K., Mahr, A., European Vasculitis Study Grp EUVA, and Faculteit Medische Wetenschappen/UMCG
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Cyclophosphamide ,Immunology ,Population ,BLADDER-CANCER ,Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis ,THERAPY ,General Biochemistry, Genetics and Molecular Biology ,WEGENERS-GRANULOMATOSIS ,Rheumatology ,Neoplasms ,Internal medicine ,Azathioprine ,CYCLOPHOSPHAMIDE ,medicine ,Humans ,Multicenter Studies as Topic ,Immunology and Allergy ,COHORT ,POLYANGIITIS ,education ,METAANALYSIS ,Aged ,Randomized Controlled Trials as Topic ,RISK ,education.field_of_study ,Bladder cancer ,business.industry ,Cancer ,Middle Aged ,medicine.disease ,RANDOMIZED-TRIAL ,METHOTREXATE ,Europe ,Female ,Skin cancer ,Epidemiologic Methods ,Microscopic polyangiitis ,Vasculitis ,Granulomatosis with polyangiitis ,business ,Immunosuppressive Agents ,medicine.drug - Abstract
Objectives Because standard immunosuppressive treatment for antineutrophil cytoplasm antibody-associated vasculitis (AAV) (granulomatosis with polyangiitis (Wegener's) (GPA) and microscopic polyangiitis (MPA)) has been associated with a significant risk of developing cancer, the cancer incidence of treated AAV patients was assessed.Methods This analysis concerned 535 patients with newly diagnosed AAV from 15 countries who had been enrolled between 1995 and 2002 in four European clinical trials. Over the period 2004-7, study participants' follow-up events were updated, including cancers diagnosed. Age, sex and area-standardised incidence ratios (SIR) and their 95% CI were calculated by linkage to five national cancer databases.Results During the 2650 person-years' observation period, 50 cancers were diagnosed in 46 patients. SIR (95% CI) were 1.58 (1.17 to 2.08) for cancers at all sites, 1.30 (0.90 to 1.80) for cancers at all sites excluding non-melanoma skin cancer (NMSC), 2.41 (0.66 to 6.17) for bladder cancer, 3.23 (0.39 to 11.65) for leukaemia, 1.11 (0.03 to 6.19) for lymphoma and 2.78 (1.56 to 4.59) for NMSC. Subgroup SIR for cancers at all sites were 1.92 (1.31 to 2.71) for GPA and 1.20 (0.71 to 1.89) for MPA.Conclusions Cancer rates for AAV patients treated with conventional immunosuppressive therapy exceeded those expected for the general population. This cancer excess was largely driven by an increased incidence of NMSC. The smaller cancer risk magnitude in this cohort, compared with previous studies, might reflect less extensive use of cyclophosphamide in current treatment protocols. Longer follow-up data are warranted to appraise the risk of developing cancers later during the course of AAV.
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- 2011
10. Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries
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Conway, D.I. Brenner, D.R. McMahon, A.D. Macpherson, L.M.D. Agudo, A. Ahrens, W. Bosetti, C. Brenner, H. Castellsague, X. Chen, C. Curado, M.P. Curioni, O.A. Maso, L.D. Daudt, A.W. De Gois Filho, J.F. D'Souza, G. Edefonti, V. Fabianova, E. Fernandez, L. Franceschi, S. Gillison, M. Hayes, R.B. Healy, C.M. Herrero, R. Holcatova, I. Jayaprakash, V. Kelsey, K. Kjaerheim, K. Koifman, S. La Vecchia, C. Lagiou, P. Lazarus, P. Levi, F. Lissowska, J. Luce, D. Macfarlane, T.V. Mates, D. Matos, E. McClean, M. Menezes, A.M. Menvielle, G. Merletti, F. Morgenstern, H. Moysich, K. Müller, H. Muscat, J. Olshan, A.F. Purdue, M.P. Ramroth, H. Richiardi, L. Rudnai, P. Schantz, S. Schwartz, S.M. Shangina, O. Simonato, L. Smith, E. Stucker, I. Sturgis, E.M. Szeszenia-Dabrowska, N. Talamini, R. Thomson, P. Vaughan, T.L. Wei, Q. Winn, D.M. Wunsch-Filho, V. Yu, G.-P. Zhang, Z.-F. Zheng, T. Znaor, A. Boffetta, P. Chuang, S.-C. Ghodrat, M. Lee, Y.-C.A. Hashibe, M. Brennan, P.
- Abstract
Low socioeconomic status has been reported to be associated with head and neck cancer risk. However, previous studies have been too small to examine the associations by cancer subsite, age, sex, global region and calendar time and to explain the association in terms of behavioral risk factors. Individual participant data of 23,964 cases with head and neck cancer and 31,954 controls from 31 studies in 27 countries pooled with random effects models. Overall, low education was associated with an increased risk of head and neck cancer (OR 5 2.50; 95% CI 5 2.02-3.09). Overall one-third of the increased risk was not explained by differences in the distribution of cigarette smoking and alcohol behaviors; and it remained elevated among never users of tobacco and nondrinkers (OR 5 1.61; 95% CI 5 1.13-2.31). More of the estimated education effect was not explained by cigarette smoking and alcohol behaviors: in women than in men, in older than younger groups, in the oropharynx than in other sites, in South/Central America than in Europe/North America and was strongest in countries with greater income inequality. Similar findings were observed for the estimated effect of low versus high household income. The lowest levels of income and educational attainment were associated with more than 2-fold increased risk of head and neck cancer, which is not entirely explained by differences in the distributions of behavioral risk factors for these cancers and which varies across cancer sites, sexes, countries and country income inequality levels. © 2014 UICC.
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- 2015
11. Lung Cancer Among Firefighters: Smoking-Adjusted Risk Estimates in a Pooled Analysis of Case-Control Studies
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LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, dIRAS RA-I&I RA, Bigert, C, Gustavsson, P, Straif, K, Taeger, D, Pesch, B, Kendzia, B, Schuz, J, Stucker, I, Guida, F, Bruske, I, Wichmann, H E, Pesatori, A C, Landi, M T, Caporaso, N, Tse, L A, Yu, I T, Siemiatycki, J, Lavoue, J, Richiardi, L, Mirabelli, D, Simonato, L, Jockel, K H, Ahrens, W, Pohlabeln, H, Tardon, A, Zaridze, D, Field, J K, t Mannetje, A, Pearce, N, McLaughlin, J, Demers, P, Szeszenia-Dabrowska, N, Lissowska, J, Rudnai, P, Fabianova, E, Stanescu Dumitru, R, Bencko, V, Foretova, L, Janout, V, Boffetta, P, Peters, S, Vermeulen, R, Kromhout, H, Bruning, T, Olsson, A C, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, dIRAS RA-I&I RA, Bigert, C, Gustavsson, P, Straif, K, Taeger, D, Pesch, B, Kendzia, B, Schuz, J, Stucker, I, Guida, F, Bruske, I, Wichmann, H E, Pesatori, A C, Landi, M T, Caporaso, N, Tse, L A, Yu, I T, Siemiatycki, J, Lavoue, J, Richiardi, L, Mirabelli, D, Simonato, L, Jockel, K H, Ahrens, W, Pohlabeln, H, Tardon, A, Zaridze, D, Field, J K, t Mannetje, A, Pearce, N, McLaughlin, J, Demers, P, Szeszenia-Dabrowska, N, Lissowska, J, Rudnai, P, Fabianova, E, Stanescu Dumitru, R, Bencko, V, Foretova, L, Janout, V, Boffetta, P, Peters, S, Vermeulen, R, Kromhout, H, Bruning, T, and Olsson, A C
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- 2016
12. Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium.
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Huang, R., Wei, Y., Hung, R.J., Liu, G., Su, L., Zhang, R., Zong, X., Zhang, Z.F., Morgenstern, H., Bruske, I., Heinrich, J., Hong, Y.C., Kim, J.H., Cote, M., Wenzlaff, A., Schwartz, A.G., Stucker, I., McLaughlin, J., Marcus, M.W., Davies, M.P., Liloglou, T., Field, J.K., Matsuo, K., Barnett, M., Thornquist, M., Goodman, G., Wang, Y., Chen, S., Yang, P., Duell, E.J., Andrew, A.S., Lazarus, P., Muscat, J., Woll, P., Horsman, J., Dawn Teare, M., Flugelman, A., Rennert, G., Zhang, Y, Brenner, H., Stegmaier, C., Heijden, E. van der, Aben, K.K.H., Kiemeney, L.A., Barros-Dios, J., Perez-Rios, M., Ruano-Ravina, A., Caporaso, N.E., Bertazzi, P.A., Landi, M.T., Dai, J., Shen, H., Fernandez-Tardon, G., Rodriguez-Suarez, M., Tardon, A., Christiani, D.C., Huang, R., Wei, Y., Hung, R.J., Liu, G., Su, L., Zhang, R., Zong, X., Zhang, Z.F., Morgenstern, H., Bruske, I., Heinrich, J., Hong, Y.C., Kim, J.H., Cote, M., Wenzlaff, A., Schwartz, A.G., Stucker, I., McLaughlin, J., Marcus, M.W., Davies, M.P., Liloglou, T., Field, J.K., Matsuo, K., Barnett, M., Thornquist, M., Goodman, G., Wang, Y., Chen, S., Yang, P., Duell, E.J., Andrew, A.S., Lazarus, P., Muscat, J., Woll, P., Horsman, J., Dawn Teare, M., Flugelman, A., Rennert, G., Zhang, Y, Brenner, H., Stegmaier, C., Heijden, E. van der, Aben, K.K.H., Kiemeney, L.A., Barros-Dios, J., Perez-Rios, M., Ruano-Ravina, A., Caporaso, N.E., Bertazzi, P.A., Landi, M.T., Dai, J., Shen, H., Fernandez-Tardon, G., Rodriguez-Suarez, M., Tardon, A., and Christiani, D.C.
- Abstract
1 november 2015, Contains fulltext : 156878.pdf (publisher's version ) (Open Access)
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- 2015
13. Urine mutagenicity, chromosomal abnormalities and sister chromatid exchanges in lymphocytes of nurses handling cytostatic drugs
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Stucker, I., Hirsch, A., Doloy, T., Bastie-Sigeac, I., and Hemon, D.
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- 1986
- Full Text
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14. Occupational exposure to organic dust increases lung cancer risk in the general population
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Peters, S., Kromhout, H., Olsson, A.C., Wichmann, H.E., Bruske, I., Consonni, D., Landi, M.T., Caporaso, N., Siemiatycki, J., Richiardi, L., Mirabelli, D., Simonato, L., Gustavsson, P., Plato, N., Jockel, K.H., Ahrens, W., Pohlabeln, H., Boffetta, P., Brennan, P., Zaridze, D., Cassidy, A., Lissowska, J, Szeszenia-Dabrowska, N., Rudnai, P., Fabianova, E., Forastiere, F., Bencko, V., Foretova, L., Janout, V., Stucker, I., Dumitru, R.S., Benhamou, S., Bueno-de-Mesquita, B., Kendzia, B., Pesch, B., Straif, K., Bruning, T., Vermeulen, R., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Peters, S., Kromhout, H., Olsson, A.C., Wichmann, H.-E., Brüske, I., Consonni, D., Landi, M.T., Caporaso, N., Siemiatycki, J., Richiardi, L., Mirabelli, D., Simonato, L., Gustavsson, P., Plato, N., Jöckel, K.-H., Ahrens, W., Pohlabeln, H., Boffetta, P., Brennan, P., Zaridze, D., Cassidy, A., Lissowska, J., Szeszenia-Dabrowska, N., Rudnai, P., Fabianova, E., Forastiere, F., Bencko, V., Foretova, L., Janout, V., Stücker, I., Dumitru, R.S., Benhamou, S., Bueno-de-Mesquita, B., Kendzia, B., Pesch, B., Straif, K., Brüning, T., Vermeulen, R., Risk Assessment of Toxic and Immunomodulatory Agents, and Dep IRAS
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Adult ,Male ,Pulmonary and Respiratory Medicine ,Canada ,Lung Neoplasms ,case-control study ,Population ,Medizin ,Cumulative Exposure ,Logistic regression ,Article ,Toxicology ,Occupational Exposure ,Environmental health ,Humans ,Medicine ,Lung cancer ,education ,Aged ,Asthma ,education.field_of_study ,business.industry ,Smoking ,Case-control study ,Public Health, Environmental and Occupational Health ,Dust ,Middle Aged ,medicine.disease ,Occupational exposure to organic du ,respiratory tract diseases ,Europe ,Occupational Diseases ,lung cancer ,Quartile ,Case-Control Studies ,Meta-analysis ,Female ,business - Abstract
Background: Organic dust is a complex mixture of particulate matter from microbial, plant or animal origin. Occupations with exposure to animal products have been associated with an increased lung cancer risk, while exposure to microbial components (eg, endotoxin) has been associated with a decreased risk. To date there has not been a comprehensive evaluation of the possible association between occupational organic dust exposure (and its specific constituents) and lung cancer risk in the general population. Methods: The SYNERGY project has pooled information on lifetime working and smoking from 13 300 lung cancer cases and 16 273 controls from 11 case - control studies conducted in Europe and Canada. A newly developed general population job-exposure matrix (assigning no, low or high exposure to organic dust, endotoxin, and contact with animals or fresh animal products) was applied to determine level of exposure. ORs for lung cancer were estimated by logistic regression, adjusted for age, sex, study, cigarette pack-years, time since quitting smoking, and ever employment in occupations with established lung cancer risk. Results: Occupational organic dust exposure was associated with increased lung cancer risk. The second to the fourth quartile of cumulative exposure showed significant risk estimates ranging from 1.12 to 1.24 in a dose-dependent manner (p
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- 2012
15. Polycyclic aromatic hydrocarbons and fatal ischemic heart disease
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Burstyn, I., Kromhout, H., Partanen, T.J., Svane, O., Langard, S., Ahrens, W., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D.J.J., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B., Boffetta, P., Faculteit Diergeneeskunde, Secretariat, U754, Unit of Environment Cancer Epidemiology, IARC, Division of Occupational and Environmental Health, Institute for Risk Assessment (IRAS), Utrecht University [Utrecht], Department of Public Health Sciences, University of Alberta, Unit of Excellence for Psychosocial Factors, Finnish Institute of Occupational Health, Central American Institute for Studies on Toxic Substances, Universidad National, Danish Working Environment Service, Centre for Occupational and Environmental Medicine, Riskhospitalet University Hospital, Bremen Institute for Prevention Research and Social Medicine, Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Occupational Cancer Department, National Institute of Occupational and Environmental Health, Institute of Cancer Epidemiology, Danish Cancer Society, Burstyn, I., Kromhout, H., Partanen, T., Svane, O., Langård, S., Ahrens, W., Kauppinen, T., Stücker, I., Shaham, J., Heederik, D., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B.G., Boffetta, P., and Faculteit Diergeneeskunde
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Male ,Epidemiology ,Denmark ,Myocardial Ischemia ,MESH: Occupational Exposure ,MESH: Cause of Death ,chemistry.chemical_compound ,Risk Factors ,MESH: Risk Factors ,Cause of Death ,Germany ,Determinants in Health and Disease [EBP 1] ,Israel ,Polycyclic Aromatic Hydrocarbons ,Finland ,MESH: Finland ,Confounding ,Smoking ,Absolute risk reduction ,MESH: Israel ,Confounding Factors, Epidemiologic ,Occupational Diseases ,Cohort ,Benzopyrene ,MESH: Myocardial Ischemia ,France ,MESH: Occupational Diseases ,medicine.medical_specialty ,MESH: Smoking ,Ischemic heart disease ,Coronacrisis-Taverne ,Occupational medicine ,MESH: Polycyclic Hydrocarbons, Aromatic ,Interventional oncology [UMCN 1.5] ,Environmental health ,Occupational Exposure ,medicine ,Humans ,cardiovascular diseases ,Risk factor ,MESH: Germany ,MESH: Denmark ,MESH: Humans ,business.industry ,MESH: Confounding Factors (Epidemiology) ,MESH: Male ,MESH: France ,chemistry ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Relative risk ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business - Abstract
Background: Several toxicologic and epidemiologic studies have produced evidence that occupational exposure to polycyclic aromatic hydrocarbons (PAH) is a risk factor for ischemic heart disease (IHD). However, a clear exposure-response relation has not been demonstrated. Methods: We studied a relation between exposure to PAH and mortality from IHD (418 cases) in a cohort of 12,367 male asphalt workers from Denmark, Finland, France, Germany, Israel, The Netherlands and Norway. The earliest follow up (country-specific) started in 1953 and the latest ended in 2000, averaging 17 years. Exposures to benzo(a)pyrene were assessed quantitatively using measurement-driven exposure models. Exposure to coal tar was assessed in a semiquantitative manner on the basis of information supplied by company representatives. We carried out sensitivity analyses to assess potential confounding by tobacco smoking. Results: Both cumulative and average exposure indices for benzo(a)pyrene were positively associated with mortality from IHD. The highest relative risk for fatal IHD was observed for average benzo(a)pyrene exposures of 273 ng/m 3 or higher, for which the relative risk was 1.64 (95% confidence interval = 1.13-2.38). Similar results were obtained for coal tar exposure. Sensitivity analysis indicated that even in a realistic scenario of confounding by smoking, we would observe approximately 20% to 40% excess risk in IHD in the highest PAH-exposure categories. Conclusions: Our results lend support to the hypothesis that occupational PAH exposure causes fatal IHD and demonstrate a consistent exposure-response relation for this association. Copyright © 2005 by Lippincott Williams & Wilkins.
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- 2005
16. Risk of fatal industrial accidents and death from other external causes among asphalt workers
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Burstyn, I., Boffetta, P., Jarvholm, B., Partanen, T., Svane, O., Langard, S., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D., Ahrens, W., Bergdahl, I., Cenee, S., Hooiveld, M., Randem, Bg, christoffer johansen, Ferro, G., Kromhout, H., Division of Occupational and Environmental Health, Institute for Risk Assessment (IRAS), Utrecht University [Utrecht], Unit of Environment Cancer Epidemiology, IARC, Occupational Medicine, Department of Public Health and Clinical Medicine, Umea University Hospital, Unit of Excellence for Psychosocial Factors, Finnish Institute of Occupational Health, Danish Working Environment Service, Centre for Occupational and Environmental Medicine, Riskhospitalet University Hospital, Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Occupational Cancer Department, National Institute of Occupational and Environmental Health, Bremen Institute for Prevention Research and Social Medicine, Institute of Cancer Epidemiology, Danish Cancer Society, Secretariat, U754, Universiteit Utrecht, Faculteit Diergeneeskunde, Burstyn, I., Boffetta, P., Järvholm, B., Partanen, T., Svane, O., Langård, S., Kauppinen, T., Stücker, I., Shaham, J., Heederik, D., Ahrens, W., Bergdahl, I., Cenée, S., Hooiveld, M., Randem, B.G., Johansen, C., Ferro, G., and Kromhout, H.
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Adult ,Male ,MESH: Accidents, Traffic ,Time Factors ,Risk fatal industrial accidents death external causes asphalt workers ,Coronacrisis-Taverne ,Short Report ,MESH: Risk Assessment ,Risk Assessment ,MESH: Cause of Death ,Cohort Studies ,Interventional oncology [UMCN 1.5] ,MESH: Accidents, Occupational ,Cause of Death ,MESH: Hydrocarbons ,Determinants in Health and Disease [EBP 1] ,Accidents, Occupational ,Humans ,MESH: Cohort Studies ,MESH: Humans ,MESH: Middle Aged ,MESH: Time Factors ,Accidents, Traffic ,MESH: Adult ,Middle Aged ,MESH: Male ,Hydrocarbons ,Europe ,Suicide ,MESH: Suicide ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,MESH: Europe - Abstract
Item does not contain fulltext The hypothesis that asphalt workers are at increased risk of mortality from industrial accidents and other external causes was tested. Mortality rates for external and violent causes of death in a cohort of asphalt industry employees from seven European countries and Israel were compared to that of the general population. There was no evidence that mortality from external causes was increased among long term employees in asphalt application and mixing. There was an increased risk for mortality due to external causes among short term workers. However, none of the fatal accidents among short term workers appear to have occurred during employment in the studied asphalt companies. Overall, no evidence was found supporting the hypothesis that asphalt workers are at increased risk of fatal industrial or road accidents. Mortality from other external causes did not increase in this population as a whole, but increased risks among short term workers deserve further attention.
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- 2003
17. Cancer mortality among European asphalt workers: An international epidemiological study. II. Exposure to bitumen fume and other agents
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Boffetta, P., Burstyn, I., Partanen, T.J., Kromhout, H., Svane, O., Langard, S., Jarvholm, B., Frentzel-Beyme, R., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D.J.J., Ahrens, W., Bergdahl, I.A., Cenee, S., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B., Schill, W., Universiteit Utrecht, and Faculteit Diergeneeskunde
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asphalt ,coal tar ,technology, industry, and agriculture ,otorhinolaryngologic diseases ,Coronacrisis-Taverne ,epidemiology ,road paving ,lung neoplasms ,roofing ,complex mixtures ,mortality ,bitumen fume ,respiratory tract diseases - Abstract
Background An increased risk of lung cancers among asphalt workers has been suggested in epidemiological studies based on large scale statistical analyses. Methods In a multi‐country study of 29,820 male workers employed in road paving, asphalt mixing and roofing, 32,245 ground and building construction workers and 17,757 other workers from Denmark, Finland, France, Germany, Israel, the Netherlands, Norway, and Sweden, with mortality that was documented from 1953–2000. Exposures to bitumen fume, coal tar, 4–6 ring polycyclic aromatic hydrocarbons, organic vapor, diesel exhaust, asbestos, and silica dust were assessed via a job‐exposure matrix. Standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) based on national mortality rates, as well as relative risks (RRs) based on Poisson regression models were calculated. Results The SMR of lung cancer among workers exposed to bitumen fume (1.08, 95% CI 0.99–1.18) was comparable to that of non‐exposed workers (SMR 1.05, 95% CI 0.92–1.19). In a sub‐cohort of bitumen‐exposed workers without exposure to coal tar, the SMR of lung cancer was 1.23 (95% CI 1.02–1.48). The analysis based on the semi‐quantitative, matrix‐based exposures in the whole cohort did not suggest an increased lung cancer risk following exposure to bitumen fume. However, in an analysis restricted to road pavers, based on quantitative estimate of bitumen fume exposure, a dose‐response was suggested for average level of exposure, applying a 15‐year lag, which was marginally reduced after adjustment for co‐exposure to coal tar. The results for cancer of the head and neck were similar to those of lung cancer, although they were based on a smaller number of deaths. There was no clear suggestion of an association with bitumen fume for any other neoplasm. Conclusions The results of the analysis by bitumen fume exposure do not allow us to conclude on the presence or absence of a causal link between exposure to bitumen fume and risk of cancer of the lung and the head and neck. Am. J. Ind. Med. 43:28–39, 2003. © 2003 Wiley‐Liss, Inc.
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- 2003
18. Estimating exposures in the asphalt industry for an international epidemiological cohort study of cancer risk
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Burstyn, I., Boffetta, P., Kauppinen, T., Heikkila, P., Svane, O., Partanen, T.J., Stucker, I., Frentzel-Beyme, R., Ahrens, W., Merzenich, H., Heederik, D.J.J., Hooiveld, M., Langard, S., Randem, B., Jarvholm, B., Bergdahl, I.A., Shaham, J., Ribak, J., Kromhout, H., Universiteit Utrecht, and Faculteit Diergeneeskunde
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exposure matrix ,otorhinolaryngologic diseases ,technology, industry, and agriculture ,Coronacrisis-Taverne ,tar ,complex mixtures ,bitumen - Abstract
Background An exposure matrix (EM) for known and suspected carcinogens was required for a multicenter international cohort study of cancer risk and bitumen among asphalt workers. Methods Production characteristics in companies enrolled in the study were ascertained through use of a company questionnaire (CQ). Exposures to coal tar, bitumen fume, organic vapor, polycyclic aromatic hydrocarbons, diesel fume, silica, and asbestos were assessed semi‐quantitatively using information from CQs, expert judgment, and statistical models. Exposures of road paving workers to bitumen fume, organic vapor, and benzo(a)pyrene were estimated quantitatively by applying regression models, based on monitoring data, to exposure scenarios identified by the CQs. Results Exposures estimates were derived for 217 companies enrolled in the cohort, plus the Swedish asphalt paving industry in general. Most companies were engaged in road paving and asphalt mixing, but some also participated in general construction and roofing. Coal tar use was most common in Denmark and The Netherlands, but the practice is now obsolete. Quantitative estimates of exposure to bitumen fume, organic vapor, and benzo(a)pyrene for pavers, and semi‐quantitative estimates of exposure to these agents among all subjects were strongly correlated. Semi‐quantitative estimates of exposure to bitumen fume and coal tar exposures were only moderately correlated. EM assessed non‐monotonic historical decrease in exposures to all agents assessed except silica and diesel exhaust. Conclusions We produced a data‐driven EM using methodology that can be adapted for other multicenter studies. Am. J. Ind. Med. 43:3–17, 2003. © 2003 Wiley‐Liss, Inc.
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- 2003
19. Cancer mortality among European asphalt workers: An international epidemiological study. I. Results of the analysis based on job titles
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Boffetta, P., Burstyn, I., Partanen, T.J., Kromhout, H., Svane, O., Langard, S., Jarvholm, B., Frentzel-Beyme, R., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D.J.J., Ahrens, W., Bergdahl, I.A., Cenee, S., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B., Schill, W., Universiteit Utrecht, and Faculteit Diergeneeskunde
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asphalt ,Coronacrisis-Taverne ,epidemiology ,road paving ,occupational exposures ,lung neoplasms ,roofing ,mortality - Abstract
Background Inhalation of bitumen fumes is potentially carcinogenic to humans. Methods We conducted a study of 29,820 male workers exposed to bitumen in road paving, asphalt mixing and roofing, 32,245 ground and building construction workers unexposed to bitumen, and 17,757 workers not classifiable as bitumen workers, from Denmark, Finland, France, Germany, Israel, the Netherlands, Norway, and Sweden, with mortality follow‐up during 1953–2000. We calculated standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) based on national mortality rates. Poisson regression analyses compared mortality of bitumen workers to that of building or ground construction workers. Results The overall mortality was below expectation in the total cohort (SMR 0.92, 95% CI 0.90–0.94) and in each group of workers. The SMR of lung cancer was higher among bitumen workers (1.17, 95% CI 1.04–1.30) than among workers in ground and building construction (SMR 1.01, 95% CI 0.89–1.15). In the internal comparison, the relative risk (RR) of lung cancer mortality among bitumen workers was 1.09 (95% CI 0.89–1.34). The results of cancer of the head and neck were similar to those of lung cancer, based on a smaller number of deaths. There was no suggestion of an association between employment in bitumen jobs and other cancers. Conclusions European workers employed in road paving, asphalt mixing and other jobs entailing exposure to bitumen fume might have experienced a small increase in lung cancer mortality risk, compared to workers in ground and building construction. However, exposure assessment was limited and confounding from exposure to carcinogens in other industries, tobacco smoking, and other lifestyle factors cannot be ruled out. Am. J. Ind. Med. 43:18–27, 2003. © 2003 Wiley‐Liss, Inc.
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- 2003
20. Performance of different exposure assessment approaches in a study of bitumen fume exposure and lung cancer mortality
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Burstyn, I., Boffetta, P., Kauppinen, T., Heikkila, P., Svane, O., Partanen, T.J., Stucker, I., Frentzel-Beyme, R., Ahrens, W., Merzenich, H., Heederik, D.J.J., Hooiveld, M., Brunekreef, B., Langard, S., Randem, B., Jarvholm, B., Bergdahl, I.A., Shaham, J., Ferro, G., Kromhout, H., Universiteit Utrecht, and Faculteit Diergeneeskunde
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exposure reconstruction methodology ,model fit ,quantitative exposure assessment ,cohort study ,Coronacrisis-Taverne ,respiratory tract diseases - Abstract
Background We compared performance of different exposure assessment approaches in a cohort study of cancer risk among European asphalt workers. Methods Three bitumen fume exposure indices (duration of exposure (years), average exposure (mg/m3) and cumulative exposure (mg/m3*years)) and two latency models (with and without a 15 year lag) were considered for an association between lung cancer mortality and bitumen fume. Results There was no association between lung cancer risk and either duration or cumulative exposure. However, there was the suggestion of an increase in lung cancer risk accompanying rise in average exposure. Only models with average bitumen fume exposure (with or without lag) improved model fit, albeit to the same extent. Conclusions Constructing quantitative indices of exposure intensity was justified because they produced the greatest improvement in fit of models that explored possible relationship between bitumen fume exposure and lung cancer risk. The identified associations require further investigation. Am. J. Ind. Med. 43:40–48, 2003. © 2003 Wiley‐Liss, Inc.
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- 2003
21. Mortality from obstructive lung diseases and exposure to polycyclic aromatic hydrocarbons among asphalt workers
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Burstyn, I., Boffetta, P., Heederik, D.J.J., Partanen, T.J., Kromhout, H., Svane, O., Langard, S., Frentzel-Beyme, R., Kauppinen, T., Stucker, I., Shaham, J., Ahrens, W., Cenee, S., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B., Schill, W., Universiteit Utrecht, Faculteit Diergeneeskunde, Secretariat, U754, Division of Occupational and Environmental Health, Institute for Risk Assessment (IRAS), Utrecht University [Utrecht], Unit of Environment Cancer Epidemiology, IARC, Unit of Excellence for Psychosocial Factors, Finnish Institute of Occupational Health, Danish Working Environment Service, Centre for Occupational and Environmental Medicine, Riskhospitalet University Hospital, Bremen Institute for Prevention Research and Social Medicine, Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Occupational Cancer Department, National Institute of Occupational and Environmental Health, Institute of Cancer Epidemiology, Danish Cancer Society, Universiteit Utrecht, and Faculteit Diergeneeskunde
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Male ,Chronic bronchitis ,Pathology ,Epidemiology ,Abbreviations: ICD-9 ,MESH: Risk Assessment ,MESH: Occupational Exposure ,Cohort Studies ,Ninth Revision ,chemistry.chemical_compound ,Road Construction Workers’ Exposure Matrix ,Determinants in Health and Disease [EBP 1] ,Israel ,Polycyclic Aromatic Hydrocarbons ,MESH: Cohort Studies ,Coal Tar ,Inhalation Exposure ,MESH: Time ,Respiratory disease ,MESH: Israel ,MESH: Follow-Up Studies ,Polycyclic aromatic hydrocarbon ,Causality ,Europe ,Occupational Diseases ,Benzo(a)pyrene ,Bronchitis ,MESH: Inhalation Exposure ,ICD-9 ,medicine.drug ,MESH: Occupational Diseases ,medicine.medical_specialty ,Coronacrisis-Taverne ,MESH: Coal Tar ,MESH: Causality ,Risk Assessment ,ICD-9 [Abbreviations] ,Time ,Occupational medicine ,MESH: Polycyclic Hydrocarbons, Aromatic ,International Classification of Diseases ,Interventional oncology [UMCN 1.5] ,Occupational Exposure ,Environmental health ,polycyclic aromatic hydrocarbon ,MESH: Hydrocarbons ,MESH: Lung Diseases, Obstructive ,medicine ,Humans ,Lung Diseases, Obstructive ,Coal tar ,Asthma ,MESH: Humans ,business.industry ,PAH ,medicine.disease ,Hydrocarbons ,MESH: Male ,respiratory tract diseases ,ROCEM ,chemistry ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,MESH: Europe ,business ,Aromatic ,Follow-Up Studies - Abstract
Item does not contain fulltext Work in the asphalt industry has been associated with nonmalignant respiratory morbidity and mortality, but the evidence is not consistent. A historical cohort of asphalt workers included 58,862 men (911,209 person-years) first employed between 1913 and 1999 in companies applying and mixing asphalt in Denmark, Finland, France, Germany, Israel, the Netherlands, and Norway. The relations between mortality from nonmalignant respiratory diseases (including the obstructive lung diseases: chronic bronchitis, emphysema, and asthma) and specific chemical agents and mixtures were evaluated using a study-specific exposure matrix. Mortality from obstructive lung diseases was associated with the estimated cumulative and average exposures to polycyclic aromatic hydrocarbons and coal tar (p values of the test for linear trend = 0.06 and 0.01, respectively). The positive association between bitumen fume exposure and mortality from obstructive lung diseases was weak and not statistically significant; confounding by simultaneous exposure to coal tar could not be excluded. The authors lacked data on smoking and full occupational histories. In conclusion, exposures to polycyclic aromatic hydrocarbons, originating from coal tar and possibly from bitumen fume, may have contributed to mortality from obstructive lung diseases among asphalt workers, but confounding and bias cannot be ruled out as an explanation for the observed associations.
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- 2003
22. Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium
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Leoncini, Emanuele, Ricciardi, Walter, Cadoni, Gabriella, Arzani, Dario, Petrelli, Livia, Paludetti, Gaetano, Brennan, P, Luce, D, Stucker, I, Matsuo, K, Talamini, R, La Vecchia, C, Olshan, Af, Winn, Dm, Herrero, R, Franceschi, S, Castellsague, X, Muscat, J, Morgenstern, H, Zhang, Z, Levi, F, Dal Maso, L, Kelsey, K, Mcclean, M, Vaughan, Tl, Lazarus, P, Purdue, Mp, Hayes, Rb, Chen, C, Schwartz, Sm, Shangina, O, Koifman, S, Ahrens, W, Matos, E, Lagiou, P, Lissowska, J, Szeszenia Dabrowska, N, Fernandez, L, Menezes, A, Agudo, A, Daudt, Aw, Richiardi, L, Kjaerheim, K, Mates, D, Betka, J, Yu, G, Schantz, S, Simonato, L, Brenner, H, Conway, Di, Macfarlane, Tv, Thomson, P, Fabianova, E, Znaor, A, Rudnai, P, Healy, C, Boffetta, P, Chuang, S, Lee, Ya, Hashibe, M, Boccia, Stefania, Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), Boccia, Stefania (ORCID:0000-0002-1864-749X), Leoncini, Emanuele, Ricciardi, Walter, Cadoni, Gabriella, Arzani, Dario, Petrelli, Livia, Paludetti, Gaetano, Brennan, P, Luce, D, Stucker, I, Matsuo, K, Talamini, R, La Vecchia, C, Olshan, Af, Winn, Dm, Herrero, R, Franceschi, S, Castellsague, X, Muscat, J, Morgenstern, H, Zhang, Z, Levi, F, Dal Maso, L, Kelsey, K, Mcclean, M, Vaughan, Tl, Lazarus, P, Purdue, Mp, Hayes, Rb, Chen, C, Schwartz, Sm, Shangina, O, Koifman, S, Ahrens, W, Matos, E, Lagiou, P, Lissowska, J, Szeszenia Dabrowska, N, Fernandez, L, Menezes, A, Agudo, A, Daudt, Aw, Richiardi, L, Kjaerheim, K, Mates, D, Betka, J, Yu, G, Schantz, S, Simonato, L, Brenner, H, Conway, Di, Macfarlane, Tv, Thomson, P, Fabianova, E, Znaor, A, Rudnai, P, Healy, C, Boffetta, P, Chuang, S, Lee, Ya, Hashibe, M, Boccia, Stefania, Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), and Boccia, Stefania (ORCID:0000-0002-1864-749X)
- Abstract
Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95 % CI 0.86-0.95 for men; adjusted OR = 0.86, 95 % CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.
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- 2013
23. Estimating exposures in the asphalt industry for an international epidemiological cohort study of cancer risk
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Burstyn, I., Boffetta, P., Kauppinen, T., Heikkila, P., Svane, O., Partanen, T.A., Stucker, I., Frentzel-Beyme, R., Ahrens, W., Merzenich, H., Heederik, D.J.J., Hooiveld, M., Langard, S., Randem, B.G., Jarvholm, B., Bergdahl, I.A., Shaham, J., Ribak, J., Kromhout, H., Division of Occupational and Environmental Health, Institute for Risk Assessment (IRAS), Utrecht University [Utrecht], Unit of Environment Cancer Epidemiology, IARC, Unit of Excellence for Psychosocial Factors, Finnish Institute of Occupational Health, Danish Working Environment Service, Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Bremen Institute for Prevention Research and Social Medicine, Centre for Occupational and Environmental Medicine, Riskhospitalet University Hospital, Occupational Medicine, Department of Public Health and Clinical Medicine, Umea University Hospital, Occupational Cancer Department, National Institute of Occupational and Environmental Health, Secretariat, U754, Universiteit Utrecht, and Faculteit Diergeneeskunde
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Coronacrisis-Taverne ,MESH: Epidemiologic Methods ,MESH: Risk Assessment ,complex mixtures ,Risk Assessment ,MESH: Occupational Exposure ,Cohort Studies ,exposure matrix ,Interventional oncology [UMCN 1.5] ,Occupational Exposure ,MESH: Hydrocarbons ,Determinants in Health and Disease [EBP 1] ,otorhinolaryngologic diseases ,Humans ,Multicenter Studies as Topic ,tar ,Israel ,MESH: Cohort Studies ,bitumen ,Inhalation Exposure ,MESH: Humans ,Models, Statistical ,MESH: Israel ,technology, industry, and agriculture ,Hydrocarbons ,respiratory tract diseases ,Europe ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,MESH: Multicenter Studies as Topic ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,MESH: Europe ,MESH: Inhalation Exposure ,Epidemiologic Methods ,MESH: Models, Statistical - Abstract
Background An exposure matrix (EM) for known and suspected carcinogens was required for a multicenter international cohort study of cancer risk and bitumen among asphalt workers. Methods Production characteristics in companies enrolled in the study were ascertained through use of a company questionnaire (CQ). Exposures to coal tar, bitumen fume, organic vapor, polycyclic aromatic hydrocarbons, diesel fume, silica, and asbestos were assessed semi‐quantitatively using information from CQs, expert judgment, and statistical models. Exposures of road paving workers to bitumen fume, organic vapor, and benzo(a)pyrene were estimated quantitatively by applying regression models, based on monitoring data, to exposure scenarios identified by the CQs. Results Exposures estimates were derived for 217 companies enrolled in the cohort, plus the Swedish asphalt paving industry in general. Most companies were engaged in road paving and asphalt mixing, but some also participated in general construction and roofing. Coal tar use was most common in Denmark and The Netherlands, but the practice is now obsolete. Quantitative estimates of exposure to bitumen fume, organic vapor, and benzo(a)pyrene for pavers, and semi‐quantitative estimates of exposure to these agents among all subjects were strongly correlated. Semi‐quantitative estimates of exposure to bitumen fume and coal tar exposures were only moderately correlated. EM assessed non‐monotonic historical decrease in exposures to all agents assessed except silica and diesel exhaust. Conclusions We produced a data‐driven EM using methodology that can be adapted for other multicenter studies. Am. J. Ind. Med. 43:3–17, 2003. © 2003 Wiley‐Liss, Inc.
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- 2002
24. Metabolic gene polymorphism frequencies in control populations
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Garte, S., Gaspari, L., Alexandrie, A. K., Ambrosone, C., Autrup, H., Autrup, J. L., Baranova, H., Bathum, L., Benhamou, S., Boffetta, P., Bouchardy, C., Breskvar, K., Brockmoller, J., Cascorbi, I., Clapper, M. L., Coutelle, C., Daly, A., Omo, M., Dolzan, V., Dresler, C. M., Fryer, A., Haugen, A., Hein, D. W., Hildesheim, A., Hirvonen, A., Hsieh, L. L., Ingelman-Sundberg, M., Kalina, I., Kang, D., Kihara, M., Kiyohara, C., Kremers, P., Lazarus, P., Le Marchand, L., Lechner, M. C., Lieshout, E. M., Stephanie London, Manni, J. J., Maugard, C. M., Morita, S., Nazar-Stewart, V., Noda, K., Oda, Y., Parl, F. F., Pastorelli, R., Persson, I., Peters, W. H., Rannug, A., Rebbeck, T., Risch, A., Roelandt, L., Romkes, M., Ryberg, D., Salagovic, J., Schoket, B., Seidegard, J., Shields, P. G., Sim, E., Sinnet, D., Strange, R. C., Stucker, I., Sugimura, H., To-Figueras, J., Vineis, P., Yu, M. C., and Taioli, E.
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Polymorphism, Genetic ,Metabole aspecten van maag-, darm- en leveraandoeningen ,Cytochrome P-450 Enzyme System ,Databases, Factual ,Gene Frequency ,Genetic Linkage ,Neoplasms ,Black People ,Humans ,Metabolic aspects of gastrointestinal diseases ,Genetic Predisposition to Disease ,White People - Abstract
Item does not contain fulltext Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined. Major and significant differences in these frequencies were observed between Caucasians (n = 12,525), Asians (n = 2,136), and Africans and African Americans (n = 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.
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- 2001
25. Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium.
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Cote, M.L., Liu, M., Bonassi, S., Neri, M., Schwartz, A.G., Christiani, D.C., Spitz, M.R., Muscat, J.E., Rennert, G., Aben, K.K.H., Andrew, A.S., Bencko, V., Bickeboller, H., Boffetta, P., Brennan, P., Brenner, H., Duell, E.J., Fabianova, E., Field, J.K., Foretova, L., Friis, S., Harris, C.C., Holcatova, I., Hong, Y.C., Isla, D., Janout, V., Kiemeney, L.A.L.M., Kiyohara, C., Lan, Q., Lazarus, P., Lissowska, J., Marchand, L. le, Mates, D., Matsuo, K., Mayordomo, J.I., McLaughlin, J.R., Morgenstern, H., Mueller, H., Orlow, I., Park, B.J., Pinchev, M., Raji, O.Y., Rennert, H.S., Rudnai, P., Seow, A., Stucker, I., Szeszenia-Dabrowska, N., Teare, M.D., Tjonnelan, A., Ugolini, D., Heijden, E. van der, Wichmann, E., Wiencke, J.K., Woll, P.J., Yang, P., Zaridze, D., Zhang, Z.F., Etzel, C.J., Hung, R.J., Cote, M.L., Liu, M., Bonassi, S., Neri, M., Schwartz, A.G., Christiani, D.C., Spitz, M.R., Muscat, J.E., Rennert, G., Aben, K.K.H., Andrew, A.S., Bencko, V., Bickeboller, H., Boffetta, P., Brennan, P., Brenner, H., Duell, E.J., Fabianova, E., Field, J.K., Foretova, L., Friis, S., Harris, C.C., Holcatova, I., Hong, Y.C., Isla, D., Janout, V., Kiemeney, L.A.L.M., Kiyohara, C., Lan, Q., Lazarus, P., Lissowska, J., Marchand, L. le, Mates, D., Matsuo, K., Mayordomo, J.I., McLaughlin, J.R., Morgenstern, H., Mueller, H., Orlow, I., Park, B.J., Pinchev, M., Raji, O.Y., Rennert, H.S., Rudnai, P., Seow, A., Stucker, I., Szeszenia-Dabrowska, N., Teare, M.D., Tjonnelan, A., Ugolini, D., Heijden, E. van der, Wichmann, E., Wiencke, J.K., Woll, P.J., Yang, P., Zaridze, D., Zhang, Z.F., Etzel, C.J., and Hung, R.J.
- Abstract
1 september 2012, Item does not contain fulltext, BACKGROUND AND METHODS: Familial aggregation of lung cancer exists after accounting for cigarette smoking. However, the extent to which family history affects risk by smoking status, histology, relative type and ethnicity is not well described. This pooled analysis included 24 case-control studies in the International Lung Cancer Consortium. Each study collected age of onset/interview, gender, race/ethnicity, cigarette smoking, histology and first-degree family history of lung cancer. Data from 24,380 lung cancer cases and 23,305 healthy controls were analysed. Unconditional logistic regression models and generalised estimating equations were used to estimate odds ratios and 95% confidence intervals. RESULTS: Individuals with a first-degree relative with lung cancer had a 1.51-fold increase in the risk of lung cancer, after adjustment for smoking and other potential confounders (95% CI: 1.39, 1.63). The association was strongest for those with a family history in a sibling, after adjustment (odds ratios (OR)=1.82, 95% CI: 1.62, 2.05). No modifying effect by histologic type was found. Never smokers showed a lower association with positive familial history of lung cancer (OR=1.25, 95% CI: 1.03, 1.52), slightly stronger for those with an affected sibling (OR=1.44, 95% CI: 1.07, 1.93), after adjustment. CONCLUSIONS: The occurrence of lung cancer among never smokers and similar magnitudes of the effect of family history on lung cancer risk across histological types suggests familial aggregation of lung cancer is independent of those risks associated with cigarette smoking. While the role of genetic variation in the aetiology of lung cancer remains to be fully characterised, family history assessment is immediately available and those with a positive history represent a higher risk group.
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- 2012
26. Occupational exposure to organic dust increases lung cancer risk in the general population.
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Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Peters, S., Kromhout, H., Olsson, A.C., Wichmann, H.E., Bruske, I., Consonni, D., Landi, M.T., Caporaso, N., Siemiatycki, J., Richiardi, L., Mirabelli, D., Simonato, L., Gustavsson, P., Plato, N., Jockel, K.H., Ahrens, W., Pohlabeln, H., Boffetta, P., Brennan, P., Zaridze, D., Cassidy, A., Lissowska, J, Szeszenia-Dabrowska, N., Rudnai, P., Fabianova, E., Forastiere, F., Bencko, V., Foretova, L., Janout, V., Stucker, I., Dumitru, R.S., Benhamou, S., Bueno-de-Mesquita, B., Kendzia, B., Pesch, B., Straif, K., Bruning, T., Vermeulen, R., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Peters, S., Kromhout, H., Olsson, A.C., Wichmann, H.E., Bruske, I., Consonni, D., Landi, M.T., Caporaso, N., Siemiatycki, J., Richiardi, L., Mirabelli, D., Simonato, L., Gustavsson, P., Plato, N., Jockel, K.H., Ahrens, W., Pohlabeln, H., Boffetta, P., Brennan, P., Zaridze, D., Cassidy, A., Lissowska, J, Szeszenia-Dabrowska, N., Rudnai, P., Fabianova, E., Forastiere, F., Bencko, V., Foretova, L., Janout, V., Stucker, I., Dumitru, R.S., Benhamou, S., Bueno-de-Mesquita, B., Kendzia, B., Pesch, B., Straif, K., Bruning, T., and Vermeulen, R.
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- 2012
27. A case-control study of lung cancer nested in a cohort of European asphalt workers.
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Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Olsson, A., Kromhout, H., Agostini, M., Hansen, J., Funch Lassen, C., Johansen, C., Kjaerheim, K., Langard, S., Stucker, I., Ahrens, W., Behrens, T., Lindbohm, M-J., Heikkila, P., Heederik, D., Portengen, L., Shaham, J., Ferro, G., de Vocht, F., Burstyn, I., Boffetta, P., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Olsson, A., Kromhout, H., Agostini, M., Hansen, J., Funch Lassen, C., Johansen, C., Kjaerheim, K., Langard, S., Stucker, I., Ahrens, W., Behrens, T., Lindbohm, M-J., Heikkila, P., Heederik, D., Portengen, L., Shaham, J., Ferro, G., de Vocht, F., Burstyn, I., and Boffetta, P.
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- 2010
28. Exposure assessment for a nested case-control study of lung cancer among European asphalt workers.
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Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Agostini, M., Ferro, G., Olsson, A., Burstyn, I., de Vocht, F., Hansen, J., Funch Lassen, C., Johansen, C., Kjaerheim, K., Langard, S., Stucker, I., Ahrens, W., Behrens, T., Lindbohm, M-J., Heikkila, P., Heederik, D., Portengen, L., Shaham, J., Boffetta, P., Kromhout, H., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Agostini, M., Ferro, G., Olsson, A., Burstyn, I., de Vocht, F., Hansen, J., Funch Lassen, C., Johansen, C., Kjaerheim, K., Langard, S., Stucker, I., Ahrens, W., Behrens, T., Lindbohm, M-J., Heikkila, P., Heederik, D., Portengen, L., Shaham, J., Boffetta, P., and Kromhout, H.
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- 2010
29. Lung Cancer Risk Among Hairdressers: A Pooled Analysis of Case-Control Studies Conducted Between 1985 and 2010
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Olsson, A. C., primary, Xu, Y., additional, Schuz, J., additional, Vlaanderen, J., additional, Kromhout, H., additional, Vermeulen, R., additional, Peters, S., additional, Stucker, I., additional, Guida, F., additional, Bruske, I., additional, Wichmann, H.-E., additional, Consonni, D., additional, Landi, M. T., additional, Caporaso, N., additional, Tse, L. A., additional, Yu, I. T.-s., additional, Siemiatycki, J., additional, Richardson, L., additional, Mirabelli, D., additional, Richiardi, L., additional, Simonato, L., additional, Gustavsson, P., additional, Plato, N., additional, Jockel, K.-H., additional, Ahrens, W., additional, Pohlabeln, H., additional, Tardon, A., additional, Zaridze, D., additional, Marcus, M. W., additional, 't Mannetje, A., additional, Pearce, N., additional, McLaughlin, J., additional, Demers, P., additional, Szeszenia-Dabrowska, N., additional, Lissowska, J., additional, Rudnai, P., additional, Fabianova, E., additional, Dumitru, R. S., additional, Bencko, V., additional, Foretova, L., additional, Janout, V., additional, Boffetta, P., additional, Fortes, C., additional, Bueno-de-Mesquita, B., additional, Kendzia, B., additional, Behrens, T., additional, Pesch, B., additional, Bruning, T., additional, and Straif, K., additional
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- 2013
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30. Hormone use and risk for lung cancer: a pooled analysis from the International Lung Cancer Consortium (ILCCO)
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Pesatori, A C, primary, Carugno, M, additional, Consonni, D, additional, Hung, R J, additional, Papadoupolos, A, additional, Landi, M T, additional, Brenner, H, additional, Müller, H, additional, Harris, C C, additional, Duell, E J, additional, Andrew, A S, additional, McLaughlin, J R, additional, Schwartz, A G, additional, Wenzlaff, A S, additional, and Stucker, I, additional
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- 2013
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31. Polycyclic aromatic hydrocarbons and fatal ischemic heart disease
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Faculteit Diergeneeskunde, Burstyn, I., Kromhout, H., Partanen, T.J., Svane, O., Langard, S., Ahrens, W., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D.J.J., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B., Boffetta, P., Faculteit Diergeneeskunde, Burstyn, I., Kromhout, H., Partanen, T.J., Svane, O., Langard, S., Ahrens, W., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D.J.J., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B., and Boffetta, P.
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- 2005
32. Association of metabolic gene polymorphisms with tobacco consumption in healthy controls.
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Smits, K.M., Benhamou, S., Garte, S., Weijenberg, M.P., Alamanos, Y., Ambrosone, C., Autrup, H., Autrup, J.L., Baranova, H., Bathum, L., Boffetta, P., Bouchardy, C., Brockmoller, J., Butkiewicz, D., Cascorbi, I., Clapper, M.L., Coutelle, C., Daly, A., Muzi, G., Dolzan, V., Duzhak, T.G., Farker, K., Golka, K., Haugen, A., Hein, D.W., Hildesheim, A., Hirvonen, A., Hsieh, L.L., Ingelman-Sundberg, M., Kalina, I., Kang, D., Katoh, T., Kihara, M., Ono-Kihara, M., Kim, H.L., Kiyohara, C., Kremers, P., Lazarus, P., Marchand, L. le, Lechner, M.C., London, S., Manni, J.J., Maugard, C.M., Morgan, G.J., Morita, S., Nazar-Stewart, V., Kristensen, V.N., Oda, Y., Parl, F.F., Peters, W.H.M., Rannug, A., Rebbeck, T.R., Pinto, L.F., Risch, A., Romkes, M., Salagovic, J., Schoket, B., Seidegard, J., Shields, P.G., Sim, E., Sinnett, D., Strange, R.C., Stucker, I., Sugimura, H., To-Figueras, J., Vineis, P., Yu, M.C., Zheng, W., Pedotti, P., Taioli, E., Smits, K.M., Benhamou, S., Garte, S., Weijenberg, M.P., Alamanos, Y., Ambrosone, C., Autrup, H., Autrup, J.L., Baranova, H., Bathum, L., Boffetta, P., Bouchardy, C., Brockmoller, J., Butkiewicz, D., Cascorbi, I., Clapper, M.L., Coutelle, C., Daly, A., Muzi, G., Dolzan, V., Duzhak, T.G., Farker, K., Golka, K., Haugen, A., Hein, D.W., Hildesheim, A., Hirvonen, A., Hsieh, L.L., Ingelman-Sundberg, M., Kalina, I., Kang, D., Katoh, T., Kihara, M., Ono-Kihara, M., Kim, H.L., Kiyohara, C., Kremers, P., Lazarus, P., Marchand, L. le, Lechner, M.C., London, S., Manni, J.J., Maugard, C.M., Morgan, G.J., Morita, S., Nazar-Stewart, V., Kristensen, V.N., Oda, Y., Parl, F.F., Peters, W.H.M., Rannug, A., Rebbeck, T.R., Pinto, L.F., Risch, A., Romkes, M., Salagovic, J., Schoket, B., Seidegard, J., Shields, P.G., Sim, E., Sinnett, D., Strange, R.C., Stucker, I., Sugimura, H., To-Figueras, J., Vineis, P., Yu, M.C., Zheng, W., Pedotti, P., and Taioli, E.
- Abstract
Contains fulltext : 58545.pdf (publisher's version ) (Closed access), Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYP1A1, GSTM1, GSTT1, NAT2 and GSTP1. None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected.
- Published
- 2004
33. Risk of fatal industrial accidents and death from other external causes among asphalt workers
- Author
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Universiteit Utrecht, Faculteit Diergeneeskunde, Burstyn, I., Boffetta, P., Jarvholm, B., Partanen, T.J., Svane, O., Langard, S., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D.J.J., Ahrens, W., Bergdahl, I.A., Cenée, S., Hooiveld, M., Randem, B., Johansen, C., Ferro, G., Kromhout, H., Universiteit Utrecht, Faculteit Diergeneeskunde, Burstyn, I., Boffetta, P., Jarvholm, B., Partanen, T.J., Svane, O., Langard, S., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D.J.J., Ahrens, W., Bergdahl, I.A., Cenée, S., Hooiveld, M., Randem, B., Johansen, C., Ferro, G., and Kromhout, H.
- Published
- 2004
34. Lung cancer risk in painters: results from the SYNERGY pooled analysis
- Author
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Guha, N., primary, Olsson, A., additional, Kromhout, H., additional, Vermeulen, R., additional, Bruning, T., additional, Pesch, B., additional, Kendzia, B., additional, Wichmann, H.-E., additional, Bruske, I., additional, Stucker, I., additional, De Matteis, S., additional, Landi, M. T., additional, Caporaso, N., additional, Siemiatycki, J., additional, Gustavsson, P., additional, Plato, N., additional, Merletti, F., additional, Mirabelli, D., additional, Richiardi, L., additional, Ahrens, W., additional, Pohlabeln, H., additional, Jockel, K.-H., additional, Zaridze, D., additional, Cassidy, A., additional, Lissowska, J., additional, Szeszenia-Dabrowska, N., additional, Benhamou, S., additional, Slamova, A., additional, Foretova, L., additional, Janout, V., additional, Rudnai, P., additional, Fabianova, E., additional, Dumitru, R. S., additional, Forastiere, F., additional, Bueno-de-Mesquita, B., additional, Peters, S., additional, Boffetta, P., additional, Benhaim-Luzon, V., additional, and Straif, K., additional
- Published
- 2011
- Full Text
- View/download PDF
35. Lung cancer and exposure to mineral wools: the ICARE study
- Author
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Guida, F., primary, Lamkarkach, F., additional, Cenee, S., additional, Cyr, D., additional, Gaye, O., additional, Lacourt, A., additional, Brochard, P., additional, Ducamp, S., additional, Paris, C., additional, Fevotte, J., additional, Luce, D., additional, and Stucker, I., additional
- Published
- 2011
- Full Text
- View/download PDF
36. Occupation and head and neck cancer: a population-based case-control study in France
- Author
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Paget-Bailly, S., primary, Carton, M., additional, Guida, F., additional, Radoi, L., additional, Cyr, D., additional, Wanzy, K., additional, Schmaus, A., additional, Cenee, S., additional, Menvielle, G., additional, Papadopoulos, A., additional, Stucker, I., additional, and Luce, D., additional
- Published
- 2011
- Full Text
- View/download PDF
37. Lung cancer risk among cooks and kitchen workers in a pooled analysis of case-control studies in Europe and Canada
- Author
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Bigert, C., primary, Olsson, A., additional, Gustavsson, P., additional, Bruning, T., additional, Kendzia, B., additional, Pesch, B., additional, Jockel, K.-H., additional, Pohlabeln, H., additional, Ahrens, W., additional, Gross, I., additional, Bruske, I., additional, Wichmann, H.-E., additional, Merletti, F., additional, Mirabelli, D., additional, Richiardi, L., additional, Zaridze, D., additional, Cassidy, A., additional, Szeszenia-Dabrowska, N., additional, Rudnai, P., additional, Lissowska, J., additional, Stucker, I., additional, Fabianova, E., additional, Dumitru, R. S., additional, Bencko, V., additional, Foretova, L., additional, Janout, V., additional, Siemiatycki, J., additional, Landi, M. T., additional, Caporaso, N., additional, Brennan, P., additional, Benhamou, S., additional, Benhaim-Luzon, V., additional, Kromhout, H., additional, Vermeulen, R., additional, Peters, S., additional, Consonni, D., additional, Bueno-de-Mesquita, B., additional, Boffetta, P., additional, and Straif, K., additional
- Published
- 2011
- Full Text
- View/download PDF
38. Lung cancer risk among hairdressers in SYNERGY - pooled analysis from case-control studies in Europe and Canada
- Author
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Olsson, A., primary, Guha, N., additional, Bruning, T., additional, Pesch, B., additional, Kendzia, B., additional, Wichmann, H.-E., additional, Bruske, I., additional, Stucker, I., additional, Pesatori, A. C., additional, Landi, M. T., additional, Caporaso, N., additional, Siemiatycki, J., additional, Gustavsson, P., additional, Plato, N., additional, Merletti, F., additional, Mirabelli, D., additional, Richiardi, L., additional, Ahrens, W., additional, Pohlabeln, H., additional, Jockel, K.-H., additional, Zaridze, D., additional, Cassidy, A., additional, Lissowska, J., additional, Szeszenia-Dabrowska, N., additional, Benhamou, S., additional, Schejbalova, M., additional, Foretova, L., additional, Janout, V., additional, Rudnai, P., additional, Fabianova, E., additional, Dumitru, R. S., additional, Forastiere, F., additional, Bueno-de-Mesquita, B., additional, Benhaim-Luzon, V., additional, Peters, S., additional, Vermeulen, R., additional, Boffetta, P., additional, Kromhout, H., additional, and Straif, K., additional
- Published
- 2011
- Full Text
- View/download PDF
39. Exposure-response relation for occupational exposure to respirable quartz and lung cancer risk: performance of a quantitative vs a semi-quantitative job-exposure matrix
- Author
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Peters, S., primary, Vermeulen, R., additional, Portengen, L., additional, Olsson, A., additional, Wichmann, H.-E., additional, Bruske, I., additional, Consonni, D., additional, Cattaneo, A., additional, Bertazzi, P. A., additional, Siemiatycki, J., additional, Richiardi, L., additional, Mirabelli, D., additional, Simonato, L., additional, Gustavsson, P., additional, Jockel, K.-H., additional, Ahrens, W., additional, Pohlabeln, H., additional, Boffetta, P., additional, Brennan, P., additional, Forastiere, F., additional, Stucker, I., additional, Benhamou, S., additional, Bueno-de-Mesquita, B., additional, Plato, N., additional, Lavoue, J., additional, Dahmann, D., additional, Fevotte, J., additional, Kendzia, B., additional, Vincent, R., additional, Savary, B., additional, Cavallo, D., additional, Pesch, B., additional, Bruning, T., additional, Straif, K., additional, and Kromhout, H., additional
- Published
- 2011
- Full Text
- View/download PDF
40. Lung cancer risk among men by occupation and industry in SYNERGY - pooled analysis of case-control studies on the joint effects of occupational carcinogens in the development of lung cancer
- Author
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Mirabelli, D., primary, Merletti, F., additional, Richiardi, L., additional, Corbin, M., additional, Franch, I. M., additional, Olsson, A., additional, Gustavsson, P., additional, Kromhout, H., additional, Peters, S., additional, Vermeulen, R., additional, Bruske, I., additional, Pesch, B., additional, Bruning, T., additional, Gross, I., additional, Siemiatycki, J., additional, Pintos, J., additional, Wichmann, H.-E., additional, Consonni, D., additional, Plato, N., additional, Ahrens, W., additional, Pohlabeln, H., additional, Lissowska, J., additional, Szeszenia-Dabrowska, N., additional, Cassidy, A., additional, Zaridze, D., additional, Stucker, I., additional, Benhamou, S., additional, Bencko, V., additional, Foretova, L., additional, Janout, V., additional, Rudnai, P., additional, Fabianova, E., additional, Mates, D., additional, Bueno-de-Mesquita, B., additional, Boffetta, P., additional, and Straif, K., additional
- Published
- 2011
- Full Text
- View/download PDF
41. SYNERGY epidemiological database and some results on smoking by major histological subtypes of lung cancer
- Author
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Pesch, B., primary, Kendzia, B., additional, Gustavsson, P., additional, Jockel, K.-H., additional, Johnen, G., additional, Pohlabeln, H., additional, Olsson, A., additional, Ahrens, W., additional, Bruske, I., additional, Wichmann, H.-E., additional, Merletti, F., additional, Richiardi, L., additional, Simonato, L., additional, Fortes, C., additional, Siemiatycki, J., additional, Pintos, J., additional, Consonni, D., additional, Landi, M. T., additional, Caporaso, N., additional, Zaridze, D., additional, Cassidy, A., additional, Szeszenia-Dabrowska, N., additional, Rudnai, P., additional, Lissowska, J., additional, Stucker, I., additional, Fabianova, E., additional, Dumitru, R. S., additional, Bencko, V., additional, Foretova, L., additional, Janout, V., additional, McLaughlin, J., additional, Demers, P., additional, Peters, S., additional, Vermeulen, R., additional, Kromhout, H., additional, Bueno-de-Mesquita, B., additional, Brennan, P., additional, Boffetta, P., additional, Straif, K., additional, and Bruning, T., additional
- Published
- 2011
- Full Text
- View/download PDF
42. Occupational exposure to organic dust increases lung cancer risk in the general population
- Author
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Peters, S., primary, Kromhout, H., additional, Olsson, A., additional, Wuchmann, H.-E., additional, Bruske, I., additional, Consonni, D., additional, Landi, M. T., additional, Caporaso, N., additional, Siemiatycki, J., additional, Richiardi, L., additional, Mirabelli, D., additional, Simonato, L., additional, Gustavsson, P., additional, Plato, N., additional, Jockel, K.-H., additional, Ahrens, W., additional, Pohlabeln, H., additional, Boffetta, P., additional, Brennan, P., additional, Zaridze, D., additional, Cassidy, A., additional, Lissowska, J., additional, Szeszenia-Dabrowska, N., additional, Rudnai, P., additional, Fabianova, E., additional, Forastiere, F., additional, Bencko, V., additional, Foretova, L., additional, Janout, V., additional, Stucker, I., additional, Dumitru, R. S., additional, Benhamou, S., additional, Bueno-de-Mesquita, B., additional, Kendzia, B., additional, Pesch, B., additional, Straif, K., additional, Bruning, T., additional, and Vermeulen, R., additional
- Published
- 2011
- Full Text
- View/download PDF
43. Mortality from obstructive lung diseases and exposure to polycyclic aromatic hydrocarbons among asphalt workers
- Author
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Universiteit Utrecht, Faculteit Diergeneeskunde, Burstyn, I., Boffetta, P., Heederik, D.J.J., Partanen, T.J., Kromhout, H., Svane, O., Langard, S., Frentzel-Beyme, R., Kauppinen, T., Stucker, I., Shaham, J., Ahrens, W., Cenee, S., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B., Schill, W., Universiteit Utrecht, Faculteit Diergeneeskunde, Burstyn, I., Boffetta, P., Heederik, D.J.J., Partanen, T.J., Kromhout, H., Svane, O., Langard, S., Frentzel-Beyme, R., Kauppinen, T., Stucker, I., Shaham, J., Ahrens, W., Cenee, S., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B., and Schill, W.
- Published
- 2003
44. Cancer mortality among European asphalt workers: An international epidemiological study. II. Exposure to bitumen fume and other agents
- Author
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Universiteit Utrecht, Faculteit Diergeneeskunde, Boffetta, P., Burstyn, I., Partanen, T.J., Kromhout, H., Svane, O., Langard, S., Jarvholm, B., Frentzel-Beyme, R., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D.J.J., Ahrens, W., Bergdahl, I.A., Cenee, S., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B., Schill, W., Universiteit Utrecht, Faculteit Diergeneeskunde, Boffetta, P., Burstyn, I., Partanen, T.J., Kromhout, H., Svane, O., Langard, S., Jarvholm, B., Frentzel-Beyme, R., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D.J.J., Ahrens, W., Bergdahl, I.A., Cenee, S., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B., and Schill, W.
- Published
- 2003
45. Estimating exposures in the asphalt industry for an international epidemiological cohort study of cancer risk
- Author
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Universiteit Utrecht, Faculteit Diergeneeskunde, Burstyn, I., Boffetta, P., Kauppinen, T., Heikkila, P., Svane, O., Partanen, T.J., Stucker, I., Frentzel-Beyme, R., Ahrens, W., Merzenich, H., Heederik, D.J.J., Hooiveld, M., Langard, S., Randem, B., Jarvholm, B., Bergdahl, I.A., Shaham, J., Ribak, J., Kromhout, H., Universiteit Utrecht, Faculteit Diergeneeskunde, Burstyn, I., Boffetta, P., Kauppinen, T., Heikkila, P., Svane, O., Partanen, T.J., Stucker, I., Frentzel-Beyme, R., Ahrens, W., Merzenich, H., Heederik, D.J.J., Hooiveld, M., Langard, S., Randem, B., Jarvholm, B., Bergdahl, I.A., Shaham, J., Ribak, J., and Kromhout, H.
- Published
- 2003
46. Performance of different exposure assessment approaches in a study of bitumen fume exposure and lung cancer mortality
- Author
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Universiteit Utrecht, Faculteit Diergeneeskunde, Burstyn, I., Boffetta, P., Kauppinen, T., Heikkila, P., Svane, O., Partanen, T.J., Stucker, I., Frentzel-Beyme, R., Ahrens, W., Merzenich, H., Heederik, D.J.J., Hooiveld, M., Brunekreef, B., Langard, S., Randem, B., Jarvholm, B., Bergdahl, I.A., Shaham, J., Ferro, G., Kromhout, H., Universiteit Utrecht, Faculteit Diergeneeskunde, Burstyn, I., Boffetta, P., Kauppinen, T., Heikkila, P., Svane, O., Partanen, T.J., Stucker, I., Frentzel-Beyme, R., Ahrens, W., Merzenich, H., Heederik, D.J.J., Hooiveld, M., Brunekreef, B., Langard, S., Randem, B., Jarvholm, B., Bergdahl, I.A., Shaham, J., Ferro, G., and Kromhout, H.
- Published
- 2003
47. Cancer mortality among European asphalt workers: An international epidemiological study. I. Results of the analysis based on job titles
- Author
-
Universiteit Utrecht, Faculteit Diergeneeskunde, Boffetta, P., Burstyn, I., Partanen, T.J., Kromhout, H., Svane, O., Langard, S., Jarvholm, B., Frentzel-Beyme, R., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D.J.J., Ahrens, W., Bergdahl, I.A., Cenee, S., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B., Schill, W., Universiteit Utrecht, Faculteit Diergeneeskunde, Boffetta, P., Burstyn, I., Partanen, T.J., Kromhout, H., Svane, O., Langard, S., Jarvholm, B., Frentzel-Beyme, R., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D.J.J., Ahrens, W., Bergdahl, I.A., Cenee, S., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B., and Schill, W.
- Published
- 2003
48. Home and workplace smoking bans in Italy, Ireland, Sweden, France and the Czech Republic
- Author
-
Heck, J. E., primary, Stucker, I., additional, Allwright, S., additional, Gritz, E. R., additional, Haglund, M., additional, Healton, C. G., additional, Kralikova, E., additional, Sanchez Del Mazo, S., additional, Tamang, E., additional, Dresler, C. M., additional, and Hashibe, M., additional
- Published
- 2009
- Full Text
- View/download PDF
49. Meta- and Pooled Analysis of GSTT1 and Lung Cancer: A HuGE-GSEC Review
- Author
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Raimondi, S, primary, Paracchini, V, additional, Autrup, H, additional, Barros-Dios, J., additional, Benhamou, S, additional, Boffetta, P, additional, Cote, M., additional, Dialyna, I., additional, Dolzan, V, additional, Filiberti, R, additional, Garte, S, additional, Hirvonen, A, additional, Husgafvel-Pursiainen, K, additional, Imyanitov, E., additional, Kalina, I, additional, Kang, D, additional, Kiyohara, C, additional, Kohno, T, additional, Kremers, P, additional, Lan, Q, additional, London, S, additional, Povey, A., additional, Rannug, A, additional, Reszka, E, additional, Risch, A, additional, Romkes, M, additional, Schneider, J, additional, Seow, A, additional, Shields, P., additional, Sobti, R., additional, Sorensen, M, additional, Spinola, M, additional, Spitz, M., additional, Strange, R., additional, Stucker, I, additional, Sugimura, H, additional, To-Figueras, J, additional, Tokudome, S, additional, Yang, P, additional, Yuan, J-M, additional, Warholm, M, additional, and Taioli, E, additional
- Published
- 2006
- Full Text
- View/download PDF
50. Age and gender differences in the association between MPO 463>A and lung cancer. Results from the genetic susceptibility to environmental carcinogens pooled analysis
- Author
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Frullanti, E., primary, Forti, S., additional, Raimondi, S., additional, Benhamou, S., additional, Cascorbi, I., additional, Marchand, L. Le, additional, London, S.J., additional, Risch, A., additional, Spitz, M.R., additional, Stucker, I., additional, Yang, P., additional, and Taioli, E., additional
- Published
- 2006
- Full Text
- View/download PDF
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